Affinity DataIC50: 8nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 decatenation incubated for 30 mins in presence of ATP by ethidium bromide staining based analysisMore data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 12nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 Par E subunit by ATPase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase-IV assessed as reduction in decatenation using kinetoplast DNA as substrate incubated for 30 mins b...More data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
Vertex Pharmaceuticals
US Patent
Vertex Pharmaceuticals
US Patent
Affinity DataKi: 12nMAssay Description:The conversion of ATP to ADP by S. aureus TopoIV enzyme is coupled to the conversion of NADH to NAD+, and the progress of the reaction is measured by...More data for this Ligand-Target Pair
Affinity DataIC50: 15.5nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 subunit ParC2/ParE2 after 60 mins by malachite green staining assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase-IV assessed as reduction in decatenation using kinetoplast DNA as substrate incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 23.8nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 subunit ParC2/ParE2 after 60 mins by malachite green staining assayMore data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4More data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 Par E subunit by ATPase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase-IV assessed as reduction in decatenation using kinetoplast DNA as substrate incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 relaxation activity measured for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...More data for this Ligand-Target Pair
Affinity DataKi: 59nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4More data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 relaxation activity measured for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 85nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
TargetDNA topoisomerase 4 subunit B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of Staphylococcus aureus ParEMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 120nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 125nMAssay Description:Inhibition of wild type Staphylococcus aureus ATCC 29213 topoisomerase-4 subunit 2GrlA/2GrlB assessed as pBR322 relaxation after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
TargetDNA topoisomerase 4 subunit B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 Par E subunit by ATPase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 160nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 170nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 177nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 relaxation activity measured for 30 minsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 4 subunit B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 183nMAssay Description:Inhibition of Staphylococcus aureus DNA parE ATPase activity incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase-4 assessed as reduction in decatenation of kinetoplast DNA agarose gel electrophoresis methodMore data for this Ligand-Target Pair
Affinity DataIC50: 206nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase-IV assessed as reduction in decatenation using kinetoplast DNA as substrate incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataIC50: 215nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...More data for this Ligand-Target Pair
Affinity DataIC50: 241nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using supercoiled pNO1 plasmid DNA as substrate incubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 261nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 relaxation activity measured for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 280nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 290nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 using supercoiled pNO1 plasmid DNA as substrate incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase-4 assessed as reduction in decatenation of kinetoplast DNA agarose gel electrophoresis methodMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of Staphylococcus aureus RN4220 DNA topoisomerase 4 expressed in Escherichia coli BL21(DE3) cells using supercoiled pBR322 DNA as substrat...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 310nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...More data for this Ligand-Target Pair
Affinity DataIC50: 341nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 relaxation activity measured for 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of EphB4 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 370nMAssay Description:Inhibition of VEGFR2 autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 380nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase IV decatenation activity using kDNA as substrate by ethidium bromide/bromophenol blue staining base...More data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibition of Staphylococcus aureus topoisomerase 4 assessed as reduction in decatenation using kDNA as substrate incubated for 30 mins by fluorimetr...More data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Inhibition of Staphylococcus aureus DNA topoisomerase 4 decatenation activity using kDNA as substrate incubated for 10 to 20 min by ethidium bromide/...More data for this Ligand-Target Pair













































