Affinity DataIC50: 0.0100nMAssay Description:Inhibit ion of MAPK phosphorylation in LoVo cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.130nMAssay Description:Inhibition of ERK1 phosphorylation in VEGF-stimulated serum-starved human HUVEC cells by immunoblotting analysisMore data for this Ligand-Target Pair
Affinity DataKi: <0.300nMAssay Description:Binding affinity to ERK1 (unknown origin) measured after 20 mins in presence of [gamma33P]ATP by scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 0.550nMAssay Description:Inhibition of ERK1 phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 0.650nMAssay Description:Binding affinity to ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.760nMAssay Description:Inhibition of ERK1/2 phosphorylation in human PANC-1 cells incubated for 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:1. Purpose of the Assay:The ability of compounds to inhibit ERK1 and ERK2 kinase activity was measured.2. Assay Buffer:20 mM Hepes (pH 7.5), 10 mM Mg...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 1.40nMAssay Description:1. Purpose of the Assay:The ability of the compound to inhibit ERK1 and ERK2 kinase activity was measured.2. Assay Buffer:20 mM Hepes (pH 7.5), 10 mM...More data for this Ligand-Target Pair
Ligand InfoSimilars
Affinity DataIC50: 1.5nMAssay Description:Inhibition of ERK1 (unknown origin) using lipid as substrate after 40 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of ERK1/2 phosphorylation in human PANC-1 cells incubated for 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ERK1/2 phosphorylation in human PANC-1 cells incubated for 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of ERK1/2 phosphorylation in human A375 cells harboring BRAF V600E mutant after 4 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inhibition of ERK1 (unknown origin) measured after 2 hr by ADP-glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of ERK1 (unknown origin) using lipid as substrate after 40 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.5nMAssay Description:Inhibition of ERK1/2 in human A375 cells harboring BRAF V600E mutant assessed as suppression of RSK phosphorylation after 4 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of ERK1 (unknown origin) using lipid as substrate after 40 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of ERK1 (unknown origin) after 45 mins by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of ERK1 (unknown origin) incubated for 45 mins in presence of ATP by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Inhibition of ERK1 (unknown origin) using lipid as substrate after 40 mins by ADP-Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of ERK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK1/2 phosphorylation in human PANC-1 cells incubated for 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human KYSE520 cells incubated for 1 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphorylation after 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human KYSE520 cells incubated for 1 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.23nMAssay Description:The inhibiting activities of each of Compound-1 to Compound-24 against BTK wt, BTK(C481S), BMX, FAK, ITK, and EGFR wt kinases were determined using 3...More data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of ERK1/2 phosphorylation in human PANC-1 cells incubated for 3 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of ERK1 (unknown origin) using peptide substrate measured after 45 mins by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human KYSE520 cells incubated for 1 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK1 (unknown origin) using peptide substrate measured after 45 mins by IMAP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of ERK1/2 phosphorylation at Thr202/Tyr204 residues in human KYSE520 cells incubated for 1 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair







3D Structure (crystal)



























