Compile Data Set for Download or QSAR
Report error Found 39 Enz. Inhib. hit(s) with all data for entry = 50023710
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534424BDBM534424(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534567BDBM534567(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667151BDBM50667151(CHEMBL6176716)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667152BDBM50667152(CHEMBL6177473)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534424BDBM534424(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667150BDBM50667150(CHEMBL6173421)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667148BDBM50667148(CHEMBL6163751)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534274BDBM534274(WO2022086828, Example 2)
Affinity DataIC50: 1nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667151BDBM50667151(CHEMBL6176716)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667148BDBM50667148(CHEMBL6163751)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534274BDBM534274(WO2022086828, Example 2)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534319BDBM534319(WO2018148626, Example 46 | WO2022086828, Example 4...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534319BDBM534319(WO2018148626, Example 46 | WO2022086828, Example 4...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667150BDBM50667150(CHEMBL6173421)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534367BDBM534367((R)-5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534367BDBM534367((R)-5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667152BDBM50667152(CHEMBL6177473)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667153BDBM50667153(CHEMBL6168556)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50667152BDBM50667152(CHEMBL6177473)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667153BDBM50667153(CHEMBL6168556)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50667151BDBM50667151(CHEMBL6176716)
Affinity DataIC50: 12nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 534274BDBM534274(WO2022086828, Example 2)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 534481BDBM534481((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50667153BDBM50667153(CHEMBL6168556)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 534567BDBM534567(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50667150BDBM50667150(CHEMBL6173421)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 534410BDBM534410(WO2018148626, Example 146 | (S)-5-(2-amino-[1,2,4]...)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 534424BDBM534424(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50667148BDBM50667148(CHEMBL6163751)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 534319BDBM534319(WO2018148626, Example 46 | WO2022086828, Example 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50667149BDBM50667149(CHEMBL6173259)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 534367BDBM534367((R)-5-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of His-tagged full-length recombinant human PIK3CD/PIK3R1 extracted from baculovirus expression system incubated for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534481BDBM534481((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 18nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534567BDBM534567(3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...)
Affinity DataIC50: 24nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 534481BDBM534481((S)-3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-...)
Affinity DataIC50: 70nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667149BDBM50667149(CHEMBL6173259)
Affinity DataIC50: 89nMAssay Description:Inhibition of RIPK1 in human HT29-L23 cells assessed as decrease in MLKL phosphorylation preincubated for 30 mins followed by TNF-alpha/SMAC mimetic/...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
PI Health Sciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667149BDBM50667149(CHEMBL6173259)
Affinity DataIC50: 102nMAssay Description:Inhibition of N-terminal His-GST-tagged human RIPK1 (1 to 324 residues) extracted from baculovirus Sf9 cells incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed