Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50023696
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 37nMAssay Description:Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666916BDBM50666916(Enpatoran | M5049 | ENPATORAN | M-5049)
Affinity DataIC50: 74nMAssay Description:Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed b...More data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666915BDBM50666915(CHEMBL6172807)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666916BDBM50666916(Enpatoran | M5049 | ENPATORAN | M-5049)
Affinity DataIC50: 285nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 402nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666915BDBM50666915(CHEMBL6172807)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666928BDBM50666928(CHEMBL6172139)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666927BDBM50666927(CHEMBL6176179)
Affinity DataIC50: 730nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666925BDBM50666925(CHEMBL6174326)
Affinity DataIC50: 780nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 855nMAssay Description:Antagonist activity at TLR8 in human THP1-Dual MD2-CD14-TLR4 cells assessed as inhibition of TL8-506 induced DMR signals preincubated with compound f...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666924BDBM50666924(CHEMBL6177456)
Affinity DataIC50: 990nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 1.07E+3nMAssay Description:Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666926BDBM50666926(CHEMBL6177438)
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666915BDBM50666915(CHEMBL6172807)
Affinity DataIC50: 1.15E+3nMAssay Description:Antagonist activity at TLR8 in human PBMC cells assessed as inhibition of TL8-506 induced TNF release preincubated with compound for 1 hrs followed b...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666922BDBM50666922(CHEMBL6177000)
Affinity DataIC50: 1.66E+3nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666923BDBM50666923(CHEMBL6175139)
Affinity DataIC50: 1.68E+3nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666921BDBM50666921(CHEMBL6174494)
Affinity DataIC50: 1.73E+3nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666917BDBM50666917(CHEMBL6165363)
Affinity DataIC50: 3.06E+3nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666918BDBM50666918(CHEMBL6174282)
Affinity DataIC50: 3.46E+3nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666912BDBM50666912(CHEMBL6176113)
Affinity DataIC50: 3.57E+3nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666914BDBM50666914(CHEMBL6177284)
Affinity DataIC50: 6.62E+3nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666920BDBM50666920(CHEMBL6173119)
Affinity DataIC50: 8.15E+3nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666919BDBM50666919(CHEMBL6169015)
Affinity DataIC50: 1.83E+4nMAssay Description:Antagonist activity at TLR8 in HEK-Blue hTLR8 cells assessed as inhibition of TL8-506 induced NF-kappaB activation preincubated with compound for 1 h...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 7(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666913BDBM50666913(CHEMBL6174759)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity at TLR7 in HEK-Blue hTLR7 cells assessed as inhibition of CL307 induced NF-kappaB activation preincubated with compound for 1 hrs...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 7(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666914BDBM50666914(CHEMBL6177284)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity at TLR7 in HEK-Blue hTLR7 cells assessed as inhibition of CL307 induced NF-kappaB activation preincubated with compound for 1 hrs...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetToll-like receptor 7(Human)
University of Bonn

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666915BDBM50666915(CHEMBL6172807)
Affinity DataIC50: 5.00E+4nMAssay Description:Antagonist activity at TLR7 in HEK-Blue hTLR7 cells assessed as inhibition of CL307 induced NF-kappaB activation preincubated with compound for 1 hrs...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed