Compile Data Set for Download or QSAR
Report error Found 38 Enz. Inhib. hit(s) with all data for entry = 50023685
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50139181BDBM50139181(2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HMG-CoA reductase activity in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 34168BDBM34168(cid_53232 | SMR000058779 | MLS000069585 | LOVASTAT...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of HMG-CoA reductase activity in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rat)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50011036BDBM50011036(2-Methyl-butyric acid 8-[2-(4-hydroxy-6-oxo-tetrah...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of HMG-CoA reductase activity in rat liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666752BDBM50666752(CHEMBL6177725)
Affinity DataEC50:  22nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666771BDBM50666771(CHEMBL6172967)
Affinity DataEC50:  27nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666769BDBM50666769(CHEMBL6172944)
Affinity DataEC50:  43nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666774BDBM50666774(CHEMBL6177581)
Affinity DataEC50:  45nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666762BDBM50666762(CHEMBL6166703)
Affinity DataEC50:  56nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666772BDBM50666772(CHEMBL6167082)
Affinity DataEC50:  59nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666761BDBM50666761(CHEMBL6173060)
Affinity DataEC50:  63nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666751BDBM50666751(CHEMBL6172920)
Affinity DataEC50:  65nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666768BDBM50666768(CHEMBL6164875)
Affinity DataEC50:  68nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666778BDBM50666778(CHEMBL6177210)
Affinity DataKd:  88nMAssay Description:Binding affinity to human ClpP extracted from Escherichia coli assessed as equilibrium dissociation constant by biolayer interferometry techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666776BDBM50666776(CHEMBL6170047)
Affinity DataEC50:  93nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13530BDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Bcr-Abl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666770BDBM50666770(CHEMBL6176209)
Affinity DataEC50:  113nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666760BDBM50666760(CHEMBL6176195)
Affinity DataEC50:  151nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50647997BDBM50647997(CHEMBL5287669)
Affinity DataEC50:  156nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175493BDBM50175493(N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of Bcr-Abl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666775BDBM50666775(CHEMBL6170822)
Affinity DataEC50:  266nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666763BDBM50666763(CHEMBL6176600)
Affinity DataEC50:  270nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666758BDBM50666758(CHEMBL6176529)
Affinity DataEC50:  272nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666753BDBM50666753(CHEMBL6167868)
Affinity DataEC50:  302nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666773BDBM50666773(CHEMBL6175290)
Affinity DataEC50:  349nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240407BDBM50240407(N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Bcr-Abl (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666759BDBM50666759(CHEMBL6175608)
Affinity DataEC50:  490nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666777BDBM50666777(CHEMBL6172503)
Affinity DataEC50:  707nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666754BDBM50666754(CHEMBL6172448)
Affinity DataEC50:  761nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666765BDBM50666765(CHEMBL6165783)
Affinity DataEC50:  846nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666764BDBM50666764(CHEMBL6177204)
Affinity DataEC50:  1.00E+3nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666757BDBM50666757(CHEMBL6177671)
Affinity DataEC50:  1.29E+3nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666766BDBM50666766(CHEMBL6173967)
Affinity DataEC50:  1.36E+3nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666767BDBM50666767(CHEMBL6173944)
Affinity DataEC50:  1.43E+3nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50644286BDBM50644286(CHEMBL5571963)
Affinity DataEC50:  2.42E+3nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666755BDBM50666755(CHEMBL6176890)
Affinity DataEC50:  3.38E+3nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetATP-dependent Clp protease proteolytic subunit, mitochondrial(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50666756BDBM50666756(CHEMBL6177260)
Affinity DataEC50:  3.96E+3nMAssay Description:Activation of human ClpP extracted from Escherichia coli using Ac-WLA-AMC as substrate assessed as fluorescence signal measured after 10 mins incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProtein kinase C (PKC)(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50175493BDBM50175493(N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of PKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetProtein kinase C (PKC)(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240407BDBM50240407(N-(4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of PKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed