Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50023054
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50625566BDBM50625566(CHEMBL5417784)
Affinity DataKi:  0.290nMAssay Description:Binding affinity to Plasmodium falciparum DHFR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658376BDBM50658376(CHEMBL6166537)
Affinity DataIC50: 50nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated tetra-acetylated H4 peptide SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRK-Biotin as substra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetATPase family AAA domain-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658375BDBM50658375(CHEMBL6163050)
Affinity DataIC50: 270nMAssay Description:Inhibition of recombinant ATAD2 bromodomain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50619528BDBM50619528(CHEMBL5400930)
Affinity DataIC50: 900nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658379BDBM50658379(CHEMBL6134318)
Affinity DataIC50: 910nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated tetra-acetylated H4 peptide SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRK-Biotin as substra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658377BDBM50658377(CHEMBL6145996)
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated tetra-acetylated H4 peptide SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRK-Biotin as substra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658378BDBM50658378(CHEMBL5014569)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) using biotinylated tetra-acetylated H4 peptide SGRG-K(Ac)-GG-K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRK-Biotin as substra...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetATPase family AAA domain-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 10847BDBM10847(Theophylline (1,3-dimethylxanthine) | 1,3-dimethyl...)
Affinity DataIC50: 3.20E+5nMAssay Description:Inhibition of recombinant ATAD2 bromodomain (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCoagulation factor XII(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658374BDBM50658374(CHEMBL6144927)
Affinity DataIC50: 3.90E+5nMAssay Description:Inhibition of human FXIIa (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048525BDBM50048525(CHEMBL2426254)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium Falciparum)
Astex Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50195794BDBM50195794(CHEMBL3913021)
Affinity DataKi: >5.00E+5nMAssay Description:Binding affinity to Plasmodium falciparum DHFR assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed