Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50022793
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582698BDBM50582698(CHEMBL4448176 | US12522603, Compound TDI-008087)
Affinity DataIC50: 10nMAssay Description:Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 645624BDBM645624(US20240018138, Compound 102)
Affinity DataIC50: 27nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747241BDBM747241((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 32nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654378BDBM50654378(CHEMBL6132702)
Affinity DataIC50: 36nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747208BDBM747208((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 37nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747241BDBM747241((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 60nMAssay Description:Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747206BDBM747206((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 69nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654377BDBM50654377(CHEMBL6120686)
Affinity DataIC50: 140nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747194BDBM747194((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 170nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654381BDBM50654381(CHEMBL6142274)
Affinity DataIC50: 200nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50250108BDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747191BDBM747191((5-aminopyrimidin-2-yl)(6,7-dichloro-1,3,4,5-tetra...)
Affinity DataIC50: 220nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654375BDBM50654375(CHEMBL6148024)
Affinity DataIC50: 220nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747162BDBM747162((6,7-dichloro-1,3,4,5-tetrahydropyrido[4,3-b]indol...)
Affinity DataIC50: 360nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654367BDBM50654367(CHEMBL6148742)
Affinity DataIC50: 390nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654379BDBM50654379(CHEMBL6134448)
Affinity DataIC50: 410nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 276474BDBM276474(US12522603, Compound TDI-005397)
Affinity DataIC50: 440nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 645624BDBM645624(US20240018138, Compound 102)
Affinity DataIC50: 450nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747173BDBM747173((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 510nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747165BDBM747165((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 510nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654366BDBM50654366(CHEMBL6151278)
Affinity DataIC50: 540nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747208BDBM747208((S)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 560nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654376BDBM50654376(CHEMBL6150772)
Affinity DataIC50: 560nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747206BDBM747206((6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-pyrid...)
Affinity DataIC50: 820nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747163BDBM747163((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654372BDBM50654372(CHEMBL6144260)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654381BDBM50654381(CHEMBL6142274)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654371BDBM50654371(CHEMBL6103263)
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747191BDBM747191((5-aminopyrimidin-2-yl)(6,7-dichloro-1,3,4,5-tetra...)
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50582658BDBM50582658(CHEMBL4567157)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of Jak2 (unknown origin) assessed as inhibition of STAT5 phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654364BDBM50654364(CHEMBL6142627)
Affinity DataIC50: 2.97E+3nMAssay Description:Inhibition of 5-LO (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654375BDBM50654375(CHEMBL6148024)
Affinity DataIC50: 4.02E+3nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654368BDBM50654368(CHEMBL6133154)
Affinity DataIC50: 4.52E+3nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654373BDBM50654373(CHEMBL6152898)
Affinity DataIC50: 4.83E+3nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654363BDBM50654363(CHEMBL6142885)
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at human orexin-2 receptor assessed as inhibition of orexin-A-induced intracellular calcium mobilization after 30 mins by cell-ba...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747194BDBM747194((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747162BDBM747162((6,7-dichloro-1,3,4,5-tetrahydropyrido[4,3-b]indol...)
Affinity DataIC50: 5.79E+3nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654362BDBM50654362(CHEMBL6092095)
Affinity DataIC50: 5.99E+3nMAssay Description:Antagonist activity at human orexin-1 receptor assessed as inhibition of orexin-A-induced intracellular calcium mobilization after 30 mins by cell-ba...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654380BDBM50654380(CHEMBL6134170)
Affinity DataIC50: 9.26E+3nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654365BDBM50654365(CHEMBL6108936)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 5-LO (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747207BDBM747207((R)-(6,7-dichloro-1-methyl-1,3,4,5-tetrahydro-2H-p...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654374BDBM50654374(CHEMBL6096573)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654369BDBM50654369(CHEMBL6103345)
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654378BDBM50654378(CHEMBL6132702)
Affinity DataIC50: 2.29E+4nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654370BDBM50654370(CHEMBL6144215)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of LRRK2 (unknown origin) phosphorylation by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654379BDBM50654379(CHEMBL6134448)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654377BDBM50654377(CHEMBL6120686)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654376BDBM50654376(CHEMBL6150772)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654372BDBM50654372(CHEMBL6144260)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed