Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50022788
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at CGRP receptor (unknown origin) by cell based cAMP assay in presence of human serumMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.40nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as reduction of IL6-induced STAT3 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Agonist activity at human alpha4beta2 nAChR assessed as stimulation of [86Rb+] efflux after 2 mins by cell-based liquid scintillation countingMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2.10nMAssay Description:Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2.30nMAssay Description:Antagonist activity at CGRP receptor (unknown origin) by cell based cAMP assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 2.60nMAssay Description:Negative allosteric modulation of mGlu5 receptor (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.40nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as reduction of IL6-induced STAT3 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.40nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as reduction of IL6-induced STAT3 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.5nMAssay Description:Agonist activity at PAR2 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.60nMAssay Description:Negative allosteric modulation of mGlu5 receptor (unknown origin) by cell based assayMore data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as reduction of IL6-induced STAT3 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at human alpha4beta2 nAChR assessed as inhibition of nicotine-induced [86Rb+] efflux preincubated for 10 mins before nicotine exp...More data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 4.70nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Antagonist activity at human alpha4beta2 nAChR assessed as inhibition of nicotine-induced [86Rb+] efflux preincubated for 10 mins before nicotine exp...More data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Antagonist activity at human alpha4beta2 nAChR assessed as inhibition of nicotine-induced [86Rb+] efflux preincubated for 10 mins before nicotine exp...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 6.30nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as reduction of IL6-induced STAT3 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 6.40nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as reduction of IL6-induced STAT3 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 6.80nMAssay Description:Antagonist activity at human alpha4beta2 nAChR assessed as inhibition of nicotine-induced [86Rb+] efflux preincubated for 10 mins before nicotine exp...More data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Agonist activity at human alpha4beta2 nAChR assessed as stimulation of [86Rb+] efflux after 2 mins by cell-based liquid scintillation countingMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 7.40nMAssay Description:Inhibition of JAK1 (unknown origin) assessed as reduction of IL6-induced STAT3 phosphorylation by cell based assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 7.40nMAssay Description:Agonist activity at human alpha4beta2 nAChR assessed as stimulation of [86Rb+] efflux after 2 mins by cell-based liquid scintillation countingMore data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Inhibition of JAK2 (unknown origin) assessed as reduction of EPO-induced STAT5 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Human)
Binzhou Medical University
Curated by ChEMBL
Binzhou Medical University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Agonist activity at human alpha4beta2 nAChR assessed as stimulation of [86Rb+] efflux after 2 mins by cell-based liquid scintillation countingMore data for this Ligand-Target Pair
Ligand Info
