Compile Data Set for Download or QSAR
Report error Found 35 Enz. Inhib. hit(s) with all data for entry = 50022764
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654026BDBM50654026(CHEMBL6102705)
Affinity DataIC50: 83nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654029BDBM50654029(CHEMBL6134507)
Affinity DataIC50: 93nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654047BDBM50654047(CHEMBL6149300)
Affinity DataIC50: 96nMAssay Description:Inhibition of SYK assessed as reduction in dust mite-induced histamine release by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654026BDBM50654026(CHEMBL6102705)
Affinity DataIC50: 110nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654045BDBM50654045(CHEMBL6134216)
Affinity DataIC50: 115nMAssay Description:Inhibition of SYK assessed as reduction in TNFalpha secretion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654040BDBM50654040(CHEMBL6120677)
Affinity DataIC50: 131nMAssay Description:Inhibition of human muscarinic M3 receptor by cell based functional assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654037BDBM50654037(CHEMBL6134276)
Affinity DataIC50: 143nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654044BDBM50654044(CHEMBL6101819)
Affinity DataIC50: 192nMAssay Description:Inhibition of SYK assessed as reduction in GM-CSF secretion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654026BDBM50654026(CHEMBL6102705)
Affinity DataKi:  200nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654026BDBM50654026(CHEMBL6102705)
Affinity DataIC50: 211nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654046BDBM50654046(CHEMBL6151354)
Affinity DataIC50: 216nMAssay Description:Inhibition of SYK assessed as reduction in LTC4 secretion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654036BDBM50654036(CHEMBL6152732)
Affinity DataIC50: 237nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654027BDBM50654027(CHEMBL6143814)
Affinity DataIC50: 247nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654029BDBM50654029(CHEMBL6134507)
Affinity DataIC50: 261nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654034BDBM50654034(CHEMBL6092064)
Affinity DataIC50: 276nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654039BDBM50654039(CHEMBL6102555)
Affinity DataIC50: 306nMAssay Description:Inhibition of human muscarinic M4 receptor by cell based functional assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654041BDBM50654041(CHEMBL6147136)
Affinity DataIC50: 310nMAssay Description:Inhibition of human muscarinic M2 receptor by cell based functional assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654042BDBM50654042(CHEMBL6144830)
Affinity DataIC50: 403nMAssay Description:Inhibition of human muscarinic M1 receptor by cell based functional assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654043BDBM50654043(CHEMBL6103446)
Affinity DataIC50: 405nMAssay Description:Inhibition of SYK assessed as reduction in IL8 secretion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654038BDBM50654038(CHEMBL6142628)
Affinity DataIC50: 415nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654028BDBM50654028(CHEMBL6102446)
Affinity DataIC50: 429nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654035BDBM50654035(CHEMBL6147956)
Affinity DataIC50: 442nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654029BDBM50654029(CHEMBL6134507)
Affinity DataIC50: 461nMAssay Description:Inhibition of ALK Tyr1604 phosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654032BDBM50654032(CHEMBL6147816)
Affinity DataIC50: 630nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654033BDBM50654033(CHEMBL6142703)
Affinity DataIC50: 794nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654029BDBM50654029(CHEMBL6134507)
Affinity DataKi:  800nMAssay Description:Inhibition of SYK assessed as IL4 production by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654023BDBM50654023(CHEMBL6144706)
Affinity DataIC50: 840nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654049BDBM50654049(CHEMBL6141896)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of SYK assessed as reduction in anti-IgE-mediated tryptase release by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654030BDBM50654030(CHEMBL6142140)
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594969BDBM50594969(CHEMBL4218391)
Affinity DataIC50: 2.15E+3nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654031BDBM50654031(CHEMBL6120570)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654024BDBM50654024(CHEMBL6133701)
Affinity DataIC50: 3.46E+3nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654048BDBM50654048(CHEMBL6141811)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of SYK assessed as reduction in anti-IgE-mediated tryptase release by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654025BDBM50654025(CHEMBL6102184)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
East China Normal University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594969BDBM50594969(CHEMBL4218391)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of human NPM-ALK phosphorylation using 4-MeUP substrate by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed