Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with all data for entry = 50022665
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50465080BDBM50465080(CHEMBL6101902)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of UVB-induced AP-1 activation (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50465079BDBM50465079(CHEMBL6103508)
Affinity DataIC50: 4nMAssay Description:Inhibition of UVB-induced AP-1 activation (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476146BDBM50476146(CHEMBL6102512)
Affinity DataIC50: 6.30nMAssay Description:Effective concentration to measure the adherence of LFA-1 expressing JY8 cells to immobilized ICAM-1 in cell-based adhesion assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615688BDBM50615688(CHEMBL5280568)
Affinity DataIC50: 13nMAssay Description:Agonist activity at RoRb (unknown origin) expressed in HEK293 cells assessed as transcriptional activity by GAL4 NR reporter cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568616BDBM568616(5-[4-(Morpholin-4-yl)-3-(trifluoromethyl)phenyl]-3...)
Affinity DataIC50: 23nMAssay Description:Agonist activity at TRbeta (unknown origin) expressed in human HuH7 cells after 24 hrs by Gal4 CTF cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568713BDBM568713(US11427553, Example 188 | (6S)-5-[4′-Hydroxy...)
Affinity DataIC50: 26nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568706BDBM568706((6S)-6-Methyl-5-[4-(6-methylpyridin-3-yl)-3-(trifl...)
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568728BDBM568728((6S)-5-{4-[1-(Difluoromethyl)-1H-pyrazol-4-yl]-3-(...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568580BDBM568580((6S)-5-(3-Fluoro-4-morpholinophenyl)-6-methyl-3,6-...)
Affinity DataIC50: 43nMAssay Description:Inhibition of TASK-1 (unknown origin) by parental cell based thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568814BDBM568814((6S)-6-Methyl-5-[4-(4-methylpiperazin-1-yl)-3-(tri...)
Affinity DataIC50: 55nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 651355BDBM651355(US11897867, Example 124 | 6-[3,5-dichloro-4-(morph...)
Affinity DataIC50: 59nMAssay Description:Antagonist activity against human CGRP receptor by cell based cAMP accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568723BDBM568723((6S)-6-Methyl-5-[4-(2-methylpyridin-4-yl)-3-(trifl...)
Affinity DataIC50: 66nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568705BDBM568705((6S)-6-Methyl-5-[4-(pyridin-4-yl)-3-(trifluorometh...)
Affinity DataIC50: 67nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568720BDBM568720((6S)-5-[3′-Fluoro-2-(trifluoromethyl)[1,1...)
Affinity DataIC50: 74nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568704BDBM568704((6S)-5-[4-(2-Aminopyridin-4-yl)-3-(trifluoromethyl...)
Affinity DataIC50: 76nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476148BDBM50476148(CHEMBL6078361)
Affinity DataIC50: 81nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568674BDBM568674((6S)-5-[4′-Fluoro-2-(trifluoromethyl)bipheny...)
Affinity DataIC50: 82nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568585BDBM568585(5-(2,4′-Difluorobiphenyl-4-yl)-3,6-dihydro-2...)
Affinity DataIC50: 84nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476147BDBM50476147(CHEMBL6078425)
Affinity DataIC50: 90nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568718BDBM568718((6S)-5-[2′-Fluoro-2-(trifluoromethyl)[1,1...)
Affinity DataIC50: 140nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568769BDBM568769(5-[4-(4,4-Difluoropiperidin-1-yl)-3-(trifluorometh...)
Affinity DataIC50: 143nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568564BDBM568564(5-[3-Fluoro-4-(morpholin-4-yl)phenyl]-3,6-dihydro-...)
Affinity DataIC50: 180nMAssay Description:Effective concentration to measure the adherence of LFA-1 expressing JY8 cells to immobilized ICAM-1 in cell-based adhesion assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 651257BDBM651257(US11897867, Example 25 | 6-[3-Fluoro-4-(morpholin-...)
Affinity DataIC50: 190nMAssay Description:Agonist activity at RoRc (unknown origin) expressed in HEK293 cells assessed as transcriptional activity by GAL4 NR reporter cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476145BDBM50476145(CHEMBL6083085)
Affinity DataIC50: 217nMAssay Description:Antagonist activity against human CGRP receptor in presence of 50% human serum by cell based cAMP accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568567BDBM568567(5-(4′-Fluoro-2-methylbiphenyl-4-yl)-3,6-dihy...)
Affinity DataIC50: 218nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568721BDBM568721((6S)-6-Methyl-5-[4-(4-methylpyridin-3-yl)-3-(trifl...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568625BDBM568625(5-[4′-Fluoro-2-(trifluoromethoxy)biphenyl-4-...)
Affinity DataIC50: 222nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568562BDBM568562(5-[4-(4,4-Difluoropiperidin-1-yl)-3-fluorophenyl]-...)
Affinity DataIC50: 275nMAssay Description:Agonist activity at TRalpha (unknown origin) expressed in human HuH7 cells after 24 hrs by Gal4 CTF cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 568563BDBM568563(5-[4′-Fluoro-2-(trifluoromethyl)biphenyl-4-y...)
Affinity DataIC50: 284nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476150BDBM50476150(CHEMBL6074447)
Affinity DataIC50: 607nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 651354BDBM651354(US11897867, Example 123 | 6-[4-(morpholin-4-yl)phe...)
Affinity DataIC50: 1.00E+3nMAssay Description:Agonist activity at RoRc (unknown origin) expressed in HEK293 cells assessed as transcriptional activity by GAL4 NR reporter cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476149BDBM50476149(CHEMBL6083107)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed