Compile Data Set for Download or QSAR
Report error Found 21 Enz. Inhib. hit(s) with all data for entry = 50023495
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664265BDBM50664265(CHEMBL6170939)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664264BDBM50664264(CHEMBL6161309)
Affinity DataIC50: 1nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664267BDBM50664267(CHEMBL6164638)
Affinity DataIC50: 3nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664268BDBM50664268(CHEMBL6142019)
Affinity DataIC50: 21nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664261BDBM50664261(CHEMBL6170518)
Affinity DataIC50: 32nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 631159BDBM631159(US11802133, Example 8 | US11802133, Example 11)
Affinity DataIC50: 32nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664266BDBM50664266(CHEMBL6159861)
Affinity DataIC50: 37nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 631159BDBM631159(US11802133, Example 8 | US11802133, Example 11)
Affinity DataKd:  45nMAssay Description:Binding affinity to human MAGL assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664263BDBM50664263(CHEMBL6172677)
Affinity DataIC50: 46nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664262BDBM50664262(CHEMBL6165412)
Affinity DataIC50: 51nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664259BDBM50664259(CHEMBL6168025)
Affinity DataIC50: 62nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 631159BDBM631159(US11802133, Example 8 | US11802133, Example 11)
Affinity DataKd:  64nMAssay Description:Binding affinity to rat MAGL assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 631159BDBM631159(US11802133, Example 8 | US11802133, Example 11)
Affinity DataIC50: 65nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMonoglyceride lipase(Rat)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 631159BDBM631159(US11802133, Example 8 | US11802133, Example 11)
Affinity DataIC50: 71nMAssay Description:Inhibition of rat MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664260BDBM50664260(CHEMBL6169130)
Affinity DataIC50: 75nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMonoglyceride lipase(Mouse)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 631159BDBM631159(US11802133, Example 8 | US11802133, Example 11)
Affinity DataIC50: 91nMAssay Description:Inhibition of mouse MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 631165BDBM631165(US11802133, Example 14 | US11802133, Example 17)
Affinity DataIC50: 370nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664271BDBM50664271(CHEMBL6165073)
Affinity DataIC50: 569nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664270BDBM50664270(CHEMBL6150577)
Affinity DataIC50: 965nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 631171BDBM631171(US11802133, Example 20)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMonoglyceride lipase(Human)
Roche Pharma Research and Early Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50664269BDBM50664269(CHEMBL6168162)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human MAGL using 4-nitrophenylacetate as substrate preincubated for 20 mins followed by substrate addition and measured after 5 mins by...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed