Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50022826
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50549954BDBM50549954(CHEMBL4791380 | US11505536, Example 11)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of human Nav1.5 at -50 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 674349BDBM674349(US20240166622, Example 11 | 7-(4-Ethyl-3-(hydroxym...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581479BDBM581479(US11505536, Example 27 | 2-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50549953BDBM50549953(CHEMBL4751399 | US11505536, Example 93)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581506BDBM581506(US11505536, Example 54 | 2-(2-Chloro-6-fluoropheny...)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581505BDBM581505(US11505536, Example 53 | 6-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581509BDBM581509(US11505536, Example 57 | (R*)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 530465BDBM530465(8-(4-Ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654765BDBM50654765(CHEMBL6133462)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581486BDBM581486(US11505536, Example 34 | 2-(4-Ethyl-3-(hydroxymeth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 581508BDBM581508(US11505536, Example 56 | (S*)-6-(4-Ethyl-3-(hydrox...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654763BDBM50654763(CHEMBL6149485)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 674347BDBM674347(US20240166622, Example 10 | 7-(4-Ethyl-3-(hydroxym...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654764BDBM50654764(CHEMBL6133297)
Affinity DataIC50: 15nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based IonWorks barracuda automated electrophysiology methodMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Janssen Research and Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 674350BDBM674350(US20240166622, Example 12 | 3-(2-Chloro-6-fluoroph...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Nav1.7 at -60 mV holding potential by cell-based manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed