Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50023463
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 0.0110nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 0.244nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 0.424nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300690BDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of FLT3 ITD mutant in human MV4-11 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300696BDBM50300696(N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(3-morphol...)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of FLT3 ITD mutant in human MV4-11 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300695BDBM50300695(N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-piperid...)
Affinity DataIC50: 0.880nMAssay Description:Inhibition of FLT3 ITD mutant in human MV4-11 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300690BDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300690BDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to FLT3 ITD mutant (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50357312BDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of wild type BTK (unknown origin) stably transfected in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50300690BDBM50300690(CHEMBL576982 | N-(5-tert-Butyl-isoxazol-3-yl)-N'-{...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663948BDBM50663948(CHEMBL6165320)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of wild type BTK (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311017BDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 11nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50307942BDBM50307942(CHEMBL598194 | US8796293, 69 | 4-Amino-N-(4-chloro...)
Affinity DataIC50: 13nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311017BDBM50311017(N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyri...)
Affinity DataIC50: 18nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50663948BDBM50663948(CHEMBL6165320)
Affinity DataIC50: 21nMAssay Description:Inhibition of wild type BTK (unknown origin) stably transfected in HEK293 cellsMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetNeuromedin-K receptor(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50112244BDBM50112244(CHEMBL3608680 | US9422299, 5 | US10030025, Compoun...)
Affinity DataKi:  22nMAssay Description:Binding affinity to human recombinant NK3R assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 209866BDBM209866(PF-06651600 | US9617258, Example 5 | US11111242, E...)
Affinity DataIC50: 33nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50307942BDBM50307942(CHEMBL598194 | US8796293, 69 | 4-Amino-N-(4-chloro...)
Affinity DataIC50: 57nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
University of South China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50307942BDBM50307942(CHEMBL598194 | US8796293, 69 | 4-Amino-N-(4-chloro...)
Affinity DataIC50: 66nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed