Compile Data Set for Download or QSAR
Report error Found 43 Enz. Inhib. hit(s) with all data for entry = 50006449
TargetBDNF/NT-3 growth factors receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0500nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.100nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50146167BDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 469269BDBM469269(US10807985, Compound 44 | US20250129067, Compound ...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human Nav1.4 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435010BDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1/2/3/4(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.3 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435010BDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435010BDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.2 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435010BDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human Nav1.2 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 374727BDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 0.830nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human Nav1.5 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 3(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human Nav1.3 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Nav1.5 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594747BDBM50594747(Pirtobrutinib | Loxo-305 | LOXO-305 | LY-3527727 |...)
Affinity DataIC50: 3.70nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436459BDBM50436459(CHEMBL2396661)
Affinity DataIC50: 4nMAssay Description:Inhibition of human Nav1.5 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50436459BDBM50436459(CHEMBL2396661)
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNT-3 growth factor receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human Nav1.5 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50458159BDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50: 6.20nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetALK tyrosine kinase receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human Nav1.4 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594747BDBM50594747(Pirtobrutinib | Loxo-305 | LOXO-305 | LY-3527727 |...)
Affinity DataIC50: 8.5nMAssay Description:Displacement of [3H]-diprenorphine from human kappa opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetEndothelial PAS domain-containing protein 1(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 373040BDBM373040(US9896418, Compound 289 | US10597366, Compound 289)
Affinity DataIC50: 9nMAssay Description:Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGTPase KRas(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50539763BDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMast/stem cell growth factor receptor Kit(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177716BDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Nav1.4 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.1 assessed as tonic block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594747BDBM50594747(Pirtobrutinib | Loxo-305 | LOXO-305 | LY-3527727 |...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 158154BDBM158154(US9029356, 11 | US9255087, 11 | US10081622, Compou...)
Affinity DataIC50: 12nMAssay Description:Inhibition of human Nav1.4 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50355497BDBM50355497(AZD-6244 | CHEMBL1614701)
Affinity DataIC50: 14nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50177716BDBM50177716(CHEMBL3813873 | US11679110, Compound Pexidartinib ...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Nav1.4 assessed as 10 Hz block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 184556BDBM184556(US9150579, B1)
Affinity DataIC50: 22nMAssay Description:Inhibition of human Nav1.1 assessed as 10 Hz block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 301310BDBM301310(3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170079BDBM50170079(CHEMBL3805002)
Affinity DataIC50: 30nMAssay Description:Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170078BDBM50170078(CHEMBL3806196)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.5 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170079BDBM50170079(CHEMBL3805002)
Affinity DataIC50: 200nMAssay Description:Inhibition of human Nav1.6 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 244nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 118299BDBM118299(US8653092, 67)
Affinity DataIC50: 424nMAssay Description:Displacement of [3H]-diprenorphine from human delta opioid receptor after 120 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50170078BDBM50170078(CHEMBL3806196)
Affinity DataIC50: 900nMAssay Description:Inhibition of human Nav1.6 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 184556BDBM184556(US9150579, B1)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human Nav1.2 assessed as tonic block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Shengjing Hospital of China Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514402BDBM50514402(CHEMBL4535757 | US11345701, Compound Amg-510)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human Nav1.1 assessed as inactivated-state block using double pulse protocol by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details Article
PubMed