Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50023359
LigandChemical structure of BindingDB Monomer ID 50652796BDBM50652796(Sonolisib | Px-866 | PX-866)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of PI3K-p110alpha (unknown origin) extracted from baculovirus-infected Sf9 cells incubated for 1 hr by microbeta counter analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 36609BDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR (unknown origin) in expressed in HEK293 cells incubated for 15 mins by Immuno-blotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50434806BDBM50434806(CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of PI3K-p110alpha (unknown origin) extracted from baculovirus-infected Sf9 cells incubated for 1 hr by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50348452BDBM50348452(CHEMBL1801204 | US9102670, 1a | AZD-8055)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant mTOR (unknown origin) transfected in HEK293 cells by immunoblotting assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50434806BDBM50434806(CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of PI3K p120gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50434806BDBM50434806(CHEMBL2387080 | Taselisib | GDC 0032 | 2-(4-(2-(1-...)
Affinity DataIC50: 0.970nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 86633BDBM86633(JNK-IN-8)
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50652796BDBM50652796(Sonolisib | Px-866 | PX-866)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3K p120gamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50094464BDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 315477BDBM315477(US10172858, Table 1.22 | US10172858, Table 1.1)
Affinity DataIC50: 1nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50121212BDBM50121212(CHEMBL3622372)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant VPS34 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50121212BDBM50121212(CHEMBL3622372)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to human recombinant VPS34 assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429701BDBM50429701(AZD-2014 | CHEMBL2336325 | US9102670, 1ap)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50652796BDBM50652796(Sonolisib | Px-866 | PX-866)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50094464BDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: 4nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 86633BDBM86633(JNK-IN-8)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50088378BDBM50088378(CHEBI:68478 | Afinitor | Afinitor Disperz | Everol...)
Affinity DataIC50: 5nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662426BDBM50662426(Inlexisertib | DCC-3116 FREE BASE | DCC3116 FREE B...)
Affinity DataIC50: 6nMAssay Description:Inhibition of ULK1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50503134BDBM50503134(CHEMBL4447963)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant PI3Kdelta by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662426BDBM50662426(Inlexisertib | DCC-3116 FREE BASE | DCC3116 FREE B...)
Affinity DataIC50: 9nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50310989BDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50541534BDBM50541534((+)-Magnolin | CHEMBL519926)
Affinity DataIC50: 17nMAssay Description:Inhibition of ERK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 86633BDBM86633(JNK-IN-8)
Affinity DataIC50: 19nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50271371BDBM50271371(CHEMBL4125718)
Affinity DataEC50:  19nMAssay Description:Agonist activity at ULK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50503134BDBM50503134(CHEMBL4447963)
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant VPS34 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25045BDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25045BDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataKi:  20nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 13(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 20nMAssay Description:Inhibition of P38delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50662427BDBM50662427(CHEMBL6152129)
Affinity DataEC50:  24nMAssay Description:Agonist activity at ULK1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111572BDBM50111572(CHEMBL3605057)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant N-terminal 6His-tagged ULK2 kinase domain ( 1 to 276 residues) (unknown origin) extracted from Escherichia coli BL21 (DE3) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 38nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16018BDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 9(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16018BDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of JNK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50111572BDBM50111572(CHEMBL3605057)
Affinity DataIC50: 45nMAssay Description:Inhibition of N-terminal 6His-tagged recombinant ULK1 kinase domain (1 to 283 residues) (unknown origin) extracted from Escherichia coli BL21 (DE3) m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 11(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 65nMAssay Description:Inhibition of p38beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50307942BDBM50307942(CHEMBL598194 | US8796293, 69 | 4-Amino-N-(4-chloro...)
Affinity DataIC50: 66nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25045BDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataIC50: 83nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50541534BDBM50541534((+)-Magnolin | CHEMBL519926)
Affinity DataIC50: 87nMAssay Description:Inhibition of ERK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 16018BDBM16018(cid_8515 | SP 600125 | ChemBiol10705 Compound 4 | ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 379177BDBM379177(US10266549, Example 88 | US10266549, Example 171a ...)
Affinity DataIC50: 108nMAssay Description:Inhibition of ULK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 25045BDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of PI3K p120gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50207165BDBM50207165(4-morpholin-4-yl-2-phenyl-pyrido[3',2':4,5]furo[3,...)
Affinity DataIC50: 160nMAssay Description:Inhibition of PI3K-p110alpha (unknown origin) extracted from baculovirus-infected Sf9 cells incubated for 1 hr by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCysteine protease ATG4B(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 34233BDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataIC50: 189nMAssay Description:Inhibition of 6His-tagged recombinant ATG4B (unknown origin) extracted from Escherichia coli BL21 (DE3) measured for 1 hr by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMicrotubule-associated proteins 1A/1B light chain 3B(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50640061BDBM50640061(CHEMBL5563109)
Affinity DataIC50: 200nMAssay Description:Inhibition of LBP2 interaction to LC3B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 53290BDBM53290(2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynapht...)
Affinity DataIC50: 310nMAssay Description:Inhibition of MCL-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase 12(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 13533BDBM13533(1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-m...)
Affinity DataIC50: 520nMAssay Description:Inhibition of p38gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50207178BDBM50207178(4-morpholin-4-yl-pyrido[3',2':4,5]furo[3,2-d]pyrim...)
Affinity DataIC50: 560nMAssay Description:Inhibition of PI3K-p110alpha (unknown origin) extracted from baculovirus-infected Sf9 cells incubated for 1 hr by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 379177BDBM379177(US10266549, Example 88 | US10266549, Example 171a ...)
Affinity DataIC50: 711nMAssay Description:Inhibition of ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50069761BDBM50069761(CHEMBL2391504)
Affinity DataIC50: 740nMAssay Description:Inhibition of VPS34 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50398379BDBM50398379(CHEMBL2177390 | US10550114, Compound GDC-0068 | US...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PI3K-p110alpha (unknown origin) extracted from baculovirus-infected Sf9 cells incubated for 1 hr by microbeta counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
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