Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50021561
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717900BDBM717900(US20250042857, Example A-6)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50581659BDBM50581659(CHEMBL4519023 | US20230339952, Comparative Compoun...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717931BDBM717931(US20250042857, Example B-38)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717922BDBM717922(US20250042857, Example B-23)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717899BDBM717899(US20250042857, Example A-5)
Affinity DataIC50: 6nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717897BDBM717897(US20250042857, Example A-3)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717932BDBM717932(US20250042857, Example B-41)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717920BDBM717920(US20250042857, Example B-21)
Affinity DataIC50: 7nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717923BDBM717923(US20250042857, Example B-24)
Affinity DataIC50: 8.5nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641969BDBM50641969(CHEMBL5592526)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641968BDBM50641968(CHEMBL5583880)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717918BDBM717918(US20250042857, Example B-4)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641964BDBM50641964(CHEMBL5584077)
Affinity DataIC50: 10nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717906BDBM717906(US20250042857, Example A-40)
Affinity DataIC50: 11nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717895BDBM717895(US20250042857, Example A-1)
Affinity DataIC50: 11nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717930BDBM717930(US20250042857, Example B-37)
Affinity DataIC50: 12nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641971BDBM50641971(CHEMBL5575769)
Affinity DataIC50: 13nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717903BDBM717903(US20250042857, Example A-17)
Affinity DataIC50: 13nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641965BDBM50641965(CHEMBL5570758)
Affinity DataIC50: 13nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641967BDBM50641967(CHEMBL5570028)
Affinity DataIC50: 14nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641970BDBM50641970(CHEMBL5571673)
Affinity DataIC50: 15nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641963BDBM50641963(CHEMBL5595806)
Affinity DataIC50: 15nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50614629BDBM50614629(BAY-293)
Affinity DataIC50: 21nMAssay Description:Inhibition of SOS1/KRAS G12D mutant (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 717996BDBM717996(US20250042857, Example B-110)
Affinity DataIC50: 22nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetKRas/Son of Sevenless Homolog 1(Human)
Haihe Biopharma

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641966BDBM50641966(CHEMBL5594101)
Affinity DataIC50: 23nMAssay Description:Inhibition of SOS1/KRAS G12C mutant (unknown origin) protein-protein interaction incubated for 2 hrs by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed