BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50340009 CC(=O)N1CCN(CC1)c1ccc(OC[C@H]2CO[C@@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 XMAYWYJOQHXEEK-OZXSUGGESA-N 8610 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one::24F2-1,25(OH)D3::CHEMBL75::KTZ::Ketoconazole::Ketoconazole (k)::US9138393, Ketoconozole::US9144538, Ketoconozole Cytochrome P450 4F2 740 ChEMBL 10.1124/dmd.110.035378 10.7270/Q28917MJ 21045201 Jin, Y; Zollinger, M; Borell, H; Zimmerlin, A; Patten, CJ Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8610&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search KKK 456201 11109351 48339 CHEMBL75 2568 ZINC00643138 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 50340021 CC(=O)N1CCN(CC1)c1ccc(OC[C@H]2CO[C@@](Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1 InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1 XMAYWYJOQHXEEK-OZXSUGGESA-N 8610 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one::24F2-1,25(OH)D3::CHEMBL75::KTZ::Ketoconazole::Ketoconazole (k)::US9138393, Ketoconozole::US9144538, Ketoconozole Cytochrome P450 4F2 1600 ChEMBL 10.1124/dmd.110.035378 10.7270/Q28917MJ 21045201 Jin, Y; Zollinger, M; Borell, H; Zimmerlin, A; Patten, CJ Novartis Institutes for BioMedical Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8610&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search KKK 456201 11109351 48339 CHEMBL75 2568 ZINC00643138 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51295219 OC(=O)CCCCCNn1nnc2ccccc12 InChI=1S/C12H16N4O2/c17-12(18)8-2-1-5-9-13-16-11-7-4-3-6-10(11)14-15-16/h3-4,6-7,13H,1-2,5,8-9H2,(H,17,18) ORPGHKGCVVGSIW-UHFFFAOYSA-N 50527962 CHEMBL4442292 Cytochrome P450 4F2 1130000 ChEMBL 10.1021/acs.jmedchem.0c00101 10.7270/Q2HT2SS4 32302132 Kowalski, JP; McDonald, MG; Pelletier, RD; Hanenberg, H; Wiek, C; Rettie, AE University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527962&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155515709 440736544 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51295223 OC(=O)CCCCCNn1nnc2ccccc12 InChI=1S/C12H16N4O2/c17-12(18)8-2-1-5-9-13-16-11-7-4-3-6-10(11)14-15-16/h3-4,6-7,13H,1-2,5,8-9H2,(H,17,18) ORPGHKGCVVGSIW-UHFFFAOYSA-N 50527962 CHEMBL4442292 Cytochrome P450 4F2 647000 ChEMBL 10.1021/acs.jmedchem.0c00101 10.7270/Q2HT2SS4 32302132 Kowalski, JP; McDonald, MG; Pelletier, RD; Hanenberg, H; Wiek, C; Rettie, AE University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527962&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155515709 440736544 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51295224 OC(=O)CCCCCCCNn1nnc2ccccc12 InChI=1S/C14H20N4O2/c19-14(20)10-4-2-1-3-7-11-15-18-13-9-6-5-8-12(13)16-17-18/h5-6,8-9,15H,1-4,7,10-11H2,(H,19,20) XRQULSHHDALTQA-UHFFFAOYSA-N 50527963 CHEMBL4557940 Cytochrome P450 4F2 221000 ChEMBL 10.1021/acs.jmedchem.0c00101 10.7270/Q2HT2SS4 32302132 Kowalski, JP; McDonald, MG; Pelletier, RD; Hanenberg, H; Wiek, C; Rettie, AE University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527963&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 154727580 440736545 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51295243 OC(=O)CCCCCCCNn1nnc2ccccc12 InChI=1S/C14H20N4O2/c19-14(20)10-4-2-1-3-7-11-15-18-13-9-6-5-8-12(13)16-17-18/h5-6,8-9,15H,1-4,7,10-11H2,(H,19,20) XRQULSHHDALTQA-UHFFFAOYSA-N 50527963 CHEMBL4557940 Cytochrome P450 4F2 212000 ChEMBL 10.1021/acs.jmedchem.0c00101 10.7270/Q2HT2SS4 32302132 Kowalski, JP; McDonald, MG; Pelletier, RD; Hanenberg, H; Wiek, C; Rettie, AE University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527963&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 154727580 440736545 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178679 CC(C)(CCN1CCc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2C1=O)C(O)=O InChI=1S/C24H26N4O4/c1-24(2,23(30)31)9-12-28-11-8-17-4-3-16(13-19(17)22(28)29)15-32-18-5-6-20(25-14-18)21-7-10-26-27-21/h3-7,10,13-14H,8-9,11-12,15H2,1-2H3,(H,26,27)(H,30,31) URJKZZHKJBIIIU-UHFFFAOYSA-N 558195 US11365192, Example 8-6 Cytochrome P450 4F2 53.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558195&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112514 471698854 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178681 OC(=O)CCc1ccc(CCCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C20H21N3O3/c24-20(25)10-7-16-5-3-15(4-6-16)2-1-13-26-17-8-9-18(21-14-17)19-11-12-22-23-19/h3-6,8-9,11-12,14H,1-2,7,10,13H2,(H,22,23)(H,24,25) LSXPBXVTYFZTOT-UHFFFAOYSA-N 558196 US11365192, Example 8-7 Cytochrome P450 4F2 280 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558196&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112515 471698855 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178683 OC(=O)Cc1ccc(CCCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C19H19N3O3/c23-19(24)12-15-5-3-14(4-6-15)2-1-11-25-16-7-8-17(20-13-16)18-9-10-21-22-18/h3-10,13H,1-2,11-12H2,(H,21,22)(H,23,24) JBSZYQIPJFVCCM-UHFFFAOYSA-N 558197 US11365192, Example 8-8 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558197&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112516 471698856 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178685 OC(=O)COc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C17H15N3O4/c21-17(22)11-24-13-3-1-12(2-4-13)10-23-14-5-6-15(18-9-14)16-7-8-19-20-16/h1-9H,10-11H2,(H,19,20)(H,21,22) QIYMOXQWUYMOBT-UHFFFAOYSA-N 558198 US11365192, Example 8-9 Cytochrome P450 4F2 6200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558198&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112517 471698857 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178687 OC(=O)c1ccnc(c1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H16N4O3/c26-21(27)16-6-8-22-20(11-16)15-3-1-2-14(10-15)13-28-17-4-5-18(23-12-17)19-7-9-24-25-19/h1-12H,13H2,(H,24,25)(H,26,27) YQBQXCZFTWZXQF-UHFFFAOYSA-N 558199 US11365192, Example 8-10 Cytochrome P450 4F2 1300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558199&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112518 471698858 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178689 OC(=O)c1cc(ccn1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H16N4O3/c26-21(27)20-11-16(6-8-22-20)15-3-1-2-14(10-15)13-28-17-4-5-18(23-12-17)19-7-9-24-25-19/h1-12H,13H2,(H,24,25)(H,26,27) CTYUBVWFESEOQB-UHFFFAOYSA-N 558200 US11365192, Example 8-11 Cytochrome P450 4F2 120 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558200&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112519 471698859 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178691 OC(=O)Cn1cc(CCCCOc2ccc(nc2)-c2ccn[nH]2)cn1 InChI=1S/C17H19N5O3/c23-17(24)12-22-11-13(9-20-22)3-1-2-8-25-14-4-5-15(18-10-14)16-6-7-19-21-16/h4-7,9-11H,1-3,8,12H2,(H,19,21)(H,23,24) DDPRNNKVMKTJHR-UHFFFAOYSA-N 558201 US11365192, Example 8-12 Cytochrome P450 4F2 5000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558201&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323928 471698860 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178693 CC(C)(C(O)=O)n1cc(CCCCOc2ccc(nc2)-c2ccn[nH]2)cn1 InChI=1S/C19H23N5O3/c1-19(2,18(25)26)24-13-14(11-22-24)5-3-4-10-27-15-6-7-16(20-12-15)17-8-9-21-23-17/h6-9,11-13H,3-5,10H2,1-2H3,(H,21,23)(H,25,26) ICTYPIHMKXAJFK-UHFFFAOYSA-N 558202 US11365192, Example 8-13 Cytochrome P450 4F2 8300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558202&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323836 471698861 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178695 CC(C)(C(O)=O)n1ccc(CCCCOc2ccc(nc2)-c2ccn[nH]2)n1 InChI=1S/C19H23N5O3/c1-19(2,18(25)26)24-11-9-14(23-24)5-3-4-12-27-15-6-7-16(20-13-15)17-8-10-21-22-17/h6-11,13H,3-5,12H2,1-2H3,(H,21,22)(H,25,26) XWWLIVPCWOQWIV-UHFFFAOYSA-N 558203 US11365192, Example 8-14 Cytochrome P450 4F2 11000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558203&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323931 471698862 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178697 OC(=O)Cn1ccc(CCCCOc2ccc(nc2)-c2ccn[nH]2)cc1=O InChI=1S/C19H20N4O4/c24-18-11-14(7-9-23(18)13-19(25)26)3-1-2-10-27-15-4-5-16(20-12-15)17-6-8-21-22-17/h4-9,11-12H,1-3,10,13H2,(H,21,22)(H,25,26) IRECZYBEUGWKAD-UHFFFAOYSA-N 558204 US11365192, Example 8-15 Cytochrome P450 4F2 1400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558204&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112520 471698863 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178699 OC(=O)Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)n1 InChI=1S/C16H14N4O3/c21-16(22)8-11-2-1-3-12(19-11)10-23-13-4-5-14(17-9-13)15-6-7-18-20-15/h1-7,9H,8,10H2,(H,18,20)(H,21,22) LPCRGYHCRVLTSU-UHFFFAOYSA-N 558205 US11365192, Example 8-16 Cytochrome P450 4F2 680 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558205&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112521 471698864 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178701 OC(=O)C12CC(COc3ccc(nc3)-c3ccn[nH]3)(C1)C2 InChI=1S/C15H15N3O3/c19-13(20)15-6-14(7-15,8-15)9-21-10-1-2-11(16-5-10)12-3-4-17-18-12/h1-5H,6-9H2,(H,17,18)(H,19,20) UQRMYYLYOYWOGA-UHFFFAOYSA-N 558206 US11365192, Example 8-17 Cytochrome P450 4F2 22000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558206&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323941 471698865 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178703 OC(=O)C12CCC(COc3ccc(nc3)-c3ccn[nH]3)(CC1)CC2 InChI=1S/C18H21N3O3/c22-16(23)18-7-4-17(5-8-18,6-9-18)12-24-13-1-2-14(19-11-13)15-3-10-20-21-15/h1-3,10-11H,4-9,12H2,(H,20,21)(H,22,23) SXZOCKMPTCVENH-UHFFFAOYSA-N 558207 US11365192, Example 8-18 Cytochrome P450 4F2 16000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558207&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323987 471698866 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178705 OC(=O)C1CCCC(COc2ccc(nc2)-c2ccn[nH]2)C1 558149 US11365192, Example 1-54::US11365192, Example 9-1 Cytochrome P450 4F2 1900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558149&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658384 471698808 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178707 C[Si](C)(C)OC1(CNC1)c1cccc(COc2ccc(nc2)-c2ccnn2C2CCCCO2)c1 InChI=1S/C26H34N4O3Si/c1-34(2,3)33-26(18-27-19-26)21-8-6-7-20(15-21)17-32-22-10-11-23(28-16-22)24-12-13-29-30(24)25-9-4-5-14-31-25/h6-8,10-13,15-16,25,27H,4-5,9,14,17-19H2,1-3H3 UJWXXFDGMKDIFL-UHFFFAOYSA-N 558209 US11365192, Example 9-2 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558209&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 161112627 471698867 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178709 CC(C)(OCCCOCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C19H27N3O5/c1-19(2,18(23)24)27-13-5-11-25-10-3-4-12-26-15-6-7-16(20-14-15)17-8-9-21-22-17/h6-9,14H,3-5,10-13H2,1-2H3,(H,21,22)(H,23,24) OHGYUUIRCADLNJ-UHFFFAOYSA-N 558210 US11365192, Example 9-3 Cytochrome P450 4F2 490 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558210&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323950 471698868 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178711 OC(=O)Cn1cc(cn1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H17N5O3/c26-20(27)12-25-11-16(9-23-25)15-3-1-2-14(8-15)13-28-17-4-5-18(21-10-17)19-6-7-22-24-19/h1-11H,12-13H2,(H,22,24)(H,26,27) NAWVSFJBYMEPSG-UHFFFAOYSA-N 558211 2-[4-[3-[[6-(1H-Pyrazol-5-yl)-6-pyridinyl]oxymethyl]phenyl]-1-pyrazolyl]acetic Acid::US11365192, Example 9-4 Cytochrome P450 4F2 740 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558211&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148592362 471698869 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178713 OC(=O)CCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C13H15N3O3/c17-13(18)3-1-2-8-19-10-4-5-11(14-9-10)12-6-7-15-16-12/h4-7,9H,1-3,8H2,(H,15,16)(H,17,18) MZJLUDLXJNEHIX-UHFFFAOYSA-N 558212 5-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]pentanoic Acid::US11365192, Example 10-1 Cytochrome P450 4F2 19000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558212&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487673 471698870 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178715 OC(=O)c1cccc(COc2ccc(nc2)-c2ccnn2C2CCCCO2)n1 InChI=1S/C20H20N4O4/c25-20(26)17-5-3-4-14(23-17)13-28-15-7-8-16(21-12-15)18-9-10-22-24(18)19-6-1-2-11-27-19/h3-5,7-10,12,19H,1-2,6,11,13H2,(H,25,26) SCQAQJGMFMOKLW-UHFFFAOYSA-N 558213 2-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenoxy]acetic Acid::US11365192, Example 10-2 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558213&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323891 471698871 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178717 Oc1cc(CCCOc2ccc(nc2)-c2ccn[nH]2)cc(F)c1F InChI=1S/C17H15F2N3O2/c18-13-8-11(9-16(23)17(13)19)2-1-7-24-12-3-4-14(20-10-12)15-5-6-21-22-15/h3-6,8-10,23H,1-2,7H2,(H,21,22) QMIXPZDNIXXOJE-UHFFFAOYSA-N 558214 2,3-Difluoro-5-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]propyl]phenol::US11365192, Example 11-1 Cytochrome P450 4F2 5.10 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558214&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526519 471698872 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178719 Oc1cccc(CCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H17N3O2/c21-14-5-1-3-13(11-14)4-2-10-22-15-6-7-16(18-12-15)17-8-9-19-20-17/h1,3,5-9,11-12,21H,2,4,10H2,(H,19,20) SSPKVRLWKRTNLQ-UHFFFAOYSA-N 558215 US11365192, Example 11-2 Cytochrome P450 4F2 19.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558215&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112522 471698873 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178721 CCOC(=O)c1cc(CBr)ccc1Cl InChI=1S/C10H10BrClO2/c1-2-14-10(13)8-5-7(6-11)3-4-9(8)12/h3-5H,2,6H2,1H3 SIFSZUJFCRVVNG-UHFFFAOYSA-N 558216 US11365192, Example 11-3 Cytochrome P450 4F2 7.30 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558216&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 130141165 471698874 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178723 NS(=O)(=O)CCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C13H18N4O3S/c14-21(18,19)9-3-1-2-8-20-11-4-5-12(15-10-11)13-6-7-16-17-13/h4-7,10H,1-3,8-9H2,(H,16,17)(H2,14,18,19) XXDKUQMRASUVIL-UHFFFAOYSA-N 558217 5-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]-1-pentanesulfonamide::US11365192, Example 11-4 Cytochrome P450 4F2 1300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558217&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526915 471698875 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178725 Cc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1O InChI=1S/C16H15N3O2/c1-11-2-3-12(8-16(11)20)10-21-13-4-5-14(17-9-13)15-6-7-18-19-15/h2-9,20H,10H2,1H3,(H,18,19) SJGBSSCKRJOPOE-UHFFFAOYSA-N 558218 2-Methyl-5-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenol::US11365192, Example 12-1 Cytochrome P450 4F2 6.20 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558218&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526730 471698876 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178727 Oc1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1F InChI=1S/C15H12FN3O2/c16-12-3-1-10(7-15(12)20)9-21-11-2-4-13(17-8-11)14-5-6-18-19-14/h1-8,20H,9H2,(H,18,19) RDOMNPDEPSGXSS-UHFFFAOYSA-N 558219 US11365192, Example 12-2 Cytochrome P450 4F2 11.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558219&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112523 471698877 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178729 Oc1cc(F)cc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C15H12FN3O2/c16-11-5-10(6-12(20)7-11)9-21-13-1-2-14(17-8-13)15-3-4-18-19-15/h1-8,20H,9H2,(H,18,19) INHOKGOCKVQKOG-UHFFFAOYSA-N 558220 US11365192, Example 12-3 Cytochrome P450 4F2 25.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558220&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112524 471698878 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178731 Oc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C15H13N3O2/c19-12-3-1-2-11(8-12)10-20-13-4-5-14(16-9-13)15-6-7-17-18-15/h1-9,19H,10H2,(H,17,18) XDCFMZBFUQMRAG-UHFFFAOYSA-N 558221 3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenol::US11365192, Example 13-1 Cytochrome P450 4F2 34.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558221&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487827 471698879 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178733 Oc1ccccc1CCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C16H15N3O2/c20-16-4-2-1-3-12(16)8-10-21-13-5-6-14(17-11-13)15-7-9-18-19-15/h1-7,9,11,20H,8,10H2,(H,18,19) SFLUDKZZSJOIDM-UHFFFAOYSA-N 558222 US11365192, Example 13-2 Cytochrome P450 4F2 13.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558222&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112525 471698880 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178847 OC1(CCC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H19N3O2/c23-19(8-2-9-19)15-4-1-3-14(11-15)13-24-16-5-6-17(20-12-16)18-7-10-21-22-18/h1,3-7,10-12,23H,2,8-9,13H2,(H,21,22) NIPMHPQATRFRGP-UHFFFAOYSA-N 558279 US11365192, Example 27-3 Cytochrome P450 4F2 350 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558279&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148633516 471698935 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178849 OC1(CCCC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H21N3O2/c24-20(9-1-2-10-20)16-5-3-4-15(12-16)14-25-17-6-7-18(21-13-17)19-8-11-22-23-19/h3-8,11-13,24H,1-2,9-10,14H2,(H,22,23) XWZLXPQBTHRRCV-UHFFFAOYSA-N 558280 US11365192, Example 27-4 Cytochrome P450 4F2 120 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558280&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149302262 471698936 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178851 CC(C)(O)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1F InChI=1S/C18H18FN3O2/c1-18(2,23)14-9-12(3-5-15(14)19)11-24-13-4-6-16(20-10-13)17-7-8-21-22-17/h3-10,23H,11H2,1-2H3,(H,21,22) GZDWVUGQSDACBQ-UHFFFAOYSA-N 558281 US11365192, Example 27-5 Cytochrome P450 4F2 900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558281&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147734895 471698937 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178853 OC(=O)[C@H]1C[C@@](O)(C1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558282 3-Hydroxy-3-[3-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-cyclobutanecarboxylic Acid::US11365192, Example 28-1 Cytochrome P450 4F2 470 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558282&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658391 471698938 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178855 OC(=O)[C@H]1C[C@@](O)(C1)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1F 558283 US11365192, Example 28-2 Cytochrome P450 4F2 1000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558283&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323846 471698939 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178857 OC(=O)c1cccc(CCCOc2ccc(nc2)-c2ccn[nH]2)n1 InChI=1S/C17H16N4O3/c22-17(23)16-5-1-3-12(20-16)4-2-10-24-13-6-7-14(18-11-13)15-8-9-19-21-15/h1,3,5-9,11H,2,4,10H2,(H,19,21)(H,22,23) KARBHAAKDFVWHQ-UHFFFAOYSA-N 558284 6-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]propyl]-2-pyridinecarboxylic Acid::US11365192, Example 29-1 Cytochrome P450 4F2 4000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558284&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526882 471698940 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178859 OC(=O)c1ccnc(CCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H16N4O3/c22-17(23)12-5-7-18-13(10-12)2-1-9-24-14-3-4-15(19-11-14)16-6-8-20-21-16/h3-8,10-11H,1-2,9H2,(H,20,21)(H,22,23) LEHVCLWLSYBSTR-UHFFFAOYSA-N 558285 2-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]propyl]-4-pyridinecarboxylic Acid::US11365192, Example 29-2 Cytochrome P450 4F2 2700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558285&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526840 471698941 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178861 OC(=O)c1ncc(CCCCOc2ccc(nc2)-c2ccn[nH]2)cn1 InChI=1S/C17H17N5O3/c23-17(24)16-19-9-12(10-20-16)3-1-2-8-25-13-4-5-14(18-11-13)15-6-7-21-22-15/h4-7,9-11H,1-3,8H2,(H,21,22)(H,23,24) CQXKAVDINWWNAC-UHFFFAOYSA-N 558286 US11365192, Example 29-3 Cytochrome P450 4F2 84.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558286&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112537 471698942 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178863 OC(=O)c1ccc(CCCCOc2ccc(nc2)-c2ccn[nH]2)cn1 InChI=1S/C18H18N4O3/c23-18(24)17-6-4-13(11-19-17)3-1-2-10-25-14-5-7-15(20-12-14)16-8-9-21-22-16/h4-9,11-12H,1-3,10H2,(H,21,22)(H,23,24) AESDKANXJJFGMA-UHFFFAOYSA-N 558287 US11365192, Example 29-4 Cytochrome P450 4F2 240 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558287&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112538 471698943 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178865 OC(=O)c1cccc(CCCCOc2ccc(nc2)-c2ccn[nH]2)n1 InChI=1S/C18H18N4O3/c23-18(24)17-6-3-5-13(21-17)4-1-2-11-25-14-7-8-15(19-12-14)16-9-10-20-22-16/h3,5-10,12H,1-2,4,11H2,(H,20,22)(H,23,24) SKOJKKKJWQUWQH-UHFFFAOYSA-N 558288 US11365192, Example 29-5 Cytochrome P450 4F2 690 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558288&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112539 471698944 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178867 OC(=O)CCCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H19N3O3/c23-19(24)6-2-4-14-3-1-5-15(11-14)13-25-16-7-8-17(20-12-16)18-9-10-21-22-18/h1,3,5,7-12H,2,4,6,13H2,(H,21,22)(H,23,24) HDZUBTKUDHSTGW-UHFFFAOYSA-N 558289 4-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]butanoic Acid::US11365192, Example 30-1 Cytochrome P450 4F2 1400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558289&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142527001 471698945 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178869 CC(=O)N1CCC(CCCCCCO)(C1)C(=O)OC(C)(C)C InChI=1S/C17H31NO4/c1-14(20)18-11-10-17(13-18,9-7-5-6-8-12-19)15(21)22-16(2,3)4/h19H,5-13H2,1-4H3 BYDAVCJDZHKZTC-UHFFFAOYSA-N 558290 US11365192, Example 30-2 Cytochrome P450 4F2 190 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558290&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323851 471698946 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178871 OC(=O)CCc1cccc(CCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H21N3O3/c24-20(25)9-6-16-4-1-3-15(13-16)5-2-12-26-17-7-8-18(21-14-17)19-10-11-22-23-19/h1,3-4,7-8,10-11,13-14H,2,5-6,9,12H2,(H,22,23)(H,24,25) UTIFQKUKSZXQIA-UHFFFAOYSA-N 558291 3-[3-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]propyl]phenyl]propanoic Acid::US11365192, Example 30-3 Cytochrome P450 4F2 370 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558291&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526753 471698947 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178873 OC(=O)CCCc1cccc(CCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H23N3O3/c25-21(26)8-2-6-16-4-1-5-17(14-16)7-3-13-27-18-9-10-19(22-15-18)20-11-12-23-24-20/h1,4-5,9-12,14-15H,2-3,6-8,13H2,(H,23,24)(H,25,26) ZJXSWINSIBSDDU-UHFFFAOYSA-N 558292 US11365192, Example 30-4 Cytochrome P450 4F2 350 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558292&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112540 471698948 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178875 OC(=O)CCCc1ccc(CCCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C21H23N3O3/c25-21(26)5-1-3-16-6-8-17(9-7-16)4-2-14-27-18-10-11-19(22-15-18)20-12-13-23-24-20/h6-13,15H,1-5,14H2,(H,23,24)(H,25,26) QUZIDXCKPOQQKI-UHFFFAOYSA-N 558293 US11365192, Example 30-5 Cytochrome P450 4F2 74.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558293&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112541 471698949 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178877 OC(=O)c1cccc(c1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H17N3O3/c26-22(27)18-6-2-5-17(12-18)16-4-1-3-15(11-16)14-28-19-7-8-20(23-13-19)21-9-10-24-25-21/h1-13H,14H2,(H,24,25)(H,26,27) ZSQSOAYHQYPVGJ-UHFFFAOYSA-N 558294 3-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]benzoic Acid::US11365192, Example 31-1 Cytochrome P450 4F2 110 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558294&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526608 471698950 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178879 OC(=O)c1ccc(cc1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H17N3O3/c26-22(27)17-6-4-16(5-7-17)18-3-1-2-15(12-18)14-28-19-8-9-20(23-13-19)21-10-11-24-25-21/h1-13H,14H2,(H,24,25)(H,26,27) ARBJJCMKNJUHJM-UHFFFAOYSA-N 558295 US11365192, Example 31-2 Cytochrome P450 4F2 100.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558295&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112542 471698951 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178881 OC(=O)c1ccc(cn1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H16N4O3/c26-21(27)20-6-4-16(11-22-20)15-3-1-2-14(10-15)13-28-17-5-7-18(23-12-17)19-8-9-24-25-19/h1-12H,13H2,(H,24,25)(H,26,27) YRVBXSIXZLKJJB-UHFFFAOYSA-N 558296 5-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-2-pyridinecarboxylic Acid::US11365192, Example 31-3 Cytochrome P450 4F2 180 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558296&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112543 471698952 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178883 OC(=O)c1cncc(c1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H16N4O3/c26-21(27)17-9-16(10-22-11-17)15-3-1-2-14(8-15)13-28-18-4-5-19(23-12-18)20-6-7-24-25-20/h1-12H,13H2,(H,24,25)(H,26,27) ZLNSXZCDAAFBNX-UHFFFAOYSA-N 558297 US11365192, Example 31-4 Cytochrome P450 4F2 390 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558297&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149525252 471698953 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178885 OC(=O)Cc1cccc(CCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H19N3O3/c23-19(24)12-15-4-1-3-14(11-15)5-2-10-25-16-6-7-17(20-13-16)18-8-9-21-22-18/h1,3-4,6-9,11,13H,2,5,10,12H2,(H,21,22)(H,23,24) MNKZKCUNSLZLHS-UHFFFAOYSA-N 558298 2-[3-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]propyl]phenyl]acetic Acid::US11365192, Example 32-1 Cytochrome P450 4F2 430 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558298&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526546 471698954 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178887 CC(C)(C(O)=O)c1cccc(CCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H23N3O3/c1-21(2,20(25)26)16-7-3-5-15(13-16)6-4-12-27-17-8-9-18(22-14-17)19-10-11-23-24-19/h3,5,7-11,13-14H,4,6,12H2,1-2H3,(H,23,24)(H,25,26) TXTNYSMRKKUSMS-UHFFFAOYSA-N 558299 US11365192, Example 32-2 Cytochrome P450 4F2 1300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558299&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324063 471698955 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178889 CC(=O)N1CCC(CC1)(C(O)=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C23H24N4O4/c1-16(28)27-11-8-23(9-12-27,22(29)30)18-4-2-3-17(13-18)15-31-19-5-6-20(24-14-19)21-7-10-25-26-21/h2-7,10,13-14H,8-9,11-12,15H2,1H3,(H,25,26)(H,29,30) DIQQBZCPVNKMQR-UHFFFAOYSA-N 558300 1-Acetyl-4-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-4-piperidinecarboxylic Acid::US11365192, Example 33-1 Cytochrome P450 4F2 7000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558300&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112544 471698956 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178891 CCOC(=O)C(CC)(CC)CCCCO InChI=1S/C12H24O3/c1-4-12(5-2,9-7-8-10-13)11(14)15-6-3/h13H,4-10H2,1-3H3 UOURTDJOYBUREO-UHFFFAOYSA-N 558301 4-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-4-oxanecarboxylic Acid::US11365192, Example 33-2 Cytochrome P450 4F2 14000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558301&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323809 471698957 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178893 OC(=O)C1CCN(CC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H22N4O3/c26-21(27)16-7-10-25(11-8-16)17-3-1-2-15(12-17)14-28-18-4-5-19(22-13-18)20-6-9-23-24-20/h1-6,9,12-13,16H,7-8,10-11,14H2,(H,23,24)(H,26,27) YYEAELBGPNUOIV-UHFFFAOYSA-N 558302 1-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-4-piperidinecarboxylic Acid::US11365192, Example 34-1 Cytochrome P450 4F2 4100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558302&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526604 471698958 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178895 CCOC(=O)C(C)(C)CCCCCCO InChI=1S/C12H24O3/c1-4-15-11(14)12(2,3)9-7-5-6-8-10-13/h13H,4-10H2,1-3H3 RDBZMNVYUUJJJK-UHFFFAOYSA-N 558303 US11365192, Example 34-2 Cytochrome P450 4F2 11000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558303&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 154931182 471698959 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178897 COC(=O)C1(CCCCCCO)CCCC1 InChI=1S/C13H24O3/c1-16-12(15)13(9-5-6-10-13)8-4-2-3-7-11-14/h14H,2-11H2,1H3 UHIMNTQFSNNEBT-UHFFFAOYSA-N 558304 1-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-4-pyrazolecarboxylic Acid::US11365192, Example 34-3 Cytochrome P450 4F2 390 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558304&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 152911759 471698960 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178899 OC(=O)CN1C=C(CCCOc2ccc(nc2)-c2ccn[nH]2)[O]=N1 InChI=1S/C15H16N5O4/c21-15(22)10-20-9-12(24-19-20)2-1-7-23-11-3-4-13(16-8-11)14-5-6-17-18-14/h3-6,8-9H,1-2,7,10H2,(H,17,18)(H,21,22) HVWAWQOCCUBWMP-UHFFFAOYSA-N 558305 2-[4-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]propyl]-1-triazolyl]acetic Acid::US11365192, Example 35-1 Cytochrome P450 4F2 20000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558305&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526760 471698961 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178901 OC(=O)Cn1cc(CCCCOc2ccc(nc2)-c2ccn[nH]2)nn1 InChI=1S/C16H18N6O3/c23-16(24)11-22-10-12(19-21-22)3-1-2-8-25-13-4-5-14(17-9-13)15-6-7-18-20-15/h4-7,9-10H,1-3,8,11H2,(H,18,20)(H,23,24) LDJSUFKXQYXPNX-UHFFFAOYSA-N 558306 US11365192, Example 35-2 Cytochrome P450 4F2 5700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558306&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112545 471698962 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178735 COC(=O)c1ncc(cn1)-c1cccc(CBr)c1 InChI=1S/C13H11BrN2O2/c1-18-13(17)12-15-7-11(8-16-12)10-4-2-3-9(5-10)6-14/h2-5,7-8H,6H2,1H3 HADBJSYKZRFZDC-UHFFFAOYSA-N 558223 US11365192, Example 13-3 Cytochrome P450 4F2 19.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558223&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323807 471698881 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178903 CC(C)(C(O)=O)n1cc(CCCCOc2ccc(nc2)-c2ccn[nH]2)nn1 InChI=1S/C18H22N6O3/c1-18(2,17(25)26)24-12-13(21-23-24)5-3-4-10-27-14-6-7-15(19-11-14)16-8-9-20-22-16/h6-9,11-12H,3-5,10H2,1-2H3,(H,20,22)(H,25,26) LVJOUTJNQPDUPZ-UHFFFAOYSA-N 558307 US11365192, Example 35-3 Cytochrome P450 4F2 7400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558307&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112546 471698963 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178905 CC(C)(O)CS(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H21N3O4S/c1-19(2,23)13-27(24,25)16-5-3-4-14(10-16)12-26-15-6-7-17(20-11-15)18-8-9-21-22-18/h3-11,23H,12-13H2,1-2H3,(H,21,22) MTILQKIHXABZFP-UHFFFAOYSA-N 558308 2-Methyl-1-[3-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl] sulfonyl-2-propanol::US11365192, Example 36-1 Cytochrome P450 4F2 93.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558308&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658395 471698964 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178907 CC(C)(CCCS(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C22H25N3O5S/c1-22(2,21(26)27)10-4-12-31(28,29)18-6-3-5-16(13-18)15-30-17-7-8-19(23-14-17)20-9-11-24-25-20/h3,5-9,11,13-14H,4,10,12,15H2,1-2H3,(H,24,25)(H,26,27) JNDHYNIQOJQCTJ-UHFFFAOYSA-N 558309 2,2-Dimethyl-5-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl] sulfonylpentanoic Acid::US11365192, Example 37-1 Cytochrome P450 4F2 32.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558309&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112547 471698965 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178909 OC(=O)CCc1cccc(COc2cnc(-c3ccn[nH]3)c(F)c2)c1 InChI=1S/C18H16FN3O3/c19-15-9-14(10-20-18(15)16-6-7-21-22-16)25-11-13-3-1-2-12(8-13)4-5-17(23)24/h1-3,6-10H,4-5,11H2,(H,21,22)(H,23,24) AIBJCRMSRIAMEG-UHFFFAOYSA-N 558310 3-[3-[[5-Fluoro-6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]propanoic Acid::US11365192, Example 38-1 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558310&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112548 471698966 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178911 CCOC(=O)C(C)(C)OCCCCOCCCCO InChI=1S/C14H28O5/c1-4-18-13(16)14(2,3)19-12-8-7-11-17-10-6-5-9-15/h15H,4-12H2,1-3H3 ZAUXCKHWTDXZHV-UHFFFAOYSA-N 558311 2-[3-[[6-(1H-Pyrazol-4-yl)-3-pyridinyl]oxymethyl]phenyl]acetic Acid::US11365192, Example 38-2 Cytochrome P450 4F2 19000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558311&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323811 471698967 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178913 Cc1cn[nH]c1-c1ccc(OCC23CCC(CC2)(CC3)C(O)=O)cn1 InChI=1S/C19H23N3O3/c1-13-10-21-22-16(13)15-3-2-14(11-20-15)25-12-18-4-7-19(8-5-18,9-6-18)17(23)24/h2-3,10-11H,4-9,12H2,1H3,(H,21,22)(H,23,24) UHGPZULGGHQAKM-UHFFFAOYSA-N 558312 1-[[6-(4-Methyl-1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-4-bicyclo[2.2.2]octanecarboxylic Acid::US11365192, Example 38-3 Cytochrome P450 4F2 17000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558312&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526866 471698968 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178915 OC(=O)Cc1cccc(COc2ccc(nc2)-c2ccns2)c1 InChI=1S/C17H14N2O3S/c20-17(21)9-12-2-1-3-13(8-12)11-22-14-4-5-15(18-10-14)16-6-7-19-23-16/h1-8,10H,9,11H2,(H,20,21) UZXOQAPTMMTUTO-UHFFFAOYSA-N 558313 2-[3-[[6-(5-Isothiazolyl)-3-pyridinyl]oxymethyl]phenyl]acetic Acid::US11365192, Example 39-1 Cytochrome P450 4F2 13000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558313&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487849 471698969 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178917 OC(=O)C12CCC(COc3ccc(nc3)-c3ccns3)(CC1)CC2 InChI=1S/C18H20N2O3S/c21-16(22)18-7-4-17(5-8-18,6-9-18)12-23-13-1-2-14(19-11-13)15-3-10-20-24-15/h1-3,10-11H,4-9,12H2,(H,21,22) LBGZWODCDWPFHO-UHFFFAOYSA-N 558314 US11365192, Example 39-2 Cytochrome P450 4F2 22000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558314&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323850 471698970 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178919 OC(=O)Cc1cccc(COc2ccc(nc2)-c2cnco2)c1 InChI=1S/C17H14N2O4/c20-17(21)7-12-2-1-3-13(6-12)10-22-14-4-5-15(19-8-14)16-9-18-11-23-16/h1-6,8-9,11H,7,10H2,(H,20,21) XCZQJDOIYQZZNP-UHFFFAOYSA-N 558315 2-[3-[[6-(5-Oxazolyl)-3-pyridinyl]oxymethyl]phenyl]acetic Acid::US11365192, Example 40-1 Cytochrome P450 4F2 28000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558315&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526536 471698971 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178921 CC(C)OC(=O)c1ccc(CCO)cc1 InChI=1S/C12H16O3/c1-9(2)15-12(14)11-5-3-10(4-6-11)7-8-13/h3-6,9,13H,7-8H2,1-2H3 WIDHWQILWBCUKR-UHFFFAOYSA-N 558316 US11365192, Example 40-2 Cytochrome P450 4F2 8200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558316&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 53946588 471698972 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178923 O=C(N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1)c1cccc(c1)S(=O)=O 558317 3-[Oxo-[(3R)-3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-piperidinyl]methyl]benzenesulfonamide::US11365192, Example 41-1 Cytochrome P450 4F2 590 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558317&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112549 471698973 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178925 COC(=O)C\C=C\c1cccc(CCO)c1 InChI=1S/C13H16O3/c1-16-13(15)7-3-6-11-4-2-5-12(10-11)8-9-14/h2-6,10,14H,7-9H2,1H3/b6-3+ JHPALRCEFQBCKH-ZZXKWVIFSA-N 558318 US11365192, Example 41-2 Cytochrome P450 4F2 450 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558318&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487834 471698974 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178927 COC(=O)C\C=C\c1ccc(CCO)cc1 InChI=1S/C13H16O3/c1-16-13(15)4-2-3-11-5-7-12(8-6-11)9-10-14/h2-3,5-8,14H,4,9-10H2,1H3/b3-2+ HTHZNDZGLKJYQY-NSCUHMNNSA-N 558319 US11365192, Example 41-3 Cytochrome P450 4F2 4300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558319&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487835 471698975 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178929 O=C(N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1)C1=CC=C[C](=O)=N1 558320 US11365192, Example 41-4 Cytochrome P450 4F2 1500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558320&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323983 471698976 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178931 CCS(=O)(=O)NCC(=O)N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1 558321 US11365192, Example 41-5 Cytochrome P450 4F2 550 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558321&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323856 471698977 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178933 NS(=O)(=O)CCCC(=O)N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1 558322 US11365192, Example 41-6 Cytochrome P450 4F2 320 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558322&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324007 471698978 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178935 CNC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H16N4O2/c1-18-17(22)13-4-2-3-12(9-13)11-23-14-5-6-15(19-10-14)16-7-8-20-21-16/h2-10H,11H2,1H3,(H,18,22)(H,20,21) PFYBVTVXIFIFQB-UHFFFAOYSA-N 558323 N-Methyl-3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]benzamide::US11365192, Example 42-1 Cytochrome P450 4F2 76.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558323&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112551 471698979 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178937 CCCNC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H20N4O2/c1-2-9-20-19(24)15-5-3-4-14(11-15)13-25-16-6-7-17(21-12-16)18-8-10-22-23-18/h3-8,10-12H,2,9,13H2,1H3,(H,20,24)(H,22,23) COLXRJSXJIVWJY-UHFFFAOYSA-N 558324 US11365192, Example 42-2 Cytochrome P450 4F2 25.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558324&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147260569 471698980 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178939 OCCNC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H18N4O3/c23-9-8-19-18(24)14-3-1-2-13(10-14)12-25-15-4-5-16(20-11-15)17-6-7-21-22-17/h1-7,10-11,23H,8-9,12H2,(H,19,24)(H,21,22) WZHZTMRKRQOQSS-UHFFFAOYSA-N 558325 US11365192, Example 42-3 Cytochrome P450 4F2 210 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558325&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323900 471698981 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178941 CNC(=O)Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H18N4O2/c1-19-18(23)10-13-3-2-4-14(9-13)12-24-15-5-6-16(20-11-15)17-7-8-21-22-17/h2-9,11H,10,12H2,1H3,(H,19,23)(H,21,22) WUPBKUNRYFWWCP-UHFFFAOYSA-N 558326 US11365192, Example 42-4 Cytochrome P450 4F2 12.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558326&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 153257661 471698982 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178943 CN(C)C(=O)Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H20N4O2/c1-23(2)19(24)11-14-4-3-5-15(10-14)13-25-16-6-7-17(20-12-16)18-8-9-21-22-18/h3-10,12H,11,13H2,1-2H3,(H,21,22) IXWGCDLMTOMELB-UHFFFAOYSA-N 558327 US11365192, Example 42-5 Cytochrome P450 4F2 260 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558327&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323909 471698983 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178945 CCCNC(=O)Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H22N4O2/c1-2-9-21-20(25)12-15-4-3-5-16(11-15)14-26-17-6-7-18(22-13-17)19-8-10-23-24-19/h3-8,10-11,13H,2,9,12,14H2,1H3,(H,21,25)(H,23,24) YVMWAUPXGDVLLV-UHFFFAOYSA-N 558328 US11365192, Example 42-6 Cytochrome P450 4F2 97.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558328&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149439717 471698984 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178947 OCCNC(=O)Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H20N4O3/c24-9-8-20-19(25)11-14-2-1-3-15(10-14)13-26-16-4-5-17(21-12-16)18-6-7-22-23-18/h1-7,10,12,24H,8-9,11,13H2,(H,20,25)(H,22,23) UJMDMVKPXFXOQP-UHFFFAOYSA-N 558329 US11365192, Example 42-7 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558329&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323858 471698985 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178949 CNC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H20N4O2/c1-20-19(24)8-5-14-3-2-4-15(11-14)13-25-16-6-7-17(21-12-16)18-9-10-22-23-18/h2-4,6-7,9-12H,5,8,13H2,1H3,(H,20,24)(H,22,23) CTQXFBQVAJNLDW-UHFFFAOYSA-N 558330 US11365192, Example 42-8 Cytochrome P450 4F2 70.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558330&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147288233 471698986 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178951 CN(C)C(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H22N4O2/c1-24(2)20(25)9-6-15-4-3-5-16(12-15)14-26-17-7-8-18(21-13-17)19-10-11-22-23-19/h3-5,7-8,10-13H,6,9,14H2,1-2H3,(H,22,23) GCXKUDXMXUMZMN-UHFFFAOYSA-N 558331 US11365192, Example 42-9 Cytochrome P450 4F2 76.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558331&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147615871 471698987 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178953 CCCNC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H24N4O2/c1-2-11-22-21(26)9-6-16-4-3-5-17(13-16)15-27-18-7-8-19(23-14-18)20-10-12-24-25-20/h3-5,7-8,10,12-14H,2,6,9,11,15H2,1H3,(H,22,26)(H,24,25) FQFVZEKZXQZFMO-UHFFFAOYSA-N 558332 US11365192, Example 42-10 Cytochrome P450 4F2 15.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558332&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147548142 471698988 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178955 OCCNC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H22N4O3/c25-11-10-21-20(26)7-4-15-2-1-3-16(12-15)14-27-17-5-6-18(22-13-17)19-8-9-23-24-19/h1-3,5-6,8-9,12-13,25H,4,7,10-11,14H2,(H,21,26)(H,23,24) IASYQUONNJCIOL-UHFFFAOYSA-N 558333 US11365192, Example 42-11 Cytochrome P450 4F2 95.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558333&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147882701 471698989 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178957 O=C(CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)N1CCC1 InChI=1S/C21H22N4O2/c26-21(25-11-2-12-25)8-5-16-3-1-4-17(13-16)15-27-18-6-7-19(22-14-18)20-9-10-23-24-20/h1,3-4,6-7,9-10,13-14H,2,5,8,11-12,15H2,(H,23,24) CAUGXBWPEURKGC-UHFFFAOYSA-N 558334 US11365192, Example 42-12 Cytochrome P450 4F2 42.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558334&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147187579 471698990 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178959 O=C(CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)N1CCCC1 InChI=1S/C22H24N4O2/c27-22(26-12-1-2-13-26)9-6-17-4-3-5-18(14-17)16-28-19-7-8-20(23-15-19)21-10-11-24-25-21/h3-5,7-8,10-11,14-15H,1-2,6,9,12-13,16H2,(H,24,25) XWZDFZMIVBZMCS-UHFFFAOYSA-N 558335 US11365192, Example 42-13 Cytochrome P450 4F2 15.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558335&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149302194 471698991 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178961 O=C(CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)N1CCCCC1 InChI=1S/C23H26N4O2/c28-23(27-13-2-1-3-14-27)10-7-18-5-4-6-19(15-18)17-29-20-8-9-21(24-16-20)22-11-12-25-26-22/h4-6,8-9,11-12,15-16H,1-3,7,10,13-14,17H2,(H,25,26) VAXMBMRWGFMCCR-UHFFFAOYSA-N 558336 US11365192, Example 42-14 Cytochrome P450 4F2 30.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558336&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 153015611 471698992 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178963 O=C(CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)N1CCOCC1 InChI=1S/C22H24N4O3/c27-22(26-10-12-28-13-11-26)7-4-17-2-1-3-18(14-17)16-29-19-5-6-20(23-15-19)21-8-9-24-25-21/h1-3,5-6,8-9,14-15H,4,7,10-13,16H2,(H,24,25) NLLSAOWEJXCBNY-UHFFFAOYSA-N 558337 US11365192, Example 42-15 Cytochrome P450 4F2 140 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558337&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148648583 471698993 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178965 CN(C)C(=O)\C=C\c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H20N4O2/c1-24(2)20(25)9-6-15-4-3-5-16(12-15)14-26-17-7-8-18(21-13-17)19-10-11-22-23-19/h3-13H,14H2,1-2H3,(H,22,23)/b9-6+ ZSWFOIGPAOWNRR-RMKNXTFCSA-N 558338 US11365192, Example 42-16 Cytochrome P450 4F2 5.70 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558338&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149564394 471698994 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178967 Fc1cc(OCc2cccc(CCC(=O)N3CCC3)c2)cnc1-c1ccn[nH]1 InChI=1S/C21H21FN4O2/c22-18-12-17(13-23-21(18)19-7-8-24-25-19)28-14-16-4-1-3-15(11-16)5-6-20(27)26-9-2-10-26/h1,3-4,7-8,11-13H,2,5-6,9-10,14H2,(H,24,25) NTXGGQIEUKKKRW-UHFFFAOYSA-N 558339 US11365192, Example 42-17 Cytochrome P450 4F2 12.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558339&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324035 471698995 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178969 OCCNC(=O)CCc1cccc(COc2cnc(-c3ccn[nH]3)c(F)c2)c1 InChI=1S/C20H21FN4O3/c21-17-11-16(12-23-20(17)18-6-7-24-25-18)28-13-15-3-1-2-14(10-15)4-5-19(27)22-8-9-26/h1-3,6-7,10-12,26H,4-5,8-9,13H2,(H,22,27)(H,24,25) CIZBTIVPSLKHLQ-UHFFFAOYSA-N 558340 US11365192, Example 42-18 Cytochrome P450 4F2 21.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558340&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324013 471698996 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178971 OC1CN(C1)C(=O)CCc1cccc(COc2cnc(-c3ccn[nH]3)c(F)c2)c1 InChI=1S/C21H21FN4O3/c22-18-9-17(10-23-21(18)19-6-7-24-25-19)29-13-15-3-1-2-14(8-15)4-5-20(28)26-11-16(27)12-26/h1-3,6-10,16,27H,4-5,11-13H2,(H,24,25) UYFPGVBHCPJFCE-UHFFFAOYSA-N 558341 US11365192, Example 42-19 Cytochrome P450 4F2 47.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558341&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324069 471698997 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178973 Fc1cc(OCc2cccc(CCC(=O)NC3COC3)c2)cnc1-c1ccn[nH]1 InChI=1S/C21H21FN4O3/c22-18-9-17(10-23-21(18)19-6-7-24-26-19)29-11-15-3-1-2-14(8-15)4-5-20(27)25-16-12-28-13-16/h1-3,6-10,16H,4-5,11-13H2,(H,24,26)(H,25,27) YFPJHGALSSSFLZ-UHFFFAOYSA-N 558342 US11365192, Example 42-20 Cytochrome P450 4F2 11.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558342&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324011 471698998 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178975 CN(C)C(=O)[C@H]1C[C@@](O)(C1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558343 US11365192, Example 42-21 Cytochrome P450 4F2 28.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558343&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149385062 471698999 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178977 CN(C)C(=O)[C@H]1C[C@@](O)(C1)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1F 558344 US11365192, Example 42-22 Cytochrome P450 4F2 99.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558344&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323913 471699000 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178979 CNC(=O)C(C)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558345 US11365192, Example 42-23 Cytochrome P450 4F2 55.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558345&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324068 471699001 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178981 CNC(=O)C(C)(C)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H22N4O2/c1-20(2,19(25)21-3)15-6-4-5-14(11-15)13-26-16-7-8-17(22-12-16)18-9-10-23-24-18/h4-12H,13H2,1-3H3,(H,21,25)(H,23,24) HPUCBLQFKBMXOQ-UHFFFAOYSA-N 558346 US11365192, Example 42-24 Cytochrome P450 4F2 150 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558346&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323862 471699002 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178983 FC1CN(C1)C(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H21FN4O2/c22-17-12-26(13-17)21(27)7-4-15-2-1-3-16(10-15)14-28-18-5-6-19(23-11-18)20-8-9-24-25-20/h1-3,5-6,8-11,17H,4,7,12-14H2,(H,24,25) VZVPIMGEZGVFPF-UHFFFAOYSA-N 558347 1-(3-Fluoro-1-azetidinyl)-3-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-propanone::US11365192, Example 43-1 Cytochrome P450 4F2 52.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558347&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487865 471699003 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178985 FC1(F)CN(C1)C(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H20F2N4O2/c22-21(23)13-27(14-21)20(28)7-4-15-2-1-3-16(10-15)12-29-17-5-6-18(24-11-17)19-8-9-25-26-19/h1-3,5-6,8-11H,4,7,12-14H2,(H,25,26) UFLRLFGWXKGRCE-UHFFFAOYSA-N 558348 US11365192, Example 43-2 Cytochrome P450 4F2 48.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558348&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 152901702 471699004 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178987 CN(CCO)C(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H24N4O3/c1-25(11-12-26)21(27)8-5-16-3-2-4-17(13-16)15-28-18-6-7-19(22-14-18)20-9-10-23-24-20/h2-4,6-7,9-10,13-14,26H,5,8,11-12,15H2,1H3,(H,23,24) YCAQZBIZBUOGJL-UHFFFAOYSA-N 558349 US11365192, Example 43-3 Cytochrome P450 4F2 170 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558349&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149329527 471699005 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178989 O=C(CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)NC1COC1 InChI=1S/C21H22N4O3/c26-21(24-17-13-27-14-17)7-4-15-2-1-3-16(10-15)12-28-18-5-6-19(22-11-18)20-8-9-23-25-20/h1-3,5-6,8-11,17H,4,7,12-14H2,(H,23,25)(H,24,26) QHIOSBYGOYAOMZ-UHFFFAOYSA-N 558350 US11365192, Example 43-4 Cytochrome P450 4F2 45.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558350&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149039774 471699006 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178991 COCCNC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H24N4O3/c1-27-12-11-22-21(26)8-5-16-3-2-4-17(13-16)15-28-18-6-7-19(23-14-18)20-9-10-24-25-20/h2-4,6-7,9-10,13-14H,5,8,11-12,15H2,1H3,(H,22,26)(H,24,25) PRCZQZDXBUKBQU-UHFFFAOYSA-N 558351 US11365192, Example 43-5 Cytochrome P450 4F2 40.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558351&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148957362 471699007 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178993 C[C@@H](O)CNC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558352 US11365192, Example 43-6 Cytochrome P450 4F2 92.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558352&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324024 471699008 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178995 C[C@@H](CO)NC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558353 US11365192, Example 43-7 Cytochrome P450 4F2 63.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558353&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323861 471699009 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178997 C[C@H](CO)NC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558354 US11365192, Example 43-8 Cytochrome P450 4F2 120 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558354&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324070 471699010 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178999 C[C@H](O)CNC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558355 US11365192, Example 43-9 Cytochrome P450 4F2 73.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558355&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324062 471699011 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179001 OC1CN(C1)C(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H22N4O3/c26-17-12-25(13-17)21(27)7-4-15-2-1-3-16(10-15)14-28-18-5-6-19(22-11-18)20-8-9-23-24-20/h1-3,5-6,8-11,17,26H,4,7,12-14H2,(H,23,24) BAGTZDHGDKFUED-UHFFFAOYSA-N 558356 US11365192, Example 43-10 Cytochrome P450 4F2 190 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558356&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147045420 471699012 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179003 O=C(CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)NCC(=O)N1CCCC1 InChI=1S/C24H27N5O3/c30-23(26-16-24(31)29-12-1-2-13-29)9-6-18-4-3-5-19(14-18)17-32-20-7-8-21(25-15-20)22-10-11-27-28-22/h3-5,7-8,10-11,14-15H,1-2,6,9,12-13,16-17H2,(H,26,30)(H,27,28) OKAVATDTXYCERJ-UHFFFAOYSA-N 558357 US11365192, Example 43-11 Cytochrome P450 4F2 32.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558357&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148779639 471699013 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179005 CO[C@H](C)CNC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558358 US11365192, Example 43-12 Cytochrome P450 4F2 40.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558358&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324051 471699014 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179007 O=C(CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)NC[C@H]1CCCO1 558359 US11365192, Example 43-13 Cytochrome P450 4F2 21.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558359&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324046 471699015 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179009 O=C(CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)NC[C@@H]1CCCO1 558360 US11365192, Example 43-14 Cytochrome P450 4F2 18.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558360&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324028 471699016 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179011 CN(C)CCNC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H27N5O2/c1-27(2)13-12-23-22(28)9-6-17-4-3-5-18(14-17)16-29-19-7-8-20(24-15-19)21-10-11-25-26-21/h3-5,7-8,10-11,14-15H,6,9,12-13,16H2,1-2H3,(H,23,28)(H,25,26) QBOQPVXQLGRNPK-UHFFFAOYSA-N 558361 US11365192, Example 43-15 Cytochrome P450 4F2 280 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558361&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323873 471699017 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179013 CN(C)C(=O)C1CC1c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558362 US11365192, Example 43-16 Cytochrome P450 4F2 22.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558362&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 154931040 471699018 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179015 CS(=O)(=O)NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H16N4O4S/c1-26(23,24)21-17(22)13-4-2-3-12(9-13)11-25-14-5-6-15(18-10-14)16-7-8-19-20-16/h2-10H,11H2,1H3,(H,19,20)(H,21,22) OEZMXGDGOMLFQJ-UHFFFAOYSA-N 558363 N-Methylsulfonyl-3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]benzamide::US11365192, Example 44-1 Cytochrome P450 4F2 7500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558363&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526995 471699019 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179017 CCOC(=O)CCc1ccccc1CO InChI=1S/C12H16O3/c1-2-15-12(14)8-7-10-5-3-4-6-11(10)9-13/h3-6,13H,2,7-9H2,1H3 QVTBWVDNLJSFAS-UHFFFAOYSA-N 558364 US11365192, Example 44-2 Cytochrome P450 4F2 73.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558364&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 12241434 471699020 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179019 CS(=O)(=O)NC(=O)Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H18N4O4S/c1-27(24,25)22-18(23)10-13-3-2-4-14(9-13)12-26-15-5-6-16(19-11-15)17-7-8-20-21-17/h2-9,11H,10,12H2,1H3,(H,20,21)(H,22,23) PHXDGHBTMVEBTA-UHFFFAOYSA-N 558365 US11365192, Example 44-3 Cytochrome P450 4F2 11000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558365&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323916 471699021 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179021 CCOC(=O)CCCCc1ccccc1CO InChI=1S/C14H20O3/c1-2-17-14(16)10-6-5-8-12-7-3-4-9-13(12)11-15/h3-4,7,9,15H,2,5-6,8,10-11H2,1H3 JJQNRTRCGKNIFJ-UHFFFAOYSA-N 558366 US11365192, Example 44-4 Cytochrome P450 4F2 290 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558366&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148068612 471699022 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179023 CS(=O)(=O)NC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H20N4O4S/c1-28(25,26)23-19(24)8-5-14-3-2-4-15(11-14)13-27-16-6-7-17(20-12-16)18-9-10-21-22-18/h2-4,6-7,9-12H,5,8,13H2,1H3,(H,21,22)(H,23,24) KVWBTYLHWAXKKC-UHFFFAOYSA-N 558367 US11365192, Example 44-5 Cytochrome P450 4F2 2700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558367&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323962 471699023 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179025 CCOC(=O)CCc1ccc(CCO)cc1 InChI=1S/C13H18O3/c1-2-16-13(15)8-7-11-3-5-12(6-4-11)9-10-14/h3-6,14H,2,7-10H2,1H3 UCSFLSRDHNJGAV-UHFFFAOYSA-N 558368 US11365192, Example 44-6 Cytochrome P450 4F2 45.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558368&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 154931108 471699024 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179027 NC(=O)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccn1 InChI=1S/C15H13N5O2/c16-15(21)14-7-10(3-5-17-14)9-22-11-1-2-12(18-8-11)13-4-6-19-20-13/h1-8H,9H2,(H2,16,21)(H,19,20) KYKWZXOEISKSTH-UHFFFAOYSA-N 558369 4-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]-2-pyridinecarboxamide::US11365192, Example 44-7 Cytochrome P450 4F2 85.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558369&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526615 471699025 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179029 OC(=O)CCNC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H18N4O4/c24-18(25)7-8-20-19(26)14-3-1-2-13(10-14)12-27-15-4-5-16(21-11-15)17-6-9-22-23-17/h1-6,9-11H,7-8,12H2,(H,20,26)(H,22,23)(H,24,25) RFIFWVWJSAWHNN-UHFFFAOYSA-N 558370 3-[[Oxo-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]methyl]amino]propanoic Acid::US11365192, Example 45-1 Cytochrome P450 4F2 7600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558370&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526543 471699026 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179031 CN(CCC(O)=O)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H20N4O4/c1-24(10-8-19(25)26)20(27)15-4-2-3-14(11-15)13-28-16-5-6-17(21-12-16)18-7-9-22-23-18/h2-7,9,11-12H,8,10,13H2,1H3,(H,22,23)(H,25,26) FSSNEDLRTRQFIM-UHFFFAOYSA-N 558371 US11365192, Example 45-2 Cytochrome P450 4F2 3200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558371&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112552 471699027 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179033 CC(C)(CNC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C21H22N4O4/c1-21(2,20(27)28)13-23-19(26)15-5-3-4-14(10-15)12-29-16-6-7-17(22-11-16)18-8-9-24-25-18/h3-11H,12-13H2,1-2H3,(H,23,26)(H,24,25)(H,27,28) LCNDRHLLKRZZKN-UHFFFAOYSA-N 558372 US11365192, Example 45-3 Cytochrome P450 4F2 6100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558372&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112553 471699028 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179035 OC(=O)C1(CNC(=O)c2cccc(COc3ccc(nc3)-c3ccn[nH]3)c2)CC1 InChI=1S/C21H20N4O4/c26-19(23-13-21(7-8-21)20(27)28)15-3-1-2-14(10-15)12-29-16-4-5-17(22-11-16)18-6-9-24-25-18/h1-6,9-11H,7-8,12-13H2,(H,23,26)(H,24,25)(H,27,28) GXKJKMJDHFFEID-UHFFFAOYSA-N 558373 US11365192, Example 45-4 Cytochrome P450 4F2 6400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558373&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112554 471699029 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179037 OC(=O)C1(CNC(=O)c2cccc(COc3ccc(nc3)-c3ccn[nH]3)c2)CCCC1 InChI=1S/C23H24N4O4/c28-21(25-15-23(22(29)30)9-1-2-10-23)17-5-3-4-16(12-17)14-31-18-6-7-19(24-13-18)20-8-11-26-27-20/h3-8,11-13H,1-2,9-10,14-15H2,(H,25,28)(H,26,27)(H,29,30) AQFIOHAAOCWZBF-UHFFFAOYSA-N 558374 US11365192, Example 45-5 Cytochrome P450 4F2 750 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558374&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112555 471699030 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179039 OC(=O)C1(CNC(=O)c2cccc(COc3ccc(nc3)-c3ccn[nH]3)c2)CCOCC1 InChI=1S/C23H24N4O5/c28-21(25-15-23(22(29)30)7-10-31-11-8-23)17-3-1-2-16(12-17)14-32-18-4-5-19(24-13-18)20-6-9-26-27-20/h1-6,9,12-13H,7-8,10-11,14-15H2,(H,25,28)(H,26,27)(H,29,30) WGBICTNDPVTQIN-UHFFFAOYSA-N 558375 US11365192, Example 45-6 Cytochrome P450 4F2 4500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558375&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112556 471699031 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179041 OC(=O)C[C@H](NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)c1ccccc1 558376 US11365192, Example 45-7 Cytochrome P450 4F2 2900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558376&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112557 471699032 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179043 OC(=O)C[C@@H](NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)c1ccccc1 558377 US11365192, Example 45-8 Cytochrome P450 4F2 1900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558377&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112558 471699033 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179045 C[C@H](NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O 558378 US11365192, Example 45-9 Cytochrome P450 4F2 4800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558378&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112559 471699034 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179047 C[C@@H](NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O 558379 US11365192, Example 45-10 Cytochrome P450 4F2 10000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558379&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112560 471699035 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179049 OC(=O)[C@H](Cc1ccccc1)NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558380 US11365192, Example 45-11 Cytochrome P450 4F2 1200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558380&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112561 471699036 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179051 OC(=O)[C@@H](Cc1ccccc1)NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558381 US11365192, Example 45-12 Cytochrome P450 4F2 890 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558381&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112562 471699037 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179053 OC(=O)C1(CCOCC1)NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H22N4O5/c27-20(25-22(21(28)29)7-10-30-11-8-22)16-3-1-2-15(12-16)14-31-17-4-5-18(23-13-17)19-6-9-24-26-19/h1-6,9,12-13H,7-8,10-11,14H2,(H,24,26)(H,25,27)(H,28,29) YETGQCLBEGAIPP-UHFFFAOYSA-N 558382 US11365192, Example 45-13 Cytochrome P450 4F2 6800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558382&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112563 471699038 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179055 CC(C)(CCNC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C22H24N4O4/c1-22(2,21(28)29)9-11-23-20(27)16-5-3-4-15(12-16)14-30-17-6-7-18(24-13-17)19-8-10-25-26-19/h3-8,10,12-13H,9,11,14H2,1-2H3,(H,23,27)(H,25,26)(H,28,29) CZDTVLABRURLJZ-UHFFFAOYSA-N 558383 US11365192, Example 45-14 Cytochrome P450 4F2 410 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558383&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112564 471699039 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179057 CC(C)(CCNC(=O)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccn1)C(O)=O InChI=1S/C21H23N5O4/c1-21(2,20(28)29)7-10-23-19(27)18-11-14(5-8-22-18)13-30-15-3-4-16(24-12-15)17-6-9-25-26-17/h3-6,8-9,11-12H,7,10,13H2,1-2H3,(H,23,27)(H,25,26)(H,28,29) CCSRCFVAKMBSKG-UHFFFAOYSA-N 558384 US11365192, Example 45-15 Cytochrome P450 4F2 180 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558384&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112565 471699040 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179059 CC(C)(CCNC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)n1)C(O)=O InChI=1S/C21H23N5O4/c1-21(2,20(28)29)9-11-22-19(27)18-5-3-4-14(25-18)13-30-15-6-7-16(23-12-15)17-8-10-24-26-17/h3-8,10,12H,9,11,13H2,1-2H3,(H,22,27)(H,24,26)(H,28,29) LQMYXBAYNLWRPA-UHFFFAOYSA-N 558385 US11365192, Example 45-16 Cytochrome P450 4F2 3400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558385&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112566 471699041 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179061 CC(C)(CCNC(=O)c1cncc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C21H23N5O4/c1-21(2,20(28)29)6-8-23-19(27)15-9-14(10-22-11-15)13-30-16-3-4-17(24-12-16)18-5-7-25-26-18/h3-5,7,9-12H,6,8,13H2,1-2H3,(H,23,27)(H,25,26)(H,28,29) HUPCCVJXROMFHF-UHFFFAOYSA-N 558386 US11365192, Example 45-17 Cytochrome P450 4F2 1000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558386&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112567 471699042 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179063 CN(CCC(C)(C)C(O)=O)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C23H26N4O4/c1-23(2,22(29)30)10-12-27(3)21(28)17-6-4-5-16(13-17)15-31-18-7-8-19(24-14-18)20-9-11-25-26-20/h4-9,11,13-14H,10,12,15H2,1-3H3,(H,25,26)(H,29,30) XUVAHENEDGUKSZ-UHFFFAOYSA-N 558387 US11365192, Example 45-18 Cytochrome P450 4F2 270 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558387&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112568 471699043 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179065 OC(=O)[C@@H]1CC[C@@H](CC1)NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558388 US11365192, Example 45-19 Cytochrome P450 4F2 13000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558388&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112569 471699044 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179067 OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558389 US11365192, Example 45-20 Cytochrome P450 4F2 2100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558389&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112569 471699045 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179069 OC(=O)[C@@H]1C[C@@H](C1)NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558390 US11365192, Example 45-21 Cytochrome P450 4F2 6100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558390&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112570 471699046 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179071 OC(=O)[C@H]1C[C@@H](C1)NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558391 US11365192, Example 45-22 Cytochrome P450 4F2 2800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558391&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112570 471699047 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179073 OC(=O)C12CC(C1)(C2)NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H20N4O4/c27-19(25-22-11-21(12-22,13-22)20(28)29)15-3-1-2-14(8-15)10-30-16-4-5-17(23-9-16)18-6-7-24-26-18/h1-9H,10-13H2,(H,24,26)(H,25,27)(H,28,29) YDYJJKYKJUYKTC-UHFFFAOYSA-N 558392 US11365192, Example 45-23 Cytochrome P450 4F2 3900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558392&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112571 471699048 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179075 OC(=O)c1ccc(CNC(=O)c2cccc(COc3ccc(nc3)-c3ccn[nH]3)c2)cc1 InChI=1S/C24H20N4O4/c29-23(26-13-16-4-6-18(7-5-16)24(30)31)19-3-1-2-17(12-19)15-32-20-8-9-21(25-14-20)22-10-11-27-28-22/h1-12,14H,13,15H2,(H,26,29)(H,27,28)(H,30,31) UAHNZJIPXCVDGW-UHFFFAOYSA-N 558393 US11365192, Example 45-24 Cytochrome P450 4F2 830 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558393&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112572 471699049 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179077 OC(=O)c1cccc(CNC(=O)c2cccc(COc3ccc(nc3)-c3ccn[nH]3)c2)c1 InChI=1S/C24H20N4O4/c29-23(26-13-16-3-1-6-19(11-16)24(30)31)18-5-2-4-17(12-18)15-32-20-7-8-21(25-14-20)22-9-10-27-28-22/h1-12,14H,13,15H2,(H,26,29)(H,27,28)(H,30,31) NPRZIBZGLQYJNY-UHFFFAOYSA-N 558394 US11365192, Example 45-25 Cytochrome P450 4F2 370 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558394&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112573 471699050 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179079 OC(=O)c1ccccc1CNC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C24H20N4O4/c29-23(26-13-18-5-1-2-7-20(18)24(30)31)17-6-3-4-16(12-17)15-32-19-8-9-21(25-14-19)22-10-11-27-28-22/h1-12,14H,13,15H2,(H,26,29)(H,27,28)(H,30,31) NYMLIKIOMPYNDB-UHFFFAOYSA-N 558395 US11365192, Example 45-26 Cytochrome P450 4F2 880 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558395&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112574 471699051 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179081 OC(=O)C1CCN(CC1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H22N4O4/c27-21(26-10-7-16(8-11-26)22(28)29)17-3-1-2-15(12-17)14-30-18-4-5-19(23-13-18)20-6-9-24-25-20/h1-6,9,12-13,16H,7-8,10-11,14H2,(H,24,25)(H,28,29) GZLJYDPAHXTVTG-UHFFFAOYSA-N 558396 US11365192, Example 45-27 Cytochrome P450 4F2 2200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558396&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112575 471699052 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179083 OC(=O)[C@@H]1CCCN(C1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558397 US11365192, Example 45-28 Cytochrome P450 4F2 3700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558397&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112576 471699053 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179085 OC(=O)[C@H]1CCCN(C1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558398 US11365192, Example 45-29 Cytochrome P450 4F2 4900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558398&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112577 471699054 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179087 OC(=O)CC1CCN(CC1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C23H24N4O4/c28-22(29)13-16-7-10-27(11-8-16)23(30)18-3-1-2-17(12-18)15-31-19-4-5-20(24-14-19)21-6-9-25-26-21/h1-6,9,12,14,16H,7-8,10-11,13,15H2,(H,25,26)(H,28,29) NUNSEFIXFONRDM-UHFFFAOYSA-N 558399 US11365192, Example 45-30 Cytochrome P450 4F2 4000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558399&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112578 471699055 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179089 OC(=O)CC1CCCN(C1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558400 US11365192, Example 45-31 Cytochrome P450 4F2 2500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558400&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112579 471699056 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179091 OC(=O)CC1CCCCN1C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558401 US11365192, Example 45-32 Cytochrome P450 4F2 6800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558401&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112580 471699057 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179093 OC(=O)C1CC2CCC(C1)N2C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558402 US11365192, Example 45-33 Cytochrome P450 4F2 19000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558402&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112581 471699058 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179095 OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558403 US11365192, Example 45-34 Cytochrome P450 4F2 17000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558403&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112582 471699059 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179097 OC(=O)[C@H]1CCCN1C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558404 US11365192, Example 45-35 Cytochrome P450 4F2 13000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558404&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112583 471699060 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179099 OC(=O)C1CCN(C1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558405 US11365192, Example 45-36 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558405&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112584 471699061 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179101 OC(=O)C1(F)CCN(C1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558406 US11365192, Example 45-37 Cytochrome P450 4F2 720 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558406&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112585 471699062 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179103 OC(=O)C1(F)CCN(C1)C(=O)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccn1 558407 US11365192, Example 45-38 Cytochrome P450 4F2 300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558407&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112586 471699063 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179105 OC(=O)C[C@H]1CCN(C1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558408 US11365192, Example 45-39 Cytochrome P450 4F2 1400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558408&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112587 471699064 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179107 OC(=O)C[C@@H]1CCN(C1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558409 US11365192, Example 45-40 Cytochrome P450 4F2 1400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558409&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112588 471699065 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179109 OC(=O)CC1CN(C1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H20N4O4/c26-20(27)9-15-11-25(12-15)21(28)16-3-1-2-14(8-16)13-29-17-4-5-18(22-10-17)19-6-7-23-24-19/h1-8,10,15H,9,11-13H2,(H,23,24)(H,26,27) BNWNXTDPHULWMB-UHFFFAOYSA-N 558410 US11365192, Example 45-41 Cytochrome P450 4F2 1800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558410&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112589 471699066 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179111 OC(=O)c1nc2CN(Cc2o1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H17N5O5/c28-21(27-10-18-19(11-27)32-20(25-18)22(29)30)14-3-1-2-13(8-14)12-31-15-4-5-16(23-9-15)17-6-7-24-26-17/h1-9H,10-12H2,(H,24,26)(H,29,30) FBWRHTGPGDNJQF-UHFFFAOYSA-N 558411 US11365192, Example 45-42 Cytochrome P450 4F2 34.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558411&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112590 471699067 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179113 OC(=O)c1ncc2CN(Cc2n1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C23H18N6O4/c30-22(29-11-16-9-25-21(23(31)32)27-20(16)12-29)15-3-1-2-14(8-15)13-33-17-4-5-18(24-10-17)19-6-7-26-28-19/h1-10H,11-13H2,(H,26,28)(H,31,32) XRAZTMUJDXUBOD-UHFFFAOYSA-N 558412 US11365192, Example 45-43 Cytochrome P450 4F2 5200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558412&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112591 471699068 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179115 OC(=O)c1cnn2CCN(Cc12)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C23H20N6O4/c30-22(28-8-9-29-21(13-28)18(12-26-29)23(31)32)16-3-1-2-15(10-16)14-33-17-4-5-19(24-11-17)20-6-7-25-27-20/h1-7,10-12H,8-9,13-14H2,(H,25,27)(H,31,32) MTSAUIBSLGSQLN-UHFFFAOYSA-N 558413 US11365192, Example 45-44 Cytochrome P450 4F2 3500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558413&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112592 471699069 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179117 OC(=O)c1cc2CN(CCn2n1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C23H20N6O4/c30-22(28-8-9-29-17(13-28)11-21(27-29)23(31)32)16-3-1-2-15(10-16)14-33-18-4-5-19(24-12-18)20-6-7-25-26-20/h1-7,10-12H,8-9,13-14H2,(H,25,26)(H,31,32) RENNNPLLDNYQJM-UHFFFAOYSA-N 558414 US11365192, Example 45-45 Cytochrome P450 4F2 1600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558414&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112593 471699070 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179119 OC(=O)c1nc2CN(CCc2o1)C(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C23H19N5O5/c29-22(28-9-7-20-19(12-28)26-21(33-20)23(30)31)15-3-1-2-14(10-15)13-32-16-4-5-17(24-11-16)18-6-8-25-27-18/h1-6,8,10-11H,7,9,12-13H2,(H,25,27)(H,30,31) VQQRMZYIJMGQIQ-UHFFFAOYSA-N 558415 US11365192, Example 45-46 Cytochrome P450 4F2 54.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558415&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112594 471699071 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179121 Oc1cc(CNC(=O)c2cccc(COc3ccc(nc3)-c3ccn[nH]3)c2)on1 InChI=1S/C20H17N5O4/c26-19-9-16(29-25-19)11-22-20(27)14-3-1-2-13(8-14)12-28-15-4-5-17(21-10-15)18-6-7-23-24-18/h1-10H,11-12H2,(H,22,27)(H,23,24)(H,25,26) QWTUIVWBWOQUMH-UHFFFAOYSA-N 558416 US11365192, Example 45-47 Cytochrome P450 4F2 970 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558416&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112595 471699072 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179123 CC(C)(CC(=O)N1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1)C(O)=O InChI=1S/C20H26N4O4/c1-20(2,19(26)27)11-18(25)24-9-6-14(7-10-24)13-28-15-3-4-16(21-12-15)17-5-8-22-23-17/h3-5,8,12,14H,6-7,9-11,13H2,1-2H3,(H,22,23)(H,26,27) SAHWPLJZFBGIJV-UHFFFAOYSA-N 558417 2,2-Dimethyl-4-oxo-4-[4 [[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-piperidinyl]butanoic Acid::US11365192, Example 46-1 Cytochrome P450 4F2 7600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558417&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526944 471699073 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179125 CCOC(=O)c1cccc(CCCO)c1 InChI=1S/C12H16O3/c1-2-15-12(14)11-7-3-5-10(9-11)6-4-8-13/h3,5,7,9,13H,2,4,6,8H2,1H3 KDNRORPWXYEAJV-UHFFFAOYSA-N 558418 US11365192, Example 46-2 Cytochrome P450 4F2 470 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558418&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 14194902 471699074 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179127 COC(=O)c1ccc(CCCO)cc1 InChI=1S/C11H14O3/c1-14-11(13)10-6-4-9(5-7-10)3-2-8-12/h4-7,12H,2-3,8H2,1H3 ARNGRGQYXABYAT-UHFFFAOYSA-N 558419 US11365192, Example 46-3 Cytochrome P450 4F2 >50000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558419&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 14425137 471699075 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179129 COC(=O)c1cccc(CCCCO)c1 InChI=1S/C12H16O3/c1-15-12(14)11-7-4-6-10(9-11)5-2-3-8-13/h4,6-7,9,13H,2-3,5,8H2,1H3 OQGGIFWTNZJNAC-UHFFFAOYSA-N 558420 US11365192, Example 46-4 Cytochrome P450 4F2 18000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558420&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 25172820 471699076 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179131 COC(=O)c1ccc(CCCCO)cc1 InChI=1S/C12H16O3/c1-15-12(14)11-7-5-10(6-8-11)4-2-3-9-13/h5-8,13H,2-4,9H2,1H3 KVKWRSNRAXOBFC-UHFFFAOYSA-N 558421 US11365192, Example 46-5 Cytochrome P450 4F2 7500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558421&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 14603109 471699077 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179133 OC(=O)C1(CCCC(=O)N2CCC(COc3ccc(nc3)-c3ccn[nH]3)CC2)CCCC1 InChI=1S/C24H32N4O4/c29-22(4-3-12-24(23(30)31)10-1-2-11-24)28-14-8-18(9-15-28)17-32-19-5-6-20(25-16-19)21-7-13-26-27-21/h5-7,13,16,18H,1-4,8-12,14-15,17H2,(H,26,27)(H,30,31) HKQBLEVNPHSSJS-UHFFFAOYSA-N 558422 1-[4-Oxo-4-[4-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-piperidinyl]butyl]-1-cyclopentanecarboxylic Acid::US11365192, Example 47-1 Cytochrome P450 4F2 150 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558422&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526998 471699078 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179135 OC(=O)CCC(=O)N1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1 InChI=1S/C18H22N4O4/c23-17(3-4-18(24)25)22-9-6-13(7-10-22)12-26-14-1-2-15(19-11-14)16-5-8-20-21-16/h1-2,5,8,11,13H,3-4,6-7,9-10,12H2,(H,20,21)(H,24,25) GFXLVVRNIFQHPM-UHFFFAOYSA-N 558423 4-Oxo-4-[4-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-piperidinyl]butanoic Acid::US11365192, Example 48-1 Cytochrome P450 4F2 11000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558423&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526671 471699079 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179137 OC(=O)CCNC(=O)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccn1 InChI=1S/C18H17N5O4/c24-17(25)5-7-20-18(26)16-9-12(3-6-19-16)11-27-13-1-2-14(21-10-13)15-4-8-22-23-15/h1-4,6,8-10H,5,7,11H2,(H,20,26)(H,22,23)(H,24,25) RPFQIDZACMAQFN-UHFFFAOYSA-N 558424 3-[[Oxo-[4-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-2-pyridinyl]methyl]amino]propanoic Acid::US11365192, Example 49-1 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558424&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526688 471699080 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179139 OC(=O)C1(CCCC1)NC(=O)CCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C21H28N4O4/c26-19(24-21(20(27)28)11-4-5-12-21)7-3-1-2-6-14-29-16-8-9-17(22-15-16)18-10-13-23-25-18/h8-10,13,15H,1-7,11-12,14H2,(H,23,25)(H,24,26)(H,27,28) CPPDZKOBPSDWNF-UHFFFAOYSA-N 558425 1-[[1-Oxo-7-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]heptyl]amino]-1-cyclopentanecarboxylic Acid::US11365192, Example 50-1 Cytochrome P450 4F2 2800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558425&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526872 471699081 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179141 COC(=O)N1CCC(O)(CC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H24N4O4/c1-29-21(27)26-11-8-22(28,9-12-26)17-4-2-3-16(13-17)15-30-18-5-6-19(23-14-18)20-7-10-24-25-20/h2-7,10,13-14,28H,8-9,11-12,15H2,1H3,(H,24,25) BXUQAAWNBRFZBX-UHFFFAOYSA-N 558426 Methyl 4-hydroxy-4-[3-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-piperidinecarboxylate::US11365192, Example 51-1 Cytochrome P450 4F2 3.00 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558426&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658393 471699082 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179143 CCOC(=O)C(C)(C)n1ccc(CCCCO)n1 InChI=1S/C13H22N2O3/c1-4-18-12(17)13(2,3)15-9-8-11(14-15)7-5-6-10-16/h8-9,16H,4-7,10H2,1-3H3 QALSMOZYODALNB-UHFFFAOYSA-N 558427 US11365192, Example 51-2 Cytochrome P450 4F2 3.50 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558427&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323835 471699083 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179145 CC(=O)N1CCC(O)(CC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H24N4O3/c1-16(27)26-11-8-22(28,9-12-26)18-4-2-3-17(13-18)15-29-19-5-6-20(23-14-19)21-7-10-24-25-21/h2-7,10,13-14,28H,8-9,11-12,15H2,1H3,(H,24,25) GLAJBEWXPBLBND-UHFFFAOYSA-N 558428 1-[4-Hydroxy-4-[3-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-piperidinyl]ethanone::US11365192, Example 52-1 Cytochrome P450 4F2 4.40 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558428&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147659267 471699084 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179147 CC(=O)N1CC(O)(C1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H20N4O3/c1-14(25)24-12-20(26,13-24)16-4-2-3-15(9-16)11-27-17-5-6-18(21-10-17)19-7-8-22-23-19/h2-10,26H,11-13H2,1H3,(H,22,23) IRXCERHYDIJWKG-UHFFFAOYSA-N 558429 US11365192, Example 52-2 Cytochrome P450 4F2 50.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558429&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112596 471699085 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179149 NC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C16H14N4O2/c17-16(21)12-3-1-2-11(8-12)10-22-13-4-5-14(18-9-13)15-6-7-19-20-15/h1-9H,10H2,(H2,17,21)(H,19,20) JDVRNQHRXFPJQJ-UHFFFAOYSA-N 558430 3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]benzamide::US11365192, Example 53-1 Cytochrome P450 4F2 190 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558430&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487711 471699086 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179151 NC(=O)c1cc(COc2ccc(nc2)-c2n[nH]cc2Cl)ccn1 InChI=1S/C15H12ClN5O2/c16-11-7-20-21-14(11)12-2-1-10(6-19-12)23-8-9-3-4-18-13(5-9)15(17)22/h1-7H,8H2,(H2,17,22)(H,20,21) RLYKEIFEAASKRB-UHFFFAOYSA-N 558431 US11365192, Example 53-2 Cytochrome P450 4F2 16.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558431&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112597 471699087 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179153 CS(=O)(=O)NC(=O)CCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C15H20N4O4S/c1-24(21,22)19-15(20)5-3-2-4-10-23-12-6-7-13(16-11-12)14-8-9-17-18-14/h6-9,11H,2-5,10H2,1H3,(H,17,18)(H,19,20) LZTOHBSBXFTRNO-UHFFFAOYSA-N 558432 N-Methylsulfonyl-6-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]hexanamide::US11365192, Example 54-1 Cytochrome P450 4F2 21000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558432&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526724 471699088 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179155 CC(C)(CCNC(=O)N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1)C(O)=O 558433 2,2-Dimethyl-4-[[oxo-[(3R)-3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-piperidinyl]methyl] amino]butanoic Acid::US11365192, Example 55-1 Cytochrome P450 4F2 6500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558433&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526859 471699089 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179157 CC(C)S(=O)(=O)Nc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H20N4O3S/c1-13(2)26(23,24)22-15-5-3-4-14(10-15)12-25-16-6-7-17(19-11-16)18-8-9-20-21-18/h3-11,13,22H,12H2,1-2H3,(H,20,21) ARAVXHXKHQVKBV-UHFFFAOYSA-N 558434 N-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-2-propanesulfonamide::US11365192, Example 56-1 Cytochrome P450 4F2 450 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558434&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526692 471699090 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179159 Cc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1OS(C)(=O)=O InChI=1S/C17H17N3O4S/c1-12-3-4-13(9-17(12)24-25(2,21)22)11-23-14-5-6-15(18-10-14)16-7-8-19-20-16/h3-10H,11H2,1-2H3,(H,19,20) PSEARXPODZQMKT-UHFFFAOYSA-N 558435 US11365192, Example 57-1::[2-Methyl-5-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]methanesulfonate Cytochrome P450 4F2 140 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558435&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526520 471699091 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179161 CS(=O)(=O)N[C@H]1CC[C@H](CC1)Oc1ccc(nc1)-c1ccn[nH]1 558436 US11365192, Example 57-2 Cytochrome P450 4F2 7300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558436&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112598 471699092 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179163 CN([C@H]1CC[C@@H](CC1)Oc1ccc(nc1)-c1ccn[nH]1)S(C)(=O)=O 558437 US11365192, Example 57-3 Cytochrome P450 4F2 2000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558437&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112599 471699093 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179165 CS(=O)(=O)NCC12CC(COc3ccc(nc3)-c3ccn[nH]3)(C1)C2 InChI=1S/C16H20N4O3S/c1-24(21,22)19-10-15-7-16(8-15,9-15)11-23-12-2-3-13(17-6-12)14-4-5-18-20-14/h2-6,19H,7-11H2,1H3,(H,18,20) SXJZOGMBKSGOFM-UHFFFAOYSA-N 558438 N-[[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-bicyclo[1.1.1]pentanyl]methyl]methanesulfonamide::US11365192, Example 58-1 Cytochrome P450 4F2 120 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558438&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526807 471699094 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179167 CN(CC12CC(COc3ccc(nc3)-c3ccn[nH]3)(C1)C2)S(C)(=O)=O InChI=1S/C17H22N4O3S/c1-21(25(2,22)23)11-16-8-17(9-16,10-16)12-24-13-3-4-14(18-7-13)15-5-6-19-20-15/h3-7H,8-12H2,1-2H3,(H,19,20) ZIADXPUZMKQYCZ-UHFFFAOYSA-N 558439 N-Methyl-N-[[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-bicyclo[1.1.1]pentanyl]methyl]methanesulfonamide::US11365192, Example 58-2 Cytochrome P450 4F2 5.10 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558439&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526776 471699095 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179169 OC(Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(F)(F)F 558440 1,1,1-Trifluoro-3-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-2-propanol::US11365192, Example 59-1 Cytochrome P450 4F2 10.00 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558440&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526587 471699096 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179171 OC(Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(F)F 558441 2,2-Difluoro-1-[4-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]ethanol::US11365192, Example 59-2 Cytochrome P450 4F2 100.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558441&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323988 471699097 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179173 OC(c1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1)C(F)(F)F 558442 US11365192, Example 59-3 Cytochrome P450 4F2 41.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558442&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112600 471699098 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179175 OC(=O)C(F)(F)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H13F2N3O3/c18-17(19,16(23)24)12-3-1-2-11(8-12)10-25-13-4-5-14(20-9-13)15-6-7-21-22-15/h1-9H,10H2,(H,21,22)(H,23,24) SVUIMVPDOYTVFT-UHFFFAOYSA-N 558443 2,2-Difluoro-2-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]acetic Acid::US11365192, Example 60-1 Cytochrome P450 4F2 37000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558443&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526982 471699099 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179177 CCOC(=O)C1CCc2cc(CO)ccc2O1 InChI=1S/C13H16O4/c1-2-16-13(15)12-6-4-10-7-9(8-14)3-5-11(10)17-12/h3,5,7,12,14H,2,4,6,8H2,1H3 FCVWGSYDEBAWSU-UHFFFAOYSA-N 558444 2,2-Difluoro-2-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]ethanol::US11365192, Example 60-2 Cytochrome P450 4F2 130 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558444&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147476858 471699100 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179179 CS(=O)(=O)NC(=O)NCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C14H19N5O4S/c1-24(21,22)19-14(20)15-7-2-3-9-23-11-4-5-12(16-10-11)13-6-8-17-18-13/h4-6,8,10H,2-3,7,9H2,1H3,(H,17,18)(H2,15,19,20) OJPMOSCPZBOAGY-UHFFFAOYSA-N 558445 1-Methylsulfonyl-3-[4-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxy]butyl]urea::US11365192, Example 61-1 Cytochrome P450 4F2 8000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558445&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658451 471699101 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179181 O=C1CN(CCCCOc2ccc(nc2)-c2ccn[nH]2)C(=O)N1 InChI=1S/C15H17N5O3/c21-14-10-20(15(22)18-14)7-1-2-8-23-11-3-4-12(16-9-11)13-5-6-17-19-13/h3-6,9H,1-2,7-8,10H2,(H,17,19)(H,18,21,22) PJECQYXZOKGSSX-UHFFFAOYSA-N 558446 1-[4-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxy]butyl]imidazolidine-2,4-dione::US11365192, Example 61-2 Cytochrome P450 4F2 280 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558446&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658375 471699102 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179183 C(CCOc1ccc(nc1)-c1ccn[nH]1)CCc1nnn[nH]1 InChI=1S/C14H17N7O/c1(2-4-14-18-20-21-19-14)3-9-22-11-5-6-12(15-10-11)13-7-8-16-17-13/h5-8,10H,1-4,9H2,(H,16,17)(H,18,19,20,21) FMSBRXPKXOKSIE-UHFFFAOYSA-N 558447 2-(1H-Pyrazol-5-yl)-5-[5-(1H-tetrazol-5-yl)pentoxy]pyridine::US11365192, Example 62-1 Cytochrome P450 4F2 3500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558447&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526706 471699103 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179185 O=c1[nH]c(CCCCCOc2ccc(nc2)-c2ccn[nH]2)no1 InChI=1S/C15H17N5O3/c21-15-18-14(20-23-15)4-2-1-3-9-22-11-5-6-12(16-10-11)13-7-8-17-19-13/h5-8,10H,1-4,9H2,(H,17,19)(H,18,20,21) PGSGHDPSXWQLHW-UHFFFAOYSA-N 558448 3-[5-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]pentyl]-4H-1,2,4-oxadiazol-5-one::US11365192, Example 62-2 Cytochrome P450 4F2 1900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558448&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112601 471699104 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179187 O=C1NC(=O)C(CCCCOc2ccc(nc2)-c2ccn[nH]2)O1 558449 5-[4-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]butyl]oxazolidine-2,4-dione::US11365192, Example 63-1 Cytochrome P450 4F2 12000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558449&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526819 471699105 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179189 Oc1cc(CCCCOc2ccc(nc2)-c2ccn[nH]2)on1 InChI=1S/C15H16N4O3/c20-15-9-11(22-19-15)3-1-2-8-21-12-4-5-13(16-10-12)14-6-7-17-18-14/h4-7,9-10H,1-3,8H2,(H,17,18)(H,19,20) MMPIAAFEWHRVKA-UHFFFAOYSA-N 558450 5-[4-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]butyl]-3-isoxazole::US11365192, Example 64-1 Cytochrome P450 4F2 780 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558450&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487707 471699106 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179191 FC(F)(F)S(=O)(=O)NCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H15F3N4O3S/c18-17(19,20)28(25,26)23-9-12-2-1-3-13(8-12)11-27-14-4-5-15(21-10-14)16-6-7-22-24-16/h1-8,10,23H,9,11H2,(H,22,24) UGSXJELFSTWWLK-UHFFFAOYSA-N 558451 1,1,1-Trifluoro-N-[[3-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]methyl]methanesulfonamide::US11365192, Example 65-1 Cytochrome P450 4F2 63.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558451&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112602 471699107 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179193 CS(=O)(=O)c1cc(O)cc(COc2ccc(nc2)-c2[nH]ncc2Cl)c1 InChI=1S/C16H14ClN3O4S/c1-25(22,23)13-5-10(4-11(21)6-13)9-24-12-2-3-15(18-7-12)16-14(17)8-19-20-16/h2-8,21H,9H2,1H3,(H,19,20) CYJCMKSVIZOTHB-UHFFFAOYSA-N 558452 3-[[6-(4-Chloro-1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-5-methylsulfonylphenol::US11365192, Example 66-1 Cytochrome P450 4F2 16.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558452&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142527050 471699108 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179195 NC(=O)c1cc(COc2ccc(nc2)-c2[nH]ncc2C(F)F)ccn1 InChI=1S/C16H13F2N5O2/c17-15(18)11-7-22-23-14(11)12-2-1-10(6-21-12)25-8-9-3-4-20-13(5-9)16(19)24/h1-7,15H,8H2,(H2,19,24)(H,22,23) RJOHXJHWCNMIRQ-UHFFFAOYSA-N 558453 4-[[6-[4-(Difluoromethyl)-1H-pyrazol-5-yl]-3-pyridinyl]oxymethyl]-2-pyridinecarboxamide::US11365192, Example 67-1 Cytochrome P450 4F2 2700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558453&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112603 471699109 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179197 OC(=O)C1(CCOCC1)OCCCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C22H31N3O5/c26-21(27)22(10-15-28-16-11-22)30-14-6-4-2-1-3-5-13-29-18-7-8-19(23-17-18)20-9-12-24-25-20/h7-9,12,17H,1-6,10-11,13-16H2,(H,24,25)(H,26,27) OCRXHKLDJMHANM-UHFFFAOYSA-N 558454 4-[8-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]octoxy]-4-oxanecarboxylic Acid::US11365192, Example 68-1 Cytochrome P450 4F2 39.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558454&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526980 471699110 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179199 OC(=O)[C@@H]1CCc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2C1 558455 US11365192, Example 69-1-1 Cytochrome P450 4F2 240 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558455&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112604 471699111 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179201 OC(=O)[C@H]1CCc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2C1 558456 US11365192, Example 69-1-2 Cytochrome P450 4F2 200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558456&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112605 471699112 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179203 OC(=O)[C@@H]1COc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2C1 558457 US11365192, Example 69-2-1 Cytochrome P450 4F2 600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558457&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112606 471699113 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179205 OC(=O)[C@H]1COc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2C1 558458 US11365192, Example 69-2-2 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558458&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112607 471699114 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179207 OC(=O)[C@@H]1CCc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2O1 558459 US11365192, Example 69-3-1 Cytochrome P450 4F2 110 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558459&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112608 471699115 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179209 OC(=O)[C@H]1CCc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2O1 558460 US11365192, Example 69-3-2 Cytochrome P450 4F2 300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558460&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112609 471699116 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179211 OC(=O)[C@@H]1CCCN(C1)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558461 US11365192, Example 69-4-1 Cytochrome P450 4F2 86.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558461&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112610 471699117 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179213 OC(=O)[C@H]1CCCN(C1)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558462 US11365192, Example 69-4-2 Cytochrome P450 4F2 670 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558462&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658405 471699118 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179215 OC(=O)\C=C\c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1F InChI=1S/C18H14FN3O3/c19-18-12(4-7-17(23)24)2-1-3-13(18)11-25-14-5-6-15(20-10-14)16-8-9-21-22-16/h1-10H,11H2,(H,21,22)(H,23,24)/b7-4+ JQXVUSYFSKLKEA-QPJJXVBHSA-N 558463 (E)-3-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxymethyl]phenyl]prop-2-enoic Acid::US11365192, Example 70-1 Cytochrome P450 4F2 49.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558463&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526774 471699119 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179217 OC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1F InChI=1S/C18H16FN3O3/c19-18-12(4-7-17(23)24)2-1-3-13(18)11-25-14-5-6-15(20-10-14)16-8-9-21-22-16/h1-3,5-6,8-10H,4,7,11H2,(H,21,22)(H,23,24) CZMOXSHKMUQVFQ-UHFFFAOYSA-N 558464 3-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxymethyl]phenyl]propanoic Acid::US11365192, Example 70-2 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558464&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487714 471699120 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179219 OC(=O)C1CC1c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1F 558465 2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxymethyl]phenyl]cyclopropane-1-carboxylic Acid::US11365192, Example 70-3::US11365192, Example 71-45::US11365192, Example 71-46 Cytochrome P450 4F2 280 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558465&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526822 471699121 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179221 OC(=O)\C=C\c1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H17N3O3/c23-19(24)7-4-14-2-1-3-15(12-14)9-11-25-16-5-6-17(20-13-16)18-8-10-21-22-18/h1-8,10,12-13H,9,11H2,(H,21,22)(H,23,24)/b7-4+ FIBZCQBEHNEJLR-QPJJXVBHSA-N 558466 US11365192, Example 70-4 Cytochrome P450 4F2 56.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558466&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112611 471699122 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179223 OC(=O)\C=C\c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1F InChI=1S/C19H16FN3O3/c20-16-11-13(1-2-14(16)3-6-19(24)25)8-10-26-15-4-5-17(21-12-15)18-7-9-22-23-18/h1-7,9,11-12H,8,10H2,(H,22,23)(H,24,25)/b6-3+ KKLLSGBPCOLTKM-ZZXKWVIFSA-N 558467 US11365192, Example 70-5 Cytochrome P450 4F2 27.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558467&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112612 471699123 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179225 OC(=O)\C=C\c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C19H17N3O3/c23-19(24)8-5-14-1-3-15(4-2-14)10-12-25-16-6-7-17(20-13-16)18-9-11-21-22-18/h1-9,11,13H,10,12H2,(H,21,22)(H,23,24)/b8-5+ QFRNJFPRGYDZMR-VMPITWQZSA-N 558468 US11365192, Example 70-6 Cytochrome P450 4F2 47.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558468&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112613 471699124 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179227 OC(=O)C1CC1c1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 558469 US11365192, Example 70-7 Cytochrome P450 4F2 320 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558469&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147867226 471699125 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179229 OC(=O)C1CC1c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1F 558470 US11365192, Example 70-8 Cytochrome P450 4F2 120 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558470&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323997 471699126 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179231 OC(=O)C1CC1c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1 558471 US11365192, Example 70-9 Cytochrome P450 4F2 200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558471&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 153012712 471699127 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179233 OC(=O)[C@@H]1C[C@@H]1c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1 558472 US11365192, Example 70-10-1 Cytochrome P450 4F2 120 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558472&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112614 471699128 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179235 OC(=O)[C@H]1C[C@@H]1c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1 558473 US11365192, Example 70-10-2 Cytochrome P450 4F2 340 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558473&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112615 471699129 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179237 OC(=O)C1CC1c1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1F 558474 2-[2-Fluoro-4-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxymethyl]phenyl]cyclopropane-1-carboxylic Acid::US11365192, Example 70-11 Cytochrome P450 4F2 330 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558474&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142527051 471699130 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179239 CCC(OCCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O 558475 2-[7-[6-(1H-Pyrazol-5-yl)pyridin-3-yl]oxyheptoxy]butanoic Acid::US11365192, Example 71-1 Cytochrome P450 4F2 140 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558475&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526781 471699131 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179241 CC[C@@H](OCCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O 558476 US11365192, Example 71-2-1 Cytochrome P450 4F2 300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558476&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112616 471699132 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179243 CC[C@H](OCCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O 558477 US11365192, Example 71-2-2 Cytochrome P450 4F2 90.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558477&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112617 471699133 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179245 OC(=O)COCCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C17H23N3O4/c21-17(22)13-23-10-4-2-1-3-5-11-24-14-6-7-15(18-12-14)16-8-9-19-20-16/h6-9,12H,1-5,10-11,13H2,(H,19,20)(H,21,22) JBANYXPIXMBJDE-UHFFFAOYSA-N 558478 US11365192, Example 71-3 Cytochrome P450 4F2 320 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558478&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323999 471699134 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179247 CC(OCCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O 558479 US11365192, Example 71-4 Cytochrome P450 4F2 200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558479&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324040 471699135 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179249 OC(=O)C1(CC1)OCCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C19H25N3O4/c23-18(24)19(9-10-19)26-13-5-3-1-2-4-12-25-15-6-7-16(20-14-15)17-8-11-21-22-17/h6-8,11,14H,1-5,9-10,12-13H2,(H,21,22)(H,23,24) LGQOGWNRJBBXIN-UHFFFAOYSA-N 558480 US11365192, Example 71-5 Cytochrome P450 4F2 39.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558480&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324059 471699136 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179251 OC(=O)C1(COC1)OCCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C19H25N3O5/c23-18(24)19(13-25-14-19)27-11-5-3-1-2-4-10-26-15-6-7-16(20-12-15)17-8-9-21-22-17/h6-9,12H,1-5,10-11,13-14H2,(H,21,22)(H,23,24) GSTVVHPCTJGBOE-UHFFFAOYSA-N 558481 US11365192, Example 71-6 Cytochrome P450 4F2 100.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558481&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 154931386 471699137 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179253 OC(=O)C1CCc2cc(CCOc3ccc(nc3)-c3ccn[nH]3)ccc2O1 558482 6-[2-[6-(1H-Pyrazol-5-yl)pyridin-3-yl]oxyethyl]-3,4-dihydro-2H-chromene-2-carboxylic Acid::US11365192, Example 71-7 Cytochrome P450 4F2 550 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558482&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526809 471699138 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179255 OC(=O)[C@@H]1CCc2cc(CCOc3ccc(nc3)-c3ccn[nH]3)ccc2O1 558483 US11365192, Example 71-8-1 Cytochrome P450 4F2 430 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558483&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112618 471699139 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179257 OC(=O)[C@H]1CCc2cc(CCOc3ccc(nc3)-c3ccn[nH]3)ccc2O1 558484 US11365192, Example 71-8-2 Cytochrome P450 4F2 560 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558484&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112619 471699140 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179259 OC(=O)C1COc2cc(CCOc3ccc(nc3)-c3ccn[nH]3)ccc2C1 558485 US11365192, Example 71-9 Cytochrome P450 4F2 870 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558485&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149384617 471699141 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179261 OC(=O)C1COc2ccc(CCOc3ccc(nc3)-c3ccn[nH]3)cc2C1 558486 US11365192, Example 71-10 Cytochrome P450 4F2 260 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558486&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324010 471699142 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179263 OC(=O)C1CCc2c(COc3ccc(nc3)-c3ccn[nH]3)cccc2O1 558487 US11365192, Example 71-11 Cytochrome P450 4F2 29000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558487&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324044 471699143 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179265 OC(=O)C1COc2c(CCOc3ccc(nc3)-c3ccn[nH]3)cccc2C1 558488 US11365192, Example 71-12 Cytochrome P450 4F2 1300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558488&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147840582 471699144 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179267 OC(=O)c1ccc(F)c(CCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H16FN3O3/c19-15-5-3-13(18(23)24)10-12(15)2-1-9-25-14-4-6-16(20-11-14)17-7-8-21-22-17/h3-8,10-11H,1-2,9H2,(H,21,22)(H,23,24) HDVACUOCXAWPJW-UHFFFAOYSA-N 558489 US11365192, Example 71-13 Cytochrome P450 4F2 770 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558489&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323926 471699145 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179269 OC(=O)c1cccc(CCCCCOc2ccc(nc2)-c2ccn[nH]2)n1 InChI=1S/C19H20N4O3/c24-19(25)18-7-4-6-14(22-18)5-2-1-3-12-26-15-8-9-16(20-13-15)17-10-11-21-23-17/h4,6-11,13H,1-3,5,12H2,(H,21,23)(H,24,25) RFINJSDXXVAHKV-UHFFFAOYSA-N 558490 US11365192, Example 71-14 Cytochrome P450 4F2 1300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558490&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324018 471699146 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179271 OC(=O)C1CC1c1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1 558491 US11365192, Example 71-15 Cytochrome P450 4F2 1200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558491&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323905 471699147 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179273 OC(=O)C1CC1c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)c(F)c1 558492 US11365192, Example 71-16::US11365192, Example 71-17::US11365192, Example 71-18 Cytochrome P450 4F2 91.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558492&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148253389 471699148 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179275 OC(=O)C1CC1c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)c(F)c1 558492 US11365192, Example 71-16::US11365192, Example 71-17::US11365192, Example 71-18 Cytochrome P450 4F2 520 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558492&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148253389 471699148 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179277 OC(=O)C1CC1c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)c(F)c1 558492 US11365192, Example 71-16::US11365192, Example 71-17::US11365192, Example 71-18 Cytochrome P450 4F2 83.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558492&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148253389 471699148 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179279 OC(=O)C1CC(C1)c1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H21N3O3/c25-21(26)17-11-16(12-17)15-3-1-2-14(10-15)7-9-27-18-4-5-19(22-13-18)20-6-8-23-24-20/h1-6,8,10,13,16-17H,7,9,11-12H2,(H,23,24)(H,25,26) XLJAUYOGTCWPRC-UHFFFAOYSA-N 558495 US11365192, Example 71-19 Cytochrome P450 4F2 540 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558495&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112620 471699149 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179281 OC(=O)C1CC(C1)c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C21H21N3O3/c25-21(26)17-11-16(12-17)15-3-1-14(2-4-15)8-10-27-18-5-6-19(22-13-18)20-7-9-23-24-20/h1-7,9,13,16-17H,8,10-12H2,(H,23,24)(H,25,26) QVRMXVLCSQBCBR-UHFFFAOYSA-N 558496 US11365192, Example 71-20 Cytochrome P450 4F2 190 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558496&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112621 471699150 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179283 OC(=O)C1CCc2ccc(CCOc3ccc(nc3)-c3ccn[nH]3)cc2O1 558497 7-[2-[6-(1H-Pyrazol-5-yl)pyridin-3-yl]oxyethyl]-3,4-dihydro-2H-chromene-2-carboxylic Acid::US11365192, Example 71-21 Cytochrome P450 4F2 190 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558497&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142527043 471699151 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179285 OC(=O)[C@H]1CCc2ccc(CCOc3ccc(nc3)-c3ccn[nH]3)cc2O1 558498 US11365192, Example 71-22-1 Cytochrome P450 4F2 310 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558498&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112622 471699152 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179287 OC(=O)[C@@H]1CCc2ccc(CCOc3ccc(nc3)-c3ccn[nH]3)cc2O1 558499 US11365192, Example 71-22-2 Cytochrome P450 4F2 160 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558499&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112623 471699153 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179289 OC(=O)C1COc2cc(COc3ccc(nc3)-c3ccn[nH]3)ccc2C1 558500 US11365192, Example 71-23 Cytochrome P450 4F2 550 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558500&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324001 471699154 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179291 OC(=O)C1CC1c1ccc(COc2ccc(nc2)-c2ccn[nH]2)c(F)c1 558501 US11365192, Example 71-24 Cytochrome P450 4F2 2100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558501&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112624 471699155 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179293 CC(C)(Cc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1)C(O)=O InChI=1S/C20H21N3O3/c1-20(2,19(24)25)11-14-3-5-15(6-4-14)13-26-16-7-8-17(21-12-16)18-9-10-22-23-18/h3-10,12H,11,13H2,1-2H3,(H,22,23)(H,24,25) KEIYOMKQJYYKBS-UHFFFAOYSA-N 558502 US11365192, Example 71-25 Cytochrome P450 4F2 4800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558502&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112625 471699156 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179295 OC(=O)C1(Cc2cccc(COc3ccc(nc3)-c3ccn[nH]3)c2F)COC1 InChI=1S/C20H18FN3O4/c21-18-13(8-20(19(25)26)11-27-12-20)2-1-3-14(18)10-28-15-4-5-16(22-9-15)17-6-7-23-24-17/h1-7,9H,8,10-12H2,(H,23,24)(H,25,26) XOKOCTRSAXQDHS-UHFFFAOYSA-N 558503 US11365192, Example 71-26 Cytochrome P450 4F2 9700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558503&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112626 471699157 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179297 OC(=O)C1(Cc2cccc(CCOc3ccc(nc3)-c3ccn[nH]3)c2F)COC1 InChI=1S/C21H20FN3O4/c22-19-14(2-1-3-15(19)10-21(20(26)27)12-28-13-21)7-9-29-16-4-5-17(23-11-16)18-6-8-24-25-18/h1-6,8,11H,7,9-10,12-13H2,(H,24,25)(H,26,27) ZUAIIBRLGWGLTH-UHFFFAOYSA-N 558504 US11365192, Example 71-27 Cytochrome P450 4F2 15000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558504&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112627 471699158 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179299 CC(C)(Cc1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cn1)C(O)=O InChI=1S/C20H22N4O3/c1-20(2,19(25)26)11-15-4-3-14(12-21-15)8-10-27-16-5-6-17(22-13-16)18-7-9-23-24-18/h3-7,9,12-13H,8,10-11H2,1-2H3,(H,23,24)(H,25,26) RJVUKCAUSWMMPW-UHFFFAOYSA-N 558505 US11365192, Example 71-28 Cytochrome P450 4F2 6200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558505&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323936 471699159 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179301 OC(=O)c1ccc(CCCCCOc2ccc(nc2)-c2ccn[nH]2)cn1 InChI=1S/C19H20N4O3/c24-19(25)18-7-5-14(12-20-18)4-2-1-3-11-26-15-6-8-16(21-13-15)17-9-10-22-23-17/h5-10,12-13H,1-4,11H2,(H,22,23)(H,24,25) HNZWPAFIZNEVER-UHFFFAOYSA-N 558506 US11365192, Example 71-29 Cytochrome P450 4F2 260 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558506&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323923 471699160 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179303 CC(C)(Oc1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1)C(O)=O InChI=1S/C20H21N3O4/c1-20(2,19(24)25)27-15-5-3-14(4-6-15)10-12-26-16-7-8-17(21-13-16)18-9-11-22-23-18/h3-9,11,13H,10,12H2,1-2H3,(H,22,23)(H,24,25) YGEBRRSBMKTJTJ-UHFFFAOYSA-N 558507 US11365192, Example 71-30 Cytochrome P450 4F2 11000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558507&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149351803 471699161 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179305 CC(C)(Oc1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C20H21N3O4/c1-20(2,19(24)25)27-15-5-3-4-14(12-15)9-11-26-16-6-7-17(21-13-16)18-8-10-22-23-18/h3-8,10,12-13H,9,11H2,1-2H3,(H,22,23)(H,24,25) DOOKEUGHDVGLHD-UHFFFAOYSA-N 558508 US11365192, Example 71-31 Cytochrome P450 4F2 15000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558508&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324108 471699162 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179307 CC(C)(Oc1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cn1)C(O)=O InChI=1S/C19H20N4O4/c1-19(2,18(24)25)27-17-6-3-13(11-21-17)8-10-26-14-4-5-15(20-12-14)16-7-9-22-23-16/h3-7,9,11-12H,8,10H2,1-2H3,(H,22,23)(H,24,25) IIELDOIGOVLENT-UHFFFAOYSA-N 558509 US11365192, Example 71-32 Cytochrome P450 4F2 23000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558509&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324065 471699163 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179309 CC(C)(COc1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cn1)C(O)=O InChI=1S/C20H22N4O4/c1-20(2,19(25)26)13-28-18-6-3-14(11-22-18)8-10-27-15-4-5-16(21-12-15)17-7-9-23-24-17/h3-7,9,11-12H,8,10,13H2,1-2H3,(H,23,24)(H,25,26) XRSCGYZHEXGTRT-UHFFFAOYSA-N 558510 US11365192, Example 71-33 Cytochrome P450 4F2 600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558510&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324015 471699164 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179311 CC(C)(Oc1cc(CCOc2ccc(nc2)-c2ccn[nH]2)ccn1)C(O)=O InChI=1S/C19H20N4O4/c1-19(2,18(24)25)27-17-11-13(5-8-20-17)7-10-26-14-3-4-15(21-12-14)16-6-9-22-23-16/h3-6,8-9,11-12H,7,10H2,1-2H3,(H,22,23)(H,24,25) XEETVBVHCQJPJH-UHFFFAOYSA-N 558511 US11365192, Example 71-34 Cytochrome P450 4F2 36000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558511&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324017 471699165 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179313 CC(C)(COc1cc(CCOc2ccc(nc2)-c2ccn[nH]2)ccn1)C(O)=O InChI=1S/C20H22N4O4/c1-20(2,19(25)26)13-28-18-11-14(5-8-21-18)7-10-27-15-3-4-16(22-12-15)17-6-9-23-24-17/h3-6,8-9,11-12H,7,10,13H2,1-2H3,(H,23,24)(H,25,26) RIEZFFBVHIJSFV-UHFFFAOYSA-N 558512 US11365192, Example 71-35 Cytochrome P450 4F2 1900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558512&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324064 471699166 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179315 CC(C)(Oc1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)n1)C(O)=O InChI=1S/C19H20N4O4/c1-19(2,18(24)25)27-17-5-3-4-13(22-17)9-11-26-14-6-7-15(20-12-14)16-8-10-21-23-16/h3-8,10,12H,9,11H2,1-2H3,(H,21,23)(H,24,25) LZIGVAFQFUWCHN-UHFFFAOYSA-N 558513 US11365192, Example 71-36 Cytochrome P450 4F2 >50000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558513&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324084 471699167 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179317 CC(C)(COc1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)n1)C(O)=O InChI=1S/C20H22N4O4/c1-20(2,19(25)26)13-28-18-5-3-4-14(23-18)9-11-27-15-6-7-16(21-12-15)17-8-10-22-24-17/h3-8,10,12H,9,11,13H2,1-2H3,(H,22,24)(H,25,26) ICUCBYJFZKJEOL-UHFFFAOYSA-N 558514 US11365192, Example 71-37 Cytochrome P450 4F2 3500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558514&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323976 471699168 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179319 CC(C)(Oc1ccc(CCCOc2ccc(nc2)-c2ccn[nH]2)cn1)C(O)=O InChI=1S/C20H22N4O4/c1-20(2,19(25)26)28-18-8-5-14(12-22-18)4-3-11-27-15-6-7-16(21-13-15)17-9-10-23-24-17/h5-10,12-13H,3-4,11H2,1-2H3,(H,23,24)(H,25,26) CAJYVGMMQIBCJY-UHFFFAOYSA-N 558515 US11365192, Example 71-38 Cytochrome P450 4F2 1900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558515&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324016 471699169 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179321 CC(C)(COc1ccc(CCCOc2ccc(nc2)-c2ccn[nH]2)cn1)C(O)=O InChI=1S/C21H24N4O4/c1-21(2,20(26)27)14-29-19-8-5-15(12-23-19)4-3-11-28-16-6-7-17(22-13-16)18-9-10-24-25-18/h5-10,12-13H,3-4,11,14H2,1-2H3,(H,24,25)(H,26,27) LWMCLGNVPQCOSQ-UHFFFAOYSA-N 558516 US11365192, Example 71-39 Cytochrome P450 4F2 51.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558516&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323918 471699170 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179323 CC(C)(Oc1cccc(CCCOc2ccc(nc2)-c2ccn[nH]2)n1)C(O)=O InChI=1S/C20H22N4O4/c1-20(2,19(25)26)28-18-7-3-5-14(23-18)6-4-12-27-15-8-9-16(21-13-15)17-10-11-22-24-17/h3,5,7-11,13H,4,6,12H2,1-2H3,(H,22,24)(H,25,26) ZKYVHMMNCJXHMN-UHFFFAOYSA-N 558517 US11365192, Example 71-40 Cytochrome P450 4F2 8700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558517&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324025 471699171 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179325 CC(C)(COc1cccc(CCCOc2ccc(nc2)-c2ccn[nH]2)n1)C(O)=O InChI=1S/C21H24N4O4/c1-21(2,20(26)27)14-29-19-7-3-5-15(24-19)6-4-12-28-16-8-9-17(22-13-16)18-10-11-23-25-18/h3,5,7-11,13H,4,6,12,14H2,1-2H3,(H,23,25)(H,26,27) DJLAIEZCJKUQFT-UHFFFAOYSA-N 558518 US11365192, Example 71-41 Cytochrome P450 4F2 660 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558518&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324012 471699172 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179327 CC(C)(Oc1cc(CCCOc2ccc(nc2)-c2ccn[nH]2)ccn1)C(O)=O InChI=1S/C20H22N4O4/c1-20(2,19(25)26)28-18-12-14(7-9-21-18)4-3-11-27-15-5-6-16(22-13-15)17-8-10-23-24-17/h5-10,12-13H,3-4,11H2,1-2H3,(H,23,24)(H,25,26) CJLIIOXGTJDYBK-UHFFFAOYSA-N 558519 US11365192, Example 71-42 Cytochrome P450 4F2 2100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558519&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323977 471699173 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179329 CC(C)(COc1cc(CCCOc2ccc(nc2)-c2ccn[nH]2)ccn1)C(O)=O InChI=1S/C21H24N4O4/c1-21(2,20(26)27)14-29-19-12-15(7-9-22-19)4-3-11-28-16-5-6-17(23-13-16)18-8-10-24-25-18/h5-10,12-13H,3-4,11,14H2,1-2H3,(H,24,25)(H,26,27) YGKDHPILOUXCDU-UHFFFAOYSA-N 558520 US11365192, Example 71-43 Cytochrome P450 4F2 250 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558520&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324049 471699174 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179331 CC(=O)N1CC(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)(C1)C(O)=O InChI=1S/C22H30N4O4/c1-17(27)26-15-22(16-26,21(28)29)11-6-4-2-3-5-7-13-30-18-8-9-19(23-14-18)20-10-12-24-25-20/h8-10,12,14H,2-7,11,13,15-16H2,1H3,(H,24,25)(H,28,29) QVPFIDYFHFNGFU-UHFFFAOYSA-N 558521 US11365192, Example 71-44 Cytochrome P450 4F2 37.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558521&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323958 471699175 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179333 OC(=O)C1CC1c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1F 558465 2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxymethyl]phenyl]cyclopropane-1-carboxylic Acid::US11365192, Example 70-3::US11365192, Example 71-45::US11365192, Example 71-46 Cytochrome P450 4F2 210 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558465&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526822 471699121 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179335 OC(=O)C1CC1c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1F 558465 2-[2-Fluoro-3-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxymethyl]phenyl]cyclopropane-1-carboxylic Acid::US11365192, Example 70-3::US11365192, Example 71-45::US11365192, Example 71-46 Cytochrome P450 4F2 240 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558465&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526822 471699121 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179337 CC(C)(OCCCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C20H29N3O4/c1-20(2,19(24)25)27-14-8-6-4-3-5-7-13-26-16-9-10-17(21-15-16)18-11-12-22-23-18/h9-12,15H,3-8,13-14H2,1-2H3,(H,22,23)(H,24,25) VSZJYYPCNCLYGI-UHFFFAOYSA-N 558524 US11365192, Example 72-1 Cytochrome P450 4F2 54.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558524&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324067 471699176 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179339 OC(=O)C1(CCC1)OCCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C20H27N3O4/c24-19(25)20(10-6-11-20)27-14-5-3-1-2-4-13-26-16-7-8-17(21-15-16)18-9-12-22-23-18/h7-9,12,15H,1-6,10-11,13-14H2,(H,22,23)(H,24,25) MCUGQULJODTOLS-UHFFFAOYSA-N 558525 US11365192, Example 72-2 Cytochrome P450 4F2 97.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558525&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148459452 471699177 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179341 OC(=O)C1(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)COC1 InChI=1S/C20H27N3O4/c24-19(25)20(14-26-15-20)10-5-3-1-2-4-6-12-27-16-7-8-17(21-13-16)18-9-11-22-23-18/h7-9,11,13H,1-6,10,12,14-15H2,(H,22,23)(H,24,25) WHTOFCRPGUJAJC-UHFFFAOYSA-N 558526 US11365192, Example 72-3 Cytochrome P450 4F2 43.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558526&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 153189538 471699178 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179343 OC(=O)C1(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)CCOC1 558527 US11365192, Example 72-4 Cytochrome P450 4F2 14.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558527&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324098 471699179 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179345 OC(=O)C1(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)CCCO1 558528 US11365192, Example 72-5 Cytochrome P450 4F2 43.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558528&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324066 471699180 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179347 OC(=O)C1(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)CCS(=O)(=O)CC1 InChI=1S/C22H31N3O5S/c26-21(27)22(11-15-31(28,29)16-12-22)10-5-3-1-2-4-6-14-30-18-7-8-19(23-17-18)20-9-13-24-25-20/h7-9,13,17H,1-6,10-12,14-16H2,(H,24,25)(H,26,27) KBRYAWOXFKAIPI-UHFFFAOYSA-N 558529 US11365192, Example 72-6 Cytochrome P450 4F2 9.40 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558529&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323972 471699181 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179349 OC(=O)C1(Cc2cccc(COc3ccc(nc3)-c3ccn[nH]3)c2F)CC1 InChI=1S/C20H18FN3O3/c21-18-13(10-20(7-8-20)19(25)26)2-1-3-14(18)12-27-15-4-5-16(22-11-15)17-6-9-23-24-17/h1-6,9,11H,7-8,10,12H2,(H,23,24)(H,25,26) FXYRENIAKXTVRM-UHFFFAOYSA-N 558530 US11365192, Example 72-7 Cytochrome P450 4F2 15000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558530&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324114 471699182 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179351 OC(=O)C1(Cc2cccc(CCOc3ccc(nc3)-c3ccn[nH]3)c2F)CC1 InChI=1S/C21H20FN3O3/c22-19-14(2-1-3-15(19)12-21(8-9-21)20(26)27)7-11-28-16-4-5-17(23-13-16)18-6-10-24-25-18/h1-6,10,13H,7-9,11-12H2,(H,24,25)(H,26,27) JNIUAECEVGOCHL-UHFFFAOYSA-N 558531 US11365192, Example 72-8 Cytochrome P450 4F2 1700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558531&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324048 471699183 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179353 CC(=O)N1CCC(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)(C1)C(O)=O 558532 US11365192, Example 72-9 Cytochrome P450 4F2 18.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558532&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324095 471699184 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179355 OC(=O)C1(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)CS(=O)(=O)C1 InChI=1S/C20H27N3O5S/c24-19(25)20(14-29(26,27)15-20)10-5-3-1-2-4-6-12-28-16-7-8-17(21-13-16)18-9-11-22-23-18/h7-9,11,13H,1-6,10,12,14-15H2,(H,22,23)(H,24,25) GTGTYDVXVUVFMJ-UHFFFAOYSA-N 558533 1,1-Dioxo-3-[8-[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxyoctyl]thietane-3-carboxylic Acid::US11365192, Example 73-1 Cytochrome P450 4F2 12.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558533&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526917 471699185 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179357 OC(=O)C1(Cc2ccc(CCOc3ccc(nc3)-c3ccn[nH]3)cc2)CC1 InChI=1S/C21H21N3O3/c25-20(26)21(9-10-21)13-16-3-1-15(2-4-16)8-12-27-17-5-6-18(22-14-17)19-7-11-23-24-19/h1-7,11,14H,8-10,12-13H2,(H,23,24)(H,25,26) ZUDQOPWKENARDD-UHFFFAOYSA-N 558534 US11365192, Example 74-1 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558534&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149571158 471699186 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179359 OC(=O)C1CC1c1cc(CCOc2ccc(nc2)-c2ccn[nH]2)ccc1F 558535 US11365192, Example 74-2 Cytochrome P450 4F2 130 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558535&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323773 471699187 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179361 OC(=O)C1CC1c1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1F 558536 US11365192, Example 74-3 Cytochrome P450 4F2 60.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558536&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147678876 471699188 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179363 OC(=O)[C@H]1C[C@@H]1c1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1F 558537 US11365192, Example 74-4 Cytochrome P450 4F2 58.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558537&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147678875 471699189 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179365 OC(=O)[C@@H]1C[C@H]1c1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1F 558538 US11365192, Example 74-5 Cytochrome P450 4F2 80.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558538&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 158319820 471699190 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179367 OC(=O)C1CC1c1ccc(F)c(CCOc2ccc(nc2)-c2ccn[nH]2)c1 558539 US11365192, Example 74-6::US11365192, Example 74-7::US11365192, Example 74-8 Cytochrome P450 4F2 16000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558539&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324026 471699191 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179369 OC(=O)C1CC1c1ccc(F)c(CCOc2ccc(nc2)-c2ccn[nH]2)c1 558539 US11365192, Example 74-6::US11365192, Example 74-7::US11365192, Example 74-8 Cytochrome P450 4F2 1300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558539&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324026 471699191 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179371 OC(=O)C1CC1c1ccc(F)c(CCOc2ccc(nc2)-c2ccn[nH]2)c1 558539 US11365192, Example 74-6::US11365192, Example 74-7::US11365192, Example 74-8 Cytochrome P450 4F2 410 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558539&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324026 471699191 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179373 OC(=O)C1CC1c1cc(F)cc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 558542 US11365192, Example 74-10::US11365192, Example 74-11::US11365192, Example 74-9 Cytochrome P450 4F2 19000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558542&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487897 471699192 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179375 OC(=O)C1CC1c1cc(F)cc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 558542 US11365192, Example 74-10::US11365192, Example 74-11::US11365192, Example 74-9 Cytochrome P450 4F2 2600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558542&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487897 471699192 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179377 OC(=O)C1CC1c1cc(F)cc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 558542 US11365192, Example 74-10::US11365192, Example 74-11::US11365192, Example 74-9 Cytochrome P450 4F2 1200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558542&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487897 471699192 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179379 OC(=O)C1(Cc2ccc(CCOc3ccc(nc3)-c3ccn[nH]3)cc2)COC1 InChI=1S/C21H21N3O4/c25-20(26)21(13-27-14-21)11-16-3-1-15(2-4-16)8-10-28-17-5-6-18(22-12-17)19-7-9-23-24-19/h1-7,9,12H,8,10-11,13-14H2,(H,23,24)(H,25,26) HYRZPNMLUCQUSZ-UHFFFAOYSA-N 558545 3-[[4-[2-[6-(1H-Pyrazol-5-yl)pyridin-3-yl]oxyethyl]phenyl]methyl]oxetane-3-carboxylic Acid::US11365192, Example 74-12 Cytochrome P450 4F2 13000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558545&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142527053 471699193 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179381 CC(C)(NS(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C19H20N4O5S/c1-19(2,18(24)25)23-29(26,27)15-5-3-4-13(10-15)12-28-14-6-7-16(20-11-14)17-8-9-21-22-17/h3-11,23H,12H2,1-2H3,(H,21,22)(H,24,25) NLNIPUJZDIBMFW-UHFFFAOYSA-N 558546 US11365192, Example 75-1 Cytochrome P450 4F2 9300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558546&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324110 471699194 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179383 CN(CC(C)(C)C(O)=O)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H24N4O5S/c1-21(2,20(26)27)14-25(3)31(28,29)17-6-4-5-15(11-17)13-30-16-7-8-18(22-12-16)19-9-10-23-24-19/h4-12H,13-14H2,1-3H3,(H,23,24)(H,26,27) SODJWIBKDNXKRJ-UHFFFAOYSA-N 558547 US11365192, Example 75-2 Cytochrome P450 4F2 130 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558547&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323881 471699195 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179385 CC(C)(CNS(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C20H22N4O5S/c1-20(2,19(25)26)13-23-30(27,28)16-5-3-4-14(10-16)12-29-15-6-7-17(21-11-15)18-8-9-22-24-18/h3-11,23H,12-13H2,1-2H3,(H,22,24)(H,25,26) XLXKTNWESKYDNU-UHFFFAOYSA-N 558548 US11365192, Example 75-3 Cytochrome P450 4F2 490 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558548&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324112 471699196 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179387 CN(C(C)(C)C(O)=O)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H22N4O5S/c1-20(2,19(25)26)24(3)30(27,28)16-6-4-5-14(11-16)13-29-15-7-8-17(21-12-15)18-9-10-22-23-18/h4-12H,13H2,1-3H3,(H,22,23)(H,25,26) SRNMLVYJVUKNHT-UHFFFAOYSA-N 558549 US11365192, Example 75-4 Cytochrome P450 4F2 29000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558549&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324045 471699197 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179389 CC(C)(COc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cn1)C(O)=O InChI=1S/C19H20N4O4/c1-19(2,18(24)25)12-27-17-6-3-13(9-21-17)11-26-14-4-5-15(20-10-14)16-7-8-22-23-16/h3-10H,11-12H2,1-2H3,(H,22,23)(H,24,25) LBKXDMIKQPVFJD-UHFFFAOYSA-N 558550 US11365192, Example 75-5 Cytochrome P450 4F2 780 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558550&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323974 471699198 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179391 CC(C)(COc1cccc(COc2ccc(nc2)-c2ccn[nH]2)n1)C(O)=O InChI=1S/C19H20N4O4/c1-19(2,18(24)25)12-27-17-5-3-4-13(22-17)11-26-14-6-7-15(20-10-14)16-8-9-21-23-16/h3-10H,11-12H2,1-2H3,(H,21,23)(H,24,25) GXEBBXJDFACIAC-UHFFFAOYSA-N 558551 US11365192, Example 75-6 Cytochrome P450 4F2 1700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558551&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324060 471699199 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179393 OC(=O)C1CCc2ccc(COc3ccc(nc3)-c3[nH]ncc3Cl)cc2O1 558552 US11365192, Example 75-7::US11365192, Example 75-8 Cytochrome P450 4F2 20.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558552&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324041 471699200 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179395 OC(=O)C1CCc2ccc(COc3ccc(nc3)-c3[nH]ncc3Cl)cc2O1 558552 US11365192, Example 75-7::US11365192, Example 75-8 Cytochrome P450 4F2 67.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558552&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324041 471699200 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179397 CC(C)(OCCCCCCCOc1ccc(nc1)-c1cnco1)C(O)=O InChI=1S/C19H26N2O5/c1-19(2,18(22)23)26-11-7-5-3-4-6-10-24-15-8-9-16(21-12-15)17-13-20-14-25-17/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,22,23) QKWTWSIIYBRGPU-UHFFFAOYSA-N 558554 2-Methyl-2-[7-[6-(1,3-oxazol-5-yl)pyridin-3-yl]oxyheptoxy]propanoic Acid::US11365192, Example 76-1 Cytochrome P450 4F2 1500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558554&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526533 471699201 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179399 CC(=O)N1CCN(CCOc2ccc(cc2)-c2ccn[nH]2)CC1 InChI=1S/C17H22N4O2/c1-14(22)21-10-8-20(9-11-21)12-13-23-16-4-2-15(3-5-16)17-6-7-18-19-17/h2-7H,8-13H2,1H3,(H,18,19) JCIZCRZYSRPBNV-UHFFFAOYSA-N 558555 US11365192, Compound A Cytochrome P450 4F2 1000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558555&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 9966630 471699202 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1179401 CCOC(=O)N1CCN(CCOc2ccc(cn2)-c2ccn[nH]2)CC1 InChI=1S/C17H23N5O3/c1-2-24-17(23)22-9-7-21(8-10-22)11-12-25-16-4-3-14(13-18-16)15-5-6-19-20-15/h3-6,13H,2,7-12H2,1H3,(H,19,20) GCFIXIVAKDPTLU-UHFFFAOYSA-N 558556 US11365192, Compound B Cytochrome P450 4F2 36000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558556&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 10269081 471699203 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178481 OC(=O)c1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C16H13N3O3/c20-16(21)12-3-1-11(2-4-12)10-22-13-5-6-14(17-9-13)15-7-8-18-19-15/h1-9H,10H2,(H,18,19)(H,20,21) LGJSFJPLMGXSLN-UHFFFAOYSA-N 558096 4-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]benzoic Acid::US11365192, Example 1-1 Cytochrome P450 4F2 15000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558096&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526977 471698757 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178483 Oc1cnc(-c2ccnn2C2CCCCO2)c(F)c1 InChI=1S/C13H14FN3O2/c14-10-7-9(18)8-15-13(10)11-4-5-16-17(11)12-3-1-2-6-19-12/h4-5,7-8,12,18H,1-3,6H2 IOAOBKPTNVNDNR-UHFFFAOYSA-N 558097 US11365192, Example 1-2 Cytochrome P450 4F2 42000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558097&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790757 471698758 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178485 Cc1cc(O)cnc1-c1ccnn1C1CCCCO1 InChI=1S/C14H17N3O2/c1-10-8-11(18)9-15-14(10)12-5-6-16-17(12)13-4-2-3-7-19-13/h5-6,8-9,13,18H,2-4,7H2,1H3 CMAJQNYXSXXQKG-UHFFFAOYSA-N 558098 US11365192, Example 1-3 Cytochrome P450 4F2 220 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558098&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323803 471698759 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178487 OC(=O)CCc1ccccc1COc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C18H17N3O3/c22-18(23)8-5-13-3-1-2-4-14(13)12-24-15-6-7-16(19-11-15)17-9-10-20-21-17/h1-4,6-7,9-11H,5,8,12H2,(H,20,21)(H,22,23) LVMKABGMFIYVLK-UHFFFAOYSA-N 558099 US11365192, Example 1-4 Cytochrome P450 4F2 16000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558099&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323847 471698760 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178489 OC(=O)c1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C17H15N3O3/c21-17(22)13-3-1-12(2-4-13)8-10-23-14-5-6-15(18-11-14)16-7-9-19-20-16/h1-7,9,11H,8,10H2,(H,19,20)(H,21,22) ARBRPILVBVFVPL-UHFFFAOYSA-N 558100 US11365192, Example 1-5 Cytochrome P450 4F2 3500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558100&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146995880 471698761 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178491 OC(=O)c1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H15N3O3/c21-17(22)13-3-1-2-12(10-13)7-9-23-14-4-5-15(18-11-14)16-6-8-19-20-16/h1-6,8,10-11H,7,9H2,(H,19,20)(H,21,22) IEOOIKIDYVJKHD-UHFFFAOYSA-N 558101 US11365192, Example 1-6 Cytochrome P450 4F2 2300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558101&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323823 471698762 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178493 OC(=O)c1ccccc1CCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C17H15N3O3/c21-17(22)14-4-2-1-3-12(14)8-10-23-13-5-6-15(18-11-13)16-7-9-19-20-16/h1-7,9,11H,8,10H2,(H,19,20)(H,21,22) DMMNCSQQXLFLKW-UHFFFAOYSA-N 558102 US11365192, Example 1-7 Cytochrome P450 4F2 11000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558102&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323872 471698763 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178495 OC(=O)c1ccc(CCCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C18H17N3O3/c22-18(23)14-5-3-13(4-6-14)2-1-11-24-15-7-8-16(19-12-15)17-9-10-20-21-17/h3-10,12H,1-2,11H2,(H,20,21)(H,22,23) IUQYGWGQSSRZNL-UHFFFAOYSA-N 558103 US11365192, Example 1-8 Cytochrome P450 4F2 2600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558103&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323875 471698764 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178497 OC(=O)c1cccc(CCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H17N3O3/c22-18(23)14-5-1-3-13(11-14)4-2-10-24-15-6-7-16(19-12-15)17-8-9-20-21-17/h1,3,5-9,11-12H,2,4,10H2,(H,20,21)(H,22,23) BTAJBSYDLZWMAR-UHFFFAOYSA-N 558104 US11365192, Example 1-9 Cytochrome P450 4F2 480 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558104&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147145799 471698765 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178499 OC(=O)c1ccccc1CCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C18H17N3O3/c22-18(23)15-6-2-1-4-13(15)5-3-11-24-14-7-8-16(19-12-14)17-9-10-20-21-17/h1-2,4,6-10,12H,3,5,11H2,(H,20,21)(H,22,23) LBIMGESPEOXAJU-UHFFFAOYSA-N 558105 US11365192, Example 1-10 Cytochrome P450 4F2 27000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558105&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323991 471698766 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178501 OC(=O)CCCc1ccccc1COc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C19H19N3O3/c23-19(24)7-3-6-14-4-1-2-5-15(14)13-25-16-8-9-17(20-12-16)18-10-11-21-22-18/h1-2,4-5,8-12H,3,6-7,13H2,(H,21,22)(H,23,24) SYWRQGUVLDJAIF-UHFFFAOYSA-N 558106 US11365192, Example 1-11 Cytochrome P450 4F2 43000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558106&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323993 471698767 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178503 OC(=O)CCCCc1ccccc1COc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C20H21N3O3/c24-20(25)8-4-3-6-15-5-1-2-7-16(15)14-26-17-9-10-18(21-13-17)19-11-12-22-23-19/h1-2,5,7,9-13H,3-4,6,8,14H2,(H,22,23)(H,24,25) SFISQUMYIQPGHW-UHFFFAOYSA-N 558107 US11365192, Example 1-12 Cytochrome P450 4F2 >50000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558107&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323879 471698768 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178505 OC(=O)Cc1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C18H17N3O3/c22-18(23)11-14-3-1-13(2-4-14)8-10-24-15-5-6-16(19-12-15)17-7-9-20-21-17/h1-7,9,12H,8,10-11H2,(H,20,21)(H,22,23) POFYCLQNFQCNGJ-UHFFFAOYSA-N 558108 US11365192, Example 1-13 Cytochrome P450 4F2 2700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558108&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323824 471698769 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178507 OC(=O)Cc1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H17N3O3/c22-18(23)11-14-3-1-2-13(10-14)7-9-24-15-4-5-16(19-12-15)17-6-8-20-21-17/h1-6,8,10,12H,7,9,11H2,(H,20,21)(H,22,23) VZNZRXYIWNCYDR-UHFFFAOYSA-N 558109 US11365192, Example 1-14 Cytochrome P450 4F2 7800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558109&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323995 471698770 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178509 OC(=O)CCc1ccc(CCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C19H19N3O3/c23-19(24)8-5-14-1-3-15(4-2-14)10-12-25-16-6-7-17(20-13-16)18-9-11-21-22-18/h1-4,6-7,9,11,13H,5,8,10,12H2,(H,21,22)(H,23,24) YFZJTBZXFHBAFY-UHFFFAOYSA-N 558110 US11365192, Example 1-15 Cytochrome P450 4F2 670 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558110&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323848 471698771 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178511 OC(=O)CCc1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H19N3O3/c23-19(24)7-4-14-2-1-3-15(12-14)9-11-25-16-5-6-17(20-13-16)18-8-10-21-22-18/h1-3,5-6,8,10,12-13H,4,7,9,11H2,(H,21,22)(H,23,24) JCONJLBKXKQREC-UHFFFAOYSA-N 558111 US11365192, Example 1-16 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558111&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323885 471698772 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178513 OC(=O)CCc1ccccc1CCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C20H21N3O3/c24-20(25)10-7-16-5-2-1-4-15(16)6-3-13-26-17-8-9-18(21-14-17)19-11-12-22-23-19/h1-2,4-5,8-9,11-12,14H,3,6-7,10,13H2,(H,22,23)(H,24,25) CYLVXBOEUNTRPW-UHFFFAOYSA-N 558112 US11365192, Example 1-17 Cytochrome P450 4F2 5100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558112&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323825 471698773 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178515 OC(=O)c1ccc(CCCCOc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C19H19N3O3/c23-19(24)15-6-4-14(5-7-15)3-1-2-12-25-16-8-9-17(20-13-16)18-10-11-21-22-18/h4-11,13H,1-3,12H2,(H,21,22)(H,23,24) FXMBRPJWJYYWGG-UHFFFAOYSA-N 558113 US11365192, Example 1-18 Cytochrome P450 4F2 330 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558113&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147586711 471698774 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178517 OC(=O)c1cccc(CCCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H19N3O3/c23-19(24)15-6-3-5-14(12-15)4-1-2-11-25-16-7-8-17(20-13-16)18-9-10-21-22-18/h3,5-10,12-13H,1-2,4,11H2,(H,21,22)(H,23,24) QSQMFJRCLOGAIO-UHFFFAOYSA-N 558114 US11365192, Example 1-19 Cytochrome P450 4F2 220 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558114&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149092398 471698775 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178519 OC(=O)C12CCC(COc3ccc(nc3)-c3[nH]ncc3Cl)(CC1)CC2 InChI=1S/C18H20ClN3O3/c19-13-10-21-22-15(13)14-2-1-12(9-20-14)25-11-17-3-6-18(7-4-17,8-5-17)16(23)24/h1-2,9-10H,3-8,11H2,(H,21,22)(H,23,24) XSJRXXUPRLFDSG-UHFFFAOYSA-N 558115 US11365192, Example 1-20 Cytochrome P450 4F2 9200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558115&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323899 471698776 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178521 OC(=O)C12CCC(COc3cnc(-c4ccn[nH]4)c(F)c3)(CC1)CC2 InChI=1S/C18H20FN3O3/c19-13-9-12(10-20-15(13)14-1-8-21-22-14)25-11-17-2-5-18(6-3-17,7-4-17)16(23)24/h1,8-10H,2-7,11H2,(H,21,22)(H,23,24) FZFHCARSZIJGDV-UHFFFAOYSA-N 558116 US11365192, Example 1-21 Cytochrome P450 4F2 31000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558116&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323894 471698777 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178523 Cc1cc(OCC23CCC(CC2)(CC3)C(O)=O)cnc1-c1ccn[nH]1 InChI=1S/C19H23N3O3/c1-13-10-14(11-20-16(13)15-2-9-21-22-15)25-12-18-3-6-19(7-4-18,8-5-18)17(23)24/h2,9-11H,3-8,12H2,1H3,(H,21,22)(H,23,24) BUUQTGMPUBQFLE-UHFFFAOYSA-N 558117 US11365192, Example 1-22 Cytochrome P450 4F2 >50000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558117&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323902 471698778 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178525 OC(=O)CCC(=O)N1CCC[C@H](COc2ccc(nc2)-c2ccn[nH]2)C1 558118 US11365192, Example 1-23 Cytochrome P450 4F2 20000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558118&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323935 471698779 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178527 OC(=O)CCC(=O)N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1 558119 US11365192, Example 1-24 Cytochrome P450 4F2 15000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558119&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323998 471698780 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178529 OC(=O)Cn1cc(ccc1=O)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H18N4O4/c27-21-7-4-17(12-26(21)13-22(28)29)16-3-1-2-15(10-16)14-30-18-5-6-19(23-11-18)20-8-9-24-25-20/h1-12H,13-14H2,(H,24,25)(H,28,29) HLTLKWVQQUORFZ-UHFFFAOYSA-N 558120 US11365192, Example 1-25 Cytochrome P450 4F2 1600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558120&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112501 471698781 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178531 OC(=O)C1CC(CCOc2ccc(nc2)-c2ccn[nH]2)C1 InChI=1S/C15H17N3O3/c19-15(20)11-7-10(8-11)4-6-21-12-1-2-13(16-9-12)14-3-5-17-18-14/h1-3,5,9-11H,4,6-8H2,(H,17,18)(H,19,20) SGMNATDMZWCFFT-UHFFFAOYSA-N 558121 US11365192, Example 1-26 Cytochrome P450 4F2 14000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558121&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146842896 471698782 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178533 OC(=O)C1CC1CCCOc1ccc(nc1)-c1ccn[nH]1 558122 US11365192, Example 1-27::US11365192, Example 1-28 Cytochrome P450 4F2 41000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558122&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323849 471698783 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178535 OC(=O)C1CC1CCCOc1ccc(nc1)-c1ccn[nH]1 558122 US11365192, Example 1-27::US11365192, Example 1-28 Cytochrome P450 4F2 19000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558122&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323849 471698783 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178537 OC(=O)C1CCCC(CCCOc2ccc(nc2)-c2ccn[nH]2)C1 558124 US11365192, Example 1-29 Cytochrome P450 4F2 360 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558124&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487710 471698784 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178539 OC(=O)C12CCC(CCCOc3ccc(nc3)-c3ccn[nH]3)(CC1)CC2 InChI=1S/C20H25N3O3/c24-18(25)20-9-6-19(7-10-20,8-11-20)5-1-13-26-15-2-3-16(21-14-15)17-4-12-22-23-17/h2-4,12,14H,1,5-11,13H2,(H,22,23)(H,24,25) KHLLUDDJAGHTRP-UHFFFAOYSA-N 558125 US11365192, Example 1-30 Cytochrome P450 4F2 4100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558125&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323904 471698785 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178541 CC(C)(CC(=O)N1CCC(CCCOc2ccc(nc2)-c2ccn[nH]2)CC1)C(O)=O InChI=1S/C22H30N4O4/c1-22(2,21(28)29)14-20(27)26-11-8-16(9-12-26)4-3-13-30-17-5-6-18(23-15-17)19-7-10-24-25-19/h5-7,10,15-16H,3-4,8-9,11-14H2,1-2H3,(H,24,25)(H,28,29) LIFFUEQTVLCYLT-UHFFFAOYSA-N 558126 US11365192, Example 1-31 Cytochrome P450 4F2 160 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558126&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323942 471698786 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178543 CC(C)(CC(=O)N1CCCC(CCCOc2ccc(nc2)-c2ccn[nH]2)C1)C(O)=O 558127 US11365192, Example 1-32 Cytochrome P450 4F2 3800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558127&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 154931266 471698787 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178545 OC(=O)C1(CCCCOc2ccc(nc2)-c2ccn[nH]2)CCC1 InChI=1S/C17H21N3O3/c21-16(22)17(8-3-9-17)7-1-2-11-23-13-4-5-14(18-12-13)15-6-10-19-20-15/h4-6,10,12H,1-3,7-9,11H2,(H,19,20)(H,21,22) XKKABJBOIJNYDR-UHFFFAOYSA-N 558128 US11365192, Example 1-33 Cytochrome P450 4F2 15000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558128&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323895 471698788 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178547 OC(=O)C1(CCCCOc2ccc(nc2)-c2ccn[nH]2)CCCC1 InChI=1S/C18H23N3O3/c22-17(23)18(8-1-2-9-18)10-3-4-12-24-14-5-6-15(19-13-14)16-7-11-20-21-16/h5-7,11,13H,1-4,8-10,12H2,(H,20,21)(H,22,23) BPTOSMBBTPBKCI-UHFFFAOYSA-N 558129 US11365192, Example 1-34 Cytochrome P450 4F2 1800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558129&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323882 471698789 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178549 OC(=O)C1(CCCCOc2ccc(nc2)-c2ccn[nH]2)CCCCC1 InChI=1S/C19H25N3O3/c23-18(24)19(9-2-1-3-10-19)11-4-5-13-25-15-6-7-16(20-14-15)17-8-12-21-22-17/h6-8,12,14H,1-5,9-11,13H2,(H,21,22)(H,23,24) MQJHSSKXFZMSCC-UHFFFAOYSA-N 558130 US11365192, Example 1-35 Cytochrome P450 4F2 2200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558130&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323854 471698790 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178551 CC(C)(Oc1cccc(CCCCOc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C22H25N3O4/c1-22(2,21(26)27)29-17-8-5-7-16(14-17)6-3-4-13-28-18-9-10-19(23-15-18)20-11-12-24-25-20/h5,7-12,14-15H,3-4,6,13H2,1-2H3,(H,24,25)(H,26,27) ROWYVSCMYOATKQ-UHFFFAOYSA-N 558131 US11365192, Example 1-36 Cytochrome P450 4F2 1300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558131&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112502 471698791 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178553 OC(=O)c1cccc(c1)S(=O)(=O)N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1 558132 US11365192, Example 1-37 Cytochrome P450 4F2 94.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558132&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112503 471698792 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178555 CC(C)(CCc1cc(COc2ccc(nc2)-c2ccn[nH]2)ccn1)C(O)=O InChI=1S/C20H22N4O3/c1-20(2,19(25)26)8-5-15-11-14(6-9-21-15)13-27-16-3-4-17(22-12-16)18-7-10-23-24-18/h3-4,6-7,9-12H,5,8,13H2,1-2H3,(H,23,24)(H,25,26) APYFQBYYHWBALN-UHFFFAOYSA-N 558133 US11365192, Example 1-38 Cytochrome P450 4F2 1200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558133&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323912 471698793 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178557 CC(C)(CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)n1)C(O)=O InChI=1S/C20H22N4O3/c1-20(2,19(25)26)10-8-14-4-3-5-15(23-14)13-27-16-6-7-17(21-12-16)18-9-11-22-24-18/h3-7,9,11-12H,8,10,13H2,1-2H3,(H,22,24)(H,25,26) MSVPFMWYYKVYNL-UHFFFAOYSA-N 558134 US11365192, Example 1-39 Cytochrome P450 4F2 9800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558134&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323826 471698794 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178559 OC(=O)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccn1 InChI=1S/C15H12N4O3/c20-15(21)14-7-10(3-5-16-14)9-22-11-1-2-12(17-8-11)13-4-6-18-19-13/h1-8H,9H2,(H,18,19)(H,20,21) WROLIFSRNUCIEA-UHFFFAOYSA-N 558135 4-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]-2-pyridinecarboxylic Acid::US11365192, Example 1-40 Cytochrome P450 4F2 15000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558135&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526830 471698795 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178561 OC(=O)c1cc(COc2ccc(nc2)-c2n[nH]cc2Cl)ccn1 InChI=1S/C15H11ClN4O3/c16-11-7-19-20-14(11)12-2-1-10(6-18-12)23-8-9-3-4-17-13(5-9)15(21)22/h1-7H,8H2,(H,19,20)(H,21,22) KSIVZQWUMQTIPC-UHFFFAOYSA-N 558136 US11365192, Example 1-41 Cytochrome P450 4F2 3700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558136&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526733 471698796 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178563 OC(=O)C1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1 InChI=1S/C16H19N3O3/c20-16(21)12-3-1-11(2-4-12)10-22-13-5-6-14(17-9-13)15-7-8-18-19-15/h5-9,11-12H,1-4,10H2,(H,18,19)(H,20,21) KQKVPZWKYDARBE-UHFFFAOYSA-N 558137 US11365192, Example 1-42::US11365192, Example 1-49 Cytochrome P450 4F2 25000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558137&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148254419 471698797 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178565 CC(C)(CCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C17H23N3O3/c1-17(2,16(21)22)9-4-3-5-11-23-13-6-7-14(18-12-13)15-8-10-19-20-15/h6-8,10,12H,3-5,9,11H2,1-2H3,(H,19,20)(H,21,22) SIVPLZRSOZKVKD-UHFFFAOYSA-N 558138 2,2-Dimethyl-7-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]heptanoic Acid::US11365192, Example 1-43 Cytochrome P450 4F2 18000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558138&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487774 471698798 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178737 OC(=O)CCS(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H17N3O5S/c22-18(23)7-9-27(24,25)15-3-1-2-13(10-15)12-26-14-4-5-16(19-11-14)17-6-8-20-21-17/h1-6,8,10-11H,7,9,12H2,(H,20,21)(H,22,23) NLZULJDFLOMQST-UHFFFAOYSA-N 558224 3-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]sulfonylpropanoic Acid::US11365192, Example 14-1 Cytochrome P450 4F2 2200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558224&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526889 471698882 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178739 CC(C)(OCCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C19H27N3O4/c1-19(2,18(23)24)26-13-7-5-3-4-6-12-25-15-8-9-16(20-14-15)17-10-11-21-22-17/h8-11,14H,3-7,12-13H2,1-2H3,(H,21,22)(H,23,24) IMRNTQAZUTUQAV-UHFFFAOYSA-N 558225 2-Methyl-2-[7-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]heptoxy]propanoic Acid::US11365192, Example 15-1 Cytochrome P450 4F2 220 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558225&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526580 471698883 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178741 COC(=O)Cc1ccc(CCO)cc1 InChI=1S/C11H14O3/c1-14-11(13)8-10-4-2-9(3-5-10)6-7-12/h2-5,12H,6-8H2,1H3 VSMNIGUSIJEJSD-UHFFFAOYSA-N 558226 1-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]propyl]-4-pyrazolecarboxylic Acid::US11365192, Example 15-2 Cytochrome P450 4F2 25000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558226&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 19088515 471698884 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178743 OC(=O)c1cnn(CCCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C16H17N5O3/c22-16(23)12-9-19-21(11-12)7-1-2-8-24-13-3-4-14(17-10-13)15-5-6-18-20-15/h3-6,9-11H,1-2,7-8H2,(H,18,20)(H,22,23) PKZXZHPFHACBII-UHFFFAOYSA-N 558227 US11365192, Example 15-3 Cytochrome P450 4F2 6300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558227&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323937 471698885 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178745 OC(=O)Cn1ncc2cc(COc3ccc(nc3)-c3ccn[nH]3)ccc12 InChI=1S/C18H15N5O3/c24-18(25)10-23-17-4-1-12(7-13(17)8-21-23)11-26-14-2-3-15(19-9-14)16-5-6-20-22-16/h1-9H,10-11H2,(H,20,22)(H,24,25) BYVZWWCKLAFJPK-UHFFFAOYSA-N 558228 2-[5-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-indazolyl]acetic Acid::US11365192, Example 16-1 Cytochrome P450 4F2 1400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558228&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526512 471698886 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178747 CC(C)(C(O)=O)C(=O)N1CCc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2C1 InChI=1S/C23H24N4O4/c1-23(2,22(29)30)21(28)27-10-8-16-4-3-15(11-17(16)13-27)14-31-18-5-6-19(24-12-18)20-7-9-25-26-20/h3-7,9,11-12H,8,10,13-14H2,1-2H3,(H,25,26)(H,29,30) FEXWRQHPGYJNTK-UHFFFAOYSA-N 558229 2,2-Dimethyl-3-oxo-3-[7-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-3,4-dihydro-1H-isoquinolin-2-yl]propanoic Acid::US11365192, Example 17-1 Cytochrome P450 4F2 180 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558229&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526985 471698887 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178749 OC(=O)c1cccc(n1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H16N4O3/c26-21(27)20-6-2-5-17(24-20)15-4-1-3-14(11-15)13-28-16-7-8-18(22-12-16)19-9-10-23-25-19/h1-12H,13H2,(H,23,25)(H,26,27) BRZSHHCZTXJLLX-UHFFFAOYSA-N 558230 6-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-2-pyridinecarboxylic Acid::US11365192, Example 18-1 Cytochrome P450 4F2 460 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558230&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112526 471698888 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178751 OC(=O)c1ccc(nc1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H16N4O3/c26-21(27)16-4-6-18(22-11-16)15-3-1-2-14(10-15)13-28-17-5-7-19(23-12-17)20-8-9-24-25-20/h1-12H,13H2,(H,24,25)(H,26,27) UQVHCGVJLGKALZ-UHFFFAOYSA-N 558231 US11365192, Example 18-2 Cytochrome P450 4F2 230 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558231&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112527 471698889 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178753 OC(=O)c1cncc(n1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H15N5O3/c26-20(27)19-11-21-10-18(24-19)14-3-1-2-13(8-14)12-28-15-4-5-16(22-9-15)17-6-7-23-25-17/h1-11H,12H2,(H,23,25)(H,26,27) UOCYNNFLZZOJSC-UHFFFAOYSA-N 558232 US11365192, Example 18-3 Cytochrome P450 4F2 510 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558232&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112528 471698890 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178755 OC(=O)c1cnc(cn1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H15N5O3/c26-20(27)19-11-22-18(10-23-19)14-3-1-2-13(8-14)12-28-15-4-5-16(21-9-15)17-6-7-24-25-17/h1-11H,12H2,(H,24,25)(H,26,27) AETOVNZIRSHXPU-UHFFFAOYSA-N 558233 US11365192, Example 18-4 Cytochrome P450 4F2 490 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558233&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112529 471698891 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178757 CC(C)(Oc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C19H19N3O4/c1-19(2,18(23)24)26-14-5-3-4-13(10-14)12-25-15-6-7-16(20-11-15)17-8-9-21-22-17/h3-11H,12H2,1-2H3,(H,21,22)(H,23,24) GJCLVDRSLUNIBU-UHFFFAOYSA-N 558234 US11365192, Example 18-5 Cytochrome P450 4F2 5200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558234&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112530 471698892 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178759 OC(=O)c1cccc(OCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H15N3O4/c21-17(22)12-2-1-3-13(10-12)23-8-9-24-14-4-5-15(18-11-14)16-6-7-19-20-16/h1-7,10-11H,8-9H2,(H,19,20)(H,21,22) XKUGPHLLSJKYCN-UHFFFAOYSA-N 558235 US11365192, Example 18-6 Cytochrome P450 4F2 6100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558235&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112531 471698893 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178761 CS(=O)(=O)NCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C15H22N4O3S/c1-23(20,21)18-9-4-2-3-5-11-22-13-6-7-14(16-12-13)15-8-10-17-19-15/h6-8,10,12,18H,2-5,9,11H2,1H3,(H,17,19) KARZCKAGWYTWDA-UHFFFAOYSA-N 558236 N-[6-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]hexyl]methanesulfonamide::US11365192, Example 19-1 Cytochrome P450 4F2 22.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558236&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142527013 471698894 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178763 CS(=O)(=O)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1O InChI=1S/C16H15N3O4S/c1-24(21,22)16-8-11(2-5-15(16)20)10-23-12-3-4-13(17-9-12)14-6-7-18-19-14/h2-9,20H,10H2,1H3,(H,18,19) LDNKJTORMDNTFO-UHFFFAOYSA-N 558237 2-Methylsulfonyl-4-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenol::US11365192, Example 20-1 Cytochrome P450 4F2 1100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558237&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658423 471698895 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178765 COC(=O)c1cccc(CCO)c1 InChI=1S/C10H12O3/c1-13-10(12)9-4-2-3-8(7-9)5-6-11/h2-4,7,11H,5-6H2,1H3 RJEWIMDQAGWVGW-UHFFFAOYSA-N 558238 US11365192, Example 20-2 Cytochrome P450 4F2 69.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558238&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 10535371 471698896 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178767 OC(=O)Cc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C17H15N3O3/c21-17(22)9-12-1-3-13(4-2-12)11-23-14-5-6-15(18-10-14)16-7-8-19-20-16/h1-8,10H,9,11H2,(H,19,20)(H,21,22) JAADWLLUHFTNAS-UHFFFAOYSA-N 558239 2-[4-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]acetic Acid::US11365192, Example 21-1 Cytochrome P450 4F2 15000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558239&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526704 471698897 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178769 OC(=O)Cc1ccccc1COc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C17H15N3O3/c21-17(22)9-12-3-1-2-4-13(12)11-23-14-5-6-15(18-10-14)16-7-8-19-20-16/h1-8,10H,9,11H2,(H,19,20)(H,21,22) JKAMXJZEOFYWPC-UHFFFAOYSA-N 558240 US11365192, Example 21-2 Cytochrome P450 4F2 >50000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558240&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323939 471698898 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178771 OC(=O)C1(CC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C19H17N3O3/c23-18(24)19(7-8-19)14-3-1-2-13(10-14)12-25-15-4-5-16(20-11-15)17-6-9-21-22-17/h1-6,9-11H,7-8,12H2,(H,21,22)(H,23,24) RBRMRMJXNOYSAG-UHFFFAOYSA-N 558241 US11365192, Example 21-3 Cytochrome P450 4F2 21000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558241&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324056 471698899 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178773 CC(C)(CCNS(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(O)=O InChI=1S/C21H24N4O5S/c1-21(2,20(26)27)9-11-24-31(28,29)17-5-3-4-15(12-17)14-30-16-6-7-18(22-13-16)19-8-10-23-25-19/h3-8,10,12-13,24H,9,11,14H2,1-2H3,(H,23,25)(H,26,27) BWOSGBJWKMSINJ-UHFFFAOYSA-N 558242 US11365192, Example 21-4 Cytochrome P450 4F2 1500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558242&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323843 471698900 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178775 CN(CCC(C)(C)C(O)=O)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H26N4O5S/c1-22(2,21(27)28)10-12-26(3)32(29,30)18-6-4-5-16(13-18)15-31-17-7-8-19(23-14-17)20-9-11-24-25-20/h4-9,11,13-14H,10,12,15H2,1-3H3,(H,24,25)(H,27,28) JWGHSNKLGFKQRS-UHFFFAOYSA-N 558243 US11365192, Example 21-5 Cytochrome P450 4F2 430 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558243&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148137447 471698901 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178777 OC(=O)\C=C\c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H15N3O3/c22-18(23)7-4-13-2-1-3-14(10-13)12-24-15-5-6-16(19-11-15)17-8-9-20-21-17/h1-11H,12H2,(H,20,21)(H,22,23)/b7-4+ GCLWOVMHRIJFCU-QPJJXVBHSA-N 558244 (2E)-3-[3-[[[6-(1H-Pyrazol-5-yl)pyridin-3-yl]oxy]methyl]phenyl]-2-propenoic Acid::US11365192, Example 22-1 Cytochrome P450 4F2 140 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558244&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526528 471698902 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178779 OC(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C16H13N3O3/c20-16(21)12-3-1-2-11(8-12)10-22-13-4-5-14(17-9-13)15-6-7-18-19-15/h1-9H,10H2,(H,18,19)(H,20,21) QNNYBZOUHWALKJ-UHFFFAOYSA-N 558245 US11365192, Example 22-2 Cytochrome P450 4F2 1400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558245&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324054 471698903 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178781 OC(=O)Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H15N3O3/c21-17(22)9-12-2-1-3-13(8-12)11-23-14-4-5-15(18-10-14)16-6-7-19-20-16/h1-8,10H,9,11H2,(H,19,20)(H,21,22) ZTKBSUUOLXRMTQ-UHFFFAOYSA-N 558246 US11365192, Example 22-3 Cytochrome P450 4F2 17000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558246&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323842 471698904 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178783 OC(=O)CCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H17N3O3/c22-18(23)7-4-13-2-1-3-14(10-13)12-24-15-5-6-16(19-11-15)17-8-9-20-21-17/h1-3,5-6,8-11H,4,7,12H2,(H,20,21)(H,22,23) UFISRNUDHRNBFV-UHFFFAOYSA-N 558247 US11365192, Example 22-4 Cytochrome P450 4F2 1400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558247&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323844 471698905 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178785 OC(=O)c1cnc(nc1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H15N5O3/c26-20(27)15-9-22-19(23-10-15)14-3-1-2-13(8-14)12-28-16-4-5-17(21-11-16)18-6-7-24-25-18/h1-11H,12H2,(H,24,25)(H,26,27) QZCJHJZFDJNRTR-UHFFFAOYSA-N 558248 2-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-5-pyrimidinecarboxylic Acid::US11365192, Example 22-5 Cytochrome P450 4F2 3100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558248&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112532 471698906 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178787 OC(=O)c1ccnc(n1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H15N5O3/c26-20(27)18-6-8-21-19(24-18)14-3-1-2-13(10-14)12-28-15-4-5-16(22-11-15)17-7-9-23-25-17/h1-11H,12H2,(H,23,25)(H,26,27) VJSLQCKXQNWTLP-UHFFFAOYSA-N 558249 US11365192, Example 22-6 Cytochrome P450 4F2 3100 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558249&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112533 471698907 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178789 OC(=O)c1ncc(cn1)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H15N5O3/c26-20(27)19-22-9-15(10-23-19)14-3-1-2-13(8-14)12-28-16-4-5-17(21-11-16)18-6-7-24-25-18/h1-11H,12H2,(H,24,25)(H,26,27) YMPSAJINEGTSRW-UHFFFAOYSA-N 558250 US11365192, Example 22-7 Cytochrome P450 4F2 1200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558250&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112534 471698908 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178791 OC(=O)C1CCN(CC1)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C21H22N4O5S/c26-21(27)16-7-10-25(11-8-16)31(28,29)18-3-1-2-15(12-18)14-30-17-4-5-19(22-13-17)20-6-9-23-24-20/h1-6,9,12-13,16H,7-8,10-11,14H2,(H,23,24)(H,26,27) BKKVHJUIFWGXFP-UHFFFAOYSA-N 558251 US11365192, Example 22-8 Cytochrome P450 4F2 1500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558251&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324058 471698909 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178567 OC(=O)C1(CCCCCCOc2ccc(nc2)-c2ccn[nH]2)CCCCC1 InChI=1S/C21H29N3O3/c25-20(26)21(12-5-3-6-13-21)11-4-1-2-7-15-27-17-8-9-18(22-16-17)19-10-14-23-24-19/h8-10,14,16H,1-7,11-13,15H2,(H,23,24)(H,25,26) MDYBQGSYSVHPEL-UHFFFAOYSA-N 558139 US11365192, Example 1-44 Cytochrome P450 4F2 510 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558139&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148465463 471698799 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178569 OC(=O)C1(CCCCCCCOc2ccc(nc2)-c2ccn[nH]2)CCCC1 InChI=1S/C21H29N3O3/c25-20(26)21(12-5-6-13-21)11-4-2-1-3-7-15-27-17-8-9-18(22-16-17)19-10-14-23-24-19/h8-10,14,16H,1-7,11-13,15H2,(H,23,24)(H,25,26) XKIDFYVYLPHDNS-UHFFFAOYSA-N 558140 US11365192, Example 1-45 Cytochrome P450 4F2 19.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558140&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149231180 471698800 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178571 OC(=O)C1(CCCCCCOc2ccc(nc2)-c2ccn[nH]2)CCCC1 InChI=1S/C20H27N3O3/c24-19(25)20(11-4-5-12-20)10-3-1-2-6-14-26-16-7-8-17(21-15-16)18-9-13-22-23-18/h7-9,13,15H,1-6,10-12,14H2,(H,22,23)(H,24,25) RRMTVZMUMZAEIN-UHFFFAOYSA-N 558141 1-[6-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]hexyl]-1-cyclopentanecarboxylic Acid::US11365192, Example 1-46 Cytochrome P450 4F2 370 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558141&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526697 471698801 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178573 OC(=O)CCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C14H17N3O3/c18-14(19)4-2-1-3-9-20-11-5-6-12(15-10-11)13-7-8-16-17-13/h5-8,10H,1-4,9H2,(H,16,17)(H,18,19) ICWUAABEXSQMGT-UHFFFAOYSA-N 558142 6-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]hexanoic Acid::US11365192, Example 1-47 Cytochrome P450 4F2 14000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558142&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142527040 471698802 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178575 OC(=O)CCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C16H21N3O3/c20-16(21)6-4-2-1-3-5-11-22-13-7-8-14(17-12-13)15-9-10-18-19-15/h7-10,12H,1-6,11H2,(H,18,19)(H,20,21) SXLOFSQMAFPKQS-UHFFFAOYSA-N 558143 US11365192, Example 1-48 Cytochrome P450 4F2 2000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558143&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323911 471698803 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178577 OC(=O)C1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1 InChI=1S/C16H19N3O3/c20-16(21)12-3-1-11(2-4-12)10-22-13-5-6-14(17-9-13)15-7-8-18-19-15/h5-9,11-12H,1-4,10H2,(H,18,19)(H,20,21) KQKVPZWKYDARBE-UHFFFAOYSA-N 558137 US11365192, Example 1-42::US11365192, Example 1-49 Cytochrome P450 4F2 24000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558137&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148254419 471698797 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178579 OC(=O)[C@@H]1CC[C@H](COc2ccc(nc2)-c2ccn[nH]2)CC1 558145 US11365192, Example 1-50 Cytochrome P450 4F2 23000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558145&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148254419 471698804 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178581 OC(=O)CCCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C17H23N3O3/c21-17(22)7-5-3-1-2-4-6-12-23-14-8-9-15(18-13-14)16-10-11-19-20-16/h8-11,13H,1-7,12H2,(H,19,20)(H,21,22) MDNSZSBZPSMWLF-UHFFFAOYSA-N 558146 US11365192, Example 1-51 Cytochrome P450 4F2 200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558146&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 154931116 471698805 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178583 OC(=O)CCCCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C18H25N3O3/c22-18(23)8-6-4-2-1-3-5-7-13-24-15-9-10-16(19-14-15)17-11-12-20-21-17/h9-12,14H,1-8,13H2,(H,20,21)(H,22,23) ILFGGYOGUTYDBS-UHFFFAOYSA-N 558147 US11365192, Example 1-52 Cytochrome P450 4F2 41.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558147&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147938201 471698806 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178585 OC(=O)C12CC(CCCCCCOc3ccc(nc3)-c3ccn[nH]3)(C1)C2 InChI=1S/C20H25N3O3/c24-18(25)20-12-19(13-20,14-20)8-3-1-2-4-10-26-15-5-6-16(21-11-15)17-7-9-22-23-17/h5-7,9,11H,1-4,8,10,12-14H2,(H,22,23)(H,24,25) AWUXWPYNFDVPMO-UHFFFAOYSA-N 558148 US11365192, Example 1-53 Cytochrome P450 4F2 330 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558148&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487681 471698807 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178587 OC(=O)C1CCCC(COc2ccc(nc2)-c2ccn[nH]2)C1 558149 US11365192, Example 1-54::US11365192, Example 9-1 Cytochrome P450 4F2 3400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558149&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658384 471698808 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178589 OC(=O)C12CC(CCCOc3ccc(nc3)-c3ccn[nH]3)(C1)CCC2 InChI=1S/C19H23N3O3/c23-17(24)19-8-1-6-18(12-19,13-19)7-2-10-25-14-3-4-15(20-11-14)16-5-9-21-22-16/h3-5,9,11H,1-2,6-8,10,12-13H2,(H,21,22)(H,23,24) NYYUNSRDYIJZQE-UHFFFAOYSA-N 558150 US11365192, Example 1-55 Cytochrome P450 4F2 3700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558150&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324002 471698809 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178591 OC(=O)C1CCc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2C1 558151 US11365192, Example 1-56 Cytochrome P450 4F2 170 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558151&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112504 471698810 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178593 CC(C)(COCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C19H27N3O4/c1-19(2,18(23)24)14-25-11-5-3-4-6-12-26-15-7-8-16(20-13-15)17-9-10-21-22-17/h7-10,13H,3-6,11-12,14H2,1-2H3,(H,21,22)(H,23,24) OBUOJMNMVGAOLO-UHFFFAOYSA-N 558152 2,2-Dimethyl-3-[6-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]hexoxy]propanoic Acid::US11365192, Example 1-57 Cytochrome P450 4F2 340 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558152&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487728 471698811 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178595 OC(=O)Cn1ccc(cc1=O)-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H18N4O4/c27-21-11-17(7-9-26(21)13-22(28)29)16-3-1-2-15(10-16)14-30-18-4-5-19(23-12-18)20-6-8-24-25-20/h1-12H,13-14H2,(H,24,25)(H,28,29) UPWPVKFHFKLIBT-UHFFFAOYSA-N 558153 US11365192, Example 1-58 Cytochrome P450 4F2 650 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558153&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112505 471698812 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178597 CC(C)(CCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C16H21N3O3/c1-16(2,15(20)21)8-3-4-10-22-12-5-6-13(17-11-12)14-7-9-18-19-14/h5-7,9,11H,3-4,8,10H2,1-2H3,(H,18,19)(H,20,21) JUEJKSXASQQTGE-UHFFFAOYSA-N 558154 US11365192, Example 1-59 Cytochrome P450 4F2 17000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558154&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323964 471698813 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178599 CC(C)(CCCOc1ccc(nc1)-c1ccn[nH]1)CC(O)=O InChI=1S/C16H21N3O3/c1-16(2,10-15(20)21)7-3-9-22-12-4-5-13(17-11-12)14-6-8-18-19-14/h4-6,8,11H,3,7,9-10H2,1-2H3,(H,18,19)(H,20,21) PMMADBUDCKTOCV-UHFFFAOYSA-N 558155 US11365192, Example 1-60 Cytochrome P450 4F2 31000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558155&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324022 471698814 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178601 CC(C)(CCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C18H25N3O3/c1-18(2,17(22)23)10-5-3-4-6-12-24-14-7-8-15(19-13-14)16-9-11-20-21-16/h7-9,11,13H,3-6,10,12H2,1-2H3,(H,20,21)(H,22,23) LSTAMSMNWAGULN-UHFFFAOYSA-N 558156 2,2-Dimethyl-8-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]octanoic Acid::US11365192, Example 1-61 Cytochrome P450 4F2 1900 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558156&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526721 471698815 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178603 CC(C)(CCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C19H27N3O3/c1-19(2,18(23)24)11-6-4-3-5-7-13-25-15-8-9-16(20-14-15)17-10-12-21-22-17/h8-10,12,14H,3-7,11,13H2,1-2H3,(H,21,22)(H,23,24) ZDLQUNCWXWBJTP-UHFFFAOYSA-N 558157 US11365192, Example 1-62 Cytochrome P450 4F2 96.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558157&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149482052 471698816 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178605 CC(C)(CCCCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C20H29N3O3/c1-20(2,19(24)25)12-7-5-3-4-6-8-14-26-16-9-10-17(21-15-16)18-11-13-22-23-18/h9-11,13,15H,3-8,12,14H2,1-2H3,(H,22,23)(H,24,25) PUVOFSHIGCWIQO-UHFFFAOYSA-N 558158 US11365192, Example 1-63 Cytochrome P450 4F2 8.90 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558158&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148976162 471698817 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178607 CCC(CC)(CCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C18H25N3O3/c1-3-18(4-2,17(22)23)10-5-6-12-24-14-7-8-15(19-13-14)16-9-11-20-21-16/h7-9,11,13H,3-6,10,12H2,1-2H3,(H,20,21)(H,22,23) FHUNEDDGTJHMFD-UHFFFAOYSA-N 558159 2,2-Diethyl-6-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]hexanoic Acid::US11365192, Example 1-64 Cytochrome P450 4F2 7500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558159&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526641 471698818 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178609 COc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1C(O)=O InChI=1S/C17H15N3O4/c1-23-16-5-2-11(8-13(16)17(21)22)10-24-12-3-4-14(18-9-12)15-6-7-19-20-15/h2-9H,10H2,1H3,(H,19,20)(H,21,22) KQKNNWYSZXEKPV-UHFFFAOYSA-N 558160 2-Methoxy-5-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]benzoic Acid::US11365192, Example 1-65 Cytochrome P450 4F2 24000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558160&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526983 471698819 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178611 CC(C)(Oc1cccc(COc2ccc(nc2)-c2ccn[nH]2)n1)C(O)=O InChI=1S/C18H18N4O4/c1-18(2,17(23)24)26-16-5-3-4-12(21-16)11-25-13-6-7-14(19-10-13)15-8-9-20-22-15/h3-10H,11H2,1-2H3,(H,20,22)(H,23,24) CZCDAIQULGQUQF-UHFFFAOYSA-N 558161 US11365192, Example 1-66 Cytochrome P450 4F2 >50000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558161&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112506 471698820 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178613 CC(C)(OCCOCCCCOc1ccc(nc1)-c1ccn[nH]1)C(O)=O InChI=1S/C18H25N3O5/c1-18(2,17(22)23)26-12-11-24-9-3-4-10-25-14-5-6-15(19-13-14)16-7-8-20-21-16/h5-8,13H,3-4,9-12H2,1-2H3,(H,20,21)(H,22,23) XWTUSJOSZLAIMO-UHFFFAOYSA-N 558162 US11365192, Example 1-67 Cytochrome P450 4F2 10000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558162&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323965 471698821 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178615 OC(=O)C1COc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2C1 558163 US11365192, Example 1-68 Cytochrome P450 4F2 640 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558163&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112507 471698822 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178617 OC(=O)C1CCc2cc(COc3ccc(nc3)-c3ccn[nH]3)ccc2O1 558164 US11365192, Example 1-69 Cytochrome P450 4F2 3000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558164&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112508 471698823 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178619 OC(=O)C1CCc2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2O1 558165 US11365192, Example 1-70 Cytochrome P450 4F2 140 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558165&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112509 471698824 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178621 OC(=O)[C@@]12CC3C[C@@H](C1)[C@@H](COc1ccc(nc1)-c1ccn[nH]1)[C@H](C3)C2 558166 US11365192, Example 2-1::trans-4-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-adamantanecarboxylic Acid Cytochrome P450 4F2 24000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558166&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658456 471698825 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178793 OC(=O)C1CCCN(C1)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558252 US11365192, Example 22-9 Cytochrome P450 4F2 180 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558252&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148003405 471698910 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178795 OC(=O)C1CCN(C1)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558253 US11365192, Example 22-10 Cytochrome P450 4F2 2000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558253&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323963 471698911 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178797 OC(=O)C1(F)CCN(C1)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558254 US11365192, Example 22-11 Cytochrome P450 4F2 700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558254&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 153089248 471698912 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178799 OC(=O)C1CN(CCO1)S(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558255 US11365192, Example 22-12 Cytochrome P450 4F2 2000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558255&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324020 471698913 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178801 CC(C)(Oc1cc(COc2ccc(nc2)-c2ccn[nH]2)ccn1)C(O)=O InChI=1S/C18H18N4O4/c1-18(2,17(23)24)26-16-9-12(5-7-19-16)11-25-13-3-4-14(20-10-13)15-6-8-21-22-15/h3-10H,11H2,1-2H3,(H,21,22)(H,23,24) UVRIPDCGGUVCPM-UHFFFAOYSA-N 558256 2-Methyl-2-[[4-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]-2-pyridinyl]oxy]propanoic Acid::US11365192, Example 22-13 Cytochrome P450 4F2 11000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558256&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487638 471698914 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178803 CC(C)(COc1cc(COc2ccc(nc2)-c2ccn[nH]2)ccn1)C(O)=O InChI=1S/C19H20N4O4/c1-19(2,18(24)25)12-27-17-9-13(5-7-20-17)11-26-14-3-4-15(21-10-14)16-6-8-22-23-16/h3-10H,11-12H2,1-2H3,(H,22,23)(H,24,25) KRWFFDRHKXQAFP-UHFFFAOYSA-N 558257 US11365192, Example 22-14 Cytochrome P450 4F2 380 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558257&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487617 471698915 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178805 OC(=O)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1F InChI=1S/C16H12FN3O3/c17-13-3-1-10(7-12(13)16(21)22)9-23-11-2-4-14(18-8-11)15-5-6-19-20-15/h1-8H,9H2,(H,19,20)(H,21,22) AMANAFYPTXXEOY-UHFFFAOYSA-N 558258 US11365192, Example 22-15 Cytochrome P450 4F2 14000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558258&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323960 471698916 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178807 OC(=O)c1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1Cl InChI=1S/C16H12ClN3O3/c17-13-3-1-10(7-12(13)16(21)22)9-23-11-2-4-14(18-8-11)15-5-6-19-20-15/h1-8H,9H2,(H,19,20)(H,21,22) MLDZQJQBZCFPAF-UHFFFAOYSA-N 558259 US11365192, Example 22-16 Cytochrome P450 4F2 33000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558259&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324003 471698917 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178809 COc1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1C(O)=O InChI=1S/C17H15N3O4/c1-23-16-8-11(2-4-13(16)17(21)22)10-24-12-3-5-14(18-9-12)15-6-7-19-20-15/h2-9H,10H2,1H3,(H,19,20)(H,21,22) LCBHRZACPBZXKG-UHFFFAOYSA-N 558260 2-Methoxy-4-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]benzoic Acid::US11365192, Example 22-17 Cytochrome P450 4F2 19000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558260&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526497 471698918 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178811 OC(=O)c1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1F InChI=1S/C16H12FN3O3/c17-13-7-10(1-3-12(13)16(21)22)9-23-11-2-4-14(18-8-11)15-5-6-19-20-15/h1-8H,9H2,(H,19,20)(H,21,22) LJOWGUCCSRXFLB-UHFFFAOYSA-N 558261 US11365192, Example 22-18 Cytochrome P450 4F2 18000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558261&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323880 471698919 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178813 OC(=O)Cc1cccc(OCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H17N3O4/c22-18(23)11-13-2-1-3-14(10-13)24-8-9-25-15-4-5-16(19-12-15)17-6-7-20-21-17/h1-7,10,12H,8-9,11H2,(H,20,21)(H,22,23) OPGLGCFATHNJGM-UHFFFAOYSA-N 558262 2-[3-[2-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]ethoxy]phenyl] acetic Acid::US11365192, Example 22-19 Cytochrome P450 4F2 1500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558262&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526797 471698920 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178815 OC(=O)CCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C15H19N3O3/c19-15(20)5-3-1-2-4-10-21-12-6-7-13(16-11-12)14-8-9-17-18-14/h6-9,11H,1-5,10H2,(H,17,18)(H,19,20) SJPWIHXZXKUMJP-UHFFFAOYSA-N 558263 7-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]heptanoic Acid::US11365192, Example 22-20 Cytochrome P450 4F2 9600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558263&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526524 471698921 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178817 CNS(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C16H16N4O3S/c1-17-24(21,22)14-4-2-3-12(9-14)11-23-13-5-6-15(18-10-13)16-7-8-19-20-16/h2-10,17H,11H2,1H3,(H,19,20) BPCXHIWIPVDHCA-UHFFFAOYSA-N 558264 N-Methyl-3-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]benzenesulfonamide::US11365192, Example 23-1 Cytochrome P450 4F2 220 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558264&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658394 471698922 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178819 CC(=O)Oc1cc(CO)ccc1F InChI=1S/C9H9FO3/c1-6(12)13-9-4-7(5-11)2-3-8(9)10/h2-4,11H,5H2,1H3 ULFGMFLRVOTJOL-UHFFFAOYSA-N 558265 N-Methyl-3-[[methyl-[3-[[6-(1-H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl] sulfonylamino]methyl]benzenesulfonamide::US11365192, Example 23-2 Cytochrome P450 4F2 3.00 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558265&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 152932342 471698923 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178821 CC(=O)Oc1cc(F)cc(CO)c1 InChI=1S/C9H9FO3/c1-6(12)13-9-3-7(5-11)2-8(10)4-9/h2-4,11H,5H2,1H3 GOHQAWPBNZJBIU-UHFFFAOYSA-N 558266 US11365192, Example 23-3 Cytochrome P450 4F2 49.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558266&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 118269493 471698924 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178823 OCc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C16H15N3O2/c20-10-12-1-3-13(4-2-12)11-21-14-5-6-15(17-9-14)16-7-8-18-19-16/h1-9,20H,10-11H2,(H,18,19) ISSKORVXJPLAIR-UHFFFAOYSA-N 558267 US11365192, Example 23-4 Cytochrome P450 4F2 51.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558267&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323945 471698925 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178825 OCc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C16H15N3O2/c20-10-12-2-1-3-13(8-12)11-21-14-4-5-15(17-9-14)16-6-7-18-19-16/h1-9,20H,10-11H2,(H,18,19) MVPNWANKDSRIQZ-UHFFFAOYSA-N 558268 US11365192, Example 23-5 Cytochrome P450 4F2 130 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558268&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148564320 471698926 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178827 Fc1ccc(NS(=O)(=O)c2ccc(COc3ccc(nc3)-c3ccn[nH]3)cc2)cc1 InChI=1S/C21H17FN4O3S/c22-16-3-5-17(6-4-16)26-30(27,28)19-8-1-15(2-9-19)14-29-18-7-10-20(23-13-18)21-11-12-24-25-21/h1-13,26H,14H2,(H,24,25) NYGHHBIMNIGOQC-UHFFFAOYSA-N 558269 US11365192, Example 23-6 Cytochrome P450 4F2 6.40 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558269&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112535 471698927 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178829 CC(C(=O)[Na]O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558270 Sodium 2-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]propanoate::US11365192, Example 24-1 Cytochrome P450 4F2 13000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558270&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 160220263 471698928 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178831 OCCc1cccc(OCc2ccccc2)c1 InChI=1S/C15H16O2/c16-10-9-13-7-4-8-15(11-13)17-12-14-5-2-1-3-6-14/h1-8,11,16H,9-10,12H2 RHHVCIKVRLMNFC-UHFFFAOYSA-N 558271 Sodium 2-methyl-2-[3-[[6-(1H-pyrazol-5-yl)-3-pyridinyl] oxymethyl]phenyl]propanoate::US11365192, Example 24-2 Cytochrome P450 4F2 3500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558271&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 20402544 471698929 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178833 CC(C)(C(O)=O)c1cccc(OCCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H21N3O4/c1-20(2,19(24)25)14-4-3-5-15(12-14)26-10-11-27-16-6-7-17(21-13-16)18-8-9-22-23-18/h3-9,12-13H,10-11H2,1-2H3,(H,22,23)(H,24,25) ZXFSMIXJGFJDNV-UHFFFAOYSA-N 558272 US11365192, Example 24-3 Cytochrome P450 4F2 3200 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558272&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112536 471698930 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178835 Cc1cc(COc2ccc(nc2)-c2ccn[nH]2)ccc1C(O)=O InChI=1S/C17H15N3O3/c1-11-8-12(2-4-14(11)17(21)22)10-23-13-3-5-15(18-9-13)16-6-7-19-20-16/h2-9H,10H2,1H3,(H,19,20)(H,21,22) IXVQLQLPWZVTOQ-UHFFFAOYSA-N 558273 2-Methyl-4-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxymethyl]benzoic Acid::US11365192, Example 25-1 Cytochrome P450 4F2 16000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558273&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487830 471698931 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178837 OC(=O)C1CC1c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558274 US11365192, Example 26-1::US11365192, Example 26-2::US11365192, Example 26-3::trans-2-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-cyclopropanecarboxylic Acid Cytochrome P450 4F2 400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558274&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487599 471698932 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178839 OC(=O)C1CC1c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558274 US11365192, Example 26-1::US11365192, Example 26-2::US11365192, Example 26-3::trans-2-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-cyclopropanecarboxylic Acid Cytochrome P450 4F2 890 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558274&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487599 471698932 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178841 OC(=O)C1CC1c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558274 US11365192, Example 26-1::US11365192, Example 26-2::US11365192, Example 26-3::trans-2-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-cyclopropanecarboxylic Acid Cytochrome P450 4F2 1500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558274&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487599 471698932 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178843 CC(C)(O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C18H19N3O2/c1-18(2,22)14-5-3-4-13(10-14)12-23-15-6-7-16(19-11-15)17-8-9-20-21-17/h3-11,22H,12H2,1-2H3,(H,20,21) KEMJKHGTULZECD-UHFFFAOYSA-N 558277 2-[3-[[6-(1-H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-2-propanol::US11365192, Example 27-1 Cytochrome P450 4F2 400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558277&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487641 471698933 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178845 CC(O)(c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1)C(F)(F)F 558278 US11365192, Example 27-2 Cytochrome P450 4F2 300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558278&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 154931056 471698934 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178623 OC(=O)[C@@]12CC3C[C@@H](C1)[C@H](COc1ccc(nc1)-c1ccn[nH]1)[C@H](C3)C2 558167 US11365192, Example 2-2::cis-4-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]-1-adamantanecarboxylic Acid Cytochrome P450 4F2 >50000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558167&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658456 471698826 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178625 OC(=O)C1(CCCC1)OCCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C21H29N3O4/c25-20(26)21(11-4-5-12-21)28-15-7-3-1-2-6-14-27-17-8-9-18(22-16-17)19-10-13-23-24-19/h8-10,13,16H,1-7,11-12,14-15H2,(H,23,24)(H,25,26) XNDPBBNXQVEEFA-UHFFFAOYSA-N 558168 US11365192, Example 2-3 Cytochrome P450 4F2 75.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558168&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 149246175 471698827 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178627 OC(=O)C1(CCCC1)OCCOCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C20H27N3O5/c24-19(25)20(8-1-2-9-20)28-14-13-26-11-3-4-12-27-16-5-6-17(21-15-16)18-7-10-22-23-18/h5-7,10,15H,1-4,8-9,11-14H2,(H,22,23)(H,24,25) DTZAWMBLAHXIMF-UHFFFAOYSA-N 558169 US11365192, Example 2-4 Cytochrome P450 4F2 1800 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558169&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323828 471698828 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178629 OC(=O)CCc1ccccc1CCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C19H19N3O3/c23-19(24)8-5-14-3-1-2-4-15(14)10-12-25-16-6-7-17(20-13-16)18-9-11-21-22-18/h1-4,6-7,9,11,13H,5,8,10,12H2,(H,21,22)(H,23,24) UQTVNLWJLAALOK-UHFFFAOYSA-N 558170 3-[2-[2-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]ethyl]phenyl]propanoic Acid::US11365192, Example 2-5 Cytochrome P450 4F2 8600 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558170&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526945 471698829 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178631 OC(=O)CCC1CCCC(COc2ccc(nc2)-c2ccn[nH]2)C1 558171 US11365192, Example 2-6::cis-3-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]cyclohexyl]propanoic Acid (Racemate) Cytochrome P450 4F2 1300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558171&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 146658443 471698830 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178633 OC(=O)CCC12CCC(COc3ccc(nc3)-c3ccn[nH]3)(CC1)CC2 InChI=1S/C20H25N3O3/c24-18(25)3-5-19-6-9-20(10-7-19,11-8-19)14-26-15-1-2-16(21-13-15)17-4-12-22-23-17/h1-2,4,12-13H,3,5-11,14H2,(H,22,23)(H,24,25) DGXBVRBRVTWGOK-UHFFFAOYSA-N 558172 US11365192, Example 2-7 Cytochrome P450 4F2 4400 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558172&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323869 471698831 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178635 OC(=O)C1(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)CCOCC1 InChI=1S/C22H31N3O4/c26-21(27)22(11-15-28-16-12-22)10-5-3-1-2-4-6-14-29-18-7-8-19(23-17-18)20-9-13-24-25-20/h7-9,13,17H,1-6,10-12,14-16H2,(H,24,25)(H,26,27) DGHKOBYWNBOWCQ-UHFFFAOYSA-N 558173 4-[8-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]octyl]-4-oxanecarboxylic Acid::US11365192, Example 3-1 Cytochrome P450 4F2 24.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558173&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137487665 471698832 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178637 OC(=O)C1(CCCC(=O)N2CCC[C@@H](COc3ccc(nc3)-c3ccn[nH]3)C2)CCCC1 558174 US11365192, Example 3-2 Cytochrome P450 4F2 440 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558174&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323967 471698833 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178639 OC(=O)C1(CCC(=O)N2CCC(CCOc3ccc(nc3)-c3ccn[nH]3)CC2)CCCC1 InChI=1S/C24H32N4O4/c29-22(5-12-24(23(30)31)10-1-2-11-24)28-14-7-18(8-15-28)9-16-32-19-3-4-20(25-17-19)21-6-13-26-27-21/h3-4,6,13,17-18H,1-2,5,7-12,14-16H2,(H,26,27)(H,30,31) JXHJKJCKDWIJLU-UHFFFAOYSA-N 558175 US11365192, Example 3-3 Cytochrome P450 4F2 2300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558175&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323901 471698834 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178641 OC(=O)C1(CCC(=O)N2CCCC(CCOc3ccc(nc3)-c3ccn[nH]3)C2)CCCC1 558176 US11365192, Example 3-4 Cytochrome P450 4F2 260 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558176&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323922 471698835 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178643 CC(=O)N1CCC(CCCCCCOc2ccc(nc2)-c2ccn[nH]2)(CC1)C(O)=O InChI=1S/C22H30N4O4/c1-17(27)26-13-10-22(11-14-26,21(28)29)9-4-2-3-5-15-30-18-6-7-19(23-16-18)20-8-12-24-25-20/h6-8,12,16H,2-5,9-11,13-15H2,1H3,(H,24,25)(H,28,29) JXHQNUKQJGAEBX-UHFFFAOYSA-N 558177 US11365192, Example 3-5 Cytochrome P450 4F2 3000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558177&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323975 471698836 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178645 CC(=O)N1CCC(CCCCCCOc2ccc(nc2)-c2ccn[nH]2)(C1)C(O)=O 558178 US11365192, Example 3-6 Cytochrome P450 4F2 2700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558178&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323919 471698837 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178647 OC(=O)C1(CCCCCCOc2ccc(nc2)-c2ccn[nH]2)CCS(=O)(=O)CC1 InChI=1S/C20H27N3O5S/c24-19(25)20(9-13-29(26,27)14-10-20)8-3-1-2-4-12-28-16-5-6-17(21-15-16)18-7-11-22-23-18/h5-7,11,15H,1-4,8-10,12-14H2,(H,22,23)(H,24,25) OUHSVVGSMKAPDA-UHFFFAOYSA-N 558179 US11365192, Example 3-7 Cytochrome P450 4F2 5700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558179&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323933 471698838 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178649 CC(=O)N1CCC(CCCCCCCOc2ccc(nc2)-c2ccn[nH]2)(CC1)C(O)=O InChI=1S/C23H32N4O4/c1-18(28)27-14-11-23(12-15-27,22(29)30)10-5-3-2-4-6-16-31-19-7-8-20(24-17-19)21-9-13-25-26-21/h7-9,13,17H,2-6,10-12,14-16H2,1H3,(H,25,26)(H,29,30) BZLAYMPHRGUNQU-UHFFFAOYSA-N 558180 US11365192, Example 3-8 Cytochrome P450 4F2 250 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558180&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323934 471698839 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178651 OC(=O)C1(CCCC1)C(=O)NCCCCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C21H28N4O4/c26-19(21(20(27)28)10-3-4-11-21)22-12-5-1-2-6-14-29-16-7-8-17(23-15-16)18-9-13-24-25-18/h7-9,13,15H,1-6,10-12,14H2,(H,22,26)(H,24,25)(H,27,28) WUPCOABLLVWDOJ-UHFFFAOYSA-N 558181 US11365192, Example 3-9 Cytochrome P450 4F2 430 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558181&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156324038 471698840 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178653 CN(CCCCCCOc1ccc(nc1)-c1ccn[nH]1)C(=O)C1(CCCC1)C(O)=O InChI=1S/C22H30N4O4/c1-26(20(27)22(21(28)29)11-4-5-12-22)14-6-2-3-7-15-30-17-8-9-18(23-16-17)19-10-13-24-25-19/h8-10,13,16H,2-7,11-12,14-15H2,1H3,(H,24,25)(H,28,29) CGRWTZJEMVSVQX-UHFFFAOYSA-N 558182 US11365192, Example 3-10 Cytochrome P450 4F2 250 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558182&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 147219035 471698841 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178655 OCCS(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C17H17N3O4S/c21-8-9-25(22,23)15-3-1-2-13(10-15)12-24-14-4-5-16(18-11-14)17-6-7-19-20-17/h1-7,10-11,21H,8-9,12H2,(H,19,20) JBQYKSVSBLGSIW-UHFFFAOYSA-N 558183 US11365192, Example 3-11 Cytochrome P450 4F2 290 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558183&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323794 471698842 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178657 OC(=O)CCCc1cccc(CCOc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C20H21N3O3/c24-20(25)6-2-5-15-3-1-4-16(13-15)10-12-26-17-7-8-18(21-14-17)19-9-11-22-23-19/h1,3-4,7-9,11,13-14H,2,5-6,10,12H2,(H,22,23)(H,24,25) NNEAOZMKKSVHHQ-UHFFFAOYSA-N 558184 4-[3-[2-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxy]ethyl]phenyl]butanoic Acid::US11365192, Example 4-1 Cytochrome P450 4F2 830 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558184&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112510 471698843 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178659 C(Oc1ccc(nc1)-c1ccnn1C1CCCCO1)[C@@H]1CCCNC1 InChI=1S/C19H26N4O2/c1-2-11-24-19(5-1)23-18(8-10-22-23)17-7-6-16(13-21-17)25-14-15-4-3-9-20-12-15/h6-8,10,13,15,19-20H,1-5,9,11-12,14H2/t15-,19?/m1/s1 UMVQLXURFGMVSD-NYRJJRHWSA-N 558185 US11365192, Example 4-2 Cytochrome P450 4F2 160 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558185&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790562 471698844 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178661 OC(=O)c1ccc2CCC(COc3ccc(nc3)-c3ccn[nH]3)Cc2c1 558186 7-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]-5,6,7,8-tetrahydronaphthalene-2-carboxylic Acid::US11365192, Example 5-1 Cytochrome P450 4F2 33.0 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558186&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112511 471698845 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178663 OC(=O)c1ccc2CCCC(CCOc3ccc(nc3)-c3ccn[nH]3)c2c1 558187 US11365192, Example 5-2 Cytochrome P450 4F2 1700 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558187&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323920 471698846 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178665 CC(=O)N1CCC(CCCCCCCCOc2ccc(nc2)-c2ccn[nH]2)(CC1)C(O)=O InChI=1S/C24H34N4O4/c1-19(29)28-15-12-24(13-16-28,23(30)31)11-6-4-2-3-5-7-17-32-20-8-9-21(25-18-20)22-10-14-26-27-22/h8-10,14,18H,2-7,11-13,15-17H2,1H3,(H,26,27)(H,30,31) CDFRSZGNALIDGE-UHFFFAOYSA-N 558188 1-Acetyl-4-[8-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]octyl]-4-piperidinecarboxylic Acid::US11365192, Example 6-1 Cytochrome P450 4F2 7.90 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558188&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526978 471698847 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178667 CC(C)(CCOc1ccc(nc1)-c1ccn[nH]1)CCC(O)=O InChI=1S/C16H21N3O3/c1-16(2,7-5-15(20)21)8-10-22-12-3-4-13(17-11-12)14-6-9-18-19-14/h3-4,6,9,11H,5,7-8,10H2,1-2H3,(H,18,19)(H,20,21) IJYKYTRUUCTKRG-UHFFFAOYSA-N 558189 4,4-Dimethyl-6-[[6-(1H-pyrazol-5-yl)-3-pyridinyl]oxy]hexanoic Acid::US11365192, Example 7-1 Cytochrome P450 4F2 48000 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558189&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 142526800 471698848 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178669 OC(=O)[C@H]1CC[C@H](CC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558190 US11365192, Example 8-1::cis-4-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-cyclohexanecarboxylic Acid Cytochrome P450 4F2 790 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558190&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112512 471698849 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178671 OC(=O)[C@H]1CC[C@@H](CC1)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 558191 US11365192, Example 8-2::trans-4-[3-[[6-(1H-Pyrazol-5-yl)-3-pyridinyl]oxymethyl]phenyl]-1-cyclohexanecarboxylic Acid Cytochrome P450 4F2 6500 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558191&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112512 471698850 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178673 Ic1cccc(COc2ccc(nc2)-c2ccnn2C2CCCCO2)c1 InChI=1S/C20H20IN3O2/c21-16-5-3-4-15(12-16)14-26-17-7-8-18(22-13-17)19-9-10-23-24(19)20-6-1-2-11-25-20/h3-5,7-10,12-13,20H,1-2,6,11,14H2 QSLWCLSJAYNGAK-UHFFFAOYSA-N 558192 US11365192, Example 8-3 Cytochrome P450 4F2 860 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558192&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323831 471698851 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178675 OC(=O)c1ccccc1-c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C22H17N3O3/c26-22(27)19-7-2-1-6-18(19)16-5-3-4-15(12-16)14-28-17-8-9-20(23-13-17)21-10-11-24-25-21/h1-13H,14H2,(H,24,25)(H,26,27) ZRBOFKIXEBRIAE-UHFFFAOYSA-N 558193 US11365192, Example 8-4 Cytochrome P450 4F2 4300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558193&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156323978 471698852 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 1178677 CC(C)(C(O)=O)c1cccc(c1)S(=O)(=O)CCCCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C22H25N3O5S/c1-22(2,21(26)27)16-6-5-7-18(14-16)31(28,29)13-4-3-12-30-17-8-9-19(23-15-17)20-10-11-24-25-20/h5-11,14-15H,3-4,12-13H2,1-2H3,(H,24,25)(H,26,27) NMEDQBVCAPEMRM-UHFFFAOYSA-N 558194 US11365192, Example 8-5 Cytochrome P450 4F2 2300 US Patent 10.7270/Q2PN98V9 aid1806612 US11365192 Tanaka, H; Kawamura, M; Hamada, M; Kobashi, Y; Ito, Y; Suzuki, K; Bohno, A; Funayama, K TAISHO PHARMACEUTICAL CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=558194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=558194&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 165112513 471698853 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51466999 FC(F)(F)c1ccc(cc1)-c1cc(=O)c2ccccc2o1 InChI=1S/C16H9F3O2/c17-16(18,19)11-7-5-10(6-8-11)15-9-13(20)12-3-1-2-4-14(12)21-15/h1-9H XISMXQJXDBDZSJ-UHFFFAOYSA-N 50591915 CHEMBL2130955 Cytochrome P450 4F2 760 ChEMBL 10.7270/Q20P1410 35576701 Kampschulte, N; Berking, T; Çelik, IE; Kirsch, SF; Schebb, NH University of Wuppertal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591915&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 14735885 482602767 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51467000 FC(F)(F)c1ccc(cc1)-c1cc(=O)c2ccccc2o1 InChI=1S/C16H9F3O2/c17-16(18,19)11-7-5-10(6-8-11)15-9-13(20)12-3-1-2-4-14(12)21-15/h1-9H XISMXQJXDBDZSJ-UHFFFAOYSA-N 50591915 CHEMBL2130955 Cytochrome P450 4F2 870 ChEMBL 10.7270/Q20P1410 35576701 Kampschulte, N; Berking, T; Çelik, IE; Kirsch, SF; Schebb, NH University of Wuppertal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591915&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 14735885 482602767 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51467011 CC(C)[C@@H]1C[C@@H](O)[C@H]2[C@@]1(COC(C)=O)CC[C@@]1(C)[C@@H]3[C@@H](O)C[C@H]4C(C)(C)C(=O)CC[C@]4(C)C3=CC[C@]21C InChI=1S/C32H50O5/c1-18(2)21-15-23(35)27-31(8)12-9-20-26(30(31,7)13-14-32(21,27)17-37-19(3)33)22(34)16-24-28(4,5)25(36)10-11-29(20,24)6/h9,18,21-24,26-27,34-35H,10-17H2,1-8H3/t21-,22-,23+,24-,26-,27+,29+,30-,31+,32+/m0/s1 NKSVARYCVTXDAJ-DMDMSIRMSA-N 50591917 CHEBI:69527::RUBIARBONONE C::Rubiarbonone C Cytochrome P450 4F2 4200 ChEMBL 10.7270/Q20P1410 35576701 Kampschulte, N; Berking, T; Çelik, IE; Kirsch, SF; Schebb, NH University of Wuppertal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591917&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 44566786 482602769 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465974 CCOC(=O)N1CCN(CCOc2ccc(cc2)-c2ccn[nH]2)CC1 InChI=1S/C18H24N4O3/c1-2-24-18(23)22-11-9-21(10-12-22)13-14-25-16-5-3-15(4-6-16)17-7-8-19-20-17/h3-8H,2,9-14H2,1H3,(H,19,20) NSXCTRGQFUHWLE-UHFFFAOYSA-N 50591495 CHEMBL5181522 Cytochrome P450 4F2 510 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591495&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 10132265 482602347 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465975 Cc1ncsc1CCOc1ccc(cc1)-c1ccn[nH]1 InChI=1S/C15H15N3OS/c1-11-15(20-10-16-11)7-9-19-13-4-2-12(3-5-13)14-6-8-17-18-14/h2-6,8,10H,7,9H2,1H3,(H,17,18) QVEFQEQVSXFMCV-UHFFFAOYSA-N 50591496 CHEMBL5204432 Cytochrome P450 4F2 17 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591496&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 86214066 482602348 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465976 Cc1ncsc1CCOc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C14H14N4OS/c1-10-14(20-9-16-10)5-7-19-11-2-3-12(15-8-11)13-4-6-17-18-13/h2-4,6,8-9H,5,7H2,1H3,(H,17,18) CKEDYEUJOPLMES-UHFFFAOYSA-N 50591497 CHEMBL5192170 Cytochrome P450 4F2 44 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591497&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 168287902 482602349 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465977 Cc1ncsc1CCOc1cnc(nc1)-c1ccn[nH]1 InChI=1S/C13H13N5OS/c1-9-12(20-8-16-9)3-5-19-10-6-14-13(15-7-10)11-2-4-17-18-11/h2,4,6-8H,3,5H2,1H3,(H,17,18) SZXAGSIBFCEYCO-UHFFFAOYSA-N 50591498 CHEMBL5180285 Cytochrome P450 4F2 66 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591498&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 168273335 482602350 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465978 Fc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C15H12FN3O/c16-12-3-1-11(2-4-12)10-20-13-5-6-14(17-9-13)15-7-8-18-19-15/h1-9H,10H2,(H,18,19) GYFKAUWQVHEBQR-UHFFFAOYSA-N 50591499 CHEMBL5173608 Cytochrome P450 4F2 21 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591499&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790628 482602351 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465979 N#Cc1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C16H12N4O/c17-9-12-1-3-13(4-2-12)11-21-14-5-6-15(18-10-14)16-7-8-19-20-16/h1-8,10H,11H2,(H,19,20) VSFYHXIMMJUORB-UHFFFAOYSA-N 50591500 CHEMBL5195099 Cytochrome P450 4F2 6.5 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591500&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790621 482602352 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465980 N#Cc1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C16H12N4O/c17-9-12-2-1-3-13(8-12)11-21-14-4-5-15(18-10-14)16-6-7-19-20-16/h1-8,10H,11H2,(H,19,20) PBNGQRXTZDHLAJ-UHFFFAOYSA-N 50591501 CHEMBL5183418 Cytochrome P450 4F2 15 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591501&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790625 482602353 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465981 CS(=O)(=O)c1cccc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C16H15N3O3S/c1-23(20,21)14-4-2-3-12(9-14)11-22-13-5-6-15(17-10-13)16-7-8-18-19-16/h2-10H,11H2,1H3,(H,18,19) VYEWOYOKNRNSLW-UHFFFAOYSA-N 50591502 CHEMBL5205521 Cytochrome P450 4F2 260 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591502&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 130360897 482602354 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465982 CS(=O)(=O)c1ccc(COc2ccc(nc2)-c2ccn[nH]2)cc1 InChI=1S/C16H15N3O3S/c1-23(20,21)14-5-2-12(3-6-14)11-22-13-4-7-15(17-10-13)16-8-9-18-19-16/h2-10H,11H2,1H3,(H,18,19) GRNMDJLPDDZBNK-UHFFFAOYSA-N 50591503 CHEMBL5195431 Cytochrome P450 4F2 96 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591503&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790746 482602355 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465983 CS(=O)(=O)c1cc(O)cc(COc2ccc(nc2)-c2ccn[nH]2)c1 InChI=1S/C16H15N3O4S/c1-24(21,22)14-7-11(6-12(20)8-14)10-23-13-2-3-15(17-9-13)16-4-5-18-19-16/h2-9,20H,10H2,1H3,(H,18,19) MLJQFEPLHURHHC-UHFFFAOYSA-N 50591504 CHEMBL5208981 Cytochrome P450 4F2 69 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591504&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 148504929 482602356 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465984 CS(=O)(=O)N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1 50591505 CHEMBL5199278 Cytochrome P450 4F2 710 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591505&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790556 482602357 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465985 CS(=O)(=O)N1CCC[C@H](COc2ccc(nc2)-c2ccn[nH]2)C1 50591506 CHEMBL5189943 Cytochrome P450 4F2 730 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591506&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790564 482602358 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465986 CS(=O)(=O)N1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1 InChI=1S/C15H20N4O3S/c1-23(20,21)19-8-5-12(6-9-19)11-22-13-2-3-14(16-10-13)15-4-7-17-18-15/h2-4,7,10,12H,5-6,8-9,11H2,1H3,(H,17,18) WYCCWOMXNFAYQP-UHFFFAOYSA-N 50591507 CHEMBL5195609 Cytochrome P450 4F2 640 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591507&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 137364304 482602359 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465987 CC(=O)N1CCC[C@@H](COc2ccc(nc2)-c2ccn[nH]2)C1 50591508 CHEMBL5192567 Cytochrome P450 4F2 640 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591508&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790660 482602360 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465988 CC(=O)N1CCC[C@H](COc2ccc(nc2)-c2ccn[nH]2)C1 50591509 CHEMBL5191778 Cytochrome P450 4F2 180 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591509&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790580 482602361 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465989 CC(=O)N1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1 InChI=1S/C16H20N4O2/c1-12(21)20-8-5-13(6-9-20)11-22-14-2-3-15(17-10-14)16-4-7-18-19-16/h2-4,7,10,13H,5-6,8-9,11H2,1H3,(H,18,19) GNQGSUOEYQIORN-UHFFFAOYSA-N 50591510 CHEMBL5206230 Cytochrome P450 4F2 40 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591510&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 130360508 482602362 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465990 CC(=O)N1CCC(CC1)Oc1ccc(nc1)-c1ccn[nH]1 InChI=1S/C15H18N4O2/c1-11(20)19-8-5-12(6-9-19)21-13-2-3-14(16-10-13)15-4-7-17-18-15/h2-4,7,10,12H,5-6,8-9H2,1H3,(H,17,18) LSANYLYYQMSXQA-UHFFFAOYSA-N 50591511 CHEMBL5182293 Cytochrome P450 4F2 11000 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591511&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790750 482602363 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465991 CC(=O)N1CCC[C@H](C1)Oc1ccc(nc1)-c1ccn[nH]1 50591512 CHEMBL5170975 Cytochrome P450 4F2 12000 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591512&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790594 482602364 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465992 CC(=O)N1CCC[C@@H](C1)Oc1ccc(nc1)-c1ccn[nH]1 50591513 CHEMBL5181516 Cytochrome P450 4F2 >50000 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591513&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790705 482602365 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465993 CC(=O)N[C@@H]1CC[C@H](COc2ccc(nc2)-c2ccn[nH]2)CC1 50591514 CHEMBL5184859 Cytochrome P450 4F2 170 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591514&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 130360895 482602366 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465994 CC(=O)N[C@H]1CC[C@H](COc2ccc(nc2)-c2ccn[nH]2)CC1 50591515 CHEMBL5203135 Cytochrome P450 4F2 220 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591515&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 130360895 482602367 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465995 O=C(C1CC1)N1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1 InChI=1S/C18H22N4O2/c23-18(14-1-2-14)22-9-6-13(7-10-22)12-24-15-3-4-16(19-11-15)17-5-8-20-21-17/h3-5,8,11,13-14H,1-2,6-7,9-10,12H2,(H,20,21) HNIIYJYUNDTORU-UHFFFAOYSA-N 50591516 CHEMBL5199197 Cytochrome P450 4F2 110 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591516&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790650 482602368 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465996 COC(=O)N1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1 InChI=1S/C16H20N4O3/c1-22-16(21)20-8-5-12(6-9-20)11-23-13-2-3-14(17-10-13)15-4-7-18-19-15/h2-4,7,10,12H,5-6,8-9,11H2,1H3,(H,18,19) RCFOWKNJWFEKCK-UHFFFAOYSA-N 50591517 CHEMBL5183091 Cytochrome P450 4F2 73 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591517&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790698 482602369 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465997 CNC(=O)N1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1 InChI=1S/C16H21N5O2/c1-17-16(22)21-8-5-12(6-9-21)11-23-13-2-3-14(18-10-13)15-4-7-19-20-15/h2-4,7,10,12H,5-6,8-9,11H2,1H3,(H,17,22)(H,19,20) XVWAKURISNTVLU-UHFFFAOYSA-N 50591518 CHEMBL5172100 Cytochrome P450 4F2 63 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591518&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 156061386 482602370 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465998 CN(C)C(=O)N1CCC(COc2ccc(nc2)-c2ccn[nH]2)CC1 InChI=1S/C17H23N5O2/c1-21(2)17(23)22-9-6-13(7-10-22)12-24-14-3-4-15(18-11-14)16-5-8-19-20-16/h3-5,8,11,13H,6-7,9-10,12H2,1-2H3,(H,19,20) TVGCTSKJDQPBNN-UHFFFAOYSA-N 50591519 CHEMBL5174407 Cytochrome P450 4F2 19 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591519&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 130360892 482602371 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8 51465999 CN(C)S(=O)(=O)N1CCC[C@H](COc2ccc(nc2)-c2ccn[nH]2)C1 50591520 CHEMBL5169535 Cytochrome P450 4F2 36 ChEMBL 10.7270/Q2MK6HW6 36318660 Kawamura, M; Kobashi, Y; Tanaka, H; Bohno-Mikami, A; Hamada, M; Ito, Y; Hirata, T; Ohara, H; Kojima, N; Koretsune, H; Gunji, E; Fukunaga, T; Inatani, S; Hasegawa, Y; Suzuki, A; Takahashi, T; Kakinuma, H Taisho Pharmaceutical Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50591520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006874&target=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50591520&enzyme=Cytochrome+P450+4F2&column=ki&startPg=0&Increment=50&submit=Search 155790733 482602372 1 MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS Cytochrome P450 4F2 CP4F2_HUMAN P78329 A0A024R7K3 A8K425 B4DV75 Q16677 Q6NWT4 Q6NWT6 Q9NNZ0 Q9UIU8