BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50109125 COc1cccc(-c2cc(C)c(s2)C(=O)N(C)Cc2cccc(O)c2)c1F InChI=1S/C21H20FNO3S/c1-13-10-18(16-8-5-9-17(26-3)19(16)22)27-20(13)21(25)23(2)12-14-6-4-7-15(24)11-14/h4-11,24H,12H2,1-3H3 JVVLBENNFHXWCI-UHFFFAOYSA-N 50021404 CHEMBL3289873 Estradiol 17-beta-dehydrogenase 2 54 ChEMBL 10.1016/j.ejmech.2014.06.036 10.7270/Q2HQ41H5 24974351 Perspicace, E; Cozzoli, L; Gargano, EM; Hanke, N; Carotti, A; Hartmann, RW; Marchais-Oberwinkler, S Saarland University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50021404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50021404&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 90645097 103932108 CHEMBL3289873 ZINC29231329 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 50427078 Oc1ccc(F)c(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3C(F)(F)F)c2)c1F InChI=1S/C24H14F5NO4S2/c25-16-8-9-17(31)22(26)21(16)23(32)19-11-10-18(35-19)13-4-3-5-14(12-13)30-36(33,34)20-7-2-1-6-15(20)24(27,28)29/h1-12,30-31H XPRMXEDUCYZGTN-UHFFFAOYSA-N 50126973 CHEMBL3629587 Estradiol 17-beta-dehydrogenase 2 20 ChEMBL 10.1016/j.ejmech.2015.08.030 10.7270/Q22V2HXX 26322835 Abdelsamie, AS; Bey, E; Gargano, EM; van Koppen, CJ; Empting, M; Frotscher, M Saarland University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126973&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122194412 321902449 CHEMBL3629587 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 50427085 Cc1cc(NS(=O)(=O)C2CC2)cc(c1)-c1ccc(s1)C(=O)c1c(F)ccc(O)c1F InChI=1S/C21H17F2NO4S2/c1-11-8-12(10-13(9-11)24-30(27,28)14-2-3-14)17-6-7-18(29-17)21(26)19-15(22)4-5-16(25)20(19)23/h4-10,14,24-25H,2-3H2,1H3 ARYRCGSUJZWHTF-UHFFFAOYSA-N 50126977 CHEMBL3629591 Estradiol 17-beta-dehydrogenase 2 55 ChEMBL 10.1016/j.ejmech.2015.08.030 10.7270/Q22V2HXX 26322835 Abdelsamie, AS; Bey, E; Gargano, EM; van Koppen, CJ; Empting, M; Frotscher, M Saarland University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126977&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122194416 321902453 CHEMBL3629591 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 50427089 CN(c1cc(C)cc(c1)-c1ccc(s1)C(=O)c1c(F)ccc(O)c1F)S(=O)(=O)C1CC1 InChI=1S/C22H19F2NO4S2/c1-12-9-13(11-14(10-12)25(2)31(28,29)15-3-4-15)18-7-8-19(30-18)22(27)20-16(23)5-6-17(26)21(20)24/h5-11,15,26H,3-4H2,1-2H3 HXDPJZZZCAYSRL-UHFFFAOYSA-N 50126978 CHEMBL3629592 Estradiol 17-beta-dehydrogenase 2 129 ChEMBL 10.1016/j.ejmech.2015.08.030 10.7270/Q22V2HXX 26322835 Abdelsamie, AS; Bey, E; Gargano, EM; van Koppen, CJ; Empting, M; Frotscher, M Saarland University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126978&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122194417 321902454 CHEMBL3629592 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51136497 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3OC(F)(F)F)c2)c1F InChI=1S/C24H13F6NO5S2/c25-15-11-14(20(26)23(33)21(15)27)22(32)18-9-8-17(37-18)12-4-3-5-13(10-12)31-38(34,35)19-7-2-1-6-16(19)36-24(28,29)30/h1-11,31,33H RKOXKEAQCMCSPB-UHFFFAOYSA-N 50466002 CHEMBL4285743 Estradiol 17-beta-dehydrogenase 2 25 ChEMBL 10.1021/acs.jmedchem.8b01373 10.7270/Q2708448 30480443 Siebenbuerger, L; Hernandez-Olmos, V; Abdelsamie, AS; Frotscher, M; van Koppen, CJ; Marchais-Oberwinkler, S; Scheuer, C; Laschke, MW; Menger, MD; Boerger, C; Hartmann, RW PharmBioTec GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466002&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122652951 433933267 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51136554 COc1c(Cl)cc(cc1Cl)-c1ccc(s1)C(=O)c1cc(F)c(F)c(O)c1F InChI=1S/C18H9Cl2F3O3S/c1-26-18-9(19)4-7(5-10(18)20)12-2-3-13(27-12)16(24)8-6-11(21)15(23)17(25)14(8)22/h2-6,25H,1H3 UTTSXHQNYXLHAR-UHFFFAOYSA-N 50466018 CHEMBL4283851 Estradiol 17-beta-dehydrogenase 2 89 ChEMBL 10.1021/acs.jmedchem.8b01373 10.7270/Q2708448 30480443 Siebenbuerger, L; Hernandez-Olmos, V; Abdelsamie, AS; Frotscher, M; van Koppen, CJ; Marchais-Oberwinkler, S; Scheuer, C; Laschke, MW; Menger, MD; Boerger, C; Hartmann, RW PharmBioTec GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466018&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122652898 433933283 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51136555 Cc1cc(cc(C)c1O)-c1ccc(s1)C(=O)c1cc(F)c(F)c(O)c1F InChI=1S/C19H13F3O3S/c1-8-5-10(6-9(2)17(8)23)13-3-4-14(26-13)18(24)11-7-12(20)16(22)19(25)15(11)21/h3-7,23,25H,1-2H3 BVLIRXILWDNARH-UHFFFAOYSA-N 50466019 CHEMBL4286251 Estradiol 17-beta-dehydrogenase 2 58 ChEMBL 10.1021/acs.jmedchem.8b01373 10.7270/Q2708448 30480443 Siebenbuerger, L; Hernandez-Olmos, V; Abdelsamie, AS; Frotscher, M; van Koppen, CJ; Marchais-Oberwinkler, S; Scheuer, C; Laschke, MW; Menger, MD; Boerger, C; Hartmann, RW PharmBioTec GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466019&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122652933 433933284 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51136556 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc3[nH]ccc23)c1F InChI=1S/C19H10F3NO2S/c20-12-8-11(16(21)19(25)17(12)22)18(24)15-5-4-14(26-15)10-2-1-3-13-9(10)6-7-23-13/h1-8,23,25H JHOCMAGGDWVVGZ-UHFFFAOYSA-N 50466012 CHEMBL4287575 Estradiol 17-beta-dehydrogenase 2 34 ChEMBL 10.1021/acs.jmedchem.8b01373 10.7270/Q2708448 30480443 Siebenbuerger, L; Hernandez-Olmos, V; Abdelsamie, AS; Frotscher, M; van Koppen, CJ; Marchais-Oberwinkler, S; Scheuer, C; Laschke, MW; Menger, MD; Boerger, C; Hartmann, RW PharmBioTec GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466012&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122653016 433933277 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51136570 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccc3[nH]ccc3c2)c1F InChI=1S/C19H10F3NO2S/c20-12-8-11(16(21)19(25)17(12)22)18(24)15-4-3-14(26-15)10-1-2-13-9(7-10)5-6-23-13/h1-8,23,25H PDZDSJHULKVPPZ-UHFFFAOYSA-N 50466027 CHEMBL4292910 Estradiol 17-beta-dehydrogenase 2 34 ChEMBL 10.1021/acs.jmedchem.8b01373 10.7270/Q2708448 30480443 Siebenbuerger, L; Hernandez-Olmos, V; Abdelsamie, AS; Frotscher, M; van Koppen, CJ; Marchais-Oberwinkler, S; Scheuer, C; Laschke, MW; Menger, MD; Boerger, C; Hartmann, RW PharmBioTec GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466027&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122652969 433933292 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261565 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3OC(F)(F)F)c2)c1F InChI=1S/C24H13F6NO5S2/c25-15-11-14(20(26)23(33)21(15)27)22(32)18-9-8-17(37-18)12-4-3-5-13(10-12)31-38(34,35)19-7-2-1-6-16(19)36-24(28,29)30/h1-11,31,33H RKOXKEAQCMCSPB-UHFFFAOYSA-N 50466002 CHEMBL4285743 Estradiol 17-beta-dehydrogenase 2 25 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466002&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122652951 433933267 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261568 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccc(cc3)C#N)c2)c1F InChI=1S/C24H13F3N2O4S2/c25-18-11-17(21(26)24(31)22(18)27)23(30)20-9-8-19(34-20)14-2-1-3-15(10-14)29-35(32,33)16-6-4-13(12-28)5-7-16/h1-11,29,31H KHIRYSLWKHQOIK-UHFFFAOYSA-N 50515432 CHEMBL4447938 Estradiol 17-beta-dehydrogenase 2 25 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515432&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155519849 440724014 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261571 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccccc2NS(=O)(=O)c2ccc(Cl)nc2)c1F InChI=1S/C22H12ClF3N2O4S2/c23-18-8-5-11(10-27-18)34(31,32)28-15-4-2-1-3-12(15)16-6-7-17(33-16)21(29)13-9-14(24)20(26)22(30)19(13)25/h1-10,28,30H ZDKXTKFNOBVVDR-UHFFFAOYSA-N 50515436 CHEMBL4441313 Estradiol 17-beta-dehydrogenase 2 46 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515436&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155515127 440724018 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261606 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccc(Cl)nc3)c2)c1F InChI=1S/C22H12ClF3N2O4S2/c23-18-7-4-13(10-27-18)34(31,32)28-12-3-1-2-11(8-12)16-5-6-17(33-16)21(29)14-9-15(24)20(26)22(30)19(14)25/h1-10,28,30H OECSXGBSPYORAG-UHFFFAOYSA-N 50515437 CHEMBL4471724 Estradiol 17-beta-dehydrogenase 2 47 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515437&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155535276 440724019 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261607 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3cccc(c3)C#N)c2)c1F InChI=1S/C24H13F3N2O4S2/c25-18-11-17(21(26)24(31)22(18)27)23(30)20-8-7-19(34-20)14-4-2-5-15(10-14)29-35(32,33)16-6-1-3-13(9-16)12-28/h1-11,29,31H MOSDGHOILUMKDT-UHFFFAOYSA-N 50515448 CHEMBL4459275 Estradiol 17-beta-dehydrogenase 2 15 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515448&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155527207 440724030 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261608 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3C#N)c2)c1F InChI=1S/C24H13F3N2O4S2/c25-17-11-16(21(26)24(31)22(17)27)23(30)19-9-8-18(34-19)13-5-3-6-15(10-13)29-35(32,33)20-7-2-1-4-14(20)12-28/h1-11,29,31H SLTPDYPQXHBOFF-UHFFFAOYSA-N 50515441 CHEMBL4466918 Estradiol 17-beta-dehydrogenase 2 28 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515441&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155531966 440724023 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261609 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccccc2NS(=O)(=O)c2ccc(F)cc2)c1F InChI=1S/C23H13F4NO4S2/c24-12-5-7-13(8-6-12)34(31,32)28-17-4-2-1-3-14(17)18-9-10-19(33-18)22(29)15-11-16(25)21(27)23(30)20(15)26/h1-11,28,30H CHVVDDGGNOHSOG-UHFFFAOYSA-N 50515434 CHEMBL4518587 Estradiol 17-beta-dehydrogenase 2 22 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515434&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 139030522 440724016 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261610 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cc(NS(=O)(=O)c3ccc(Cl)nc3)c(F)cc2F)c1F InChI=1S/C22H10ClF5N2O4S2/c23-18-4-1-9(8-29-18)36(33,34)30-15-6-10(12(24)7-13(15)25)16-2-3-17(35-16)21(31)11-5-14(26)20(28)22(32)19(11)27/h1-8,30,32H JKHGXFOISOLZKF-UHFFFAOYSA-N 50515451 CHEMBL4584616 Estradiol 17-beta-dehydrogenase 2 60 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515451&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155562009 440724033 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261611 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccc(NS(=O)(=O)c3ccc(cc3)C#N)cc2)c1F InChI=1S/C24H13F3N2O4S2/c25-18-11-17(21(26)24(31)22(18)27)23(30)20-10-9-19(34-20)14-3-5-15(6-4-14)29-35(32,33)16-7-1-13(12-28)2-8-16/h1-11,29,31H JXUNVJWFIFYSLS-UHFFFAOYSA-N 50515431 CHEMBL4441357 Estradiol 17-beta-dehydrogenase 2 30 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515431&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155514963 440724013 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261614 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccccc2NS(=O)(=O)c2ccc(cc2)C#N)c1F InChI=1S/C24H13F3N2O4S2/c25-17-11-16(21(26)24(31)22(17)27)23(30)20-10-9-19(34-20)15-3-1-2-4-18(15)29-35(32,33)14-7-5-13(12-28)6-8-14/h1-11,29,31H HSZRZXUTUZZOTH-UHFFFAOYSA-N 50515450 CHEMBL4443361 Estradiol 17-beta-dehydrogenase 2 57 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515450&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155516583 440724032 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261617 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cc(NS(=O)(=O)c3ccc(F)cc3)c(F)cc2F)c1F InChI=1S/C23H11F6NO4S2/c24-10-1-3-11(4-2-10)36(33,34)30-17-8-12(14(25)9-15(17)26)18-5-6-19(35-18)22(31)13-7-16(27)21(29)23(32)20(13)28/h1-9,30,32H HNXVLHDEEPNFTM-UHFFFAOYSA-N 50515435 CHEMBL4513439 Estradiol 17-beta-dehydrogenase 2 32 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515435&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155538884 440724017 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261622 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccc(NS(=O)(=O)c3ccc(Cl)nc3)cc2)c1F InChI=1S/C22H12ClF3N2O4S2/c23-18-8-5-13(10-27-18)34(31,32)28-12-3-1-11(2-4-12)16-6-7-17(33-16)21(29)14-9-15(24)20(26)22(30)19(14)25/h1-10,28,30H FBJGDDQSQUOPNR-UHFFFAOYSA-N 50515445 CHEMBL4453509 Estradiol 17-beta-dehydrogenase 2 44 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515445&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155523432 440724027 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261632 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccc(F)cc3)c2)c1F InChI=1S/C23H13F4NO4S2/c24-13-4-6-15(7-5-13)34(31,32)28-14-3-1-2-12(10-14)18-8-9-19(33-18)22(29)16-11-17(25)21(27)23(30)20(16)26/h1-11,28,30H BKLGSTICODUCKD-UHFFFAOYSA-N 50515446 CHEMBL4441152 Estradiol 17-beta-dehydrogenase 2 27 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515446&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155515038 440724028 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261633 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccc(NS(=O)(=O)c3ccc(F)cc3)cc2)c1F InChI=1S/C23H13F4NO4S2/c24-13-3-7-15(8-4-13)34(31,32)28-14-5-1-12(2-6-14)18-9-10-19(33-18)22(29)16-11-17(25)21(27)23(30)20(16)26/h1-11,28,30H QUBHXZCKRNUSHH-UHFFFAOYSA-N 50515444 CHEMBL4462505 Estradiol 17-beta-dehydrogenase 2 15 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515444&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155529123 440724026 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51261634 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cc(NS(=O)(=O)c3ccc(cc3)C#N)c(F)cc2F)c1F InChI=1S/C24H11F5N2O4S2/c25-15-9-16(26)18(31-37(34,35)12-3-1-11(10-30)2-4-12)8-13(15)19-5-6-20(36-19)23(32)14-7-17(27)22(29)24(33)21(14)28/h1-9,31,33H NOGBQLBZUQQSFJ-UHFFFAOYSA-N 50515449 CHEMBL4470668 Estradiol 17-beta-dehydrogenase 2 50 ChEMBL 10.1021/acs.jmedchem.9b00932 10.7270/Q27H1NX9 31343176 Abdelsamie, AS; Salah, M; Siebenbürger, L; Merabet, A; Scheuer, C; Frotscher, M; Müller, ST; Zierau, O; Vollmer, G; Menger, MD; Laschke, MW; van Koppen, CJ; Marchais-Oberwinkler, S; Hartmann, RW ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515449&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155534601 440724031 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51263673 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3OC(F)(F)F)c2)c1F InChI=1S/C24H13F6NO5S2/c25-15-11-14(20(26)23(33)21(15)27)22(32)18-9-8-17(37-18)12-4-3-5-13(10-12)31-38(34,35)19-7-2-1-6-16(19)36-24(28,29)30/h1-11,31,33H RKOXKEAQCMCSPB-UHFFFAOYSA-N 50466002 CHEMBL4285743 Estradiol 17-beta-dehydrogenase 2 25 ChEMBL 10.1016/j.ejmech.2019.05.084 10.7270/Q2NC64JD 31176098 Abdelsamie, AS; Salah, M; Siebenbürger, L; Hamed, MM; Börger, C; van Koppen, CJ; Frotscher, M; Hartmann, RW Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466002&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122652951 433933267 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51263691 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc3[nH]ccc23)c1F InChI=1S/C19H10F3NO2S/c20-12-8-11(16(21)19(25)17(12)22)18(24)15-5-4-14(26-15)10-2-1-3-13-9(10)6-7-23-13/h1-8,23,25H JHOCMAGGDWVVGZ-UHFFFAOYSA-N 50466012 CHEMBL4287575 Estradiol 17-beta-dehydrogenase 2 34 ChEMBL 10.1016/j.ejmech.2019.05.084 10.7270/Q2NC64JD 31176098 Abdelsamie, AS; Salah, M; Siebenbürger, L; Hamed, MM; Börger, C; van Koppen, CJ; Frotscher, M; Hartmann, RW Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466012&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122653016 433933277 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51263702 NS(=O)(=O)Oc1ccc(cc1)-c1ccc(s1)C(=O)c1cc(F)c(F)c(O)c1F InChI=1S/C17H10F3NO5S2/c18-11-7-10(14(19)17(23)15(11)20)16(22)13-6-5-12(27-13)8-1-3-9(4-2-8)26-28(21,24)25/h1-7,23H,(H2,21,24,25) VEOHVGGIOZDGJG-UHFFFAOYSA-N 50516198 CHEMBL4584367 Estradiol 17-beta-dehydrogenase 2 80 ChEMBL 10.1016/j.ejmech.2019.05.084 10.7270/Q2NC64JD 31176098 Abdelsamie, AS; Salah, M; Siebenbürger, L; Hamed, MM; Börger, C; van Koppen, CJ; Frotscher, M; Hartmann, RW Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50516198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50516198&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122653046 440724780 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290296 Oc1cc(ccc1Cl)C(=O)c1ccc(s1)-c1cccc(NS(=O)(=O)c2ccccc2)c1 InChI=1S/C23H16ClNO4S2/c24-19-10-9-16(14-20(19)26)23(27)22-12-11-21(30-22)15-5-4-6-17(13-15)25-31(28,29)18-7-2-1-3-8-18/h1-14,25-26H PJWQHMPSYVIIQW-UHFFFAOYSA-N 50525965 CHEMBL4519897 Estradiol 17-beta-dehydrogenase 2 304 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525965&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155542289 440734547 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290297 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3C(F)(F)F)c2)c1F InChI=1S/C24H13F6NO4S2/c25-16-11-14(20(26)23(33)21(16)27)22(32)18-9-8-17(36-18)12-4-3-5-13(10-12)31-37(34,35)19-7-2-1-6-15(19)24(28,29)30/h1-11,31,33H MMECSDRIPCDVPA-UHFFFAOYSA-N 50525966 CHEMBL4552641 Estradiol 17-beta-dehydrogenase 2 12 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525966&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122652990 440734548 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290316 Oc1cccc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3)c2)c1F InChI=1S/C23H16FNO4S2/c24-22-18(10-5-11-19(22)26)23(27)21-13-12-20(30-21)15-6-4-7-16(14-15)25-31(28,29)17-8-2-1-3-9-17/h1-14,25-26H XBXQTLCZHDQCKE-UHFFFAOYSA-N 50525973 CHEMBL4461477 Estradiol 17-beta-dehydrogenase 2 82 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525973&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155528716 440734555 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290317 Oc1ccc(F)c(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3)c2)c1F InChI=1S/C23H15F2NO4S2/c24-17-9-10-18(27)22(25)21(17)23(28)20-12-11-19(31-20)14-5-4-6-15(13-14)26-32(29,30)16-7-2-1-3-8-16/h1-13,26-27H RJKVDZCQKDOADU-UHFFFAOYSA-N 50525963 CHEMBL4582194 Estradiol 17-beta-dehydrogenase 2 31 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525963&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155562215 440734545 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290318 Oc1ccc(Cl)c(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3)c2)c1F InChI=1S/C23H15ClFNO4S2/c24-17-9-10-18(27)22(25)21(17)23(28)20-12-11-19(31-20)14-5-4-6-15(13-14)26-32(29,30)16-7-2-1-3-8-16/h1-13,26-27H FFPPYOWUSBRLMV-UHFFFAOYSA-N 50525967 CHEMBL4538007 Estradiol 17-beta-dehydrogenase 2 8.9 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525967&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155548975 440734549 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290319 Oc1ccc(F)c(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3)c2)c1Cl InChI=1S/C23H15ClFNO4S2/c24-22-18(27)10-9-17(25)21(22)23(28)20-12-11-19(31-20)14-5-4-6-15(13-14)26-32(29,30)16-7-2-1-3-8-16/h1-13,26-27H XSBGMNVHRLMVIZ-UHFFFAOYSA-N 50525972 CHEMBL4459887 Estradiol 17-beta-dehydrogenase 2 2.7 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525972&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155527324 440734554 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290320 Cc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)-c1ccc(s1)C(=O)c1cc(F)c(F)c(O)c1F InChI=1S/C24H16F3NO4S2/c1-13-5-7-16(8-6-13)34(31,32)28-15-4-2-3-14(11-15)19-9-10-20(33-19)23(29)17-12-18(25)22(27)24(30)21(17)26/h2-12,28,30H,1H3 XDBFOIZCTXHZMT-UHFFFAOYSA-N 50525968 CHEMBL4457145 Estradiol 17-beta-dehydrogenase 2 9.9 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525968&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155526302 440734550 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290321 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3OC(F)(F)F)c2)c1F InChI=1S/C24H13F6NO5S2/c25-15-11-14(20(26)23(33)21(15)27)22(32)18-9-8-17(37-18)12-4-3-5-13(10-12)31-38(34,35)19-7-2-1-6-16(19)36-24(28,29)30/h1-11,31,33H RKOXKEAQCMCSPB-UHFFFAOYSA-N 50466002 CHEMBL4285743 Estradiol 17-beta-dehydrogenase 2 25 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466002&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122652951 433933267 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290322 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)c2)c1F InChI=1S/C24H12BrF6NO5S2/c25-12-4-7-19(16(9-12)37-24(29,30)31)39(35,36)32-13-3-1-2-11(8-13)17-5-6-18(38-17)22(33)14-10-15(26)21(28)23(34)20(14)27/h1-10,32,34H WHHDACZXNMFBDX-UHFFFAOYSA-N 50525970 CHEMBL4450585 Estradiol 17-beta-dehydrogenase 2 14 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525970&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 122653011 440734552 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290323 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccc(Cl)cc3)c2)c1F InChI=1S/C23H13ClF3NO4S2/c24-13-4-6-15(7-5-13)34(31,32)28-14-3-1-2-12(10-14)18-8-9-19(33-18)22(29)16-11-17(25)21(27)23(30)20(16)26/h1-11,28,30H CSGXUMJCTCEVTD-UHFFFAOYSA-N 50525964 CHEMBL4546082 Estradiol 17-beta-dehydrogenase 2 6.2 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525964&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155553373 440734546 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290324 Cc1cccc(c1)S(=O)(=O)Nc1cccc(c1)-c1ccc(s1)C(=O)c1cc(F)c(F)c(O)c1F InChI=1S/C24H16F3NO4S2/c1-13-4-2-7-16(10-13)34(31,32)28-15-6-3-5-14(11-15)19-8-9-20(33-19)23(29)17-12-18(25)22(27)24(30)21(17)26/h2-12,28,30H,1H3 CXWWNZPMIDOSAZ-UHFFFAOYSA-N 50525969 CHEMBL4529443 Estradiol 17-beta-dehydrogenase 2 7.9 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525969&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155545568 440734551 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290335 Oc1cccc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3)c2)c1Cl InChI=1S/C23H16ClNO4S2/c24-22-18(10-5-11-19(22)26)23(27)21-13-12-20(30-21)15-6-4-7-16(14-15)25-31(28,29)17-8-2-1-3-9-17/h1-14,25-26H BYONQZJFCLEVGK-UHFFFAOYSA-N 50525971 CHEMBL4574253 Estradiol 17-beta-dehydrogenase 2 2.7 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525971&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155564096 440734553 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290336 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccc(F)cc3)c2)c1F InChI=1S/C23H13F4NO4S2/c24-13-4-6-15(7-5-13)34(31,32)28-14-3-1-2-12(10-14)18-8-9-19(33-18)22(29)16-11-17(25)21(27)23(30)20(16)26/h1-11,28,30H BKLGSTICODUCKD-UHFFFAOYSA-N 50515446 CHEMBL4441152 Estradiol 17-beta-dehydrogenase 2 27 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50515446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50515446&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155515038 440724028 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898 51290337 Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3cccc(Cl)c3)c2)c1F InChI=1S/C23H13ClF3NO4S2/c24-13-4-2-6-15(10-13)34(31,32)28-14-5-1-3-12(9-14)18-7-8-19(33-18)22(29)16-11-17(25)21(27)23(30)20(16)26/h1-11,28,30H IYBQWTNWWLAKNU-UHFFFAOYSA-N 50525962 CHEMBL4464314 Estradiol 17-beta-dehydrogenase 2 5.6 ChEMBL 10.1021/acs.jmedchem.8b01493 10.7270/Q2CR5XS0 30645111 Abdelsamie, AS; Herath, S; Biskupek, Y; Börger, C; Siebenbürger, L; Salah, M; Scheuer, C; Marchais-Oberwinkler, S; Frotscher, M; Pohlemann, T; Menger, MD; Hartmann, RW; Laschke, MW; van Koppen, CJ ElexoPharm GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50525962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006640&target=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50525962&enzyme=Estradiol+17-beta-dehydrogenase+2&column=ki&startPg=0&Increment=50&submit=Search 155530633 440734544 1 MSPFASESAWLCLAAAAVLGGTLLCGCRSGRQLRSQAVCLAGLWGGACLLSLSLLCTLFLLSVACFLLLYMSSSDQDLLPVDQKAVLVTGADSGFGHGLAKHLDKLGFTVFAGVLDKEGPGAEELRKHCSERLSVLQMDVTKPEQIKDAHSKVTEKIQDKGLWAVVNNAGVFHLPIDGELIPMSIYRKCMAVNFFGTVEVTKAFLPLLRKSKGRLVNVSSMGGTVPLQMTSAYAATKAALTMFSTIIRQELDKWGVKVVTIKPGGFKTNITGSQDIWDKMEKEILDHFSKDIQENYGQDYVHTQKLIIPTLKERSNPDITPVLRDIQHAISARNPSSFYYPGRMAYLWVCLAAYCPTSLLDYVIKKGFYPQPTPRALRTVH Estradiol 17-beta-dehydrogenase 2 DHB2_MOUSE P51658 O08898