BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50265778 CCN(CC)c1cc(ccc1N(C)C(=O)c1c(F)cccc1Cl)-c1cc(ccc1Cl)C(=O)NCC(C)(C)O InChI=1S/C29H32Cl2FN3O3/c1-6-35(7-2)25-16-18(20-15-19(11-13-21(20)30)27(36)33-17-29(3,4)38)12-14-24(25)34(5)28(37)26-22(31)9-8-10-23(26)32/h8-16,38H,6-7,17H2,1-5H3,(H,33,36) DOHADTWEKGOQTE-UHFFFAOYSA-N 50044245 CHEMBL3314043 Nuclear receptor ROR-gamma Mus musculus <100 ChEMBL 10.1021/jm401901d 10.7270/Q2M0473Z 24502334 Fauber, BP; Magnuson, S Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044245&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118753645 313068141 CHEMBL3314043 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50265779 CN(C(=O)c1c(F)cccc1Cl)c1ccc(cc1O[C@@H]1C[C@@H]2C[C@@H]2C1)-c1cc(ccc1Cl)C(N)=O InChI=1S/C27H23Cl2FN2O3/c1-32(27(34)25-21(29)3-2-4-22(25)30)23-8-6-14(19-12-15(26(31)33)5-7-20(19)28)13-24(23)35-18-10-16-9-17(16)11-18/h2-8,12-13,16-18H,9-11H2,1H3,(H2,31,33)/t16-,17+,18+ DUIXDTSBHJPLIP-PIIMJCKOSA-N 50044246 CHEMBL3314042 Nuclear receptor ROR-gamma Mus musculus <100 ChEMBL 10.1021/jm401901d 10.7270/Q2M0473Z 24502334 Fauber, BP; Magnuson, S Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044246&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 90078028 313068142 CHEMBL3314042 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50265780 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(Cl)cc4Cl)ccc3c2)cc1 InChI=1S/C26H24Cl2N2O3S/c1-2-34(32,33)23-8-3-18(4-9-23)15-26(31)29-22-7-10-25-20(16-22)12-14-30(25)13-11-19-5-6-21(27)17-24(19)28/h3-10,12,14,16-17H,2,11,13,15H2,1H3,(H,29,31) WIBNEZIGZFNPGQ-UHFFFAOYSA-N 50446283 CHEMBL3109235 Nuclear receptor ROR-gamma Mus musculus 9.0 ChEMBL 10.1021/jm401901d 10.7270/Q2M0473Z 24502334 Fauber, BP; Magnuson, S Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446283&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73671285 194944179 CHEMBL3109235 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50265781 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2Cl)-c2cccc(Cl)c2)cc1 InChI=1S/C26H20Cl2N2O4S2/c1-2-36(33,34)19-12-10-16(11-13-19)14-22(31)29-26-30-23(17-6-5-7-18(27)15-17)25(35-26)24(32)20-8-3-4-9-21(20)28/h3-13,15H,2,14H2,1H3,(H,29,30,31) GRWNPFJXINLSNF-UHFFFAOYSA-N 50445877 CHEMBL3105681 Nuclear receptor ROR-gamma Mus musculus 158 ChEMBL 10.1021/jm401901d 10.7270/Q2M0473Z 24502334 Fauber, BP; Magnuson, S Genentech http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445877&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 8YB 5NU1,5NI5 56837193 194943773 CHEMBL3105681 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394201 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccccc3Cl)s2)-c2ccccc2)cc1 InChI=1S/C25H21ClN2O4S2/c1-2-34(30,31)19-14-12-17(13-15-19)16-22(29)27-25-28-23(18-8-4-3-5-9-18)24(33-25)32-21-11-7-6-10-20(21)26/h3-15H,2,16H2,1H3,(H,27,28,29) NAVOGDSNKJXUPD-UHFFFAOYSA-N 50111584 CHEMBL3605081 Nuclear receptor ROR-gamma Mus musculus 1585 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111584&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 60142606 319493458 CHEMBL3605081 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394228 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccccc3C(F)(F)F)s2)-c2ccccc2)cc1 InChI=1S/C26H21F3N2O4S2/c1-2-37(33,34)19-14-12-17(13-15-19)16-22(32)30-25-31-23(18-8-4-3-5-9-18)24(36-25)35-21-11-7-6-10-20(21)26(27,28)29/h3-15H,2,16H2,1H3,(H,30,31,32) XIHPSSVWDAHNAW-UHFFFAOYSA-N 50111588 CHEMBL3605082 Nuclear receptor ROR-gamma Mus musculus 1000 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111588&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 60142739 104006126 CHEMBL3605082 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394231 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccccc3OC)s2)-c2ccccc2)cc1 InChI=1S/C26H24N2O5S2/c1-3-35(30,31)20-15-13-18(14-16-20)17-23(29)27-26-28-24(19-9-5-4-6-10-19)25(34-26)33-22-12-8-7-11-21(22)32-2/h4-16H,3,17H2,1-2H3,(H,27,28,29) UPGARTDUWSLIEB-UHFFFAOYSA-N 50111599 CHEMBL3605083 Nuclear receptor ROR-gamma Mus musculus 251 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111599&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122186248 104006137 CHEMBL3605083 ZINC34369088 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394233 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccc(Cl)cc3)s2)-c2ccccc2)cc1 InChI=1S/C25H21ClN2O4S2/c1-2-34(30,31)21-14-8-17(9-15-21)16-22(29)27-25-28-23(18-6-4-3-5-7-18)24(33-25)32-20-12-10-19(26)11-13-20/h3-15H,2,16H2,1H3,(H,27,28,29) IRLSEBVESJQRHW-UHFFFAOYSA-N 50111601 CHEMBL3605084 Nuclear receptor ROR-gamma Mus musculus 1585 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111601&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 57521299 104006139 CHEMBL3605084 ZINC12405071 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394241 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccc(cc3)C(F)(F)F)s2)-c2ccccc2)cc1 InChI=1S/C26H21F3N2O4S2/c1-2-37(33,34)21-14-8-17(9-15-21)16-22(32)30-25-31-23(18-6-4-3-5-7-18)24(36-25)35-20-12-10-19(11-13-20)26(27,28)29/h3-15H,2,16H2,1H3,(H,30,31,32) NJKMVQWLGFNJMI-UHFFFAOYSA-N 50111602 CHEMBL3605085 Nuclear receptor ROR-gamma Mus musculus 631 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111602&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 60142742 104006140 CHEMBL3605085 ZINC04521479 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394245 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccc(OC)cc3)s2)-c2ccccc2)cc1 InChI=1S/C26H24N2O5S2/c1-3-35(30,31)22-15-9-18(10-16-22)17-23(29)27-26-28-24(19-7-5-4-6-8-19)25(34-26)33-21-13-11-20(32-2)12-14-21/h4-16H,3,17H2,1-2H3,(H,27,28,29) ANHCIPXNRMCIMG-UHFFFAOYSA-N 50111610 CHEMBL3605086 Nuclear receptor ROR-gamma Mus musculus <10000 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111610&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 60142867 104006148 CHEMBL3605086 ZINC35982152 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394246 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccccc3)s2)-c2ccc(Cl)cc2)cc1 InChI=1S/C25H21ClN2O4S2/c1-2-34(30,31)21-14-8-17(9-15-21)16-22(29)27-25-28-23(18-10-12-19(26)13-11-18)24(33-25)32-20-6-4-3-5-7-20/h3-15H,2,16H2,1H3,(H,27,28,29) IIKOUMCUMDNGMU-UHFFFAOYSA-N 50111677 CHEMBL3605087 Nuclear receptor ROR-gamma Mus musculus 3981 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111677&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 60142604 319493459 CHEMBL3605087 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394247 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccccc3)s2)-c2cccc(Cl)c2)cc1 InChI=1S/C25H21ClN2O4S2/c1-2-34(30,31)21-13-11-17(12-14-21)15-22(29)27-25-28-23(18-7-6-8-19(26)16-18)24(33-25)32-20-9-4-3-5-10-20/h3-14,16H,2,15H2,1H3,(H,27,28,29) AYCGEPDRAMQQCS-UHFFFAOYSA-N 50111678 CHEMBL3605088 Nuclear receptor ROR-gamma Mus musculus 1585 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111678&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 60142996 319493460 CHEMBL3605088 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394248 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccccc3C(F)(F)F)s2)-c2cccc(Cl)c2)cc1 InChI=1S/C26H20ClF3N2O4S2/c1-2-38(34,35)19-12-10-16(11-13-19)14-22(33)31-25-32-23(17-6-5-7-18(27)15-17)24(37-25)36-21-9-4-3-8-20(21)26(28,29)30/h3-13,15H,2,14H2,1H3,(H,31,32,33) QDSXXUYMZGAZSR-UHFFFAOYSA-N 50111679 CHEMBL3605089 Nuclear receptor ROR-gamma Mus musculus 1995 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111679&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 88924610 319493461 CHEMBL3605089 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394249 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccccc3C(F)(F)F)s2)-c2cccc(c2)C#N)cc1 InChI=1S/C27H20F3N3O4S2/c1-2-39(35,36)20-12-10-17(11-13-20)15-23(34)32-26-33-24(19-7-5-6-18(14-19)16-31)25(38-26)37-22-9-4-3-8-21(22)27(28,29)30/h3-14H,2,15H2,1H3,(H,32,33,34) UXDXQSCFGRFMJV-UHFFFAOYSA-N 50111680 CHEMBL3605090 Nuclear receptor ROR-gamma Mus musculus 251 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111680&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 60142998 319493462 CHEMBL3605090 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394250 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccc(cc3Cl)C(F)(F)F)s2)-c2cccc(c2)C#N)cc1 InChI=1S/C27H19ClF3N3O4S2/c1-2-40(36,37)20-9-6-16(7-10-20)13-23(35)33-26-34-24(18-5-3-4-17(12-18)15-32)25(39-26)38-22-11-8-19(14-21(22)28)27(29,30)31/h3-12,14H,2,13H2,1H3,(H,33,34,35) DZKFAMMBDGZBLN-UHFFFAOYSA-N 50111583 CHEMBL3605092 Nuclear receptor ROR-gamma Mus musculus 398 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50111583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50111583&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 88925021 319493457 CHEMBL3605092 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50394251 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccc(Cl)cc3C(F)(F)F)s2)-c2cccc(c2)C#N)cc1 InChI=1S/C27H19ClF3N3O4S2/c1-2-40(36,37)20-9-6-16(7-10-20)13-23(35)33-26-34-24(18-5-3-4-17(12-18)15-32)25(39-26)38-22-11-8-19(28)14-21(22)27(29,30)31/h3-12,14H,2,13H2,1H3,(H,33,34,35) WXIRSECPLCRIQE-UHFFFAOYSA-N 50044146 CHEMBL3314014 Nuclear receptor ROR-gamma Mus musculus 158 ChEMBL 10.1016/j.bmc.2015.07.068 10.7270/Q27W6DZJ 26277758 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50044146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50044146&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 60142741 103975494 CHEMBL3314014 ZINC26156137 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382257 CN(C(=O)c1c(F)cccc1Cl)c1ccc(cc1OCC(F)(F)F)-c1cc(ccc1Cl)C(N)=O InChI=1S/C23H16Cl2F4N2O3/c1-31(22(33)20-16(25)3-2-4-17(20)26)18-8-6-12(10-19(18)34-11-23(27,28)29)14-9-13(21(30)32)5-7-15(14)24/h2-10H,11H2,1H3,(H2,30,32)/i1D3 NVMQCZDBIJGVBJ-FIBGUPNXSA-N 50105919 CHEMBL3596632 Nuclear receptor ROR-gamma Mus musculus 895 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105919&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 72721388 319492745 CHEMBL3596632 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382258 CC(C)n1nc(cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(OCC(F)(F)F)c1)C(N)=O InChI=1S/C23H21ClF4N4O3/c1-12(2)32-18(10-16(30-32)21(29)33)13-7-8-17(19(9-13)35-11-23(26,27)28)31(3)22(34)20-14(24)5-4-6-15(20)25/h4-10,12H,11H2,1-3H3,(H2,29,33)/i3D3 SNYNZBNBEOBCLP-HPRDVNIFSA-N 50105920 CHEMBL3598040 Nuclear receptor ROR-gamma Mus musculus 2000 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105920&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184187 319492746 CHEMBL3598040 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382259 CC(C)c1c(cnn1C)-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(OCC(F)(F)F)c1 InChI=1S/C23H22ClF4N3O2/c1-13(2)21-15(11-29-31(21)4)14-8-9-18(19(10-14)33-12-23(26,27)28)30(3)22(32)20-16(24)6-5-7-17(20)25/h5-11,13H,12H2,1-4H3/i3D3 ZZHULZAEOZXKFZ-HPRDVNIFSA-N 50105922 CHEMBL3598041 Nuclear receptor ROR-gamma Mus musculus 818 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105922&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184200 319492748 CHEMBL3598041 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382260 CC(C)n1nc(NC(C)=O)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(OCC2CCC2)c1 InChI=1S/C27H30ClFN4O3/c1-16(2)33-23(14-25(31-33)30-17(3)34)19-11-12-22(24(13-19)36-15-18-7-5-8-18)32(4)27(35)26-20(28)9-6-10-21(26)29/h6,9-14,16,18H,5,7-8,15H2,1-4H3,(H,30,31,34)/i4D3 IYXISBCRUGIJAV-GKOSEXJESA-N 50105925 CHEMBL3598044 Nuclear receptor ROR-gamma Mus musculus 3110 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105925&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184203 319492751 CHEMBL3598044 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382261 CC(C)n1nc(NC(C)=O)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CC2CC2C1 InChI=1S/C27H29ClFN5O2/c1-15(2)34-23(12-25(31-34)30-16(3)35)17-8-9-22(24(11-17)33-13-18-10-19(18)14-33)32(4)27(36)26-20(28)6-5-7-21(26)29/h5-9,11-12,15,18-19H,10,13-14H2,1-4H3,(H,30,31,35) JGJWPIOGJPAGQE-UHFFFAOYSA-N 50105928 CHEMBL3598047 Nuclear receptor ROR-gamma Mus musculus 38 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105928&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184115 319492754 CHEMBL3598047 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382262 CC(C)n1nc(NC(C)=O)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CCCC1 InChI=1S/C26H29ClFN5O2/c1-16(2)33-22(15-24(30-33)29-17(3)34)18-10-11-21(23(14-18)32-12-5-6-13-32)31(4)26(35)25-19(27)8-7-9-20(25)28/h7-11,14-16H,5-6,12-13H2,1-4H3,(H,29,30,34)/i4D3 JGWLJYUWJAGUIP-GKOSEXJESA-N 50105929 CHEMBL3598048 Nuclear receptor ROR-gamma Mus musculus 17 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105929&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184181 319492755 CHEMBL3598048 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382263 CC(C)n1nc(NC(C)=O)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CCCCC1 InChI=1S/C27H31ClFN5O2/c1-17(2)34-23(16-25(31-34)30-18(3)35)19-11-12-22(24(15-19)33-13-6-5-7-14-33)32(4)27(36)26-20(28)9-8-10-21(26)29/h8-12,15-17H,5-7,13-14H2,1-4H3,(H,30,31,35)/i4D3 CVPCMJOHHJOBAS-GKOSEXJESA-N 50105930 CHEMBL3598049 Nuclear receptor ROR-gamma Mus musculus 11 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105930&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184182 319492756 CHEMBL3598049 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382264 CC(C)n1nc(NC(C)=O)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CC2CC2C1 InChI=1S/C27H29ClFN5O2/c1-15(2)34-23(12-25(31-34)30-16(3)35)17-8-9-22(24(11-17)33-13-18-10-19(18)14-33)32(4)27(36)26-20(28)6-5-7-21(26)29/h5-9,11-12,15,18-19H,10,13-14H2,1-4H3,(H,30,31,35) JGJWPIOGJPAGQE-UHFFFAOYSA-N 50105933 CHEMBL3598051 Nuclear receptor ROR-gamma Mus musculus 110 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105933&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 4Q3 4ZOM 44347635 104001538 CHEMBL3598051 ZINC43860838 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382265 CC(C)n1nc(NC(C)=O)cc1-c1ccc(N(C)C(=O)c2c(Cl)cccc2Cl)c(c1)N1CC2CC2C1 InChI=1S/C27H29Cl2N5O2/c1-15(2)34-23(12-25(31-34)30-16(3)35)17-8-9-22(24(11-17)33-13-18-10-19(18)14-33)32(4)27(36)26-20(28)6-5-7-21(26)29/h5-9,11-12,15,18-19H,10,13-14H2,1-4H3,(H,30,31,35) ZWHNWMJLCJLVSY-UHFFFAOYSA-N 50105981 CHEMBL3598052 Nuclear receptor ROR-gamma Mus musculus 73 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105981&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184192 319492757 CHEMBL3598052 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382266 CC(C)n1nc(NC(C)=O)cc1-c1ccc(N(C)C(=O)c2c(C)cccc2F)c(c1)N1CC2CC2C1 InChI=1S/C28H32FN5O2/c1-16(2)34-24(13-26(31-34)30-18(4)35)19-9-10-23(25(12-19)33-14-20-11-21(20)15-33)32(5)28(36)27-17(3)7-6-8-22(27)29/h6-10,12-13,16,20-21H,11,14-15H2,1-5H3,(H,30,31,35) JTGPYKOMDSOGEO-UHFFFAOYSA-N 50105982 CHEMBL3598053 Nuclear receptor ROR-gamma Mus musculus 355 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105982&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184193 319492758 CHEMBL3598053 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382267 CCC(=O)Nc1cc(-c2ccc(N(C)C(=O)c3c(F)cccc3Cl)c(c2)N2CC3CC3C2)n(n1)C(C)C InChI=1S/C28H31ClFN5O2/c1-5-26(36)31-25-13-23(35(32-25)16(2)3)17-9-10-22(24(12-17)34-14-18-11-19(18)15-34)33(4)28(37)27-20(29)7-6-8-21(27)30/h6-10,12-13,16,18-19H,5,11,14-15H2,1-4H3,(H,31,32,36) UJLSPJKXJLYRGH-UHFFFAOYSA-N 50105988 CHEMBL3598056 Nuclear receptor ROR-gamma Mus musculus 33 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105988&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184207 319492761 CHEMBL3598056 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382268 CC(C)n1nc(NC(=O)C2CC2)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CC2CC2C1 InChI=1S/C29H31ClFN5O2/c1-16(2)36-24(13-26(33-36)32-28(37)17-7-8-17)18-9-10-23(25(12-18)35-14-19-11-20(19)15-35)34(3)29(38)27-21(30)5-4-6-22(27)31/h4-6,9-10,12-13,16-17,19-20H,7-8,11,14-15H2,1-3H3,(H,32,33,37) IFHFVAKJNPVICQ-UHFFFAOYSA-N 50105990 CHEMBL3598057 Nuclear receptor ROR-gamma Mus musculus 88 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105990&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184208 319492762 CHEMBL3598057 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382269 CC(C)C(=O)Nc1cc(-c2ccc(N(C)C(=O)c3c(F)cccc3Cl)c(c2)N2CC3CC3C2)n(n1)C(C)C InChI=1S/C29H33ClFN5O2/c1-16(2)28(37)32-26-13-24(36(33-26)17(3)4)18-9-10-23(25(12-18)35-14-19-11-20(19)15-35)34(5)29(38)27-21(30)7-6-8-22(27)31/h6-10,12-13,16-17,19-20H,11,14-15H2,1-5H3,(H,32,33,37) CNVZIRGUILLNPX-UHFFFAOYSA-N 50106014 CHEMBL3598058 Nuclear receptor ROR-gamma Mus musculus 128 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106014&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184209 319492781 CHEMBL3598058 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382270 [2H]C([2H])([2H])N(C(=O)c1c(F)cccc1Cl)c1ccc(cc1N1CC2CC2C1)-c1cc(NC(=O)[C@@H]2C[C@H](O)C2)nn1C(C)C InChI=1S/C30H33ClFN5O3/c1-16(2)37-25(13-27(34-37)33-29(39)18-10-21(38)11-18)17-7-8-24(26(12-17)36-14-19-9-20(19)15-36)35(3)30(40)28-22(31)5-4-6-23(28)32/h4-8,12-13,16,18-21,38H,9-11,14-15H2,1-3H3,(H,33,34,39)/t18-,19?,20?,21+/i3D3 XBIFCTLXILYDKJ-NTGFBHAESA-N 50106121 CHEMBL3598059 Nuclear receptor ROR-gamma Mus musculus 134 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106121&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 10487953 104001701 CHEMBL3598059 ZINC26746339 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382271 CC(C)n1nc(NC(=O)[C@H]2C[C@H](O)C2)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CC2CC2C1 InChI=1S/C30H33ClFN5O3/c1-16(2)37-25(13-27(34-37)33-29(39)18-10-21(38)11-18)17-7-8-24(26(12-17)36-14-19-9-20(19)15-36)35(3)30(40)28-22(31)5-4-6-23(28)32/h4-8,12-13,16,18-21,38H,9-11,14-15H2,1-3H3,(H,33,34,39)/t18-,19?,20?,21- XBIFCTLXILYDKJ-QEDDRRADSA-N 50105991 CHEMBL3598060 Nuclear receptor ROR-gamma Mus musculus 134 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105991&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184183 319492763 CHEMBL3598060 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382272 CC(C)n1nc(NC(=O)CO)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CC2CC2C1 InChI=1S/C27H29ClFN5O3/c1-15(2)34-22(11-24(31-34)30-25(36)14-35)16-7-8-21(23(10-16)33-12-17-9-18(17)13-33)32(3)27(37)26-19(28)5-4-6-20(26)29/h4-8,10-11,15,17-18,35H,9,12-14H2,1-3H3,(H,30,31,36) NPJTWUVIGAJRIL-UHFFFAOYSA-N 50105992 CHEMBL3598061 Nuclear receptor ROR-gamma Mus musculus 120 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105992&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184215 319492764 CHEMBL3598061 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382273 CNC(=O)Nc1cc(-c2ccc(N(C)C(=O)c3c(F)cccc3Cl)c(c2)N2CC3CC3C2)n(n1)C(C)C InChI=1S/C27H30ClFN6O2/c1-15(2)35-22(12-24(32-35)31-27(37)30-3)16-8-9-21(23(11-16)34-13-17-10-18(17)14-34)33(4)26(36)25-19(28)6-5-7-20(25)29/h5-9,11-12,15,17-18H,10,13-14H2,1-4H3,(H2,30,31,32,37) CMOXGPDNZHHEGP-UHFFFAOYSA-N 50105995 CHEMBL3598063 Nuclear receptor ROR-gamma Mus musculus 354 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105995&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184185 319492766 CHEMBL3598063 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382274 CC(C)n1nc(NC(=O)N2CC3(COC3)C2)cc1-c1ccc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CC2CC2C1 InChI=1S/C31H34ClFN6O3/c1-18(2)39-25(11-27(35-39)34-30(41)38-14-31(15-38)16-42-17-31)19-7-8-24(26(10-19)37-12-20-9-21(20)13-37)36(3)29(40)28-22(32)5-4-6-23(28)33/h4-8,10-11,18,20-21H,9,12-17H2,1-3H3,(H,34,35,41) SOCBDJZUDZXFGT-UHFFFAOYSA-N 50105997 CHEMBL3598064 Nuclear receptor ROR-gamma Mus musculus 148 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50105997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50105997&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184186 319492767 CHEMBL3598064 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382275 CN(C(=O)c1c(F)cccc1Cl)c1ccc(cc1N1CC2CC2C1)-c1cc(NC(C)=O)nn1C1CCCC1 InChI=1S/C29H31ClFN5O2/c1-17(37)32-27-14-25(36(33-27)21-6-3-4-7-21)18-10-11-24(26(13-18)35-15-19-12-20(19)16-35)34(2)29(38)28-22(30)8-5-9-23(28)31/h5,8-11,13-14,19-21H,3-4,6-7,12,15-16H2,1-2H3,(H,32,33,37) HLRDMFKUBGUXIF-UHFFFAOYSA-N 50106002 CHEMBL3598070 Nuclear receptor ROR-gamma Mus musculus 60 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106002&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184195 319492771 CHEMBL3598070 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382276 CN(C(=O)c1c(F)cccc1Cl)c1ccc(cc1N1CC2CC2C1)-c1cc(NC(C)=O)nn1C1CCC1 InChI=1S/C28H29ClFN5O2/c1-16(36)31-26-13-24(35(32-26)20-5-3-6-20)17-9-10-23(25(12-17)34-14-18-11-19(18)15-34)33(2)28(37)27-21(29)7-4-8-22(27)30/h4,7-10,12-13,18-20H,3,5-6,11,14-15H2,1-2H3,(H,31,32,36) FKTCUVHLBFADHY-UHFFFAOYSA-N 50106003 CHEMBL3598071 Nuclear receptor ROR-gamma Mus musculus 199 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106003&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184196 319492772 CHEMBL3598071 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382277 CN(C(=O)c1c(F)cccc1Cl)c1ccc(cc1N1CC2CC2C1)-c1cc(NC(C)=O)nn1CC1CC1 InChI=1S/C28H29ClFN5O2/c1-16(36)31-26-12-24(35(32-26)13-17-6-7-17)18-8-9-23(25(11-18)34-14-19-10-20(19)15-34)33(2)28(37)27-21(29)4-3-5-22(27)30/h3-5,8-9,11-12,17,19-20H,6-7,10,13-15H2,1-2H3,(H,31,32,36) OLKVAPHBBJHGSH-UHFFFAOYSA-N 50106007 CHEMBL3598074 Nuclear receptor ROR-gamma Mus musculus 201 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106007&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184198 319492775 CHEMBL3598074 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50382278 CC(C)n1nc(NC(C)=O)cc1-c1cnc(N(C)C(=O)c2c(F)cccc2Cl)c(c1)N1CCCCC1 InChI=1S/C26H30ClFN6O2/c1-16(2)34-21(14-23(31-34)30-17(3)35)18-13-22(33-11-6-5-7-12-33)25(29-15-18)32(4)26(36)24-19(27)9-8-10-20(24)28/h8-10,13-16H,5-7,11-12H2,1-4H3,(H,30,31,35) CZCYKTLYAQHJOI-UHFFFAOYSA-N 50106009 CHEMBL3598076 Nuclear receptor ROR-gamma Mus musculus 34 ChEMBL 10.1016/j.bmcl.2015.05.028 10.7270/Q2X3508H 26048789 Wang, T; Banerjee, D; Bohnert, T; Chao, J; Enyedy, I; Fontenot, J; Guertin, K; Jones, H; Lin, EY; Marcotte, D; Talreja, T; Van Vloten, K Biogen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50106009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50106009&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122184139 319492777 CHEMBL3598076 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477290 CCn1c(SCC(=O)Nc2cccc3ccccc23)nnc1C1Cc2ccccc2C1 InChI=1S/C25H24N4OS/c1-2-29-24(20-14-18-9-3-4-10-19(18)15-20)27-28-25(29)31-16-23(30)26-22-13-7-11-17-8-5-6-12-21(17)22/h3-13,20H,2,14-16H2,1H3,(H,26,30) FZEMCLIWPIMPQX-UHFFFAOYSA-N 50153596 CHEMBL3775765 Nuclear receptor ROR-gamma Mus musculus 700 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153596&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 127033009 340133233 CHEMBL3775765 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477291 CCn1c(OCC(=O)Nc2cccc3ccccc23)nnc1C1Cc2ccccc2C1 InChI=1S/C25H24N4O2/c1-2-29-24(20-14-18-9-3-4-10-19(18)15-20)27-28-25(29)31-16-23(30)26-22-13-7-11-17-8-5-6-12-21(17)22/h3-13,20H,2,14-16H2,1H3,(H,26,30) NOQXGINUCHHZNK-UHFFFAOYSA-N 50153599 CHEMBL3775014 Nuclear receptor ROR-gamma Mus musculus >20000 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153599&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 127031440 340133236 CHEMBL3775014 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477292 CCn1c(CCC(=O)Nc2cccc3ccccc23)nnc1C1Cc2ccccc2C1 InChI=1S/C26H26N4O/c1-2-30-24(28-29-26(30)21-16-19-9-3-4-10-20(19)17-21)14-15-25(31)27-23-13-7-11-18-8-5-6-12-22(18)23/h3-13,21H,2,14-17H2,1H3,(H,27,31) CIMGXRUSOPOFMC-UHFFFAOYSA-N 50153600 CHEMBL3774878 Nuclear receptor ROR-gamma Mus musculus 400 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153600&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 74222010 340133237 CHEMBL3774878 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477293 CCn1c(nnc1C1Cc2ccccc2C1)C(C)CC(=O)Nc1cccc2ccccc12 InChI=1S/C27H28N4O/c1-3-31-26(29-30-27(31)22-16-20-10-4-5-11-21(20)17-22)18(2)15-25(32)28-24-14-8-12-19-9-6-7-13-23(19)24/h4-14,18,22H,3,15-17H2,1-2H3,(H,28,32) XGFXJNFHRPTVAR-UHFFFAOYSA-N 50153601 CHEMBL3775184 Nuclear receptor ROR-gamma Mus musculus 1100 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153601&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121345843 340133238 CHEMBL3775184 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477294 CCn1c(CC(C)C(=O)Nc2cccc3ccccc23)nnc1C1Cc2ccccc2C1 InChI=1S/C27H28N4O/c1-3-31-25(29-30-26(31)22-16-20-10-4-5-11-21(20)17-22)15-18(2)27(32)28-24-14-8-12-19-9-6-7-13-23(19)24/h4-14,18,22H,3,15-17H2,1-2H3,(H,28,32) PWSUZERNRREPSY-UHFFFAOYSA-N 50153602 CHEMBL3774818 Nuclear receptor ROR-gamma Mus musculus 670 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153602&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121346196 340133239 CHEMBL3774818 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477295 CCn1c(nnc1C1Cc2ccccc2C1)C(O)CC(=O)Nc1cccc2ccccc12 InChI=1S/C26H26N4O2/c1-2-30-25(20-14-18-9-3-4-10-19(18)15-20)28-29-26(30)23(31)16-24(32)27-22-13-7-11-17-8-5-6-12-21(17)22/h3-13,20,23,31H,2,14-16H2,1H3,(H,27,32) PAQMKTSQYBYEJZ-UHFFFAOYSA-N 50153603 CHEMBL3774992 Nuclear receptor ROR-gamma Mus musculus >20000 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153603&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121345869 340133240 CHEMBL3774992 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477296 CCn1c(CCC(=O)Nc2cccc3ccccc23)nnc1C1CCCCC1 InChI=1S/C23H28N4O/c1-2-27-21(25-26-23(27)18-10-4-3-5-11-18)15-16-22(28)24-20-14-8-12-17-9-6-7-13-19(17)20/h6-9,12-14,18H,2-5,10-11,15-16H2,1H3,(H,24,28) RWFNZWUOJSDHGW-UHFFFAOYSA-N 50153604 CHEMBL3775198 Nuclear receptor ROR-gamma Mus musculus 4500 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153604&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121346194 340133241 CHEMBL3775198 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477297 CCn1c(CCC(=O)Nc2cccc3ccccc23)nnc1CC1CCCCC1 InChI=1S/C24H30N4O/c1-2-28-22(26-27-23(28)17-18-9-4-3-5-10-18)15-16-24(29)25-21-14-8-12-19-11-6-7-13-20(19)21/h6-8,11-14,18H,2-5,9-10,15-17H2,1H3,(H,25,29) SKBYTIIASSTFHO-UHFFFAOYSA-N 50153605 CHEMBL3774702 Nuclear receptor ROR-gamma Mus musculus 2600 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153605&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 90130850 340133242 CHEMBL3774702 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477298 CCn1c(CCC2CCCCC2)nnc1CCC(=O)Nc1cccc2ccccc12 InChI=1S/C25H32N4O/c1-2-29-23(16-15-19-9-4-3-5-10-19)27-28-24(29)17-18-25(30)26-22-14-8-12-20-11-6-7-13-21(20)22/h6-8,11-14,19H,2-5,9-10,15-18H2,1H3,(H,26,30) SZWIGRNIVUKPOZ-UHFFFAOYSA-N 50153606 CHEMBL3775900 Nuclear receptor ROR-gamma Mus musculus 300 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153606&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 4LQ 5AYG 118704903 340133243 CHEMBL3775900 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477299 CCn1c(CCC(C)C)nnc1CCC(=O)Nc1cccc2ccccc12 InChI=1S/C22H28N4O/c1-4-26-20(13-12-16(2)3)24-25-21(26)14-15-22(27)23-19-11-7-9-17-8-5-6-10-18(17)19/h5-11,16H,4,12-15H2,1-3H3,(H,23,27) SFLSFBBZAKRQJA-UHFFFAOYSA-N 50153607 CHEMBL3775499 Nuclear receptor ROR-gamma Mus musculus 1400 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153607&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121345821 340133244 CHEMBL3775499 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477301 CCn1c(CCC(=O)Nc2cccc3ccccc23)nnc1CCc1ccccc1 InChI=1S/C25H26N4O/c1-2-29-23(16-15-19-9-4-3-5-10-19)27-28-24(29)17-18-25(30)26-22-14-8-12-20-11-6-7-13-21(20)22/h3-14H,2,15-18H2,1H3,(H,26,30) QZKLCAKSRDREOS-UHFFFAOYSA-N 50153645 CHEMBL3774888 Nuclear receptor ROR-gamma Mus musculus 630 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153645&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121345638 340133245 CHEMBL3774888 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477302 CCn1c(CCC2CCCCC2)nnc1CCC(=O)Nc1cccc(Cl)c1C InChI=1S/C22H31ClN4O/c1-3-27-20(13-12-17-8-5-4-6-9-17)25-26-21(27)14-15-22(28)24-19-11-7-10-18(23)16(19)2/h7,10-11,17H,3-6,8-9,12-15H2,1-2H3,(H,24,28) WSGYCZCOEBMEQX-UHFFFAOYSA-N 50153646 CHEMBL3775781 Nuclear receptor ROR-gamma Mus musculus 640 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153646&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121345817 340133246 CHEMBL3775781 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477303 CCn1c(CCC2CCCCC2)nnc1CCC(=O)Nc1ccc(C)cc1C InChI=1S/C23H34N4O/c1-4-27-21(13-11-19-8-6-5-7-9-19)25-26-22(27)14-15-23(28)24-20-12-10-17(2)16-18(20)3/h10,12,16,19H,4-9,11,13-15H2,1-3H3,(H,24,28) JSSSSJQKWYAZCL-UHFFFAOYSA-N 50153595 CHEMBL3775930 Nuclear receptor ROR-gamma Mus musculus 600 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153595&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121346173 340133232 CHEMBL3775930 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477304 CCn1c(CCC2CCCCC2)nnc1CCC(=O)Nc1cc(C)cc(C)c1 InChI=1S/C23H34N4O/c1-4-27-21(11-10-19-8-6-5-7-9-19)25-26-22(27)12-13-23(28)24-20-15-17(2)14-18(3)16-20/h14-16,19H,4-13H2,1-3H3,(H,24,28) FHHJPIKZKMBVNW-UHFFFAOYSA-N 50153647 CHEMBL3774416 Nuclear receptor ROR-gamma Mus musculus 3100 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153647&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121346161 340133247 CHEMBL3774416 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477305 Cc1ccc(NC(=O)CCc2nnc(CCC3CCCCC3)n2C2CC2)c(C)c1 InChI=1S/C24H34N4O/c1-17-8-12-21(18(2)16-17)25-24(29)15-14-23-27-26-22(28(23)20-10-11-20)13-9-19-6-4-3-5-7-19/h8,12,16,19-20H,3-7,9-11,13-15H2,1-2H3,(H,25,29) TZXJSLWEEWUXGL-UHFFFAOYSA-N 50153648 CHEMBL3774668 Nuclear receptor ROR-gamma Mus musculus 450 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153648&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121345862 340133248 CHEMBL3774668 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477306 Cc1ccc(NC(=O)CCc2nnc(CCC3CCCCC3)n2C2CCC2)c(C)c1 InChI=1S/C25H36N4O/c1-18-11-13-22(19(2)17-18)26-25(30)16-15-24-28-27-23(29(24)21-9-6-10-21)14-12-20-7-4-3-5-8-20/h11,13,17,20-21H,3-10,12,14-16H2,1-2H3,(H,26,30) MWJNLALSLLUFEE-UHFFFAOYSA-N 50153649 CHEMBL3775324 Nuclear receptor ROR-gamma Mus musculus 1800 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153649&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 127032960 340133249 CHEMBL3775324 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477307 Cc1ccc(NC(=O)CCc2nnc(CCC3CCCCC3)n2C2CC2(F)F)c(C)c1 InChI=1S/C24H32F2N4O/c1-16-8-10-19(17(2)14-16)27-23(31)13-12-22-29-28-21(30(22)20-15-24(20,25)26)11-9-18-6-4-3-5-7-18/h8,10,14,18,20H,3-7,9,11-13,15H2,1-2H3,(H,27,31) LQYFWDFUXRXPEV-UHFFFAOYSA-N 50153650 CHEMBL3774648 Nuclear receptor ROR-gamma Mus musculus 500 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153650&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121345920 340133250 CHEMBL3774648 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477308 CCC(C)CCc1nnc(CCC(=O)Nc2ccc(C)cc2C)n1C1CC1 InChI=1S/C22H32N4O/c1-5-15(2)7-11-20-24-25-21(26(20)18-8-9-18)12-13-22(27)23-19-10-6-16(3)14-17(19)4/h6,10,14-15,18H,5,7-9,11-13H2,1-4H3,(H,23,27) UTGGRCANPVTWAT-UHFFFAOYSA-N 50153651 CHEMBL3775385 Nuclear receptor ROR-gamma Mus musculus 1400 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153651&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121346049 340133251 CHEMBL3775385 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477309 CC(C)CCCc1nnc(CCC(=O)Nc2ccc(C)cc2C)n1C1CC1 InChI=1S/C22H32N4O/c1-15(2)6-5-7-20-24-25-21(26(20)18-9-10-18)12-13-22(27)23-19-11-8-16(3)14-17(19)4/h8,11,14-15,18H,5-7,9-10,12-13H2,1-4H3,(H,23,27) MOJJWCCZEAQHHZ-UHFFFAOYSA-N 50153652 CHEMBL3774985 Nuclear receptor ROR-gamma Mus musculus 610 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153652&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121345804 340133252 CHEMBL3774985 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477310 Cc1ccc(NC(=O)CCc2nnc(CCCC(C)(C)C)n2C2CC2)c(C)c1 InChI=1S/C23H34N4O/c1-16-8-11-19(17(2)15-16)24-22(28)13-12-21-26-25-20(27(21)18-9-10-18)7-6-14-23(3,4)5/h8,11,15,18H,6-7,9-10,12-14H2,1-5H3,(H,24,28) NEOYDWPIRVPYKY-UHFFFAOYSA-N 50153653 CHEMBL3775443 Nuclear receptor ROR-gamma Mus musculus 1300 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153653&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121345902 340133253 CHEMBL3775443 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477311 CC(C)Cc1ccc(cc1)-c1nnc(CCC(=O)Nc2ccc(C)cc2C)n1C1CC1 InChI=1S/C26H32N4O/c1-17(2)15-20-6-8-21(9-7-20)26-29-28-24(30(26)22-10-11-22)13-14-25(31)27-23-12-5-18(3)16-19(23)4/h5-9,12,16-17,22H,10-11,13-15H2,1-4H3,(H,27,31) ZZTUGIVZKAXQBI-UHFFFAOYSA-N 50153654 CHEMBL3774848 Nuclear receptor ROR-gamma Mus musculus 120 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153654&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121346230 340133254 CHEMBL3774848 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477312 CC(C)Cc1cc(no1)-c1nnc(CCC(=O)Nc2ccc(C)cc2C)n1C1CC1 InChI=1S/C23H29N5O2/c1-14(2)11-18-13-20(27-30-18)23-26-25-21(28(23)17-6-7-17)9-10-22(29)24-19-8-5-15(3)12-16(19)4/h5,8,12-14,17H,6-7,9-11H2,1-4H3,(H,24,29) YQFIICDJTARFQZ-UHFFFAOYSA-N 50153655 CHEMBL3775227 Nuclear receptor ROR-gamma Mus musculus 54 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153655&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 127031148 340133255 CHEMBL3775227 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477313 CC(C)C[C@H]1C[C@@H](C1)c1nnc(CCC(=O)Nc2ccc(C)cc2C)n1C1CC1 InChI=1S/C24H34N4O/c1-15(2)11-18-13-19(14-18)24-27-26-22(28(24)20-6-7-20)9-10-23(29)25-21-8-5-16(3)12-17(21)4/h5,8,12,15,18-20H,6-7,9-11,13-14H2,1-4H3,(H,25,29)/t18-,19- QXVCIRQISSQIGQ-WGSAOQKQSA-N 50153656 CHEMBL3775304 Nuclear receptor ROR-gamma Mus musculus 53 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153656&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 90130771 340133256 CHEMBL3775304 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477314 CC(C)C[C@H]1C[C@H](C1)c1nnc(CCC(=O)Nc2ccc(C)cc2C)n1C1CC1 InChI=1S/C24H34N4O/c1-15(2)11-18-13-19(14-18)24-27-26-22(28(24)20-6-7-20)9-10-23(29)25-21-8-5-16(3)12-17(21)4/h5,8,12,15,18-20H,6-7,9-11,13-14H2,1-4H3,(H,25,29)/t18-,19+ QXVCIRQISSQIGQ-KDURUIRLSA-N 50153598 CHEMBL3775828 Nuclear receptor ROR-gamma Mus musculus 35 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153598&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 90130771 340133235 CHEMBL3775828 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477315 CC(C)C[C@H]1C[C@H](C1)c1nnc([C@H]2CCN(C)C[C@@H]2C(=O)Nc2ccc(C)cc2C)n1C1CC1 InChI=1S/C28H41N5O/c1-17(2)12-20-14-21(15-20)26-30-31-27(33(26)22-7-8-22)23-10-11-32(5)16-24(23)28(34)29-25-9-6-18(3)13-19(25)4/h6,9,13,17,20-24H,7-8,10-12,14-16H2,1-5H3,(H,29,34)/t20-,21+,23-,24-/m0/s1 SCOBGZSQIQVPNC-DVKRWUGUSA-N 50153657 CHEMBL3775607 Nuclear receptor ROR-gamma Mus musculus 290 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153657&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121346140 340133257 CHEMBL3775607 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477316 CC(C)C[C@H]1C[C@H](C1)c1nnc([C@H]2C[C@H](O)C[C@@H]2C(=O)Nc2ccc(C)cc2C)n1C1CC1 InChI=1S/C27H38N4O2/c1-15(2)9-18-11-19(12-18)25-29-30-26(31(25)20-6-7-20)22-13-21(32)14-23(22)27(33)28-24-8-5-16(3)10-17(24)4/h5,8,10,15,18-23,32H,6-7,9,11-14H2,1-4H3,(H,28,33)/t18-,19+,21-,22-,23-/m0/s1 SEBPCLRPUYJGQT-HUMDQVGNSA-N 50153597 CHEMBL3775807 Nuclear receptor ROR-gamma Mus musculus 38 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153597&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 90130762 340133234 CHEMBL3775807 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477317 CC(C)C[C@H]1C[C@H](C1)c1nnc([C@H]2CN(C[C@@H]2C(=O)Nc2ccc(C)cc2C)C(C)=O)n1C1CC1 InChI=1S/C28H39N5O2/c1-16(2)10-20-12-21(13-20)26-30-31-27(33(26)22-7-8-22)23-14-32(19(5)34)15-24(23)28(35)29-25-9-6-17(3)11-18(25)4/h6,9,11,16,20-24H,7-8,10,12-15H2,1-5H3,(H,29,35)/t20-,21+,23-,24-/m0/s1 NRAQMBSBKYAKMR-DVKRWUGUSA-N 50153594 CHEMBL3774855 Nuclear receptor ROR-gamma Mus musculus 29 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153594&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 82O 5X8X 121345502 340133231 CHEMBL3774855 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50477300 CCn1c(CCC(=O)Nc2cccc3ccccc23)nnc1CCC(C)(C)C InChI=1S/C23H30N4O/c1-5-27-20(25-26-21(27)15-16-23(2,3)4)13-14-22(28)24-19-12-8-10-17-9-6-7-11-18(17)19/h6-12H,5,13-16H2,1-4H3,(H,24,28) QYTORUPBBBFZKH-UHFFFAOYSA-N 50153622 CHEMBL3775712 Nuclear receptor ROR-gamma Mus musculus 830 ChEMBL 10.1021/acsmedchemlett.5b00253 10.7270/Q2N58P7P 26819660 Hirata, K; Kotoku, M; Seki, N; Maeba, T; Maeda, K; Hirashima, S; Sakai, T; Obika, S; Hori, A; Hase, Y; Yamaguchi, T; Katsuda, Y; Hata, T; Miyagawa, N; Arita, K; Nomura, Y; Asahina, K; Aratsu, Y; Kamada, M; Adachi, T; Noguchi, M; Doi, S; Crowe, P; Bradley, E; Steensma, R; Tao, H; Fenn, M; Babine, R; Li, X; Thacher, S; Hashimoto, H; Shiozaki, M Central Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50153622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50153622&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121346198 104041416 CHEMBL3775712 ZINC36248165 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089700 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(Cl)c(Cl)c4)ccc3c2)cc1 InChI=1S/C26H24Cl2N2O3S/c1-2-34(32,33)22-7-3-18(4-8-22)16-26(31)29-21-6-10-25-20(17-21)12-14-30(25)13-11-19-5-9-23(27)24(28)15-19/h3-10,12,14-15,17H,2,11,13,16H2,1H3,(H,29,31) PWFVKCKILCPBTI-UHFFFAOYSA-N 50446282 CHEMBL3109324 Nuclear receptor ROR-gamma Mus musculus 40 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446282&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 76313948 194944178 CHEMBL3109324 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089701 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(Cl)cc4Cl)ccc3c2)cc1 InChI=1S/C26H24Cl2N2O3S/c1-2-34(32,33)23-8-3-18(4-9-23)15-26(31)29-22-7-10-25-20(16-22)12-14-30(25)13-11-19-5-6-21(27)17-24(19)28/h3-10,12,14,16-17H,2,11,13,15H2,1H3,(H,29,31) WIBNEZIGZFNPGQ-UHFFFAOYSA-N 50446283 CHEMBL3109235 Nuclear receptor ROR-gamma Mus musculus 9.0 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446283&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73671285 194944179 CHEMBL3109235 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089702 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(OC(C)C)cc4)ccc3c2)cc1 InChI=1S/C29H32N2O4S/c1-4-36(33,34)27-12-7-23(8-13-27)19-29(32)30-25-9-14-28-24(20-25)16-18-31(28)17-15-22-5-10-26(11-6-22)35-21(2)3/h5-14,16,18,20-21H,4,15,17,19H2,1-3H3,(H,30,32) GIZAAIBWOAGCID-UHFFFAOYSA-N 50446286 CHEMBL3109232 Nuclear receptor ROR-gamma Mus musculus 70 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446286&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 76332063 194944182 CHEMBL3109232 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089703 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(cc4)C#N)ccc3c2)cc1 InChI=1S/C27H25N3O3S/c1-2-34(32,33)25-10-7-21(8-11-25)17-27(31)29-24-9-12-26-23(18-24)14-16-30(26)15-13-20-3-5-22(19-28)6-4-20/h3-12,14,16,18H,2,13,15,17H2,1H3,(H,29,31) PGAQNWMPGDENLH-UHFFFAOYSA-N 50446287 CHEMBL3109231 Nuclear receptor ROR-gamma Mus musculus 457 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446287&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 76332062 194944183 CHEMBL3109231 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089704 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(Cl)cc4)ccc3c2)cc1 InChI=1S/C26H25ClN2O3S/c1-2-33(31,32)24-10-5-20(6-11-24)17-26(30)28-23-9-12-25-21(18-23)14-16-29(25)15-13-19-3-7-22(27)8-4-19/h3-12,14,16,18H,2,13,15,17H2,1H3,(H,28,30) WVACOXRLCYETEG-UHFFFAOYSA-N 50446288 CHEMBL3109230 Nuclear receptor ROR-gamma Mus musculus 164 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446288&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 76328385 194944184 CHEMBL3109230 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089705 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc3n(CCc4ccc(cc4)C(F)(F)F)ccc3c2)cc1 InChI=1S/C27H25F3N2O3S/c1-2-36(34,35)24-10-5-20(6-11-24)17-26(33)31-23-9-12-25-21(18-23)14-16-32(25)15-13-19-3-7-22(8-4-19)27(28,29)30/h3-12,14,16,18H,2,13,15,17H2,1H3,(H,31,33) RRIHUBCIXULAKZ-UHFFFAOYSA-N 50446291 CHEMBL3109227 Nuclear receptor ROR-gamma Mus musculus 31 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446291 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446291&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73671284 194944187 CHEMBL3109227 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089706 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(NCCc3ccc(cc3)C(F)(F)F)c(Cl)c2)cc1 InChI=1S/C25H24ClF3N2O3S/c1-2-35(33,34)21-10-5-18(6-11-21)15-24(32)31-20-9-12-23(22(26)16-20)30-14-13-17-3-7-19(8-4-17)25(27,28)29/h3-12,16,30H,2,13-15H2,1H3,(H,31,32) WIKIALYFPNHYJC-UHFFFAOYSA-N 50446292 CHEMBL3109226 Nuclear receptor ROR-gamma Mus musculus 1023 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446292&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 76324830 194944188 CHEMBL3109226 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089707 CCCN(CCc1ccc(cc1)C(F)(F)F)c1ccc(NC(=O)Cc2ccc(cc2)S(=O)(=O)CC)cc1 InChI=1S/C28H31F3N2O3S/c1-3-18-33(19-17-21-5-9-23(10-6-21)28(29,30)31)25-13-11-24(12-14-25)32-27(34)20-22-7-15-26(16-8-22)37(35,36)4-2/h5-16H,3-4,17-20H2,1-2H3,(H,32,34) FATVRKBOUMMQKT-UHFFFAOYSA-N 50446293 CHEMBL3109225 Nuclear receptor ROR-gamma Mus musculus 733 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446293&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 76313943 194944189 CHEMBL3109225 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089708 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(CNCc3ccc(cc3)C(F)(F)F)cc2)cc1 InChI=1S/C25H25F3N2O3S/c1-2-34(32,33)23-13-7-18(8-14-23)15-24(31)30-22-11-5-20(6-12-22)17-29-16-19-3-9-21(10-4-19)25(26,27)28/h3-14,29H,2,15-17H2,1H3,(H,30,31) NUGSWBVVQAMLIF-UHFFFAOYSA-N 50446295 CHEMBL3109223 Nuclear receptor ROR-gamma Mus musculus >10000 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446295&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 76324829 194944191 CHEMBL3109223 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51089709 CCCN(Cc1ccc(NC(=O)Cc2ccc(cc2)S(=O)(=O)CC)cc1)Cc1ccc(cc1)C(F)(F)F InChI=1S/C28H31F3N2O3S/c1-3-17-33(19-22-5-11-24(12-6-22)28(29,30)31)20-23-7-13-25(14-8-23)32-27(34)18-21-9-15-26(16-10-21)37(35,36)4-2/h5-16H,3-4,17-20H2,1-2H3,(H,32,34) VQUKELFGZIHDQR-UHFFFAOYSA-N 50446298 CHEMBL3109329 Nuclear receptor ROR-gamma Mus musculus 320 ChEMBL 10.1021/ml4003875 10.7270/Q2794654 24900774 Yang, T; Liu, Q; Cheng, Y; Cai, W; Ma, Y; Yang, L; Wu, Q; Orband-Miller, LA; Zhou, L; Xiang, Z; Huxdorf, M; Zhang, W; Zhang, J; Xiang, JN; Leung, S; Qiu, Y; Zhong, Z; Elliott, JD; Lin, X; Wang, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50446298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50446298&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 76332069 194944194 CHEMBL3109329 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088894 CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(c(s2)C(=O)c2cccc(F)c2)-c2cccc(c2)C(F)(F)F)cc1 InChI=1S/C28H21F4NO4S2/c1-2-39(36,37)22-11-9-17(10-12-22)13-24(34)33-25-16-23(18-5-3-7-20(14-18)28(30,31)32)27(38-25)26(35)19-6-4-8-21(29)15-19/h3-12,14-16H,2,13H2,1H3,(H,33,34) NAUYVLIMXBJFHN-UHFFFAOYSA-N 50445879 CHEMBL3105672 Nuclear receptor ROR-gamma Mus musculus 13 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445879&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 59054468 194943775 CHEMBL3105672 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088895 CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(c(s2)C(=O)c2cccc(F)c2)-c2cccc(Cl)c2)cc1 InChI=1S/C27H21ClFNO4S2/c1-2-36(33,34)22-11-9-17(10-12-22)13-24(31)30-25-16-23(18-5-3-7-20(28)14-18)27(35-25)26(32)19-6-4-8-21(29)15-19/h3-12,14-16H,2,13H2,1H3,(H,30,31) XXPNMHPZWJXACX-UHFFFAOYSA-N 50445875 CHEMBL3105671 Nuclear receptor ROR-gamma Mus musculus 16 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445875&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 68276046 194943771 CHEMBL3105671 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088896 CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(c(s2)C(=O)c2ccccc2F)-c2cccc(Cl)c2)cc1 InChI=1S/C27H21ClFNO4S2/c1-2-36(33,34)20-12-10-17(11-13-20)14-24(31)30-25-16-22(18-6-5-7-19(28)15-18)27(35-25)26(32)21-8-3-4-9-23(21)29/h3-13,15-16H,2,14H2,1H3,(H,30,31) AAYKDTRBBPQGCJ-UHFFFAOYSA-N 50445880 CHEMBL3105670 Nuclear receptor ROR-gamma Mus musculus 10.0 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445880&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 68277108 194943776 CHEMBL3105670 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088897 CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(c(s2)C(=O)c2cccc(Cl)c2)-c2cccc(Cl)c2)cc1 InChI=1S/C27H21Cl2NO4S2/c1-2-36(33,34)22-11-9-17(10-12-22)13-24(31)30-25-16-23(18-5-3-7-20(28)14-18)27(35-25)26(32)19-6-4-8-21(29)15-19/h3-12,14-16H,2,13H2,1H3,(H,30,31) UTTWGXILYZAPMO-UHFFFAOYSA-N 50445881 CHEMBL3105669 Nuclear receptor ROR-gamma Mus musculus 25 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445881&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 68277128 194943777 CHEMBL3105669 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088898 CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(c(s2)C(=O)c2ccccc2Cl)-c2cccc(Cl)c2)cc1 InChI=1S/C27H21Cl2NO4S2/c1-2-36(33,34)20-12-10-17(11-13-20)14-24(31)30-25-16-22(18-6-5-7-19(28)15-18)27(35-25)26(32)21-8-3-4-9-23(21)29/h3-13,15-16H,2,14H2,1H3,(H,30,31) PDIFKINHSRCGJM-UHFFFAOYSA-N 50445876 CHEMBL3105692 Nuclear receptor ROR-gamma Mus musculus 25 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445876&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 57521310 194943772 CHEMBL3105692 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088899 CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(c(s2)C(=O)c2ccccc2)-c2cccc(c2)C#N)cc1 InChI=1S/C28H22N2O4S2/c1-2-36(33,34)23-13-11-19(12-14-23)16-25(31)30-26-17-24(22-10-6-7-20(15-22)18-29)28(35-26)27(32)21-8-4-3-5-9-21/h3-15,17H,2,16H2,1H3,(H,30,31) TYLLBTUIUGVOQR-UHFFFAOYSA-N 50445882 CHEMBL3105691 Nuclear receptor ROR-gamma Mus musculus 25 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445882&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 59054496 194943778 CHEMBL3105691 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088900 CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(c(s2)C(=O)c2ccccc2)-c2cccc(Cl)c2)cc1 InChI=1S/C27H22ClNO4S2/c1-2-35(32,33)22-13-11-18(12-14-22)15-24(30)29-25-17-23(20-9-6-10-21(28)16-20)27(34-25)26(31)19-7-4-3-5-8-19/h3-14,16-17H,2,15H2,1H3,(H,29,30) KJVGZSAFVVAUIG-UHFFFAOYSA-N 50445883 CHEMBL3105690 Nuclear receptor ROR-gamma Mus musculus 10.0 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445883&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 68276052 194943779 CHEMBL3105690 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088901 CCS(=O)(=O)c1ccc(CC(=O)Nc2cc(c(s2)C(=O)c2ccccc2)-c2ccccc2)cc1 InChI=1S/C27H23NO4S2/c1-2-34(31,32)22-15-13-19(14-16-22)17-24(29)28-25-18-23(20-9-5-3-6-10-20)27(33-25)26(30)21-11-7-4-8-12-21/h3-16,18H,2,17H2,1H3,(H,28,29) JBSXPUQDSVYBAE-UHFFFAOYSA-N 50445884 CHEMBL3105686 Nuclear receptor ROR-gamma Mus musculus 50 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445884&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 68277124 194943780 CHEMBL3105686 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088902 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2cccc(F)c2)-c2cccc(Cl)c2)cc1 InChI=1S/C26H20ClFN2O4S2/c1-2-36(33,34)21-11-9-16(10-12-21)13-22(31)29-26-30-23(17-5-3-7-19(27)14-17)25(35-26)24(32)18-6-4-8-20(28)15-18/h3-12,14-15H,2,13H2,1H3,(H,29,30,31) JTZDUAVNHDMASK-UHFFFAOYSA-N 50445885 CHEMBL3105685 Nuclear receptor ROR-gamma Mus musculus 200 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445885&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73333577 194943781 CHEMBL3105685 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088903 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2F)-c2cccc(Cl)c2)cc1 InChI=1S/C26H20ClFN2O4S2/c1-2-36(33,34)19-12-10-16(11-13-19)14-22(31)29-26-30-23(17-6-5-7-18(27)15-17)25(35-26)24(32)20-8-3-4-9-21(20)28/h3-13,15H,2,14H2,1H3,(H,29,30,31) BTOYRMRQYYZQLJ-UHFFFAOYSA-N 50445886 CHEMBL3105684 Nuclear receptor ROR-gamma Mus musculus 316 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445886&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73333576 194943782 CHEMBL3105684 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088904 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccc(Cl)cc2)-c2cccc(Cl)c2)cc1 InChI=1S/C26H20Cl2N2O4S2/c1-2-36(33,34)21-12-6-16(7-13-21)14-22(31)29-26-30-23(18-4-3-5-20(28)15-18)25(35-26)24(32)17-8-10-19(27)11-9-17/h3-13,15H,2,14H2,1H3,(H,29,30,31) VATCIRFWCXQUBO-UHFFFAOYSA-N 50445887 CHEMBL3105683 Nuclear receptor ROR-gamma Mus musculus 631 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445887&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73333488 194943783 CHEMBL3105683 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088905 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2cccc(Cl)c2)-c2cccc(Cl)c2)cc1 InChI=1S/C26H20Cl2N2O4S2/c1-2-36(33,34)21-11-9-16(10-12-21)13-22(31)29-26-30-23(17-5-3-7-19(27)14-17)25(35-26)24(32)18-6-4-8-20(28)15-18/h3-12,14-15H,2,13H2,1H3,(H,29,30,31) MFJQTDWFJSRKDL-UHFFFAOYSA-N 50445888 CHEMBL3105682 Nuclear receptor ROR-gamma Mus musculus 251 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445888&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73333487 194943784 CHEMBL3105682 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088906 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2Cl)-c2cccc(Cl)c2)cc1 InChI=1S/C26H20Cl2N2O4S2/c1-2-36(33,34)19-12-10-16(11-13-19)14-22(31)29-26-30-23(17-6-5-7-18(27)15-17)25(35-26)24(32)20-8-3-4-9-21(20)28/h3-13,15H,2,14H2,1H3,(H,29,30,31) GRWNPFJXINLSNF-UHFFFAOYSA-N 50445877 CHEMBL3105681 Nuclear receptor ROR-gamma Mus musculus 200 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445877&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 8YB 5NU1,5NI5 56837193 194943773 CHEMBL3105681 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088907 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2)-c2cccc(c2)C(O)=O)cc1 InChI=1S/C27H22N2O6S2/c1-2-37(34,35)21-13-11-17(12-14-21)15-22(30)28-27-29-23(19-9-6-10-20(16-19)26(32)33)25(36-27)24(31)18-7-4-3-5-8-18/h3-14,16H,2,15H2,1H3,(H,32,33)(H,28,29,30) YDMFEUDMZCMEQF-UHFFFAOYSA-N 50445889 CHEMBL3105680 Nuclear receptor ROR-gamma Mus musculus >10000 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445889&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 56848043 194943785 CHEMBL3105680 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088908 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2)-c2cccc(CN(C)C)c2)cc1 InChI=1S/C29H29N3O4S2/c1-4-38(35,36)24-15-13-20(14-16-24)18-25(33)30-29-31-26(23-12-8-9-21(17-23)19-32(2)3)28(37-29)27(34)22-10-6-5-7-11-22/h5-17H,4,18-19H2,1-3H3,(H,30,31,33) HMESUMWVSKICEE-UHFFFAOYSA-N 50445890 CHEMBL3105679 Nuclear receptor ROR-gamma Mus musculus >7943 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445890&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73333486 194943786 CHEMBL3105679 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088909 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2)-c2cccc(c2)C#N)cc1 InChI=1S/C27H21N3O4S2/c1-2-36(33,34)22-13-11-18(12-14-22)16-23(31)29-27-30-24(21-10-6-7-19(15-21)17-28)26(35-27)25(32)20-8-4-3-5-9-20/h3-15H,2,16H2,1H3,(H,29,30,31) HRAAQONRZAJFER-UHFFFAOYSA-N 50445891 CHEMBL3105678 Nuclear receptor ROR-gamma Mus musculus 158 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445891&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 56848145 194943787 CHEMBL3105678 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088910 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2)-c2ccc(Cl)cc2)cc1 InChI=1S/C26H21ClN2O4S2/c1-2-35(32,33)21-14-8-17(9-15-21)16-22(30)28-26-29-23(18-10-12-20(27)13-11-18)25(34-26)24(31)19-6-4-3-5-7-19/h3-15H,2,16H2,1H3,(H,28,29,30) MDGFZPGMRMKLBF-UHFFFAOYSA-N 50445892 CHEMBL3105677 Nuclear receptor ROR-gamma Mus musculus 794 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445892&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 56848095 194943788 CHEMBL3105677 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088911 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2)-c2cccc(Cl)c2)cc1 InChI=1S/C26H21ClN2O4S2/c1-2-35(32,33)21-13-11-17(12-14-21)15-22(30)28-26-29-23(19-9-6-10-20(27)16-19)25(34-26)24(31)18-7-4-3-5-8-18/h3-14,16H,2,15H2,1H3,(H,28,29,30) SIXZPIREJPLCQE-UHFFFAOYSA-N 50445893 CHEMBL3105676 Nuclear receptor ROR-gamma Mus musculus 126 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445893&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73333485 194943789 CHEMBL3105676 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088912 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2)-c2ccccc2Cl)cc1 InChI=1S/C26H21ClN2O4S2/c1-2-35(32,33)19-14-12-17(13-15-19)16-22(30)28-26-29-23(20-10-6-7-11-21(20)27)25(34-26)24(31)18-8-4-3-5-9-18/h3-15H,2,16H2,1H3,(H,28,29,30) DFKCZXNTLZJLBR-UHFFFAOYSA-N 50445894 CHEMBL3105675 Nuclear receptor ROR-gamma Mus musculus 398 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445894&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73333484 194943790 CHEMBL3105675 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51088913 CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(s2)C(=O)c2ccccc2)-c2ccccc2)cc1 InChI=1S/C26H22N2O4S2/c1-2-34(31,32)21-15-13-18(14-16-21)17-22(29)27-26-28-23(19-9-5-3-6-10-19)25(33-26)24(30)20-11-7-4-8-12-20/h3-16H,2,17H2,1H3,(H,27,28,29) MDMLFHGEDDZHNU-UHFFFAOYSA-N 50445895 CHEMBL3105674 Nuclear receptor ROR-gamma Mus musculus 316 ChEMBL 10.1016/j.bmc.2013.12.021 10.7270/Q2Z039M7 24388993 Wang, Y; Cai, W; Zhang, G; Yang, T; Liu, Q; Cheng, Y; Zhou, L; Ma, Y; Cheng, Z; Lu, S; Zhao, YG; Zhang, W; Xiang, Z; Wang, S; Yang, L; Wu, Q; Orband-Miller, LA; Xu, Y; Zhang, J; Gao, R; Huxdorf, M; Xiang, JN; Zhong, Z; Elliott, JD; Leung, S; Lin, X GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50445895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50445895&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search EF5 6G05 41145803 194943791 CHEMBL3105674 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725172 CCCC1=N[C@@H](CCCCN2C[C@H](Cc3ccccc3)N(CCCC3CCCC3)C2=S)CN1 InChI=1S/C28H44N4S/c1-2-11-27-29-21-25(30-27)17-8-9-18-31-22-26(20-24-14-4-3-5-15-24)32(28(31)33)19-10-16-23-12-6-7-13-23/h3-5,14-15,23,25-26H,2,6-13,16-22H2,1H3,(H,29,30)/t25-,26-/m0/s1 PGUIOSMKYOTJKP-UIOOFZCWSA-N 50235602 CHEMBL4101440 Nuclear receptor ROR-gamma Mus musculus 6400 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235602&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137658927 384991395 CHEMBL4101440 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725174 C\C=C\C1=N[C@@H](CCCCN2C[C@H](Cc3ccccc3)N(CCc3ccccc3)C2=S)CN1 InChI=1S/C28H36N4S/c1-2-11-27-29-21-25(30-27)16-9-10-18-31-22-26(20-24-14-7-4-8-15-24)32(28(31)33)19-17-23-12-5-3-6-13-23/h2-8,11-15,25-26H,9-10,16-22H2,1H3,(H,29,30)/b11-2+/t25-,26-/m0/s1 HCOGFOCMFHOUHT-DAZCNLPFSA-N 50235604 CHEMBL4088559 Nuclear receptor ROR-gamma Mus musculus 5800 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235604&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137644174 384991397 CHEMBL4088559 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725182 CCCC1=N[C@@H](CCCCN2C[C@H](Cc3ccccc3)N(CC3CCC(C)CC3)C2=S)CN1 InChI=1S/C28H44N4S/c1-3-9-27-29-19-25(30-27)12-7-8-17-31-21-26(18-23-10-5-4-6-11-23)32(28(31)33)20-24-15-13-22(2)14-16-24/h4-6,10-11,22,24-26H,3,7-9,12-21H2,1-2H3,(H,29,30)/t22?,24?,25-,26-/m0/s1 VXFUTSSNPDEHHM-SDAFTYILSA-N 50235605 CHEMBL4094612 Nuclear receptor ROR-gamma Mus musculus 13700 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235605&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137656123 384991398 CHEMBL4094612 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725189 Fc1ccc(CC2=N[C@@H](CCCCN3C[C@H](Cc4ccccc4)N(CCc4ccccc4)C3=S)CN2)cc1 InChI=1S/C32H37FN4S/c33-28-16-14-27(15-17-28)22-31-34-23-29(35-31)13-7-8-19-36-24-30(21-26-11-5-2-6-12-26)37(32(36)38)20-18-25-9-3-1-4-10-25/h1-6,9-12,14-17,29-30H,7-8,13,18-24H2,(H,34,35)/t29-,30-/m0/s1 ILDOXTACGLKNNB-KYJUHHDHSA-N 50235603 CHEMBL4091239 Nuclear receptor ROR-gamma Mus musculus 7700 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235603&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137642611 384991396 CHEMBL4091239 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725195 Cc1cccc(CC2=N[C@@H](CCCCN3C[C@H](Cc4ccccc4)N(CCc4ccccc4)C3=S)CN2)c1 InChI=1S/C33H40N4S/c1-26-11-10-16-29(21-26)23-32-34-24-30(35-32)17-8-9-19-36-25-31(22-28-14-6-3-7-15-28)37(33(36)38)20-18-27-12-4-2-5-13-27/h2-7,10-16,21,30-31H,8-9,17-20,22-25H2,1H3,(H,34,35)/t30-,31-/m0/s1 QLPBXLUVFUQXLE-CONSDPRKSA-N 50235607 CHEMBL4091903 Nuclear receptor ROR-gamma Mus musculus 6300 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235607&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137654410 384991400 CHEMBL4091903 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725196 S=C1N(CCCC[C@H]2CNC(CCC3CCCC3)=N2)C[C@H](Cc2ccccc2)N1CCc1ccccc1 InChI=1S/C32H44N4S/c37-32-35(21-10-9-17-29-24-33-31(34-29)19-18-26-13-7-8-14-26)25-30(23-28-15-5-2-6-16-28)36(32)22-20-27-11-3-1-4-12-27/h1-6,11-12,15-16,26,29-30H,7-10,13-14,17-25H2,(H,33,34)/t29-,30-/m0/s1 XJCMSTRNBCVOHG-KYJUHHDHSA-N 50235608 CHEMBL4067306 Nuclear receptor ROR-gamma Mus musculus 5600 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235608&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137633035 384991401 CHEMBL4067306 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725201 C=CCC1=N[C@@H](CCCCN2C[C@H](Cc3ccccc3)N(CCc3ccccc3)C2=S)CN1 InChI=1S/C28H36N4S/c1-2-11-27-29-21-25(30-27)16-9-10-18-31-22-26(20-24-14-7-4-8-15-24)32(28(31)33)19-17-23-12-5-3-6-13-23/h2-8,12-15,25-26H,1,9-11,16-22H2,(H,29,30)/t25-,26-/m0/s1 SMZBJNNJLBYYFH-UIOOFZCWSA-N 50235619 CHEMBL4073023 Nuclear receptor ROR-gamma Mus musculus 10200 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235619&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137640324 384991405 CHEMBL4073023 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725203 CC(CC1=N[C@@H](CCCCN2C[C@H](Cc3ccccc3)N(CCc3ccccc3)C2=S)CN1)c1ccccc1 InChI=1S/C34H42N4S/c1-27(30-17-9-4-10-18-30)23-33-35-25-31(36-33)19-11-12-21-37-26-32(24-29-15-7-3-8-16-29)38(34(37)39)22-20-28-13-5-2-6-14-28/h2-10,13-18,27,31-32H,11-12,19-26H2,1H3,(H,35,36)/t27?,31-,32-/m0/s1 QNKDXBRNEIOPHT-HUSUQQPPSA-N 50235617 CHEMBL4083451 Nuclear receptor ROR-gamma Mus musculus 6500 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235617&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137648178 384991403 CHEMBL4083451 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725205 Fc1cccc(CC2=N[C@@H](CCCCN3C[C@H](Cc4ccccc4)N(CCc4ccccc4)C3=S)CN2)c1 InChI=1S/C32H37FN4S/c33-28-15-9-14-27(20-28)22-31-34-23-29(35-31)16-7-8-18-36-24-30(21-26-12-5-2-6-13-26)37(32(36)38)19-17-25-10-3-1-4-11-25/h1-6,9-15,20,29-30H,7-8,16-19,21-24H2,(H,34,35)/t29-,30-/m0/s1 YABDGLYIQKEODM-KYJUHHDHSA-N 50235620 CHEMBL4063381 Nuclear receptor ROR-gamma Mus musculus 6600 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235620&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137636466 384991406 CHEMBL4063381 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725207 CCCC1=N[C@@H](CCCCN2C[C@H](Cc3ccccc3)N(CCC3C4CC5CC(C4)CC3C5)C2=S)CN1 InChI=1S/C32H48N4S/c1-2-8-31-33-21-28(34-31)11-6-7-13-35-22-29(20-23-9-4-3-5-10-23)36(32(35)37)14-12-30-26-16-24-15-25(18-26)19-27(30)17-24/h3-5,9-10,24-30H,2,6-8,11-22H2,1H3,(H,33,34)/t24?,25?,26?,27?,28-,29-,30?/m0/s1 YWXKEURVSUMZSF-VTEGQJLWSA-N 50235622 CHEMBL4085975 Nuclear receptor ROR-gamma Mus musculus 7900 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235622&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137641972 384991408 CHEMBL4085975 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725210 CCCC1=N[C@@H](CCCCN2C[C@H](Cc3ccccc3)N(CCC3CC4CCC3C4)C2=S)CN1 InChI=1S/C29H44N4S/c1-2-8-28-30-20-26(31-28)11-6-7-15-32-21-27(19-22-9-4-3-5-10-22)33(29(32)34)16-14-25-18-23-12-13-24(25)17-23/h3-5,9-10,23-27H,2,6-8,11-21H2,1H3,(H,30,31)/t23?,24?,25?,26-,27-/m0/s1 BHSQXIQZFCCWQV-CTEMSKPWSA-N 50235623 CHEMBL4064439 Nuclear receptor ROR-gamma Mus musculus 9300 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235623&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137637386 384991409 CHEMBL4064439 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725215 CCCC1=N[C@@H](CCCCN2C[C@H](N(CCc3ccccc3)C2=S)C(C)(C)C)CN1 InChI=1S/C25H40N4S/c1-5-11-23-26-18-21(27-23)14-9-10-16-28-19-22(25(2,3)4)29(24(28)30)17-15-20-12-7-6-8-13-20/h6-8,12-13,21-22H,5,9-11,14-19H2,1-4H3,(H,26,27)/t21-,22-/m0/s1 XYXDZATWEZKNKQ-VXKWHMMOSA-N 50235606 CHEMBL4067157 Nuclear receptor ROR-gamma Mus musculus 11800 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235606&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137634168 384991399 CHEMBL4067157 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725216 CCCC[C@H]1CN(CCCC[C@H]2CNC(CCC)=N2)C(=S)N1CCc1ccccc1 InChI=1S/C25H40N4S/c1-3-5-15-23-20-28(17-10-9-14-22-19-26-24(27-22)11-4-2)25(30)29(23)18-16-21-12-7-6-8-13-21/h6-8,12-13,22-23H,3-5,9-11,14-20H2,1-2H3,(H,26,27)/t22-,23-/m0/s1 QDOFYGLGUUDAKX-GOTSBHOMSA-N 50235618 CHEMBL4093723 Nuclear receptor ROR-gamma Mus musculus 10200 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235618&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137656343 384991404 CHEMBL4093723 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725218 COc1cccc(CC2=N[C@@H](CCCCN3C[C@H](Cc4ccccc4)N(CCc4ccccc4)C3=S)CN2)c1 InChI=1S/C33H40N4OS/c1-38-31-17-10-15-28(22-31)23-32-34-24-29(35-32)16-8-9-19-36-25-30(21-27-13-6-3-7-14-27)37(33(36)39)20-18-26-11-4-2-5-12-26/h2-7,10-15,17,22,29-30H,8-9,16,18-21,23-25H2,1H3,(H,34,35)/t29-,30-/m0/s1 JKGHACQJEXDNDH-KYJUHHDHSA-N 50235621 CHEMBL4071074 Nuclear receptor ROR-gamma Mus musculus 6300 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235621&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137639957 384991407 CHEMBL4071074 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 50725227 S=C1N(CCCC[C@H]2CNC(CC3CCCCC3)=N2)C[C@H](Cc2ccccc2)N1CCc1ccccc1 InChI=1S/C32H44N4S/c37-32-35(20-11-10-18-29-24-33-31(34-29)23-28-16-8-3-9-17-28)25-30(22-27-14-6-2-7-15-27)36(32)21-19-26-12-4-1-5-13-26/h1-2,4-7,12-15,28-30H,3,8-11,16-25H2,(H,33,34)/t29-,30-/m0/s1 AQHCGEKXMXOGSR-KYJUHHDHSA-N 50235609 CHEMBL4096280 Nuclear receptor ROR-gamma Mus musculus 5100 ChEMBL 10.1016/j.bmcl.2017.02.014 10.7270/Q29W0HRF 28242276 Nefzi, A; Marconi, GD; Ortiz, MA; Davis, JC; Piedrafita, FJ Torrey Pines Institute for Molecular Studies http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235609&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137655509 384991402 CHEMBL4096280 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663075 C\C=C\c1cccc(Cl)c1C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ncccc12 InChI=1S/C23H15ClFN3O3/c1-2-5-13-6-3-7-16(24)19(13)22(29)28-18-8-4-11-26-21(18)20(27-28)15-10-9-14(23(30)31)12-17(15)25/h2-12H,1H3,(H,30,31)/b5-2+ SDAFCQOHKWKKHV-GORDUTHDSA-N 332409 (E)-4-(1-(2-chloro-6-(prop-1-enyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid (1A)::US10196354, Example 1A::US9745265, 1A Nuclear receptor ROR-gamma Mus musculus 52.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332409&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296833 384577123 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663076 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccc(C=O)c12 InChI=1S/C23H12ClF3N2O4/c24-16-5-2-4-15(23(25,26)27)19(16)21(31)29-17-6-1-3-14(11-30)18(17)20(28-29)12-7-9-13(10-8-12)22(32)33/h1-11H,(H,32,33) IIYPHUTYQFNHTA-UHFFFAOYSA-N 332410 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-formyl-1H-indazol-3-yl)benzoic acid (1B)::US10196354, Example 1B::US9745265, 1B Nuclear receptor ROR-gamma Mus musculus 49.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332410&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296834 384577124 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663077 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3cccnc23)c(F)c1 InChI=1S/C23H15ClFN3O3/c24-16-4-1-3-14(12-6-7-12)19(16)22(29)28-18-5-2-10-26-21(18)20(27-28)15-9-8-13(23(30)31)11-17(15)25/h1-5,8-12H,6-7H2,(H,30,31) LMIWUTKCGKCAPR-UHFFFAOYSA-N 332411 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US10196354, Example 1C::US9745265, 1C Nuclear receptor ROR-gamma Mus musculus 6.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332411&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295597 384577125 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663078 OC(=O)c1ccc(-c2nn(C(=O)c3ccccn3)c3ccccc23)c(F)c1 InChI=1S/C20H12FN3O3/c21-15-11-12(20(26)27)8-9-13(15)18-14-5-1-2-7-17(14)24(23-18)19(25)16-6-3-4-10-22-16/h1-11H,(H,26,27) QZULWUXWLZAZRJ-UHFFFAOYSA-N 332412 3-fluoro-4-[1-(pyridin-2-ylcarbonyl)-1H-indazol-3-yl]benzoic acid (1D)::US10196354, Example 1D::US9745265, 1D Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332412&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118285875 384577126 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663079 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2OC2CC2)c2ccccc12 InChI=1S/C24H17ClN2O4/c25-18-5-3-7-20(31-16-12-13-16)21(18)23(28)27-19-6-2-1-4-17(19)22(26-27)14-8-10-15(11-9-14)24(29)30/h1-11,16H,12-13H2,(H,29,30) QHDQWVCHGBISAG-UHFFFAOYSA-N 336307 4-(1-(2-chloro-6- cyclypropoxybenzoyl)-1H- indazol-3-yl)benzoic acid::US9745265, 1H Nuclear receptor ROR-gamma Mus musculus 39.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336307&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 130356420 384988440 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663080 CC(C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ccccc12)c1ccccc1 InChI=1S/C23H17FN2O3/c1-14(15-7-3-2-4-8-15)22(27)26-20-10-6-5-9-18(20)21(25-26)17-12-11-16(23(28)29)13-19(17)24/h2-14H,1H3,(H,28,29) VWAYLDITYUHKSI-UHFFFAOYSA-N 332413 3-fluoro-4-(1- (2-phenyl- propanoyl)- 1H-indazol-3- yl)benzoic acid::US10196354, Example 1I::US9745265, 1I Nuclear receptor ROR-gamma Mus musculus 4324 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332413&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296837 384577127 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663081 COCC(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ccccc12 InChI=1S/C17H13FN2O4/c1-24-9-15(21)20-14-5-3-2-4-12(14)16(19-20)11-7-6-10(17(22)23)8-13(11)18/h2-8H,9H2,1H3,(H,22,23) BPPONUKAAREGJL-UHFFFAOYSA-N 332414 3-fluoro-4-[1- (methoxy- acetyl)-1H- indazol-3-yl] benzoic acid::US10196354, Example 1J::US9745265, 1J Nuclear receptor ROR-gamma Mus musculus 5569 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332414&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297005 384577128 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663082 OC(=O)c1ccc(-c2nn(C(=O)c3cccnc3)c3ccccc23)c(F)c1 InChI=1S/C20H12FN3O3/c21-16-10-12(20(26)27)7-8-14(16)18-15-5-1-2-6-17(15)24(23-18)19(25)13-4-3-9-22-11-13/h1-11H,(H,26,27) AHXGVYIRKMKSAV-UHFFFAOYSA-N 332415 3-fluoro-4-[1- (pyridin-3- ylcarbonyl)- 1H-indazol- 3-yl] benzoic acid::US10196354, Example 1K::US9745265, 1K Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332415&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297002 384577129 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663083 OC(=O)c1ccc(-c2nn(C(=O)CN3CCCC3=O)c3ccccc23)c(F)c1 InChI=1S/C20H16FN3O4/c21-15-10-12(20(27)28)7-8-13(15)19-14-4-1-2-5-16(14)24(22-19)18(26)11-23-9-3-6-17(23)25/h1-2,4-5,7-8,10H,3,6,9,11H2,(H,27,28) FEMMZTXFLFEFMF-UHFFFAOYSA-N 332416 3-fluoro-4-{1- [(2-oxo- pyrrolidin-1- yl)acetyl]-1H- indazol-3-yl} benzoic acid::US10196354, Example 1L::US9745265, 1L Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332416&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297003 384577130 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663084 OC(=O)c1ccc(-c2nn(C(=O)c3cccc4ccccc34)c3ccccc23)c(F)c1 InChI=1S/C25H15FN2O3/c26-21-14-16(25(30)31)12-13-19(21)23-20-9-3-4-11-22(20)28(27-23)24(29)18-10-5-7-15-6-1-2-8-17(15)18/h1-14H,(H,30,31) URJOBDIUNWPXTR-UHFFFAOYSA-N 332417 3-fluoro-4-[1- (naphthalen-1- ylcarbonyl)- 1H-indazol-3- yl]benzoic acid::US10196354, Example 1M::US9745265, 1M Nuclear receptor ROR-gamma Mus musculus 335 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332417&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297001 384577131 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663085 Cn1c(cc2ccccc12)C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ccccc12 InChI=1S/C24H16FN3O3/c1-27-19-8-4-2-6-14(19)13-21(27)23(29)28-20-9-5-3-7-17(20)22(26-28)16-11-10-15(24(30)31)12-18(16)25/h2-13H,1H3,(H,30,31) FGSXFZVLHMWUDU-UHFFFAOYSA-N 332418 3-fluoro-4-{1- [(1-methyl-1H- indol-2-yl) carbonyl]-1H- indazol-3- yl}benzoic acid::US10196354, Example 1N::US9745265, 1N Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332418&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297004 384577132 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663086 Cc1cccc(C(=O)n2nc(-c3ccc(cc3F)C(O)=O)c3ccccc23)c1Br InChI=1S/C22H14BrFN2O3/c1-12-5-4-7-16(19(12)23)21(27)26-18-8-3-2-6-15(18)20(25-26)14-10-9-13(22(28)29)11-17(14)24/h2-11H,1H3,(H,28,29) VQYAVXSWJIEBDY-UHFFFAOYSA-N 332419 4-{1-[(2-bromo- 3-methyl- phenyl) carbonyl]-1H- indazol-3-yl}- 3-fluoro- benzoic acid::US10196354, Example 1O::US9745265, 1O Nuclear receptor ROR-gamma Mus musculus 54.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332419&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297006 384577133 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663087 OC(=O)c1ccc(-c2nn(C(=O)c3cccc4CCCc34)c3ccccc23)c(F)c1 InChI=1S/C24H17FN2O3/c25-20-13-15(24(29)30)11-12-18(20)22-19-7-1-2-10-21(19)27(26-22)23(28)17-9-4-6-14-5-3-8-16(14)17/h1-2,4,6-7,9-13H,3,5,8H2,(H,29,30) ZQSOJGWWQMLPEG-UHFFFAOYSA-N 332420 4-[1-(2,3- dihydro-1H- inden-4- ylcarbonyl)-1H- indazol-3-yl]-3- fluorobenzoic acid::US10196354, Example 1P::US9745265, 1P Nuclear receptor ROR-gamma Mus musculus 58.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332420&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297167 384577134 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663088 CC(C)(C)OC(=O)N1CC2C(C1)C2C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ccccc12 InChI=1S/C25H24FN3O5/c1-25(2,3)34-24(33)28-11-16-17(12-28)20(16)22(30)29-19-7-5-4-6-15(19)21(27-29)14-9-8-13(23(31)32)10-18(14)26/h4-10,16-17,20H,11-12H2,1-3H3,(H,31,32) UFMFURBJBPRJFN-UHFFFAOYSA-N 332421 4-(1-{[3- (tertbutoxy- carbonyl)-3- azabicyclo [3.1.0]hex-6- yl]carbonyl}- 1H-indazol-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1Q::US9745265, 1Q Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332421&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297169 384577135 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663089 OC(=O)c1ccc(-c2nn(C(=O)c3cccc4CCOc34)c3ccccc23)c(F)c1 InChI=1S/C23H15FN2O4/c24-18-12-14(23(28)29)8-9-15(18)20-16-5-1-2-7-19(16)26(25-20)22(27)17-6-3-4-13-10-11-30-21(13)17/h1-9,12H,10-11H2,(H,28,29) HLQBLHMEGINUEZ-UHFFFAOYSA-N 332422 4-[1-(2,3- dihydro-1- benzofuran-7- ylcarbonyl)- 1H-indazol- 3-yl]-3-fluoro- benzoic acid::US10196354, Example 1R::US9745265, 1R Nuclear receptor ROR-gamma Mus musculus 969 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332422&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297168 384577136 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663090 OC(=O)c1ccc(-c2nn(C(=O)c3cccc4ccoc34)c3ccccc23)c(F)c1 InChI=1S/C23H13FN2O4/c24-18-12-14(23(28)29)8-9-15(18)20-16-5-1-2-7-19(16)26(25-20)22(27)17-6-3-4-13-10-11-30-21(13)17/h1-12H,(H,28,29) MYRZEDFAAXWOCE-UHFFFAOYSA-N 332423 4-[1-(1- benzofuran-7- ylcarbonyl)- 1H-indazol- 3-yl]-3-fluoro- benzoic acid::US10196354, Example 1S::US9745265, 1S Nuclear receptor ROR-gamma Mus musculus 1477 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332423&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297170 384577137 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663091 OC(=O)c1ccc(-c2nn(C(=O)c3cccc(Cl)c3Br)c3ccccc23)c(F)c1 InChI=1S/C21H11BrClFN2O3/c22-18-14(5-3-6-15(18)23)20(27)26-17-7-2-1-4-13(17)19(25-26)12-9-8-11(21(28)29)10-16(12)24/h1-10H,(H,28,29) KNXIOXOXYSMFDK-UHFFFAOYSA-N 332424 4-{1-[(2- bromo-3- chlorophenyl) carbonyl]-1H- indazol-3-yl}- 3-fluoro- benzoic acid::US10196354, Example 1T::US9745265, 1T Nuclear receptor ROR-gamma Mus musculus 159 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332424&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297171 384577138 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663092 OC(=O)c1ccc(-c2nn(C(=O)C3CCCO3)c3ccccc23)c(F)c1 InChI=1S/C19H15FN2O4/c20-14-10-11(19(24)25)7-8-12(14)17-13-4-1-2-5-15(13)22(21-17)18(23)16-6-3-9-26-16/h1-2,4-5,7-8,10,16H,3,6,9H2,(H,24,25) RQLYGRRZWKTFLU-UHFFFAOYSA-N 332425 3-fluoro-4-(1- (tetrahydro- furan-2- carbonyl)-1H- indazol-3-yl) benzoic acid::US10196354, Example 1U::US9745265, 1U Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332425&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73297172 384577139 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663093 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C=C)c3cccnc23)c(F)c1 InChI=1S/C22H13ClFN3O3/c1-2-12-5-3-6-15(23)18(12)21(28)27-17-7-4-10-25-20(17)19(26-27)14-9-8-13(22(29)30)11-16(14)24/h2-11H,1H2,(H,29,30) HYDRWUOWOHAYOO-UHFFFAOYSA-N 332426 4-(1-(2-chloro- 6-vinyl- benzoyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1V::US9745265, 1V Nuclear receptor ROR-gamma Mus musculus 16.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332426&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295598 384577140 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663094 CC(=C)c1cccc(Cl)c1C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ncccc12 InChI=1S/C23H15ClFN3O3/c1-12(2)14-5-3-6-16(24)19(14)22(29)28-18-7-4-10-26-21(18)20(27-28)15-9-8-13(23(30)31)11-17(15)25/h3-11H,1H2,2H3,(H,30,31) STTDKBXVHRDKSV-UHFFFAOYSA-N 332427 4-(1-(2-chloro- 6-(prop-1-en- 2-yl)benzoyl)- 1H-pyrazolo [4,3-b]pyridin- 3-yl)-3-fluoro- benzoic acid::US10196354, Example 1W::US9745265, 1W Nuclear receptor ROR-gamma Mus musculus 33.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332427&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295599 384577141 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663095 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)ccc4OCCOc34)c3cccnc23)c(F)c1 InChI=1S/C22H13ClFN3O5/c23-13-5-6-16-20(32-9-8-31-16)17(13)21(28)27-15-2-1-7-25-19(15)18(26-27)12-4-3-11(22(29)30)10-14(12)24/h1-7,10H,8-9H2,(H,29,30) ULGRACMCPGVEEK-UHFFFAOYSA-N 332428 4-(1-(6-chloro- 2,3-dihydro- benzo[b][1,4] dioxine-5- carbonyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1X::US9745265, 1X Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332428&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295600 384577142 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663096 CN(C)c1cccc(C)c1C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ncccc12 InChI=1S/C23H19FN4O3/c1-13-6-4-7-17(27(2)3)19(13)22(29)28-18-8-5-11-25-21(18)20(26-28)15-10-9-14(23(30)31)12-16(15)24/h4-12H,1-3H3,(H,30,31) ULWLHAACQVHNPR-UHFFFAOYSA-N 332429 4-(1-(2- (dimethyl- amino)-6- methyl- benzoyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1Y::US9745265, 1Y Nuclear receptor ROR-gamma Mus musculus 40.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332429&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295763 384577143 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663097 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3cccc(Cl)c23)c(F)c1 InChI=1S/C24H15Cl2FN2O3/c25-16-4-1-3-14(12-7-8-12)20(16)23(30)29-19-6-2-5-17(26)21(19)22(28-29)15-10-9-13(24(31)32)11-18(15)27/h1-6,9-12H,7-8H2,(H,31,32) ALIZPFBIRRYJQJ-UHFFFAOYSA-N 332430 4-(4-chloro-1- (2-chloro-6- cyclopropyl- benzoyl)-1H- indazol-3-yl)- 3-fluoro benzoic acid::US10196354, Example 1Z::US9745265, 1Z Nuclear receptor ROR-gamma Mus musculus 4.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332430&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295595 384577144 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663098 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3cccc(F)c23)c(F)c1 InChI=1S/C24H15ClF2N2O3/c25-16-4-1-3-14(12-7-8-12)20(16)23(30)29-19-6-2-5-17(26)21(19)22(28-29)15-10-9-13(24(31)32)11-18(15)27/h1-6,9-12H,7-8H2,(H,31,32) ITAJZCHZGRGIEJ-UHFFFAOYSA-N 332431 4-(1-(2- chloro-6- cyclopropyl- benzoyl)-4- fluoro-1H- indazol-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1AA::US9745265, 1AA Nuclear receptor ROR-gamma Mus musculus 2.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332431&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295764 384577145 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663099 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3CCC3)c3cccnc23)c(F)c1 InChI=1S/C24H17ClFN3O3/c25-17-7-2-6-15(13-4-1-5-13)20(17)23(30)29-19-8-3-11-27-22(19)21(28-29)16-10-9-14(24(31)32)12-18(16)26/h2-3,6-13H,1,4-5H2,(H,31,32) CKFNTMBCGYATAC-UHFFFAOYSA-N 332432 4-(1-(2- chloro-6- cyclobutyl- benzoyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1AB::US9745265, 1AB Nuclear receptor ROR-gamma Mus musculus 3.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332432&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295765 384577146 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663100 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3ccccc23)c(F)c1 InChI=1S/C24H16ClFN2O3/c25-18-6-3-5-15(13-8-9-13)21(18)23(29)28-20-7-2-1-4-17(20)22(27-28)16-11-10-14(24(30)31)12-19(16)26/h1-7,10-13H,8-9H2,(H,30,31) CSTNVZNXJBJIAB-UHFFFAOYSA-N 332433 4-(1-(2- chloro-6- cyclopropyl- benzoyl)-1H- indazol-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1AC::US9745265, 1AC Nuclear receptor ROR-gamma Mus musculus 2.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332433&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295766 384577147 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663101 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3N3CCOCC3)c3cccnc23)c(F)c1 InChI=1S/C24H18ClFN4O4/c25-16-3-1-4-18(29-9-11-34-12-10-29)20(16)23(31)30-19-5-2-8-27-22(19)21(28-30)15-7-6-14(24(32)33)13-17(15)26/h1-8,13H,9-12H2,(H,32,33) MRUIGUAOGXKSOD-UHFFFAOYSA-N 332434 4-(1-(2- chloro-6- morpholino- benzoyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)-3-fluoro- benzoic acid::US10196354, Example 1AD::US9745265, 1AD Nuclear receptor ROR-gamma Mus musculus 7.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332434&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295596 384577148 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663102 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)C(=O)N1CCOCC1 InChI=1S/C27H19ClF3N3O5/c28-20-3-1-2-19(27(29,30)31)22(20)25(36)34-21-14-17(24(35)33-10-12-39-13-11-33)8-9-18(21)23(32-34)15-4-6-16(7-5-15)26(37)38/h1-9,14H,10-13H2,(H,37,38) FOCBRZYNWUYTNP-UHFFFAOYSA-N 332435 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(morpholine-4-carbonyl)-1H-indazol-3-yl)benzoic acid (2A)::US10196354, Example 2A::US9745265, 7A Nuclear receptor ROR-gamma Mus musculus 16.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332435&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294749 384577149 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663103 C[C@H]1CN(C[C@@H](C)O1)C(=O)c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C29H22ClF4N3O5/c1-14-12-36(13-15(2)42-14)26(38)16-6-9-19-23(11-16)37(27(39)24-20(29(32,33)34)4-3-5-21(24)30)35-25(19)18-8-7-17(28(40)41)10-22(18)31/h3-11,14-15H,12-13H2,1-2H3,(H,40,41)/t14-,15+ FYCDYBZKAVRDMF-GASCZTMLSA-N 332436 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6- ((2S,6R)-2,6- dimethyl- morpholine-4- carbonyl)-1H- indazol-3-yl)-3- fluorobenzoic acid::US10196354, Example 2B::US9745265, 2B Nuclear receptor ROR-gamma Mus musculus 15.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332436&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294750 384577150 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663104 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)C(=O)N2CCC(=O)CC2)c(F)c1 InChI=1S/C28H18ClF4N3O5/c29-20-3-1-2-19(28(31,32)33)23(20)26(39)36-22-13-14(25(38)35-10-8-16(37)9-11-35)4-7-18(22)24(34-36)17-6-5-15(27(40)41)12-21(17)30/h1-7,12-13H,8-11H2,(H,40,41) IXANPMZGKWYZFR-UHFFFAOYSA-N 332437 4-(1-(2-chloro- 6-(trifluoro- methyl)benzoyl)- 6-(4-oxo- piperidine-1- carbonyl)-1H- indazol-3-yl)-3- fluorobenzoic acid::US10196354, Example 2C::US9745265, 2C Nuclear receptor ROR-gamma Mus musculus 4.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332437&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 72943444 384577151 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663105 CC(=O)Nc1cc(ccc1C(O)=O)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2ccccc12 InChI=1S/C24H15ClF3N3O4/c1-12(32)29-18-11-13(9-10-14(18)23(34)35)21-15-5-2-3-8-19(15)31(30-21)22(33)20-16(24(26,27)28)6-4-7-17(20)25/h2-11H,1H3,(H,29,32)(H,34,35) CUJAFWQPUBJJEJ-UHFFFAOYSA-N 332438 2-acetamido-4-(1-(2-chloro-6-(trifluoromethyl) benzoyl)-1H-indazol -3-yl)benzoic acid (3A).::US10196354, Example 3A::US9745265, 3A Nuclear receptor ROR-gamma Mus musculus 1466 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332438&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294751 384577152 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663106 CS(=O)(=O)Nc1cc(ccc1C(O)=O)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccnc12 InChI=1S/C22H14ClF3N4O5S/c1-36(34,35)29-15-10-11(7-8-12(15)21(32)33)18-19-16(6-3-9-27-19)30(28-18)20(31)17-13(22(24,25)26)4-2-5-14(17)23/h2-10,29H,1H3,(H,32,33) RWCUCCDRSMFEAJ-UHFFFAOYSA-N 332439 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-1H- pyrazolo[4,3- b]pyridin-3-yl)- 2-(methyl- sulfonamido) benzoic acid::US10196354, Example 3B::US9745265, 3B Nuclear receptor ROR-gamma Mus musculus 1653 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332439&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73336094 384577153 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663107 OC1CN(C1)c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O InChI=1S/C25H17ClF3N3O4/c26-19-3-1-2-18(25(27,28)29)21(19)23(34)32-20-10-15(31-11-16(33)12-31)8-9-17(20)22(30-32)13-4-6-14(7-5-13)24(35)36/h1-10,16,33H,11-12H2,(H,35,36) LRVWMBOXODREIZ-UHFFFAOYSA-N 336531 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-hydroxyazetidin-1-yl)-1H-indazol-3-yl)benzoic acid::US9745265, 4A Nuclear receptor ROR-gamma Mus musculus 500 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336531&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73336096 384988661 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663108 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)N2CCC2)c(F)c1 InChI=1S/C25H16ClF4N3O3/c26-18-4-1-3-17(25(28,29)30)21(18)23(34)33-20-12-14(32-9-2-10-32)6-8-16(20)22(31-33)15-7-5-13(24(35)36)11-19(15)27/h1,3-8,11-12H,2,9-10H2,(H,35,36) GOWRWZBVFKBQBE-UHFFFAOYSA-N 332441 4-(6-(azetidin-1-yl)- 1-(2-chloro-6- (trifluoromethyl) benzoyl)-1H-indazol- 3-yl)-3-fluoro-benzoic acid::US10196354, Example 4B::US9745265, 4B Nuclear receptor ROR-gamma Mus musculus 1326 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332441&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73336095 384577155 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663109 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(NC4CC4)ccc23)c(F)c1 InChI=1S/C25H16ClF4N3O3/c26-18-3-1-2-17(25(28,29)30)21(18)23(34)33-20-11-14(31-13-5-6-13)7-9-16(20)22(32-33)15-8-4-12(24(35)36)10-19(15)27/h1-4,7-11,13,31H,5-6H2,(H,35,36) JJRGEGKNUNIBHX-UHFFFAOYSA-N 332442 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6- (cyclopropyl- amino)-1H- indazol-3-yl)-3- fluorobenzoic acid::US10196354, Example 4D::US9745265, 4D Nuclear receptor ROR-gamma Mus musculus 130 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332442&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294752 384577156 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663110 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(NC4COC4)ccc23)c(F)c1 InChI=1S/C25H16ClF4N3O4/c26-18-3-1-2-17(25(28,29)30)21(18)23(34)33-20-9-13(31-14-10-37-11-14)5-7-16(20)22(32-33)15-6-4-12(24(35)36)8-19(15)27/h1-9,14,31H,10-11H2,(H,35,36) ARZXKYMGJALLBA-UHFFFAOYSA-N 332443 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6-(oxetan- 3-ylamino)-1H- indazol-3-yl)-3- fluorobenzoic acid::US10196354, Example 4F::US9745265, 4F Nuclear receptor ROR-gamma Mus musculus 23.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332443&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73336097 384577157 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663111 OC1CCN(C1)c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H18ClF4N3O4/c27-19-3-1-2-18(26(29,30)31)22(19)24(36)34-21-11-14(33-9-8-15(35)12-33)5-7-17(21)23(32-34)16-6-4-13(25(37)38)10-20(16)28/h1-7,10-11,15,35H,8-9,12H2,(H,37,38) RBBOZTVVJHOOLW-UHFFFAOYSA-N 332444 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6-(3- hydroxypyrrolidin- 1-yl)-1H-indazol- 3-yl)-3- fluorobenzoic acid::US10196354, Example 4G::US9745265, 4G Nuclear receptor ROR-gamma Mus musculus 1060 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332444&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294753 384577158 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663112 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)N1CCOCC1 InChI=1S/C26H19ClF3N3O4/c27-20-3-1-2-19(26(28,29)30)22(20)24(34)33-21-14-17(32-10-12-37-13-11-32)8-9-18(21)23(31-33)15-4-6-16(7-5-15)25(35)36/h1-9,14H,10-13H2,(H,35,36) PAOBWZISCVUZCX-UHFFFAOYSA-N 332445 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6- morpholino-1H- indazol-3-yl) benzoic acid::US10196354, Example 4H::US9745265, 4H Nuclear receptor ROR-gamma Mus musculus 4321 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332445&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73336185 384577159 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663113 COC(=O)Nc1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C24H14ClF4N3O5/c1-37-23(36)30-12-6-8-14-18(10-12)32(21(33)19-15(24(27,28)29)3-2-4-16(19)25)31-20(14)13-7-5-11(22(34)35)9-17(13)26/h2-10H,1H3,(H,30,36)(H,34,35) DYONLPUIJFGZCB-UHFFFAOYSA-N 336537 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(methoxycarbonylamino)-1H-indazol-3-yl)-3-fluorobenzoic acid ::US9745265, 5A Nuclear receptor ROR-gamma Mus musculus 255 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336537&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294907 384988667 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663114 CN(C(C)=O)c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C25H16ClF4N3O4/c1-12(34)32(2)14-7-9-16-20(11-14)33(23(35)21-17(25(28,29)30)4-3-5-18(21)26)31-22(16)15-8-6-13(24(36)37)10-19(15)27/h3-11H,1-2H3,(H,36,37) FICCBHFYEHKBFR-UHFFFAOYSA-N 332447 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(N-methylacetamido)-1H-indazol-3-yl)-3-fluorobenzoic acid (5B)::US10196354, Example 5B::US9745265, 5B Nuclear receptor ROR-gamma Mus musculus 153 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332447&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294908 384577161 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663115 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(NC(=O)C4CC4)ccc23)c(F)c1 InChI=1S/C26H16ClF4N3O4/c27-18-3-1-2-17(26(29,30)31)21(18)24(36)34-20-11-14(32-23(35)12-4-5-12)7-9-16(20)22(33-34)15-8-6-13(25(37)38)10-19(15)28/h1-3,6-12H,4-5H2,(H,32,35)(H,37,38) GBVSQIMQCOMFQI-UHFFFAOYSA-N 332448 4-(1-(2-chloro- 6-(trifluoro- methyl)benzoyl)- 6-(cyclopropyl- carboxamido)-1H-indazol-3-yl)-3-fluoro-benzoic acid::US10196354, Example 5C::US9745265, 5C Nuclear receptor ROR-gamma Mus musculus 314 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332448&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294909 384577162 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663116 CS(=O)(=O)Nc1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C23H14ClF4N3O5S/c1-37(35,36)30-12-6-8-14-18(10-12)31(21(32)19-15(23(26,27)28)3-2-4-16(19)24)29-20(14)13-7-5-11(22(33)34)9-17(13)25/h2-10,30H,1H3,(H,33,34) PTLLLSCDEUROFR-UHFFFAOYSA-N 332449 4-(1-(2-chloro- 6-(trifluoro- methyl)benzoyl)- 6-(methyl- sulfonamido)-1H-indazol-3-yl)-3-fluoro-benzoic acid::US10196354, Example 5D::US9745265, 5D Nuclear receptor ROR-gamma Mus musculus 493 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332449&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73336186 384577163 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663117 CNC(=O)Nc1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C24H15ClF4N4O4/c1-30-23(37)31-12-6-8-14-18(10-12)33(21(34)19-15(24(27,28)29)3-2-4-16(19)25)32-20(14)13-7-5-11(22(35)36)9-17(13)26/h2-10H,1H3,(H,35,36)(H2,30,31,37) FLHPZKAVRBMTRL-UHFFFAOYSA-N 332450 4-(1-(2-chloro- 6-(trifluoro- methyl)benzoyl)- 6-(3-methyl- ureido)-1H- indazol-3-yl)-3-fluoro-benzoic acid::US10196354, Example 5E::US9745265, 5E Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332450&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294911 384577164 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663118 CC(=O)Nc1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C24H14ClF4N3O4/c1-11(33)30-13-6-8-15-19(10-13)32(22(34)20-16(24(27,28)29)3-2-4-17(20)25)31-21(15)14-7-5-12(23(35)36)9-18(14)26/h2-10H,1H3,(H,30,33)(H,35,36) OWNZPMDXFBUQRT-UHFFFAOYSA-N 332451 4-(6-acetamido- 1-(2-chloro-6- (trifluoromethyl) benzoyl)-1H- indazol-3-yl)-3-fluorobenzoicacid::US10196354, Example 5F::US9745265, 5F Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332451&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294910 384577165 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663119 CN(c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O)S(C)(=O)=O InChI=1S/C24H16ClF4N3O5S/c1-31(38(2,36)37)13-7-9-15-19(11-13)32(22(33)20-16(24(27,28)29)4-3-5-17(20)25)30-21(15)14-8-6-12(23(34)35)10-18(14)26/h3-11H,1-2H3,(H,34,35) GPEMWWDSWVCSHF-UHFFFAOYSA-N 332452 4-(1-(2-chloro- 6-(trifluoro- methyl)benzoyl)- 6-(N-methyl- methyl- sulfonamido)-1H-indazol-3-yl)-3-fluoro-benzoic acid::US10196354, Example 5G::US9745265, 5G Nuclear receptor ROR-gamma Mus musculus 1502 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332452&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73336187 384577166 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663120 CNC(=O)N(C)c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C25H17ClF4N4O4/c1-31-24(38)33(2)13-7-9-15-19(11-13)34(22(35)20-16(25(28,29)30)4-3-5-17(20)26)32-21(15)14-8-6-12(23(36)37)10-18(14)27/h3-11H,1-2H3,(H,31,38)(H,36,37) PLUSZQBSIICZOQ-UHFFFAOYSA-N 332453 4-(1-(2-chloro- 6-(trifluoro- methyl)benzoyl)- 6-(1,3-dimethyl- ureido)-1H- indazol-3-yl)-3-fluorobenzoic::US10196354, Example 5H::US9745265, 5H Nuclear receptor ROR-gamma Mus musculus 491 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332453&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295076 384577167 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663121 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)N2CCNC2=O)c(F)c1 InChI=1S/C25H15ClF4N4O4/c26-17-3-1-2-16(25(28,29)30)20(17)22(35)34-19-11-13(33-9-8-31-24(33)38)5-7-15(19)21(32-34)14-6-4-12(23(36)37)10-18(14)27/h1-7,10-11H,8-9H2,(H,31,38)(H,36,37) QUQZHZHXCYMLID-UHFFFAOYSA-N 332454 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-oxo-imidazolidin-1-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid (6A)::US10196354, Example 6A::US9745265, 6A Nuclear receptor ROR-gamma Mus musculus 85.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332454&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73336188 384577168 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663122 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)N2CCC2=O)c(F)c1 InChI=1S/C25H14ClF4N3O4/c26-17-3-1-2-16(25(28,29)30)21(17)23(35)33-19-11-13(32-9-8-20(32)34)5-7-15(19)22(31-33)14-6-4-12(24(36)37)10-18(14)27/h1-7,10-11H,8-9H2,(H,36,37) BVGRJQDXWMSWJI-UHFFFAOYSA-N 332456 4-(6-(2-carboxyethylamino)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid (6C)::US10196354, Example 6C::US9745265, 6B Nuclear receptor ROR-gamma Mus musculus 25.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332456&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295077 384577170 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663123 OC(=O)CCNc1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C25H16ClF4N3O5/c26-17-3-1-2-16(25(28,29)30)21(17)23(36)33-19-11-13(31-9-8-20(34)35)5-7-15(19)22(32-33)14-6-4-12(24(37)38)10-18(14)27/h1-7,10-11,31H,8-9H2,(H,34,35)(H,37,38) FWXDCINMHCWFAU-UHFFFAOYSA-N 336547 4-(6-(2-carboxyethylamino)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid::US9745265, 6C Nuclear receptor ROR-gamma Mus musculus 22.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336547&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295078 384988677 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663124 CN1CCN(C1=O)c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H17ClF4N4O4/c1-33-9-10-34(25(33)39)14-6-8-16-20(12-14)35(23(36)21-17(26(29,30)31)3-2-4-18(21)27)32-22(16)15-7-5-13(24(37)38)11-19(15)28/h2-8,11-12H,9-10H2,1H3,(H,37,38) QBKOGSWXVFYMQO-UHFFFAOYSA-N 332457 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6-(3- methyl-2-oxo- imidazolidin-1-yl)- 1H-indazol-3-yl)-3-fluorobenzoicacid::US10196354, Example 6D::US9745265, 6D Nuclear receptor ROR-gamma Mus musculus 1511 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332457&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295079 384577171 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663125 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)N2CCCC2=O)c(F)c1 InChI=1S/C26H16ClF4N3O4/c27-18-4-1-3-17(26(29,30)31)22(18)24(36)34-20-12-14(33-10-2-5-21(33)35)7-9-16(20)23(32-34)15-8-6-13(25(37)38)11-19(15)28/h1,3-4,6-9,11-12H,2,5,10H2,(H,37,38) KJHFTRVYJRRVMF-UHFFFAOYSA-N 332458 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6-(2- oxopyrrolidin-1- yl)-1H-indazol- 3-yl)-3-fluoro- benzoic acid::US10196354, Example 6E::US9745265, 6E Nuclear receptor ROR-gamma Mus musculus 224 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332458&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295080 384577172 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663126 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)C(=O)N1CCOCC1 InChI=1S/C27H19ClF3N3O5/c28-20-3-1-2-19(27(29,30)31)22(20)25(36)34-21-14-17(24(35)33-10-12-39-13-11-33)8-9-18(21)23(32-34)15-4-6-16(7-5-15)26(37)38/h1-9,14H,10-13H2,(H,37,38) FOCBRZYNWUYTNP-UHFFFAOYSA-N 332435 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(morpholine-4-carbonyl)-1H-indazol-3-yl)benzoic acid (2A)::US10196354, Example 2A::US9745265, 7A Nuclear receptor ROR-gamma Mus musculus 69.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332435&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73294749 384577149 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663127 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)C(O)=O InChI=1S/C23H12ClF3N2O5/c24-16-3-1-2-15(23(25,26)27)18(16)20(30)29-17-10-13(22(33)34)8-9-14(17)19(28-29)11-4-6-12(7-5-11)21(31)32/h1-10H,(H,31,32)(H,33,34) RQBDVVCZSCAYQL-UHFFFAOYSA-N 336551 3-(4-carboxyphenyl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazole-6-carboxylic acid::US9745265, 7B Nuclear receptor ROR-gamma Mus musculus 317 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336551&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295248 384988681 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663128 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(cnc23)C(=O)NC2CC2)c(F)c1 InChI=1S/C25H15ClF4N4O4/c26-16-3-1-2-15(25(28,29)30)19(16)23(36)34-18-9-12(22(35)32-13-5-6-13)10-31-21(18)20(33-34)14-7-4-11(24(37)38)8-17(14)27/h1-4,7-10,13H,5-6H2,(H,32,35)(H,37,38) XJLOMCIFVCBGQP-UHFFFAOYSA-N 332461 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6- (cyclopropyl- carbamoyl)-1H- pyrazolo[4,3- b]pyridin-3-yl)-3- fluorobenzoic acid::US10196354, Example 7C::US9745265, 7C Nuclear receptor ROR-gamma Mus musculus 87.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332461&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73336189 384577175 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663129 CN(C1CC1)C(=O)c1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H17ClF4N4O4/c1-34(14-6-7-14)23(36)13-10-19-22(32-11-13)21(15-8-5-12(25(38)39)9-18(15)28)33-35(19)24(37)20-16(26(29,30)31)3-2-4-17(20)27/h2-5,8-11,14H,6-7H2,1H3,(H,38,39) KPPSRVSRXSXIEN-UHFFFAOYSA-N 336581 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6- (cyclopropyl (methyl)carbamoyl)-1H- pyrazolo[4,3- b]pyridin-3-yl)-3- fluorobenzoic acid::US9745265, 7D Nuclear receptor ROR-gamma Mus musculus 14.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336581&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295249 384988711 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663130 CC1COCCN1C(=O)c1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C27H19ClF4N4O5/c1-13-12-41-8-7-35(13)24(37)15-10-20-23(33-11-15)22(16-6-5-14(26(39)40)9-19(16)29)34-36(20)25(38)21-17(27(30,31)32)3-2-4-18(21)28/h2-6,9-11,13H,7-8,12H2,1H3,(H,39,40) AVRWBKUYFIKANO-UHFFFAOYSA-N 332463 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6-(3- methylmorpholine- 4-carbonyl)-1H- pyrazolo[4,3- b]pyridin-3-yl)-3- fluorobenzoic acid::US10196354, Example 7E::US9745265, 7E Nuclear receptor ROR-gamma Mus musculus 245 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332463&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295767 384577177 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663131 CC1COCC(C)N1C(=O)c1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C28H21ClF4N4O5/c1-13-11-42-12-14(2)36(13)25(38)16-9-21-24(34-10-16)23(17-7-6-15(27(40)41)8-20(17)30)35-37(21)26(39)22-18(28(31,32)33)4-3-5-19(22)29/h3-10,13-14H,11-12H2,1-2H3,(H,40,41) NVEKLBBZRYVJMB-UHFFFAOYSA-N 332464 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6-(3,5- dimethylmorpholine- 4-carbonyl)-1H- pyrazolo[4,3- b]pyridin-3-yl)-3- fluorobenzoic acid::US10196354, Example 7F::US9745265, 7F Nuclear receptor ROR-gamma Mus musculus 222 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332464&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295934 384577178 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663132 OC(C1CC1)c1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C25H16ClF4N3O4/c26-16-3-1-2-15(25(28,29)30)19(16)23(35)33-18-9-13(22(34)11-4-5-11)10-31-21(18)20(32-33)14-7-6-12(24(36)37)8-17(14)27/h1-3,6-11,22,34H,4-5H2,(H,36,37) MHRAJUWMBYVALM-UHFFFAOYSA-N 332466 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(cyclopropane-carbonyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid (8B)::US10196354, Example 8B::US9745265, 8A Nuclear receptor ROR-gamma Mus musculus 143 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332466&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295250 384577180 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663133 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(cnc23)C(=O)C2CC2)c(F)c1 InChI=1S/C25H14ClF4N3O4/c26-16-3-1-2-15(25(28,29)30)19(16)23(35)33-18-9-13(22(34)11-4-5-11)10-31-21(18)20(32-33)14-7-6-12(24(36)37)8-17(14)27/h1-3,6-11H,4-5H2,(H,36,37) CUBIWDUMSWMMRZ-UHFFFAOYSA-N 336585 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(cyclopropane-carbonyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US9745265, 8B Nuclear receptor ROR-gamma Mus musculus 283 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336585&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295251 384988715 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663134 OC(c1ncco1)c1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C25H13ClF4N4O5/c26-15-3-1-2-14(25(28,29)30)18(15)23(36)34-17-9-12(21(35)22-31-6-7-39-22)10-32-20(17)19(33-34)13-5-4-11(24(37)38)8-16(13)27/h1-10,21,35H,(H,37,38) WDPHOVASCHHXHY-UHFFFAOYSA-N 332467 4-(1-(2-chloro- 6-(trifluoromethyl) benzoyl)-6- (hydroxy(oxazol- 2-yl)methyl)-1H- pyrazolo[4,3- b]pyridine-3-yl)-3-fluorobenzoic acid::US10196354, Example 8C::US9745265, 8C Nuclear receptor ROR-gamma Mus musculus 218 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332467&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73334734 384577181 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663135 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(cnc23)C(=O)c2ncco2)c(F)c1 InChI=1S/C25H11ClF4N4O5/c26-15-3-1-2-14(25(28,29)30)18(15)23(36)34-17-9-12(21(35)22-31-6-7-39-22)10-32-20(17)19(33-34)13-5-4-11(24(37)38)8-16(13)27/h1-10H,(H,37,38) NTVUUWMYIXCQPR-UHFFFAOYSA-N 332468 4-(1-(2-chloro- 6-(trifluoromethyl) benzoyl)-6-(oxazole-2- carbonyl)-1H- pyrazolo[4,3- b]pyridin-3-yl)- 3-fluorobenzoic acid::US10196354, Example 8D::US9745265, 8D Nuclear receptor ROR-gamma Mus musculus 57.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332468&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295252 384577182 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663136 Cc1cnc(o1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C([O-])=O InChI=1S/C26H15ClF3N3O4/c1-13-12-31-23(37-13)16-9-10-17-20(11-16)33(32-22(17)14-5-7-15(8-6-14)25(35)36)24(34)21-18(26(28,29)30)3-2-4-19(21)27/h2-12H,1H3,(H,35,36)/p-1 QZUPDRDWKANKTI-UHFFFAOYSA-M 336588 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(5-methyloxazol-2-yl)-1H-indazol-3-yl)benzoate::US9745265, 9A Nuclear receptor ROR-gamma Mus musculus 63.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336588&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 138752730 384988718 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663137 Cc1cnc(o1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H14ClF4N3O4/c1-12-11-32-23(38-12)13-5-8-16-20(10-13)34(24(35)21-17(26(29,30)31)3-2-4-18(21)27)33-22(16)15-7-6-14(25(36)37)9-19(15)28/h2-11H,1H3,(H,36,37) SQPYZFSEMVSKBI-UHFFFAOYSA-N 332470 4-(1-(2-chloro- 6- (trifluoromethyl) benzoyl)-6-(5- methyloxazol- 2-yl)-1H- indazol-3-yl)-3- fluorobenzoic acid::US10196354, Example 9B::US9745265, 9B Nuclear receptor ROR-gamma Mus musculus 14.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332470&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295425 384577184 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663138 OCC#Cc1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O InChI=1S/C25H14ClF3N2O4/c26-19-5-1-4-18(25(27,28)29)21(19)23(33)31-20-13-14(3-2-12-32)6-11-17(20)22(30-31)15-7-9-16(10-8-15)24(34)35/h1,4-11,13,32H,12H2,(H,34,35) CXGPIKIGNUXFFU-UHFFFAOYSA-N 336590 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-hydroxyprop-1-ynyl)-1H-indazol-3-yl)benzoic acid::US9745265, 11A Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336590&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295426 384988720 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663139 CC(O)C#Cc1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H15ClF4N2O4/c1-13(34)5-6-14-7-9-17-21(11-14)33(24(35)22-18(26(29,30)31)3-2-4-19(22)27)32-23(17)16-10-8-15(25(36)37)12-20(16)28/h2-4,7-13,34H,1H3,(H,36,37) PMPPBNRULNNWNW-UHFFFAOYSA-N 336591 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-hydroxybut-1-ynyl)-1H-indazol-3-yl)-3-fluorobenzoic acid::US9745265, 12A Nuclear receptor ROR-gamma Mus musculus 105 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336591&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295427 384988721 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663140 NCC#Cc1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C25H14ClF4N3O3/c26-18-5-1-4-17(25(28,29)30)21(18)23(34)33-20-11-13(3-2-10-31)6-8-16(20)22(32-33)15-9-7-14(24(35)36)12-19(15)27/h1,4-9,11-12H,10,31H2,(H,35,36) OLJHROKPTPBUPY-UHFFFAOYSA-N 332473 4-(6-(3-aminoprop-1-ynyl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid (13A)::US10196354, Example 13A::US9745265, 13A Nuclear receptor ROR-gamma Mus musculus 20.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332473&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295428 384577187 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663141 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)C#C InChI=1S/C24H12ClF3N2O3/c1-2-13-6-11-16-19(12-13)30(29-21(16)14-7-9-15(10-8-14)23(32)33)22(31)20-17(24(26,27)28)4-3-5-18(20)25/h1,3-12H,(H,32,33) KIKXTRLDPJWURJ-UHFFFAOYSA-N 332474 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-ethynyl-1H-indazol-3-yl)benzoic acid (14A)::US10196354, Example 14A::US9745265, 14A Nuclear receptor ROR-gamma Mus musculus 137 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332474&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295590 384577188 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663142 Cc1noc(n1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C25H13ClF4N4O4/c1-11-31-22(38-33-11)12-5-8-15-19(10-12)34(23(35)20-16(25(28,29)30)3-2-4-17(20)26)32-21(15)14-7-6-13(24(36)37)9-18(14)27/h2-10H,1H3,(H,36,37) OXCXRHIUCVUGLH-UHFFFAOYSA-N 332475 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid (15A)::US10196354, Example 15A::US9745265, 15A Nuclear receptor ROR-gamma Mus musculus 241 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332475&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295591 384577189 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663143 OCc1cnc(o1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H14ClF4N3O5/c27-18-3-1-2-17(26(29,30)31)21(18)24(36)34-20-9-12(23-32-10-14(11-35)39-23)4-7-16(20)22(33-34)15-6-5-13(25(37)38)8-19(15)28/h1-10,35H,11H2,(H,37,38) DBLOLXXKJOBMTA-UHFFFAOYSA-N 332476 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(5-(hydroxymethyl)oxazol-2-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid (16A)::US10196354, Example 16A::US9745265, 16A Nuclear receptor ROR-gamma Mus musculus 21.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332476&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295592 384577190 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663144 Cn1cnc(c1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H15ClF4N4O3/c1-34-11-20(32-12-34)13-5-8-16-21(10-13)35(24(36)22-17(26(29,30)31)3-2-4-18(22)27)33-23(16)15-7-6-14(25(37)38)9-19(15)28/h2-12H,1H3,(H,37,38) FLOCZDVOIMRSCY-UHFFFAOYSA-N 332477 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(1-methyl-1H-imidazol-4-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid (17A)::US10196354, Example 17A::US9745265, 17A Nuclear receptor ROR-gamma Mus musculus 12.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332477&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73334735 384577191 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663145 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)-c2ncco2)c(F)c1 InChI=1S/C25H12ClF4N3O4/c26-17-3-1-2-16(25(28,29)30)20(17)23(34)33-19-11-12(22-31-8-9-37-22)4-7-15(19)21(32-33)14-6-5-13(24(35)36)10-18(14)27/h1-11H,(H,35,36) MUIQMFMWWHLGBL-UHFFFAOYSA-N 332478 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(oxazol-2-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid (18A)::US10196354, Example 18A::US9745265, 18A Nuclear receptor ROR-gamma Mus musculus 24.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332478&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295593 384577192 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663146 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)-c2ncc(Br)o2)c(F)c1 InChI=1S/C25H11BrClF4N3O4/c26-19-10-32-22(38-19)11-4-7-14-18(9-11)34(23(35)20-15(25(29,30)31)2-1-3-16(20)27)33-21(14)13-6-5-12(24(36)37)8-17(13)28/h1-10H,(H,36,37) FBJVFVUDDUPHAU-UHFFFAOYSA-N 332479 4-(6-(5-bromooxazol-2-yl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid::US10196354, Example 18B::US9745265, 18B Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332479&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295594 384577193 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663147 CN(C)C(=N\C#N)\c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H16ClF4N5O3/c1-35(2)23(33-12-32)13-6-9-16-20(11-13)36(24(37)21-17(26(29,30)31)4-3-5-18(21)27)34-22(16)15-8-7-14(25(38)39)10-19(15)28/h3-11H,1-2H3,(H,38,39)/b33-23+ BTUVDHKIRBWMFA-GZZLJNBRSA-N 336599 (E)-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(N′-cyano-N,N-dimethylcarbamimidoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid::US9745265, 19A Nuclear receptor ROR-gamma Mus musculus 888 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336599&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73334736 384988729 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663148 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)-c2n[nH]c(=O)o2)c(F)c1 InChI=1S/C24H11ClF4N4O5/c25-15-3-1-2-14(24(27,28)29)18(15)21(34)33-17-9-10(20-30-31-23(37)38-20)4-7-13(17)19(32-33)12-6-5-11(22(35)36)8-16(12)26/h1-9H,(H,31,37)(H,35,36) OXMNNYUNKCFBCA-UHFFFAOYSA-N 332481 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid (20A)::US10196354, Example 20A::US9745265, 20A Nuclear receptor ROR-gamma Mus musculus 120 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332481&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295759 384577195 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663149 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)-c2nnc[nH]2)c(F)c1 InChI=1S/C24H12ClF4N5O3/c25-16-3-1-2-15(24(27,28)29)19(16)22(35)34-18-9-11(21-30-10-31-32-21)4-7-14(18)20(33-34)13-6-5-12(23(36)37)8-17(13)26/h1-10H,(H,36,37)(H,30,31,32) IDRHROXCDMIJRG-UHFFFAOYSA-N 332482 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(4H-1,2,4-triazol-3-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid (21A)::US10196354, Example 21A::US9745265, 21A Nuclear receptor ROR-gamma Mus musculus 5.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332482&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295758 384577196 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663150 Cc1nnc(o1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C25H13ClF4N4O4/c1-11-31-32-22(38-11)12-5-8-15-19(10-12)34(23(35)20-16(25(28,29)30)3-2-4-17(20)26)33-21(15)14-7-6-13(24(36)37)9-18(14)27/h2-10H,1H3,(H,36,37) DOGGFBCVMGBQGM-UHFFFAOYSA-N 332483 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6-(5- methyl-1,3,4- oxadiazol-2-yl)- 1H-indazol-3-yl)- 3-fluorobenzoic acid::US10196354, Example 21B::US9745265, 21B Nuclear receptor ROR-gamma Mus musculus 17.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332483&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295760 384577197 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663151 Cn1ccnc1-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H15ClF4N4O3/c1-34-10-9-32-23(34)13-5-8-16-20(12-13)35(24(36)21-17(26(29,30)31)3-2-4-18(21)27)33-22(16)15-7-6-14(25(37)38)11-19(15)28/h2-12H,1H3,(H,37,38) NACDHOZIQUKVIW-UHFFFAOYSA-N 332484 4-(1-(2-chloro-6- (trifluoromethyl) benzoyl)-6-(1- methyl-1H- imidazol-2-yl)- 1H-indazol-3-yl)- 3-fluorobenzoic acid::US10196354, Example 21C::US9745265, 21C Nuclear receptor ROR-gamma Mus musculus 15.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332484&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295761 384577198 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663152 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1nccs1 InChI=1S/C25H13ClF3N3O3S/c26-18-3-1-2-17(25(27,28)29)20(18)23(33)32-19-12-15(22-30-10-11-36-22)8-9-16(19)21(31-32)13-4-6-14(7-5-13)24(34)35/h1-12H,(H,34,35) MJDRNEXQZCNMPI-UHFFFAOYSA-N 332485 4-(1-(2-chloro-6-trifluoromethylbenzoyl)-6-(thiazol-2-yl)-1H-indazol-3-yl)benzoic acid (22A)::US10196354, Example 22A::US9745265, 22A Nuclear receptor ROR-gamma Mus musculus 754 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332485&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118288246 384577199 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663153 Cn1cncc1-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O InChI=1S/C26H16ClF3N4O3/c1-33-13-31-12-21(33)16-9-10-17-20(11-16)34(32-23(17)14-5-7-15(8-6-14)25(36)37)24(35)22-18(26(28,29)30)3-2-4-19(22)27/h2-13H,1H3,(H,36,37) WFIGKMLTRWQOHK-UHFFFAOYSA-N 332486 4-[1-{[2-chloro- 6- (trifluoromethyl) phenyl]carbonyl}- 6-(1-methyl- lH-imidazol-5- yl)-1H-indazol- 3-yl]benzoic acid::US10196354, Example 22B::US9745265, 22B Nuclear receptor ROR-gamma Mus musculus 5606 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332486&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 90039191 384577200 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663154 Cc1cc(cs1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O InChI=1S/C27H16ClF3N2O3S/c1-14-11-18(13-37-14)17-9-10-19-22(12-17)33(32-24(19)15-5-7-16(8-6-15)26(35)36)25(34)23-20(27(29,30)31)3-2-4-21(23)28/h2-13H,1H3,(H,35,36) CXGHMXSAPRQXIK-UHFFFAOYSA-N 332487 4-[1-{[2-chloro- 6- (trifluoromethyl) phenyl]carbonyl}- 6-(5- methylthiophen- 3-yl)-1H- indazol-3- yl]benzoic acid::US10196354, Example 22C::US9745265, 22C Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332487&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118274978 384577201 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663155 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1ncccn1 InChI=1S/C26H14ClF3N4O3/c27-19-4-1-3-18(26(28,29)30)21(19)24(35)34-20-13-16(23-31-11-2-12-32-23)9-10-17(20)22(33-34)14-5-7-15(8-6-14)25(36)37/h1-13H,(H,36,37) CDDTUWDAFLCGTE-UHFFFAOYSA-N 332488 4-(1-{[2-chloro- 6- (trifluoromethyl) phenyl]carbonyl}- 6-pyrimidin-2- yl-1H-indazol-3- yl)benzoic acid::US10196354, Example 22D::US9745265, 22D Nuclear receptor ROR-gamma Mus musculus 155 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332488&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295762 384577202 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663156 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1ccncn1 InChI=1S/C26H14ClF3N4O3/c27-19-3-1-2-18(26(28,29)30)22(19)24(35)34-21-12-16(20-10-11-31-13-32-20)8-9-17(21)23(33-34)14-4-6-15(7-5-14)25(36)37/h1-13H,(H,36,37) RSRHBRNRWCKXDN-UHFFFAOYSA-N 332489 4-(1-{[2-chloro- 6- (trifluoromethyl) phenyl]carbonyl}- 6-pyrimidin-4- yl-1H-indazol-3- yl)benzoic acid::US10196354, Example 22E::US9745265, 22E Nuclear receptor ROR-gamma Mus musculus 1441 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332489&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295256 384577203 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663157 Cn1cnc(c1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O InChI=1S/C26H16ClF3N4O3/c1-33-12-20(31-13-33)16-9-10-17-21(11-16)34(32-23(17)14-5-7-15(8-6-14)25(36)37)24(35)22-18(26(28,29)30)3-2-4-19(22)27/h2-13H,1H3,(H,36,37) AOMVCSGXIXOKEM-UHFFFAOYSA-N 332490 4-[1-{[2-chloro- 6- (trifluoromethyl) phenyl]carbonyl}- 6-(1-methyl- 1H-imidazol-4- yl)-1H-indazol- 3-yl]benzoic acid::US10196354, Example 22F::US9745265, 22F Nuclear receptor ROR-gamma Mus musculus 39.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332490&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296101 384577204 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663158 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1cscn1 InChI=1S/C25H13ClF3N3O3S/c26-18-3-1-2-17(25(27,28)29)21(18)23(33)32-20-10-15(19-11-36-12-30-19)8-9-16(20)22(31-32)13-4-6-14(7-5-13)24(34)35/h1-12H,(H,34,35) SOLIBFAOUSRRQU-UHFFFAOYSA-N 332491 4-[1-{[2-chloro- 6- (trifluoromethyl) phenyl]carbonyl}- 6-(1,3-thiazol- 4-yl)-1H- indazol-3- yl]benzoic acid::US10196354, Example 22G::US9745265, 22G Nuclear receptor ROR-gamma Mus musculus 356 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332491&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 90041625 384577205 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663159 NCc1ccnc(c1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O InChI=1S/C28H18ClF3N4O3/c29-21-3-1-2-20(28(30,31)32)24(21)26(37)36-23-13-18(22-12-15(14-33)10-11-34-22)8-9-19(23)25(35-36)16-4-6-17(7-5-16)27(38)39/h1-13H,14,33H2,(H,38,39) XSLPFBFEJUJHTN-UHFFFAOYSA-N 332492 4-(6-[4- (aminomethyl) pyridin-2-yl]-1- {[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}- 1H-indazol-3- yl)benzoic acid::US10196354, Example 22H::US9745265, 22H Nuclear receptor ROR-gamma Mus musculus 37.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332492&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295929 384577206 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663160 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1ccccn1 InChI=1S/C27H15ClF3N3O3/c28-20-5-3-4-19(27(29,30)31)23(20)25(35)34-22-14-17(21-6-1-2-13-32-21)11-12-18(22)24(33-34)15-7-9-16(10-8-15)26(36)37/h1-14H,(H,36,37) VEBWPAOCBSLAJK-UHFFFAOYSA-N 332493 4-(1-{[2-chloro- 6- (trifluoromethyl) phenyl]carbonyl}- 6-pyridin-2-yl- 1H-indazol-3- yl)benzoic acid::US10196354, Example 22I::US9745265, 22I Nuclear receptor ROR-gamma Mus musculus 274 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332493&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73334825 384577207 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663161 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1cncs1 InChI=1S/C25H13ClF3N3O3S/c26-18-3-1-2-17(25(27,28)29)21(18)23(33)32-19-10-15(20-11-30-12-36-20)8-9-16(19)22(31-32)13-4-6-14(7-5-13)24(34)35/h1-12H,(H,34,35) JJOYOICIYBODAK-UHFFFAOYSA-N 332494 4-[1-{[2-chloro- 6- (trifluoromethyl) phenyl]carbonyl}- 6-(1,3-thiazol- 5-yl)-1H- indazoI-3- yl]benzoic acid::US10196354, Example 22J::US9745265, 22J Nuclear receptor ROR-gamma Mus musculus 6391 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332494&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295257 384577208 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663162 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1cccnc1 InChI=1S/C27H15ClF3N3O3/c28-21-5-1-4-20(27(29,30)31)23(21)25(35)34-22-13-17(18-3-2-12-32-14-18)10-11-19(22)24(33-34)15-6-8-16(9-7-15)26(36)37/h1-14H,(H,36,37) NGUYRHAASNRWFS-UHFFFAOYSA-N 332495 4-(1-(2-chloro-6-trifluoromethylbenzoyl)-6-(pyridin-3-yl)-1H-indazol-3-yl)benzoic acid (23A)::US10196354, Example 23A::US9745265, 23A Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332495&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118288218 384577209 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663163 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1ccncc1 InChI=1S/C27H15ClF3N3O3/c28-21-3-1-2-20(27(29,30)31)23(21)25(35)34-22-14-18(15-10-12-32-13-11-15)8-9-19(22)24(33-34)16-4-6-17(7-5-16)26(36)37/h1-14H,(H,36,37) UUUDMJKDJAOEQW-UHFFFAOYSA-N 332496 4-(1-{[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}-6- pyridin-4-yl-1H-indazol- 3-yl)benzoic acid::US10196354, Example 23B::US9745265, 23B Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332496&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73334826 384577210 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663164 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1ccc(cc1)C#N InChI=1S/C29H15ClF3N3O3/c30-23-3-1-2-22(29(31,32)33)25(23)27(37)36-24-14-20(17-6-4-16(15-34)5-7-17)12-13-21(24)26(35-36)18-8-10-19(11-9-18)28(38)39/h1-14H,(H,38,39) NCRZXDLOGZVMMH-UHFFFAOYSA-N 332497 4-[1-{[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}-6- (4-cyanophenyl)- 1H-indazol-3-yl]benzoic acid::US10196354, Example 23C::US9745265, 23C Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332497&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295429 384577211 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663165 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1cccc(c1)C#N InChI=1S/C29H15ClF3N3O3/c30-23-6-2-5-22(29(31,32)33)25(23)27(37)36-24-14-20(19-4-1-3-16(13-19)15-34)11-12-21(24)26(35-36)17-7-9-18(10-8-17)28(38)39/h1-14H,(H,38,39) ZLXRSGDRVFGXDV-UHFFFAOYSA-N 332498 4-[1-{[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}-6- (3-cyanophenyl)- 1H-indazol-3-yl]benzoic acid::US10196354, Example 23D::US9745265, 23D Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332498&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296102 384577212 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663166 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1ccccc1C#N InChI=1S/C29H15ClF3N3O3/c30-23-7-3-6-22(29(31,32)33)25(23)27(37)36-24-14-18(20-5-2-1-4-19(20)15-34)12-13-21(24)26(35-36)16-8-10-17(11-9-16)28(38)39/h1-14H,(H,38,39) DAEJUPFLIPARNN-UHFFFAOYSA-N 332499 4-[1-{[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}-6- (2-cyanophenyl)- 1H-indazol-3-yl]benzoic acid::US10196354, Example 23E::US9745265, 23E Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332499&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295430 384577213 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663167 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1cccs1 InChI=1S/C26H14ClF3N2O3S/c27-19-4-1-3-18(26(28,29)30)22(19)24(33)32-20-13-16(21-5-2-12-36-21)10-11-17(20)23(31-32)14-6-8-15(9-7-14)25(34)35/h1-13H,(H,34,35) MIFWNJNHHBSBJF-UHFFFAOYSA-N 332500 4-(1-{[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}-6- thiophen-2-yl-1H-indazol- 3-yl)benzoic acid::US10196354, Example 23F::US9745265, 23F Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332500&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118274982 384577214 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663168 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1ccccc1F InChI=1S/C28H15ClF4N2O3/c29-21-6-3-5-20(28(31,32)33)24(21)26(36)35-23-14-17(18-4-1-2-7-22(18)30)12-13-19(23)25(34-35)15-8-10-16(11-9-15)27(37)38/h1-14H,(H,37,38) MSZHHRWWKYFYFC-UHFFFAOYSA-N 332501 4-[1-{[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}-6- (2-fluorophenyl)- 1H-indazol-3-yl]benzoic acid::US10196354, Example 23G::US9745265, 23G Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332501&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296258 384577215 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663169 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1cccc(F)c1 InChI=1S/C28H15ClF4N2O3/c29-22-6-2-5-21(28(31,32)33)24(22)26(36)35-23-14-18(17-3-1-4-19(30)13-17)11-12-20(23)25(34-35)15-7-9-16(10-8-15)27(37)38/h1-14H,(H,37,38) UCTLSJKSGDDWPA-UHFFFAOYSA-N 332502 4-[1-{[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}-6- (3-fluorophenyl)- 1H-indazol-3-yl]benzoic acid::US10196354, Example 23H::US9745265, 23H Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332502&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295431 384577216 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663170 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1ccc(F)cc1 InChI=1S/C28H15ClF4N2O3/c29-22-3-1-2-21(28(31,32)33)24(22)26(36)35-23-14-18(15-8-11-19(30)12-9-15)10-13-20(23)25(34-35)16-4-6-17(7-5-16)27(37)38/h1-14H,(H,37,38) JHZRWXUYINHMEA-UHFFFAOYSA-N 332503 4-[1-{[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}-6- (4-fluorophenyl)- 1H-indazol-3-yl]benzoic acid::US10196354, Example 23I::US9745265, 23I Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332503&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296259 384577217 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663171 Cn1nccc1-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O InChI=1S/C26H16ClF3N4O3/c1-33-20(11-12-31-33)16-9-10-17-21(13-16)34(32-23(17)14-5-7-15(8-6-14)25(36)37)24(35)22-18(26(28,29)30)3-2-4-19(22)27/h2-13H,1H3,(H,36,37) BPUYMKDBEOEQSL-UHFFFAOYSA-N 332504 4-[1-{[2-chloro-6- (trifluoromethyl) phenyl]carbonyl}-6- (1-methyl-1H-pyrazol- 5-yl)-1H-indazol- 3-yl]benzoic acid::US10196354, Example 23J::US9745265, 23J Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332504&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295432 384577218 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663172 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cc(ccc12)-c1ccc(O)cc1 InChI=1S/C28H16ClF3N2O4/c29-22-3-1-2-21(28(30,31)32)24(22)26(36)34-23-14-18(15-8-11-19(35)12-9-15)10-13-20(23)25(33-34)16-4-6-17(7-5-16)27(37)38/h1-14,35H,(H,37,38) AFARZRHHVMXSDW-UHFFFAOYSA-N 332505 4-(1-(2-chloro- 6-trifluoromethylbenzoyl)- 6-(4-hydroxyphenyl)- 1H-indazol-3-yl) benzoic acid::US10196354, Example 23K::US9745265, 23K Nuclear receptor ROR-gamma Mus musculus >10000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332505&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 136252300 384577219 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663173 CS(=O)(=O)NCc1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1)C(O)=O InChI=1S/C24H17ClF3N3O5S/c1-37(35,36)29-12-13-5-10-16-19(11-13)31(30-21(16)14-6-8-15(9-7-14)23(33)34)22(32)20-17(24(26,27)28)3-2-4-18(20)25/h2-11,29H,12H2,1H3,(H,33,34) NMXIJMPFGPBHGZ-UHFFFAOYSA-N 332506 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(methylsulfonamidomethyl)-1H-indazol-3-yl)benzoic acid (26A)::US10196354, Example 26A::US9745265, 26A Nuclear receptor ROR-gamma Mus musculus 876 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332506&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73335022 384577220 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663174 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)C2NC(=O)NC2=O)c(F)c1 InChI=1S/C25H13ClF4N4O5/c26-15-3-1-2-14(25(28,29)30)18(15)22(36)34-17-9-10(19-21(35)32-24(39)31-19)4-7-13(17)20(33-34)12-6-5-11(23(37)38)8-16(12)27/h1-9,19H,(H,37,38)(H2,31,32,35,39) YNUXZWMHLUWWNJ-UHFFFAOYSA-N 332507 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2,5-dioxoimidazolidin-4-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid (27A)::US10196354, Example 27A::US9745265, 27A Nuclear receptor ROR-gamma Mus musculus 53.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332507&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295930 384577221 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663175 CC(C)(C)OC(=O)Nc1cc2c(cn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2cn1)-c1ccc(cc1F)C(O)=O InChI=1S/C27H20ClF4N3O5/c1-26(2,3)40-25(39)34-21-10-15-16(14-8-7-13(24(37)38)9-19(14)29)12-35(20(15)11-33-21)23(36)22-17(27(30,31)32)5-4-6-18(22)28/h4-12H,1-3H3,(H,37,38)(H,33,34,39) ZAFJKTHLHAQPER-UHFFFAOYSA-N 332508 4-(5-(tert-butoxycarbonylamino)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-3-fluorobenzoic acid (28A)::US10196354, Example 28A::US9745265, 28A Nuclear receptor ROR-gamma Mus musculus 182 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332508&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295931 384577222 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663176 CC(C)(C)OC(=O)Nc1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C26H19ClF4N4O5/c1-25(2,3)40-24(39)33-13-10-18-21(32-11-13)20(14-8-7-12(23(37)38)9-17(14)28)34-35(18)22(36)19-15(26(29,30)31)5-4-6-16(19)27/h4-11H,1-3H3,(H,33,39)(H,37,38) WHGQARDUXBSUDH-UHFFFAOYSA-N 332509 4-(6-(tert-butoxycarbonylamino)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid (29A) and 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(methylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid (29B)::US10196354, Example 29A::US9745265, 29A Nuclear receptor ROR-gamma Mus musculus 191 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332509&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295932 384577223 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663177 CNc1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C22H13ClF4N4O3/c1-28-11-8-16-19(29-9-11)18(12-6-5-10(21(33)34)7-15(12)24)30-31(16)20(32)17-13(22(25,26)27)3-2-4-14(17)23/h2-9,28H,1H3,(H,33,34) YJYCOMGZRKWOHW-UHFFFAOYSA-N 332510 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(methylamino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US10196354, Example 29B::US9745265, 29B Nuclear receptor ROR-gamma Mus musculus 13.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332510&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295933 384577224 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663178 CC(=O)Nc1cc2c(cn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2cn1)-c1ccc(cc1F)C(O)=O InChI=1S/C24H14ClF4N3O4/c1-11(33)31-20-8-14-15(13-6-5-12(23(35)36)7-18(13)26)10-32(19(14)9-30-20)22(34)21-16(24(27,28)29)3-2-4-17(21)25/h2-10H,1H3,(H,35,36)(H,30,31,33) RPWHNSYDDRMDCE-UHFFFAOYSA-N 332511 4-(5-acetamido-1-(2-chloro-6-(trifluoromethyl)-benzoyl)-1H-pyrrolo[2,3-c]pyridin-3-yl)-3-fluorobenzoic acid (30A) and 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-5-(methylamino)-1H-pyrrolo[2,3-c]pyridin-3-yl)-3-fluorobenzoic acid (30B)::US10196354, Example 30A::US9745265, 30A Nuclear receptor ROR-gamma Mus musculus 6.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332511&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295433 384577225 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663179 CNc1cc2c(cn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2cn1)-c1ccc(cc1F)C(O)=O InChI=1S/C23H14ClF4N3O3/c1-29-19-8-13-14(12-6-5-11(22(33)34)7-17(12)25)10-31(18(13)9-30-19)21(32)20-15(23(26,27)28)3-2-4-16(20)24/h2-10H,1H3,(H,29,30)(H,33,34) LDWYFJQKADHORK-UHFFFAOYSA-N 332512 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-5-(methylamino)-1H-pyrrolo[2,3-c]pyridin-3-yl)-3-fluorobenzoic acid::US10196354, Example 30B::US9745265, 30B Nuclear receptor ROR-gamma Mus musculus 209 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332512&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296096 384577226 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663180 COCCNc1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C24H17ClF4N4O4/c1-37-8-7-30-13-10-18-21(31-11-13)20(14-6-5-12(23(35)36)9-17(14)26)32-33(18)22(34)19-15(24(27,28)29)3-2-4-16(19)25/h2-6,9-11,30H,7-8H2,1H3,(H,35,36) KMGXHZZOYQXJDZ-UHFFFAOYSA-N 336634 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-methoxyethyl amino)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US9745265, 31A Nuclear receptor ROR-gamma Mus musculus 80.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336634&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295935 384988764 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663181 Cc1c(-c2ccc(cc2F)C(O)=O)c2ccccc2n1C(=O)c1c(Cl)cccc1C(F)(F)F InChI=1S/C24H14ClF4NO3/c1-12-20(14-10-9-13(23(32)33)11-18(14)26)15-5-2-3-8-19(15)30(12)22(31)21-16(24(27,28)29)6-4-7-17(21)25/h2-11H,1H3,(H,32,33) BIUDEVDBTBYDTN-UHFFFAOYSA-N 332514 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-2-methyl-1H-indol-3-yl)-3-fluorobenzoic acid::US10196354, Example 32A::US9745265, 32A Nuclear receptor ROR-gamma Mus musculus 29.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332514&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295936 384577228 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663182 Cc1c(-c2ccc(cc2)C(O)=O)c2ccccc2n1C(=O)c1ccccc1C(F)(F)F InChI=1S/C24H16F3NO3/c1-14-21(15-10-12-16(13-11-15)23(30)31)18-7-3-5-9-20(18)28(14)22(29)17-6-2-4-8-19(17)24(25,26)27/h2-13H,1H3,(H,30,31) NEPVVYYXRPGDHG-UHFFFAOYSA-N 332515 4-(2-methyl-1-(2- (trifluoromethyl)benzoyl)- 1H-indol-3-yl)benzoic acid::US10196354, Example 32B::US9745265, 32B Nuclear receptor ROR-gamma Mus musculus 384 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332515&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118274986 384577229 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663183 OC(=O)c1cc(F)c(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3cccnc23)c(F)c1 InChI=1S/C23H14ClF2N3O3/c24-14-4-1-3-13(11-6-7-11)18(14)22(30)29-17-5-2-8-27-20(17)21(28-29)19-15(25)9-12(23(31)32)10-16(19)26/h1-5,8-11H,6-7H2,(H,31,32) AMQKIZZEIKBRFO-UHFFFAOYSA-N 332516 4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid::US10196354, Example 33A::US9745265, 33A Nuclear receptor ROR-gamma Mus musculus 8.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332516&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295937 384577230 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663184 OC(=O)c1cc(F)c(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3ccccc23)c(F)c1 InChI=1S/C24H15ClF2N2O3/c25-16-6-3-5-14(12-8-9-12)20(16)23(30)29-19-7-2-1-4-15(19)22(28-29)21-17(26)10-13(24(31)32)11-18(21)27/h1-7,10-12H,8-9H2,(H,31,32) AAADBGOEWPPOQQ-UHFFFAOYSA-N 332517 4-(1-(2-chloro-6- cyclopropylbenzoyl)-1H- indazol-3-yl)-3,5- difluorobenzoic acid::US10196354, Example 33B::US9745265, 33B Nuclear receptor ROR-gamma Mus musculus 5.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332517&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118274992 384577231 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663185 OC(=O)c1cc(F)c(-c2nn(C(=O)c3c(Cl)cccc3C3CC3)c3cccc(F)c23)c(F)c1 InChI=1S/C24H14ClF3N2O3/c25-14-4-1-3-13(11-7-8-11)19(14)23(31)30-18-6-2-5-15(26)21(18)22(29-30)20-16(27)9-12(24(32)33)10-17(20)28/h1-6,9-11H,7-8H2,(H,32,33) RUPATPKYIMISQN-UHFFFAOYSA-N 332518 4-(1-(2-chloro-6- cyclopropylbenzoyl)-4- fluoro-1H-indazol-3-yl)- 3,5-difluorobenzoic acid::US10196354, Example 33C::US9745265, 33C Nuclear receptor ROR-gamma Mus musculus 5.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332518&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295938 384577232 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663186 OC(=O)c1cc(F)c(-c2cn(C(=O)c3c(Cl)cccc3C3CC3)c3cccnc23)c(F)c1 InChI=1S/C24H15ClF2N2O3/c25-16-4-1-3-14(12-6-7-12)20(16)23(30)29-11-15(22-19(29)5-2-8-28-22)21-17(26)9-13(24(31)32)10-18(21)27/h1-5,8-12H,6-7H2,(H,31,32) NAJJOZBHQMYRCQ-UHFFFAOYSA-N 332519 4-(1-(2-chloro-6- cyclopropylbenzoyl)-1H- pyrrolo[3,2-b]pyridin-3-yl)- 3,5-difluorobenzoic acid::US10196354, Example 33D::US9745265, 33D Nuclear receptor ROR-gamma Mus musculus 8.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332519&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296098 384577233 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663187 OC(=O)c1cc(F)c(-c2nn(C(=O)c3c(Cl)cccc3C3CCC3)c3cccnc23)c(F)c1 InChI=1S/C24H16ClF2N3O3/c25-15-7-2-6-14(12-4-1-5-12)19(15)23(31)30-18-8-3-9-28-21(18)22(29-30)20-16(26)10-13(24(32)33)11-17(20)27/h2-3,6-12H,1,4-5H2,(H,32,33) BCDKQBWCSBECKY-UHFFFAOYSA-N 332520 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-dilluorobenzoic acid::US10196354, Example 34A::US9745265, 44A Nuclear receptor ROR-gamma Mus musculus 3.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332520&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296403 384577234 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663188 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(cnc23)C(=O)N2CCCOC2)c(F)c1 InChI=1S/C26H17ClF4N4O5/c27-17-4-1-3-16(26(29,30)31)20(17)24(37)35-19-10-14(23(36)34-7-2-8-40-12-34)11-32-22(19)21(33-35)15-6-5-13(25(38)39)9-18(15)28/h1,3-6,9-11H,2,7-8,12H2,(H,38,39) VWLWIRYLQWWKSU-UHFFFAOYSA-N 332521 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(1,3-oxazinane-3-carbonyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US10196354, Example 35A::US9745265, 35A Nuclear receptor ROR-gamma Mus musculus 11.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332521&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 90042035 384577235 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663189 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(cnc23)C(=O)N2CCOC2)c(F)c1 InChI=1S/C25H15ClF4N4O5/c26-16-3-1-2-15(25(28,29)30)19(16)23(36)34-18-9-13(22(35)33-6-7-39-11-33)10-31-21(18)20(32-34)14-5-4-12(24(37)38)8-17(14)27/h1-5,8-10H,6-7,11H2,(H,37,38) ZXYDLCCOBGDIMX-UHFFFAOYSA-N 332522 4-(1-(2-chloro-6- (trifluoromethyl)benzoyl)- 6-(oxazolidine-3-carbonyl)- 1H-pyrazolo[4,3-b]pyridin- 3-yl)-3-fluorobenzoic acid::US10196354, Example 35B::US9745265, 35B Nuclear receptor ROR-gamma Mus musculus 3.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332522&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296099 384577236 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663190 OC(=O)c1ccc(-c2cn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)C(=O)N2CCC2)c(F)c1 InChI=1S/C27H17ClF4N2O4/c28-20-4-1-3-19(27(30,31)32)23(20)25(36)34-13-18(16-7-6-15(26(37)38)11-21(16)29)17-8-5-14(12-22(17)34)24(35)33-9-2-10-33/h1,3-8,11-13H,2,9-10H2,(H,37,38) LPBGSTHUDBPARL-UHFFFAOYSA-N 332523 4-(6-(azetidine-1-carbonyl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indol-3-yl)-3-fluorobenzoic acid::US10196354, Example 36A::US9745265, 36A Nuclear receptor ROR-gamma Mus musculus 2.00 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332523&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73295254 384577237 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663191 COC1CN(C1)C(=O)c1ccc2c(cn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C28H19ClF4N2O5/c1-40-16-11-34(12-16)25(36)14-5-8-18-19(17-7-6-15(27(38)39)9-22(17)30)13-35(23(18)10-14)26(37)24-20(28(31,32)33)3-2-4-21(24)29/h2-10,13,16H,11-12H2,1H3,(H,38,39) QWGWQRAYHKIEDH-UHFFFAOYSA-N 332524 4-(1-(2-chloro-6- (trifluoromethyl)benzoyl)-6- (3-methoxy-azetidine-1- carbonyl)-1H-indol-3-yl)-3- fluorobenzoic acid::US10196354, Example 36B::US9745265, 36B Nuclear receptor ROR-gamma Mus musculus 1.000 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332524&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 72943567 384577238 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663192 NC(=O)Cc1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C23H13ClF4N4O4/c24-14-3-1-2-13(23(26,27)28)18(14)21(34)32-16-6-10(7-17(29)33)9-30-20(16)19(31-32)12-5-4-11(22(35)36)8-15(12)25/h1-6,8-9H,7H2,(H2,29,33)(H,35,36) SNVCUFWHSXCXFG-UHFFFAOYSA-N 332525 4-(6-(2-amino-2-oxoethyl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US10196354, Example 37A::US9745265, 37A Nuclear receptor ROR-gamma Mus musculus 81.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332525&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296100 384577239 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663193 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(CC(=O)N4CCC4)cnc23)c(F)c1 InChI=1S/C26H17ClF4N4O4/c27-17-4-1-3-16(26(29,30)31)21(17)24(37)35-19-9-13(10-20(36)34-7-2-8-34)12-32-23(19)22(33-35)15-6-5-14(25(38)39)11-18(15)28/h1,3-6,9,11-12H,2,7-8,10H2,(H,38,39) MGTVGJZJGNRVRA-UHFFFAOYSA-N 332526 4-(6-(2-(azetidin-1-yl)-2- oxoethyl)-1-(2-chloro-6- (trifluoromethyl)benzoyl)- 1H-pyrazolo[4,3-b]pyridin- 3-yl)-3-fluorobenzoic acid::US10196354, Example 37B::US9745265, 37B Nuclear receptor ROR-gamma Mus musculus 225 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332526&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118274980 384577240 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663194 CNC(=O)Cc1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C24H15ClF4N4O4/c1-30-18(34)8-11-7-17-21(31-10-11)20(13-6-5-12(23(36)37)9-16(13)26)32-33(17)22(35)19-14(24(27,28)29)3-2-4-15(19)25/h2-7,9-10H,8H2,1H3,(H,30,34)(H,36,37) FBVPAOCGDMHZAL-UHFFFAOYSA-N 332527 4-(1-(2-chloro-6- (trifluoromethyl)benzoyl)- 6-(2-(methylamino)-2- oxoethyl)-1H-pyrazolo[4,3- b]pyridin-3-yl)-3- fluorobenzoic acid::US10196354, Example 37C::US9745265, 37C Nuclear receptor ROR-gamma Mus musculus 363 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332527&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296260 384577241 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663195 CN(C)C(=O)Cc1cnc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O InChI=1S/C25H17ClF4N4O4/c1-33(2)19(35)9-12-8-18-22(31-11-12)21(14-7-6-13(24(37)38)10-17(14)27)32-34(18)23(36)20-15(25(28,29)30)4-3-5-16(20)26/h3-8,10-11H,9H2,1-2H3,(H,37,38) IAHCCNRIJKPZTM-UHFFFAOYSA-N 332528 4-(1-(2-chloro-6- (trifluoromethyl)benzoyl)- 6-(2-(dimethylamino)-2- oxoethyl)-1H-pyrazolo[4,3- b]pyridin-3-yl)-3- fluorobenzoic acid::US10196354, Example 37D::US9745265, 37D Nuclear receptor ROR-gamma Mus musculus 458 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332528&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296261 384577242 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663196 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(ccc23)C2COC2)c(F)c1 InChI=1S/C25H15ClF4N2O4/c26-18-3-1-2-17(25(28,29)30)21(18)23(33)32-20-9-12(14-10-36-11-14)4-7-16(20)22(31-32)15-6-5-13(24(34)35)8-19(15)27/h1-9,14H,10-11H2,(H,34,35) ZROFOIOPEPLZAW-UHFFFAOYSA-N 332529 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(oxetan-3-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid::US10196354, Example 38A::US9745265, 38A Nuclear receptor ROR-gamma Mus musculus 784 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332529&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296262 384577243 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663197 COCCOc1cc(C)c(C(=O)n2nc(-c3ccc(cc3F)C(O)=O)c3ncccc23)c(Cl)c1 InChI=1S/C24H19ClFN3O5/c1-13-10-15(34-9-8-33-2)12-17(25)20(13)23(30)29-19-4-3-7-27-22(19)21(28-29)16-6-5-14(24(31)32)11-18(16)26/h3-7,10-12H,8-9H2,1-2H3,(H,31,32) OEJKIMIEMMNCSZ-UHFFFAOYSA-N 332530 4-(1-(2-chloro-4-(2-methoxyethoxy)-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US10196354, Example 39A::US9745265, 39A Nuclear receptor ROR-gamma Mus musculus 821 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332530&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296399 384577244 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663198 Cc1cc(cc(Cl)c1C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ncccc12)N1CCOCC1 InChI=1S/C25H20ClFN4O4/c1-14-11-16(30-7-9-35-10-8-30)13-18(26)21(14)24(32)31-20-3-2-6-28-23(20)22(29-31)17-5-4-15(25(33)34)12-19(17)27/h2-6,11-13H,7-10H2,1H3,(H,33,34) XQLORDGAAKKHJV-UHFFFAOYSA-N 332531 4-(1-(2-chloro-6-methyl-4-morpholinobenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US10196354, Example 40A::US9745265, 40A Nuclear receptor ROR-gamma Mus musculus 6866 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332531&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296400 384577245 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663199 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(cnc23)C(=O)N(C2CC2)C2CC2)c(F)c1 InChI=1S/C28H19ClF4N4O4/c29-19-3-1-2-18(28(31,32)33)22(19)26(39)37-21-11-14(25(38)36(15-5-6-15)16-7-8-16)12-34-24(21)23(35-37)17-9-4-13(27(40)41)10-20(17)30/h1-4,9-12,15-16H,5-8H2,(H,40,41) GFNVDMAOAOGBJS-UHFFFAOYSA-N 332532 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dicyclopropylcarbamoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US10196354, Example 41A::US9745265, 41A Nuclear receptor ROR-gamma Mus musculus 60.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332532&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296401 384577246 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663200 Cc1cc(N)cc(Cl)c1C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ncccc12 InChI=1S/C21H14ClFN4O3/c1-10-7-12(24)9-14(22)17(10)20(28)27-16-3-2-6-25-19(16)18(26-27)13-5-4-11(21(29)30)8-15(13)23/h2-9H,24H2,1H3,(H,29,30) SZTKTFVKDORSMX-UHFFFAOYSA-N 336654 4-(1-(4-amino-2-chloro-6-methylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US9745265, 42A Nuclear receptor ROR-gamma Mus musculus 2323 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=336654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=336654&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296402 384988784 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663201 OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3CCCC3)c3cccnc23)c(F)c1 InChI=1S/C25H19ClFN3O3/c26-18-8-3-7-16(14-5-1-2-6-14)21(18)24(31)30-20-9-4-12-28-23(20)22(29-30)17-11-10-15(25(32)33)13-19(17)27/h3-4,7-14H,1-2,5-6H2,(H,32,33) RDQQWHRZYWLWJC-UHFFFAOYSA-N 332534 4-(1-(2-chloro-6-cyclopentylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3-fluorobenzoic acid::US10196354, Example 43A::US9745265, 43A Nuclear receptor ROR-gamma Mus musculus 11.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332534&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 90041430 384577248 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 663202 OC(=O)c1cc(F)c(-c2nn(C(=O)c3c(Cl)cccc3C3CCC3)c3cccnc23)c(F)c1 InChI=1S/C24H16ClF2N3O3/c25-15-7-2-6-14(12-4-1-5-12)19(15)23(31)30-18-8-3-9-28-21(18)22(29-30)20-16(26)10-13(24(32)33)11-17(20)27/h2-3,6-12H,1,4-5H2,(H,32,33) BCDKQBWCSBECKY-UHFFFAOYSA-N 332520 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-dilluorobenzoic acid::US10196354, Example 34A::US9745265, 44A Nuclear receptor ROR-gamma Mus musculus 16.0 US Patent 10.7270/Q29G5PW2 aid1797053 US9745265 Barr, KJ; Bienstock, CE; Maclean, JK; Zhang, H; Beresis, RT; Zhang, D; Anthony, NJ; Lapointe, BT; Tian, Y Merck Sharp & Dohme Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=332520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=332520&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 73296403 384577234 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764904 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h6-11,15-17,23H,1-5,12-14H2,(H,40,41)/t16-,17-,23-,26-/m1/s1 FEJZVGPREBSBIT-NIULTJEISA-N 382173 (1R,4r)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 1::US10711020, Example 1 Nuclear receptor ROR-gamma Mus musculus 70.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382173&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search O5B 6U25 122669106 404851546 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764905 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c31-21-8-10-22(11-9-21)45(43,44)27-14-1-15-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)13-6-19-16-20(7-12-23(19)27)28(32,29(33,34)35)30(36,37)38/h7-12,16-18,24H,1-6,13-15H2,(H,41,42)/t17-,18-,24?,27? KRERFHRWSYRZOW-VRSFHCCXSA-N 382176 (1r,4r)-4-(10b-((4-fluorophenyl)sulfonyl)-8-(perfluoropropan-2-yl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline-4-carbonyl)cyclohexane-1-carboxylic acid (Homochiral)::US10273259, Example 2::US10711020, Example 2 Nuclear receptor ROR-gamma Mus musculus 89.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382176&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669184 404851549 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764906 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F9NO5S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-39(24(42)25(31)11-9-16(10-12-25)23(40)41)22(26)8-1-17-15-18(2-7-21(17)26)27(32,28(33,34)35)29(36,37)38/h2-7,15-16,22H,1,8-14H2,(H,40,41)/t16-,22-,25+,26-/m1/s1 IXBCMUKVFIGIKH-PNOGGZOTSA-N 382181 (1S,4s)-4-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid and (1S,4s)-1-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 3 Nuclear receptor ROR-gamma Mus musculus 65.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382181&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669173 404851554 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764907 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F9NO5S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-39(24(42)25(31)11-9-16(10-12-25)23(40)41)22(26)8-1-17-15-18(2-7-21(17)26)27(32,28(33,34)35)29(36,37)38/h2-7,15-16,22H,1,8-14H2,(H,40,41)/t16-,22-,25+,26-/m1/s1 IXBCMUKVFIGIKH-PNOGGZOTSA-N 382184 (1S,4s)-4-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid and (1S,4s)-1-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 4 Nuclear receptor ROR-gamma Mus musculus 107 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382184&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669173 404851557 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764908 CC[C@@]1(CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C31H31F8NO5S/c1-2-27(26(42)43)13-11-18(12-14-27)25(41)40-16-15-28(46(44,45)22-7-5-21(32)6-8-22)23-9-4-20(17-19(23)3-10-24(28)40)29(33,30(34,35)36)31(37,38)39/h4-9,17-18,24H,2-3,10-16H2,1H3,(H,42,43)/t18-,24-,27-,28-/m1/s1 YUIPIAPKYWCRFZ-IOPUSJGHSA-N 382187 (1R,4r)-1-ethyl-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 5::US10711020, Example 5 Nuclear receptor ROR-gamma Mus musculus 240 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382187&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669274 404851560 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764909 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCNCC1 InChI=1S/C27H26F8N2O3S/c28-19-3-5-20(6-4-19)41(39,40)24-11-14-37(23(38)16-9-12-36-13-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22,36H,1,8-14H2/t22-,24-/m1/s1 VPZRGOPJQVWEFS-ISKFKSNPSA-N 382190 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(piperidin-4-yl)methanone::US10273259, Example 6::US10711020, Example 6 Nuclear receptor ROR-gamma Mus musculus 257 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382190&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669042 404851563 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764910 OC(=O)c1ccc(cc1)S(=O)(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H19F8NO6S2/c28-18-4-8-19(9-5-18)43(39,40)24-11-12-36(44(41,42)20-6-1-15(2-7-20)23(37)38)22(24)14-16-13-17(3-10-21(16)24)25(29,26(30,31)32)27(33,34)35/h1-10,13,22H,11-12,14H2,(H,37,38) IBGCUPXNLBMSGE-UHFFFAOYSA-N 382191 4-((3a-((4-fluorophenyl)sulfonyl)-6-(perfluoropropan-2-yl)-3,3a,8,8a-tetrahydroindeno[2,1-b]pyrrol-1(2H)-yl)sulfonyl)benzoic acid::US10273259, Example 7 Nuclear receptor ROR-gamma Mus musculus 1033 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382191&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669284 404851564 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764911 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@]2([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H29F8NO5S/c32-20-3-5-21(6-4-20)46(44,45)28-15-16-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)23(28)8-1-18-17-19(2-7-22(18)28)29(33,30(34,35)36)31(37,38)39/h2-7,17,23H,1,8-16H2,(H,42,43)/t23-,26?,27?,28-/m0/s1 FLJYXIWKPNZXTJ-LWGYBYOHSA-N 382192 US10273259, Example 8::US10711020, Example 8 Nuclear receptor ROR-gamma Mus musculus 4277 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382192&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678634 404851565 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764912 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@]2([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h6-11,15-17,23H,1-5,12-14H2,(H,40,41)/t16-,17-,23-,26-/m0/s1 FEJZVGPREBSBIT-NOTBVDQOSA-N 382193 US10273259, Example 9::US10711020, Example 9 Nuclear receptor ROR-gamma Mus musculus 5354 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382193&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678940 404851566 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764913 Fc1ccc(cc1)S(=O)(=O)[C@]12CCN([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-11-12-36(23(37)16-9-13-42(38,39)14-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22H,1,8-14H2/t22-,24-/m0/s1 KJYXXEYJECOAQK-UPVQGACJSA-N 382194 US10273259, Example 10::US10711020, Example 10 Nuclear receptor ROR-gamma Mus musculus 8688 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382194&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678826 404851567 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764914 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-11-12-36(23(37)16-9-13-42(38,39)14-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22H,1,8-14H2/t22-,24-/m1/s1 KJYXXEYJECOAQK-ISKFKSNPSA-N 382195 US10273259, Example 11::US10711020, Example 11 Nuclear receptor ROR-gamma Mus musculus 107 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382195&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678562 404851568 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764915 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H29F8NO5S/c32-20-3-5-21(6-4-20)46(44,45)28-15-16-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)23(28)8-1-18-17-19(2-7-22(18)28)29(33,30(34,35)36)31(37,38)39/h2-7,17,23H,1,8-16H2,(H,42,43)/t23-,26?,27?,28-/m1/s1 FLJYXIWKPNZXTJ-LJJHVHFXSA-N 382198 US10273259, Example 12::US10711020, Example 12 Nuclear receptor ROR-gamma Mus musculus 118 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382198&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678563 404851571 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764916 CC(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O4S/c1-17(40)38-13-10-18(11-14-38)25(41)39-15-12-26(44(42,43)22-6-4-21(30)5-7-22)23-8-3-20(16-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,18,24H,2,9-15H2,1H3/t24-,26-/m1/s1 KRFUPWONDXEJMB-AOYPEHQESA-N 382201 US10273259, Example 13::US10711020, Example 13 Nuclear receptor ROR-gamma Mus musculus 144 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382201&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678748 404851574 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764917 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H27ClF7NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h6-11,15-17,23H,1-5,12-14H2,(H,40,41)/t16-,17-,23?,26? ASSZTGFDWPKORU-LRVXPCDCSA-N 382210 US10273259, Example 14::US10711020, Example 14 Nuclear receptor ROR-gamma Mus musculus 62.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382210&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669076 404851583 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764918 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C31H29ClF7NO5S/c32-20-3-5-21(6-4-20)46(44,45)28-15-16-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)23(28)8-1-18-17-19(2-7-22(18)28)29(33,30(34,35)36)31(37,38)39/h2-7,17,23H,1,8-16H2,(H,42,43) MXCMTPXIOAQXRW-UHFFFAOYSA-N 382213 US10273259, Example 15::US10711020, Example 15 Nuclear receptor ROR-gamma Mus musculus 185 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382213&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678636 404851586 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764919 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H25ClF7NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-11-12-36(23(37)16-9-13-42(38,39)14-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22H,1,8-14H2 NLPUXOGOYTUJOR-UHFFFAOYSA-N 382216 US10273259, Example 16::US10711020, Example 16 Nuclear receptor ROR-gamma Mus musculus 142 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382216&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678949 404851589 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764920 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H28ClF7N2O4S/c1-17(40)38-13-10-18(11-14-38)25(41)39-15-12-26(44(42,43)22-6-4-21(30)5-7-22)23-8-3-20(16-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,18,24H,2,9-15H2,1H3 YDMFQZHRZPJOTG-UHFFFAOYSA-N 382228 US10273259, Example 17::US10711020, Example 17 Nuclear receptor ROR-gamma Mus musculus 184 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382228&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678646 404851601 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764921 CC[C@@]1(CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(O)=O InChI=1S/C31H31ClF7NO5S/c1-2-27(26(42)43)13-11-18(12-14-27)25(41)40-16-15-28(46(44,45)22-7-5-21(32)6-8-22)23-9-4-20(17-19(23)3-10-24(28)40)29(33,30(34,35)36)31(37,38)39/h4-9,17-18,24H,2-3,10-16H2,1H3,(H,42,43)/t18-,24?,27-,28? NFBHREOTIAWPGV-GLMFJJLTSA-N 382231 US10273259, Example 18::US10711020, Example 18 Nuclear receptor ROR-gamma Mus musculus 189 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382231&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678637 404851604 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764922 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO5S/c1-17-2-10-22(11-3-17)44(42,43)27-14-15-38(25(39)18-4-6-19(7-5-18)26(40)41)24(27)13-8-20-16-21(9-12-23(20)27)28(31,29(32,33)34)30(35,36)37/h2-3,9-12,16,18-19,24H,4-8,13-15H2,1H3,(H,40,41)/t18-,19-,24?,27? JDFDTUYICUVLET-QXIWJBPRSA-N 382232 US10273259, Example 19::US10711020, Example 144 Nuclear receptor ROR-gamma Mus musculus 95.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382232&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678564 404851605 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764923 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F7NO5S/c1-19-2-6-22(7-3-19)46(44,45)29-16-17-40(25(41)27-10-13-28(14-11-27,15-12-27)26(42)43)24(29)9-4-20-18-21(5-8-23(20)29)30(33,31(34,35)36)32(37,38)39/h2-3,5-8,18,24H,4,9-17H2,1H3,(H,42,43) SNKGBBUIANWTAE-UHFFFAOYSA-N 382233 US10273259, Example 141::US10273259, Example 20::US10711020, Example 141 Nuclear receptor ROR-gamma Mus musculus 173 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382233&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678830 404851606 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764924 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H28F7NO5S2/c1-17-2-6-21(7-3-17)43(40,41)25-12-13-36(24(37)18-10-14-42(38,39)15-11-18)23(25)9-4-19-16-20(5-8-22(19)25)26(29,27(30,31)32)28(33,34)35/h2-3,5-8,16,18,23H,4,9-15H2,1H3 HUUCAOJGFRCTLB-UHFFFAOYSA-N 382234 US10273259, Example 21::US10711020, Example 21 Nuclear receptor ROR-gamma Mus musculus 244 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382234&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678565 404851607 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764925 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(C)cc1 InChI=1S/C30H31F7N2O4S/c1-18-3-7-23(8-4-18)44(42,43)27-13-16-39(26(41)20-11-14-38(15-12-20)19(2)40)25(27)10-5-21-17-22(6-9-24(21)27)28(31,29(32,33)34)30(35,36)37/h3-4,6-9,17,20,25H,5,10-16H2,1-2H3 JCYFRJDYEMDURJ-UHFFFAOYSA-N 382237 US10273259, Example 22::US10711020, Example 22 Nuclear receptor ROR-gamma Mus musculus 137 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382237&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678751 404851610 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764926 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO6S/c31-18-2-4-19(5-3-18)46(43,44)27-13-14-39(23(40)25-7-10-26(11-8-25,12-9-25)24(41)42)22(27)16-45-21-15-17(1-6-20(21)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22H,7-14,16H2,(H,41,42) BZZRJNNQLSEHON-UHFFFAOYSA-N 382238 US10273259, Example 23::US10711020, Example 23 Nuclear receptor ROR-gamma Mus musculus 88.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382238&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678846 404851611 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764927 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c1-16(39)37-11-8-17(9-12-37)24(40)38-13-10-25(44(41,42)20-5-3-19(29)4-6-20)21-7-2-18(14-22(21)43-15-23(25)38)26(30,27(31,32)33)28(34,35)36/h2-7,14,17,23H,8-13,15H2,1H3 IOJQPUUQUCLAAF-UHFFFAOYSA-N 382239 US10273259, Example 24::US10711020, Example 24 Nuclear receptor ROR-gamma Mus musculus 132 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382239&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678647 404851612 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764928 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H23F8NO6S2/c27-17-2-4-18(5-3-17)43(39,40)23-9-10-35(22(36)15-7-11-42(37,38)12-8-15)21(23)14-41-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 ZPONGLWUJBFKPH-UHFFFAOYSA-N 382240 US10273259, Example 25::US10711020, Example 33 Nuclear receptor ROR-gamma Mus musculus 152 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382240&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678847 404851613 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764929 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO6S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-43-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? USEIONJENDBBQE-QAXNPQHNSA-N 382241 US10273259, Example 26::US10711020, Example 26 Nuclear receptor ROR-gamma Mus musculus 100.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382241&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678639 404851614 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764930 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(I)ccc21)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C26H27ClINO5S/c27-19-6-9-21(10-7-19)35(33,34)26-13-14-29(24(30)16-1-3-17(4-2-16)25(31)32)23(26)12-5-18-15-20(28)8-11-22(18)26/h6-11,15-17,23H,1-5,12-14H2,(H,31,32)/t16-,17-,23?,26? HCRPMCCZKBAYDI-LRVXPCDCSA-N 382242 US10273259, Example 27::US10711020, Example 27 Nuclear receptor ROR-gamma Mus musculus 78.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382242&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669196 404851615 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764931 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1CCc1cc(I)ccc21)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C26H28ClIN2O4S/c1-17(31)29-13-10-18(11-14-29)25(32)30-15-12-26(35(33,34)22-6-3-20(27)4-7-22)23-8-5-21(28)16-19(23)2-9-24(26)30/h3-8,16,18,24H,2,9-15H2,1H3 FTNZAMXFFGTXMQ-UHFFFAOYSA-N 382243 US10273259, Example 28::US10711020, Example 28 Nuclear receptor ROR-gamma Mus musculus 155 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382243&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678763 404851616 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764932 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H28ClF6NO6S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-37(24(38)16-1-3-17(4-2-16)25(39)40)23(26)12-5-18-15-19(6-11-22(18)26)27(41,28(31,32)33)29(34,35)36/h6-11,15-17,23,41H,1-5,12-14H2,(H,39,40)/t16-,17-,23?,26? LRBGRUQIKSHSNG-LRVXPCDCSA-N 382244 US10273259, Example 29::US10711020, Example 29 Nuclear receptor ROR-gamma Mus musculus 330 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382244&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678760 404851617 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764933 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-39(24(40)18-10-12-26(31,13-11-18)25(41)42)23(27)9-4-19-16-20(5-8-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-3,5-8,16,18,23H,4,9-15H2,1H3,(H,41,42)/t18-,23?,26+,27? WPGVXUGXFMJDHZ-MJALUPOVSA-N 382247 US10273259, Example 31::US10711020, Example 31 Nuclear receptor ROR-gamma Mus musculus 81.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382247&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678955 404851620 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764934 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-39(25(42)26(31)12-10-18(11-13-26)24(40)41)23(27)9-4-19-16-20(5-8-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-3,5-8,16,18,23H,4,9-15H2,1H3,(H,40,41)/t18-,23?,26+,27? RWJCYGUITJAVMC-MJALUPOVSA-N 382248 US10273259, Example 32::US10711020, Example 145 Nuclear receptor ROR-gamma Mus musculus 199 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382248 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382248&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678757 404851621 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764935 OC(c1ccc2c(OCC3N(CCC23S(=O)(=O)c2ccc(F)cc2)C(=O)C2CCS(=O)(=O)CC2)c1)(C(F)(F)F)C(F)(F)F InChI=1S/C26H24F7NO7S2/c27-17-2-4-18(5-3-17)43(39,40)23-9-10-34(22(35)15-7-11-42(37,38)12-8-15)21(23)14-41-20-13-16(1-6-19(20)23)24(36,25(28,29)30)26(31,32)33/h1-6,13,15,21,36H,7-12,14H2 QTQQYHYAPWJWQP-UHFFFAOYSA-N 382249 US10273259, Example 33 Nuclear receptor ROR-gamma Mus musculus 290 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382249&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678643 404851622 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764936 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(I)ccc21)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H27FINO5S/c27-19-6-9-21(10-7-19)35(33,34)26-13-14-29(24(30)16-1-3-17(4-2-16)25(31)32)23(26)12-5-18-15-20(28)8-11-22(18)26/h6-11,15-17,23H,1-5,12-14H2,(H,31,32)/t16-,17-,23-,26-/m1/s1 LBVNOAQYAAENHP-NIULTJEISA-N 382250 US10273259, Example 34::US10711020, Example 34 Nuclear receptor ROR-gamma Mus musculus 75.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382250&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678638 404851623 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764937 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1ccccc21)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H28FNO5S/c27-20-10-12-21(13-11-20)34(32,33)26-15-16-28(23(26)14-9-17-3-1-2-4-22(17)26)24(29)18-5-7-19(8-6-18)25(30)31/h1-4,10-13,18-19,23H,5-9,14-16H2,(H,30,31)/t18-,19-,23?,26? DGTWLLIIGJFLFZ-XVFBROAMSA-N 382251 US10273259, Example 35::US10711020, Example 35 Nuclear receptor ROR-gamma Mus musculus 549 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382251&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678641 404851624 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764938 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F7NO7S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-36(23(37)15-1-3-16(4-2-15)24(38)39)22(25)14-43-21-13-17(5-10-20(21)25)26(40,27(30,31)32)28(33,34)35/h5-10,13,15-16,22,40H,1-4,11-12,14H2,(H,38,39)/t15-,16-,22?,25? IGNYNNABJSQDLQ-QAXNPQHNSA-N 382252 US10273259, Example 36::US10711020, Example 36 Nuclear receptor ROR-gamma Mus musculus 218 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382252&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678957 404851625 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764939 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1COc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F7NO7S/c31-18-2-4-19(5-3-18)46(43,44)27-13-14-38(23(39)25-7-10-26(11-8-25,12-9-25)24(40)41)22(27)16-45-21-15-17(1-6-20(21)27)28(42,29(32,33)34)30(35,36)37/h1-6,15,22,42H,7-14,16H2,(H,40,41) TWKHJFBPVIAUHN-UHFFFAOYSA-N 382253 US10273259, Example 37::US10711020, Example 37 Nuclear receptor ROR-gamma Mus musculus 2437 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382253&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678834 404851626 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764940 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F7NO6S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-37(24(38)16-1-3-17(4-2-16)25(39)40)23(26)12-5-18-15-19(6-11-22(18)26)27(41,28(31,32)33)29(34,35)36/h6-11,15-17,23,41H,1-5,12-14H2,(H,39,40)/t16-,17-,23-,26-/m1/s1 QTZGEDRMPXBKMK-NIULTJEISA-N 382254 US10273259, Example 38::US10711020, Example 38 Nuclear receptor ROR-gamma Mus musculus 5608 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382254&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678765 404851627 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764941 FC(F)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1 InChI=1S/C25H26ClF2NO5S2/c26-19-3-5-20(6-4-19)36(33,34)25-11-12-29(24(30)16-9-13-35(31,32)14-10-16)22(25)8-2-17-15-18(23(27)28)1-7-21(17)25/h1,3-7,15-16,22-23H,2,8-14H2 QQBKYQJWXADIBC-UHFFFAOYSA-N 382255 US10273259, Example 39 Nuclear receptor ROR-gamma Mus musculus 24.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382255&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995571 404851628 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764942 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H27ClF3NO5S/c28-20-7-9-21(10-8-20)38(36,37)26-13-14-32(24(33)16-1-3-17(4-2-16)25(34)35)23(26)12-5-18-15-19(27(29,30)31)6-11-22(18)26/h6-11,15-17,23H,1-5,12-14H2,(H,34,35)/t16-,17-,23?,26? BCJWUAOZGZZKDJ-LRVXPCDCSA-N 382258 US10273259, Example 40::US10711020, Example 40 Nuclear receptor ROR-gamma Mus musculus 62.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382258&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678979 404851631 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764943 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)-c1cccnc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H34N2O5S/c1-21-4-12-27(13-5-21)40(38,39)32-16-18-34(30(35)22-6-8-23(9-7-22)31(36)37)29(32)15-11-25-19-24(10-14-28(25)32)26-3-2-17-33-20-26/h2-5,10,12-14,17,19-20,22-23,29H,6-9,11,15-16,18H2,1H3,(H,36,37)/t22-,23-,29?,32? BMUOQNSHNPOGQV-DGJIIMRFSA-N 382261 US10273259, Example 41::US10711020, Example 41 Nuclear receptor ROR-gamma Mus musculus 336 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382261&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678767 404851634 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764944 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)-c1ccccc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C33H35NO5S/c1-22-7-15-28(16-8-22)40(38,39)33-19-20-34(31(35)24-9-11-25(12-10-24)32(36)37)30(33)18-14-27-21-26(13-17-29(27)33)23-5-3-2-4-6-23/h2-8,13,15-17,21,24-25,30H,9-12,14,18-20H2,1H3,(H,36,37)/t24-,25-,30?,33? ZJTHUPANPJPSLK-DERABLCZSA-N 382264 US10273259, Example 42::US10711020, Example 42 Nuclear receptor ROR-gamma Mus musculus 186 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382264&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678959 404851637 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764945 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO5S/c1-18-3-7-22(8-4-18)45(43,44)28-15-16-39(26(42)27(2)13-11-19(12-14-27)25(40)41)24(28)10-5-20-17-21(6-9-23(20)28)29(32,30(33,34)35)31(36,37)38/h3-4,6-9,17,19,24H,5,10-16H2,1-2H3,(H,40,41)/t19-,24?,27-,28? ASMKMWWMAPJCNU-XJNMGFQWSA-N 382265 US10273259, Example 43::US10711020, Example 43 Nuclear receptor ROR-gamma Mus musculus 421 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382265&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678837 404851638 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764946 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H26ClF6NO7S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-36(23(37)15-1-3-16(4-2-15)24(38)39)22(25)14-43-21-13-17(5-10-20(21)25)26(40,27(30,31)32)28(33,34)35/h5-10,13,15-16,22,40H,1-4,11-12,14H2,(H,38,39)/t15-,16-,22?,25? DXAZIJICDSJYBW-QAXNPQHNSA-N 382266 US10273259, Example 44::US10711020, Example 44 Nuclear receptor ROR-gamma Mus musculus 138 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382266&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678770 404851639 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764947 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H28ClF6NO6S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-37(24(38)16-4-6-17(7-5-16)25(39)40)23(26)11-8-18-14-19(9-10-22(18)26)27(41,28(31,32)33)29(34,35)36/h1-3,9-10,14-17,23,41H,4-8,11-13H2,(H,39,40)/t16-,17-,23?,26? GXNYATPJZKFFFV-LRVXPCDCSA-N 382267 US10273259, Example 45::US10711020, Example 45 Nuclear receptor ROR-gamma Mus musculus 138 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382267&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678642 404851640 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764948 FC(F)(F)C(F)(c1ccc2c(OCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO6S2/c27-17-2-4-18(5-3-17)43(39,40)23-9-10-35(22(36)15-7-11-42(37,38)12-8-15)21(23)14-41-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 VVPMBXSVZJBHEX-UHFFFAOYSA-N 382272 US10273259, Example 46::US10711020, Example 46 Nuclear receptor ROR-gamma Mus musculus 111 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382272&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678567 404851645 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764949 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H25ClF7NO6S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-43-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? VCXVCISBJCUPPR-QAXNPQHNSA-N 382276 US10273259, Example 47::US10711020, Example 47 Nuclear receptor ROR-gamma Mus musculus 130 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382276&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678962 404851649 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764950 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H26ClF7N2O5S/c1-16(39)37-11-8-17(9-12-37)24(40)38-13-10-25(44(41,42)20-5-3-19(29)4-6-20)21-7-2-18(14-22(21)43-15-23(25)38)26(30,27(31,32)33)28(34,35)36/h2-7,14,17,23H,8-13,15H2,1H3 UYNWLHITYFAZRB-UHFFFAOYSA-N 382279 US10273259, Example 48::US10711020, Example 48 Nuclear receptor ROR-gamma Mus musculus 30.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382279&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678652 404851652 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764951 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H28F7NO5S/c30-27(28(31,32)33,29(34,35)36)20-11-12-22-19(16-20)10-13-23-26(22,43(41,42)21-4-2-1-3-5-21)14-15-37(23)24(38)17-6-8-18(9-7-17)25(39)40/h1-5,11-12,16-18,23H,6-10,13-15H2,(H,39,40)/t17-,18-,23-,26-/m1/s1 SXKKMGOPECZXNY-JJMBJGOUSA-N 382280 US10273259, Example 49::US10711020, Example 49 Nuclear receptor ROR-gamma Mus musculus 59.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382280&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678983 404851653 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765748 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H28ClF7N2O6S2/c1-2-37-16-22-25(46(43,44)19-6-4-18(29)5-7-19,9-12-38(22)23(39)24(40)10-13-45(41,42)14-11-24)20-8-3-17(15-21(20)37)26(30,27(31,32)33)28(34,35)36/h3-8,15,22,40H,2,9-14,16H2,1H3 OCYMAQYQLMOGHB-UHFFFAOYSA-N 383138 US10273259, Example 849::US10711020, Example 849 Nuclear receptor ROR-gamma Mus musculus 616 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383138&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679200 404852434 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765749 FC(F)(F)C(F)(c1ccc2c(CC[C@H]3N(CC[C@@]23S(=O)(=O)c2ccccc2)C(=O)CN2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H27F7N2O5S2/c28-25(26(29,30)31,27(32,33)34)19-7-8-21-18(16-19)6-9-22-24(21,43(40,41)20-4-2-1-3-5-20)10-11-36(22)23(37)17-35-12-14-42(38,39)15-13-35/h1-5,7-8,16,22H,6,9-15,17H2/t22-,24-/m1/s1 DOMKFIOVSXNRFY-ISKFKSNPSA-N 383139 US10273259, Example 850::US10711020, Example 850 Nuclear receptor ROR-gamma Mus musculus 274 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383139&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679300 404852435 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765750 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2nncn2c1 InChI=1S/C28H20F8N4O3S/c29-19-4-6-20(7-5-19)44(42,43)25-11-12-40(24(41)17-2-10-23-38-37-15-39(23)14-17)22(25)9-1-16-13-18(3-8-21(16)25)26(30,27(31,32)33)28(34,35)36/h2-8,10,13-15,22H,1,9,11-12H2/t22-,25-/m1/s1 HXWJDULVVNUERD-RCZVLFRGSA-N 383140 US10273259, Example 851::US10711020, Example 851 Nuclear receptor ROR-gamma Mus musculus 357 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383140&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679204 404852436 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765751 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)c2ccc3nncn3c2)c1)C(F)(F)F InChI=1S/C28H20ClF7N4O3S/c29-19-4-6-20(7-5-19)44(42,43)25-11-12-40(24(41)17-2-10-23-38-37-15-39(23)14-17)22(25)9-1-16-13-18(3-8-21(16)25)26(30,27(31,32)33)28(34,35)36/h2-8,10,13-15,22H,1,9,11-12H2 RQAFFTNZQNZEDK-UHFFFAOYSA-N 383141 US10273259, Example 852::US10711020, Example 852 Nuclear receptor ROR-gamma Mus musculus 317 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383141&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679268 404852437 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765752 CC(=O)N1CCN(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CC1 InChI=1S/C29H29F8N3O4S/c1-18(41)39-14-12-38(13-15-39)17-25(42)40-11-10-26(45(43,44)22-6-4-21(30)5-7-22)23-8-3-20(16-19(23)2-9-24(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,16,24H,2,9-15,17H2,1H3/t24-,26-/m1/s1 XRIKHAWQAIQWFH-AOYPEHQESA-N 383142 US10273259, Example 853::US10711020, Example 853 Nuclear receptor ROR-gamma Mus musculus 176 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383142&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679279 404852438 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765753 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(F)c1 InChI=1S/C27H24F9NO6S2/c28-19-5-3-17(14-20(19)29)45(42,43)24-7-10-37(22(38)23(39)8-11-44(40,41)12-9-23)21(24)6-1-15-13-16(2-4-18(15)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-14,21,39H,1,6-12H2 NDHMELMUEHGMOW-UHFFFAOYSA-N 383143 US10273259, Example 854::US10711020, Example 854 Nuclear receptor ROR-gamma Mus musculus 110 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383143&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679269 404852439 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765754 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(F)c1 InChI=1S/C29H26F9NO5S/c30-21-9-7-19(14-22(21)31)45(43,44)26-11-12-39(24(40)15-1-3-16(4-2-15)25(41)42)23(26)10-5-17-13-18(6-8-20(17)26)27(32,28(33,34)35)29(36,37)38/h6-9,13-16,23H,1-5,10-12H2,(H,41,42)/t15-,16-,23?,26? WQYJSKOPDWCZGC-KMLPXHMCSA-N 383144 US10273259, Example 855::US10711020, Example 855 Nuclear receptor ROR-gamma Mus musculus 92.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383144&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679288 404852440 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765755 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1noc(=O)[nH]1 383145 US10273259, Example 856::US10711020, Example 856 Nuclear receptor ROR-gamma Mus musculus 4434 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383145&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995618 404852441 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765756 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H26ClF7N2O5S2/c1-36-15-22-24(44(41,42)19-5-3-18(28)4-6-19,10-11-37(22)23(38)16-8-12-43(39,40)13-9-16)20-7-2-17(14-21(20)36)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,8-13,15H2,1H3 KXBOUMSMUPGJDE-UHFFFAOYSA-N 383146 US10273259, Example 857::US10711020, Example 857 Nuclear receptor ROR-gamma Mus musculus 229 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383146&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678820 404852442 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765757 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N(C1CC1)C1CCOCC1 InChI=1S/C30H30F8N2O4S/c31-20-3-7-23(8-4-20)45(42,43)27-13-14-39(26(41)40(21-5-6-21)22-11-15-44-16-12-22)25(27)10-1-18-17-19(2-9-24(18)27)28(32,29(33,34)35)30(36,37)38/h2-4,7-9,17,21-22,25H,1,5-6,10-16H2/t25-,27-/m1/s1 ABIMSIIZXHTHEA-XNMGPUDCSA-N 383147 US10273259, Example 858::US10711020, Example 858 Nuclear receptor ROR-gamma Mus musculus 305 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383147&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679214 404852443 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765758 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C27H26ClF7N2O6S2/c1-36-15-21-24(45(42,43)18-5-3-17(28)4-6-18,8-11-37(21)22(38)23(39)9-12-44(40,41)13-10-23)19-7-2-16(14-20(19)36)25(29,26(30,31)32)27(33,34)35/h2-7,14,21,39H,8-13,15H2,1H3 WTTWCNKDMVOPCF-UHFFFAOYSA-N 383148 US10273259, Example 859::US10711020, Example 859 Nuclear receptor ROR-gamma Mus musculus 114 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383148&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679181 404852444 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765759 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)c2noc(=O)[nH]2)c1)C(F)(F)F 383149 US10273259, Example 860::US10711020, Example 860 Nuclear receptor ROR-gamma Mus musculus 6301 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383149&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995619 404852445 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765760 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCOCC1 InChI=1S/C26H24F8N2O4S/c27-18-3-5-19(6-4-18)41(38,39)23-9-10-36(22(37)35-11-13-40-14-12-35)21(23)8-1-16-15-17(2-7-20(16)23)24(28,25(29,30)31)26(32,33)34/h2-7,15,21H,1,8-14H2/t21-,23-/m1/s1 ASRNEDSRHDLYMM-FYYLOGMGSA-N 383150 US10273259, Example 861::US10711020, Example 861 Nuclear receptor ROR-gamma Mus musculus 296 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383150&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679198 404852446 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765761 C[C@H]1C[C@H](CC[C@@H]1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-18(26(41)42)2-9-22(16)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18-,22-,24+,27+/m0/s1 JQORWGARJVSRBA-QVIYERQUSA-N 383151 US10273259, Example 862::US10711020, Example 862 Nuclear receptor ROR-gamma Mus musculus 158 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383151&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678852 404852447 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765762 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCC(=O)N1CCC#N InChI=1S/C29H25F8N3O4S/c30-19-4-6-20(7-5-19)45(43,44)26-12-15-40(25(42)22-9-11-24(41)39(22)14-1-13-38)23(26)10-2-17-16-18(3-8-21(17)26)27(31,28(32,33)34)29(35,36)37/h3-8,16,22-23H,1-2,9-12,14-15H2/t22-,23+,26+/m0/s1 XDDWLXGEQFTMIY-PPJWLVRDSA-N 383152 US10273259, Example 863::US10711020, Example 863 Nuclear receptor ROR-gamma Mus musculus 79.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383152&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679209 404852448 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765763 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCOCC11NC(=O)NC1=O InChI=1S/C29H26F8N4O6S/c30-17-3-5-18(6-4-17)48(45,46)26-10-11-41(24(44)38-20-9-12-47-14-25(20)22(42)39-23(43)40-25)21(26)8-1-15-13-16(2-7-19(15)26)27(31,28(32,33)34)29(35,36)37/h2-7,13,20-21H,1,8-12,14H2,(H,38,44)(H2,39,40,42,43)/t20?,21-,25?,26-/m1/s1 DAEFFTAFHRYSFX-AXOKKOEUSA-N 383153 US10273259, Example 864::US10711020, Example 864 Nuclear receptor ROR-gamma Mus musculus 131 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383153&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123847 404852449 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765764 OC(=O)C1(CCS(=O)(=O)CC1)NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O7S2/c29-18-3-5-19(6-4-18)47(44,45)25-9-12-38(23(41)37-24(22(39)40)10-13-46(42,43)14-11-24)21(25)8-1-16-15-17(2-7-20(16)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,21H,1,8-14H2,(H,37,41)(H,39,40)/t21-,25-/m1/s1 ZGQZBKNYGHOIRE-PXDATVDWSA-N 383154 US10273259, Example 865::US10711020, Example 865 Nuclear receptor ROR-gamma Mus musculus 86.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383154&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679271 404852450 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765765 F[C@H]1C[C@H](N(CCC#N)C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F9N3O3S/c30-19-4-6-21(7-5-19)45(43,44)26-10-13-41(25(42)23-15-20(31)16-40(23)12-1-11-39)24(26)9-2-17-14-18(3-8-22(17)26)27(32,28(33,34)35)29(36,37)38/h3-8,14,20,23-24H,1-2,9-10,12-13,15-16H2/t20-,23-,24+,26+/m0/s1 RDAKGQRSCIXLRS-ZUDIISFQSA-N 383155 US10273259, Example 866::US10711020, Example 866 Nuclear receptor ROR-gamma Mus musculus 547 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383155&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679182 404852451 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765766 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C31H28Cl2F7NO5S/c32-21-5-3-19(16-22(21)33)47(45,46)28-13-14-41(24(42)26-7-10-27(11-8-26,12-9-26)25(43)44)23(28)6-1-17-15-18(2-4-20(17)28)29(34,30(35,36)37)31(38,39)40/h2-5,15-16,23H,1,6-14H2,(H,43,44) GWCNASWFBUUXFB-UHFFFAOYSA-N 383156 US10273259, Example 867::US10711020, Example 867 Nuclear receptor ROR-gamma Mus musculus 318 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383156&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679191 404852452 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765767 CC(C)C(N(C1CCS(=O)(=O)C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C31H32F8N2O7S2/c1-17(2)25(26(42)43)41(21-11-14-49(45,46)16-21)27(44)40-13-12-28(50(47,48)22-7-5-20(32)6-8-22)23-9-4-19(15-18(23)3-10-24(28)40)29(33,30(34,35)36)31(37,38)39/h4-9,15,17,21,24-25H,3,10-14,16H2,1-2H3,(H,42,43)/t21?,24-,25?,28-/m1/s1 MYKUEHYCCDSATF-LNGFBGLASA-N 383157 US10273259, Example 868 Nuclear receptor ROR-gamma Mus musculus 278 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383157&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679311 404852453 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765768 CN1[C@@H](CCCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-37-21(3-2-4-23(37)39)24(40)38-14-13-25(43(41,42)19-9-7-18(29)8-10-19)20-11-6-17(15-16(20)5-12-22(25)38)26(30,27(31,32)33)28(34,35)36/h6-11,15,21-22H,2-5,12-14H2,1H3/t21-,22+,25+/m0/s1 MFQXWARSIFLBTN-SGIRGMQISA-N 383158 US10273259, Example 869::US10711020, Example 869 Nuclear receptor ROR-gamma Mus musculus 292 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383158&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679285 404852454 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765769 F[C@H]1C[C@H](N(CC#N)C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F9N3O3S/c29-18-3-5-20(6-4-18)44(42,43)25-9-11-40(24(41)22-14-19(30)15-39(22)12-10-38)23(25)8-1-16-13-17(2-7-21(16)25)26(31,27(32,33)34)28(35,36)37/h2-7,13,19,22-23H,1,8-9,11-12,14-15H2/t19-,22-,23+,25+/m0/s1 TXBQKEMSHREZLN-KNEWOZPHSA-N 383159 US10273259, Example 870::US10711020, Example 870 Nuclear receptor ROR-gamma Mus musculus 162 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383159&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679199 404852455 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765770 CC(=O)N[C@@H]1CS(=O)(=O)C[C@H]1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8N3O6S2/c1-15(40)37-21-13-46(42,43)14-22(21)38-24(41)39-11-10-25(47(44,45)19-6-4-18(29)5-7-19)20-8-3-17(12-16(20)2-9-23(25)39)26(30,27(31,32)33)28(34,35)36/h3-8,12,21-23H,2,9-11,13-14H2,1H3,(H,37,40)(H,38,41)/t21-,22-,23-,25-/m1/s1 OTXBJQBFLDNACM-VWBWNGLSSA-N 383160 US10273259, Example 871::US10711020, Example 871 Nuclear receptor ROR-gamma Mus musculus 215 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383160&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679296 404852456 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765771 Fc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H24ClF8NO5S2/c28-20-14-18(3-5-21(20)29)44(41,42)24-9-10-37(23(38)15-7-11-43(39,40)12-8-15)22(24)6-1-16-13-17(2-4-19(16)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-15,22H,1,6-12H2 HUJUOPROJGBEFI-UHFFFAOYSA-N 383161 US10273259, Example 872::US10711020, Example 872 Nuclear receptor ROR-gamma Mus musculus 226 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383161&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678968 404852457 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765772 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(Cl)c1 InChI=1S/C27H24ClF8NO6S2/c28-19-14-17(3-5-20(19)29)45(42,43)24-7-10-37(22(38)23(39)8-11-44(40,41)12-9-23)21(24)6-1-15-13-16(2-4-18(15)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-14,21,39H,1,6-12H2 VZPXZYRWMQOUAG-UHFFFAOYSA-N 383162 US10273259, Example 873::US10711020, Example 873 Nuclear receptor ROR-gamma Mus musculus 193 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383162&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679291 404852458 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765773 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H28ClF7N2O5S/c31-18-2-4-19(5-3-18)46(44,45)27-13-14-40(23(41)25-7-10-26(11-8-25,12-9-25)24(42)43)22(27)16-39-21-15-17(1-6-20(21)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22,39H,7-14,16H2,(H,42,43) DCOSMVLSMKCHGD-UHFFFAOYSA-N 383163 US10273259, Example 874::US10711020, Example 874 Nuclear receptor ROR-gamma Mus musculus 423 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383163&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678925 404852459 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765774 CS(=O)(=O)N1CCN(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CC1 InChI=1S/C28H29F8N3O5S2/c1-45(41,42)38-14-12-37(13-15-38)17-24(40)39-11-10-25(46(43,44)21-6-4-20(29)5-7-21)22-8-3-19(16-18(22)2-9-23(25)39)26(30,27(31,32)33)28(34,35)36/h3-8,16,23H,2,9-15,17H2,1H3/t23-,25-/m1/s1 FNWNKMCQLZXHJH-ILBGXUMGSA-N 383164 US10273259, Example 875::US10711020, Example 875 Nuclear receptor ROR-gamma Mus musculus 169 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383164&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678828 404852460 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765775 CC(=O)NC1CS(=O)(=O)CCC1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O6S2/c1-16(41)38-23-15-47(43,44)13-10-22(23)39-25(42)40-12-11-26(48(45,46)20-6-4-19(30)5-7-20)21-8-3-18(14-17(21)2-9-24(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,14,22-24H,2,9-13,15H2,1H3,(H,38,41)(H,39,42)/t22?,23?,24-,26-/m1/s1 UMHRTWJGSIYIHV-SFASGRJPSA-N 383165 US10273259, Example 876::US10273259, Example 878::US10711020, Example 878 Nuclear receptor ROR-gamma Mus musculus 158 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383165&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678844 404852461 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765776 CC(C)(O)CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F9N2O5S/c1-26(2,44)15-41-22(14-21(32)24(41)42)25(43)40-12-11-27(47(45,46)19-7-5-18(31)6-8-19)20-9-4-17(13-16(20)3-10-23(27)40)28(33,29(34,35)36)30(37,38)39/h4-9,13,21-23,44H,3,10-12,14-15H2,1-2H3/t21-,22-,23+,27+/m0/s1 NETWYXYMXZLUOG-OJXRJRMYSA-N 383166 US10273259, Example 877::US10711020, Example 877 Nuclear receptor ROR-gamma Mus musculus 300 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383166&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678876 404852462 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765777 CC(=O)NC1CS(=O)(=O)CCC1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O6S2/c1-16(41)38-23-15-47(43,44)13-10-22(23)39-25(42)40-12-11-26(48(45,46)20-6-4-19(30)5-7-20)21-8-3-18(14-17(21)2-9-24(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,14,22-24H,2,9-13,15H2,1H3,(H,38,41)(H,39,42)/t22?,23?,24-,26-/m1/s1 UMHRTWJGSIYIHV-SFASGRJPSA-N 383165 US10273259, Example 876::US10273259, Example 878::US10711020, Example 878 Nuclear receptor ROR-gamma Mus musculus 172 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383165&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678844 404852461 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765778 CN(CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C1CCS(=O)(=O)C1 InChI=1S/C28H28F8N2O5S2/c1-37(20-10-13-44(40,41)16-20)15-24(39)38-12-11-25(45(42,43)21-6-4-19(29)5-7-21)22-8-3-18(14-17(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,14,20,23H,2,9-13,15-16H2,1H3/t20?,23-,25-/m1/s1 RAUACNVWKWOTAA-ALRSMIOZSA-N 383168 US10273259, Example 879::US10711020, Example 879 Nuclear receptor ROR-gamma Mus musculus 256 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383168&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123796 404852463 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765779 Cc1ccc(cc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-2-9-21(15-23(16)31)45(43,44)27-12-13-39(25(40)17-3-5-18(6-4-17)26(41)42)24(27)11-7-19-14-20(8-10-22(19)27)28(32,29(33,34)35)30(36,37)38/h2,8-10,14-15,17-18,24H,3-7,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? PDGKINUZZURWRV-VRSFHCCXSA-N 383169 US10273259, Example 880::US10711020, Example 880 Nuclear receptor ROR-gamma Mus musculus 382 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383169&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679210 404852464 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765780 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C31H30ClF7N2O5S/c1-40-17-23-28(47(45,46)20-5-3-19(32)4-6-20,21-7-2-18(16-22(21)40)29(33,30(34,35)36)31(37,38)39)14-15-41(23)24(42)26-8-11-27(12-9-26,13-10-26)25(43)44/h2-7,16,23H,8-15,17H2,1H3,(H,43,44) HQOWOHXMRYGROC-UHFFFAOYSA-N 383170 US10273259, Example 881::US10711020, Example 881 Nuclear receptor ROR-gamma Mus musculus 191 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383170&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679221 404852465 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765781 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)[C@@H]2CCC(=O)N2CCC#N)c1)C(F)(F)F InChI=1S/C29H25ClF7N3O4S/c30-19-4-6-20(7-5-19)45(43,44)26-12-15-40(25(42)22-9-11-24(41)39(22)14-1-13-38)23(26)10-2-17-16-18(3-8-21(17)26)27(31,28(32,33)34)29(35,36)37/h3-8,16,22-23H,1-2,9-12,14-15H2/t22-,23?,26?/m0/s1 HSVGOEREHCXCOP-MFNHVEPQSA-N 383171 US10273259, Example 882::US10711020, Example 882 Nuclear receptor ROR-gamma Mus musculus 135 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383171&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678974 404852466 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765782 CN1[C@@H](C[C@H](O)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H24ClF7N2O5S/c1-36-19(13-20(38)23(36)40)22(39)37-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,19-21,38H,2,9-11,13H2,1H3/t19-,20-,21?,24?/m0/s1 XQJNUGSGRULWKH-SZYSUKIFSA-N 383172 US10273259, Example 883::US10711020, Example 883 Nuclear receptor ROR-gamma Mus musculus 201 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383172&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995620 404852467 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765783 CO[C@H]1C[C@H](N(C)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H26ClF7N2O5S/c1-37-20(14-21(43-2)24(37)40)23(39)38-12-11-25(44(41,42)18-7-5-17(29)6-8-18)19-9-4-16(13-15(19)3-10-22(25)38)26(30,27(31,32)33)28(34,35)36/h4-9,13,20-22H,3,10-12,14H2,1-2H3/t20-,21-,22?,25?/m0/s1 YCJWBWOKWUXKGO-GFOXRHNOSA-N 383173 US10273259, Example 884::US10711020, Example 884 Nuclear receptor ROR-gamma Mus musculus 477 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383173&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995621 404852468 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765784 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C=O InChI=1S/C28H26F8N2O4S/c29-20-3-5-21(6-4-20)43(41,42)25-11-14-38(24(40)17-9-12-37(16-39)13-10-17)23(25)8-1-18-15-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,15-17,23H,1,8-14H2/t23-,25-/m1/s1 JDBYOVCVWRGARG-ILBGXUMGSA-N 383174 US10273259, Example 885::US10711020, Example 885 Nuclear receptor ROR-gamma Mus musculus 167 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383174&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679283 404852469 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764952 CC(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H29F7N2O4S/c1-18(39)37-14-11-19(12-15-37)25(40)38-16-13-26(43(41,42)22-5-3-2-4-6-22)23-9-8-21(17-20(23)7-10-24(26)38)27(30,28(31,32)33)29(34,35)36/h2-6,8-9,17,19,24H,7,10-16H2,1H3/t24-,26-/m1/s1 LSGPKMNRHVPCGC-AOYPEHQESA-N 382282 US10273259, Example 50::US10711020, Example 50 Nuclear receptor ROR-gamma Mus musculus 53.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382282&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678653 404851655 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764953 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F7NO6S/c1-16-2-9-20(10-3-16)44(41,42)26-12-13-37(24(38)17-4-6-18(7-5-17)25(39)40)23(26)15-43-22-14-19(8-11-21(22)26)27(30,28(31,32)33)29(34,35)36/h2-3,8-11,14,17-18,23H,4-7,12-13,15H2,1H3,(H,39,40)/t17-,18-,23?,26? DCHVBHWKUXXLNW-GIHSMNABSA-N 382285 US10273259, Example 51::US10711020, Example 51 Nuclear receptor ROR-gamma Mus musculus 85.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382285&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678964 404851658 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764954 CC(=O)N1CCC(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(C)cc1 InChI=1S/C29H29F7N2O5S/c1-17-3-6-21(7-4-17)44(41,42)26-11-14-38(25(40)19-9-12-37(13-10-19)18(2)39)24(26)16-43-23-15-20(5-8-22(23)26)27(30,28(31,32)33)29(34,35)36/h3-8,15,19,24H,9-14,16H2,1-2H3 XOHJXPICJBVWHF-UHFFFAOYSA-N 382286 US10273259, Example 52 Nuclear receptor ROR-gamma Mus musculus 73.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382286&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678965 404851659 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764955 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H26F7NO6S2/c1-16-2-5-19(6-3-16)43(39,40)24-10-11-35(23(36)17-8-12-42(37,38)13-9-17)22(24)15-41-21-14-18(4-7-20(21)24)25(28,26(29,30)31)27(32,33)34/h2-7,14,17,22H,8-13,15H2,1H3 RWYKCRQSSRVCFK-UHFFFAOYSA-N 382287 US10273259, Example 53::US10711020, Example 53 Nuclear receptor ROR-gamma Mus musculus 121 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382287&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678570 404851660 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764956 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C31H30F7NO5S/c32-29(30(33,34)35,31(36,37)38)20-7-8-22-19(18-20)6-9-23-28(22,45(43,44)21-4-2-1-3-5-21)16-17-39(23)24(40)26-10-13-27(14-11-26,15-12-26)25(41)42/h1-5,7-8,18,23H,6,9-17H2,(H,41,42)/t23-,26?,27?,28-/m1/s1 QHFAQHDZLWBIGL-LJJHVHFXSA-N 382288 US10273259, Example 54 Nuclear receptor ROR-gamma Mus musculus 60.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382288&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678842 404851661 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764957 FC(F)(F)C(F)(c1ccc2c(CC[C@H]3N(CC[C@@]23S(=O)(=O)c2ccccc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H26F7NO5S2/c28-25(26(29,30)31,27(32,33)34)19-7-8-21-18(16-19)6-9-22-24(21,42(39,40)20-4-2-1-3-5-20)12-13-35(22)23(36)17-10-14-41(37,38)15-11-17/h1-5,7-8,16-17,22H,6,9-15H2/t22-,24-/m1/s1 QFANYMMGAGSSKB-ISKFKSNPSA-N 382290 US10273259, Example 55::US10711020, Example 55 Nuclear receptor ROR-gamma Mus musculus 60.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382290&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678573 404851663 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764958 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H28F7NO6S/c30-27(28(31,32)33,29(34,35)36)19-7-8-21-18(16-19)6-9-22-26(21,44(42,43)20-4-2-1-3-5-20)14-15-37(22)24(40)25(41)12-10-17(11-13-25)23(38)39/h1-5,7-8,16-17,22,41H,6,9-15H2,(H,38,39)/t17-,22-,25+,26-/m1/s1 WSLUKAWNPCTYDQ-FQQZQYMPSA-N 382293 US10273259, Example 56::US10711020, Example 79 Nuclear receptor ROR-gamma Mus musculus 183 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382293&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678855 404851666 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764959 C[C@@]1(CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(O)=O InChI=1S/C30H30F7NO5S/c1-26(25(40)41)13-11-18(12-14-26)24(39)38-16-15-27(44(42,43)21-5-3-2-4-6-21)22-9-8-20(17-19(22)7-10-23(27)38)28(31,29(32,33)34)30(35,36)37/h2-6,8-9,17-18,23H,7,10-16H2,1H3,(H,40,41)/t18-,23-,26-,27-/m1/s1 JCWKZEXJYWCBFY-SRWMLJHBSA-N 382298 US10273259, Example 57::US10711020, Example 57 Nuclear receptor ROR-gamma Mus musculus 49.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382298&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678575 404851671 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764960 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C30H30F7NO5S/c1-26(13-11-18(12-14-26)24(39)40)25(41)38-16-15-27(44(42,43)21-5-3-2-4-6-21)22-9-8-20(17-19(22)7-10-23(27)38)28(31,29(32,33)34)30(35,36)37/h2-6,8-9,17-18,23H,7,10-16H2,1H3,(H,39,40)/t18-,23-,26-,27-/m1/s1 MVXCZYDDJZYFRS-SRWMLJHBSA-N 382311 US10273259, Example 58::US10711020, Example 58 Nuclear receptor ROR-gamma Mus musculus 85.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382311&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678851 404851684 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764961 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C31H30F7NO6S/c1-18-2-5-20(6-3-18)46(43,44)28-14-15-39(24(40)26-8-11-27(12-9-26,13-10-26)25(41)42)23(28)17-45-22-16-19(4-7-21(22)28)29(32,30(33,34)35)31(36,37)38/h2-7,16,23H,8-15,17H2,1H3,(H,41,42) HUEROKBEJHSLGM-UHFFFAOYSA-N 382326 US10273259, Example 59::US10711020, Example 59 Nuclear receptor ROR-gamma Mus musculus 103 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382326&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678990 404851698 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764962 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO6S/c1-17-3-6-20(7-4-17)45(42,43)27-13-14-38(25(41)26(2)11-9-18(10-12-26)24(39)40)23(27)16-44-22-15-19(5-8-21(22)27)28(31,29(32,33)34)30(35,36)37/h3-8,15,18,23H,9-14,16H2,1-2H3,(H,39,40)/t18-,23?,26-,27? DZOCEMKCRHLMQC-OTZBKSJOSA-N 382327 US10273259, Example 60::US10711020, Example 60 Nuclear receptor ROR-gamma Mus musculus 71.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382327&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678585 404851699 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764963 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F7NO7S/c1-16-2-5-19(6-3-16)45(42,43)26-12-13-37(24(40)25(41)10-8-17(9-11-25)23(38)39)22(26)15-44-21-14-18(4-7-20(21)26)27(30,28(31,32)33)29(34,35)36/h2-7,14,17,22,41H,8-13,15H2,1H3,(H,38,39)/t17-,22?,25+,26? GPUPCDORHIMSOQ-ZZDDDDRDSA-N 382340 US10273259, Example 61::US10711020, Example 61 Nuclear receptor ROR-gamma Mus musculus 454 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382340&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678992 404851712 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764964 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H27ClF5NO5S/c29-20-7-9-21(10-8-20)41(39,40)26-13-14-35(24(36)16-1-3-17(4-2-16)25(37)38)23(26)12-5-18-15-19(6-11-22(18)26)27(30,31)28(32,33)34/h6-11,15-17,23H,1-5,12-14H2,(H,37,38)/t16-,17-,23?,26? ANYBAOLPXYZVBK-LRVXPCDCSA-N 382342 US10273259, Example 62 Nuclear receptor ROR-gamma Mus musculus 33.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382342&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123468 404851714 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764965 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H27ClF7NO6S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-38(24(41)25(42)11-9-16(10-12-25)23(39)40)22(26)8-1-17-15-18(2-7-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-7,15-16,22,42H,1,8-14H2,(H,39,40)/t16-,22?,25+,26? TYAAJBCLFWLEPD-VXBFRIGJSA-N 382345 US10273259, Example 63::US10711020, Example 63 Nuclear receptor ROR-gamma Mus musculus 21.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382345&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678774 404851717 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764966 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H29ClF7NO5S/c1-26(12-10-17(11-13-26)24(40)41)25(42)39-15-14-27(45(43,44)21-6-4-20(31)5-7-21)22-8-3-19(16-18(22)2-9-23(27)39)28(32,29(33,34)35)30(36,37)38/h3-8,16-17,23H,2,9-15H2,1H3,(H,40,41)/t17-,23?,26-,27? XBWBETBJTIWXIV-PYPIJRSMSA-N 382352 US10273259, Example 65::US10711020, Example 65 Nuclear receptor ROR-gamma Mus musculus 58.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382352&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678988 404851724 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764967 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-26(12-10-17(11-13-26)24(40)41)25(42)39-15-14-27(45(43,44)21-6-4-20(31)5-7-21)22-8-3-19(16-18(22)2-9-23(27)39)28(32,29(33,34)35)30(36,37)38/h3-8,16-17,23H,2,9-15H2,1H3,(H,40,41)/t17-,23-,26-,27-/m1/s1 IFTFEJQRBOPQKV-ZKPUSUNFSA-N 382353 US10273259, Example 66::US10711020, Example 66 Nuclear receptor ROR-gamma Mus musculus 54.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382353&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669103 404851725 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764968 CC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-24(11-14-43(39,40)15-12-24)23(38)37-13-10-25(44(41,42)20-6-4-19(29)5-7-20)21-8-3-18(16-17(21)2-9-22(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,16,22H,2,9-15H2,1H3/t22-,25-/m1/s1 CNZOURNMHUJTHK-RCZVLFRGSA-N 382354 US10273259, Example 67::US10711020, Example 67 Nuclear receptor ROR-gamma Mus musculus 24.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382354&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678970 404851726 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764969 C[C@@]1(CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-26(25(41)42)12-10-17(11-13-26)24(40)39-15-14-27(45(43,44)21-6-4-20(31)5-7-21)22-8-3-19(16-18(22)2-9-23(27)39)28(32,29(33,34)35)30(36,37)38/h3-8,16-17,23H,2,9-15H2,1H3,(H,41,42)/t17-,23-,26-,27-/m1/s1 RNUYUEWIROQCAN-ZKPUSUNFSA-N 382355 US10273259, Example 68::US10711020, Example 68 Nuclear receptor ROR-gamma Mus musculus 23.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382355&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678779 404851727 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764970 OC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO6S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-36(22(37)23(38)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,38H,1,8-14H2/t21-,24-/m1/s1 ONXFNBOZJKXCNC-ZJSXRUAMSA-N 382356 US10273259, Example 69::US10711020, Example 69 Nuclear receptor ROR-gamma Mus musculus 36.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382356&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669265 404851728 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764971 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-38(24(41)25(42)11-9-16(10-12-25)23(39)40)22(26)8-1-17-15-18(2-7-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-7,15-16,22,42H,1,8-14H2,(H,39,40)/t16-,22-,25+,26-/m1/s1 NIKFOKKZAYXJKS-PNOGGZOTSA-N 382357 US10273259, Example 70::US10711020, Example 70 Nuclear receptor ROR-gamma Mus musculus 68.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382357&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678576 404851729 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764972 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F5NO5S/c29-20-7-9-21(10-8-20)40(38,39)27-13-14-34(24(35)16-1-3-17(4-2-16)25(36)37)23(27)12-5-18-15-19(6-11-22(18)27)28(32,33)26(30)31/h6-11,15-17,23,26H,1-5,12-14H2,(H,36,37)/t16-,17-,23?,27? NPGFCSYDVJDLGO-VMGIOJFMSA-N 382358 US10273259, Example 71 Nuclear receptor ROR-gamma Mus musculus 31.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382358&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995585 404851730 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764973 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F6NO5S/c31-20-3-5-21(6-4-20)43(41,42)28-15-16-37(24(38)26-9-12-27(13-10-26,14-11-26)25(39)40)23(28)8-1-18-17-19(2-7-22(18)28)29(32,33)30(34,35)36/h2-7,17,23H,1,8-16H2,(H,39,40) WUTQPYOBYMGHLC-UHFFFAOYSA-N 382359 US10273259, Example 72::US10711020, Example 74 Nuclear receptor ROR-gamma Mus musculus 28.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382359&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123756 404851731 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764974 Cc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO6S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-38(25(41)26(42)12-10-18(11-13-26)24(39)40)23(27)9-4-19-16-20(5-8-22(19)27)28(31,29(32,33)34)30(35,36)37/h2-3,5-8,16,18,23,42H,4,9-15H2,1H3,(H,39,40)/t18-,23-,26+,27-/m1/s1 HZUVIRMBMVZZEX-GSSVGNISSA-N 382360 US10273259, Example 73::US10711020, Example 73 Nuclear receptor ROR-gamma Mus musculus 78.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382360&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678780 404851732 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764975 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F5NO5S/c31-20-3-5-21(6-4-20)42(40,41)29-15-16-36(25(37)27-9-12-28(13-10-27,14-11-27)26(38)39)23(29)8-1-18-17-19(2-7-22(18)29)30(34,35)24(32)33/h2-7,17,23-24H,1,8-16H2,(H,38,39) FOQPAUJPHCQMGZ-UHFFFAOYSA-N 382361 US10273259, Example 74 Nuclear receptor ROR-gamma Mus musculus 18.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382361&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 146047736 404851733 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764976 OC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H26F7NO6S2/c28-25(26(29,30)31,27(32,33)34)18-7-8-20-17(16-18)6-9-21-24(20,43(40,41)19-4-2-1-3-5-19)10-13-35(21)22(36)23(37)11-14-42(38,39)15-12-23/h1-5,7-8,16,21,37H,6,9-15H2/t21-,24-/m1/s1 RCFBNKKNTAABCX-ZJSXRUAMSA-N 382362 US10273259, Example 75::US10711020, Example 75 Nuclear receptor ROR-gamma Mus musculus 43.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382362&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678574 404851734 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764977 CC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H28F7NO5S2/c1-24(12-15-42(38,39)16-13-24)23(37)36-14-11-25(43(40,41)20-5-3-2-4-6-20)21-9-8-19(17-18(21)7-10-22(25)36)26(29,27(30,31)32)28(33,34)35/h2-6,8-9,17,22H,7,10-16H2,1H3/t22-,25-/m1/s1 KRPYRQCNVXRDGI-RCZVLFRGSA-N 382363 US10273259, Example 76::US10711020, Example 76 Nuclear receptor ROR-gamma Mus musculus 45.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382363&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678582 404851735 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764978 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H27F8NO5S/c30-25(12-10-17(11-13-25)23(39)40)24(41)38-15-14-26(44(42,43)20-4-2-1-3-5-20)21-8-7-19(16-18(21)6-9-22(26)38)27(31,28(32,33)34)29(35,36)37/h1-5,7-8,16-17,22H,6,9-15H2,(H,39,40)/t17-,22-,25+,26-/m1/s1 YYNXLIDUFMGKIU-FQQZQYMPSA-N 382364 US10273259, Example 77::US10711020, Example 77 Nuclear receptor ROR-gamma Mus musculus 33.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382364&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678860 404851736 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764979 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H27F8NO5S/c30-25(24(40)41)12-10-17(11-13-25)23(39)38-15-14-26(44(42,43)20-4-2-1-3-5-20)21-8-7-19(16-18(21)6-9-22(26)38)27(31,28(32,33)34)29(35,36)37/h1-5,7-8,16-17,22H,6,9-15H2,(H,40,41)/t17-,22-,25+,26-/m1/s1 VQRUKJALSUNAQR-FQQZQYMPSA-N 382365 US10273259, Example 78::US10711020, Example 78 Nuclear receptor ROR-gamma Mus musculus 42.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382365&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678986 404851737 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764980 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H28F7NO6S/c30-27(28(31,32)33,29(34,35)36)19-7-8-21-18(16-19)6-9-22-26(21,44(42,43)20-4-2-1-3-5-20)14-15-37(22)24(40)25(41)12-10-17(11-13-25)23(38)39/h1-5,7-8,16-17,22,41H,6,9-15H2,(H,38,39)/t17-,22-,25+,26-/m1/s1 WSLUKAWNPCTYDQ-FQQZQYMPSA-N 382366 US10273259, Example 79 Nuclear receptor ROR-gamma Mus musculus 33.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382366&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678855 404851738 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764981 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F6NO5S/c29-20-7-9-21(10-8-20)41(39,40)26-13-14-35(24(36)16-1-3-17(4-2-16)25(37)38)23(26)12-5-18-15-19(6-11-22(18)26)27(30,31)28(32,33)34/h6-11,15-17,23H,1-5,12-14H2,(H,37,38)/t16-,17-,23?,26? ZSEJTFSGSGDQLS-LRVXPCDCSA-N 382367 US10273259, Example 80 Nuclear receptor ROR-gamma Mus musculus 19.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382367&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123610 404851739 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764982 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H26F7NO6S/c29-26(27(30,31)32,28(33,34)35)18-10-11-20-21(14-18)42-15-22-25(20,43(40,41)19-4-2-1-3-5-19)12-13-36(22)23(37)16-6-8-17(9-7-16)24(38)39/h1-5,10-11,14,16-17,22H,6-9,12-13,15H2,(H,38,39)/t16-,17-,22?,25? INPQVNKLKDYELZ-FECXEKGZSA-N 382368 US10273259, Example 81::US10711020, Example 81 Nuclear receptor ROR-gamma Mus musculus 46.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382368&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678783 404851740 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764983 FC(F)(F)C(F)(c1ccc2c(OCC3N(CCC23S(=O)(=O)c2ccccc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H24F7NO6S2/c27-24(25(28,29)30,26(31,32)33)17-6-7-19-20(14-17)40-15-21-23(19,42(38,39)18-4-2-1-3-5-18)10-11-34(21)22(35)16-8-12-41(36,37)13-9-16/h1-7,14,16,21H,8-13,15H2 HZXMXVQPZQPLMM-UHFFFAOYSA-N 382369 US10273259, Example 82::US10711020, Example 82 Nuclear receptor ROR-gamma Mus musculus 67.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382369&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678858 404851741 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764984 C[C@@]1(CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(O)=O InChI=1S/C29H28F7NO6S/c1-25(24(39)40)11-9-17(10-12-25)23(38)37-14-13-26(44(41,42)19-5-3-2-4-6-19)20-8-7-18(15-21(20)43-16-22(26)37)27(30,28(31,32)33)29(34,35)36/h2-8,15,17,22H,9-14,16H2,1H3,(H,39,40)/t17-,22?,25-,26? UGGQWQNGBFUCAT-VWGAXAFBSA-N 382370 US10273259, Example 83::US10711020, Example 83 Nuclear receptor ROR-gamma Mus musculus 39.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382370&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678578 404851742 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764985 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H25F8NO6S/c29-24(10-8-16(9-11-24)22(38)39)23(40)37-13-12-25(44(41,42)18-4-2-1-3-5-18)19-7-6-17(14-20(19)43-15-21(25)37)26(30,27(31,32)33)28(34,35)36/h1-7,14,16,21H,8-13,15H2,(H,38,39)/t16-,21?,24+,25? VXOOZMHBUVWMTC-QNINJKENSA-N 382372 US10273259, Example 84::US10711020, Example 84 Nuclear receptor ROR-gamma Mus musculus 33.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382372&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678787 404851744 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764986 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H26F7NO6S2/c1-23(10-13-42(37,38)14-11-23)22(36)35-12-9-24(43(39,40)18-5-3-2-4-6-18)19-8-7-17(15-20(19)41-16-21(24)35)25(28,26(29,30)31)27(32,33)34/h2-8,15,21H,9-14,16H2,1H3 ZQRMMOBPNILDIZ-UHFFFAOYSA-N 382373 US10273259, Example 85::US10711020, Example 85 Nuclear receptor ROR-gamma Mus musculus 16.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382373&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678997 404851745 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764987 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H28F7NO6S/c1-25(11-9-17(10-12-25)23(38)39)24(40)37-14-13-26(44(41,42)19-5-3-2-4-6-19)20-8-7-18(15-21(20)43-16-22(26)37)27(30,28(31,32)33)29(34,35)36/h2-8,15,17,22H,9-14,16H2,1H3,(H,38,39)/t17-,22?,25-,26? IKWYTHJBHVJSDY-VWGAXAFBSA-N 382374 US10273259, Example 86::US10711020, Example 86 Nuclear receptor ROR-gamma Mus musculus 41.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382374&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678857 404851746 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764988 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H25F8NO6S/c29-24(23(39)40)10-8-16(9-11-24)22(38)37-13-12-25(44(41,42)18-4-2-1-3-5-18)19-7-6-17(14-20(19)43-15-21(25)37)26(30,27(31,32)33)28(34,35)36/h1-7,14,16,21H,8-13,15H2,(H,39,40)/t16-,21?,24+,25? AHDDXJIGAVOHPK-QNINJKENSA-N 382375 US10273259, Example 87::US10711020, Example 87 Nuclear receptor ROR-gamma Mus musculus 39.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382375&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678865 404851747 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764989 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C30H28F7NO6S/c31-28(29(32,33)34,30(35,36)37)18-6-7-20-21(16-18)44-17-22-27(20,45(42,43)19-4-2-1-3-5-19)14-15-38(22)23(39)25-8-11-26(12-9-25,13-10-25)24(40)41/h1-7,16,22H,8-15,17H2,(H,40,41) INMOJOTXZUOHSX-UHFFFAOYSA-N 382376 US10273259, Example 88::US10711020, Example 88 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382376&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678870 404851748 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764990 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H24F7NO7S2/c27-24(25(28,29)30,26(31,32)33)16-6-7-18-19(14-16)41-15-20-23(18,43(39,40)17-4-2-1-3-5-17)8-11-34(20)21(35)22(36)9-12-42(37,38)13-10-22/h1-7,14,20,36H,8-13,15H2 IQHNBPNFOBFJAZ-UHFFFAOYSA-N 382377 US10273259, Example 89::US10711020, Example 89 Nuclear receptor ROR-gamma Mus musculus 79.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382377&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678878 404851749 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764991 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H28F7NO6S2/c1-17-2-6-20(7-3-17)44(41,42)25-10-13-36(23(37)24(38)11-14-43(39,40)15-12-24)22(25)9-4-18-16-19(5-8-21(18)25)26(29,27(30,31)32)28(33,34)35/h2-3,5-8,16,22,38H,4,9-15H2,1H3 CNFDTDNDGRHKHU-UHFFFAOYSA-N 382378 US10273259, Example 90::US10711020, Example 90 Nuclear receptor ROR-gamma Mus musculus 76.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382378&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678657 404851750 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764992 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(C)CCS(=O)(=O)CC1 InChI=1S/C29H30F7NO5S2/c1-18-3-7-21(8-4-18)44(41,42)26-11-14-37(24(38)25(2)12-15-43(39,40)16-13-25)23(26)10-5-19-17-20(6-9-22(19)26)27(30,28(31,32)33)29(34,35)36/h3-4,6-9,17,23H,5,10-16H2,1-2H3 HEZBHCDVHMWMHJ-UHFFFAOYSA-N 382379 US10273259, Example 91::US10711020, Example 91 Nuclear receptor ROR-gamma Mus musculus 28.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382379&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678579 404851751 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764993 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H23F7N2O5S/c1-34-18(9-10-21(34)36)22(37)35-12-11-23(41(38,39)16-5-3-2-4-6-16)17-8-7-15(13-19(17)40-14-20(23)35)24(27,25(28,29)30)26(31,32)33/h2-8,13,18,20H,9-12,14H2,1H3/t18-,20?,23?/m0/s1 XFAGESYDLJMEQC-QRGRWYIGSA-N 382380 US10273259, Example 92::US10273259, Example 94::US10711020, Example 94 Nuclear receptor ROR-gamma Mus musculus 62.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382380&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678991 404851752 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764994 CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H25F7N2O4S/c1-35-20(10-12-22(35)37)23(38)36-14-13-24(41(39,40)18-5-3-2-4-6-18)19-9-8-17(15-16(19)7-11-21(24)36)25(28,26(29,30)31)27(32,33)34/h2-6,8-9,15,20-21H,7,10-14H2,1H3/t20-,21+,24+/m0/s1 PONKZASPLBAOKT-YZUZCNPQSA-N 382381 US10273259, Example 93::US10273259, Example 95::US10711020, Example 95 Nuclear receptor ROR-gamma Mus musculus 71.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382381&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678879 404851753 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764995 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H23F7N2O5S/c1-34-18(9-10-21(34)36)22(37)35-12-11-23(41(38,39)16-5-3-2-4-6-16)17-8-7-15(13-19(17)40-14-20(23)35)24(27,25(28,29)30)26(31,32)33/h2-8,13,18,20H,9-12,14H2,1H3/t18-,20?,23?/m0/s1 XFAGESYDLJMEQC-QRGRWYIGSA-N 382380 US10273259, Example 92::US10273259, Example 94::US10711020, Example 94 Nuclear receptor ROR-gamma Mus musculus 20.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382380&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678991 404851752 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764996 CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H25F7N2O4S/c1-35-20(10-12-22(35)37)23(38)36-14-13-24(41(39,40)18-5-3-2-4-6-18)19-9-8-17(15-16(19)7-11-21(24)36)25(28,26(29,30)31)27(32,33)34/h2-6,8-9,15,20-21H,7,10-14H2,1H3/t20-,21+,24+/m0/s1 PONKZASPLBAOKT-YZUZCNPQSA-N 382381 US10273259, Example 93::US10273259, Example 95::US10711020, Example 95 Nuclear receptor ROR-gamma Mus musculus 50.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382381&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678879 404851753 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764997 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27ClF7NO5S2/c1-16-2-5-20(15-22(16)29)44(41,42)25-10-11-37(24(38)17-8-12-43(39,40)13-9-17)23(25)7-3-18-14-19(4-6-21(18)25)26(30,27(31,32)33)28(34,35)36/h2,4-6,14-15,17,23H,3,7-13H2,1H3 TYROYDROEXPYSI-UHFFFAOYSA-N 382384 US10273259, Example 96::US10711020, Example 96 Nuclear receptor ROR-gamma Mus musculus 118 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382384&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678583 404851754 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764998 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO5S/c1-16-2-9-21(15-23(16)31)45(43,44)27-12-13-39(25(40)17-3-5-18(6-4-17)26(41)42)24(27)11-7-19-14-20(8-10-22(19)27)28(32,29(33,34)35)30(36,37)38/h2,8-10,14-15,17-18,24H,3-7,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? DRMBQFRPYKUROH-VRSFHCCXSA-N 382385 US10273259, Example 97::US10711020, Example 97 Nuclear receptor ROR-gamma Mus musculus 146 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382385&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678587 404851755 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 764999 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28ClF8NO5S/c1-16-2-5-20(15-22(16)31)46(44,45)27-12-13-40(25(43)26(32)10-8-17(9-11-26)24(41)42)23(27)7-3-18-14-19(4-6-21(18)27)28(33,29(34,35)36)30(37,38)39/h2,4-6,14-15,17,23H,3,7-13H2,1H3,(H,41,42)/t17-,23?,26+,27? KEAQWRPTKBMNPV-MTOUGUCQSA-N 382386 US10273259, Example 98::US10711020, Example 98 Nuclear receptor ROR-gamma Mus musculus 133 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382386&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679006 404851756 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765000 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C31H31ClF7NO5S/c1-17-3-6-21(16-23(17)32)46(44,45)28-13-14-40(25(41)18-9-11-27(2,12-10-18)26(42)43)24(28)8-4-19-15-20(5-7-22(19)28)29(33,30(34,35)36)31(37,38)39/h3,5-7,15-16,18,24H,4,8-14H2,1-2H3,(H,42,43)/t18-,24?,27-,28? OLZARMZJSUUYAH-GLMFJJLTSA-N 382387 US10273259, Example 99::US10711020, Example 99 Nuclear receptor ROR-gamma Mus musculus 84.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382387&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678995 404851757 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765001 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H27ClF7NO6S2/c1-16-2-5-19(15-21(16)29)45(42,43)25-8-11-37(23(38)24(39)9-12-44(40,41)13-10-24)22(25)7-3-17-14-18(4-6-20(17)25)26(30,27(31,32)33)28(34,35)36/h2,4-6,14-15,22,39H,3,7-13H2,1H3 NHMKCWFDDYHIQL-UHFFFAOYSA-N 382388 US10273259, Example 100::US10711020, Example 100 Nuclear receptor ROR-gamma Mus musculus 175 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382388&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678873 404851758 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765002 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C30H28ClF8NO5S/c1-16-2-5-20(15-22(16)31)46(44,45)27-12-13-40(24(41)17-8-10-26(32,11-9-17)25(42)43)23(27)7-3-18-14-19(4-6-21(18)27)28(33,29(34,35)36)30(37,38)39/h2,4-6,14-15,17,23H,3,7-13H2,1H3,(H,42,43)/t17-,23?,26+,27? WBFMVNPIZFZVHK-MTOUGUCQSA-N 382389 US10273259, Example 101::US10711020, Example 101 Nuclear receptor ROR-gamma Mus musculus 163 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382389&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678886 404851759 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765003 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H31ClF7NO5S/c1-18-2-5-21(17-23(18)33)47(45,46)29-14-15-41(25(42)27-8-11-28(12-9-27,13-10-27)26(43)44)24(29)7-3-19-16-20(4-6-22(19)29)30(34,31(35,36)37)32(38,39)40/h2,4-6,16-17,24H,3,7-15H2,1H3,(H,43,44) NXBJARFKJWFEIZ-UHFFFAOYSA-N 382390 US10273259, Example 102::US10711020, Example 102 Nuclear receptor ROR-gamma Mus musculus 124 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382390&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679008 404851760 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765004 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO6S/c1-16-2-5-20(15-22(16)31)46(44,45)27-12-13-39(25(42)26(43)10-8-17(9-11-26)24(40)41)23(27)7-3-18-14-19(4-6-21(18)27)28(32,29(33,34)35)30(36,37)38/h2,4-6,14-15,17,23,43H,3,7-13H2,1H3,(H,40,41)/t17-,23?,26+,27? RPNPBNYDSJZIET-MTOUGUCQSA-N 382391 US10273259, Example 103::US10711020, Example 103 Nuclear receptor ROR-gamma Mus musculus 108 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382391&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678998 404851761 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765005 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C30H27F10NO5S/c31-27(29(35,36)37,30(38,39)40)20-8-11-22-18(15-20)5-12-23-26(22,47(45,46)21-9-6-19(7-10-21)28(32,33)34)13-14-41(23)24(42)16-1-3-17(4-2-16)25(43)44/h6-11,15-17,23H,1-5,12-14H2,(H,43,44)/t16-,17-,23?,26? JWCSFLGFDNXEQO-LRVXPCDCSA-N 382392 US10273259, Example 104::US10711020, Example 104 Nuclear receptor ROR-gamma Mus musculus 263 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382392&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123479 404851762 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765006 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C29H27F10NO5S2/c1-24(11-14-46(42,43)15-12-24)23(41)40-13-10-25(47(44,45)20-6-3-18(4-7-20)27(31,32)33)21-8-5-19(16-17(21)2-9-22(25)40)26(30,28(34,35)36)29(37,38)39/h3-8,16,22H,2,9-15H2,1H3 WHOHSHCFKPBOFB-UHFFFAOYSA-N 382393 US10273259, Example 105::US10711020, Example 105 Nuclear receptor ROR-gamma Mus musculus 230 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382393&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123475 404851763 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765007 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1 InChI=1S/C30H30F7NO5S/c31-28(29(32,33)34,30(35,36)37)22-11-12-23-21(16-22)10-13-24-27(23,44(42,43)17-18-4-2-1-3-5-18)14-15-38(24)25(39)19-6-8-20(9-7-19)26(40)41/h1-5,11-12,16,19-20,24H,6-10,13-15,17H2,(H,40,41)/t19-,20-,24?,27? RTRLDILTCFOVAH-QJAGXIKFSA-N 382394 US10273259, Example 106::US10711020, Example 106 Nuclear receptor ROR-gamma Mus musculus 55.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382394&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678792 404851764 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765008 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)Cc2ccccc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C28H28F7NO5S2/c29-26(27(30,31)32,28(33,34)35)21-7-8-22-20(16-21)6-9-23-25(22,43(40,41)17-18-4-2-1-3-5-18)12-13-36(23)24(37)19-10-14-42(38,39)15-11-19/h1-5,7-8,16,19,23H,6,9-15,17H2 RKKBHGMQMCNGAE-UHFFFAOYSA-N 382395 US10273259, Example 107::US10711020, Example 107 Nuclear receptor ROR-gamma Mus musculus 51.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382395&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679000 404851765 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765009 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1 InChI=1S/C32H32F7NO5S/c33-30(31(34,35)36,32(37,38)39)22-7-8-23-21(18-22)6-9-24-29(23,46(44,45)19-20-4-2-1-3-5-20)16-17-40(24)25(41)27-10-13-28(14-11-27,15-12-27)26(42)43/h1-5,7-8,18,24H,6,9-17,19H2,(H,42,43) GSXDSWBPTORMQS-UHFFFAOYSA-N 382396 US10273259, Example 108::US10711020, Example 108 Nuclear receptor ROR-gamma Mus musculus 50.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382396&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678588 404851766 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765010 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C32H29F10NO5S/c33-29(31(37,38)39,32(40,41)42)20-4-7-22-18(17-20)1-8-23-28(22,49(47,48)21-5-2-19(3-6-21)30(34,35)36)15-16-43(23)24(44)26-9-12-27(13-10-26,14-11-26)25(45)46/h2-7,17,23H,1,8-16H2,(H,45,46) SSFHOCAPGURBBW-UHFFFAOYSA-N 382397 US10273259, Example 109::US10711020, Example 109 Nuclear receptor ROR-gamma Mus musculus 74.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382397&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123824 404851767 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765011 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C28H25F10NO6S2/c29-25(27(33,34)35,28(36,37)38)18-4-7-20-16(15-18)1-8-21-24(20,47(44,45)19-5-2-17(3-6-19)26(30,31)32)9-12-39(21)22(40)23(41)10-13-46(42,43)14-11-23/h2-7,15,21,41H,1,8-14H2 IRRSKOHWHZTXSS-UHFFFAOYSA-N 382398 US10273259, Example 110::US10711020, Example 110 Nuclear receptor ROR-gamma Mus musculus 93.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382398&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123765 404851768 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765012 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C32H33F8NO5S/c1-18(2)19-3-7-23(8-4-19)47(45,46)29-15-16-41(26(42)20-11-13-28(33,14-12-20)27(43)44)25(29)10-5-21-17-22(6-9-24(21)29)30(34,31(35,36)37)32(38,39)40/h3-4,6-9,17-18,20,25H,5,10-16H2,1-2H3,(H,43,44)/t20-,25?,28+,29? IUMIVCLDNMESOE-GZAOQYKUSA-N 382399 US10273259, Example 111::US10711020, Example 111 Nuclear receptor ROR-gamma Mus musculus 58.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382399&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123772 404851769 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765013 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C32H33F8NO5S/c1-18(2)19-3-7-23(8-4-19)47(45,46)29-15-16-41(27(44)28(33)13-11-20(12-14-28)26(42)43)25(29)10-5-21-17-22(6-9-24(21)29)30(34,31(35,36)37)32(38,39)40/h3-4,6-9,17-18,20,25H,5,10-16H2,1-2H3,(H,42,43)/t20-,25?,28+,29? VXFIPBDLADOJIH-GZAOQYKUSA-N 382400 US10273259, Example 112::US10711020, Example 112 Nuclear receptor ROR-gamma Mus musculus 90.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382400&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123825 404851770 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765014 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H34F7NO5S/c1-18(2)19-7-11-24(12-8-19)46(44,45)29-15-16-40(27(41)20-3-5-21(6-4-20)28(42)43)26(29)14-9-22-17-23(10-13-25(22)29)30(33,31(34,35)36)32(37,38)39/h7-8,10-13,17-18,20-21,26H,3-6,9,14-16H2,1-2H3,(H,42,43)/t20-,21-,26?,29? QFVFNFDGHMYBIJ-ZAOANWOTSA-N 382401 US10273259, Example 113::US10711020, Example 113 Nuclear receptor ROR-gamma Mus musculus 118 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382401&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123480 404851771 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765015 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C34H36F7NO5S/c1-20(2)21-3-7-24(8-4-21)48(46,47)31-17-18-42(27(43)29-11-14-30(15-12-29,16-13-29)28(44)45)26(31)10-5-22-19-23(6-9-25(22)31)32(35,33(36,37)38)34(39,40)41/h3-4,6-9,19-20,26H,5,10-18H2,1-2H3,(H,44,45) MECCTNDTONQWLK-UHFFFAOYSA-N 382402 US10273259, Example 114::US10711020, Example 114 Nuclear receptor ROR-gamma Mus musculus 73.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382402&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123722 404851772 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765016 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(I)ccc21)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C27H29ClINO5S/c1-16-14-21(8-10-23(16)28)36(34,35)27-12-13-30(25(31)17-2-4-18(5-3-17)26(32)33)24(27)11-6-19-15-20(29)7-9-22(19)27/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,32,33)/t17-,18-,24?,27? GOOKSKCEQCJEFL-VRSFHCCXSA-N 382403 US10273259, Example 115::US10711020, Example 115 Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382403&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678900 404851773 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765017 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccccn2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H25F7N2O5S2/c27-24(25(28,29)30,26(31,32)33)18-5-6-19-17(15-18)4-7-20-23(19,42(39,40)21-3-1-2-11-34-21)10-12-35(20)22(36)16-8-13-41(37,38)14-9-16/h1-3,5-6,11,15-16,20H,4,7-10,12-14H2 GMYAHKGUKTUYTI-UHFFFAOYSA-N 382404 US10273259, Example 116::US10273259, Example 181::US10711020, Example 116 Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382404&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678791 404851774 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765018 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C28H27F7N2O5S/c29-26(27(30,31)32,28(33,34)35)19-9-10-20-18(15-19)8-11-21-25(20,43(41,42)22-3-1-2-13-36-22)12-14-37(21)23(38)16-4-6-17(7-5-16)24(39)40/h1-3,9-10,13,15-17,21H,4-8,11-12,14H2,(H,39,40)/t16-,17-,21?,25? CPBKYNQJGQJOLW-QWDHGTDNSA-N 382405 US10273259, Example 117::US10711020, Example 117 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382405&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678590 404851775 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765019 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C30H29F7N2O5S/c31-28(29(32,33)34,30(35,36)37)19-5-6-20-18(17-19)4-7-21-27(20,45(43,44)22-3-1-2-15-38-22)14-16-39(21)23(40)25-8-11-26(12-9-25,13-10-25)24(41)42/h1-3,5-6,15,17,21H,4,7-14,16H2,(H,41,42) QDEUATGCIBILHF-UHFFFAOYSA-N 382406 US10273259, Example 118::US10711020, Example 118 Nuclear receptor ROR-gamma Mus musculus 71.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382406&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679014 404851776 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765020 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C31H31F8NO5S/c1-2-18-3-7-22(8-4-18)46(44,45)28-15-16-40(26(43)27(32)13-11-19(12-14-27)25(41)42)24(28)10-5-20-17-21(6-9-23(20)28)29(33,30(34,35)36)31(37,38)39/h3-4,6-9,17,19,24H,2,5,10-16H2,1H3,(H,41,42)/t19-,24?,27+,28? LLIXOENZWMJLPD-SDUUHUFGSA-N 382407 US10273259, Example 119::US10711020, Example 119 Nuclear receptor ROR-gamma Mus musculus 58.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382407&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679005 404851777 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765021 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C31H31F8NO5S/c1-2-18-3-7-22(8-4-18)46(44,45)28-15-16-40(25(41)19-11-13-27(32,14-12-19)26(42)43)24(28)10-5-20-17-21(6-9-23(20)28)29(33,30(34,35)36)31(37,38)39/h3-4,6-9,17,19,24H,2,5,10-16H2,1H3,(H,42,43)/t19-,24?,27+,28? GJSBXBJHUCKEAU-SDUUHUFGSA-N 382408 US10273259, Example 120::US10711020, Example 120 Nuclear receptor ROR-gamma Mus musculus 83.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382408&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678664 404851778 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765022 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C29H30F7NO6S2/c1-2-18-3-7-21(8-4-18)45(42,43)26-11-14-37(24(38)25(39)12-15-44(40,41)16-13-25)23(26)10-5-19-17-20(6-9-22(19)26)27(30,28(31,32)33)29(34,35)36/h3-4,6-9,17,23,39H,2,5,10-16H2,1H3 OEUGOJRLLLPCDD-UHFFFAOYSA-N 382409 US10273259, Example 121::US10711020, Example 121 Nuclear receptor ROR-gamma Mus musculus 51.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382409&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678593 404851779 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765023 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO5S/c1-2-18-3-11-23(12-4-18)45(43,44)28-15-16-39(26(40)19-5-7-20(8-6-19)27(41)42)25(28)14-9-21-17-22(10-13-24(21)28)29(32,30(33,34)35)31(36,37)38/h3-4,10-13,17,19-20,25H,2,5-9,14-16H2,1H3,(H,41,42)/t19-,20-,25?,28? GSIIMBVMJFEAKF-IUKKCNNLSA-N 382410 US10273259, Example 122::US10711020, Example 122 Nuclear receptor ROR-gamma Mus musculus 127 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382410&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678898 404851780 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765024 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C33H34F7NO5S/c1-2-20-3-7-23(8-4-20)47(45,46)30-17-18-41(26(42)28-11-14-29(15-12-28,16-13-28)27(43)44)25(30)10-5-21-19-22(6-9-24(21)30)31(34,32(35,36)37)33(38,39)40/h3-4,6-9,19,25H,2,5,10-18H2,1H3,(H,43,44) LNZNBDGBDUSQDR-UHFFFAOYSA-N 382411 US10273259, Example 123::US10711020, Example 123 Nuclear receptor ROR-gamma Mus musculus 43.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382411&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678666 404851781 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765025 CC(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C30H32F7NO6S2/c1-18(2)19-3-7-22(8-4-19)46(43,44)27-11-14-38(25(39)26(40)12-15-45(41,42)16-13-26)24(27)10-5-20-17-21(6-9-23(20)27)28(31,29(32,33)34)30(35,36)37/h3-4,6-9,17-18,24,40H,5,10-16H2,1-2H3 JPWRMQFWCRVQBG-UHFFFAOYSA-N 382412 US10273259, Example 124::US10711020, Example 124 Nuclear receptor ROR-gamma Mus musculus 188 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382412&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679010 404851782 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765026 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO6S/c1-2-18-3-7-22(8-4-18)46(44,45)28-15-16-39(26(42)27(43)13-11-19(12-14-27)25(40)41)24(28)10-5-20-17-21(6-9-23(20)28)29(32,30(33,34)35)31(36,37)38/h3-4,6-9,17,19,24,43H,2,5,10-16H2,1H3,(H,40,41)/t19-,24?,27+,28? MYYLAIRAHITLDJ-SDUUHUFGSA-N 382413 US10273259, Example 125::US10711020, Example 125 Nuclear receptor ROR-gamma Mus musculus 52.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382413&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678594 404851783 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765027 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C28H26F8N2O5S/c29-24(23(40)41)10-8-16(9-11-24)22(39)38-14-12-25(44(42,43)21-3-1-2-13-37-21)19-6-5-18(15-17(19)4-7-20(25)38)26(30,27(31,32)33)28(34,35)36/h1-3,5-6,13,15-16,20H,4,7-12,14H2,(H,40,41)/t16-,20?,24+,25? FEXHUAMBJOPDLF-DWOZHRLGSA-N 382414 US10273259, Example 126::US10711020, Example 126 Nuclear receptor ROR-gamma Mus musculus 109 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382414&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678794 404851784 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765028 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C28H27F7N2O6S/c29-26(27(30,31)32,28(33,34)35)18-5-6-19-17(15-18)4-7-20-25(19,44(42,43)21-3-1-2-13-36-21)12-14-37(20)23(40)24(41)10-8-16(9-11-24)22(38)39/h1-3,5-6,13,15-16,20,41H,4,7-12,14H2,(H,38,39)/t16-,20?,24+,25? PIIPQVLYLRRHBF-DWOZHRLGSA-N 382415 US10273259, Example 127::US10711020, Example 127 Nuclear receptor ROR-gamma Mus musculus 44.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382415&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678797 404851785 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765029 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C28H26F8N2O5S/c29-24(10-8-16(9-11-24)22(39)40)23(41)38-14-12-25(44(42,43)21-3-1-2-13-37-21)19-6-5-18(15-17(19)4-7-20(25)38)26(30,27(31,32)33)28(34,35)36/h1-3,5-6,13,15-16,20H,4,7-12,14H2,(H,39,40)/t16-,20?,24+,25? RWHOTDWUUJYFAK-DWOZHRLGSA-N 382416 US10273259, Example 128::US10711020, Example 128 Nuclear receptor ROR-gamma Mus musculus 82.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382416&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678667 404851786 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765030 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO6S2/c1-23(9-12-43(38,39)13-10-23)22(37)36-11-8-24(44(40,41)18-5-3-17(28)4-6-18)19-7-2-16(14-20(19)42-15-21(24)36)25(29,26(30,31)32)27(33,34)35/h2-7,14,21H,8-13,15H2,1H3 LUDHLKCTEDXNHC-UHFFFAOYSA-N 382417 US10273259, Example 129::US10711020, Example 129 Nuclear receptor ROR-gamma Mus musculus 42.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382417&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678799 404851787 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765031 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F9NO6S/c29-17-2-4-18(5-3-17)45(42,43)25-11-12-38(22(39)15-7-9-24(30,10-8-15)23(40)41)21(25)14-44-20-13-16(1-6-19(20)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21H,7-12,14H2,(H,40,41)/t15-,21?,24+,25? PSWRMIOHPUAQEO-DNNXONSASA-N 382418 US10273259, Example 130::US10711020, Example 130 Nuclear receptor ROR-gamma Mus musculus 94.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382418&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678671 404851788 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765032 C[C@@]1(CC[C@@H](CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C29H27F8NO6S/c1-25(24(40)41)10-8-16(9-11-25)23(39)38-13-12-26(45(42,43)19-5-3-18(30)4-6-19)20-7-2-17(14-21(20)44-15-22(26)38)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22H,8-13,15H2,1H3,(H,40,41)/t16-,22?,25-,26? ALHXVPACIBAJJZ-FVSSTLBOSA-N 382419 US10273259, Example 131::US10711020, Example 131 Nuclear receptor ROR-gamma Mus musculus 79.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382419&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678596 404851789 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765033 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F9NO6S/c29-17-2-4-18(5-3-17)45(42,43)25-11-12-38(23(41)24(30)9-7-15(8-10-24)22(39)40)21(25)14-44-20-13-16(1-6-19(20)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21H,7-12,14H2,(H,39,40)/t15-,21?,24+,25? HPKDLYXZFDREEU-DNNXONSASA-N 382420 US10273259, Example 132::US10711020, Example 132 Nuclear receptor ROR-gamma Mus musculus 97.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382420&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678669 404851790 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765034 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F8NO7S2/c27-16-2-4-17(5-3-16)44(40,41)23-7-10-35(21(36)22(37)8-11-43(38,39)12-9-22)20(23)14-42-19-13-15(1-6-18(19)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,20,37H,7-12,14H2 KIQQPHOZVGKIIP-UHFFFAOYSA-N 382421 US10273259, Example 133::US10711020, Example 133 Nuclear receptor ROR-gamma Mus musculus 76.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382421&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678672 404851791 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765035 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccncc1 InChI=1S/C30H29F7N2O5S/c31-28(29(32,33)34,30(35,36)37)19-2-3-21-18(17-19)1-4-22-27(21,45(43,44)20-5-14-38-15-6-20)13-16-39(22)23(40)25-7-10-26(11-8-25,12-9-25)24(41)42/h2-3,5-6,14-15,17,22H,1,4,7-13,16H2,(H,41,42) KKBQMUJYOPVKSP-UHFFFAOYSA-N 382422 US10273259, Example 134::US10711020, Example 134 Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382422&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678901 404851792 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765036 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccncc1 InChI=1S/C28H27F7N2O5S/c29-26(27(30,31)32,28(33,34)35)19-6-7-21-18(15-19)5-8-22-25(21,43(41,42)20-9-12-36-13-10-20)11-14-37(22)23(38)16-1-3-17(4-2-16)24(39)40/h6-7,9-10,12-13,15-17,22H,1-5,8,11,14H2,(H,39,40)/t16-,17-,22?,25? ZNIXQMTYBBPOIP-FECXEKGZSA-N 382423 US10273259, Example 135::US10711020, Example 135 Nuclear receptor ROR-gamma Mus musculus 110 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382423&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678801 404851793 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765037 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO7S/c29-17-2-4-18(5-3-17)45(42,43)25-11-12-37(23(40)24(41)9-7-15(8-10-24)22(38)39)21(25)14-44-20-13-16(1-6-19(20)25)26(30,27(31,32)33)28(34,35)36/h1-6,13,15,21,41H,7-12,14H2,(H,38,39)/t15-,21?,24+,25? VVRAIPOLXFJASA-DNNXONSASA-N 382424 US10273259, Example 136::US10711020, Example 136 Nuclear receptor ROR-gamma Mus musculus 44.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382424&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678803 404851794 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765038 CC(C)(O)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H34F7NO6S/c1-28(2,44)21-8-11-23(12-9-21)47(45,46)29-15-16-40(26(41)18-3-5-19(6-4-18)27(42)43)25(29)14-7-20-17-22(10-13-24(20)29)30(33,31(34,35)36)32(37,38)39/h8-13,17-19,25,44H,3-7,14-16H2,1-2H3,(H,42,43)/t18-,19-,25?,29? CWTGBYJIEXPUAR-XCZPLDPBSA-N 382425 US10273259, Example 137::US10711020, Example 137 Nuclear receptor ROR-gamma Mus musculus 671 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382425&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678674 404851795 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765039 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c1-25(10-8-16(9-11-25)23(39)40)24(41)38-13-12-26(45(42,43)19-5-3-18(30)4-6-19)20-7-2-17(14-21(20)44-15-22(26)38)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22H,8-13,15H2,1H3,(H,39,40)/t16-,22?,25-,26? CHHAKPIZQFGHMC-FVSSTLBOSA-N 382426 US10273259, Example 138::US10711020, Example 138 Nuclear receptor ROR-gamma Mus musculus 65.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382426&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679012 404851796 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765040 CC(C)(O)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C34H36F7NO6S/c1-28(2,46)21-4-7-23(8-5-21)49(47,48)31-17-18-42(26(43)29-11-14-30(15-12-29,16-13-29)27(44)45)25(31)10-3-20-19-22(6-9-24(20)31)32(35,33(36,37)38)34(39,40)41/h4-9,19,25,46H,3,10-18H2,1-2H3,(H,44,45) MWDJDMGQUPUSTR-UHFFFAOYSA-N 382427 US10273259, Example 139::US10711020, Example 139 Nuclear receptor ROR-gamma Mus musculus 347 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382427&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678680 404851797 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765041 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C1CC1 InChI=1S/C32H32F7NO5S/c33-30(31(34,35)36,32(37,38)39)23-10-13-25-22(17-23)9-14-26-29(25,46(44,45)24-11-7-19(8-12-24)18-1-2-18)15-16-40(26)27(41)20-3-5-21(6-4-20)28(42)43/h7-8,10-13,17-18,20-21,26H,1-6,9,14-16H2,(H,42,43)/t20-,21-,26?,29? ZQAYVANPYIPETO-ZAOANWOTSA-N 382429 US10273259, Example 140::US10711020, Example 140 Nuclear receptor ROR-gamma Mus musculus 61.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382429&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678805 404851799 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765042 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F7NO5S/c1-19-2-6-22(7-3-19)46(44,45)29-16-17-40(25(41)27-10-13-28(14-11-27,15-12-27)26(42)43)24(29)9-4-20-18-21(5-8-23(20)29)30(33,31(34,35)36)32(37,38)39/h2-3,5-8,18,24H,4,9-17H2,1H3,(H,42,43) SNKGBBUIANWTAE-UHFFFAOYSA-N 382233 US10273259, Example 141::US10273259, Example 20::US10711020, Example 141 Nuclear receptor ROR-gamma Mus musculus 96.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382233&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678830 404851606 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765043 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO6S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-38(25(41)26(42)12-10-18(11-13-26)24(39)40)23(27)9-4-19-16-20(5-8-22(19)27)28(31,29(32,33)34)30(35,36)37/h2-3,5-8,16,18,23,42H,4,9-15H2,1H3,(H,39,40)/t18-,23?,26+,27? HZUVIRMBMVZZEX-MJALUPOVSA-N 382431 US10273259, Example 142::US10711020, Example 142 Nuclear receptor ROR-gamma Mus musculus 50.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382431&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145183933 404851800 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765044 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C1CC1 InChI=1S/C34H34F7NO5S/c35-32(33(36,37)38,34(39,40)41)23-6-9-25-22(19-23)5-10-26-31(25,48(46,47)24-7-3-21(4-8-24)20-1-2-20)17-18-42(26)27(43)29-11-14-30(15-12-29,16-13-29)28(44)45/h3-4,6-9,19-20,26H,1-2,5,10-18H2,(H,44,45) QFLXVLKKEGFFIU-UHFFFAOYSA-N 382432 US10273259, Example 143::US10711020, Example 143 Nuclear receptor ROR-gamma Mus musculus 129 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382432&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679023 404851801 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765045 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO5S/c1-17-2-10-22(11-3-17)44(42,43)27-14-15-38(25(39)18-4-6-19(7-5-18)26(40)41)24(27)13-8-20-16-21(9-12-23(20)27)28(31,29(32,33)34)30(35,36)37/h2-3,9-12,16,18-19,24H,4-8,13-15H2,1H3,(H,40,41)/t18-,19-,24?,27? JDFDTUYICUVLET-QXIWJBPRSA-N 382433 US10273259, Example 144 Nuclear receptor ROR-gamma Mus musculus 66.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382433&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678564 404851802 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765046 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-39(25(42)26(31)12-10-18(11-13-26)24(40)41)23(27)9-4-19-16-20(5-8-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-3,5-8,16,18,23H,4,9-15H2,1H3,(H,40,41)/t18-,23?,26+,27? RWJCYGUITJAVMC-MJALUPOVSA-N 382434 US10273259, Example 145 Nuclear receptor ROR-gamma Mus musculus 74.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382434&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678757 404851803 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765047 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](F)(CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-2-6-21(7-3-17)45(43,44)27-14-15-39(24(40)18-10-12-26(31,13-11-18)25(41)42)23(27)9-4-19-16-20(5-8-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-3,5-8,16,18,23H,4,9-15H2,1H3,(H,41,42)/t18-,23?,26+,27? WPGVXUGXFMJDHZ-MJALUPOVSA-N 382435 US10273259, Example 146 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382435&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678955 404851804 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765048 COc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F7NO6S/c1-46-21-4-6-22(7-5-21)47(44,45)29-16-17-40(25(41)27-10-13-28(14-11-27,15-12-27)26(42)43)24(29)9-2-19-18-20(3-8-23(19)29)30(33,31(34,35)36)32(37,38)39/h3-8,18,24H,2,9-17H2,1H3,(H,42,43) WVDKLXHBJUUHGG-UHFFFAOYSA-N 382436 US10273259, Example 147::US10711020, Example 147 Nuclear receptor ROR-gamma Mus musculus 250 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382436&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678600 404851805 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765049 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C33H34F7NO7S/c1-2-47-21-5-7-22(8-6-21)49(45,46)30-10-3-17-41(26(42)28-11-14-29(15-12-28,16-13-28)27(43)44)25(30)19-48-24-18-20(4-9-23(24)30)31(34,32(35,36)37)33(38,39)40/h4-9,18,25H,2-3,10-17,19H2,1H3,(H,43,44) WBLZUSMDKVYAAZ-UHFFFAOYSA-N 382437 US10273259, Example 148::US10711020, Example 148 Nuclear receptor ROR-gamma Mus musculus 442 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382437&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678908 404851806 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765050 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO7S/c1-2-45-21-9-11-22(12-10-21)47(43,44)28-14-3-15-39(26(40)18-4-6-19(7-5-18)27(41)42)25(28)17-46-24-16-20(8-13-23(24)28)29(32,30(33,34)35)31(36,37)38/h8-13,16,18-19,25H,2-7,14-15,17H2,1H3,(H,41,42)/t18-,19-,25?,28? UIBKSJWIRDQSAZ-XUNNZJKZSA-N 382438 US10273259, Example 149::US10711020, Example 149 Nuclear receptor ROR-gamma Mus musculus 265 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382438&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678684 404851807 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765051 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1 InChI=1S/C31H30F7NO5S/c32-29(30(33,34)35,31(36,37)38)22-7-8-23-19(12-22)6-9-24-28(23,45(43,44)17-18-4-2-1-3-5-18)10-11-39(24)25(40)20-13-27(14-20)15-21(16-27)26(41)42/h1-5,7-8,12,20-21,24H,6,9-11,13-17H2,(H,41,42) URMVEXBURMYAMS-UHFFFAOYSA-N 382439 US10273259, Example 150 Nuclear receptor ROR-gamma Mus musculus 11.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382439&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679019 404851808 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765052 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-19-7-9-20(10-8-19)45(42,43)26-12-1-13-38(24(39)16-2-4-17(5-3-16)25(40)41)23(26)15-44-22-14-18(6-11-21(22)26)27(31,28(32,33)34)29(35,36)37/h6-11,14,16-17,23H,1-5,12-13,15H2,(H,40,41)/t16-,17-,23?,26? GWCRKJLRLXBACM-LRVXPCDCSA-N 382440 US10273259, Example 151::US10711020, Example 151 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382440&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678809 404851809 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765053 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C32H34F7NO7S/c1-3-46-21-6-8-22(9-7-21)48(44,45)29-13-4-16-40(26(41)19-11-14-28(2,15-12-19)27(42)43)25(29)18-47-24-17-20(5-10-23(24)29)30(33,31(34,35)36)32(37,38)39/h5-10,17,19,25H,3-4,11-16,18H2,1-2H3,(H,42,43)/t19-,25?,28-,29? XOBNEYKSLOEJHF-NAOKKOESSA-N 382441 US10273259, Example 152::US10711020, Example 152 Nuclear receptor ROR-gamma Mus musculus 1631 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382441&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678687 404851810 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765054 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H29F8NO6S/c32-19-3-5-20(6-4-19)47(44,45)28-8-1-15-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)23(28)17-46-22-16-18(2-7-21(22)28)29(33,30(34,35)36)31(37,38)39/h2-7,16,23H,1,8-15,17H2,(H,42,43) MEAXOPGVTHXMOP-UHFFFAOYSA-N 382442 US10273259, Example 153::US10711020, Example 153 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382442&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678604 404851811 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765055 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H19F8NO6S/c29-18-6-8-19(9-7-18)44(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-43-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h1-10,13,22H,11-12,14H2,(H,39,40) ILAQGJPMXAMLFT-UHFFFAOYSA-N 382445 US10273259, Example 154::US10711020, Example 154 Nuclear receptor ROR-gamma Mus musculus 58.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382445&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678808 404851814 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765056 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO6S/c30-18-2-4-19(5-3-18)45(42,43)26-7-8-38(23(39)15-10-25(11-15)12-16(13-25)24(40)41)22(26)14-44-21-9-17(1-6-20(21)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,15-16,22H,7-8,10-14H2,(H,40,41) CCTNQUKJYIYGEN-UHFFFAOYSA-N 382446 US10273259, Example 155::US10711020, Example 170 Nuclear receptor ROR-gamma Mus musculus 40.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382446&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678545 404851815 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765057 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H20F7NO6S/c29-26(27(30,31)32,28(33,34)35)18-10-11-20-21(14-18)42-15-22-25(20,43(40,41)19-4-2-1-3-5-19)12-13-36(22)23(37)16-6-8-17(9-7-16)24(38)39/h1-11,14,22H,12-13,15H2,(H,38,39) PUDJFIKPZYXPHL-UHFFFAOYSA-N 382447 US10273259, Example 156::US10711020, Example 156 Nuclear receptor ROR-gamma Mus musculus 193 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382447&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679020 404851816 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765058 OC(=O)c1ccc(cc1)C(=O)N1CC[C@]2([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H21F8NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,23H,5,12-14H2,(H,40,41)/t23-,26-/m0/s1 ZKAXALRFUNLGET-OZXSUGGESA-N 382448 US10273259, Example 157::US10711020, Example 157 Nuclear receptor ROR-gamma Mus musculus 3562 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382448&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678910 404851817 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765059 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@]2([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42)/t17?,18?,23-,26?,27-/m0/s1 UPWOYPBEIAJQBZ-KOQJTCBRSA-N 382449 US10273259, Example 158 Nuclear receptor ROR-gamma Mus musculus 6188 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382449&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995587 404851818 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765060 Cc1ccc(cc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H29ClF7NO5S/c1-16-2-5-21(11-23(16)32)46(44,45)28-8-9-40(25(41)18-12-27(13-18)14-19(15-27)26(42)43)24(28)7-3-17-10-20(4-6-22(17)28)29(33,30(34,35)36)31(37,38)39/h2,4-6,10-11,18-19,24H,3,7-9,12-15H2,1H3,(H,42,43) MRQOETRHXRHSPW-UHFFFAOYSA-N 382450 US10273259, Example 159 Nuclear receptor ROR-gamma Mus musculus 82.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382450&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995588 404851819 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765061 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)Cc1ccccc1 InChI=1S/C30H24F7NO5S/c31-28(29(32,33)34,30(35,36)37)22-11-12-23-21(16-22)10-13-24-27(23,44(42,43)17-18-4-2-1-3-5-18)14-15-38(24)25(39)19-6-8-20(9-7-19)26(40)41/h1-9,11-12,16,24H,10,13-15,17H2,(H,40,41) UOAMDRXYIVRQRQ-UHFFFAOYSA-N 382451 US10273259, Example 160::US10711020, Example 160 Nuclear receptor ROR-gamma Mus musculus 196 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382451&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679028 404851820 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765062 OC(=O)C1CC2(C1)CC(C2)C(=O)[N]12CCCCC1(c1ccc(cc1OC2)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F8NO6S/c31-20-4-6-21(7-5-20)46(43,44)27-9-1-2-10-39(27,24(40)17-12-26(13-17)14-18(15-26)25(41)42)16-45-23-11-19(3-8-22(23)27)28(32,29(33,34)35)30(36,37)38/h3-8,11,17-18H,1-2,9-10,12-16H2,(H,41,42) LHKBDBVDPWYTPT-UHFFFAOYSA-N 382452 US10273259, Example 161 Nuclear receptor ROR-gamma Mus musculus 49.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382452&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995589 404851821 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765063 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C32H32F7NO7S/c1-2-46-21-5-7-22(8-6-21)48(44,45)29-10-3-11-40(26(41)18-13-28(14-18)15-19(16-28)27(42)43)25(29)17-47-24-12-20(4-9-23(24)29)30(33,31(34,35)36)32(37,38)39/h4-9,12,18-19,25H,2-3,10-11,13-17H2,1H3,(H,42,43) ZOEHIFAUSJBKOJ-UHFFFAOYSA-N 382453 US10273259, Example 162 Nuclear receptor ROR-gamma Mus musculus 1130 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382453&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678607 404851822 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765064 CCOc1ccc(cc1)S(=O)(=O)C12CCCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C31H31F8NO7S/c1-2-46-20-5-7-21(8-6-20)48(44,45)28-12-3-15-40(26(43)27(32)13-10-18(11-14-27)25(41)42)24(28)17-47-23-16-19(4-9-22(23)28)29(33,30(34,35)36)31(37,38)39/h4-9,16,18,24H,2-3,10-15,17H2,1H3,(H,41,42)/t18-,24?,27+,28? YRSCQNBXKMEDOA-UBOLYAJWSA-N 382454 US10273259, Example 163::US10711020, Example 163 Nuclear receptor ROR-gamma Mus musculus 113 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382454&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678924 404851823 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765065 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F9NO6S/c30-18-3-5-19(6-4-18)46(43,44)26-10-1-13-39(24(42)25(31)11-8-16(9-12-25)23(40)41)22(26)15-45-21-14-17(2-7-20(21)26)27(32,28(33,34)35)29(36,37)38/h2-7,14,16,22H,1,8-13,15H2,(H,40,41)/t16-,22?,25+,26? MVWMLNLMDAEPAF-VXBFRIGJSA-N 382455 US10273259, Example 164::US10711020, Example 164 Nuclear receptor ROR-gamma Mus musculus 231 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382455&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678810 404851824 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765066 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H26F7NO6S/c30-27(28(31,32)33,29(34,35)36)18-6-7-20-21(10-18)43-15-22-26(20,44(41,42)19-4-2-1-3-5-19)8-9-37(22)23(38)16-11-25(12-16)13-17(14-25)24(39)40/h1-7,10,16-17,22H,8-9,11-15H2,(H,39,40) RVNGYUPTCMYSDI-UHFFFAOYSA-N 382456 US10273259, Example 165 Nuclear receptor ROR-gamma Mus musculus 31.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382456&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678930 404851825 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765067 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H30F7NO5S/c1-17-2-6-22(7-3-17)45(43,44)28-10-11-39(25(40)19-13-27(14-19)15-20(16-27)26(41)42)24(28)9-4-18-12-21(5-8-23(18)28)29(32,30(33,34)35)31(36,37)38/h2-3,5-8,12,19-20,24H,4,9-11,13-16H2,1H3,(H,41,42) BNXFWARFAXWGKQ-UHFFFAOYSA-N 382457 US10273259, Example 166::US10711020, Example 172 Nuclear receptor ROR-gamma Mus musculus 43.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382457&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678814 404851826 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765068 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C30H21F10NO5S/c31-27(29(35,36)37,30(38,39)40)20-8-11-22-18(15-20)5-12-23-26(22,47(45,46)21-9-6-19(7-10-21)28(32,33)34)13-14-41(23)24(42)16-1-3-17(4-2-16)25(43)44/h1-4,6-11,15,23H,5,12-14H2,(H,43,44) COBJQSVVZCRECX-UHFFFAOYSA-N 382458 US10273259, Example 167::US10711020, Example 167 Nuclear receptor ROR-gamma Mus musculus 656 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382458&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679033 404851827 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765069 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)C(O)=O InChI=1S/C31H26F7NO5S/c1-2-18-3-11-23(12-4-18)45(43,44)28-15-16-39(26(40)19-5-7-20(8-6-19)27(41)42)25(28)14-9-21-17-22(10-13-24(21)28)29(32,30(33,34)35)31(36,37)38/h3-8,10-13,17,25H,2,9,14-16H2,1H3,(H,41,42) QQPSJEBSULQWPI-UHFFFAOYSA-N 382459 US10273259, Example 168::US10711020, Example 168 Nuclear receptor ROR-gamma Mus musculus 184 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382459&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678929 404851828 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765070 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO6S/c30-18-2-4-19(5-3-18)45(42,43)26-7-8-38(23(39)15-10-25(11-15)12-16(13-25)24(40)41)22(26)14-44-21-9-17(1-6-20(21)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,15-16,22H,7-8,10-14H2,(H,40,41) CCTNQUKJYIYGEN-UHFFFAOYSA-N 382460 US10273259, Example 169 Nuclear receptor ROR-gamma Mus musculus 140 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382460&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678545 404851829 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765071 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO6S/c30-18-2-4-19(5-3-18)45(42,43)26-7-8-38(23(39)15-10-25(11-15)12-16(13-25)24(40)41)22(26)14-44-21-9-17(1-6-20(21)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,15-16,22H,7-8,10-14H2,(H,40,41) CCTNQUKJYIYGEN-UHFFFAOYSA-N 382461 US10273259, Example 170 Nuclear receptor ROR-gamma Mus musculus 68.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382461&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678545 404851830 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765072 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H30F7NO5S/c1-17-2-6-22(7-3-17)45(43,44)28-10-11-39(25(40)19-13-27(14-19)15-20(16-27)26(41)42)24(28)9-4-18-12-21(5-8-23(18)28)29(32,30(33,34)35)31(36,37)38/h2-3,5-8,12,19-20,24H,4,9-11,13-16H2,1H3,(H,41,42) BNXFWARFAXWGKQ-UHFFFAOYSA-N 382462 US10273259, Example 171 Nuclear receptor ROR-gamma Mus musculus 256 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382462&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678814 404851831 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765073 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H30F7NO5S/c1-17-2-6-22(7-3-17)45(43,44)28-10-11-39(25(40)19-13-27(14-19)15-20(16-27)26(41)42)24(28)9-4-18-12-21(5-8-23(18)28)29(32,30(33,34)35)31(36,37)38/h2-3,5-8,12,19-20,24H,4,9-11,13-16H2,1H3,(H,41,42) BNXFWARFAXWGKQ-UHFFFAOYSA-N 382463 US10273259, Example 172 Nuclear receptor ROR-gamma Mus musculus 185 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382463&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678814 404851832 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765074 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C31H27F10NO5S/c32-28(30(36,37)38,31(39,40)41)20-4-7-22-16(11-20)1-8-23-27(22,48(46,47)21-5-2-19(3-6-21)29(33,34)35)9-10-42(23)24(43)17-12-26(13-17)14-18(15-26)25(44)45/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,44,45) OREGCUCQACYGQO-UHFFFAOYSA-N 382464 US10273259, Example 173::US10711020, Example 174 Nuclear receptor ROR-gamma Mus musculus 147 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382464&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 138592475 404851833 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765075 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(F)(F)F InChI=1S/C31H27F10NO5S/c32-28(30(36,37)38,31(39,40)41)20-4-7-22-16(11-20)1-8-23-27(22,48(46,47)21-5-2-19(3-6-21)29(33,34)35)9-10-42(23)24(43)17-12-26(13-17)14-18(15-26)25(44)45/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,44,45) OREGCUCQACYGQO-UHFFFAOYSA-N 382465 US10273259, Example 174 Nuclear receptor ROR-gamma Mus musculus 60.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382465&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 138592475 404851834 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765076 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C29H27F7N2O5S/c30-27(28(31,32)33,29(34,35)36)19-5-6-20-16(11-19)4-7-21-26(20,44(42,43)22-3-1-2-9-37-22)8-10-38(21)23(39)17-12-25(13-17)14-18(15-25)24(40)41/h1-3,5-6,9,11,17-18,21H,4,7-8,10,12-15H2,(H,40,41) FKJUIKKANHHJKI-UHFFFAOYSA-N 382466 US10273259, Example 175::US10711020, Example 176 Nuclear receptor ROR-gamma Mus musculus 77.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382466&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 138592460 404851835 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765077 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C29H27F7N2O5S/c30-27(28(31,32)33,29(34,35)36)19-5-6-20-16(11-19)4-7-21-26(20,44(42,43)22-3-1-2-9-37-22)8-10-38(21)23(39)17-12-25(13-17)14-18(15-25)24(40)41/h1-3,5-6,9,11,17-18,21H,4,7-8,10,12-15H2,(H,40,41) FKJUIKKANHHJKI-UHFFFAOYSA-N 382467 US10273259, Example 176 Nuclear receptor ROR-gamma Mus musculus 70.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382467&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 138592460 404851836 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765078 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C32H32F7NO5S/c1-2-18-3-7-23(8-4-18)46(44,45)29-11-12-40(26(41)20-14-28(15-20)16-21(17-28)27(42)43)25(29)10-5-19-13-22(6-9-24(19)29)30(33,31(34,35)36)32(37,38)39/h3-4,6-9,13,20-21,25H,2,5,10-12,14-17H2,1H3,(H,42,43) ABLUPHLRENFCNH-UHFFFAOYSA-N 382468 US10273259, Example 177::US10273259, Example 178::US10711020, Example 178 Nuclear receptor ROR-gamma Mus musculus 99.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382468&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 138592461 404851837 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765079 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C32H32F7NO5S/c1-2-18-3-7-23(8-4-18)46(44,45)29-11-12-40(26(41)20-14-28(15-20)16-21(17-28)27(42)43)25(29)10-5-19-13-22(6-9-24(19)29)30(33,31(34,35)36)32(37,38)39/h3-4,6-9,13,20-21,25H,2,5,10-12,14-17H2,1H3,(H,42,43) ABLUPHLRENFCNH-UHFFFAOYSA-N 382468 US10273259, Example 177::US10273259, Example 178::US10711020, Example 178 Nuclear receptor ROR-gamma Mus musculus 79.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382468&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 138592461 404851837 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765080 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C27H27F7N2O5S2/c1-23(10-14-42(38,39)15-11-23)22(37)36-13-9-24(43(40,41)21-4-2-3-12-35-21)19-7-6-18(16-17(19)5-8-20(24)36)25(28,26(29,30)31)27(32,33)34/h2-4,6-7,12,16,20H,5,8-11,13-15H2,1H3 QYXGXJIPIUURBV-UHFFFAOYSA-N 382470 US10273259, Example 179::US10711020, Example 179 Nuclear receptor ROR-gamma Mus musculus 132 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382470&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678605 404851838 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765081 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42) RGXXEOFNVGRMPO-UHFFFAOYSA-N 382471 US10273259, Example 180::US10711020, Example 182 Nuclear receptor ROR-gamma Mus musculus 35.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382471&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679078 404851839 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765082 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccccn2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H25F7N2O5S2/c27-24(25(28,29)30,26(31,32)33)18-5-6-19-17(15-18)4-7-20-23(19,42(39,40)21-3-1-2-11-34-21)10-12-35(20)22(36)16-8-13-41(37,38)14-9-16/h1-3,5-6,11,15-16,20H,4,7-10,12-14H2 GMYAHKGUKTUYTI-UHFFFAOYSA-N 382404 US10273259, Example 116::US10273259, Example 181::US10711020, Example 116 Nuclear receptor ROR-gamma Mus musculus 121 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382404&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678791 404851774 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765083 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42) RGXXEOFNVGRMPO-UHFFFAOYSA-N 382473 US10273259, Example 182 Nuclear receptor ROR-gamma Mus musculus 72.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382473&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679078 404851840 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765084 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccn1 InChI=1S/C26H25F7N2O6S2/c27-24(25(28,29)30,26(31,32)33)17-5-6-18-16(15-17)4-7-19-23(18,43(40,41)20-3-1-2-11-34-20)8-12-35(19)21(36)22(37)9-13-42(38,39)14-10-22/h1-3,5-6,11,15,19,37H,4,7-10,12-14H2 WJJYJLVRZNZANL-UHFFFAOYSA-N 382474 US10273259, Example 183::US10711020, Example 183 Nuclear receptor ROR-gamma Mus musculus 37.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382474&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678691 404851841 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765085 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C27H26F7NO5S2/c1-16-2-6-20(7-3-16)42(39,40)24-11-12-35(23(36)18-10-13-41(37,38)15-18)22(24)9-4-17-14-19(5-8-21(17)24)25(28,26(29,30)31)27(32,33)34/h2-3,5-8,14,18,22H,4,9-13,15H2,1H3 JCZODKLTPOVXKK-UHFFFAOYSA-N 382475 US10273259, Example 184::US10711020, Example 184 Nuclear receptor ROR-gamma Mus musculus 31.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382475&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 138592512 404851842 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765086 FC(F)(F)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C27H23F10NO5S2/c28-24(26(32,33)34,27(35,36)37)18-4-7-20-15(13-18)1-8-21-23(20,10-11-38(21)22(39)16-9-12-44(40,41)14-16)45(42,43)19-5-2-17(3-6-19)25(29,30)31/h2-7,13,16,21H,1,8-12,14H2 BMEFUXGXMBLNNG-UHFFFAOYSA-N 382476 US10273259, Example 185::US10711020, Example 185 Nuclear receptor ROR-gamma Mus musculus 21.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382476&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123625 404851843 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765087 CCc1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C28H28F7NO5S2/c1-2-17-3-7-21(8-4-17)43(40,41)25-12-13-36(24(37)19-11-14-42(38,39)16-19)23(25)10-5-18-15-20(6-9-22(18)25)26(29,27(30,31)32)28(33,34)35/h3-4,6-9,15,19,23H,2,5,10-14,16H2,1H3 KXQQBYSAEDZSOY-UHFFFAOYSA-N 382477 US10273259, Example 186::US10711020, Example 186 Nuclear receptor ROR-gamma Mus musculus 42.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382477&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679061 404851844 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765088 FC(F)(F)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H25F10NO5S2/c29-25(27(33,34)35,28(36,37)38)19-4-7-21-17(15-19)1-8-22-24(21,46(43,44)20-5-2-18(3-6-20)26(30,31)32)11-12-39(22)23(40)16-9-13-45(41,42)14-10-16/h2-7,15-16,22H,1,8-14H2 NMJDADYOTDMQRM-UHFFFAOYSA-N 382478 US10273259, Example 187::US10711020, Example 187 Nuclear receptor ROR-gamma Mus musculus 43.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382478&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678694 404851845 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765089 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccccn2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F InChI=1S/C25H23F7N2O5S2/c26-23(24(27,28)29,25(30,31)32)17-5-6-18-15(13-17)4-7-19-22(18,41(38,39)20-3-1-2-10-33-20)9-11-34(19)21(35)16-8-12-40(36,37)14-16/h1-3,5-6,10,13,16,19H,4,7-9,11-12,14H2 MJHVPJDIGHIQDH-UHFFFAOYSA-N 382479 US10273259, Example 188::US10711020, Example 188 Nuclear receptor ROR-gamma Mus musculus 63.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382479&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678696 404851846 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765090 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H25ClF7NO6S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-36(22(37)23(38)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,38H,1,8-14H2 QYPYNJHEHYAJCO-UHFFFAOYSA-N 382480 US10273259, Example 189::US10711020, Example 189 Nuclear receptor ROR-gamma Mus musculus 41.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382480&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679044 404851847 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765091 CC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H27ClF7NO5S2/c1-24(11-14-43(39,40)15-12-24)23(38)37-13-10-25(44(41,42)20-6-4-19(29)5-7-20)21-8-3-18(16-17(21)2-9-22(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,16,22H,2,9-15H2,1H3 IKMGSFDIFWQQER-UHFFFAOYSA-N 382481 US10273259, Example 190::US10711020, Example 190 Nuclear receptor ROR-gamma Mus musculus 20.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382481&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678702 404851848 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765092 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2 MXSYEHXMCRTPGX-UHFFFAOYSA-N 382482 US10273259, Example 191 Nuclear receptor ROR-gamma Mus musculus 9.00 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382482&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678606 404851849 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765093 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2 MXSYEHXMCRTPGX-UHFFFAOYSA-N 382483 US10273259, Example 192::US10273259, Example 193::US10711020, Example 193 Nuclear receptor ROR-gamma Mus musculus 21.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382483&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678606 404851850 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765094 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)C2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2 MXSYEHXMCRTPGX-UHFFFAOYSA-N 382483 US10273259, Example 192::US10273259, Example 193::US10711020, Example 193 Nuclear receptor ROR-gamma Mus musculus 21.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382483&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678606 404851850 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765095 CC(C)N1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O4S/c1-16(2)39-22(10-12-24(39)40)25(41)38-14-13-26(44(42,43)20-7-5-19(30)6-8-20)21-9-4-18(15-17(21)3-11-23(26)38)27(31,28(32,33)34)29(35,36)37/h4-9,15-16,22-23H,3,10-14H2,1-2H3/t22-,23?,26?/m0/s1 KFUALJWIARVOTP-MFNHVEPQSA-N 382485 US10273259, Example 194::US10711020, Example 194 Nuclear receptor ROR-gamma Mus musculus 162 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382485&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678936 404851851 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765096 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F7NO5S/c1-17-3-2-4-22(15-17)44(42,43)27-13-14-38(25(39)18-5-7-19(8-6-18)26(40)41)24(27)12-9-20-16-21(10-11-23(20)27)28(31,29(32,33)34)30(35,36)37/h2-4,10-11,15-16,18-19,24H,5-9,12-14H2,1H3,(H,40,41)/t18-,19-,24?,27? UCLOLQONKUCIPI-QXIWJBPRSA-N 382486 US10273259, Example 195::US10711020, Example 195 Nuclear receptor ROR-gamma Mus musculus 49.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382486&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123482 404851852 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765097 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F7NO5S/c1-19-3-2-4-22(17-19)46(44,45)29-15-16-40(25(41)27-9-12-28(13-10-27,14-11-27)26(42)43)24(29)8-5-20-18-21(6-7-23(20)29)30(33,31(34,35)36)32(37,38)39/h2-4,6-7,17-18,24H,5,8-16H2,1H3,(H,42,43) PZMOQFDJYDGCBV-UHFFFAOYSA-N 382487 US10273259, Example 196::US10711020, Example 196 Nuclear receptor ROR-gamma Mus musculus 43.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382487&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123502 404851853 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765098 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCC(=O)N1Cc1ccc(cc1)C#N InChI=1S/C35H30F7N3O4S/c1-21-3-2-4-26(17-21)50(48,49)32-15-16-44(31(47)28-12-14-30(46)45(28)20-23-7-5-22(19-43)6-8-23)29(32)13-9-24-18-25(10-11-27(24)32)33(36,34(37,38)39)35(40,41)42/h2-8,10-11,17-18,28-29H,9,12-16,20H2,1H3/t28-,29?,32?/m0/s1 RTPQBZCQABROSE-SLIGCLJVSA-N 382488 US10273259, Example 197::US10711020, Example 197 Nuclear receptor ROR-gamma Mus musculus 40.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382488&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123727 404851854 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765099 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(C)c1 InChI=1S/C28H27F7N2O4S/c1-16-4-3-5-19(14-16)42(40,41)25-12-13-37(24(39)21-9-11-23(38)36(21)2)22(25)10-6-17-15-18(7-8-20(17)25)26(29,27(30,31)32)28(33,34)35/h3-5,7-8,14-15,21-22H,6,9-13H2,1-2H3/t21-,22?,25?/m0/s1 MVLVBWCMWKBUDK-LBXYRFPKSA-N 382489 US10273259, Example 198::US10273259, Example 199::US10711020, Example 199 Nuclear receptor ROR-gamma Mus musculus 45.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382489&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678701 404851855 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765100 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(C)c1 InChI=1S/C28H27F7N2O4S/c1-16-4-3-5-19(14-16)42(40,41)25-12-13-37(24(39)21-9-11-23(38)36(21)2)22(25)10-6-17-15-18(7-8-20(17)25)26(29,27(30,31)32)28(33,34)35/h3-5,7-8,14-15,21-22H,6,9-13H2,1-2H3/t21-,22?,25?/m0/s1 MVLVBWCMWKBUDK-LBXYRFPKSA-N 382489 US10273259, Example 198::US10273259, Example 199::US10711020, Example 199 Nuclear receptor ROR-gamma Mus musculus 41.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382489&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678701 404851855 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765101 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H28F7NO5S2/c1-17-3-2-4-21(15-17)43(40,41)25-11-12-36(24(37)18-9-13-42(38,39)14-10-18)23(25)8-5-19-16-20(6-7-22(19)25)26(29,27(30,31)32)28(33,34)35/h2-4,6-7,15-16,18,23H,5,8-14H2,1H3 BZYBMICTADZPGU-UHFFFAOYSA-N 382491 US10273259, Example 200::US10711020, Example 200 Nuclear receptor ROR-gamma Mus musculus 143 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382491&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123481 404851856 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765102 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(C)CCS(=O)(=O)CC1 InChI=1S/C29H30F7NO5S2/c1-18-4-3-5-21(16-18)44(41,42)26-10-13-37(24(38)25(2)11-14-43(39,40)15-12-25)23(26)9-6-19-17-20(7-8-22(19)26)27(30,28(31,32)33)29(34,35)36/h3-5,7-8,16-17,23H,6,9-15H2,1-2H3 XOJBDZKNWQXWLC-UHFFFAOYSA-N 382492 US10273259, Example 201::US10711020, Example 201 Nuclear receptor ROR-gamma Mus musculus 141 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382492&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123503 404851857 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765103 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCC(CC1)C(O)=O InChI=1S/C30H30F7NO6S/c1-17-3-2-4-21(15-17)45(43,44)27-13-14-38(25(41)26(42)11-9-18(10-12-26)24(39)40)23(27)8-5-19-16-20(6-7-22(19)27)28(31,29(32,33)34)30(35,36)37/h2-4,6-7,15-16,18,23,42H,5,8-14H2,1H3,(H,39,40) SIEJUYOUEAJNOR-UHFFFAOYSA-N 382493 US10273259, Example 202::US10711020, Example 202 Nuclear receptor ROR-gamma Mus musculus 204 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382493&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123505 404851858 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765104 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F7NO5S/c1-18-4-3-5-22(16-18)45(43,44)28-14-15-39(26(42)27(2)12-10-19(11-13-27)25(40)41)24(28)9-6-20-17-21(7-8-23(20)28)29(32,30(33,34)35)31(36,37)38/h3-5,7-8,16-17,19,24H,6,9-15H2,1-2H3,(H,40,41)/t19-,24?,27-,28? YLTAZSBNSYXNGO-XJNMGFQWSA-N 382494 US10273259, Example 203::US10711020, Example 203 Nuclear receptor ROR-gamma Mus musculus 68.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382494&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123504 404851859 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765105 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC(C)(C)O InChI=1S/C27H28F7NO4S/c1-16-5-4-6-19(13-16)40(38,39)24-11-12-35(22(36)15-23(2,3)37)21(24)10-7-17-14-18(8-9-20(17)24)25(28,26(29,30)31)27(32,33)34/h4-6,8-9,13-14,21,37H,7,10-12,15H2,1-3H3 PFYZSCUZQWTTQR-UHFFFAOYSA-N 382495 US10273259, Example 204::US10711020, Example 204 Nuclear receptor ROR-gamma Mus musculus 79.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382495&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122680844 404851860 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765106 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCC(=O)N1Cc1ccc(cc1)C#N InChI=1S/C34H27F8N3O4S/c35-24-2-1-3-25(17-24)50(48,49)31-14-15-44(30(47)27-11-13-29(46)45(27)19-21-6-4-20(18-43)5-7-21)28(31)12-8-22-16-23(9-10-26(22)31)32(36,33(37,38)39)34(40,41)42/h1-7,9-10,16-17,27-28H,8,11-15,19H2/t27-,28?,31?/m0/s1 FAXVEERWTHXMMC-XFXVWLJXSA-N 382496 US10273259, Example 205::US10711020, Example 205 Nuclear receptor ROR-gamma Mus musculus 136 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382496&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123831 404851861 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765107 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H24F8N2O4S/c1-36-20(8-10-22(36)38)23(39)37-12-11-24(42(40,41)18-4-2-3-17(28)14-18)19-7-6-16(13-15(19)5-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-4,6-7,13-14,20-21H,5,8-12H2,1H3/t20-,21?,24?/m0/s1 JPICNJJDAWWROI-MFMCRYCZSA-N 382497 US10273259, Example 206::US10273259, Example 207::US10711020, Example 207 Nuclear receptor ROR-gamma Mus musculus 59.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382497&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679029 404851862 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765108 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H24F8N2O4S/c1-36-20(8-10-22(36)38)23(39)37-12-11-24(42(40,41)18-4-2-3-17(28)14-18)19-7-6-16(13-15(19)5-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-4,6-7,13-14,20-21H,5,8-12H2,1H3/t20-,21?,24?/m0/s1 JPICNJJDAWWROI-MFMCRYCZSA-N 382497 US10273259, Example 206::US10273259, Example 207::US10711020, Example 207 Nuclear receptor ROR-gamma Mus musculus 54.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382497&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679029 404851862 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765109 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(Cl)c2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H25ClF7NO5S2/c28-19-2-1-3-20(15-19)43(40,41)24-10-11-36(23(37)16-8-12-42(38,39)13-9-16)22(24)7-4-17-14-18(5-6-21(17)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,14-16,22H,4,7-13H2 CUKKBZSRYISQBH-UHFFFAOYSA-N 382499 US10273259, Example 208::US10711020, Example 208 Nuclear receptor ROR-gamma Mus musculus 38.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382499&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678937 404851863 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765110 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H27ClF7NO6S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-38(24(41)25(42)10-8-16(9-11-25)23(39)40)22(26)7-4-17-14-18(5-6-21(17)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-6,14-16,22,42H,4,7-13H2,(H,39,40)/t16-,22?,25+,26? OWQNPYOBRQKKOE-VXBFRIGJSA-N 382500 US10273259, Example 209::US10711020, Example 209 Nuclear receptor ROR-gamma Mus musculus 123 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382500&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678816 404851864 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765111 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H27ClF7NO5S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-38(24(39)16-4-6-17(7-5-16)25(40)41)23(26)11-8-18-14-19(9-10-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,40,41)/t16-,17-,23?,26? CFTRQLKAHBITQD-LRVXPCDCSA-N 382501 US10273259, Example 210::US10711020, Example 210 Nuclear receptor ROR-gamma Mus musculus 24.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382501&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678941 404851865 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765112 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C31H29ClF7NO5S/c32-20-2-1-3-21(17-20)46(44,45)28-14-15-40(24(41)26-8-11-27(12-9-26,13-10-26)25(42)43)23(28)7-4-18-16-19(5-6-22(18)28)29(33,30(34,35)36)31(37,38)39/h1-3,5-6,16-17,23H,4,7-15H2,(H,42,43) YAPKXGXXZUYCIH-UHFFFAOYSA-N 382502 US10273259, Example 211::US10711020, Example 211 Nuclear receptor ROR-gamma Mus musculus 22.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382502&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678707 404851866 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765113 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C27H24ClF7N2O4S/c1-36-20(8-10-22(36)38)23(39)37-12-11-24(42(40,41)18-4-2-3-17(28)14-18)19-7-6-16(13-15(19)5-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-4,6-7,13-14,20-21H,5,8-12H2,1H3/t20-,21?,24?/m0/s1 MIZXAOSVPMWBEM-MFMCRYCZSA-N 382503 US10273259, Example 212::US10273259, Example 213::US10711020, Example 213 Nuclear receptor ROR-gamma Mus musculus 22.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382503&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678817 404851867 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765114 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C27H24ClF7N2O4S/c1-36-20(8-10-22(36)38)23(39)37-12-11-24(42(40,41)18-4-2-3-17(28)14-18)19-7-6-16(13-15(19)5-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-4,6-7,13-14,20-21H,5,8-12H2,1H3/t20-,21?,24?/m0/s1 MIZXAOSVPMWBEM-MFMCRYCZSA-N 382503 US10273259, Example 212::US10273259, Example 213::US10711020, Example 213 Nuclear receptor ROR-gamma Mus musculus 97.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382503&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678817 404851867 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765115 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(Cl)c2)C(=O)[C@@H]2CCC(=O)N2Cc2ccc(cc2)C#N)c1)C(F)(F)F InChI=1S/C34H27ClF7N3O4S/c35-24-2-1-3-25(17-24)50(48,49)31-14-15-44(30(47)27-11-13-29(46)45(27)19-21-6-4-20(18-43)5-7-21)28(31)12-8-22-16-23(9-10-26(22)31)32(36,33(37,38)39)34(40,41)42/h1-7,9-10,16-17,27-28H,8,11-15,19H2/t27-,28?,31?/m0/s1 SHLJQZILEURESG-XFXVWLJXSA-N 382505 US10273259, Example 214::US10711020, Example 214 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382505&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679026 404851868 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765116 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H26ClF8NO5S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-39(24(42)25(31)10-8-16(9-11-25)23(40)41)22(26)7-4-17-14-18(5-6-21(17)26)27(32,28(33,34)35)29(36,37)38/h1-3,5-6,14-16,22H,4,7-13H2,(H,40,41)/t16-,22?,25+,26? BFEDNCMUXBBKEB-VXBFRIGJSA-N 382506 US10273259, Example 215::US10711020, Example 215 Nuclear receptor ROR-gamma Mus musculus 92.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382506&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678456 404851869 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765117 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C29H26ClF8NO5S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-39(23(40)16-8-10-25(31,11-9-16)24(41)42)22(26)7-4-17-14-18(5-6-21(17)26)27(32,28(33,34)35)29(36,37)38/h1-3,5-6,14-16,22H,4,7-13H2,(H,41,42)/t16-,22?,25+,26? FTJWEFHBTUWKLO-VXBFRIGJSA-N 382507 US10273259, Example 216::US10711020, Example 216 Nuclear receptor ROR-gamma Mus musculus 111 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382507&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678429 404851870 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765118 Cc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-17-3-2-4-21(15-17)45(43,44)27-13-14-39(25(42)26(31)11-9-18(10-12-26)24(40)41)23(27)8-5-19-16-20(6-7-22(19)27)28(32,29(33,34)35)30(36,37)38/h2-4,6-7,15-16,18,23H,5,8-14H2,1H3,(H,40,41)/t18-,23?,26+,27? RIZHVHAYTAMLNT-MJALUPOVSA-N 382508 US10273259, Example 217::US10711020, Example 217 Nuclear receptor ROR-gamma Mus musculus 95.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382508&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123778 404851871 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765119 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(Cl)c1 InChI=1S/C30H29ClF7NO5S/c1-26(11-9-17(10-12-26)24(40)41)25(42)39-14-13-27(45(43,44)21-4-2-3-20(31)16-21)22-7-6-19(15-18(22)5-8-23(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,6-7,15-17,23H,5,8-14H2,1H3,(H,40,41)/t17-,23?,26-,27? NCIMWYXTFMBJEU-PYPIJRSMSA-N 382509 US10273259, Example 218::US10711020, Example 218 Nuclear receptor ROR-gamma Mus musculus 216 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382509&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678542 404851872 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765120 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCC(=O)N1Cc1ccc(cc1)C#N InChI=1S/C34H27F8N3O4S/c35-24-7-9-25(10-8-24)50(48,49)31-15-16-44(30(47)27-12-14-29(46)45(27)19-21-3-1-20(18-43)2-4-21)28(31)13-5-22-17-23(6-11-26(22)31)32(36,33(37,38)39)34(40,41)42/h1-4,6-11,17,27-28H,5,12-16,19H2/t27-,28+,31+/m0/s1 LUUKHFWCCAZXEK-WTNLLYQRSA-N 382510 US10273259, Example 219::US10711020, Example 219 Nuclear receptor ROR-gamma Mus musculus 135 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382510&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679035 404851873 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765121 CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O4S/c1-36-20(9-11-22(36)38)23(39)37-13-12-24(42(40,41)18-6-4-17(28)5-7-18)19-8-3-16(14-15(19)2-10-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,14,20-21H,2,9-13H2,1H3/t20-,21+,24+/m0/s1 SWQNFSBHLVEMAL-YZUZCNPQSA-N 382511 US10273259, Example 220::US10273259, Example 222::US10711020, Example 222 Nuclear receptor ROR-gamma Mus musculus 31.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382511&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678945 404851874 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765122 CC(C)(O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c1-22(2,37)14-21(36)35-12-11-23(40(38,39)18-7-5-17(27)6-8-18)19-9-4-16(13-15(19)3-10-20(23)35)24(28,25(29,30)31)26(32,33)34/h4-9,13,20,37H,3,10-12,14H2,1-2H3/t20-,23-/m1/s1 FAZFPWKELKKKPT-NFBKMPQASA-N 382512 US10273259, Example 221::US10711020, Example 221 Nuclear receptor ROR-gamma Mus musculus 27.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382512&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678819 404851875 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765123 CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O4S/c1-36-20(9-11-22(36)38)23(39)37-13-12-24(42(40,41)18-6-4-17(28)5-7-18)19-8-3-16(14-15(19)2-10-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,14,20-21H,2,9-13H2,1H3/t20-,21+,24+/m0/s1 SWQNFSBHLVEMAL-YZUZCNPQSA-N 382511 US10273259, Example 220::US10273259, Example 222::US10711020, Example 222 Nuclear receptor ROR-gamma Mus musculus 30.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382511&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678945 404851874 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765124 CCN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-2-37-21(10-12-23(37)39)24(40)38-14-13-25(43(41,42)19-7-5-18(29)6-8-19)20-9-4-17(15-16(20)3-11-22(25)38)26(30,27(31,32)33)28(34,35)36/h4-9,15,21-22H,2-3,10-14H2,1H3/t21-,22+,25+/m0/s1 LTSZYGRBVCICKD-SGIRGMQISA-N 382514 US10273259, Example 223::US10711020, Example 223 Nuclear receptor ROR-gamma Mus musculus 58.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382514&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678617 404851876 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765125 Fc1ccc(CN2[C@@H](CCC2=O)C(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C33H27F9N2O4S/c34-22-5-1-19(2-6-22)18-44-26(12-14-28(44)45)29(46)43-16-15-30(49(47,48)24-9-7-23(35)8-10-24)25-11-4-21(17-20(25)3-13-27(30)43)31(36,32(37,38)39)33(40,41)42/h1-2,4-11,17,26-27H,3,12-16,18H2/t26-,27+,30+/m0/s1 VEVVQCYACXKTGP-PVTPYKNESA-N 382515 US10273259, Example 224::US10711020, Example 224 Nuclear receptor ROR-gamma Mus musculus 129 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382515&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678614 404851877 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765126 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccnnc1 InChI=1S/C27H21F8N3O3S/c28-19-3-5-20(6-4-19)42(40,41)24-10-12-38(23(39)13-16-9-11-36-37-15-16)22(24)8-1-17-14-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,9,11,14-15,22H,1,8,10,12-13H2/t22-,24-/m1/s1 PTUBSSJVFTVOLU-ISKFKSNPSA-N 382516 US10273259, Example 225::US10711020, Example 225 Nuclear receptor ROR-gamma Mus musculus 114 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382516&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678609 404851878 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765127 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(Cl)c2)C(=O)Cc2ccnnc2)c1)C(F)(F)F InChI=1S/C27H21ClF7N3O3S/c28-19-2-1-3-20(14-19)42(40,41)24-9-11-38(23(39)12-16-8-10-36-37-15-16)22(24)7-4-17-13-18(5-6-21(17)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,8,10,13-15,22H,4,7,9,11-12H2 RCBBIBUSYNZLMW-UHFFFAOYSA-N 382517 US10273259, Example 226::US10711020, Example 226 Nuclear receptor ROR-gamma Mus musculus 145 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382517&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678946 404851879 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765128 CC(C)(O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H33F8NO4S/c1-27(2,42)20-6-3-18(4-7-20)26(41)40-16-15-28(45(43,44)23-11-9-22(32)10-12-23)24-13-8-21(17-19(24)5-14-25(28)40)29(33,30(34,35)36)31(37,38)39/h8-13,17-18,20,25,42H,3-7,14-16H2,1-2H3/t18-,20-,25-,28-/m1/s1 IBDGDPWJUBUPMH-CVODSWBYSA-N 382518 US10273259, Example 227::US10711020, Example 227 Nuclear receptor ROR-gamma Mus musculus 137 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382518&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679049 404851880 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765129 CC(C)(O)C12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C33H35F8NO4S/c1-27(2,44)29-14-11-28(12-15-29,13-16-29)26(43)42-18-17-30(47(45,46)23-7-5-22(34)6-8-23)24-9-4-21(19-20(24)3-10-25(30)42)31(35,32(36,37)38)33(39,40)41/h4-9,19,25,44H,3,10-18H2,1-2H3/t25-,28?,29?,30-/m1/s1 CDRGPHDRUUQNEB-SBIUAKNBSA-N 382519 US10273259, Example 228::US10711020, Example 228 Nuclear receptor ROR-gamma Mus musculus 464 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382519&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678610 404851881 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765130 OC(=O)c1cc([nH]n1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 382520 US10273259, Example 229::US10711020, Example 229 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382520&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678622 404851882 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765131 CN1[C@@H](C[C@@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F9N2O4S/c1-37-20(13-19(29)22(37)39)23(40)38-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)38)25(30,26(31,32)33)27(34,35)36/h3-8,12,19-21H,2,9-11,13H2,1H3/t19-,20+,21-,24-/m1/s1 PDJZLHFYLDTXLV-OOICKAIWSA-N 382521 US10273259, Example 230::US10711020, Example 230 Nuclear receptor ROR-gamma Mus musculus 175 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382521&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995590 404851883 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765132 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F9N2O4S/c1-37-20(13-19(29)22(37)39)23(40)38-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)38)25(30,26(31,32)33)27(34,35)36/h3-8,12,19-21H,2,9-11,13H2,1H3/t19-,20-,21+,24+/m0/s1 PDJZLHFYLDTXLV-VMIIQTFKSA-N 382522 US10273259, Example 231::US10273259, Example 243::US10711020, Example 243 Nuclear receptor ROR-gamma Mus musculus 68.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382522&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678541 404851884 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765133 CN1[C@@H](CC(F)(F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H22F10N2O4S/c1-38-19(13-24(29,30)22(38)41)21(40)39-11-10-23(44(42,43)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-20(23)39)25(31,26(32,33)34)27(35,36)37/h3-8,12,19-20H,2,9-11,13H2,1H3/t19-,20+,23+/m0/s1 UENBCEQAMCZVQL-MIZPHKNDSA-N 382523 US10273259, Example 232::US10711020, Example 232 Nuclear receptor ROR-gamma Mus musculus 174 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382523&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995591 404851885 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765134 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H23ClF8N2O4S/c1-37-20(13-19(29)22(37)39)23(40)38-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)38)25(30,26(31,32)33)27(34,35)36/h3-8,12,19-21H,2,9-11,13H2,1H3/t19-,20-,21?,24?/m0/s1 MGBSTZNMVHLPCT-SZYSUKIFSA-N 382524 US10273259, Example 233::US10711020, Example 233 Nuclear receptor ROR-gamma Mus musculus 45.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382524&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995592 404851886 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765135 CN1[C@@H](CC(F)(F)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C27H22ClF9N2O4S/c1-38-19(13-24(29,30)22(38)41)21(40)39-11-10-23(44(42,43)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-20(23)39)25(31,26(32,33)34)27(35,36)37/h3-8,12,19-20H,2,9-11,13H2,1H3/t19-,20?,23?/m0/s1 WITOGCPDCBASFX-UDTLNKQYSA-N 382525 US10273259, Example 234::US10711020, Example 234 Nuclear receptor ROR-gamma Mus musculus 283 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382525&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995593 404851887 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765136 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H22F8N2O5S/c1-35-18(12-17(27)21(35)37)22(38)36-10-9-23(42(39,40)15-5-3-2-4-6-15)16-8-7-14(11-19(16)41-13-20(23)36)24(28,25(29,30)31)26(32,33)34/h2-8,11,17-18,20H,9-10,12-13H2,1H3/t17-,18-,20?,23?/m0/s1 SEMYZRMHEFTJLB-NEPPSICNSA-N 382526 US10273259, Example 235::US10711020, Example 235 Nuclear receptor ROR-gamma Mus musculus 53.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382526&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995594 404851888 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765137 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H24F8N2O4S/c1-36-20(14-19(28)22(36)38)23(39)37-12-11-24(42(40,41)17-5-3-2-4-6-17)18-9-8-16(13-15(18)7-10-21(24)37)25(29,26(30,31)32)27(33,34)35/h2-6,8-9,13,19-21H,7,10-12,14H2,1H3/t19-,20-,21+,24+/m0/s1 PEYOSKFVXLWXDJ-VMIIQTFKSA-N 382527 US10273259, Example 236::US10711020, Example 236 Nuclear receptor ROR-gamma Mus musculus 39.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382527&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995595 404851889 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765138 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H21F9N2O5S/c1-36-18(11-17(28)21(36)38)22(39)37-9-8-23(43(40,41)15-5-3-14(27)4-6-15)16-7-2-13(10-19(16)42-12-20(23)37)24(29,25(30,31)32)26(33,34)35/h2-7,10,17-18,20H,8-9,11-12H2,1H3/t17-,18-,20?,23?/m0/s1 AAGXBENZSYRCQC-NEPPSICNSA-N 382528 US10273259, Example 237::US10711020, Example 237 Nuclear receptor ROR-gamma Mus musculus 42.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382528&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995596 404851890 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765139 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C26H21ClF8N2O5S/c1-36-18(11-17(28)21(36)38)22(39)37-9-8-23(43(40,41)15-5-3-14(27)4-6-15)16-7-2-13(10-19(16)42-12-20(23)37)24(29,25(30,31)32)26(33,34)35/h2-7,10,17-18,20H,8-9,11-12H2,1H3/t17-,18-,20?,23?/m0/s1 ROGCQVPPXUJQNA-NEPPSICNSA-N 382529 US10273259, Example 238::US10711020, Example 238 Nuclear receptor ROR-gamma Mus musculus 71.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382529&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995597 404851891 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765140 CN1C(CCS1(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O5S2/c1-35-20(10-13-42(35,38)39)22(37)36-12-11-23(43(40,41)18-6-4-17(27)5-7-18)19-8-3-16(14-15(19)2-9-21(23)36)24(28,25(29,30)31)26(32,33)34/h3-8,14,20-21H,2,9-13H2,1H3/t20?,21-,23-/m1/s1 YFUKOVVZMSALOZ-CQQDSARBSA-N 382530 US10273259, Example 239::US10711020, Example 239 Nuclear receptor ROR-gamma Mus musculus 14.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382530&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995598 404851892 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765141 CN1CC(CC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O4S/c1-36-14-16(13-22(36)38)23(39)37-11-10-24(42(40,41)19-6-4-18(28)5-7-19)20-8-3-17(12-15(20)2-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,16,21H,2,9-11,13-14H2,1H3/t16?,21-,24-/m1/s1 HFWOMLYIVVVHFI-DKAGOCCWSA-N 382531 US10273259, Example 240::US10711020, Example 240 Nuclear receptor ROR-gamma Mus musculus 13.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382531&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995599 404851893 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765142 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC(=O)N1CCC#N InChI=1S/C29H25F8N3O4S/c30-19-4-6-20(7-5-19)45(43,44)26-12-15-40(25(42)22-9-11-24(41)39(22)14-1-13-38)23(26)10-2-17-16-18(3-8-21(17)26)27(31,28(32,33)34)29(35,36)37/h3-8,16,22-23H,1-2,9-12,14-15H2/t22?,23-,26-/m1/s1 XDDWLXGEQFTMIY-IQIYYKORSA-N 382532 US10273259, Example 241::US10711020, Example 241 Nuclear receptor ROR-gamma Mus musculus 36.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382532&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678947 404851894 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765143 CN1C(=O)CCC1(C)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-24(12-11-22(39)37(24)2)23(40)38-14-13-25(43(41,42)19-7-5-18(29)6-8-19)20-9-4-17(15-16(20)3-10-21(25)38)26(30,27(31,32)33)28(34,35)36/h4-9,15,21H,3,10-14H2,1-2H3/t21-,24?,25-/m1/s1 ULPQTSLOGZZSRD-TYIXABJVSA-N 382533 US10273259, Example 242::US10711020, Example 242 Nuclear receptor ROR-gamma Mus musculus 25.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382533&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995600 404851895 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765144 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F9N2O4S/c1-37-20(13-19(29)22(37)39)23(40)38-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)38)25(30,26(31,32)33)27(34,35)36/h3-8,12,19-21H,2,9-11,13H2,1H3/t19-,20-,21+,24+/m0/s1 PDJZLHFYLDTXLV-VMIIQTFKSA-N 382522 US10273259, Example 231::US10273259, Example 243::US10711020, Example 243 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382522&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678541 404851884 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765145 CC(C)N1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F9N2O4S/c1-15(2)40-22(14-21(31)24(40)41)25(42)39-12-11-26(45(43,44)19-7-5-18(30)6-8-19)20-9-4-17(13-16(20)3-10-23(26)39)27(32,28(33,34)35)29(36,37)38/h4-9,13,15,21-23H,3,10-12,14H2,1-2H3/t21-,22-,23+,26+/m0/s1 ZLVIPALKYFKUPO-OHTANWTRSA-N 382535 US10273259, Example 244::US10711020, Example 244 Nuclear receptor ROR-gamma Mus musculus 112 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382535&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678720 404851896 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765146 COCCN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F9N2O5S/c1-45-13-12-39-22(15-21(31)24(39)41)25(42)40-11-10-26(46(43,44)19-6-4-18(30)5-7-19)20-8-3-17(14-16(20)2-9-23(26)40)27(32,28(33,34)35)29(36,37)38/h3-8,14,21-23H,2,9-13,15H2,1H3/t21-,22-,23+,26+/m0/s1 IKFKMNGGPLUNSF-OHTANWTRSA-N 382536 US10273259, Example 245::US10711020, Example 245 Nuclear receptor ROR-gamma Mus musculus 54.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382536&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678823 404851897 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765147 CN1[C@@H](C[C@H](O)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c1-36-19(13-20(38)23(36)40)22(39)37-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,19-21,38H,2,9-11,13H2,1H3/t19-,20-,21+,24+/m0/s1 KAKUQEOIEAWDFB-VMIIQTFKSA-N 382537 US10273259, Example 246::US10273259, Example 494::US10711020, Example 494 Nuclear receptor ROR-gamma Mus musculus 46.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382537&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678788 404851898 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765148 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C31H29F8NO5S/c32-20-2-1-3-21(17-20)46(44,45)28-14-15-40(24(41)26-8-11-27(12-9-26,13-10-26)25(42)43)23(28)7-4-18-16-19(5-6-22(18)28)29(33,30(34,35)36)31(37,38)39/h1-3,5-6,16-17,23H,4,7-15H2,(H,42,43) QVKAWLKXDAVRSX-UHFFFAOYSA-N 382538 US10273259, Example 247::US10711020, Example 247 Nuclear receptor ROR-gamma Mus musculus 40.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382538&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679076 404851899 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765149 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H26F9NO5S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-39(24(42)25(31)10-8-16(9-11-25)23(40)41)22(26)7-4-17-14-18(5-6-21(17)26)27(32,28(33,34)35)29(36,37)38/h1-3,5-6,14-16,22H,4,7-13H2,(H,40,41)/t16-,22?,25+,26? ZOJNDSHZKIPWLY-VXBFRIGJSA-N 382539 US10273259, Example 248::US10711020, Example 248 Nuclear receptor ROR-gamma Mus musculus 34.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382539&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678950 404851900 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765150 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H29F8NO5S/c1-26(11-9-17(10-12-26)24(40)41)25(42)39-14-13-27(45(43,44)21-4-2-3-20(31)16-21)22-7-6-19(15-18(22)5-8-23(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,6-7,15-17,23H,5,8-14H2,1H3,(H,40,41)/t17-,23?,26-,27? IAEWJYSPAAAVCL-PYPIJRSMSA-N 382540 US10273259, Example 249::US10711020, Example 249 Nuclear receptor ROR-gamma Mus musculus 68.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382540&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679060 404851901 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765151 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-19-2-1-3-20(15-19)43(40,41)24-10-11-36(23(37)16-8-12-42(38,39)13-9-16)22(24)7-4-17-14-18(5-6-21(17)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,14-16,22H,4,7-13H2 OBOQQJZBXHFEFQ-UHFFFAOYSA-N 382541 US10273259, Example 250::US10273259, Example 253::US10711020, Example 253 Nuclear receptor ROR-gamma Mus musculus 46.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382541&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678598 404851902 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765152 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H27F8NO6S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-38(24(41)25(42)10-8-16(9-11-25)23(39)40)22(26)7-4-17-14-18(5-6-21(17)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-6,14-16,22,42H,4,7-13H2,(H,39,40)/t16-,22?,25+,26? CYSYXHPBNQFPED-VXBFRIGJSA-N 382542 US10273259, Example 251::US10711020, Example 251 Nuclear receptor ROR-gamma Mus musculus 54.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382542&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679040 404851903 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765153 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H27F8NO5S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-38(24(39)16-4-6-17(7-5-16)25(40)41)23(26)11-8-18-14-19(9-10-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,40,41)/t16-,17-,23?,26? LIWMGZMUBKUREU-LRVXPCDCSA-N 382543 US10273259, Example 252::US10711020, Example 265 Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382543&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679068 404851904 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765154 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-19-2-1-3-20(15-19)43(40,41)24-10-11-36(23(37)16-8-12-42(38,39)13-9-16)22(24)7-4-17-14-18(5-6-21(17)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,14-16,22H,4,7-13H2 OBOQQJZBXHFEFQ-UHFFFAOYSA-N 382541 US10273259, Example 250::US10273259, Example 253::US10711020, Example 253 Nuclear receptor ROR-gamma Mus musculus 3556 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382541&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678598 404851902 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765155 OC(=O)C12CCC(CC1)(CO2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO6S/c31-19-3-5-20(6-4-19)46(43,44)27-13-14-39(23(40)25-9-11-26(12-10-25,24(41)42)45-16-25)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,22H,1,8-14,16H2,(H,41,42)/t22-,25?,26?,27-/m1/s1 OFTMRBWXEACVFZ-LPDNJITPSA-N 382545 US10273259, Example 254::US10711020, Example 254 Nuclear receptor ROR-gamma Mus musculus 84.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382545&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678615 404851905 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765156 OC(=O)C12CCC(CC1)(OC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO6S/c31-19-3-5-20(6-4-19)46(43,44)27-13-14-39(23(40)26-11-9-25(10-12-26,16-45-26)24(41)42)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,22H,1,8-14,16H2,(H,41,42)/t22-,25?,26?,27-/m1/s1 RVUSZWSBSZBUBX-LPDNJITPSA-N 382546 US10273259, Example 255::US10711020, Example 255 Nuclear receptor ROR-gamma Mus musculus 24.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382546&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678952 404851906 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765157 OC(=O)C12CCC(CC1)(OC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO6S/c31-19-3-5-20(6-4-19)46(43,44)27-13-14-39(23(40)26-11-9-25(10-12-26,16-45-26)24(41)42)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,22H,1,8-14,16H2,(H,41,42) VKVORPFBSUVVNV-UHFFFAOYSA-N 382547 US10273259, Example 256::US10711020, Example 256 Nuclear receptor ROR-gamma Mus musculus 324 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382547&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678616 404851907 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765158 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42) RGXXEOFNVGRMPO-UHFFFAOYSA-N 382548 US10273259, Example 257 Nuclear receptor ROR-gamma Mus musculus 124 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382548&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679078 404851908 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765159 CN1CCC(CC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-37-12-10-17(15-23(37)39)24(40)38-13-11-25(43(41,42)20-6-4-19(29)5-7-20)21-8-3-18(14-16(21)2-9-22(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,14,17,22H,2,9-13,15H2,1H3/t17?,22-,25-/m1/s1 YDBZXBHDAXQLST-MUNXEIQQSA-N 382549 US10273259, Example 258::US10711020, Example 258 Nuclear receptor ROR-gamma Mus musculus 12.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382549&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678458 404851909 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765160 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H25F8NO6S2/c28-18-2-1-3-19(15-18)44(41,42)24-8-11-36(22(37)23(38)9-12-43(39,40)13-10-23)21(24)7-4-16-14-17(5-6-20(16)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,14-15,21,38H,4,7-13H2 SURGLXFVHQGKJJ-UHFFFAOYSA-N 382550 US10273259, Example 259::US10711020, Example 259 Nuclear receptor ROR-gamma Mus musculus 75.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382550&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678951 404851910 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765161 CC(C)(CC(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(O)=O InChI=1S/C27H25F8NO5S/c1-23(2,22(38)39)14-21(37)36-11-10-24(42(40,41)18-5-3-4-17(28)13-18)19-8-7-16(12-15(19)6-9-20(24)36)25(29,26(30,31)32)27(33,34)35/h3-5,7-8,12-13,20H,6,9-11,14H2,1-2H3,(H,38,39) WENPJLVMTZTJFZ-UHFFFAOYSA-N 382551 US10273259, Example 260::US10711020, Example 260 Nuclear receptor ROR-gamma Mus musculus 75.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382551&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679054 404851911 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765162 OC(=O)[C@]1(O)CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H27F8NO6S/c30-19-2-1-3-20(15-19)45(43,44)26-12-13-38(23(39)16-8-10-25(42,11-9-16)24(40)41)22(26)7-4-17-14-18(5-6-21(17)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-6,14-16,22,42H,4,7-13H2,(H,40,41)/t16-,22?,25-,26? QIVQLOROWZUEMV-FVSSTLBOSA-N 382552 US10273259, Example 261::US10711020, Example 261 Nuclear receptor ROR-gamma Mus musculus 115 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382552&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679048 404851912 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765163 CC(C)[C@@H](CC(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(O)=O InChI=1S/C28H27F8NO5S/c1-15(2)20(24(39)40)14-23(38)37-11-10-25(43(41,42)19-5-3-4-18(29)13-19)21-8-7-17(12-16(21)6-9-22(25)37)26(30,27(31,32)33)28(34,35)36/h3-5,7-8,12-13,15,20,22H,6,9-11,14H2,1-2H3,(H,39,40)/t20-,22?,25?/m1/s1 ICFMTTWVAHXYNR-HUFXOUDFSA-N 382553 US10273259, Example 262::US10711020, Example 262 Nuclear receptor ROR-gamma Mus musculus 69.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382553&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678832 404851913 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765164 OC(=O)CC(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C24H19F8NO5S/c25-15-2-1-3-16(11-15)39(37,38)21-8-9-33(19(34)12-20(35)36)18(21)7-4-13-10-14(5-6-17(13)21)22(26,23(27,28)29)24(30,31)32/h1-3,5-6,10-11,18H,4,7-9,12H2,(H,35,36) CLOWCGWHESTLIG-UHFFFAOYSA-N 382554 US10273259, Example 263::US10711020, Example 263 Nuclear receptor ROR-gamma Mus musculus 648 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382554&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678954 404851914 C01656 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765165 CC(C)(CC(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H25F8NO5S/c1-23(2,14-21(37)38)22(39)36-11-10-24(42(40,41)18-5-3-4-17(28)13-18)19-8-7-16(12-15(19)6-9-20(24)36)25(29,26(30,31)32)27(33,34)35/h3-5,7-8,12-13,20H,6,9-11,14H2,1-2H3,(H,37,38) WDBWWFALMRQCBC-UHFFFAOYSA-N 382555 US10273259, Example 264::US10711020, Example 264 Nuclear receptor ROR-gamma Mus musculus 16.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382555&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678504 404851915 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765166 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H27F8NO5S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-38(24(39)16-4-6-17(7-5-16)25(40)41)23(26)11-8-18-14-19(9-10-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,40,41)/t16-,17-,23?,26? LIWMGZMUBKUREU-LRVXPCDCSA-N 382556 US10273259, Example 265 Nuclear receptor ROR-gamma Mus musculus 3098 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382556&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679068 404851916 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765167 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(Br)ccc21)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C26H28BrNO6S/c1-16-2-9-20(10-3-16)35(32,33)26-12-13-28(24(29)17-4-6-18(7-5-17)25(30)31)23(26)15-34-22-14-19(27)8-11-21(22)26/h2-3,8-11,14,17-18,23H,4-7,12-13,15H2,1H3,(H,30,31)/t17-,18-,23?,26? AFINFWAWCZYKJF-GIHSMNABSA-N 382557 US10273259, Example 266::US10711020, Example 266 Nuclear receptor ROR-gamma Mus musculus 1652 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382557&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678539 404851917 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765168 Cc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(Br)ccc21)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C28H30BrNO6S/c1-18-2-5-20(6-3-18)37(34,35)28-14-15-30(23(28)17-36-22-16-19(29)4-7-21(22)28)24(31)26-8-11-27(12-9-26,13-10-26)25(32)33/h2-7,16,23H,8-15,17H2,1H3,(H,32,33) WSRCYQFNPFFCMX-UHFFFAOYSA-N 382558 US10273259, Example 267::US10711020, Example 267 Nuclear receptor ROR-gamma Mus musculus 182 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382558&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678501 404851918 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765169 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(Br)ccc21)S(=O)(=O)c1cccc(F)c1 InChI=1S/C26H27BrFNO5S/c27-19-9-10-22-18(14-19)8-11-23-26(22,35(33,34)21-3-1-2-20(28)15-21)12-13-29(23)24(30)16-4-6-17(7-5-16)25(31)32/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,31,32)/t16-,17-,23?,26? FLUGMCIXCKJUHH-LRVXPCDCSA-N 382559 US10273259, Example 268::US10711020, Example 268 Nuclear receptor ROR-gamma Mus musculus 108 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382559&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679071 404851919 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765170 CC(C)(C)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(F)c2)C(=O)[C@H]2CC[C@@H](CC2)C(O)=O)c1 InChI=1S/C30H36FNO5S/c1-29(2,3)22-12-13-25-21(17-22)11-14-26-30(25,38(36,37)24-6-4-5-23(31)18-24)15-16-32(26)27(33)19-7-9-20(10-8-19)28(34)35/h4-6,12-13,17-20,26H,7-11,14-16H2,1-3H3,(H,34,35)/t19-,20-,26?,30? NRSPFIZINSCLCX-XZJQCRQJSA-N 382560 US10273259, Example 269::US10273259, Example 270::US10711020, Example 270 Nuclear receptor ROR-gamma Mus musculus 44.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382560&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678464 404851920 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765171 CC(C)(C)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(F)c2)C(=O)[C@H]2CC[C@@H](CC2)C(O)=O)c1 InChI=1S/C30H36FNO5S/c1-29(2,3)22-12-13-25-21(17-22)11-14-26-30(25,38(36,37)24-6-4-5-23(31)18-24)15-16-32(26)27(33)19-7-9-20(10-8-19)28(34)35/h4-6,12-13,17-20,26H,7-11,14-16H2,1-3H3,(H,34,35)/t19-,20-,26?,30? NRSPFIZINSCLCX-XZJQCRQJSA-N 382560 US10273259, Example 269::US10273259, Example 270::US10711020, Example 270 Nuclear receptor ROR-gamma Mus musculus 3430 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382560&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678464 404851920 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765172 CC(C)(C)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(F)c2)C(=O)C23CCC(CC2)(CC3)C(O)=O)c1 InChI=1S/C32H38FNO5S/c1-29(2,3)22-8-9-25-21(19-22)7-10-26-32(25,40(38,39)24-6-4-5-23(33)20-24)17-18-34(26)27(35)30-11-14-31(15-12-30,16-13-30)28(36)37/h4-6,8-9,19-20,26H,7,10-18H2,1-3H3,(H,36,37) OKAADCSOQUCVGS-UHFFFAOYSA-N 382562 US10273259, Example 271::US10711020, Example 271 Nuclear receptor ROR-gamma Mus musculus 50.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382562&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679072 404851921 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765173 CC(C)(C)c1ccc2c(CCC3N(CCC23S(=O)(=O)c2cccc(F)c2)C(=O)C2CCS(=O)(=O)CC2)c1 InChI=1S/C28H34FNO5S2/c1-27(2,3)21-8-9-24-20(17-21)7-10-25-28(24,37(34,35)23-6-4-5-22(29)18-23)13-14-30(25)26(31)19-11-15-36(32,33)16-12-19/h4-6,8-9,17-19,25H,7,10-16H2,1-3H3 MPYDARFDYPFKMC-UHFFFAOYSA-N 382563 US10273259, Example 272::US10711020, Example 272 Nuclear receptor ROR-gamma Mus musculus 42.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382563&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679085 404851922 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765174 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? CXZPWDRHFGQVNB-VRSFHCCXSA-N 382564 US10273259, Example 273::US10273259, Example 278::US10711020, Example 278 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382564&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678710 404851923 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765175 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H31ClF7NO5S/c1-18-16-21(4-6-23(18)33)47(45,46)29-14-15-41(25(42)27-8-11-28(12-9-27,13-10-27)26(43)44)24(29)7-2-19-17-20(3-5-22(19)29)30(34,31(35,36)37)32(38,39)40/h3-6,16-17,24H,2,7-15H2,1H3,(H,43,44) XTTDRKVWPOUOJI-UHFFFAOYSA-N 382565 US10273259, Example 274::US10711020, Example 274 Nuclear receptor ROR-gamma Mus musculus 179 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382565&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678839 404851924 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765176 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO6S/c1-16-14-20(4-6-22(16)31)46(44,45)27-12-13-39(25(42)26(43)10-8-17(9-11-26)24(40)41)23(27)7-2-18-15-19(3-5-21(18)27)28(32,29(33,34)35)30(36,37)38/h3-6,14-15,17,23,43H,2,7-13H2,1H3,(H,40,41)/t17-,23?,26+,27? DRGNQJLXZGBYPJ-MTOUGUCQSA-N 382566 US10273259, Example 275::US10711020, Example 275 Nuclear receptor ROR-gamma Mus musculus 150 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382566&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678612 404851925 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765177 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C31H31ClF7NO5S/c1-17-15-21(5-7-23(17)32)46(44,45)28-13-14-40(26(43)27(2)11-9-18(10-12-27)25(41)42)24(28)8-3-19-16-20(4-6-22(19)28)29(33,30(34,35)36)31(37,38)39/h4-7,15-16,18,24H,3,8-14H2,1-2H3,(H,41,42)/t18-,24?,27-,28? CRUSBSVDMSHIJP-GLMFJJLTSA-N 382567 US10273259, Example 276::US10711020, Example 276 Nuclear receptor ROR-gamma Mus musculus 166 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382567&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678856 404851926 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765178 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C31H31ClF7NO5S/c1-17-15-21(5-7-23(17)32)46(44,45)28-13-14-40(25(41)18-9-11-27(2,12-10-18)26(42)43)24(28)8-3-19-16-20(4-6-22(19)28)29(33,30(34,35)36)31(37,38)39/h4-7,15-16,18,24H,3,8-14H2,1-2H3,(H,42,43)/t18-,24?,27-,28? OVEJXCRQIMBGPQ-GLMFJJLTSA-N 382568 US10273259, Example 277::US10711020, Example 277 Nuclear receptor ROR-gamma Mus musculus 68.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382568&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678717 404851927 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765179 Cc1cc(ccc1Cl)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29ClF7NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? CXZPWDRHFGQVNB-VRSFHCCXSA-N 382564 US10273259, Example 273::US10273259, Example 278::US10711020, Example 278 Nuclear receptor ROR-gamma Mus musculus 5561 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382564&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678710 404851923 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765180 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H31F8NO5S/c1-18-16-21(4-6-23(18)33)47(45,46)29-14-15-41(25(42)27-8-11-28(12-9-27,13-10-27)26(43)44)24(29)7-2-19-17-20(3-5-22(19)29)30(34,31(35,36)37)32(38,39)40/h3-6,16-17,24H,2,7-15H2,1H3,(H,43,44) SHMZBEASAIVZGQ-UHFFFAOYSA-N 382570 US10273259, Example 279::US10273259, Example 406::US10711020, Example 406 Nuclear receptor ROR-gamma Mus musculus 42.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382570&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679057 404851928 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765181 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28F9NO5S/c1-16-14-20(4-6-22(16)31)46(44,45)27-12-13-40(25(43)26(32)10-8-17(9-11-26)24(41)42)23(27)7-2-18-15-19(3-5-21(18)27)28(33,29(34,35)36)30(37,38)39/h3-6,14-15,17,23H,2,7-13H2,1H3,(H,41,42)/t17-,23?,26+,27? HMUIKTMNWCIRAR-MTOUGUCQSA-N 382571 US10273259, Example 280::US10711020, Example 407 Nuclear receptor ROR-gamma Mus musculus 52.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382571&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678841 404851929 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765182 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? HLPIMFURZPXHEZ-VRSFHCCXSA-N 382572 US10273259, Example 281 Nuclear receptor ROR-gamma Mus musculus 32.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382572&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678625 404851930 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765183 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-16-14-20(4-6-22(16)29)44(41,42)25-10-11-37(24(38)17-8-12-43(39,40)13-9-17)23(25)7-2-18-15-19(3-5-21(18)25)26(30,27(31,32)33)28(34,35)36/h3-6,14-15,17,23H,2,7-13H2,1H3 ZLKCPAJNBVGSGB-UHFFFAOYSA-N 382573 US10273259, Example 282::US10273259, Example 392::US10711020, Example 392 Nuclear receptor ROR-gamma Mus musculus 55.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382573&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678618 404851931 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765184 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC2(CC(C2)C(O)=O)C1 InChI=1S/C31H29F8NO5S/c1-16-10-21(4-6-23(16)32)46(44,45)28-8-9-40(25(41)18-12-27(13-18)14-19(15-27)26(42)43)24(28)7-2-17-11-20(3-5-22(17)28)29(33,30(34,35)36)31(37,38)39/h3-6,10-11,18-19,24H,2,7-9,12-15H2,1H3,(H,42,43) JSFTYTJBIXKDLT-UHFFFAOYSA-N 382574 US10273259, Example 283 Nuclear receptor ROR-gamma Mus musculus 33.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382574&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995601 404851932 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765185 CC(=O)N[C@H]1CC[C@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O4S/c1-17(41)39-22-8-2-18(3-9-22)26(42)40-15-14-27(45(43,44)23-10-6-21(31)7-11-23)24-12-5-20(16-19(24)4-13-25(27)40)28(32,29(33,34)35)30(36,37)38/h5-7,10-12,16,18,22,25H,2-4,8-9,13-15H2,1H3,(H,39,41)/t18-,22+,25-,27-/m1/s1 FCWDXBLPNWKWRH-XGHUSFQNSA-N 382575 US10273259, Example 284::US10711020, Example 284 Nuclear receptor ROR-gamma Mus musculus 51.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382575&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678543 404851933 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765186 CC(=O)N[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O4S/c1-17(41)39-22-8-2-18(3-9-22)26(42)40-15-14-27(45(43,44)23-10-6-21(31)7-11-23)24-12-5-20(16-19(24)4-13-25(27)40)28(32,29(33,34)35)30(36,37)38/h5-7,10-12,16,18,22,25H,2-4,8-9,13-15H2,1H3,(H,39,41)/t18-,22-,25-,27-/m1/s1 FCWDXBLPNWKWRH-ZDABEDDOSA-N 382576 US10273259, Example 285::US10711020, Example 285 Nuclear receptor ROR-gamma Mus musculus 46.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382576&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678543 404851934 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765187 CC(=O)NC12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H32F8N2O4S/c1-19(43)41-28-13-10-27(11-14-28,12-15-28)26(44)42-17-16-29(47(45,46)23-6-4-22(33)5-7-23)24-8-3-21(18-20(24)2-9-25(29)42)30(34,31(35,36)37)32(38,39)40/h3-8,18,25H,2,9-17H2,1H3,(H,41,43)/t25-,27?,28?,29-/m1/s1 CWZVPVLLTKPSAH-RFBOAJLRSA-N 382577 US10273259, Example 286::US10711020, Example 286 Nuclear receptor ROR-gamma Mus musculus 88.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382577&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678709 404851935 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765188 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C31H29F8NO5S/c32-21-3-1-4-22(12-21)46(44,45)28-9-2-10-40(25(41)18-13-27(14-18)15-19(16-27)26(42)43)24(28)8-5-17-11-20(6-7-23(17)28)29(33,30(34,35)36)31(37,38)39/h1,3-4,6-7,11-12,18-19,24H,2,5,8-10,13-16H2,(H,42,43) HEPPQSRFVKCCOU-UHFFFAOYSA-N 382578 US10273259, Example 287::US10711020, Example 287 Nuclear receptor ROR-gamma Mus musculus 40.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382578&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678864 404851936 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765189 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H29F8NO5S/c32-21-4-6-22(7-5-21)46(44,45)28-10-1-11-40(25(41)18-13-27(14-18)15-19(16-27)26(42)43)24(28)9-2-17-12-20(3-8-23(17)28)29(33,30(34,35)36)31(37,38)39/h3-8,12,18-19,24H,1-2,9-11,13-16H2,(H,42,43) UKJAMYVHOFCMAX-UHFFFAOYSA-N 382579 US10273259, Example 288::US10711020, Example 288 Nuclear receptor ROR-gamma Mus musculus 22.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382579&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678971 404851937 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765190 CC1CC(CCS1(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-16-14-18(10-13-43(16,39)40)24(38)37-12-11-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(15-17(22)2-9-23(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,15-16,18,23H,2,9-14H2,1H3/t16?,18?,23-,25-/m1/s1 IOIGWHJVXBSMDU-WCCBJSLHSA-N 382580 US10273259, Example 289::US10273259, Example 290::US10711020, Example 290 Nuclear receptor ROR-gamma Mus musculus 42.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382580&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995602 404851938 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765191 CC1CC(CCS1(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-16-14-18(10-13-43(16,39)40)24(38)37-12-11-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(15-17(22)2-9-23(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,15-16,18,23H,2,9-14H2,1H3/t16?,18?,23-,25-/m1/s1 IOIGWHJVXBSMDU-WCCBJSLHSA-N 382580 US10273259, Example 289::US10273259, Example 290::US10711020, Example 290 Nuclear receptor ROR-gamma Mus musculus 53.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382580&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995602 404851938 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765192 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(Cl)ccc21)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H29ClFNO5S/c29-19-5-6-22-18(16-19)4-7-23-28(22,37(35,36)21-3-1-2-20(30)17-21)14-15-31(23)24(32)26-8-11-27(12-9-26,13-10-26)25(33)34/h1-3,5-6,16-17,23H,4,7-15H2,(H,33,34) BSKKXSIZSHWHBM-UHFFFAOYSA-N 382582 US10273259, Example 291::US10711020, Example 291 Nuclear receptor ROR-gamma Mus musculus 237 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382582&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679079 404851939 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765193 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(Cl)ccc21)S(=O)(=O)c1cccc(F)c1 InChI=1S/C26H27ClFNO5S/c27-19-9-10-22-18(14-19)8-11-23-26(22,35(33,34)21-3-1-2-20(28)15-21)12-13-29(23)24(30)16-4-6-17(7-5-16)25(31)32/h1-3,9-10,14-17,23H,4-8,11-13H2,(H,31,32)/t16-,17-,23?,26? VRSSOVTVTCALKR-LRVXPCDCSA-N 382583 US10273259, Example 292::US10711020, Example 292 Nuclear receptor ROR-gamma Mus musculus 134 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382583&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678697 404851940 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765194 C[C@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-16-15-37(24(38)17-10-12-43(39,40)13-11-17)23-9-2-18-14-19(26(30,27(31,32)33)28(34,35)36)3-8-22(18)25(16,23)44(41,42)21-6-4-20(29)5-7-21/h3-8,14,16-17,23H,2,9-13,15H2,1H3/t16-,23?,25?/m0/s1 PDDCPKPORGRAHB-MQHNZPCDSA-N 382584 US10273259, Example 293::US10711020, Example 293 Nuclear receptor ROR-gamma Mus musculus 160 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382584&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678611 404851941 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765195 C[C@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-15-39(25(40)17-2-4-18(5-3-17)26(41)42)24-13-6-19-14-20(28(32,29(33,34)35)30(36,37)38)7-12-23(19)27(16,24)45(43,44)22-10-8-21(31)9-11-22/h7-12,14,16-18,24H,2-6,13,15H2,1H3,(H,41,42)/t16-,17-,18-,24?,27?/m0/s1 INLCDNRAIIGCBA-KGGGPQMJSA-N 382585 US10273259, Example 294::US10711020, Example 294 Nuclear receptor ROR-gamma Mus musculus 125 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382585&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678621 404851942 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765196 C[C@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)C1CCS(=O)(=O)CC1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-16-15-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(26(30,27(31,32)33)28(34,35)36)14-18(22)2-9-23(25)37(16)24(38)17-10-12-43(39,40)13-11-17/h3-8,14,16-17,23H,2,9-13,15H2,1H3/t16-,23?,25?/m0/s1 IXIYUCDUDFGTPU-MQHNZPCDSA-N 382586 US10273259, Example 295::US10711020, Example 295 Nuclear receptor ROR-gamma Mus musculus 205 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382586&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679082 404851943 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765197 C[C@@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-16-15-37(24(38)17-10-12-43(39,40)13-11-17)23-9-2-18-14-19(26(30,27(31,32)33)28(34,35)36)3-8-22(18)25(16,23)44(41,42)21-6-4-20(29)5-7-21/h3-8,14,16-17,23H,2,9-13,15H2,1H3/t16-,23?,25?/m1/s1 PDDCPKPORGRAHB-UOMYTMTESA-N 382587 US10273259, Example 296::US10711020, Example 296 Nuclear receptor ROR-gamma Mus musculus 55.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382587&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678514 404851944 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765198 C[C@@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)C1CCS(=O)(=O)CC1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S2/c1-16-15-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(26(30,27(31,32)33)28(34,35)36)14-18(22)2-9-23(25)37(16)24(38)17-10-12-43(39,40)13-11-17/h3-8,14,16-17,23H,2,9-13,15H2,1H3/t16-,23?,25?/m1/s1 IXIYUCDUDFGTPU-UOMYTMTESA-N 382588 US10273259, Example 297::US10711020, Example 297 Nuclear receptor ROR-gamma Mus musculus 43.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382588&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678457 404851945 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765199 C[C@@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-15-39(25(40)17-2-4-18(5-3-17)26(41)42)24-13-6-19-14-20(28(32,29(33,34)35)30(36,37)38)7-12-23(19)27(16,24)45(43,44)22-10-8-21(31)9-11-22/h7-12,14,16-18,24H,2-6,13,15H2,1H3,(H,41,42)/t16-,17-,18-,24?,27?/m1/s1 INLCDNRAIIGCBA-NTUALMSUSA-N 382589 US10273259, Example 298::US10711020, Example 298 Nuclear receptor ROR-gamma Mus musculus 49.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382589&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679098 404851946 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765200 C[C@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)[C@H]1CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-15-27(45(43,44)22-10-8-21(31)9-11-22)23-12-7-20(28(32,29(33,34)35)30(36,37)38)14-19(23)6-13-24(27)39(16)25(40)17-2-4-18(5-3-17)26(41)42/h7-12,14,16-18,24H,2-6,13,15H2,1H3,(H,41,42)/t16-,17-,18-,24?,27?/m0/s1 NLAWXJFYNVXSGK-KGGGPQMJSA-N 382590 US10273259, Example 299::US10711020, Example 299 Nuclear receptor ROR-gamma Mus musculus 47.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382590&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678410 404851947 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765201 OC(=O)CN1[C@@H](CCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F8N2O6S/c29-17-3-5-18(6-4-17)45(43,44)25-11-12-37(24(42)20-8-10-22(39)38(20)14-23(40)41)21(25)9-1-15-13-16(2-7-19(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,13,20-21H,1,8-12,14H2,(H,40,41)/t20-,21+,25+/m0/s1 RMJOQNJGTTYNCO-BPYKYCOYSA-N 382591 US10273259, Example 300::US10711020, Example 300 Nuclear receptor ROR-gamma Mus musculus 19.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382591&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678718 404851948 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765202 C[C@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)C1(O)CCS(=O)(=O)CC1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO6S2/c1-16-15-25(45(42,43)20-6-4-19(29)5-7-20)21-8-3-18(26(30,27(31,32)33)28(34,35)36)14-17(21)2-9-22(25)37(16)23(38)24(39)10-12-44(40,41)13-11-24/h3-8,14,16,22,39H,2,9-13,15H2,1H3/t16-,22?,25?/m0/s1 AUVKXICOJLQARP-FPXRNPNWSA-N 382592 US10273259, Example 301::US10711020, Example 301 Nuclear receptor ROR-gamma Mus musculus 89.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382592&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678840 404851949 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765203 C[C@H]1CC2(C(CCc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)N1C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F9NO5S/c1-16-15-27(46(44,45)21-6-4-20(31)5-7-21)22-8-3-19(28(33,29(34,35)36)30(37,38)39)14-18(22)2-9-23(27)40(16)25(43)26(32)12-10-17(11-13-26)24(41)42/h3-8,14,16-17,23H,2,9-13,15H2,1H3,(H,41,42)/t16-,17-,23?,26+,27?/m0/s1 DKGOXSGVARKBRJ-JYPCXJDLSA-N 382593 US10273259, Example 302::US10711020, Example 302 Nuclear receptor ROR-gamma Mus musculus 154 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382593&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678630 404851950 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765204 C[C@H]1CN(C2CCc3cc(ccc3C12S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28F9NO5S/c1-16-15-40(25(43)26(32)12-10-17(11-13-26)24(41)42)23-9-2-18-14-19(28(33,29(34,35)36)30(37,38)39)3-8-22(18)27(16,23)46(44,45)21-6-4-20(31)5-7-21/h3-8,14,16-17,23H,2,9-13,15H2,1H3,(H,41,42)/t16-,17-,23?,26+,27?/m0/s1 PCCONJHZMXEANB-JYPCXJDLSA-N 382594 US10273259, Example 303::US10711020, Example 303 Nuclear receptor ROR-gamma Mus musculus 38.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382594&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678977 404851951 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765205 OC(=O)[C@@H]1CCC(=O)N1CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F8N2O6S/c29-17-3-5-18(6-4-17)45(43,44)25-11-12-37(23(40)14-38-20(24(41)42)8-10-22(38)39)21(25)9-1-15-13-16(2-7-19(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,13,20-21H,1,8-12,14H2,(H,41,42)/t20-,21+,25+/m0/s1 QEWNJCVCXUYNBH-BPYKYCOYSA-N 382595 US10273259, Example 304::US10711020, Example 304 Nuclear receptor ROR-gamma Mus musculus 75.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382595&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678884 404851952 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765206 CC1(C)OCC(C)(CO1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8NO5S/c1-24(2)42-15-25(3,16-43-24)23(39)38-13-12-26(44(40,41)20-8-6-19(30)7-9-20)21-10-5-18(14-17(21)4-11-22(26)38)27(31,28(32,33)34)29(35,36)37/h5-10,14,22H,4,11-13,15-16H2,1-3H3/t22-,26-/m1/s1 BDXQIXFFUBQGIT-ATIYNZHBSA-N 382596 US10273259, Example 305::US10711020, Example 305 Nuclear receptor ROR-gamma Mus musculus 66.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382596&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669231 404851953 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765207 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H29F8NO5S/c31-21-3-1-4-22(16-21)45(43,44)27-13-2-14-39(25(40)17-5-7-18(8-6-17)26(41)42)24(27)12-9-19-15-20(10-11-23(19)27)28(32,29(33,34)35)30(36,37)38/h1,3-4,10-11,15-18,24H,2,5-9,12-14H2,(H,41,42)/t17-,18-,24?,27? FLCUOBVSOPIEMY-VRSFHCCXSA-N 382597 US10273259, Example 306::US10711020, Example 306 Nuclear receptor ROR-gamma Mus musculus 31.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382597&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678978 404851954 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765208 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C32H31F8NO5S/c33-21-3-1-4-22(18-21)47(45,46)29-9-2-16-41(25(42)27-10-13-28(14-11-27,15-12-27)26(43)44)24(29)8-5-19-17-20(6-7-23(19)29)30(34,31(35,36)37)32(38,39)40/h1,3-4,6-7,17-18,24H,2,5,8-16H2,(H,43,44) LQNFAKZLTXMKMT-UHFFFAOYSA-N 382598 US10273259, Example 307::US10711020, Example 307 Nuclear receptor ROR-gamma Mus musculus 35.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382598&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678525 404851955 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765209 Fc1cccc(c1)S(=O)(=O)C12CCCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c29-20-3-1-4-21(16-20)44(41,42)25-11-2-12-37(24(38)17-9-13-43(39,40)14-10-17)23(25)8-5-18-15-19(6-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h1,3-4,6-7,15-17,23H,2,5,8-14H2 NIVPOSHCFNLVCO-UHFFFAOYSA-N 382599 US10273259, Example 308::US10711020, Example 308 Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382599&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678885 404851956 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765210 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C31H31F8NO5S/c1-27(13-10-18(11-14-27)25(41)42)26(43)40-15-3-12-28(46(44,45)22-5-2-4-21(32)17-22)23-8-7-20(16-19(23)6-9-24(28)40)29(33,30(34,35)36)31(37,38)39/h2,4-5,7-8,16-18,24H,3,6,9-15H2,1H3,(H,41,42)/t18-,24?,27-,28? KNSUHCRQKJESPE-GLMFJJLTSA-N 382600 US10273259, Example 309::US10711020, Example 309 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382600&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678518 404851957 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765211 Fc1ccc(cc1)S(=O)(=O)C12CCCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c29-20-4-6-21(7-5-20)44(41,42)25-12-1-13-37(24(38)17-10-14-43(39,40)15-11-17)23(25)9-2-18-16-19(3-8-22(18)25)26(30,27(31,32)33)28(34,35)36/h3-8,16-17,23H,1-2,9-15H2 ILUFATUAWRPTIE-UHFFFAOYSA-N 382601 US10273259, Example 310::US10711020, Example 310 Nuclear receptor ROR-gamma Mus musculus 184 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382601&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678725 404851958 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765212 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H31F8NO5S/c33-21-4-6-22(7-5-21)47(45,46)29-10-1-17-41(25(42)27-11-14-28(15-12-27,16-13-27)26(43)44)24(29)9-2-19-18-20(3-8-23(19)29)30(34,31(35,36)37)32(38,39)40/h3-8,18,24H,1-2,9-17H2,(H,43,44) IISZWODINTVQOP-UHFFFAOYSA-N 382602 US10273259, Example 311::US10711020, Example 311 Nuclear receptor ROR-gamma Mus musculus 37.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382602&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679095 404851959 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765213 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C30H30F7NO5S/c31-28(29(32,33)34,30(35,36)37)21-12-13-23-20(17-21)11-14-24-27(23,44(42,43)22-5-2-1-3-6-22)15-4-16-38(24)25(39)18-7-9-19(10-8-18)26(40)41/h1-3,5-6,12-13,17-19,24H,4,7-11,14-16H2,(H,40,41)/t18-,19-,24?,27? WTYIAQZPHNCSLJ-QXIWJBPRSA-N 382603 US10273259, Example 312::US10711020, Example 312 Nuclear receptor ROR-gamma Mus musculus 68.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382603&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678875 404851960 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765214 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C32H32F7NO5S/c33-30(31(34,35)36,32(37,38)39)21-8-9-23-20(19-21)7-10-24-29(23,46(44,45)22-5-2-1-3-6-22)11-4-18-40(24)25(41)27-12-15-28(16-13-27,17-14-27)26(42)43/h1-3,5-6,8-9,19,24H,4,7,10-18H2,(H,42,43) VINXYLSNORSEJE-UHFFFAOYSA-N 382604 US10273259, Example 313::US10711020, Example 313 Nuclear receptor ROR-gamma Mus musculus 32.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382604&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678506 404851961 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765215 C[C@@]1(CC[C@@H](CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(O)=O InChI=1S/C31H32F7NO5S/c1-27(26(41)42)15-12-19(13-16-27)25(40)39-17-5-14-28(45(43,44)22-6-3-2-4-7-22)23-10-9-21(18-20(23)8-11-24(28)39)29(32,30(33,34)35)31(36,37)38/h2-4,6-7,9-10,18-19,24H,5,8,11-17H2,1H3,(H,41,42)/t19-,24?,27-,28? FROWNVDAEYRDAL-XJNMGFQWSA-N 382605 US10273259, Example 314::US10711020, Example 314 Nuclear receptor ROR-gamma Mus musculus 99.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382605&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678528 404851962 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765216 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H21F8NO5S/c30-20-2-1-3-21(15-20)44(42,43)26-12-13-38(24(39)16-4-6-17(7-5-16)25(40)41)23(26)11-8-18-14-19(9-10-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-7,9-10,14-15,23H,8,11-13H2,(H,40,41) FFEDCEHLNOSYJO-UHFFFAOYSA-N 382606 US10273259, Example 315::US10711020, Example 315 Nuclear receptor ROR-gamma Mus musculus 97.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382606&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679083 404851963 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765217 OC(=O)Cc1ccc(CC(=O)N2CCC3(C2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2cccc(F)c2)cc1 InChI=1S/C31H25F8NO5S/c32-22-2-1-3-23(17-22)46(44,45)28-12-13-40(26(41)14-18-4-6-19(7-5-18)15-27(42)43)25(28)11-8-20-16-21(9-10-24(20)28)29(33,30(34,35)36)31(37,38)39/h1-7,9-10,16-17,25H,8,11-15H2,(H,42,43) DPJNUSSDKWBHOF-UHFFFAOYSA-N 382607 US10273259, Example 316::US10711020, Example 316 Nuclear receptor ROR-gamma Mus musculus 103 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382607&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678631 404851964 C03768 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765218 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccc(cc1)C#N InChI=1S/C30H22F8N2O3S/c31-22-2-1-3-23(16-22)44(42,43)27-12-13-40(26(41)14-18-4-6-19(17-39)7-5-18)25(27)11-8-20-15-21(9-10-24(20)27)28(32,29(33,34)35)30(36,37)38/h1-7,9-10,15-16,25H,8,11-14H2 JEPADORYZCYPTI-UHFFFAOYSA-N 382608 US10273259, Example 317::US10711020, Example 317 Nuclear receptor ROR-gamma Mus musculus 336 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382608&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678623 404851965 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765219 OC(=O)C1CCC(C1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H25F8NO5S/c29-19-2-1-3-20(14-19)43(41,42)25-10-11-37(23(38)16-4-5-17(12-16)24(39)40)22(25)9-6-15-13-18(7-8-21(15)25)26(30,27(31,32)33)28(34,35)36/h1-3,7-8,13-14,16-17,22H,4-6,9-12H2,(H,39,40) WBLHKOGHJJCBTF-UHFFFAOYSA-N 382609 US10273259, Example 318::US10711020, Example 318 Nuclear receptor ROR-gamma Mus musculus 111 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382609&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678627 404851966 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765220 OC(=O)c1cccc(CC(=O)N2CCC3(C2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2cccc(F)c2)c1 InChI=1S/C30H23F8NO5S/c31-21-5-2-6-22(16-21)45(43,44)27-11-12-39(25(40)14-17-3-1-4-19(13-17)26(41)42)24(27)10-7-18-15-20(8-9-23(18)27)28(32,29(33,34)35)30(36,37)38/h1-6,8-9,13,15-16,24H,7,10-12,14H2,(H,41,42) MMOQILWYIZMKNT-UHFFFAOYSA-N 382610 US10273259, Example 319::US10711020, Example 319 Nuclear receptor ROR-gamma Mus musculus 78.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382610&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679114 404851967 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765221 OC(=O)c1cncc(CC(=O)N2CCC3(C2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2cccc(F)c2)c1 InChI=1S/C29H22F8N2O5S/c30-20-2-1-3-21(13-20)45(43,44)26-8-9-39(24(40)11-16-10-18(25(41)42)15-38-14-16)23(26)7-4-17-12-19(5-6-22(17)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-6,10,12-15,23H,4,7-9,11H2,(H,41,42) QNRDHNGPUHQURA-UHFFFAOYSA-N 382611 US10273259, Example 320::US10711020, Example 320 Nuclear receptor ROR-gamma Mus musculus 333 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382611&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679117 404851968 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765222 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H27F8NO5S/c31-20-2-1-3-21(11-20)45(43,44)27-8-9-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)7-4-16-10-19(5-6-22(16)27)28(32,29(33,34)35)30(36,37)38/h1-3,5-6,10-11,17-18,23H,4,7-9,12-15H2,(H,41,42) KYPLGCNUBPIZLF-UHFFFAOYSA-N 382612 US10273259, Example 321 Nuclear receptor ROR-gamma Mus musculus 81.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382612&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678540 404851969 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765223 OC(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H21F8NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,23H,5,12-14H2,(H,40,41)/t23-,26-/m1/s1 ZKAXALRFUNLGET-ZEQKJWHPSA-N 382613 US10273259, Example 322::US10711020, Example 322 Nuclear receptor ROR-gamma Mus musculus 74.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382613&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679105 404851970 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765224 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382614 US10273259, Example 323::US10711020, Example 323 Nuclear receptor ROR-gamma Mus musculus 125 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382614&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678527 404851971 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765225 OC(=O)c1cnc(cn1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H19F8N3O5S/c28-16-2-1-3-17(11-16)44(42,43)24-8-9-38(22(39)19-12-37-20(13-36-19)23(40)41)21(24)7-4-14-10-15(5-6-18(14)24)25(29,26(30,31)32)27(33,34)35/h1-3,5-6,10-13,21H,4,7-9H2,(H,40,41) FDAQVIWZIHQLPI-UHFFFAOYSA-N 382615 US10273259, Example 324::US10711020, Example 324 Nuclear receptor ROR-gamma Mus musculus 128 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382615&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678505 404851972 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765226 Cc1cc(cc(c1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(O)=O InChI=1S/C30H23F8NO5S/c1-16-11-18(13-19(12-16)26(41)42)25(40)39-10-9-27(45(43,44)22-4-2-3-21(31)15-22)23-7-6-20(14-17(23)5-8-24(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,6-7,11-15,24H,5,8-10H2,1H3,(H,41,42) DWXDIERSXAHUBC-UHFFFAOYSA-N 382616 US10273259, Example 325::US10711020, Example 325 Nuclear receptor ROR-gamma Mus musculus 152 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382616&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679093 404851973 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765227 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42)/t17?,18?,23-,26?,27-/m1/s1 UPWOYPBEIAJQBZ-CRDIYBEASA-N 382617 US10273259, Example 326::US10711020, Example 358 Nuclear receptor ROR-gamma Mus musculus 128 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382617&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678649 404851974 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765228 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)-c1nnco1 InChI=1S/C30H21F8N3O4S/c31-21-7-9-22(10-8-21)46(43,44)27-13-14-41(26(42)18-3-1-17(2-4-18)25-40-39-16-45-25)24(27)12-5-19-15-20(6-11-23(19)27)28(32,29(33,34)35)30(36,37)38/h1-4,6-11,15-16,24H,5,12-14H2/t24-,27-/m1/s1 HVZIZFONULYDJA-SHQCIBLASA-N 382618 US10273259, Example 327::US10711020, Example 327 Nuclear receptor ROR-gamma Mus musculus 82.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382618&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678734 404851975 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765229 OCc1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H23F8NO4S/c30-21-7-9-22(10-8-21)43(41,42)26-13-14-38(25(40)18-3-1-17(16-39)2-4-18)24(26)12-5-19-15-20(6-11-23(19)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,24,39H,5,12-14,16H2/t24-,26-/m1/s1 XLQOBXBSKGJKGF-AOYPEHQESA-N 382619 US10273259, Example 328::US10711020, Example 328 Nuclear receptor ROR-gamma Mus musculus 54.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382619&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678633 404851976 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765230 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)-c1nn[nH]n1 382620 US10273259, Example 329::US10711020, Example 329 Nuclear receptor ROR-gamma Mus musculus 62.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382620&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678695 404851977 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765231 NS(=O)(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O5S2/c29-19-5-9-20(10-6-19)44(40,41)25-13-14-38(24(39)16-1-7-21(8-2-16)45(37,42)43)23(25)12-3-17-15-18(4-11-22(17)25)26(30,27(31,32)33)28(34,35)36/h1-2,4-11,15,23H,3,12-14H2,(H2,37,42,43)/t23-,25-/m1/s1 WMCHBRMNHFQGED-ILBGXUMGSA-N 382621 US10273259, Example 330::US10711020, Example 330 Nuclear receptor ROR-gamma Mus musculus 115 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382621&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679102 404851978 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765232 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccncc1 InChI=1S/C28H22F8N2O3S/c29-20-3-5-21(6-4-20)42(40,41)25-11-14-38(24(39)15-17-9-12-37-13-10-17)23(25)8-1-18-16-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,9-10,12-13,16,23H,1,8,11,14-15H2/t23-,25-/m1/s1 SEDSNSRRZRDDNP-ILBGXUMGSA-N 382622 US10273259, Example 331::US10711020, Example 331 Nuclear receptor ROR-gamma Mus musculus 54.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382622&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679108 404851979 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765233 OC(=O)c1ccc(cc1)S(=O)(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H21F8NO6S2/c29-19-5-9-20(10-6-19)44(40,41)25-13-14-37(45(42,43)21-7-1-16(2-8-21)24(38)39)23(25)12-3-17-15-18(4-11-22(17)25)26(30,27(31,32)33)28(34,35)36/h1-2,4-11,15,23H,3,12-14H2,(H,38,39)/t23-,25-/m1/s1 SEXUZVDOMNAALM-ILBGXUMGSA-N 382623 US10273259, Example 332::US10711020, Example 332 Nuclear receptor ROR-gamma Mus musculus 121 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382623&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678868 404851980 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765234 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1cncnc1 InChI=1S/C27H21F8N3O3S/c28-19-3-5-20(6-4-19)42(40,41)24-9-10-38(23(39)11-16-13-36-15-37-14-16)22(24)8-1-17-12-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,12-15,22H,1,8-11H2/t22-,24-/m1/s1 LEKQDPRYEBJVIH-ISKFKSNPSA-N 382624 US10273259, Example 333::US10711020, Example 333 Nuclear receptor ROR-gamma Mus musculus 88.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382624&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678845 404851981 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765235 NS(=O)(=O)c1cc(ccc1Cl)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H21ClF8N2O5S2/c29-21-9-1-16(14-22(21)46(38,43)44)24(40)39-12-11-25(45(41,42)19-6-4-18(30)5-7-19)20-8-3-17(13-15(20)2-10-23(25)39)26(31,27(32,33)34)28(35,36)37/h1,3-9,13-14,23H,2,10-12H2,(H2,38,43,44)/t23-,25-/m1/s1 RPNHVVAALQLNOB-ILBGXUMGSA-N 382625 US10273259, Example 334::US10711020, Example 334 Nuclear receptor ROR-gamma Mus musculus 41.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382625&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678821 404851982 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765236 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2C(=O)NCc2c1 InChI=1S/C30H22F8N2O4S/c31-20-4-6-21(7-5-20)45(43,44)27-11-12-40(26(42)17-1-8-22-18(13-17)15-39-25(22)41)24(27)10-2-16-14-19(3-9-23(16)27)28(32,29(33,34)35)30(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,39,41)/t24-,27-/m1/s1 UBTUPRGYKVUASL-SHQCIBLASA-N 382626 US10273259, Example 335::US10711020, Example 335 Nuclear receptor ROR-gamma Mus musculus 140 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382626&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678603 404851983 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765237 NS(=O)(=O)c1cccc(c1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O5S2/c29-19-6-8-20(9-7-19)44(40,41)25-12-13-38(24(39)17-2-1-3-21(15-17)45(37,42)43)23(25)11-4-16-14-18(5-10-22(16)25)26(30,27(31,32)33)28(34,35)36/h1-3,5-10,14-15,23H,4,11-13H2,(H2,37,42,43)/t23-,25-/m1/s1 NWFBAZUHPGTJHC-ILBGXUMGSA-N 382627 US10273259, Example 336::US10711020, Example 336 Nuclear receptor ROR-gamma Mus musculus 119 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382627&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678626 404851984 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765238 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2NC(=O)Cc2c1 InChI=1S/C30H22F8N2O4S/c31-20-4-6-21(7-5-20)45(43,44)27-11-12-40(26(42)17-1-9-23-18(13-17)15-25(41)39-23)24(27)10-2-16-14-19(3-8-22(16)27)28(32,29(33,34)35)30(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,39,41)/t24-,27-/m1/s1 HVAGBVYVAFXHLT-SHQCIBLASA-N 382628 US10273259, Example 337::US10711020, Example 337 Nuclear receptor ROR-gamma Mus musculus 186 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382628&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678993 404851985 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765239 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2[nH]cnc2c1 382629 US10273259, Example 338::US10711020, Example 338 Nuclear receptor ROR-gamma Mus musculus 239 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382629&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678728 404851986 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765240 OC(=O)c1cc(cc(c1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H21F8NO7S/c31-20-3-5-21(6-4-20)47(45,46)27-9-10-39(24(40)16-11-17(25(41)42)13-18(12-16)26(43)44)23(27)8-1-15-14-19(2-7-22(15)27)28(32,29(33,34)35)30(36,37)38/h2-7,11-14,23H,1,8-10H2,(H,41,42)(H,43,44)/t23-,27-/m1/s1 KENMFEAXPXMJJS-YIXXDRMTSA-N 382630 US10273259, Example 339::US10711020, Example 339 Nuclear receptor ROR-gamma Mus musculus 197 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382630&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678732 404851987 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765241 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2NC(=O)COc2c1 InChI=1S/C30H22F8N2O5S/c31-19-4-6-20(7-5-19)46(43,44)27-11-12-40(26(42)17-1-9-22-23(14-17)45-15-25(41)39-22)24(27)10-2-16-13-18(3-8-21(16)27)28(32,29(33,34)35)30(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,39,41)/t24-,27-/m1/s1 PNAROIQEGCCOSJ-SHQCIBLASA-N 382631 US10273259, Example 340::US10711020, Example 340 Nuclear receptor ROR-gamma Mus musculus 37.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382631&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679125 404851988 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765242 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C30H28F7NO5S/c31-28(29(32,33)34,30(35,36)37)20-7-8-22-17(12-20)6-9-23-27(22,44(42,43)21-4-2-1-3-5-21)10-11-38(23)24(39)18-13-26(14-18)15-19(16-26)25(40)41/h1-5,7-8,12,18-19,23H,6,9-11,13-16H2,(H,40,41)/t18?,19?,23-,26?,27-/m1/s1 WOJBGBRWZMNGRI-YTJHPHSKSA-N 382632 US10273259, Example 341 Nuclear receptor ROR-gamma Mus musculus 44.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382632&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678519 404851989 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765243 OC(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H22F7NO5S/c30-27(28(31,32)33,29(34,35)36)20-11-12-22-19(16-20)10-13-23-26(22,43(41,42)21-4-2-1-3-5-21)14-15-37(23)24(38)17-6-8-18(9-7-17)25(39)40/h1-9,11-12,16,23H,10,13-15H2,(H,39,40)/t23-,26-/m1/s1 USKRCYFWVMZWRP-ZEQKJWHPSA-N 382633 US10273259, Example 342::US10711020, Example 342 Nuclear receptor ROR-gamma Mus musculus 119 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382633&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678999 404851990 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765244 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2c(c1)C(=O)NS2(=O)=O InChI=1S/C29H20F8N2O6S2/c30-18-4-6-19(7-5-18)46(42,43)26-11-12-39(25(41)16-1-9-22-20(14-16)24(40)38-47(22,44)45)23(26)10-2-15-13-17(3-8-21(15)26)27(31,28(32,33)34)29(35,36)37/h1,3-9,13-14,23H,2,10-12H2,(H,38,40)/t23-,26-/m1/s1 YOVDSGAMTHRXTK-ZEQKJWHPSA-N 382634 US10273259, Example 343::US10711020, Example 343 Nuclear receptor ROR-gamma Mus musculus 106 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382634&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678863 404851991 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765245 OC(=O)c1cc(Cl)c(cc1Cl)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H19Cl2F8NO5S/c30-21-13-19(25(42)43)22(31)12-18(21)24(41)40-10-9-26(46(44,45)17-5-3-16(32)4-6-17)20-7-2-15(11-14(20)1-8-23(26)40)27(33,28(34,35)36)29(37,38)39/h2-7,11-13,23H,1,8-10H2,(H,42,43)/t23-,26-/m1/s1 FXAFXCOGEVHGHY-ZEQKJWHPSA-N 382635 US10273259, Example 344::US10711020, Example 344 Nuclear receptor ROR-gamma Mus musculus 10.00 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382635&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678982 404851992 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765246 NC(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H22F8N2O4S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-39(25(41)17-3-1-16(2-4-17)24(38)40)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,23H,5,12-14H2,(H2,38,40)/t23-,26-/m1/s1 LQUHSHQSUFRMIQ-ZEQKJWHPSA-N 382636 US10273259, Example 345::US10711020, Example 345 Nuclear receptor ROR-gamma Mus musculus 22.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382636&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679112 404851993 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765247 NC(=O)c1ccc(C(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c(F)c1 InChI=1S/C29H21F9N2O4S/c30-18-4-6-19(7-5-18)45(43,44)26-11-12-40(25(42)20-8-1-16(24(39)41)14-22(20)31)23(26)10-2-15-13-17(3-9-21(15)26)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,23H,2,10-12H2,(H2,39,41)/t23-,26-/m1/s1 MDWYXKVEAFUDBW-ZEQKJWHPSA-N 382637 US10273259, Example 346::US10711020, Example 346 Nuclear receptor ROR-gamma Mus musculus 78.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382637&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678729 404851994 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765248 OC(=O)C1CCCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c30-20-6-8-21(9-7-20)44(42,43)26-12-13-38(24(39)17-2-1-3-18(14-17)25(40)41)23(26)11-4-16-15-19(5-10-22(16)26)27(31,28(32,33)34)29(35,36)37/h5-10,15,17-18,23H,1-4,11-14H2,(H,40,41)/t17?,18?,23-,26-/m1/s1 FWTGORCOGNNJLR-OYUWVLQBSA-N 382638 US10273259, Example 347::US10273259, Example 348::US10711020, Example 348 Nuclear receptor ROR-gamma Mus musculus 5.00 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382638&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123319 404851995 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765249 OC(=O)C1CCCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c30-20-6-8-21(9-7-20)44(42,43)26-12-13-38(24(39)17-2-1-3-18(14-17)25(40)41)23(26)11-4-16-15-19(5-10-22(16)26)27(31,28(32,33)34)29(35,36)37/h5-10,15,17-18,23H,1-4,11-14H2,(H,40,41)/t17?,18?,23-,26-/m1/s1 FWTGORCOGNNJLR-OYUWVLQBSA-N 382638 US10273259, Example 347::US10273259, Example 348::US10711020, Example 348 Nuclear receptor ROR-gamma Mus musculus 34.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382638&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123319 404851995 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765250 OC(=O)c1cc(O)c(cc1O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H21F8NO7S/c30-16-3-5-17(6-4-16)46(44,45)26-9-10-38(24(41)18-12-22(40)19(25(42)43)13-21(18)39)23(26)8-1-14-11-15(2-7-20(14)26)27(31,28(32,33)34)29(35,36)37/h2-7,11-13,23,39-40H,1,8-10H2,(H,42,43)/t23-,26-/m1/s1 MXEIMENGTNBDPI-ZEQKJWHPSA-N 382640 US10273259, Example 349::US10711020, Example 349 Nuclear receptor ROR-gamma Mus musculus 601 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382640&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679115 404851996 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765251 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCCCC1 InChI=1S/C28H27F8NO3S/c29-20-8-10-21(11-9-20)41(39,40)25-14-15-37(24(38)17-4-2-1-3-5-17)23(25)13-6-18-16-19(7-12-22(18)25)26(30,27(31,32)33)28(34,35)36/h7-12,16-17,23H,1-6,13-15H2/t23-,25-/m1/s1 JAQLPAODRGTVQT-ILBGXUMGSA-N 382641 US10273259, Example 350::US10711020, Example 350 Nuclear receptor ROR-gamma Mus musculus 240 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382641&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678913 404851997 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765252 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccccc1 InChI=1S/C28H21F8NO3S/c29-20-8-10-21(11-9-20)41(39,40)25-14-15-37(24(38)17-4-2-1-3-5-17)23(25)13-6-18-16-19(7-12-22(18)25)26(30,27(31,32)33)28(34,35)36/h1-5,7-12,16,23H,6,13-15H2/t23-,25-/m1/s1 JVLYDNYXTISUKO-ILBGXUMGSA-N 382642 US10273259, Example 351::US10711020, Example 351 Nuclear receptor ROR-gamma Mus musculus 85.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382642&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678628 404851998 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765253 NC(=O)c1cccc(c1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H22F8N2O4S/c30-20-6-8-21(9-7-20)44(42,43)26-12-13-39(25(41)18-3-1-2-17(14-18)24(38)40)23(26)11-4-16-15-19(5-10-22(16)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-10,14-15,23H,4,11-13H2,(H2,38,40)/t23-,26-/m1/s1 MOZRISUTSMGOOS-ZEQKJWHPSA-N 382643 US10273259, Example 352::US10711020, Example 352 Nuclear receptor ROR-gamma Mus musculus 96.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382643&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678719 404851999 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765254 Cn1ccc(cc1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O4S/c1-37-12-10-17(15-23(37)39)24(40)38-13-11-25(43(41,42)20-6-4-19(29)5-7-20)21-8-3-18(14-16(21)2-9-22(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,10,12,14-15,22H,2,9,11,13H2,1H3/t22-,25-/m1/s1 SIVXBFINULJZLY-RCZVLFRGSA-N 382644 US10273259, Example 353::US10711020, Example 353 Nuclear receptor ROR-gamma Mus musculus 953 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382644&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679118 404852000 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765255 Cn1cc(ccc1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O4S/c1-37-15-17(3-11-23(37)39)24(40)38-13-12-25(43(41,42)20-7-5-19(29)6-8-20)21-9-4-18(14-16(21)2-10-22(25)38)26(30,27(31,32)33)28(34,35)36/h3-9,11,14-15,22H,2,10,12-13H2,1H3/t22-,25-/m1/s1 OVTLIBRJQHFICL-RCZVLFRGSA-N 382645 US10273259, Example 354::US10711020, Example 354 Nuclear receptor ROR-gamma Mus musculus 230 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382645&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678500 404852001 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765256 O[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO4S/c29-19-5-9-21(10-6-19)42(40,41)25-13-14-37(24(39)16-1-7-20(38)8-2-16)23(25)12-3-17-15-18(4-11-22(17)25)26(30,27(31,32)33)28(34,35)36/h4-6,9-11,15-16,20,23,38H,1-3,7-8,12-14H2/t16-,20-,23-,25-/m1/s1 CZOAKRDFNBPBNH-STHMRSITSA-N 382646 US10273259, Example 355::US10711020, Example 355 Nuclear receptor ROR-gamma Mus musculus 285 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382646&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678619 404852002 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765257 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC2(CC1)NC(=O)NC2=O InChI=1S/C30H27F8N3O5S/c31-19-3-5-20(6-4-19)47(45,46)27-13-14-41(23(42)16-9-11-26(12-10-16)24(43)39-25(44)40-26)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15-16,22H,1,8-14H2,(H2,39,40,43,44)/t16?,22-,26?,27-/m1/s1 SBVRHUOLSBTQLX-UHFDNVQUSA-N 382647 US10273259, Example 356 Nuclear receptor ROR-gamma Mus musculus 266 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382647&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679009 404852003 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765258 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42)/t17?,18?,23-,26?,27-/m1/s1 UPWOYPBEIAJQBZ-CRDIYBEASA-N 382648 US10273259, Example 357 Nuclear receptor ROR-gamma Mus musculus 104 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382648&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678649 404852004 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765259 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-20-3-5-21(6-4-20)45(43,44)27-9-10-39(24(40)17-12-26(13-17)14-18(15-26)25(41)42)23(27)8-1-16-11-19(2-7-22(16)27)28(32,29(33,34)35)30(36,37)38/h2-7,11,17-18,23H,1,8-10,12-15H2,(H,41,42)/t17?,18?,23-,26?,27-/m1/s1 UPWOYPBEIAJQBZ-CRDIYBEASA-N 382649 US10273259, Example 358 Nuclear receptor ROR-gamma Mus musculus 136 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382649&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678649 404852005 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765260 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC2(CC1)NC(=O)NC2=O InChI=1S/C29H25F8N3O6S/c30-17-2-4-18(5-3-17)47(44,45)26-11-12-40(22(41)15-7-9-25(10-8-15)23(42)38-24(43)39-25)21(26)14-46-20-13-16(1-6-19(20)26)27(31,28(32,33)34)29(35,36)37/h1-6,13,15,21H,7-12,14H2,(H2,38,39,42,43) SGTGAONQNSKSPX-UHFFFAOYSA-N 382650 US10273259, Example 359::US10273259, Example 360::US10711020, Example 360 Nuclear receptor ROR-gamma Mus musculus 130 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382650&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678739 404852006 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765261 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC2(CC1)NC(=O)NC2=O InChI=1S/C29H25F8N3O6S/c30-17-2-4-18(5-3-17)47(44,45)26-11-12-40(22(41)15-7-9-25(10-8-15)23(42)38-24(43)39-25)21(26)14-46-20-13-16(1-6-19(20)26)27(31,28(32,33)34)29(35,36)37/h1-6,13,15,21H,7-12,14H2,(H2,38,39,42,43) SGTGAONQNSKSPX-UHFFFAOYSA-N 382650 US10273259, Example 359::US10273259, Example 360::US10711020, Example 360 Nuclear receptor ROR-gamma Mus musculus 77.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382650&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678739 404852006 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765262 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)c1nnn[nH]1 382652 US10273259, Example 361::US10711020, Example 361 Nuclear receptor ROR-gamma Mus musculus 46.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382652&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679104 404852007 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765263 CS(=O)(=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H23F8NO5S2/c1-44(40,41)21-8-2-17(3-9-21)25(39)38-15-14-26(45(42,43)22-10-6-20(30)7-11-22)23-12-5-19(16-18(23)4-13-24(26)38)27(31,28(32,33)34)29(35,36)37/h2-3,5-12,16,24H,4,13-15H2,1H3/t24-,26-/m1/s1 UWJXXUWARUDOHU-AOYPEHQESA-N 382653 US10273259, Example 362::US10711020, Example 362 Nuclear receptor ROR-gamma Mus musculus 47.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382653&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678516 404852008 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765264 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CCS(=O)(=O)C1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-10-11-36(23(37)13-16-9-12-42(38,39)15-16)22(24)8-1-17-14-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,1,8-13,15H2/t16?,22-,24-/m1/s1 UCYZQOKQNNPHCL-QOPVDAPCSA-N 382654 US10273259, Example 363::US10711020, Example 363 Nuclear receptor ROR-gamma Mus musculus 12.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382654&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678920 404852009 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765265 CC(=O)N1CC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O4S/c1-15(38)36-13-17(14-36)23(39)37-11-10-24(42(40,41)20-6-4-19(28)5-7-20)21-8-3-18(12-16(21)2-9-22(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,17,22H,2,9-11,13-14H2,1H3/t22-,24-/m1/s1 GCLHWQFHIDGCFL-ISKFKSNPSA-N 382655 US10273259, Example 364::US10711020, Example 364 Nuclear receptor ROR-gamma Mus musculus 20.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382655&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678967 404852010 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765266 CS(=O)(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O5S2/c1-44(40,41)37-13-10-17(11-14-37)24(39)38-15-12-25(45(42,43)21-6-4-20(29)5-7-21)22-8-3-19(16-18(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,16-17,23H,2,9-15H2,1H3/t23-,25-/m1/s1 VEYOQDOVAYUNHR-ILBGXUMGSA-N 382656 US10273259, Example 365::US10711020, Example 365 Nuclear receptor ROR-gamma Mus musculus 35.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382656&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678985 404852011 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765267 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CCS(=O)(=O)C1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-10-11-36(23(37)13-16-9-12-42(38,39)15-16)22(24)8-1-17-14-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,1,8-13,15H2/t16?,22-,24-/m1/s1 UCYZQOKQNNPHCL-QOPVDAPCSA-N 382657 US10273259, Example 366::US10273259, Example 367::US10711020, Example 367 Nuclear receptor ROR-gamma Mus musculus 35.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382657&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678920 404852012 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765268 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CCS(=O)(=O)C1 InChI=1S/C27H25F8NO5S2/c28-19-3-5-20(6-4-19)43(40,41)24-10-11-36(23(37)13-16-9-12-42(38,39)15-16)22(24)8-1-17-14-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,1,8-13,15H2/t16?,22-,24-/m1/s1 UCYZQOKQNNPHCL-QOPVDAPCSA-N 382657 US10273259, Example 366::US10273259, Example 367::US10711020, Example 367 Nuclear receptor ROR-gamma Mus musculus 62.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382657&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678920 404852012 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765269 CS(=O)(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H29F7N2O5S2/c1-43(39,40)36-14-11-18(12-15-36)24(38)37-16-13-25(44(41,42)21-5-3-2-4-6-21)22-9-8-20(17-19(22)7-10-23(25)37)26(29,27(30,31)32)28(33,34)35/h2-6,8-9,17-18,23H,7,10-16H2,1H3/t23-,25-/m1/s1 GJNHXNRJADDQTA-ILBGXUMGSA-N 382659 US10273259, Example 368::US10711020, Example 368 Nuclear receptor ROR-gamma Mus musculus 24.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382659&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679004 404852013 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765270 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)S(C)(=O)=O InChI=1S/C29H30F8N2O5S2/c1-17-15-21(5-7-23(17)30)46(43,44)26-11-14-39(25(40)18-9-12-38(13-10-18)45(2,41)42)24(26)8-3-19-16-20(4-6-22(19)26)27(31,28(32,33)34)29(35,36)37/h4-7,15-16,18,24H,3,8-14H2,1-2H3 ZNTDQSZSJDSAST-UHFFFAOYSA-N 382660 US10273259, Example 369::US10711020, Example 369 Nuclear receptor ROR-gamma Mus musculus 35.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382660&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678524 404852014 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765271 CS(=O)(=O)N1CCC(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H28F8N2O5S2/c1-44(40,41)37-12-9-17(10-13-37)24(39)38-14-11-25(45(42,43)21-4-2-3-20(29)16-21)22-7-6-19(15-18(22)5-8-23(25)38)26(30,27(31,32)33)28(34,35)36/h2-4,6-7,15-17,23H,5,8-14H2,1H3 REHJUZSIENCEGO-UHFFFAOYSA-N 382661 US10273259, Example 370::US10711020, Example 370 Nuclear receptor ROR-gamma Mus musculus 35.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382661&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679141 404852015 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765272 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)-n1cnnn1 InChI=1S/C29H21F8N5O3S/c30-20-5-9-22(10-6-20)46(44,45)26-13-14-41(25(43)17-1-7-21(8-2-17)42-16-38-39-40-42)24(26)12-3-18-15-19(4-11-23(18)26)27(31,28(32,33)34)29(35,36)37/h1-2,4-11,15-16,24H,3,12-14H2/t24-,26-/m1/s1 ALTLNQMAVJRFDW-AOYPEHQESA-N 382662 US10273259, Example 371::US10711020, Example 371 Nuclear receptor ROR-gamma Mus musculus 109 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382662&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678853 404852016 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765273 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(cc1)C#N InChI=1S/C29H20F8N2O3S/c30-21-7-9-22(10-8-21)43(41,42)26-13-14-39(25(40)18-3-1-17(16-38)2-4-18)24(26)12-5-19-15-20(6-11-23(19)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,24H,5,12-14H2/t24-,26-/m1/s1 PSJUQUWQRJEGSX-AOYPEHQESA-N 382663 US10273259, Example 372::US10711020, Example 372 Nuclear receptor ROR-gamma Mus musculus 161 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382663&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678914 404852017 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765274 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c29-20-3-5-21(6-4-20)44(41,42)25-11-12-37(24(38)15-17-9-13-43(39,40)14-10-17)23(25)8-1-18-16-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,16-17,23H,1,8-15H2/t23-,25-/m1/s1 YHSUVAQNZOATEZ-ILBGXUMGSA-N 382664 US10273259, Example 373::US10711020, Example 373 Nuclear receptor ROR-gamma Mus musculus 55.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382664&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678928 404852018 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765275 FC(F)(F)C(F)(c1ccc2c(OCC3N(CCC23S(=O)(=O)c2ccccc2)C(=O)CC2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H26F7NO6S2/c28-25(26(29,30)31,27(32,33)34)18-6-7-20-21(15-18)41-16-22-24(20,43(39,40)19-4-2-1-3-5-19)10-11-35(22)23(36)14-17-8-12-42(37,38)13-9-17/h1-7,15,17,22H,8-14,16H2 FPLSYMMKDGXYBR-UHFFFAOYSA-N 382665 US10273259, Example 374::US10711020, Example 374 Nuclear receptor ROR-gamma Mus musculus 58.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382665&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678730 404852019 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765276 CC(=O)N1CCC(CC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F8N2O6S/c1-16(41)39-12-10-18(15-23(39)26(43)44)25(42)40-13-11-27(47(45,46)21-6-4-20(31)5-7-21)22-8-3-19(14-17(22)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,14,18,23-24H,2,9-13,15H2,1H3,(H,43,44)/t18?,23?,24-,27-/m1/s1 BMMOWNJBCYQWAL-OBTYJLIHSA-N 382666 US10273259, Example 375::US10711020, Example 375 Nuclear receptor ROR-gamma Mus musculus 60.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382666&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679136 404852020 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765277 OC(=O)c1cc(ccc1Cl)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H20ClF8NO5S/c30-22-9-1-16(14-20(22)25(41)42)24(40)39-12-11-26(45(43,44)19-6-4-18(31)5-7-19)21-8-3-17(13-15(21)2-10-23(26)39)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,23H,2,10-12H2,(H,41,42)/t23-,26-/m1/s1 PRJIYEFFGGSXHE-ZEQKJWHPSA-N 382667 US10273259, Example 376::US10711020, Example 376 Nuclear receptor ROR-gamma Mus musculus 255 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382667&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678632 404852021 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765278 COc1ccc(cc1C#N)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H22F8N2O4S/c1-44-24-10-2-18(14-19(24)16-39)26(41)40-13-12-27(45(42,43)22-7-5-21(31)6-8-22)23-9-4-20(15-17(23)3-11-25(27)40)28(32,29(33,34)35)30(36,37)38/h2,4-10,14-15,25H,3,11-13H2,1H3/t25-,27-/m1/s1 KOVISBJEYKJXRE-XNMGPUDCSA-N 382668 US10273259, Example 377::US10711020, Example 377 Nuclear receptor ROR-gamma Mus musculus 628 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382668&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678624 404852022 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765279 Oc1c(F)cc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H19F10NO4S/c29-17-3-5-18(6-4-17)44(42,43)25-9-10-39(24(41)15-12-20(30)23(40)21(31)13-15)22(25)8-1-14-11-16(2-7-19(14)25)26(32,27(33,34)35)28(36,37)38/h2-7,11-13,22,40H,1,8-10H2/t22-,25-/m1/s1 INIUSJJUSRBSBN-RCZVLFRGSA-N 382669 US10273259, Example 378::US10711020, Example 378 Nuclear receptor ROR-gamma Mus musculus 72.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382669&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678918 404852023 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765280 OC(=O)c1c(F)cc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H19F10NO5S/c30-17-3-5-18(6-4-17)46(44,45)26-9-10-40(24(41)15-12-20(31)23(25(42)43)21(32)13-15)22(26)8-1-14-11-16(2-7-19(14)26)27(33,28(34,35)36)29(37,38)39/h2-7,11-13,22H,1,8-10H2,(H,42,43)/t22-,26-/m1/s1 VYUYFJSMSPSIIO-ATIYNZHBSA-N 382670 US10273259, Example 379::US10711020, Example 379 Nuclear receptor ROR-gamma Mus musculus 55.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382670&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678867 404852024 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765281 CC(=O)N1CCC(CO)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O5S/c1-18(42)39-13-10-26(17-41,11-14-39)25(43)40-15-12-27(46(44,45)22-6-4-21(31)5-7-22)23-8-3-20(16-19(23)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,16,24,41H,2,9-15,17H2,1H3/t24-,27-/m1/s1 WXVJDKALKJHVLF-SHQCIBLASA-N 382671 US10273259, Example 380::US10711020, Example 380 Nuclear receptor ROR-gamma Mus musculus 36.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382671&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678640 404852025 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765282 CC(=O)N1CC(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C28H26F8N2O4S/c1-16(39)37-14-17(15-37)12-24(40)38-11-10-25(43(41,42)21-6-4-20(29)5-7-21)22-8-3-19(13-18(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,13,17,23H,2,9-12,14-15H2,1H3/t23-,25-/m1/s1 OAAYOFOYFQMJKB-ILBGXUMGSA-N 382672 US10273259, Example 381::US10711020, Example 381 Nuclear receptor ROR-gamma Mus musculus 89.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382672&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678648 404852026 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765283 CS(=O)(=O)N1CC(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C27H26F8N2O5S2/c1-43(39,40)36-14-16(15-36)12-23(38)37-11-10-24(44(41,42)20-6-4-19(28)5-7-20)21-8-3-18(13-17(21)2-9-22(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,13,16,22H,2,9-12,14-15H2,1H3/t22-,24-/m1/s1 KLFYGMCSUKVLQF-ISKFKSNPSA-N 382673 US10273259, Example 382::US10711020, Example 382 Nuclear receptor ROR-gamma Mus musculus 38.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382673&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678740 404852027 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765284 CS(=O)(=O)N1CCC(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CC1 InChI=1S/C29H30F8N2O5S2/c1-45(41,42)38-13-10-18(11-14-38)16-25(40)39-15-12-26(46(43,44)22-6-4-21(30)5-7-22)23-8-3-20(17-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,17-18,24H,2,9-16H2,1H3/t24-,26-/m1/s1 VIAPZQFNYCNANL-AOYPEHQESA-N 382674 US10273259, Example 383::US10711020, Example 383 Nuclear receptor ROR-gamma Mus musculus 32.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382674&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679096 404852028 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765285 OC(=O)c1cc(ccc1O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H21F8NO6S/c30-18-4-6-19(7-5-18)45(43,44)26-11-12-38(24(40)16-1-9-22(39)20(14-16)25(41)42)23(26)10-2-15-13-17(3-8-21(15)26)27(31,28(32,33)34)29(35,36)37/h1,3-9,13-14,23,39H,2,10-12H2,(H,41,42)/t23-,26-/m1/s1 SVMSLDKUKRXWKG-ZEQKJWHPSA-N 382675 US10273259, Example 384::US10711020, Example 384 Nuclear receptor ROR-gamma Mus musculus 150 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382675&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678716 404852029 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765286 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(CC#N)cc1 InChI=1S/C30H22F8N2O3S/c31-22-7-9-23(10-8-22)44(42,43)27-14-16-40(26(41)19-3-1-18(2-4-19)13-15-39)25(27)12-5-20-17-21(6-11-24(20)27)28(32,29(33,34)35)30(36,37)38/h1-4,6-11,17,25H,5,12-14,16H2/t25-,27-/m1/s1 YOCMXJSMJZMBHH-XNMGPUDCSA-N 382676 US10273259, Example 385::US10711020, Example 385 Nuclear receptor ROR-gamma Mus musculus 780 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382676&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678926 404852030 C04116 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765287 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc(C#N)c(F)c1 InChI=1S/C29H19F9N2O3S/c30-20-5-7-21(8-6-20)44(42,43)26-11-12-40(25(41)17-1-2-18(15-39)23(31)14-17)24(26)10-3-16-13-19(4-9-22(16)26)27(32,28(33,34)35)29(36,37)38/h1-2,4-9,13-14,24H,3,10-12H2/t24-,26-/m1/s1 LYQHRMBDKHMXBU-AOYPEHQESA-N 382677 US10273259, Example 386::US10711020, Example 386 Nuclear receptor ROR-gamma Mus musculus 215 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382677&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669200 404852031 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765288 NC(=O)c1c(F)cc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H20F10N2O4S/c30-17-3-5-18(6-4-17)46(44,45)26-9-10-41(25(43)15-12-20(31)23(24(40)42)21(32)13-15)22(26)8-1-14-11-16(2-7-19(14)26)27(33,28(34,35)36)29(37,38)39/h2-7,11-13,22H,1,8-10H2,(H2,40,42)/t22-,26-/m1/s1 PSWQLEYTOSCYAF-ATIYNZHBSA-N 382678 US10273259, Example 387::US10711020, Example 387 Nuclear receptor ROR-gamma Mus musculus 25.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382678&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678745 404852032 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765289 CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C29H29F8NO5S2/c1-16-13-21(5-7-23(16)30)45(42,43)26-10-11-38(25(39)19-9-12-44(40,41)17(2)14-19)24(26)8-3-18-15-20(4-6-22(18)26)27(31,28(32,33)34)29(35,36)37/h4-7,13,15,17,19,24H,3,8-12,14H2,1-2H3 ZLUXNHCJQCSDDZ-UHFFFAOYSA-N 382679 US10273259, Example 388::US10273259, Example 389::US10711020, Example 389 Nuclear receptor ROR-gamma Mus musculus 24.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382679&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679017 404852033 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765290 CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C29H29F8NO5S2/c1-16-13-21(5-7-23(16)30)45(42,43)26-10-11-38(25(39)19-9-12-44(40,41)17(2)14-19)24(26)8-3-18-15-20(4-6-22(18)26)27(31,28(32,33)34)29(35,36)37/h4-7,13,15,17,19,24H,3,8-12,14H2,1-2H3 ZLUXNHCJQCSDDZ-UHFFFAOYSA-N 382679 US10273259, Example 388::US10273259, Example 389::US10711020, Example 389 Nuclear receptor ROR-gamma Mus musculus 50.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382679&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679017 404852033 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765291 CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H27ClF7NO5S2/c1-16-14-18(10-13-43(16,39)40)24(38)37-12-11-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(15-17(22)2-9-23(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,15-16,18,23H,2,9-14H2,1H3 UWKRQZVWZCDNKU-UHFFFAOYSA-N 382681 US10273259, Example 390::US10273259, Example 391::US10711020, Example 391 Nuclear receptor ROR-gamma Mus musculus 27.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382681&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678635 404852034 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765292 CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H27ClF7NO5S2/c1-16-14-18(10-13-43(16,39)40)24(38)37-12-11-25(44(41,42)21-6-4-20(29)5-7-21)22-8-3-19(15-17(22)2-9-23(25)37)26(30,27(31,32)33)28(34,35)36/h3-8,15-16,18,23H,2,9-14H2,1H3 UWKRQZVWZCDNKU-UHFFFAOYSA-N 382681 US10273259, Example 390::US10273259, Example 391::US10711020, Example 391 Nuclear receptor ROR-gamma Mus musculus 13.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382681&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678635 404852034 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765293 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-16-14-20(4-6-22(16)29)44(41,42)25-10-11-37(24(38)17-8-12-43(39,40)13-9-17)23(25)7-2-18-15-19(3-5-21(18)25)26(30,27(31,32)33)28(34,35)36/h3-6,14-15,17,23H,2,7-13H2,1H3 ZLKCPAJNBVGSGB-UHFFFAOYSA-N 382573 US10273259, Example 282::US10273259, Example 392::US10711020, Example 392 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382573&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678618 404851931 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765294 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? HLPIMFURZPXHEZ-VRSFHCCXSA-N 382684 US10273259, Example 393::US10273259, Example 394::US10711020, Example 394 Nuclear receptor ROR-gamma Mus musculus 4411 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382684&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678625 404852035 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765295 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-21(8-10-23(16)31)45(43,44)27-12-13-39(25(40)17-2-4-18(5-3-17)26(41)42)24(27)11-6-19-15-20(7-9-22(19)27)28(32,29(33,34)35)30(36,37)38/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24?,27? HLPIMFURZPXHEZ-VRSFHCCXSA-N 382684 US10273259, Example 393::US10273259, Example 394::US10711020, Example 394 Nuclear receptor ROR-gamma Mus musculus 60.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382684&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678625 404852035 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765296 CC(C)c1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H33F8NO5S/c1-17(2)23-16-22(9-11-25(23)33)47(45,46)29-13-14-41(27(42)18-3-5-19(6-4-18)28(43)44)26(29)12-7-20-15-21(8-10-24(20)29)30(34,31(35,36)37)32(38,39)40/h8-11,15-19,26H,3-7,12-14H2,1-2H3,(H,43,44)/t18-,19-,26?,29? UVYWQJZRZXZHKO-HOBQQJKGSA-N 382686 US10273259, Example 395::US10711020, Example 395 Nuclear receptor ROR-gamma Mus musculus 58.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382686&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678735 404852036 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765297 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C26H23F8NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2/t16?,21-,23-/m1/s1 MQPDYHGYOCEGLJ-KDTADFBSSA-N 382687 US10273259, Example 396 Nuclear receptor ROR-gamma Mus musculus 29.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382687&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678645 404852037 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765298 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C26H23F8NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2/t16?,21-,23-/m1/s1 MQPDYHGYOCEGLJ-KDTADFBSSA-N 382688 US10273259, Example 397::US10273259, Example 400::US10711020, Example 400 Nuclear receptor ROR-gamma Mus musculus 90.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382688&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678645 404852038 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765299 OC(=O)[C@@]1(O)CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-38(23(39)16-9-11-25(42,12-10-16)24(40)41)22(26)8-1-17-15-18(2-7-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-7,15-16,22,42H,1,8-14H2,(H,40,41)/t16-,22-,25+,26-/m1/s1 UAAXXHYNFYTCMH-PNOGGZOTSA-N 382689 US10273259, Example 398::US10711020, Example 398 Nuclear receptor ROR-gamma Mus musculus 40.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382689&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678699 404852039 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765300 CC(C)c1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C32H32F9NO5S/c1-17(2)22-16-21(5-7-24(22)33)48(46,47)29-13-14-42(27(45)28(34)11-9-18(10-12-28)26(43)44)25(29)8-3-19-15-20(4-6-23(19)29)30(35,31(36,37)38)32(39,40)41/h4-7,15-18,25H,3,8-14H2,1-2H3,(H,43,44)/t18-,25?,28+,29? CAFPAOPORLESDV-BYAWYYDZSA-N 382690 US10273259, Example 399::US10711020, Example 399 Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382690&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679143 404852040 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765301 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)C1 InChI=1S/C26H23F8NO5S2/c27-18-3-5-19(6-4-18)42(39,40)23-10-11-35(22(36)16-9-12-41(37,38)14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2/t16?,21-,23-/m1/s1 MQPDYHGYOCEGLJ-KDTADFBSSA-N 382688 US10273259, Example 397::US10273259, Example 400::US10711020, Example 400 Nuclear receptor ROR-gamma Mus musculus 87.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382688&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678645 404852038 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765302 CC(C)c1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C30H31F8NO6S2/c1-17(2)21-16-20(5-7-23(21)31)47(44,45)27-9-12-39(25(40)26(41)10-13-46(42,43)14-11-26)24(27)8-3-18-15-19(4-6-22(18)27)28(32,29(33,34)35)30(36,37)38/h4-7,15-17,24,41H,3,8-14H2,1-2H3 MBBCCEFPCBIYCJ-UHFFFAOYSA-N 382692 US10273259, Example 401::US10711020, Example 401 Nuclear receptor ROR-gamma Mus musculus 134 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382692&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678644 404852041 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765303 CC(C)c1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C34H35F8NO5S/c1-19(2)23-18-22(5-7-25(23)35)49(47,48)31-15-16-43(27(44)29-9-12-30(13-10-29,14-11-29)28(45)46)26(31)8-3-20-17-21(4-6-24(20)31)32(36,33(37,38)39)34(40,41)42/h4-7,17-19,26H,3,8-16H2,1-2H3,(H,45,46) JSYKHBPCHDJROF-UHFFFAOYSA-N 382693 US10273259, Example 402::US10711020, Example 402 Nuclear receptor ROR-gamma Mus musculus 638 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382693&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678517 404852042 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765304 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C29H25Cl2F8NO5S/c30-20-5-3-18(14-21(20)31)46(44,45)26-11-12-40(24(43)25(32)9-7-15(8-10-25)23(41)42)22(26)6-1-16-13-17(2-4-19(16)26)27(33,28(34,35)36)29(37,38)39/h2-5,13-15,22H,1,6-12H2,(H,41,42)/t15-,22?,25+,26? CSTNVACFPMQTLI-CQQLRPNFSA-N 382694 US10273259, Example 403::US10711020, Example 403 Nuclear receptor ROR-gamma Mus musculus 46.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382694&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678934 404852043 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765305 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C27H24Cl2F7NO6S2/c28-19-5-3-17(14-20(19)29)45(42,43)24-7-10-37(22(38)23(39)8-11-44(40,41)12-9-23)21(24)6-1-15-13-16(2-4-18(15)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-14,21,39H,1,6-12H2 XWNSASURLTZSBY-UHFFFAOYSA-N 382695 US10273259, Example 404::US10711020, Example 404 Nuclear receptor ROR-gamma Mus musculus 34.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382695&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678629 404852044 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765306 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)c(Cl)c1 InChI=1S/C29H26Cl2F7NO5S/c30-21-9-7-19(14-22(21)31)45(43,44)26-11-12-39(24(40)15-1-3-16(4-2-15)25(41)42)23(26)10-5-17-13-18(6-8-20(17)26)27(32,28(33,34)35)29(36,37)38/h6-9,13-16,23H,1-5,10-12H2,(H,41,42)/t15-,16-,23?,26? SRLZSKMQJBCAIV-KMLPXHMCSA-N 382696 US10273259, Example 405::US10711020, Example 405 Nuclear receptor ROR-gamma Mus musculus 12.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382696&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679030 404852045 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765307 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H31F8NO5S/c1-18-16-21(4-6-23(18)33)47(45,46)29-14-15-41(25(42)27-8-11-28(12-9-27,13-10-27)26(43)44)24(29)7-2-19-17-20(3-5-22(19)29)30(34,31(35,36)37)32(38,39)40/h3-6,16-17,24H,2,7-15H2,1H3,(H,43,44) SHMZBEASAIVZGQ-UHFFFAOYSA-N 382570 US10273259, Example 279::US10273259, Example 406::US10711020, Example 406 Nuclear receptor ROR-gamma Mus musculus 31.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382570&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679057 404851928 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765308 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28F9NO5S/c1-16-14-20(4-6-22(16)31)46(44,45)27-12-13-40(25(43)26(32)10-8-17(9-11-26)24(41)42)23(27)7-2-18-15-19(3-5-21(18)27)28(33,29(34,35)36)30(37,38)39/h3-6,14-15,17,23H,2,7-13H2,1H3,(H,41,42)/t17-,23?,26+,27? HMUIKTMNWCIRAR-MTOUGUCQSA-N 382698 US10273259, Example 407 Nuclear receptor ROR-gamma Mus musculus 21.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382698&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678841 404852046 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765309 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma Mus musculus 73.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765310 OC(=O)C1CCC(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C29H27F8NO5S/c30-20-5-7-21(8-6-20)44(42,43)26-11-12-38(24(39)14-16-1-2-18(13-16)25(40)41)23(26)10-3-17-15-19(4-9-22(17)26)27(31,28(32,33)34)29(35,36)37/h4-9,15-16,18,23H,1-3,10-14H2,(H,40,41)/t16?,18?,23-,26-/m1/s1 CLLSKFXPLSGITG-LJMAUKNNSA-N 382700 US10273259, Example 409 Nuclear receptor ROR-gamma Mus musculus 143 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382700&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679015 404852048 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765311 CS(=O)(=O)N1CCC(F)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F9N2O5S2/c1-45(41,42)38-13-10-24(30,11-14-38)23(40)39-15-12-25(46(43,44)20-6-4-19(29)5-7-20)21-8-3-18(16-17(21)2-9-22(25)39)26(31,27(32,33)34)28(35,36)37/h3-8,16,22H,2,9-15H2,1H3/t22-,25-/m1/s1 AXYMWEHYHGFQIE-RCZVLFRGSA-N 382701 US10273259, Example 410::US10711020, Example 410 Nuclear receptor ROR-gamma Mus musculus 47.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382701&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678620 404852049 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765312 OC(=O)C12CC(C1)(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H23F8NO5S/c29-17-3-5-18(6-4-17)43(41,42)25-9-10-37(21(38)23-12-24(13-23,14-23)22(39)40)20(25)8-1-15-11-16(2-7-19(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,11,20H,1,8-10,12-14H2,(H,39,40)/t20-,23?,24?,25-/m1/s1 VCOSISKXMJHFPP-ZSAXZHEQSA-N 382702 US10273259, Example 411::US10711020, Example 411 Nuclear receptor ROR-gamma Mus musculus 16.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382702&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679031 404852050 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765313 CS(=O)(=O)NC1CC2(C1)CC(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O5S2/c1-46(42,43)39-21-15-26(16-21)13-18(14-26)25(41)40-11-10-27(47(44,45)22-6-4-20(31)5-7-22)23-8-3-19(12-17(23)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,12,18,21,24,39H,2,9-11,13-16H2,1H3/t18?,21?,24-,26?,27-/m1/s1 GPCHRRGMXNZQNW-VUKGGDMXSA-N 382703 US10273259, Example 412 Nuclear receptor ROR-gamma Mus musculus 34.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382703&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679142 404852051 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765314 OCC1(CCNCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O4S/c29-19-3-5-20(6-4-19)43(41,42)25-11-14-38(23(40)24(16-39)9-12-37-13-10-24)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,22,37,39H,1,8-14,16H2/t22-,25-/m1/s1 BMLHBAGBPLSTOG-RCZVLFRGSA-N 382704 US10273259, Example 413::US10711020, Example 413 Nuclear receptor ROR-gamma Mus musculus 15.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382704&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678835 404852052 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765315 CS(=O)(=O)N1CCC(CO)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H30F8N2O6S2/c1-46(42,43)38-13-10-25(17-40,11-14-38)24(41)39-15-12-26(47(44,45)21-6-4-20(30)5-7-21)22-8-3-19(16-18(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,23,40H,2,9-15,17H2,1H3/t23-,26-/m1/s1 VOIHBOVYCLWYMD-ZEQKJWHPSA-N 382705 US10273259, Example 414::US10711020, Example 414 Nuclear receptor ROR-gamma Mus musculus 20.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382705&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678942 404852053 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765316 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCOCC1 InChI=1S/C27H25F8NO4S/c28-19-3-5-20(6-4-19)41(38,39)24-11-12-36(23(37)16-9-13-40-14-10-16)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15-16,22H,1,8-14H2/t22-,24-/m1/s1 RRUIDSFYZVLBPV-ISKFKSNPSA-N 382706 US10273259, Example 415::US10711020, Example 415 Nuclear receptor ROR-gamma Mus musculus 14.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382706&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678522 404852054 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765317 NC(=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H18F8N2O4S/c24-14-3-5-15(6-4-14)38(36,37)20-9-10-33(19(35)18(32)34)17(20)8-1-12-11-13(2-7-16(12)20)21(25,22(26,27)28)23(29,30)31/h2-7,11,17H,1,8-10H2,(H2,32,34)/t17-,20-/m1/s1 RFPHYYFHTLPVST-YLJYHZDGSA-N 382707 US10273259, Example 416::US10711020, Example 416 Nuclear receptor ROR-gamma Mus musculus 135 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382707&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678660 404852055 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765318 CNC(=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H20F8N2O4S/c1-33-19(35)20(36)34-11-10-21(39(37,38)16-6-4-15(25)5-7-16)17-8-3-14(12-13(17)2-9-18(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12,18H,2,9-11H2,1H3,(H,33,35)/t18-,21-/m1/s1 QPIOFEWTPWOHDQ-WIYYLYMNSA-N 382708 US10273259, Example 417::US10711020, Example 417 Nuclear receptor ROR-gamma Mus musculus 178 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382708&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679138 404852056 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765319 NC(=O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H20F8N2O4S/c25-15-3-5-16(6-4-15)39(37,38)21-9-10-34(20(36)12-19(33)35)18(21)8-1-13-11-14(2-7-17(13)21)22(26,23(27,28)29)24(30,31)32/h2-7,11,18H,1,8-10,12H2,(H2,33,35)/t18-,21-/m1/s1 QWYSBNUYXPHNOA-WIYYLYMNSA-N 382709 US10273259, Example 418::US10711020, Example 418 Nuclear receptor ROR-gamma Mus musculus 128 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382709&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679147 404852057 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765320 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ncc[nH]1 382710 US10273259, Example 419::US10711020, Example 419 Nuclear receptor ROR-gamma Mus musculus 1106 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382710&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679047 404852058 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765321 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1nnn[nH]1 382711 US10273259, Example 420::US10711020, Example 420 Nuclear receptor ROR-gamma Mus musculus 732 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382711&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678526 404852059 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765322 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1nnn[nH]1 382712 US10273259, Example 421::US10711020, Example 421 Nuclear receptor ROR-gamma Mus musculus 164 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382712&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679126 404852060 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765323 CCS(=O)(=O)c1ccc(CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C31H27F8NO5S2/c1-2-46(42,43)23-9-3-19(4-10-23)17-27(41)40-16-15-28(47(44,45)24-11-7-22(32)8-12-24)25-13-6-21(18-20(25)5-14-26(28)40)29(33,30(34,35)36)31(37,38)39/h3-4,6-13,18,26H,2,5,14-17H2,1H3/t26-,28-/m1/s1 FSYKKORHAQSADK-IXCJQBJRSA-N 382713 US10273259, Example 422::US10711020, Example 422 Nuclear receptor ROR-gamma Mus musculus 87.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382713&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678912 404852061 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765324 CC(C)(C)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO3S/c1-22(2,3)21(36)35-13-12-23(39(37,38)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-20(23)35)24(28,25(29,30)31)26(32,33)34/h5-10,14,20H,4,11-13H2,1-3H3/t20-,23-/m1/s1 ZDGCIDCRAGIXSY-NFBKMPQASA-N 382714 US10273259, Example 423::US10711020, Example 423 Nuclear receptor ROR-gamma Mus musculus 46.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382714&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679150 404852062 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765325 CC(C)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO3S/c1-14(2)21(35)34-12-11-22(38(36,37)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)34)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,3,10-12H2,1-2H3/t20-,22-/m1/s1 PZEOTOMZRDNWHA-IFMALSPDSA-N 382715 US10273259, Example 424::US10711020, Example 424 Nuclear receptor ROR-gamma Mus musculus 84.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382715&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678948 404852063 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765326 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CCC1)C(F)(F)F InChI=1S/C27H22F11NO3S/c28-17-4-6-18(7-5-17)43(41,42)23-12-13-39(21(40)22(10-1-11-22)25(30,31)32)20(23)9-2-15-14-16(3-8-19(15)23)24(29,26(33,34)35)27(36,37)38/h3-8,14,20H,1-2,9-13H2/t20-,23-/m1/s1 UCNQYSBFRVQZAI-NFBKMPQASA-N 382716 US10273259, Example 425::US10711020, Example 425 Nuclear receptor ROR-gamma Mus musculus 55.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382716&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678969 404852064 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765327 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C#C InChI=1S/C24H17F8NO3S/c1-2-20(34)33-12-11-21(37(35,36)17-7-5-16(25)6-8-17)18-9-4-15(13-14(18)3-10-19(21)33)22(26,23(27,28)29)24(30,31)32/h1,4-9,13,19H,3,10-12H2/t19-,21-/m1/s1 VTXNXWQKVCWVFI-TZIWHRDSSA-N 382717 US10273259, Example 426::US10711020, Example 426 Nuclear receptor ROR-gamma Mus musculus 956 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382717&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678520 404852065 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765328 CC#CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H19F8NO3S/c1-2-3-21(35)34-13-12-22(38(36,37)18-8-6-17(26)7-9-18)19-10-5-16(14-15(19)4-11-20(22)34)23(27,24(28,29)30)25(31,32)33/h5-10,14,20H,4,11-13H2,1H3/t20-,22-/m1/s1 ZMJVPQUCVMDEPO-IFMALSPDSA-N 382718 US10273259, Example 427::US10711020, Example 427 Nuclear receptor ROR-gamma Mus musculus 272 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382718&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678956 404852066 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765329 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC1 InChI=1S/C25H21F8NO3S/c26-17-5-7-18(8-6-17)38(36,37)22-11-12-34(21(35)14-1-2-14)20(22)10-3-15-13-16(4-9-19(15)22)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,1-3,10-12H2/t20-,22-/m1/s1 DGVMLHUCFQGWJB-IFMALSPDSA-N 382719 US10273259, Example 428::US10711020, Example 428 Nuclear receptor ROR-gamma Mus musculus 50.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382719&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679152 404852067 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765330 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC(F)(F)C1 InChI=1S/C26H21F10NO3S/c27-17-3-5-18(6-4-17)41(39,40)23-9-10-37(21(38)15-12-22(28,29)13-15)20(23)8-1-14-11-16(2-7-19(14)23)24(30,25(31,32)33)26(34,35)36/h2-7,11,15,20H,1,8-10,12-13H2/t20-,23-/m1/s1 QSDJZAIYWPFVKD-NFBKMPQASA-N 382720 US10273259, Example 429::US10711020, Example 429 Nuclear receptor ROR-gamma Mus musculus 173 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382720&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679122 404852068 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765331 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CCC1)C#N InChI=1S/C27H22F8N2O3S/c28-18-4-6-19(7-5-18)41(39,40)24-12-13-37(22(38)23(15-36)10-1-11-23)21(24)9-2-16-14-17(3-8-20(16)24)25(29,26(30,31)32)27(33,34)35/h3-8,14,21H,1-2,9-13H2/t21-,24-/m1/s1 CKFFJKYUQOUQAR-ZJSXRUAMSA-N 382721 US10273259, Example 430::US10711020, Example 430 Nuclear receptor ROR-gamma Mus musculus 77.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382721 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382721&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679036 404852069 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765332 CC1(C)C(C(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1(C)C InChI=1S/C29H29F8NO3S/c1-24(2)22(25(24,3)4)23(39)38-14-13-26(42(40,41)19-9-7-18(30)8-10-19)20-11-6-17(15-16(20)5-12-21(26)38)27(31,28(32,33)34)29(35,36)37/h6-11,15,21-22H,5,12-14H2,1-4H3/t21-,26-/m1/s1 UOCIENQBFQTBKD-QFQXNSOFSA-N 382722 US10273259, Example 431::US10711020, Example 431 Nuclear receptor ROR-gamma Mus musculus 44.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382722&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679103 404852070 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765333 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1[C@H]2COC[C@@H]12 InChI=1S/C27H23F8NO4S/c28-16-3-5-17(6-4-16)41(38,39)24-9-10-36(23(37)22-18-12-40-13-19(18)22)21(24)8-1-14-11-15(2-7-20(14)24)25(29,26(30,31)32)27(33,34)35/h2-7,11,18-19,21-22H,1,8-10,12-13H2/t18-,19+,21-,22-,24-/m1/s1 MCVPKUDMFTZCOJ-MMUOCADFSA-N 382723 US10273259, Example 432::US10711020, Example 432 Nuclear receptor ROR-gamma Mus musculus 52.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382723&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679037 404852071 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765334 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC1 InChI=1S/C26H23F8NO3S/c27-18-6-8-19(9-7-18)39(37,38)23-12-13-35(22(36)15-2-1-3-15)21(23)11-4-16-14-17(5-10-20(16)23)24(28,25(29,30)31)26(32,33)34/h5-10,14-15,21H,1-4,11-13H2/t21-,23-/m1/s1 MZVOIROIUZWGJI-FYYLOGMGSA-N 382724 US10273259, Example 433::US10711020, Example 433 Nuclear receptor ROR-gamma Mus musculus 63.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382724&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679168 404852072 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765335 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC(F)(F)F InChI=1S/C24H18F11NO3S/c25-15-3-5-16(6-4-15)40(38,39)20-9-10-36(19(37)12-21(26,27)28)18(20)8-1-13-11-14(2-7-17(13)20)22(29,23(30,31)32)24(33,34)35/h2-7,11,18H,1,8-10,12H2/t18-,20-/m1/s1 BQRALVPHWJHCKT-UYAOXDASSA-N 382725 US10273259, Example 434::US10711020, Example 434 Nuclear receptor ROR-gamma Mus musculus 86.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382725&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678651 404852073 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765336 CC1(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F8NO3S/c1-22(10-11-22)21(36)35-13-12-23(39(37,38)18-6-4-17(27)5-7-18)19-8-3-16(14-15(19)2-9-20(23)35)24(28,25(29,30)31)26(32,33)34/h3-8,14,20H,2,9-13H2,1H3/t20-,23-/m1/s1 KSVOVRFPDQTPFV-NFBKMPQASA-N 382726 US10273259, Example 435::US10711020, Example 435 Nuclear receptor ROR-gamma Mus musculus 188 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382726&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679131 404852074 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765337 FC1CC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H22F9NO3S/c27-17-3-5-19(6-4-17)40(38,39)23-9-10-36(22(37)15-12-18(28)13-15)21(23)8-1-14-11-16(2-7-20(14)23)24(29,25(30,31)32)26(33,34)35/h2-7,11,15,18,21H,1,8-10,12-13H2/t15?,18?,21-,23-/m1/s1 IHVZWPJUIUZODC-XGZPXUMOSA-N 382727 US10273259, Example 436::US10273259, Example 437::US10711020, Example 437 Nuclear receptor ROR-gamma Mus musculus 49.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382727&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678655 404852075 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765338 FC1CC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H22F9NO3S/c27-17-3-5-19(6-4-17)40(38,39)23-9-10-36(22(37)15-12-18(28)13-15)21(23)8-1-14-11-16(2-7-20(14)23)24(29,25(30,31)32)26(33,34)35/h2-7,11,15,18,21H,1,8-10,12-13H2/t15?,18?,21-,23-/m1/s1 IHVZWPJUIUZODC-XGZPXUMOSA-N 382727 US10273259, Example 436::US10273259, Example 437::US10711020, Example 437 Nuclear receptor ROR-gamma Mus musculus 51.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382727&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678655 404852075 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765339 CC(O)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C25H20F11NO4S/c1-20(39,23(28,29)30)19(38)37-11-10-21(42(40,41)16-6-4-15(26)5-7-16)17-8-3-14(12-13(17)2-9-18(21)37)22(27,24(31,32)33)25(34,35)36/h3-8,12,18,39H,2,9-11H2,1H3/t18-,20?,21-/m1/s1 NKKSYHKSTOWHIH-TXZDUHFLSA-N 382729 US10273259, Example 438::US10711020, Example 438 Nuclear receptor ROR-gamma Mus musculus 73.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382729&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679144 404852076 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765340 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CC1)C(F)(F)F InChI=1S/C26H20F11NO3S/c27-16-3-5-17(6-4-16)42(40,41)22-11-12-38(20(39)21(9-10-21)24(29,30)31)19(22)8-1-14-13-15(2-7-18(14)22)23(28,25(32,33)34)26(35,36)37/h2-7,13,19H,1,8-12H2/t19-,22-/m1/s1 GCMFUUXMYRLJTH-DENIHFKCSA-N 382730 US10273259, Example 439::US10711020, Example 439 Nuclear receptor ROR-gamma Mus musculus 214 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382730&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679160 404852077 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765341 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1COC1 InChI=1S/C25H21F8NO4S/c26-17-3-5-18(6-4-17)39(36,37)22-9-10-34(21(35)15-12-38-13-15)20(22)8-1-14-11-16(2-7-19(14)22)23(27,24(28,29)30)25(31,32)33/h2-7,11,15,20H,1,8-10,12-13H2/t20-,22-/m1/s1 CSJOJZVZBOTLNM-IFMALSPDSA-N 382731 US10273259, Example 440::US10711020, Example 440 Nuclear receptor ROR-gamma Mus musculus 72.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382731&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678960 404852078 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765342 OC(=O)C1(CCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F8NO5S/c28-17-4-6-18(7-5-17)42(40,41)24-12-13-36(21(37)23(22(38)39)10-1-11-23)20(24)9-2-15-14-16(3-8-19(15)24)25(29,26(30,31)32)27(33,34)35/h3-8,14,20H,1-2,9-13H2,(H,38,39)/t20-,24-/m1/s1 MGEITVYVWKMTKQ-HYBUGGRVSA-N 382732 US10273259, Example 441::US10711020, Example 441 Nuclear receptor ROR-gamma Mus musculus 159 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382732&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679167 404852079 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765343 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CCCC1)C(F)(F)F InChI=1S/C28H24F11NO3S/c29-18-5-7-19(8-6-18)44(42,43)24-13-14-40(22(41)23(26(31,32)33)11-1-2-12-23)21(24)10-3-16-15-17(4-9-20(16)24)25(30,27(34,35)36)28(37,38)39/h4-9,15,21H,1-3,10-14H2/t21-,24-/m1/s1 VMKQXKDIUXZZDG-ZJSXRUAMSA-N 382733 US10273259, Example 442::US10711020, Example 442 Nuclear receptor ROR-gamma Mus musculus 145 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382733&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678662 404852080 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765344 CC(C)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C26H22F11NO3S/c1-21(2,24(29,30)31)20(39)38-12-11-22(42(40,41)17-7-5-16(27)6-8-17)18-9-4-15(13-14(18)3-10-19(22)38)23(28,25(32,33)34)26(35,36)37/h4-9,13,19H,3,10-12H2,1-2H3/t19-,22-/m1/s1 NPEVFGJGEHYCQW-DENIHFKCSA-N 382734 US10273259, Example 443::US10273259, Example 475::US10711020, Example 476 Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382734&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678665 404852081 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765345 CC(C)(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO4S/c1-21(2,36)20(35)34-12-11-22(39(37,38)17-7-5-16(26)6-8-17)18-9-4-15(13-14(18)3-10-19(22)34)23(27,24(28,29)30)25(31,32)33/h4-9,13,19,36H,3,10-12H2,1-2H3/t19-,22-/m1/s1 ISLBBCMLQNJKEJ-DENIHFKCSA-N 382735 US10273259, Example 444::US10711020, Example 444 Nuclear receptor ROR-gamma Mus musculus 45.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382735&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678675 404852082 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765346 OCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H19F8NO4S/c24-15-3-5-16(6-4-15)37(35,36)20-9-10-32(19(34)12-33)18(20)8-1-13-11-14(2-7-17(13)20)21(25,22(26,27)28)23(29,30)31/h2-7,11,18,33H,1,8-10,12H2/t18-,20-/m1/s1 CKKJHGTWWADHAE-UYAOXDASSA-N 382736 US10273259, Example 445::US10711020, Example 445 Nuclear receptor ROR-gamma Mus musculus 70.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382736&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678754 404852083 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765347 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCC(F)(F)CC1 InChI=1S/C28H25F10NO3S/c29-19-3-5-20(6-4-19)43(41,42)25-13-14-39(23(40)16-9-11-24(30,31)12-10-16)22(25)8-1-17-15-18(2-7-21(17)25)26(32,27(33,34)35)28(36,37)38/h2-7,15-16,22H,1,8-14H2/t22-,25-/m1/s1 AOPFHWGNRUOVBK-RCZVLFRGSA-N 382737 US10273259, Example 446::US10711020, Example 446 Nuclear receptor ROR-gamma Mus musculus 143 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382737&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678659 404852084 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765348 O[C@@H](C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C24H18F11NO4S/c25-14-3-5-15(6-4-14)41(39,40)20-9-10-36(19(38)18(37)22(27,28)29)17(20)8-1-12-11-13(2-7-16(12)20)21(26,23(30,31)32)24(33,34)35/h2-7,11,17-18,37H,1,8-10H2/t17-,18+,20-/m1/s1 XDCCRDKBCXJGQP-WSTZPKSXSA-N 382738 US10273259, Example 447::US10711020, Example 447 Nuclear receptor ROR-gamma Mus musculus 14.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382738&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679156 404852085 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765349 CS(=O)(=O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H21F8NO5S2/c1-39(35,36)13-20(34)33-11-10-21(40(37,38)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)33)22(26,23(27,28)29)24(30,31)32/h3-8,12,19H,2,9-11,13H2,1H3/t19-,21-/m1/s1 LASKNXVSIDQPHY-TZIWHRDSSA-N 382739 US10273259, Example 448::US10711020, Example 448 Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382739&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679162 404852086 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765350 CC(C)S(=O)(=O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO5S2/c1-15(2)41(37,38)14-22(36)35-12-11-23(42(39,40)19-7-5-18(27)6-8-19)20-9-4-17(13-16(20)3-10-21(23)35)24(28,25(29,30)31)26(32,33)34/h4-9,13,15,21H,3,10-12,14H2,1-2H3/t21-,23-/m1/s1 XBPPGWNYVTWTKT-FYYLOGMGSA-N 382740 US10273259, Example 449::US10711020, Example 449 Nuclear receptor ROR-gamma Mus musculus 30.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382740&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678658 404852087 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765351 CC(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)S(C)(=O)=O InChI=1S/C25H23F8NO5S2/c1-14(40(2,36)37)21(35)34-12-11-22(41(38,39)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)34)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,3,10-12H2,1-2H3/t14?,20-,22-/m1/s1 UHPWILVTCPQMJG-FRPDIZBGSA-N 382741 US10273259, Example 450::US10711020, Example 450 Nuclear receptor ROR-gamma Mus musculus 32.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382741&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679171 404852088 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765352 Fc1ccc(cc1)S(=O)(=O)CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H22F9NO5S2/c30-19-3-7-21(8-4-19)45(41,42)16-25(40)39-14-13-26(46(43,44)22-9-5-20(31)6-10-22)23-11-2-18(15-17(23)1-12-24(26)39)27(32,28(33,34)35)29(36,37)38/h2-11,15,24H,1,12-14,16H2/t24-,26-/m1/s1 IUCRZXFSMDUWGK-AOYPEHQESA-N 382742 US10273259, Example 451::US10711020, Example 451 Nuclear receptor ROR-gamma Mus musculus 177 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382742&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678963 404852089 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765353 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CS(=O)(=O)c1ccccc1 InChI=1S/C29H23F8NO5S2/c30-20-8-10-22(11-9-20)45(42,43)26-14-15-38(25(39)17-44(40,41)21-4-2-1-3-5-21)24(26)13-6-18-16-19(7-12-23(18)26)27(31,28(32,33)34)29(35,36)37/h1-5,7-12,16,24H,6,13-15,17H2/t24-,26-/m1/s1 QWXOCEUSGWHMSH-AOYPEHQESA-N 382743 US10273259, Example 452::US10711020, Example 452 Nuclear receptor ROR-gamma Mus musculus 153 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382743&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679064 404852090 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765354 CC(CS(=O)(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H26ClF8NO5S2/c1-18(17-47(43,44)23-8-4-21(32)5-9-23)27(42)41-15-14-28(48(45,46)24-10-6-22(33)7-11-24)25-12-3-20(16-19(25)2-13-26(28)41)29(34,30(35,36)37)31(38,39)40/h3-12,16,18,26H,2,13-15,17H2,1H3/t18?,26-,28-/m1/s1 HJYAVGSDGOESHW-QAFNWWFMSA-N 382744 US10273259, Example 453::US10711020, Example 453 Nuclear receptor ROR-gamma Mus musculus 443 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382744&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678889 404852091 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765355 CC(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)S(=O)(=O)c1ccc(cn1)C(F)(F)F InChI=1S/C30H23F11N2O5S2/c1-16(49(45,46)24-11-4-19(15-42-24)28(33,34)35)25(44)43-13-12-26(50(47,48)21-7-5-20(31)6-8-21)22-9-3-18(14-17(22)2-10-23(26)43)27(32,29(36,37)38)30(39,40)41/h3-9,11,14-16,23H,2,10,12-13H2,1H3/t16?,23-,26-/m1/s1 LJGSUUCDIWSYNO-OAJVEDRUSA-N 382745 US10273259, Example 454::US10711020, Example 454 Nuclear receptor ROR-gamma Mus musculus 718 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382745&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679002 404852092 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765356 CC(CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C31H26ClF8NO5S2/c1-18(47(43,44)23-8-4-21(32)5-9-23)16-27(42)41-15-14-28(48(45,46)24-10-6-22(33)7-11-24)25-12-3-20(17-19(25)2-13-26(28)41)29(34,30(35,36)37)31(38,39)40/h3-12,17-18,26H,2,13-16H2,1H3/t18?,26-,28-/m1/s1 XARPKWNUUHSWGZ-QAFNWWFMSA-N 382746 US10273259, Example 455::US10711020, Example 455 Nuclear receptor ROR-gamma Mus musculus 83.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382746&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678513 404852093 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765357 CS(=O)(=O)CCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO5S2/c1-40(36,37)13-10-21(35)34-12-11-22(41(38,39)18-6-4-17(26)5-7-18)19-8-3-16(14-15(19)2-9-20(22)34)23(27,24(28,29)30)25(31,32)33/h3-8,14,20H,2,9-13H2,1H3/t20-,22-/m1/s1 BYYTWPXMJYJHDQ-IFMALSPDSA-N 382747 US10273259, Example 456::US10711020, Example 456 Nuclear receptor ROR-gamma Mus musculus 27.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382747&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678668 404852094 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765358 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H22ClF8NO5S2/c30-19-3-7-21(8-4-19)45(41,42)16-25(40)39-14-13-26(46(43,44)22-9-5-20(31)6-10-22)23-11-2-18(15-17(23)1-12-24(26)39)27(32,28(33,34)35)29(36,37)38/h2-11,15,24H,1,12-14,16H2/t24-,26-/m1/s1 ZSLGDUXOGUBLDQ-AOYPEHQESA-N 382748 US10273259, Example 457::US10711020, Example 457 Nuclear receptor ROR-gamma Mus musculus 76.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382748&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679175 404852095 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765359 Cc1ccc(cc1)S(=O)(=O)CCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H27F8NO5S2/c1-19-2-8-23(9-3-19)46(42,43)17-14-27(41)40-16-15-28(47(44,45)24-10-6-22(32)7-11-24)25-12-5-21(18-20(25)4-13-26(28)40)29(33,30(34,35)36)31(37,38)39/h2-3,5-12,18,26H,4,13-17H2,1H3/t26-,28-/m1/s1 RPLMWNRMFNEEOY-IXCJQBJRSA-N 382749 US10273259, Example 458::US10711020, Example 458 Nuclear receptor ROR-gamma Mus musculus 101 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382749&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678670 404852096 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765360 NC(C1CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O5S2/c29-19-3-5-20(6-4-19)45(42,43)25-11-12-38(24(39)23(37)16-9-13-44(40,41)14-10-16)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15-16,22-23H,1,8-14,37H2/t22-,23?,25-/m1/s1 PSFKEQFCQTZZHB-VJBIEYCASA-N 382750 US10273259, Example 459::US10711020, Example 459 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382750&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679148 404852097 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765361 CC(=O)NC(C1CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O6S2/c1-17(41)39-25(18-10-14-47(43,44)15-11-18)26(42)40-13-12-27(48(45,46)22-6-4-21(31)5-7-22)23-8-3-20(16-19(23)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,16,18,24-25H,2,9-15H2,1H3,(H,39,41)/t24-,25?,27-/m1/s1 SUPJBGKWXGOUMU-PTYBVJFYSA-N 382751 US10273259, Example 460::US10273259, Example 461::US10711020, Example 461 Nuclear receptor ROR-gamma Mus musculus 30.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382751&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678452 404852098 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765362 CC(=O)NC(C1CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O6S2/c1-17(41)39-25(18-10-14-47(43,44)15-11-18)26(42)40-13-12-27(48(45,46)22-6-4-21(31)5-7-22)23-8-3-20(16-19(23)2-9-24(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,16,18,24-25H,2,9-15H2,1H3,(H,39,41)/t24-,25?,27-/m1/s1 SUPJBGKWXGOUMU-PTYBVJFYSA-N 382751 US10273259, Example 460::US10273259, Example 461::US10711020, Example 461 Nuclear receptor ROR-gamma Mus musculus 68.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382751&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678452 404852098 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765363 OCC(=O)NC(C1CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O7S2/c31-20-3-5-21(6-4-20)49(46,47)27-11-12-40(26(43)25(39-24(42)16-41)17-9-13-48(44,45)14-10-17)23(27)8-1-18-15-19(2-7-22(18)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,17,23,25,41H,1,8-14,16H2,(H,39,42)/t23-,25?,27-/m1/s1 PQMIEJDNNYHWBW-TXQBPDISSA-N 382753 US10273259, Example 462::US10711020, Example 462 Nuclear receptor ROR-gamma Mus musculus 59.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382753&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678939 404852099 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765364 NC1(CCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O3S/c27-17-4-6-18(7-5-17)40(38,39)23-12-13-36(21(37)22(35)10-1-11-22)20(23)9-2-15-14-16(3-8-19(15)23)24(28,25(29,30)31)26(32,33)34/h3-8,14,20H,1-2,9-13,35H2/t20-,23-/m1/s1 DHGVZZVMUBPXJT-NFBKMPQASA-N 382754 US10273259, Example 463::US10711020, Example 463 Nuclear receptor ROR-gamma Mus musculus 37.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382754&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678973 404852100 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765365 CC(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H21F8NO4S/c1-13(34)20(35)33-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)33)22(26,23(27,28)29)24(30,31)32/h3-8,12-13,19,34H,2,9-11H2,1H3/t13?,19-,21-/m1/s1 BRORFVNRYCQKTI-BTSGLNRLSA-N 382755 US10273259, Example 464::US10711020, Example 464 Nuclear receptor ROR-gamma Mus musculus 23.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382755&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678654 404852101 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765366 O[C@H](C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C24H18F11NO4S/c25-14-3-5-15(6-4-14)41(39,40)20-9-10-36(19(38)18(37)22(27,28)29)17(20)8-1-12-11-13(2-7-16(12)20)21(26,23(30,31)32)24(33,34)35/h2-7,11,17-18,37H,1,8-10H2/t17-,18-,20-/m1/s1 XDCCRDKBCXJGQP-QWFCFKBJSA-N 382756 US10273259, Example 465::US10711020, Example 465 Nuclear receptor ROR-gamma Mus musculus 53.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382756&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678681 404852102 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765367 C[C@@](O)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C25H20F11NO4S/c1-20(39,23(28,29)30)19(38)37-11-10-21(42(40,41)16-6-4-15(26)5-7-16)17-8-3-14(12-13(17)2-9-18(21)37)22(27,24(31,32)33)25(34,35)36/h3-8,12,18,39H,2,9-11H2,1H3/t18-,20-,21-/m1/s1 NKKSYHKSTOWHIH-HMXCVIKNSA-N 382757 US10273259, Example 466::US10711020, Example 466 Nuclear receptor ROR-gamma Mus musculus 28.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382757&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679166 404852103 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765368 CCC(C)(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c1-3-22(2,37)21(36)35-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-20(23)35)24(28,25(29,30)31)26(32,33)34/h5-10,14,20,37H,3-4,11-13H2,1-2H3/t20-,22?,23-/m1/s1 UXFWEECXIIFGOQ-WPLVIQRKSA-N 382758 US10273259, Example 467::US10711020, Example 467 Nuclear receptor ROR-gamma Mus musculus 50.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382758&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678756 404852104 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765369 OC1(CCCCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO4S/c29-19-6-8-20(9-7-19)42(40,41)25-14-15-37(23(38)24(39)12-2-1-3-13-24)22(25)11-4-17-16-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h5-10,16,22,39H,1-4,11-15H2/t22-,25-/m1/s1 RAFFAZLEYOPBCR-RCZVLFRGSA-N 382759 US10273259, Example 468::US10711020, Example 468 Nuclear receptor ROR-gamma Mus musculus 22.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382759&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679170 404852105 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765370 OC(C1CCOCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8NO5S/c29-19-3-5-20(6-4-19)43(40,41)25-11-12-37(24(39)23(38)16-9-13-42-14-10-16)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15-16,22-23,38H,1,8-14H2/t22-,23?,25-/m1/s1 MGKWDVNKZNFTMG-VJBIEYCASA-N 382760 US10273259, Example 469::US10711020, Example 469 Nuclear receptor ROR-gamma Mus musculus 21.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382760&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678958 404852106 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765371 OC1(CCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F8NO4S/c27-17-4-6-18(7-5-17)40(38,39)23-12-13-35(21(36)22(37)10-1-11-22)20(23)9-2-15-14-16(3-8-19(15)23)24(28,25(29,30)31)26(32,33)34/h3-8,14,20,37H,1-2,9-13H2/t20-,23-/m1/s1 CHTHFBQVPAHCST-NFBKMPQASA-N 382761 US10273259, Example 470::US10711020, Example 470 Nuclear receptor ROR-gamma Mus musculus 25.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382761&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678975 404852107 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765372 OC1(CCOCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO5S/c28-18-3-5-19(6-4-18)42(39,40)24-9-12-36(22(37)23(38)10-13-41-14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,38H,1,8-14H2/t21-,24-/m1/s1 QEUMJSPHXVPHCH-ZJSXRUAMSA-N 382762 US10273259, Example 471::US10711020, Example 471 Nuclear receptor ROR-gamma Mus musculus 30.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382762&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669279 404852108 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765373 OC1(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H21F8NO4S/c26-16-3-5-17(6-4-16)39(37,38)22-11-12-34(20(35)21(36)9-10-21)19(22)8-1-14-13-15(2-7-18(14)22)23(27,24(28,29)30)25(31,32)33/h2-7,13,19,36H,1,8-12H2/t19-,22-/m1/s1 XHLRBPZQDLHCDE-DENIHFKCSA-N 382763 US10273259, Example 472::US10711020, Example 472 Nuclear receptor ROR-gamma Mus musculus 25.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382763&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679032 404852109 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765374 CC(C)(C)[C@H](O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8NO4S/c1-23(2,3)21(37)22(38)36-13-12-24(41(39,40)18-8-6-17(28)7-9-18)19-10-5-16(14-15(19)4-11-20(24)36)25(29,26(30,31)32)27(33,34)35/h5-10,14,20-21,37H,4,11-13H2,1-3H3/t20-,21-,24-/m1/s1 KNSMXEWTUCOISP-PQNGQFLHSA-N 382764 US10273259, Example 473::US10711020, Example 473 Nuclear receptor ROR-gamma Mus musculus 17.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382764&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678693 404852110 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765375 O[C@H](C1CCCCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8NO4S/c30-20-8-10-21(11-9-20)43(41,42)26-14-15-38(25(40)24(39)17-4-2-1-3-5-17)23(26)13-6-18-16-19(7-12-22(18)26)27(31,28(32,33)34)29(35,36)37/h7-12,16-17,23-24,39H,1-6,13-15H2/t23-,24-,26-/m1/s1 LLEXHPCGSMBVED-DGWZTRNLSA-N 382765 US10273259, Example 474::US10711020, Example 474 Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382765&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678749 404852111 C03491 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765376 CC(C)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C26H22F11NO3S/c1-21(2,24(29,30)31)20(39)38-12-11-22(42(40,41)17-7-5-16(27)6-8-17)18-9-4-15(13-14(18)3-10-19(22)38)23(28,25(32,33)34)26(35,36)37/h4-9,13,19H,3,10-12H2,1-2H3/t19-,22-/m1/s1 NPEVFGJGEHYCQW-DENIHFKCSA-N 382734 US10273259, Example 443::US10273259, Example 475::US10711020, Example 476 Nuclear receptor ROR-gamma Mus musculus 19.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382734&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678665 404852081 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765377 C[C@](O)(C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F InChI=1S/C25H20F11NO4S/c1-20(39,23(28,29)30)19(38)37-11-10-21(42(40,41)16-6-4-15(26)5-7-16)17-8-3-14(12-13(17)2-9-18(21)37)22(27,24(31,32)33)25(34,35)36/h3-8,12,18,39H,2,9-11H2,1H3/t18-,20+,21-/m1/s1 NKKSYHKSTOWHIH-HLAWJBBLSA-N 382767 US10273259, Example 476 Nuclear receptor ROR-gamma Mus musculus 23.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382767&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678762 404852112 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765378 CCNS(=O)(=O)CCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F8N2O5S2/c1-2-35-42(38,39)14-11-22(37)36-13-12-23(43(40,41)19-7-5-18(27)6-8-19)20-9-4-17(15-16(20)3-10-21(23)36)24(28,25(29,30)31)26(32,33)34/h4-9,15,21,35H,2-3,10-14H2,1H3/t21-,23-/m1/s1 MHTYIQHQPSLEMR-FYYLOGMGSA-N 382768 US10273259, Example 477::US10711020, Example 477 Nuclear receptor ROR-gamma Mus musculus 18.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382768&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679139 404852113 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765379 CC(=O)NC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O6S2/c1-17(40)38-25(11-14-46(42,43)15-12-25)24(41)39-13-10-26(47(44,45)21-6-4-20(30)5-7-21)22-8-3-19(16-18(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,23H,2,9-15H2,1H3,(H,38,40)/t23-,26-/m1/s1 JIXDBABJZVFEGC-ZEQKJWHPSA-N 382769 US10273259, Example 478::US10711020, Example 478 Nuclear receptor ROR-gamma Mus musculus 28.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382769&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678927 404852114 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765380 NC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O5S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-37(22(38)23(36)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21H,1,8-14,36H2/t21-,24-/m1/s1 SEMDYPUEGFCPCQ-ZJSXRUAMSA-N 382770 US10273259, Example 479::US10711020, Example 479 Nuclear receptor ROR-gamma Mus musculus 35.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382770&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678776 404852115 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765381 CC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H19F8NO3S/c1-13(33)32-11-10-20(36(34,35)17-6-4-16(24)5-7-17)18-8-3-15(12-14(18)2-9-19(20)32)21(25,22(26,27)28)23(29,30)31/h3-8,12,19H,2,9-11H2,1H3/t19-,20-/m1/s1 TVONFWVDRJIBRS-WOJBJXKFSA-N 382771 US10273259, Example 482::US10711020, Example 482 Nuclear receptor ROR-gamma Mus musculus 85.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382771&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679018 404852116 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765382 CCC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H21F8NO3S/c1-2-20(34)33-12-11-21(37(35,36)17-7-5-16(25)6-8-17)18-9-4-15(13-14(18)3-10-19(21)33)22(26,23(27,28)29)24(30,31)32/h4-9,13,19H,2-3,10-12H2,1H3/t19-,21-/m1/s1 IMRSYMIEXNFKNZ-TZIWHRDSSA-N 382772 US10273259, Example 483::US10711020, Example 483 Nuclear receptor ROR-gamma Mus musculus 92.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382772&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679053 404852117 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765383 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C=C InChI=1S/C24H19F8NO3S/c1-2-20(34)33-12-11-21(37(35,36)17-7-5-16(25)6-8-17)18-9-4-15(13-14(18)3-10-19(21)33)22(26,23(27,28)29)24(30,31)32/h2,4-9,13,19H,1,3,10-12H2/t19-,21-/m1/s1 PSSQOMQMODJTRZ-TZIWHRDSSA-N 382773 US10273259, Example 484::US10711020, Example 484 Nuclear receptor ROR-gamma Mus musculus 98.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382773&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679165 404852118 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765384 CCC(C)(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c1-3-22(2,37)21(36)35-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-20(23)35)24(28,25(29,30)31)26(32,33)34/h5-10,14,20,37H,3-4,11-13H2,1-2H3/t20-,22?,23-/m1/s1 UXFWEECXIIFGOQ-WPLVIQRKSA-N 382774 US10273259, Example 485::US10273259, Example 486::US10711020, Example 486 Nuclear receptor ROR-gamma Mus musculus 36.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382774&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678756 404852119 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765385 CCC(C)(O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c1-3-22(2,37)21(36)35-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-20(23)35)24(28,25(29,30)31)26(32,33)34/h5-10,14,20,37H,3-4,11-13H2,1-2H3/t20-,22?,23-/m1/s1 UXFWEECXIIFGOQ-WPLVIQRKSA-N 382774 US10273259, Example 485::US10273259, Example 486::US10711020, Example 486 Nuclear receptor ROR-gamma Mus musculus 51.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382774&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678756 404852119 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765386 OC(=O)C12CCC(CC1)(C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-19-3-5-20(6-4-19)45(43,44)27-13-14-39(23(40)25-9-11-26(16-25,12-10-25)24(41)42)22(27)8-1-17-15-18(2-7-21(17)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,22H,1,8-14,16H2,(H,41,42)/t22-,25?,26?,27-/m1/s1 ISVYIUNLJVBPHV-LPDNJITPSA-N 382776 US10273259, Example 487::US10711020, Example 487 Nuclear receptor ROR-gamma Mus musculus 283 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382776&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678523 404852120 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765387 OC(=O)[C@@H]1[C@H]2C[C@@H](C[C@@H]12)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO5S/c30-17-3-5-18(6-4-17)44(42,43)26-9-10-38(24(39)15-12-19-20(13-15)23(19)25(40)41)22(26)8-1-14-11-16(2-7-21(14)26)27(31,28(32,33)34)29(35,36)37/h2-7,11,15,19-20,22-23H,1,8-10,12-13H2,(H,40,41)/t15-,19-,20+,22-,23+,26-/m1/s1 UHLJJPHZGHFJLZ-UCCTXEPQSA-N 382777 US10273259, Example 488::US10711020, Example 488 Nuclear receptor ROR-gamma Mus musculus 145 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382777&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678769 404852121 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765388 CCC[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C32H33F8NO5S/c1-2-13-28(14-11-19(12-15-28)26(42)43)27(44)41-17-16-29(47(45,46)23-7-5-22(33)6-8-23)24-9-4-21(18-20(24)3-10-25(29)41)30(34,31(35,36)37)32(38,39)40/h4-9,18-19,25H,2-3,10-17H2,1H3,(H,42,43)/t19-,25-,28-,29-/m1/s1 CLXDXGGRGJNBCB-LNJOXGPJSA-N 382778 US10273259, Example 489::US10711020, Example 489 Nuclear receptor ROR-gamma Mus musculus 438 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382778&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678688 404852122 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765389 COCC1(CCC(CC1)C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H31F8NO6S/c1-46-17-27(12-10-18(11-13-27)25(41)42)26(43)40-15-14-28(47(44,45)22-6-4-21(32)5-7-22)23-8-3-20(16-19(23)2-9-24(28)40)29(33,30(34,35)36)31(37,38)39/h3-8,16,18,24H,2,9-15,17H2,1H3,(H,41,42)/t18?,24-,27?,28-/m1/s1 CLSLHBGKFQLFSL-ISBMXXRTSA-N 382779 US10273259, Example 490 Nuclear receptor ROR-gamma Mus musculus 195 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382779&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678698 404852123 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765390 OC(=O)C1(O)CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-19-3-5-20(6-4-19)45(43,44)26-13-14-38(23(39)16-9-11-25(42,12-10-16)24(40)41)22(26)8-1-17-15-18(2-7-21(17)26)27(31,28(32,33)34)29(35,36)37/h2-7,15-16,22,42H,1,8-14H2,(H,40,41)/t16?,22-,25?,26-/m1/s1 UAAXXHYNFYTCMH-YLDCRMAMSA-N 382780 US10273259, Example 491 Nuclear receptor ROR-gamma Mus musculus 121 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382780&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678699 404852124 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765391 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCOC1 InChI=1S/C26H23F8NO4S/c27-18-3-5-19(6-4-18)40(37,38)23-10-11-35(22(36)16-9-12-39-14-16)21(23)8-1-15-13-17(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,16,21H,1,8-12,14H2/t16?,21-,23-/m1/s1 BKWHSBXYDDIEGE-KDTADFBSSA-N 382781 US10273259, Example 492::US10711020, Example 492 Nuclear receptor ROR-gamma Mus musculus 52.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382781&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678703 404852125 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765392 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CCOCC1)C#N InChI=1S/C28H24F8N2O4S/c29-19-3-5-20(6-4-19)43(40,41)25-9-12-38(23(39)24(16-37)10-13-42-14-11-24)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,22H,1,8-14H2/t22-,25-/m1/s1 DHERJBCEZJWWBP-RCZVLFRGSA-N 382782 US10273259, Example 493::US10711020, Example 493 Nuclear receptor ROR-gamma Mus musculus 103 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382782&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678705 404852126 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765393 CN1[C@@H](C[C@H](O)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c1-36-19(13-20(38)23(36)40)22(39)37-11-10-24(43(41,42)17-6-4-16(28)5-7-17)18-8-3-15(12-14(18)2-9-21(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,12,19-21,38H,2,9-11,13H2,1H3/t19-,20-,21+,24+/m0/s1 KAKUQEOIEAWDFB-VMIIQTFKSA-N 382537 US10273259, Example 246::US10273259, Example 494::US10711020, Example 494 Nuclear receptor ROR-gamma Mus musculus 23.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382537&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678788 404851898 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765394 C[C@H]1C[C@H](C[C@@H](C)S1(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8NO5S2/c1-16-13-19(14-17(2)44(16,40)41)25(39)38-12-11-26(45(42,43)22-7-5-21(30)6-8-22)23-9-4-20(15-18(23)3-10-24(26)38)27(31,28(32,33)34)29(35,36)37/h4-9,15-17,19,24H,3,10-14H2,1-2H3/t16-,17+,19+,24-,26-/m1/s1 MQFDMIAESKMWEC-CHQNCTNHSA-N 382784 US10273259, Example 495::US10711020, Example 495 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382784&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679149 404852127 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765395 OC1(CCNCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O4S/c28-18-3-5-19(6-4-18)42(40,41)24-11-14-37(22(38)23(39)9-12-36-13-10-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,36,39H,1,8-14H2/t21-,24-/m1/s1 MSSLTMDBRWZWPK-ZJSXRUAMSA-N 382785 US10273259, Example 496::US10711020, Example 496 Nuclear receptor ROR-gamma Mus musculus 77.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382785&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678981 404852128 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765396 C[C@H]1C[C@H](C[C@@H](C)S1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H29ClF7NO5S2/c1-16-13-19(14-17(2)44(16,40)41)25(39)38-12-11-26(45(42,43)22-7-5-21(30)6-8-22)23-9-4-20(15-18(23)3-10-24(26)38)27(31,28(32,33)34)29(35,36)37/h4-9,15-17,19,24H,3,10-14H2,1-2H3/t16-,17+,19+,24?,26? ZEUUQSLMFOAELZ-XLSVLJSMSA-N 382786 US10273259, Example 497::US10711020, Example 497 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382786&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679207 404852129 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765397 OCCN1[C@@H](C[C@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F9N2O5S/c29-17-3-5-18(6-4-17)45(43,44)25-9-10-39(24(42)21-14-20(30)23(41)38(21)11-12-40)22(25)8-1-15-13-16(2-7-19(15)25)26(31,27(32,33)34)28(35,36)37/h2-7,13,20-22,40H,1,8-12,14H2/t20-,21-,22+,25+/m0/s1 OZWSYBBGXBLWCW-VRIJDZSUSA-N 382787 US10273259, Example 498::US10711020, Example 498 Nuclear receptor ROR-gamma Mus musculus 42.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382787&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678678 404852130 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765398 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)c2ccc3cncn3c2)c1)C(F)(F)F InChI=1S/C29H21ClF7N3O3S/c30-20-4-7-22(8-5-20)44(42,43)26-11-12-40(25(41)18-1-6-21-14-38-16-39(21)15-18)24(26)10-2-17-13-19(3-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h1,3-9,13-16,24H,2,10-12H2 KPDGUAFDYQGWEV-UHFFFAOYSA-N 382788 US10273259, Example 499::US10711020, Example 499 Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382788&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679146 404852131 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765399 CC1(C)OC(=O)CC1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c1-24(2)20(14-22(38)42-24)23(39)37-12-11-25(43(40,41)18-7-5-17(29)6-8-18)19-9-4-16(13-15(19)3-10-21(25)37)26(30,27(31,32)33)28(34,35)36/h4-9,13,20-21H,3,10-12,14H2,1-2H3/t20?,21-,25-/m1/s1 LBTFXZSCWMJOLQ-NOCHFJEPSA-N 382789 US10273259, Example 500::US10711020, Example 500 Nuclear receptor ROR-gamma Mus musculus 53.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382789&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679039 404852132 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765400 CC(C)C1CC(CCO1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H31F8NO4S/c1-17(2)24-16-19(11-14-43-24)26(40)39-13-12-27(44(41,42)22-7-5-21(31)6-8-22)23-9-4-20(15-18(23)3-10-25(27)39)28(32,29(33,34)35)30(36,37)38/h4-9,15,17,19,24-25H,3,10-14,16H2,1-2H3/t19?,24?,25-,27-/m1/s1 BJJKMASKHJPBMA-OTAHFMTBSA-N 382790 US10273259, Example 501::US10711020, Example 501 Nuclear receptor ROR-gamma Mus musculus 37.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382790&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678712 404852133 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765401 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2cncn2c1 InChI=1S/C29H21F8N3O3S/c30-20-4-7-22(8-5-20)44(42,43)26-11-12-40(25(41)18-1-6-21-14-38-16-39(21)15-18)24(26)10-2-17-13-19(3-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h1,3-9,13-16,24H,2,10-12H2/t24-,26-/m1/s1 RXUWLKZLOJWMFP-AOYPEHQESA-N 382791 US10273259, Example 502::US10711020, Example 502 Nuclear receptor ROR-gamma Mus musculus 20.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382791&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678706 404852134 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765402 CO[C@H]1C[C@H](N(C)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c1-37-20(14-21(43-2)24(37)40)23(39)38-12-11-25(44(41,42)18-7-5-17(29)6-8-18)19-9-4-16(13-15(19)3-10-22(25)38)26(30,27(31,32)33)28(34,35)36/h4-9,13,20-22H,3,10-12,14H2,1-2H3/t20-,21-,22+,25+/m0/s1 WQGALPRYPWUIGZ-VRIJDZSUSA-N 382792 US10273259, Example 503::US10711020, Example 503 Nuclear receptor ROR-gamma Mus musculus 83.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382792&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678785 404852135 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765403 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F9NO5S/c31-20-4-6-21(7-5-20)46(44,45)27-12-1-15-40(25(43)26(32)13-10-17(11-14-26)24(41)42)23(27)9-2-18-16-19(3-8-22(18)27)28(33,29(34,35)36)30(37,38)39/h3-8,16-17,23H,1-2,9-15H2,(H,41,42)/t17-,23?,26+,27? XTHIANFXMPOKFF-MTOUGUCQSA-N 382793 US10273259, Example 504::US10711020, Example 504 Nuclear receptor ROR-gamma Mus musculus 57.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382793&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678775 404852136 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765404 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CN1CCS(=O)(=O)CC1 InChI=1S/C27H26F8N2O5S2/c28-19-3-5-20(6-4-19)44(41,42)24-9-10-37(23(38)16-36-11-13-43(39,40)14-12-36)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,22H,1,8-14,16H2/t22-,24-/m1/s1 TUVYEZREOAAMDT-ISKFKSNPSA-N 382794 US10273259, Example 505::US10711020, Example 505 Nuclear receptor ROR-gamma Mus musculus 88.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382794&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678802 404852137 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765405 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO6S/c1-16-14-20(4-6-22(16)31)46(44,45)27-12-13-39(25(42)26(43)10-8-17(9-11-26)24(40)41)23(27)7-2-18-15-19(3-5-21(18)27)28(32,29(33,34)35)30(36,37)38/h3-6,14-15,17,23,43H,2,7-13H2,1H3,(H,40,41)/t17-,23?,26+,27? ZXRWJHQYBPGKEZ-MTOUGUCQSA-N 382795 US10273259, Example 506::US10711020, Example 506 Nuclear receptor ROR-gamma Mus musculus 223 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382795&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679066 404852138 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765406 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H28F9NO5S/c31-20-3-1-4-21(16-20)46(44,45)27-11-2-14-40(25(43)26(32)12-9-17(10-13-26)24(41)42)23(27)8-5-18-15-19(6-7-22(18)27)28(33,29(34,35)36)30(37,38)39/h1,3-4,6-7,15-17,23H,2,5,8-14H2,(H,41,42)/t17-,23?,26+,27? NUATZYDOTDTTAN-MTOUGUCQSA-N 382796 US10273259, Example 507::US10711020, Example 507 Nuclear receptor ROR-gamma Mus musculus 135 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382796&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678793 404852139 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765407 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-18-6-8-19(9-7-18)44(42,43)25-11-12-38(23(39)15-1-3-16(4-2-15)24(40)41)22(25)14-37-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22,37H,1-4,11-12,14H2,(H,40,41)/t15-,16-,22?,25? WCICLOUJTXBWJG-QAXNPQHNSA-N 382797 US10273259, Example 508::US10273259, Example 509::US10711020, Example 509 Nuclear receptor ROR-gamma Mus musculus 2830 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382797&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669120 404852140 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765408 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-18-6-8-19(9-7-18)44(42,43)25-11-12-38(23(39)15-1-3-16(4-2-15)24(40)41)22(25)14-37-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22,37H,1-4,11-12,14H2,(H,40,41)/t15-,16-,22?,25? WCICLOUJTXBWJG-QAXNPQHNSA-N 382797 US10273259, Example 508::US10273259, Example 509::US10711020, Example 509 Nuclear receptor ROR-gamma Mus musculus 255 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382797&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669120 404852140 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765409 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H28F8N2O5S/c31-18-2-4-19(5-3-18)46(44,45)27-13-14-40(23(41)25-7-10-26(11-8-25,12-9-25)24(42)43)22(27)16-39-21-15-17(1-6-20(21)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22,39H,7-14,16H2,(H,42,43) QFRLKGZREPPACN-UHFFFAOYSA-N 382799 US10273259, Example 510::US10711020, Example 510 Nuclear receptor ROR-gamma Mus musculus 79.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382799&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678989 404852141 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765410 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F9N2O5S/c29-17-2-4-18(5-3-17)45(43,44)25-11-12-39(23(42)24(30)9-7-15(8-10-24)22(40)41)21(25)14-38-20-13-16(1-6-19(20)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21,38H,7-12,14H2,(H,40,41)/t15-,21?,24+,25? JGWWDXLCSKKCJX-DNNXONSASA-N 382800 US10273259, Example 511::US10711020, Example 511 Nuclear receptor ROR-gamma Mus musculus 41.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382800&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678747 404852142 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765411 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-25(10-8-16(9-11-25)23(40)41)24(42)39-13-12-26(45(43,44)19-5-3-18(30)4-6-19)20-7-2-17(14-21(20)38-15-22(26)39)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22,38H,8-13,15H2,1H3,(H,40,41)/t16-,22?,25-,26? UKOMWKQXEVTTJY-FVSSTLBOSA-N 382801 US10273259, Example 512::US10711020, Example 512 Nuclear receptor ROR-gamma Mus musculus 22.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382801&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679206 404852143 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765412 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C26H22F9N3O4S/c1-37-19(11-17(28)21(37)39)22(40)38-8-7-23(43(41,42)15-4-2-3-14(27)10-15)16-6-5-13(9-18(16)36-12-20(23)38)24(29,25(30,31)32)26(33,34)35/h2-6,9-10,17,19-20,36H,7-8,11-12H2,1H3/t17-,19-,20?,23?/m0/s1 RXUZMAZHAXJPIV-CRJYNEJLSA-N 382802 US10273259, Example 513::US10273259, Example 522::US10711020, Example 522 Nuclear receptor ROR-gamma Mus musculus 6561 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382802&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995603 404852144 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765413 FC(F)(F)C(F)(c1ccc2c(NCC3N(CCC23S(=O)(=O)c2ccccc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H25F7N2O5S2/c27-24(25(28,29)30,26(31,32)33)17-6-7-19-20(14-17)34-15-21-23(19,42(39,40)18-4-2-1-3-5-18)10-11-35(21)22(36)16-8-12-41(37,38)13-9-16/h1-7,14,16,21,34H,8-13,15H2 DYCBUGGWOSQUOL-UHFFFAOYSA-N 382803 US10273259, Example 514::US10711020, Example 514 Nuclear receptor ROR-gamma Mus musculus 181 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382803&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679195 404852145 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765414 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H27F7N2O5S/c29-26(27(30,31)32,28(33,34)35)18-10-11-20-21(14-18)36-15-22-25(20,43(41,42)19-4-2-1-3-5-19)12-13-37(22)23(38)16-6-8-17(9-7-16)24(39)40/h1-5,10-11,14,16-17,22,36H,6-9,12-13,15H2,(H,39,40)/t16-,17-,22?,25? QBTRKYWHRBQCJR-FECXEKGZSA-N 382804 US10273259, Example 515::US10711020, Example 515 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382804&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679194 404852146 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765415 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H24F8N2O5S2/c27-17-2-4-18(5-3-17)43(40,41)23-9-10-36(22(37)15-7-11-42(38,39)12-8-15)21(23)14-35-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21,35H,7-12,14H2 KFFBIMNAYRQYFV-UHFFFAOYSA-N 382805 US10273259, Example 516::US10711020, Example 516 Nuclear receptor ROR-gamma Mus musculus 15.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382805&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678759 404852147 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765416 Fc1cccc(c1)S(=O)(=O)C12CCN(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H24F8N2O5S2/c27-17-2-1-3-18(13-17)43(40,41)23-8-9-36(22(37)15-6-10-42(38,39)11-7-15)21(23)14-35-20-12-16(4-5-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-5,12-13,15,21,35H,6-11,14H2 SRKHSAMWTXLEMM-UHFFFAOYSA-N 382806 US10273259, Example 517::US10711020, Example 517 Nuclear receptor ROR-gamma Mus musculus 17.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382806&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678812 404852148 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765417 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H26F8N2O5S/c29-18-2-1-3-19(13-18)44(42,43)25-10-11-38(23(39)15-4-6-16(7-5-15)24(40)41)22(25)14-37-21-12-17(8-9-20(21)25)26(30,27(31,32)33)28(34,35)36/h1-3,8-9,12-13,15-16,22,37H,4-7,10-11,14H2,(H,40,41)/t15-,16-,22?,25? FWPGKAUITXDJLS-QAXNPQHNSA-N 382807 US10273259, Example 518::US10711020, Example 518 Nuclear receptor ROR-gamma Mus musculus 47.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382807&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678746 404852149 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765418 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H26F8N2O5S/c29-24(10-8-16(9-11-24)22(39)40)23(41)38-13-12-25(44(42,43)18-4-2-1-3-5-18)19-7-6-17(14-20(19)37-15-21(25)38)26(30,27(31,32)33)28(34,35)36/h1-7,14,16,21,37H,8-13,15H2,(H,39,40)/t16-,21?,24+,25? MXUDQHQOLWHXLA-QNINJKENSA-N 382808 US10273259, Example 519::US10711020, Example 519 Nuclear receptor ROR-gamma Mus musculus 41.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382808&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679185 404852150 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765419 OC(=O)[C@@]1(F)CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H26F8N2O5S/c29-24(23(40)41)10-8-16(9-11-24)22(39)38-13-12-25(44(42,43)18-4-2-1-3-5-18)19-7-6-17(14-20(19)37-15-21(25)38)26(30,27(31,32)33)28(34,35)36/h1-7,14,16,21,37H,8-13,15H2,(H,40,41)/t16-,21?,24+,25? URBJYOLSRMRGDO-QNINJKENSA-N 382809 US10273259, Example 520::US10711020, Example 520 Nuclear receptor ROR-gamma Mus musculus 57.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382809&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679021 404852151 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765420 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C28H25F9N2O5S/c29-17-2-1-3-18(13-17)45(43,44)25-10-11-39(23(42)24(30)8-6-15(7-9-24)22(40)41)21(25)14-38-20-12-16(4-5-19(20)25)26(31,27(32,33)34)28(35,36)37/h1-5,12-13,15,21,38H,6-11,14H2,(H,40,41)/t15-,21?,24+,25? JFWYSTSNUZXKCJ-DNNXONSASA-N 382810 US10273259, Example 521::US10711020, Example 521 Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382810&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678796 404852152 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765421 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C26H22F9N3O4S/c1-37-19(11-17(28)21(37)39)22(40)38-8-7-23(43(41,42)15-4-2-3-14(27)10-15)16-6-5-13(9-18(16)36-12-20(23)38)24(29,25(30,31)32)26(33,34)35/h2-6,9-10,17,19-20,36H,7-8,11-12H2,1H3/t17-,19-,20?,23?/m0/s1 RXUZMAZHAXJPIV-CRJYNEJLSA-N 382802 US10273259, Example 513::US10273259, Example 522::US10711020, Example 522 Nuclear receptor ROR-gamma Mus musculus 18.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382802&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995603 404852144 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765422 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O6S2/c27-16-2-4-17(5-3-16)44(41,42)23-7-10-36(21(37)22(38)8-11-43(39,40)12-9-22)20(23)14-35-19-13-15(1-6-18(19)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,20,35,38H,7-12,14H2 JVTKTQZHQLEDDU-UHFFFAOYSA-N 382812 US10273259, Example 523::US10711020, Example 523 Nuclear receptor ROR-gamma Mus musculus 45.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382812&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678807 404852153 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765423 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H26ClF7N2O5S/c29-18-6-8-19(9-7-18)44(42,43)25-11-12-38(23(39)15-1-3-16(4-2-15)24(40)41)22(25)14-37-21-13-17(5-10-20(21)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22,37H,1-4,11-12,14H2,(H,40,41)/t15-,16-,22?,25? SWBVPOIJKDRFCY-QAXNPQHNSA-N 382813 US10273259, Example 524::US10711020, Example 524 Nuclear receptor ROR-gamma Mus musculus 71.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382813&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679055 404852154 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765424 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma Mus musculus 319 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765425 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma Mus musculus 98.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765426 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma Mus musculus 398 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765427 OC(=O)C1CCC(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-11-12-37(23(38)16-1-2-17(13-16)24(39)40)22(25)10-3-15-14-18(4-9-21(15)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,16-17,22H,1-3,10-13H2,(H,39,40)/t16?,17?,22-,25-/m1/s1 XRRXYBCURUVMRW-AZNPCEPYSA-N 382699 US10273259, Example 408::US10273259, Example 525::US10273259, Example 526::US10273259, Example 527::US10273259, Example 528::US10711020, Example 528 Nuclear receptor ROR-gamma Mus musculus 225 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382699&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678527 404852047 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765428 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@H]1CCCC(=O)N1 InChI=1S/C27H24F8N2O4S/c28-17-6-8-18(9-7-17)42(40,41)24-12-13-37(23(39)20-2-1-3-22(38)36-20)21(24)11-4-15-14-16(5-10-19(15)24)25(29,26(30,31)32)27(33,34)35/h5-10,14,20-21H,1-4,11-13H2,(H,36,38)/t20-,21+,24+/m0/s1 YWYKJGNVVRTMPM-YZUZCNPQSA-N 382818 US10273259, Example 529::US10711020, Example 529 Nuclear receptor ROR-gamma Mus musculus 199 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382818&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679052 404852155 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765429 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCc2cncn2C1 InChI=1S/C30H27F8N3O3S/c1-17-12-22(6-8-24(17)31)45(43,44)27-10-11-41(26(42)19-2-5-21-14-39-16-40(21)15-19)25(27)9-3-18-13-20(4-7-23(18)27)28(32,29(33,34)35)30(36,37)38/h4,6-8,12-14,16,19,25H,2-3,5,9-11,15H2,1H3 YYFZFMGYDXVYSC-UHFFFAOYSA-N 382819 US10273259, Example 530::US10711020, Example 530 Nuclear receptor ROR-gamma Mus musculus 195 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382819&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679187 404852156 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765430 Cc1cc(ccc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO6S2/c1-16-14-19(4-6-21(16)29)45(42,43)25-8-11-37(23(38)24(39)9-12-44(40,41)13-10-24)22(25)7-2-17-15-18(3-5-20(17)25)26(30,27(31,32)33)28(34,35)36/h3-6,14-15,22,39H,2,7-13H2,1H3 IXWIZXVKHKHMQW-UHFFFAOYSA-N 382820 US10273259, Example 531::US10711020, Example 531 Nuclear receptor ROR-gamma Mus musculus 3665 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382820&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995604 404852157 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765431 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)c(C)c1 InChI=1S/C28H25F9N2O4S/c1-14-11-17(5-7-19(14)29)44(42,43)25-9-10-39(24(41)21-13-20(30)23(40)38(21)2)22(25)8-3-15-12-16(4-6-18(15)25)26(31,27(32,33)34)28(35,36)37/h4-7,11-12,20-22H,3,8-10,13H2,1-2H3/t20-,21-,22?,25?/m0/s1 NOEIOULRAQWJSY-GFOXRHNOSA-N 382821 US10273259, Example 532::US10711020, Example 532 Nuclear receptor ROR-gamma Mus musculus 300 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382821&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995605 404852158 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765432 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCc2cncn2C1 InChI=1S/C29H25F8N3O3S/c30-20-4-7-22(8-5-20)44(42,43)26-11-12-40(25(41)18-1-6-21-14-38-16-39(21)15-18)24(26)10-2-17-13-19(3-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h3-5,7-9,13-14,16,18,24H,1-2,6,10-12,15H2/t18?,24-,26-/m1/s1 SQFZAZHMXJWPGC-DLJUAZHHSA-N 382822 US10273259, Example 533::US10711020, Example 533 Nuclear receptor ROR-gamma Mus musculus 229 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382822&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678980 404852159 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765433 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCc3cncn3C2)c1)C(F)(F)F InChI=1S/C29H25ClF7N3O3S/c30-20-4-7-22(8-5-20)44(42,43)26-11-12-40(25(41)18-1-6-21-14-38-16-39(21)15-18)24(26)10-2-17-13-19(3-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h3-5,7-9,13-14,16,18,24H,1-2,6,10-12,15H2 RIDYVJBZVCYZAI-UHFFFAOYSA-N 382823 US10273259, Example 534::US10711020, Example 534 Nuclear receptor ROR-gamma Mus musculus 171 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382823&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123681 404852160 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765434 FC(F)(F)C(F)(c1ccc2c(NCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H24ClF7N2O5S2/c27-17-2-4-18(5-3-17)43(40,41)23-9-10-36(22(37)15-7-11-42(38,39)12-8-15)21(23)14-35-20-13-16(1-6-19(20)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21,35H,7-12,14H2 OECAWTKNBIXUDZ-UHFFFAOYSA-N 382824 US10273259, Example 535::US10711020, Example 535 Nuclear receptor ROR-gamma Mus musculus 255 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382824&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679226 404852161 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765435 Fc1ccc(cc1F)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H24F9NO5S2/c28-20-5-3-18(14-21(20)29)44(41,42)24-9-10-37(23(38)15-7-11-43(39,40)12-8-15)22(24)6-1-16-13-17(2-4-19(16)24)25(30,26(31,32)33)27(34,35)36/h2-5,13-15,22H,1,6-12H2 KSCQGPXLTGZRQC-UHFFFAOYSA-N 382825 US10273259, Example 536::US10711020, Example 536 Nuclear receptor ROR-gamma Mus musculus 126 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382825&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678708 404852162 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765436 CN1C(CCCC1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O4S/c1-37-21(3-2-4-23(37)39)24(40)38-14-13-25(43(41,42)19-9-7-18(29)8-10-19)20-11-6-17(15-16(20)5-12-22(25)38)26(30,27(31,32)33)28(34,35)36/h6-11,15,21-22H,2-5,12-14H2,1H3/t21?,22-,25-/m1/s1 MFQXWARSIFLBTN-HIAQKOENSA-N 382826 US10273259, Example 537 Nuclear receptor ROR-gamma Mus musculus 242 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382826&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995606 404852163 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765437 OC1(CCS(=O)(=O)CC1)C(=O)N1CCC2(C1CNc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C26H24ClF7N2O6S2/c27-16-2-4-17(5-3-16)44(41,42)23-7-10-36(21(37)22(38)8-11-43(39,40)12-9-22)20(23)14-35-19-13-15(1-6-18(19)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,20,35,38H,7-12,14H2 TXAUZPGQEKMCER-UHFFFAOYSA-N 382827 US10273259, Example 538::US10711020, Example 538 Nuclear receptor ROR-gamma Mus musculus 493 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382827&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679157 404852164 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765438 FC(F)(F)C(F)(c1ccc2c(CC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C26H23ClF7NO5S2/c27-18-2-4-19(5-3-18)42(39,40)23-9-10-35(22(36)15-7-11-41(37,38)12-8-15)21(23)14-16-13-17(1-6-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 AIPFWJCSQFWTFH-UHFFFAOYSA-N 382828 US10273259, Example 539::US10711020, Example 539 Nuclear receptor ROR-gamma Mus musculus 197 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382828&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679024 404852165 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765439 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H25ClF7NO5S/c29-19-6-8-20(9-7-19)43(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-17-13-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? POHKWRAGFPBKAK-QAXNPQHNSA-N 382829 US10273259, Example 540::US10711020, Example 540 Nuclear receptor ROR-gamma Mus musculus 251 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382829&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679225 404852166 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765440 CC(C)(O)CC(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C25H23ClF7NO4S/c1-21(2,36)13-20(35)34-10-9-22(39(37,38)17-6-4-16(26)5-7-17)18-8-3-15(11-14(18)12-19(22)34)23(27,24(28,29)30)25(31,32)33/h3-8,11,19,36H,9-10,12-13H2,1-2H3 BWQBUMBPZBLPPD-UHFFFAOYSA-N 382830 US10273259, Example 541::US10711020, Example 541 Nuclear receptor ROR-gamma Mus musculus 93.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382830&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679201 404852167 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765441 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H25ClF7NO6S/c29-18-2-4-19(5-3-18)44(42,43)25-11-12-37(23(40)24(41)9-7-15(8-10-24)22(38)39)21(25)14-16-13-17(1-6-20(16)25)26(30,27(31,32)33)28(34,35)36/h1-6,13,15,21,41H,7-12,14H2,(H,38,39)/t15-,21?,24+,25? RXNKBJPLEKIJDK-DNNXONSASA-N 382831 US10273259, Example 542::US10711020, Example 542 Nuclear receptor ROR-gamma Mus musculus 74.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382831&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679027 404852168 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765442 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H27ClF7NO5S/c1-25(10-8-16(9-11-25)23(39)40)24(41)38-13-12-26(44(42,43)20-5-3-19(30)4-6-20)21-7-2-18(14-17(21)15-22(26)38)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22H,8-13,15H2,1H3,(H,39,40)/t16-,22?,25-,26? QEFRQORVGXHVSQ-FVSSTLBOSA-N 382832 US10273259, Example 543::US10711020, Example 543 Nuclear receptor ROR-gamma Mus musculus 29.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382832&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678689 404852169 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765443 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C30H27ClF7NO5S/c31-19-2-4-20(5-3-19)45(43,44)27-13-14-39(23(40)25-7-10-26(11-8-25,12-9-25)24(41)42)22(27)16-17-15-18(1-6-21(17)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22H,7-14,16H2,(H,41,42) XPOIVGVPIRPYLP-UHFFFAOYSA-N 382833 US10273259, Example 544::US10711020, Example 544 Nuclear receptor ROR-gamma Mus musculus 714 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382833&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679205 404852170 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765444 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H24ClF8NO5S/c29-18-2-4-19(5-3-18)44(42,43)25-11-12-38(23(41)24(30)9-7-15(8-10-24)22(39)40)21(25)14-16-13-17(1-6-20(16)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21H,7-12,14H2,(H,39,40)/t15-,21?,24+,25? FSBPPGBHNXUWQC-DNNXONSASA-N 382834 US10273259, Example 545::US10711020, Example 545 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382834&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678987 404852171 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765445 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H23F8NO5S2/c27-18-2-4-19(5-3-18)42(39,40)23-9-10-35(22(36)15-7-11-41(37,38)12-8-15)21(23)14-16-13-17(1-6-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 RWBIIUWUMKJGDR-UHFFFAOYSA-N 382835 US10273259, Example 546::US10273259, Example 547::US10711020, Example 547 Nuclear receptor ROR-gamma Mus musculus 105 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382835&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678811 404852172 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765446 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C26H23F8NO5S2/c27-18-2-4-19(5-3-18)42(39,40)23-9-10-35(22(36)15-7-11-41(37,38)12-8-15)21(23)14-16-13-17(1-6-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2 RWBIIUWUMKJGDR-UHFFFAOYSA-N 382835 US10273259, Example 546::US10273259, Example 547::US10711020, Example 547 Nuclear receptor ROR-gamma Mus musculus 9193 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382835&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678811 404852172 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765447 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H22F8N2O4S/c1-35-19(8-9-21(35)37)22(38)36-11-10-23(41(39,40)17-5-3-16(27)4-6-17)18-7-2-15(12-14(18)13-20(23)36)24(28,25(29,30)31)26(32,33)34/h2-7,12,19-20H,8-11,13H2,1H3/t19-,20?,23?/m0/s1 SLLNCMQNYXQVBT-UDTLNKQYSA-N 382837 US10273259, Example 548::US10711020, Example 548 Nuclear receptor ROR-gamma Mus musculus 336 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382837&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678815 404852173 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765448 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-6-8-20(9-7-19)43(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-17-13-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? VALNASKGFRMDLH-QAXNPQHNSA-N 382838 US10273259, Example 549::US10273259, Example 553::US10711020, Example 553 Nuclear receptor ROR-gamma Mus musculus 7576 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382838&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678650 404852174 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765449 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO5S/c1-25(10-8-16(9-11-25)23(39)40)24(41)38-13-12-26(44(42,43)20-5-3-19(30)4-6-20)21-7-2-18(14-17(21)15-22(26)38)27(31,28(32,33)34)29(35,36)37/h2-7,14,16,22H,8-13,15H2,1H3,(H,39,40)/t16-,22?,25-,26? CPIJEWHFOPRYSI-FVSSTLBOSA-N 382839 US10273259, Example 550::US10711020, Example 550 Nuclear receptor ROR-gamma Mus musculus 178 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382839&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679041 404852175 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765450 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO5S/c31-19-2-4-20(5-3-19)45(43,44)27-13-14-39(23(40)25-7-10-26(11-8-25,12-9-25)24(41)42)22(27)16-17-15-18(1-6-21(17)27)28(32,29(33,34)35)30(36,37)38/h1-6,15,22H,7-14,16H2,(H,41,42) WRSSACMQTFMXGA-UHFFFAOYSA-N 382840 US10273259, Example 551::US10711020, Example 551 Nuclear receptor ROR-gamma Mus musculus 166 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382840&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679034 404852176 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765451 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H24F9NO5S/c29-18-2-4-19(5-3-18)44(42,43)25-11-12-38(23(41)24(30)9-7-15(8-10-24)22(39)40)21(25)14-16-13-17(1-6-20(16)25)26(31,27(32,33)34)28(35,36)37/h1-6,13,15,21H,7-12,14H2,(H,39,40)/t15-,21?,24+,25? RDEAWAIHQGSACB-DNNXONSASA-N 382841 US10273259, Example 552::US10711020, Example 552 Nuclear receptor ROR-gamma Mus musculus 42.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382841&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678714 404852177 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765452 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-6-8-20(9-7-19)43(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-17-13-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h5-10,13,15-16,22H,1-4,11-12,14H2,(H,39,40)/t15-,16-,22?,25? VALNASKGFRMDLH-QAXNPQHNSA-N 382838 US10273259, Example 549::US10273259, Example 553::US10711020, Example 553 Nuclear receptor ROR-gamma Mus musculus 76.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382838&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678650 404852174 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765453 OC(=O)c1ccc(cc1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H19F8NO5S/c29-19-6-8-20(9-7-19)43(41,42)25-11-12-37(23(38)15-1-3-16(4-2-15)24(39)40)22(25)14-17-13-18(5-10-21(17)25)26(30,27(31,32)33)28(34,35)36/h1-10,13,22H,11-12,14H2,(H,39,40) TZPLVYMZLXMNQQ-UHFFFAOYSA-N 382843 US10273259, Example 554::US10711020, Example 554 Nuclear receptor ROR-gamma Mus musculus 168 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382843&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678512 404852178 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765454 OC(=O)c1cccc(c1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H19F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-10-11-37(23(38)15-2-1-3-16(12-15)24(39)40)22(25)14-17-13-18(4-9-21(17)25)26(30,27(31,32)33)28(34,35)36/h1-9,12-13,22H,10-11,14H2,(H,39,40) RSUAUWSZMQWICK-UHFFFAOYSA-N 382844 US10273259, Example 555::US10711020, Example 555 Nuclear receptor ROR-gamma Mus musculus 595 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382844&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679196 404852179 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765455 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO6S/c29-18-2-4-19(5-3-18)44(42,43)25-11-12-37(23(40)24(41)9-7-15(8-10-24)22(38)39)21(25)14-16-13-17(1-6-20(16)25)26(30,27(31,32)33)28(34,35)36/h1-6,13,15,21,41H,7-12,14H2,(H,38,39)/t15-,21?,24+,25? ADHKWPQXUQOMGM-DNNXONSASA-N 382845 US10273259, Example 556::US10711020, Example 556 Nuclear receptor ROR-gamma Mus musculus 86.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382845&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679046 404852180 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765456 COc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@@]1(O)CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F7NO7S/c1-44-19-3-5-20(6-4-19)45(42,43)26-12-13-37(24(40)25(41)10-8-16(9-11-25)23(38)39)22(26)15-17-14-18(2-7-21(17)26)27(30,28(31,32)33)29(34,35)36/h2-7,14,16,22,41H,8-13,15H2,1H3,(H,38,39)/t16-,22?,25+,26? XJLNWPBBVORJRT-VXBFRIGJSA-N 382846 US10273259, Example 557::US10711020, Example 557 Nuclear receptor ROR-gamma Mus musculus 128 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382846&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678966 404852181 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765457 OC(=O)C1CCCC(C1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO5S/c29-19-5-7-20(8-6-19)43(41,42)25-10-11-37(23(38)15-2-1-3-16(12-15)24(39)40)22(25)14-17-13-18(4-9-21(17)25)26(30,27(31,32)33)28(34,35)36/h4-9,13,15-16,22H,1-3,10-12,14H2,(H,39,40) JJYPRJNCBPLVBA-UHFFFAOYSA-N 382847 US10273259, Example 558::US10711020, Example 558 Nuclear receptor ROR-gamma Mus musculus 7982 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382847&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679120 404852182 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765458 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO5S/c30-19-2-4-20(5-3-19)44(42,43)26-7-8-38(23(39)16-11-25(12-16)13-17(14-25)24(40)41)22(26)10-15-9-18(1-6-21(15)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,16-17,22H,7-8,10-14H2,(H,40,41) VDNKHLCSDNEVRB-UHFFFAOYSA-N 382848 US10273259, Example 559::US10711020, Example 560 Nuclear receptor ROR-gamma Mus musculus 1006 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382848&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678713 404852183 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765459 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H25F8NO5S/c30-19-2-4-20(5-3-19)44(42,43)26-7-8-38(23(39)16-11-25(12-16)13-17(14-25)24(40)41)22(26)10-15-9-18(1-6-21(15)26)27(31,28(32,33)34)29(35,36)37/h1-6,9,16-17,22H,7-8,10-14H2,(H,40,41) VDNKHLCSDNEVRB-UHFFFAOYSA-N 382849 US10273259, Example 560 Nuclear receptor ROR-gamma Mus musculus 82.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382849&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678713 404852184 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765460 CC1(C)C2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H28F9NO5S/c1-25(2)21-15-17(28(33,29(34,35)36)30(37,38)39)3-8-20(21)27(46(44,45)19-6-4-18(31)5-7-19)13-14-40(23(25)27)24(43)26(32)11-9-16(10-12-26)22(41)42/h3-8,15-16,23H,9-14H2,1-2H3,(H,41,42)/t16-,23?,26+,27? XKICQBGVVZTRCV-ANAVBAIVSA-N 382850 US10273259, Example 561::US10711020, Example 561 Nuclear receptor ROR-gamma Mus musculus 110 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382850&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679007 404852185 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765461 CC1(C)C2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-24(2)21-15-17(26(30,27(31,32)33)28(34,35)36)3-8-20(21)25(44(41,42)19-6-4-18(29)5-7-19)11-12-37(23(24)25)22(38)16-9-13-43(39,40)14-10-16/h3-8,15-16,23H,9-14H2,1-2H3 GRAVAHPUFHJPGH-UHFFFAOYSA-N 382851 US10273259, Example 562::US10711020, Example 562 Nuclear receptor ROR-gamma Mus musculus 224 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382851&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679216 404852186 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765462 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccccc1C#N InChI=1S/C29H20F8N2O3S/c30-21-6-8-22(9-7-21)43(41,42)26-11-12-39(25(40)15-17-3-1-2-4-18(17)16-38)24(26)14-19-13-20(5-10-23(19)26)27(31,28(32,33)34)29(35,36)37/h1-10,13,24H,11-12,14-15H2 AJCXGQPAQMDLGM-UHFFFAOYSA-N 382852 US10273259, Example 563::US10711020, Example 563 Nuclear receptor ROR-gamma Mus musculus 1935 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382852&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679227 404852187 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765463 CCNS(=O)(=O)CCC(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O5S2/c1-2-34-41(37,38)12-9-21(36)35-11-10-22(42(39,40)18-6-4-17(26)5-7-18)19-8-3-16(13-15(19)14-20(22)35)23(27,24(28,29)30)25(31,32)33/h3-8,13,20,34H,2,9-12,14H2,1H3 FVNMJXGMWNHCBH-UHFFFAOYSA-N 382853 US10273259, Example 564::US10711020, Example 564 Nuclear receptor ROR-gamma Mus musculus 275 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382853&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679059 404852188 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765464 CC(Nc1ccc(cc1)C#N)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H23F8N3O3S/c1-17(40-22-7-2-18(16-39)3-8-22)26(42)41-13-12-27(45(43,44)23-9-5-21(31)6-10-23)24-11-4-20(14-19(24)15-25(27)41)28(32,29(33,34)35)30(36,37)38/h2-11,14,17,25,40H,12-13,15H2,1H3 URPAEKJNTHENFO-UHFFFAOYSA-N 382854 US10273259, Example 565::US10273259, Example 566::US10711020, Example 566 Nuclear receptor ROR-gamma Mus musculus 123 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382854&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678722 404852189 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765465 CC(Nc1ccc(cc1)C#N)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H23F8N3O3S/c1-17(40-22-7-2-18(16-39)3-8-22)26(42)41-13-12-27(45(43,44)23-9-5-21(31)6-10-23)24-11-4-20(14-19(24)15-25(27)41)28(32,29(33,34)35)30(36,37)38/h2-11,14,17,25,40H,12-13,15H2,1H3 URPAEKJNTHENFO-UHFFFAOYSA-N 382854 US10273259, Example 565::US10273259, Example 566::US10711020, Example 566 Nuclear receptor ROR-gamma Mus musculus 643 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382854&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678722 404852189 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765466 Cc1cc(cc(C)n1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H22F8N2O3S/c1-15-11-18(12-16(2)37-15)24(39)38-10-9-25(42(40,41)21-6-4-20(29)5-7-21)22-8-3-19(13-17(22)14-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,11-13,23H,9-10,14H2,1-2H3 VBVQNSWSDZMDLS-UHFFFAOYSA-N 382856 US10273259, Example 567::US10711020, Example 567 Nuclear receptor ROR-gamma Mus musculus 444 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382856&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678831 404852190 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765467 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC1c1ccccc1 InChI=1S/C30H23F8NO3S/c31-20-7-9-21(10-8-20)43(41,42)27-12-13-39(26(40)23-16-22(23)17-4-2-1-3-5-17)25(27)15-18-14-19(6-11-24(18)27)28(32,29(33,34)35)30(36,37)38/h1-11,14,22-23,25H,12-13,15-16H2 SMTZSATXSUPHTC-UHFFFAOYSA-N 382857 US10273259, Example 568::US10273259, Example 569::US10711020, Example 569 Nuclear receptor ROR-gamma Mus musculus 489 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382857&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679045 404852191 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765468 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CC1c1ccccc1 InChI=1S/C30H23F8NO3S/c31-20-7-9-21(10-8-20)43(41,42)27-12-13-39(26(40)23-16-22(23)17-4-2-1-3-5-17)25(27)15-18-14-19(6-11-24(18)27)28(32,29(33,34)35)30(36,37)38/h1-11,14,22-23,25H,12-13,15-16H2 SMTZSATXSUPHTC-UHFFFAOYSA-N 382857 US10273259, Example 568::US10273259, Example 569::US10711020, Example 569 Nuclear receptor ROR-gamma Mus musculus 47.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382857&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679045 404852191 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765469 CC(=O)Nc1cccc(c1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H22F8N2O4S/c1-16(40)38-21-4-2-3-17(14-21)25(41)39-12-11-26(44(42,43)22-8-6-20(30)7-9-22)23-10-5-19(13-18(23)15-24(26)39)27(31,28(32,33)34)29(35,36)37/h2-10,13-14,24H,11-12,15H2,1H3,(H,38,40) CDIINHLMLXPNHA-UHFFFAOYSA-N 382859 US10273259, Example 570::US10711020, Example 570 Nuclear receptor ROR-gamma Mus musculus 596 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382859&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678822 404852192 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765470 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CNC(=O)c2ccccc12 InChI=1S/C30H22F8N2O4S/c31-18-6-8-19(9-7-18)45(43,44)27-11-12-40(26(42)22-15-39-25(41)21-4-2-1-3-20(21)22)24(27)14-16-13-17(5-10-23(16)27)28(32,29(33,34)35)30(36,37)38/h1-10,13,22,24H,11-12,14-15H2,(H,39,41) UFCRCOBINSFZRO-UHFFFAOYSA-N 382860 US10273259, Example 571::US10273259, Example 572::US10711020, Example 572 Nuclear receptor ROR-gamma Mus musculus 1352 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382860&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678726 404852193 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765471 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CNC(=O)c2ccccc12 InChI=1S/C30H22F8N2O4S/c31-18-6-8-19(9-7-18)45(43,44)27-11-12-40(26(42)22-15-39-25(41)21-4-2-1-3-20(21)22)24(27)14-16-13-17(5-10-23(16)27)28(32,29(33,34)35)30(36,37)38/h1-10,13,22,24H,11-12,14-15H2,(H,39,41) UFCRCOBINSFZRO-UHFFFAOYSA-N 382860 US10273259, Example 571::US10273259, Example 572::US10711020, Example 572 Nuclear receptor ROR-gamma Mus musculus 5920 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382860&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678726 404852193 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765472 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccc2OCC(=O)Nc2c1 InChI=1S/C29H20F8N2O5S/c30-18-3-5-19(6-4-18)45(42,43)26-9-10-39(25(41)15-1-8-22-21(12-15)38-24(40)14-44-22)23(26)13-16-11-17(2-7-20(16)26)27(31,28(32,33)34)29(35,36)37/h1-8,11-12,23H,9-10,13-14H2,(H,38,40) BECOAWDHXQABCM-UHFFFAOYSA-N 382862 US10273259, Example 573::US10711020, Example 573 Nuclear receptor ROR-gamma Mus musculus 1393 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382862&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679237 404852194 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765473 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cccc(c1)-c1ncn[nH]1 382863 US10273259, Example 574::US10711020, Example 574 Nuclear receptor ROR-gamma Mus musculus 384 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382863&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678723 404852195 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765474 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc(F)cc(c1)C#N InChI=1S/C28H17F9N2O3S/c29-19-2-4-21(5-3-19)43(41,42)25-7-8-39(24(40)17-9-15(14-38)10-20(30)12-17)23(25)13-16-11-18(1-6-22(16)25)26(31,27(32,33)34)28(35,36)37/h1-6,9-12,23H,7-8,13H2 CXDLLHCOPZQYBX-UHFFFAOYSA-N 382864 US10273259, Example 575::US10711020, Example 575 Nuclear receptor ROR-gamma Mus musculus 416 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382864&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679212 404852196 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765475 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc2ccncc2[nH]1 382865 US10273259, Example 576::US10711020, Example 576 Nuclear receptor ROR-gamma Mus musculus 273 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382865&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679197 404852197 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765476 OC12CCCC(CCC1)(C2)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO4S/c31-20-4-6-21(7-5-20)44(42,43)27-13-14-39(24(40)25-9-1-11-26(41,17-25)12-2-10-25)23(27)16-18-15-19(3-8-22(18)27)28(32,29(33,34)35)30(36,37)38/h3-8,15,23,41H,1-2,9-14,16-17H2 RLAOLSNYIGONHT-UHFFFAOYSA-N 382866 US10273259, Example 577::US10711020, Example 577 Nuclear receptor ROR-gamma Mus musculus 11.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382866&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678727 404852198 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765477 CN(C(C)=O)c1ccc(cc1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H24F8N2O4S/c1-17(41)39(2)22-8-3-18(4-9-22)26(42)40-14-13-27(45(43,44)23-10-6-21(31)7-11-23)24-12-5-20(15-19(24)16-25(27)40)28(32,29(33,34)35)30(36,37)38/h3-12,15,25H,13-14,16H2,1-2H3 OVSFXGUMHVFWRA-UHFFFAOYSA-N 382867 US10273259, Example 578::US10711020, Example 578 Nuclear receptor ROR-gamma Mus musculus 4563 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382867&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678922 404852199 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765478 CC1(C)C2CN(CC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-24(2)21-13-17(26(30,27(31,32)33)28(34,35)36)3-8-20(21)25(44(41,42)19-6-4-18(29)5-7-19)15-37(14-22(24)25)23(38)16-9-11-43(39,40)12-10-16/h3-8,13,16,22H,9-12,14-15H2,1-2H3 QHHAKOGJKXHIIF-UHFFFAOYSA-N 382868 US10273259, Example 579::US10273259, Example 580::US10711020, Example 580 Nuclear receptor ROR-gamma Mus musculus 108 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382868&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678806 404852200 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765479 CC1(C)C2CN(CC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H27F8NO5S2/c1-24(2)21-13-17(26(30,27(31,32)33)28(34,35)36)3-8-20(21)25(44(41,42)19-6-4-18(29)5-7-19)15-37(14-22(24)25)23(38)16-9-11-43(39,40)12-10-16/h3-8,13,16,22H,9-12,14-15H2,1-2H3 QHHAKOGJKXHIIF-UHFFFAOYSA-N 382868 US10273259, Example 579::US10273259, Example 580::US10711020, Example 580 Nuclear receptor ROR-gamma Mus musculus 1518 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382868&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678806 404852200 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765480 CC1(C)C2CN(CC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-26(2)22-13-18(28(32,29(33,34)35)30(36,37)38)7-12-21(22)27(45(43,44)20-10-8-19(31)9-11-20)15-39(14-23(26)27)24(40)16-3-5-17(6-4-16)25(41)42/h7-13,16-17,23H,3-6,14-15H2,1-2H3,(H,41,42)/t16-,17-,23?,27? HCAKNKPOVRTLII-VMGIOJFMSA-N 382870 US10273259, Example 581::US10273259, Example 582::US10711020, Example 582 Nuclear receptor ROR-gamma Mus musculus 98.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382870&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679063 404852201 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765481 CC1(C)C2CN(CC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F8NO5S/c1-26(2)22-13-18(28(32,29(33,34)35)30(36,37)38)7-12-21(22)27(45(43,44)20-10-8-19(31)9-11-20)15-39(14-23(26)27)24(40)16-3-5-17(6-4-16)25(41)42/h7-13,16-17,23H,3-6,14-15H2,1-2H3,(H,41,42)/t16-,17-,23?,27? HCAKNKPOVRTLII-VMGIOJFMSA-N 382870 US10273259, Example 581::US10273259, Example 582::US10711020, Example 582 Nuclear receptor ROR-gamma Mus musculus 6891 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382870&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679063 404852201 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765482 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CC2Oc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H22F9NO6S/c28-16-2-4-17(5-3-16)44(41,42)24-13-37(22(40)23(29)9-7-14(8-10-23)21(38)39)12-20(24)43-19-11-15(1-6-18(19)24)25(30,26(31,32)33)27(34,35)36/h1-6,11,14,20H,7-10,12-13H2,(H,38,39)/t14-,20?,23+,24? OOWQLVRMCALMNH-ZCVBTQTPSA-N 382872 US10273259, Example 583::US10273259, Example 584::US10711020, Example 584 Nuclear receptor ROR-gamma Mus musculus 2798 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382872&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679215 404852202 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765483 OC(=O)[C@H]1CC[C@@](F)(CC1)C(=O)N1CC2Oc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H22F9NO6S/c28-16-2-4-17(5-3-16)44(41,42)24-13-37(22(40)23(29)9-7-14(8-10-23)21(38)39)12-20(24)43-19-11-15(1-6-18(19)24)25(30,26(31,32)33)27(34,35)36/h1-6,11,14,20H,7-10,12-13H2,(H,38,39)/t14-,20?,23+,24? OOWQLVRMCALMNH-ZCVBTQTPSA-N 382872 US10273259, Example 583::US10273259, Example 584::US10711020, Example 584 Nuclear receptor ROR-gamma Mus musculus 13826 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382872&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679215 404852202 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765484 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1Oc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C25H21F8NO6S2/c26-16-2-4-17(5-3-16)42(38,39)22-13-34(21(35)14-7-9-41(36,37)10-8-14)12-20(22)40-19-11-15(1-6-18(19)22)23(27,24(28,29)30)25(31,32)33/h1-6,11,14,20H,7-10,12-13H2 KSEUAZYMJVUHQG-UHFFFAOYSA-N 382874 US10273259, Example 585::US10711020, Example 585 Nuclear receptor ROR-gamma Mus musculus 8537 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382874&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679186 404852203 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765485 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO5S/c30-21-8-10-22(11-9-21)44(42,43)26-15-38(24(39)16-1-3-17(4-2-16)25(40)41)14-20(26)6-5-18-13-19(7-12-23(18)26)27(31,28(32,33)34)29(35,36)37/h7-13,16-17,20H,1-6,14-15H2,(H,40,41)/t16-,17-,20?,26? RIDQGXYSIJPZIM-OPLQCYDDSA-N 382875 US10273259, Example 586::US10711020, Example 620 Nuclear receptor ROR-gamma Mus musculus 79.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382875&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678656 404852204 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765486 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H29F8NO5S/c32-21-4-6-22(7-5-21)46(44,45)28-17-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)16-20(28)2-1-18-15-19(3-8-23(18)28)29(33,30(34,35)36)31(37,38)39/h3-8,15,20H,1-2,9-14,16-17H2,(H,42,43) RLGGHTPFORLLGC-UHFFFAOYSA-N 382876 US10273259, Example 587::US10273259, Example 621::US10711020, Example 621 Nuclear receptor ROR-gamma Mus musculus 158 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382876&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679213 404852205 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765487 OC(=O)C1CCCC(C1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO5S/c30-21-7-9-22(10-8-21)44(42,43)26-15-38(24(39)17-2-1-3-18(12-17)25(40)41)14-20(26)5-4-16-13-19(6-11-23(16)26)27(31,28(32,33)34)29(35,36)37/h6-11,13,17-18,20H,1-5,12,14-15H2,(H,40,41) RUUOWBOOOXSWOU-UHFFFAOYSA-N 382877 US10273259, Example 588::US10273259, Example 589::US10711020, Example 589 Nuclear receptor ROR-gamma Mus musculus 894 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382877&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123826 404852206 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765488 OC(=O)C1CCCC(C1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO5S/c30-21-7-9-22(10-8-21)44(42,43)26-15-38(24(39)17-2-1-3-18(12-17)25(40)41)14-20(26)5-4-16-13-19(6-11-23(16)26)27(31,28(32,33)34)29(35,36)37/h6-11,13,17-18,20H,1-5,12,14-15H2,(H,40,41) RUUOWBOOOXSWOU-UHFFFAOYSA-N 382877 US10273259, Example 588::US10273259, Example 589::US10711020, Example 589 Nuclear receptor ROR-gamma Mus musculus 771 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382877&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123826 404852206 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765489 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO5S2/c28-20-4-6-21(7-5-20)43(40,41)24-15-36(23(37)16-9-11-42(38,39)12-10-16)14-19(24)2-1-17-13-18(3-8-22(17)24)25(29,26(30,31)32)27(33,34)35/h3-8,13,16,19H,1-2,9-12,14-15H2 BYJQBROKHHUEJL-UHFFFAOYSA-N 382879 US10273259, Example 590::US10711020, Example 590 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382879&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679070 404852207 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765490 CC(C)(O)CC(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H25F8NO4S/c1-22(2,37)12-21(36)35-13-17-4-3-15-11-16(24(28,25(29,30)31)26(32,33)34)5-10-20(15)23(17,14-35)40(38,39)19-8-6-18(27)7-9-19/h5-11,17,37H,3-4,12-14H2,1-2H3 YJQDWWAPVDZSFU-UHFFFAOYSA-N 382880 US10273259, Example 591::US10711020, Example 591 Nuclear receptor ROR-gamma Mus musculus 202 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382880&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678715 404852208 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765491 OC(=O)c1cc(on1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H18F8N2O6S/c27-16-4-6-17(7-5-16)43(40,41)23-12-36(21(37)20-10-19(22(38)39)35-42-20)11-15(23)2-1-13-9-14(3-8-18(13)23)24(28,25(29,30)31)26(32,33)34/h3-10,15H,1-2,11-12H2,(H,38,39) ZHDBIKJGYVNLPR-UHFFFAOYSA-N 382881 US10273259, Example 592::US10711020, Example 592 Nuclear receptor ROR-gamma Mus musculus 145 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382881&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678829 404852209 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765492 OC(=O)c1cnc(cn1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H19F8N3O5S/c28-17-4-6-18(7-5-17)44(42,43)24-13-38(22(39)20-10-37-21(11-36-20)23(40)41)12-16(24)2-1-14-9-15(3-8-19(14)24)25(29,26(30,31)32)27(33,34)35/h3-11,16H,1-2,12-13H2,(H,40,41) CKKIKJALWNCAKN-UHFFFAOYSA-N 382882 US10273259, Example 593::US10711020, Example 593 Nuclear receptor ROR-gamma Mus musculus 130 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382882&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679090 404852210 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765493 OC(=O)c1c[nH]c(c1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F 382883 US10273259, Example 594::US10711020, Example 594 Nuclear receptor ROR-gamma Mus musculus 245 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382883&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679042 404852211 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765494 OC(=O)c1cc([nH]n1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F 382884 US10273259, Example 595::US10711020, Example 595 Nuclear receptor ROR-gamma Mus musculus 825 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382884&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679220 404852212 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765495 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)CC1CC(=O)NC(=O)C1 InChI=1S/C28H24F8N2O5S/c29-19-4-6-20(7-5-19)44(42,43)25-14-38(24(41)11-15-9-22(39)37-23(40)10-15)13-18(25)2-1-16-12-17(3-8-21(16)25)26(30,27(31,32)33)28(34,35)36/h3-8,12,15,18H,1-2,9-11,13-14H2,(H,37,39,40) RATMPLBUFOJCAA-UHFFFAOYSA-N 382885 US10273259, Example 596::US10711020, Example 596 Nuclear receptor ROR-gamma Mus musculus 120 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382885&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679022 404852213 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765496 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cncs1 InChI=1S/C25H18F8N2O3S2/c26-17-4-6-18(7-5-17)40(37,38)22-12-35(21(36)20-10-34-13-39-20)11-16(22)2-1-14-9-15(3-8-19(14)22)23(27,24(28,29)30)25(31,32)33/h3-10,13,16H,1-2,11-12H2 BJMGBJGECLJTNN-UHFFFAOYSA-N 382886 US10273259, Example 597::US10711020, Example 597 Nuclear receptor ROR-gamma Mus musculus 333 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382886&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678690 404852214 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765497 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc(=O)cco1 InChI=1S/C27H19F8NO5S/c28-18-4-6-20(7-5-18)42(39,40)24-14-36(23(38)22-12-19(37)9-10-41-22)13-17(24)2-1-15-11-16(3-8-21(15)24)25(29,26(30,31)32)27(33,34)35/h3-12,17H,1-2,13-14H2 LQHMVONMQMTMHJ-UHFFFAOYSA-N 382887 US10273259, Example 598::US10711020, Example 598 Nuclear receptor ROR-gamma Mus musculus 166 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382887&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679239 404852215 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765498 CCCCC(O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H27F8NO4S/c1-2-3-4-22(37)23(38)36-14-18-6-5-16-13-17(25(29,26(30,31)32)27(33,34)35)7-12-21(16)24(18,15-36)41(39,40)20-10-8-19(28)9-11-20/h7-13,18,22,37H,2-6,14-15H2,1H3 SOSNWIWFFPVBQS-UHFFFAOYSA-N 382888 US10273259, Example 599::US10711020, Example 599 Nuclear receptor ROR-gamma Mus musculus 311 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382888&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679211 404852216 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765499 OC(C1CCCCC1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H29F8NO4S/c30-21-9-11-22(12-10-21)43(41,42)26-16-38(25(40)24(39)17-4-2-1-3-5-17)15-20(26)7-6-18-14-19(8-13-23(18)26)27(31,28(32,33)34)29(35,36)37/h8-14,17,20,24,39H,1-7,15-16H2 FIUZBQCEBITIEI-UHFFFAOYSA-N 382889 US10273259, Example 600 Nuclear receptor ROR-gamma Mus musculus 197 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382889&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679222 404852217 C03491 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765500 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccnnc1 InChI=1S/C26H19F8N3O3S/c27-19-4-6-20(7-5-19)41(39,40)23-14-37(22(38)16-9-10-35-36-12-16)13-18(23)2-1-15-11-17(3-8-21(15)23)24(28,25(29,30)31)26(32,33)34/h3-12,18H,1-2,13-14H2 CPMXAOUPPQMLSP-UHFFFAOYSA-N 382890 US10273259, Example 601::US10711020, Example 601 Nuclear receptor ROR-gamma Mus musculus 231 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382890&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678724 404852218 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765501 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc2cnccc2[nH]1 382891 US10273259, Example 602::US10711020, Example 602 Nuclear receptor ROR-gamma Mus musculus 100.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382891&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679229 404852219 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765502 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1coc2CCCC(=O)c12 InChI=1S/C30H23F8NO5S/c31-19-7-9-20(10-8-19)45(42,43)27-15-39(26(41)21-14-44-24-3-1-2-23(40)25(21)24)13-18(27)5-4-16-12-17(6-11-22(16)27)28(32,29(33,34)35)30(36,37)38/h6-12,14,18H,1-5,13,15H2 DLTFUPQIYFEYJW-UHFFFAOYSA-N 382892 US10273259, Example 603::US10711020, Example 603 Nuclear receptor ROR-gamma Mus musculus 267 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382892&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679188 404852220 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765503 Oc1cc(on1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H18F8N2O5S/c26-16-4-6-17(7-5-16)41(38,39)22-12-35(21(37)19-10-20(36)34-40-19)11-15(22)2-1-13-9-14(3-8-18(13)22)23(27,24(28,29)30)25(31,32)33/h3-10,15H,1-2,11-12H2,(H,34,36) DXGSXIOOHIZPQC-UHFFFAOYSA-N 382893 US10273259, Example 604::US10711020, Example 604 Nuclear receptor ROR-gamma Mus musculus 319 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382893&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678843 404852221 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765504 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cnc[nH]1 382894 US10273259, Example 605::US10711020, Example 605 Nuclear receptor ROR-gamma Mus musculus 397 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382894&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678827 404852222 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765505 Cn1nc2CCCCc2c1C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H27F8N3O3S/c1-40-25(22-4-2-3-5-24(22)39-40)26(42)41-15-19-7-6-17-14-18(28(32,29(33,34)35)30(36,37)38)8-13-23(17)27(19,16-41)45(43,44)21-11-9-20(31)10-12-21/h8-14,19H,2-7,15-16H2,1H3 WKNSUEVQHBMKOU-UHFFFAOYSA-N 382895 US10273259, Example 606::US10711020, Example 606 Nuclear receptor ROR-gamma Mus musculus 244 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382895&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679077 404852223 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765506 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1c[nH]c2nccnc12 382896 US10273259, Example 607::US10711020, Example 607 Nuclear receptor ROR-gamma Mus musculus 342 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382896&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679050 404852224 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765507 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Cc1ccc2ncccc2c1 InChI=1S/C32H24F8N2O3S/c33-24-7-9-25(10-8-24)46(44,45)29-18-42(28(43)15-19-3-12-27-21(14-19)2-1-13-41-27)17-23(29)5-4-20-16-22(6-11-26(20)29)30(34,31(35,36)37)32(38,39)40/h1-3,6-14,16,23H,4-5,15,17-18H2 VBHOROJAAXNQGZ-UHFFFAOYSA-N 382897 US10273259, Example 608::US10711020, Example 608 Nuclear receptor ROR-gamma Mus musculus 286 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382897&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679025 404852225 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765508 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cnc(Cl)s1 InChI=1S/C25H17ClF8N2O3S2/c26-21-35-10-19(40-21)20(37)36-11-15-2-1-13-9-14(23(28,24(29,30)31)25(32,33)34)3-8-18(13)22(15,12-36)41(38,39)17-6-4-16(27)5-7-17/h3-10,15H,1-2,11-12H2 NNIIYHJSKSTVLX-UHFFFAOYSA-N 382898 US10273259, Example 609::US10711020, Example 609 Nuclear receptor ROR-gamma Mus musculus 117 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382898&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679086 404852226 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765509 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1=CCCC1 InChI=1S/C27H23F8NO3S/c28-20-8-10-21(11-9-20)40(38,39)24-15-36(23(37)16-3-1-2-4-16)14-19(24)6-5-17-13-18(7-12-22(17)24)25(29,26(30,31)32)27(33,34)35/h3,7-13,19H,1-2,4-6,14-15H2 DZUXOKIFEXTESF-UHFFFAOYSA-N 382899 US10273259, Example 610::US10711020, Example 610 Nuclear receptor ROR-gamma Mus musculus 185 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382899&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678825 404852227 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765510 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cc[nH]n1 382900 US10273259, Example 611::US10711020, Example 611 Nuclear receptor ROR-gamma Mus musculus 610 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382900&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679245 404852228 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765511 OCC(O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C24H21F8NO5S/c25-16-4-6-17(7-5-16)39(37,38)21-12-33(20(36)19(35)11-34)10-15(21)2-1-13-9-14(3-8-18(13)21)22(26,23(27,28)29)24(30,31)32/h3-9,15,19,34-35H,1-2,10-12H2 JGCCPHHZLYNPHX-UHFFFAOYSA-N 382901 US10273259, Example 612::US10711020, Example 612 Nuclear receptor ROR-gamma Mus musculus 360 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382901&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678824 404852229 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765512 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1cnc(s1)C1OCCO1 InChI=1S/C28H22F8N2O5S2/c29-18-4-6-19(7-5-18)45(40,41)25-14-38(23(39)21-12-37-22(44-21)24-42-9-10-43-24)13-17(25)2-1-15-11-16(3-8-20(15)25)26(30,27(31,32)33)28(34,35)36/h3-8,11-12,17,24H,1-2,9-10,13-14H2 BVYLTFLDGZQHFJ-UHFFFAOYSA-N 382902 US10273259, Example 613::US10711020, Example 613 Nuclear receptor ROR-gamma Mus musculus 660 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382902&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678849 404852230 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765513 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccsc1 InChI=1S/C26H19F8NO3S2/c27-19-4-6-20(7-5-19)40(37,38)23-14-35(22(36)16-9-10-39-13-16)12-18(23)2-1-15-11-17(3-8-21(15)23)24(28,25(29,30)31)26(32,33)34/h3-11,13,18H,1-2,12,14H2 KLJOETHBXLRMBZ-UHFFFAOYSA-N 382903 US10273259, Example 614::US10711020, Example 614 Nuclear receptor ROR-gamma Mus musculus 190 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382903&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679011 404852231 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765514 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccns1 InChI=1S/C25H18F8N2O3S2/c26-17-4-6-18(7-5-17)40(37,38)22-13-35(21(36)20-9-10-34-39-20)12-16(22)2-1-14-11-15(3-8-19(14)22)23(27,24(28,29)30)25(31,32)33/h3-11,16H,1-2,12-13H2 LTOJHNPVNDICSX-UHFFFAOYSA-N 382904 US10273259, Example 615::US10711020, Example 615 Nuclear receptor ROR-gamma Mus musculus 125 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382904&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678861 404852232 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765515 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1Cc2cc(Cl)ccc2N1 InChI=1S/C30H23ClF8N2O3S/c31-20-4-10-24-17(12-20)13-25(40-24)26(42)41-14-19-2-1-16-11-18(28(33,29(34,35)36)30(37,38)39)3-9-23(16)27(19,15-41)45(43,44)22-7-5-21(32)6-8-22/h3-12,19,25,40H,1-2,13-15H2 CKFGGUJEUQVRNT-UHFFFAOYSA-N 382905 US10273259, Example 616::US10711020, Example 616 Nuclear receptor ROR-gamma Mus musculus 1364 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382905&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679073 404852233 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765516 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccno1 InChI=1S/C25H18F8N2O4S/c26-17-4-6-18(7-5-17)40(37,38)22-13-35(21(36)20-9-10-34-39-20)12-16(22)2-1-14-11-15(3-8-19(14)22)23(27,24(28,29)30)25(31,32)33/h3-11,16H,1-2,12-13H2 QOJXPPRKWRSKJP-UHFFFAOYSA-N 382906 US10273259, Example 617::US10711020, Example 617 Nuclear receptor ROR-gamma Mus musculus 192 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382906&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678869 404852234 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765517 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)c1ccon1 InChI=1S/C25H18F8N2O4S/c26-17-4-6-18(7-5-17)40(37,38)22-13-35(21(36)20-9-10-39-34-20)12-16(22)2-1-14-11-15(3-8-19(14)22)23(27,24(28,29)30)25(31,32)33/h3-11,16H,1-2,12-13H2 AEYQRMPASXTBKI-UHFFFAOYSA-N 382907 US10273259, Example 618::US10711020, Example 618 Nuclear receptor ROR-gamma Mus musculus 392 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382907&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679091 404852235 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765518 Fc1ccc(cc1)S(=O)(=O)C12CN(CC1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(CC1)C#N InChI=1S/C26H20F8N2O3S/c27-18-4-6-19(7-5-18)40(38,39)23-14-36(21(37)22(13-35)9-10-22)12-17(23)2-1-15-11-16(3-8-20(15)23)24(28,25(29,30)31)26(32,33)34/h3-8,11,17H,1-2,9-10,12,14H2 FPABLRXQWBFMDY-UHFFFAOYSA-N 382908 US10273259, Example 619::US10711020, Example 619 Nuclear receptor ROR-gamma Mus musculus 271 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382908&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678744 404852236 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765519 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H27F8NO5S/c30-21-8-10-22(11-9-21)44(42,43)26-15-38(24(39)16-1-3-17(4-2-16)25(40)41)14-20(26)6-5-18-13-19(7-12-23(18)26)27(31,28(32,33)34)29(35,36)37/h7-13,16-17,20H,1-6,14-15H2,(H,40,41)/t16-,17-,20?,26? RIDQGXYSIJPZIM-OPLQCYDDSA-N 382909 US10273259, Example 620 Nuclear receptor ROR-gamma Mus musculus 493 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382909&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678656 404852237 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765520 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H29F8NO5S/c32-21-4-6-22(7-5-21)46(44,45)28-17-40(24(41)26-9-12-27(13-10-26,14-11-26)25(42)43)16-20(28)2-1-18-15-19(3-8-23(18)28)29(33,30(34,35)36)31(37,38)39/h3-8,15,20H,1-2,9-14,16-17H2,(H,42,43) RLGGHTPFORLLGC-UHFFFAOYSA-N 382876 US10273259, Example 587::US10273259, Example 621::US10711020, Example 621 Nuclear receptor ROR-gamma Mus musculus 308 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382876&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679213 404852205 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765521 CN1[C@@H](CCC1=O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H24F8N2O4S/c1-36-21(10-11-22(36)38)23(39)37-13-17-3-2-15-12-16(25(29,26(30,31)32)27(33,34)35)4-9-20(15)24(17,14-37)42(40,41)19-7-5-18(28)6-8-19/h4-9,12,17,21H,2-3,10-11,13-14H2,1H3/t17?,21-,24?/m0/s1 VAYFCOIKLQAOOP-LBVATQBMSA-N 382911 US10273259, Example 622::US10711020, Example 622 Nuclear receptor ROR-gamma Mus musculus 4508 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382911&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995607 404852238 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765522 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-20-6-8-21(9-7-20)45(42,43)26-11-12-38(24(39)16-1-3-17(4-2-16)25(40)41)14-19(26)15-44-23-13-18(5-10-22(23)26)27(31,28(32,33)34)29(35,36)37/h5-10,13,16-17,19H,1-4,11-12,14-15H2,(H,40,41)/t16-,17-,19?,26? YUGCFWDORUEUGB-ZFKZCHJLSA-N 382912 US10273259, Example 623::US10273259, Example 634::US10711020, Example 634 Nuclear receptor ROR-gamma Mus musculus 6586 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382912&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678733 404852239 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765523 OC(=O)C1CC2(C1)CC(C2)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H27F8NO6S/c31-20-2-4-21(5-3-20)46(43,44)27-7-8-39(24(40)16-10-26(11-16)12-17(13-26)25(41)42)14-19(27)15-45-23-9-18(1-6-22(23)27)28(32,29(33,34)35)30(36,37)38/h1-6,9,16-17,19H,7-8,10-15H2,(H,41,42) ICDNKYIDWWRWFU-UHFFFAOYSA-N 382913 US10273259, Example 624 Nuclear receptor ROR-gamma Mus musculus 1754 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382913&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679231 404852240 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765524 Fc1ccc(cc1)S(=O)(=O)C12CCN(CC1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO6S2/c28-19-2-4-20(5-3-19)44(40,41)24-9-10-36(23(37)16-7-11-43(38,39)12-8-16)14-18(24)15-42-22-13-17(1-6-21(22)24)25(29,26(30,31)32)27(33,34)35/h1-6,13,16,18H,7-12,14-15H2 GFPRRSCXNWMBBB-UHFFFAOYSA-N 382914 US10273259, Example 625::US10273259, Example 635::US10711020, Example 635 Nuclear receptor ROR-gamma Mus musculus 425 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382914&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679097 404852241 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765525 CC(C)(O)CC(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO5S/c1-22(2,37)12-21(36)35-10-9-23(41(38,39)18-6-4-17(27)5-7-18)16(13-35)14-40-20-11-15(3-8-19(20)23)24(28,25(29,30)31)26(32,33)34/h3-8,11,16,37H,9-10,12-14H2,1-2H3 ZFJLVGNWGHIVHS-UHFFFAOYSA-N 382915 US10273259, Example 626::US10711020, Example 626 Nuclear receptor ROR-gamma Mus musculus 897 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382915&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678838 404852242 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765526 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c1-36-20(8-9-22(36)38)23(39)37-11-10-24(43(40,41)18-5-3-17(28)4-6-18)16(13-37)14-42-21-12-15(2-7-19(21)24)25(29,26(30,31)32)27(33,34)35/h2-7,12,16,20H,8-11,13-14H2,1H3/t16?,20-,24?/m0/s1 ODQPSMWGCHAGSW-XUGLNINTSA-N 382916 US10273259, Example 627::US10273259, Example 628::US10711020, Example 628 Nuclear receptor ROR-gamma Mus musculus 1450 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382916&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678836 404852243 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765527 CN1[C@@H](CCC1=O)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c1-36-20(8-9-22(36)38)23(39)37-11-10-24(43(40,41)18-5-3-17(28)4-6-18)16(13-37)14-42-21-12-15(2-7-19(21)24)25(29,26(30,31)32)27(33,34)35/h2-7,12,16,20H,8-11,13-14H2,1H3/t16?,20-,24?/m0/s1 ODQPSMWGCHAGSW-XUGLNINTSA-N 382916 US10273259, Example 627::US10273259, Example 628::US10711020, Example 628 Nuclear receptor ROR-gamma Mus musculus 744 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382916&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678836 404852243 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765528 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H23F9N2O5S/c1-37-20(11-19(29)22(37)39)23(40)38-9-8-24(44(41,42)17-5-3-16(28)4-6-17)15(12-38)13-43-21-10-14(2-7-18(21)24)25(30,26(31,32)33)27(34,35)36/h2-7,10,15,19-20H,8-9,11-13H2,1H3/t15?,19-,20-,24?/m0/s1 QRCCFITXDNQCMM-ZHALMGHNSA-N 382918 US10273259, Example 629::US10711020, Example 629 Nuclear receptor ROR-gamma Mus musculus 3545 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382918&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995608 404852244 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765529 OC(=O)C1CCCC(C1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-20-5-7-21(8-6-20)45(42,43)26-10-11-38(24(39)16-2-1-3-17(12-16)25(40)41)14-19(26)15-44-23-13-18(4-9-22(23)26)27(31,28(32,33)34)29(35,36)37/h4-9,13,16-17,19H,1-3,10-12,14-15H2,(H,40,41) UJJDMOYKXATPNI-UHFFFAOYSA-N 382919 US10273259, Example 630::US10711020, Example 630 Nuclear receptor ROR-gamma Mus musculus 6753 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382919&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678738 404852245 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765530 OC(=O)C1CCC(C1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H25F8NO6S/c29-19-4-6-20(7-5-19)44(41,42)25-9-10-37(23(38)15-1-2-16(11-15)24(39)40)13-18(25)14-43-22-12-17(3-8-21(22)25)26(30,27(31,32)33)28(34,35)36/h3-8,12,15-16,18H,1-2,9-11,13-14H2,(H,39,40) XHDZXSUWYPVGCI-UHFFFAOYSA-N 382920 US10273259, Example 631::US10711020, Example 631 Nuclear receptor ROR-gamma Mus musculus 1701 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382920&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679089 404852246 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765531 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO6S/c1-26(10-8-17(9-11-26)24(40)41)25(42)39-13-12-27(46(43,44)21-5-3-20(31)4-6-21)19(15-39)16-45-23-14-18(2-7-22(23)27)28(32,29(33,34)35)30(36,37)38/h2-7,14,17,19H,8-13,15-16H2,1H3,(H,40,41)/t17-,19?,26-,27? YSGHQSVQDYLDHX-VRMBQRHRSA-N 382921 US10273259, Example 632::US10711020, Example 632 Nuclear receptor ROR-gamma Mus musculus 5779 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382921&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678741 404852247 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765532 OC(=O)[C@H]1CC[C@@](O)(CC1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO7S/c30-19-2-4-20(5-3-19)46(43,44)26-11-12-38(24(41)25(42)9-7-16(8-10-25)23(39)40)14-18(26)15-45-22-13-17(1-6-21(22)26)27(31,28(32,33)34)29(35,36)37/h1-6,13,16,18,42H,7-12,14-15H2,(H,39,40)/t16-,18?,25+,26? AIHAKTVYKDNOJD-HTHZVERSSA-N 382922 US10273259, Example 633::US10711020, Example 633 Nuclear receptor ROR-gamma Mus musculus 249 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382922&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679094 404852248 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765533 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C(COc3cc(ccc23)C(F)(C(F)(F)F)C(F)(F)F)C1)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c30-20-6-8-21(9-7-20)45(42,43)26-11-12-38(24(39)16-1-3-17(4-2-16)25(40)41)14-19(26)15-44-23-13-18(5-10-22(23)26)27(31,28(32,33)34)29(35,36)37/h5-10,13,16-17,19H,1-4,11-12,14-15H2,(H,40,41)/t16-,17-,19?,26? YUGCFWDORUEUGB-ZFKZCHJLSA-N 382912 US10273259, Example 623::US10273259, Example 634::US10711020, Example 634 Nuclear receptor ROR-gamma Mus musculus 5967 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382912&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678733 404852239 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765534 Fc1ccc(cc1)S(=O)(=O)C12CCN(CC1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H25F8NO6S2/c28-19-2-4-20(5-3-19)44(40,41)24-9-10-36(23(37)16-7-11-43(38,39)12-8-16)14-18(24)15-42-22-13-17(1-6-21(22)24)25(29,26(30,31)32)27(33,34)35/h1-6,13,16,18H,7-12,14-15H2 GFPRRSCXNWMBBB-UHFFFAOYSA-N 382914 US10273259, Example 625::US10273259, Example 635::US10711020, Example 635 Nuclear receptor ROR-gamma Mus musculus 4957 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382914&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679097 404852241 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765535 CCNC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c1-2-33-20(35)34-12-11-21(38(36,37)17-7-5-16(25)6-8-17)18-9-4-15(13-14(18)3-10-19(21)34)22(26,23(27,28)29)24(30,31)32/h4-9,13,19H,2-3,10-12H2,1H3,(H,33,35)/t19-,21-/m1/s1 LKBKHFSEJYFWRW-TZIWHRDSSA-N 382925 (3aR,9bR)—N-ethyl-9b-((4-fluorophenyl)sulfonyl)-7-perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carboxamide::US10273259, Example 636::US10711020, Example 636 Nuclear receptor ROR-gamma Mus musculus 171 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382925&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669211 404852249 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765536 CC1CN(CCC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-16-15-38(12-10-21(16)24(40)41)25(42)39-13-11-26(45(43,44)20-6-4-19(30)5-7-20)22-8-3-18(14-17(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,14,16,21,23H,2,9-13,15H2,1H3,(H,40,41)/t16?,21?,23-,26-/m1/s1 JHUZNZHWSOZRLD-AAPRQYKCSA-N 382926 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylpiperidine-4-carboxylic acid::US10273259, Example 637::US10273259, Example 638::US10273259, Example 639::US10273259, Example 640::US10711020, Example 640 Nuclear receptor ROR-gamma Mus musculus 92.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382926&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669143 404852250 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765537 CC1CN(CCC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-16-15-38(12-10-21(16)24(40)41)25(42)39-13-11-26(45(43,44)20-6-4-19(30)5-7-20)22-8-3-18(14-17(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,14,16,21,23H,2,9-13,15H2,1H3,(H,40,41)/t16?,21?,23-,26-/m1/s1 JHUZNZHWSOZRLD-AAPRQYKCSA-N 382926 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylpiperidine-4-carboxylic acid::US10273259, Example 637::US10273259, Example 638::US10273259, Example 639::US10273259, Example 640::US10711020, Example 640 Nuclear receptor ROR-gamma Mus musculus 70.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382926&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669143 404852250 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765538 CC1CN(CCC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-16-15-38(12-10-21(16)24(40)41)25(42)39-13-11-26(45(43,44)20-6-4-19(30)5-7-20)22-8-3-18(14-17(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,14,16,21,23H,2,9-13,15H2,1H3,(H,40,41)/t16?,21?,23-,26-/m1/s1 JHUZNZHWSOZRLD-AAPRQYKCSA-N 382926 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylpiperidine-4-carboxylic acid::US10273259, Example 637::US10273259, Example 638::US10273259, Example 639::US10273259, Example 640::US10711020, Example 640 Nuclear receptor ROR-gamma Mus musculus 23.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382926&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669143 404852250 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765539 CC1CN(CCC1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-16-15-38(12-10-21(16)24(40)41)25(42)39-13-11-26(45(43,44)20-6-4-19(30)5-7-20)22-8-3-18(14-17(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,14,16,21,23H,2,9-13,15H2,1H3,(H,40,41)/t16?,21?,23-,26-/m1/s1 JHUZNZHWSOZRLD-AAPRQYKCSA-N 382926 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylpiperidine-4-carboxylic acid::US10273259, Example 637::US10273259, Example 638::US10273259, Example 639::US10273259, Example 640::US10711020, Example 640 Nuclear receptor ROR-gamma Mus musculus 51.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382926&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669143 404852250 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765540 CC1CN(CCC1C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O6S/c1-15-13-37(10-8-19(15)23(39)40)24(41)38-11-9-25(45(42,43)18-5-3-17(29)4-6-18)20-7-2-16(12-21(20)44-14-22(25)38)26(30,27(31,32)33)28(34,35)36/h2-7,12,15,19,22H,8-11,13-14H2,1H3,(H,39,40) DMJJKCSHNFWGGD-UHFFFAOYSA-N 382930 US10273259, Example 641::US10273259, Example 642::US10711020, Example 642 Nuclear receptor ROR-gamma Mus musculus 83.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382930&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678862 404852251 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765541 CC1CN(CCC1C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O6S/c1-15-13-37(10-8-19(15)23(39)40)24(41)38-11-9-25(45(42,43)18-5-3-17(29)4-6-18)20-7-2-16(12-21(20)44-14-22(25)38)26(30,27(31,32)33)28(34,35)36/h2-7,12,15,19,22H,8-11,13-14H2,1H3,(H,39,40) DMJJKCSHNFWGGD-UHFFFAOYSA-N 382930 US10273259, Example 641::US10273259, Example 642::US10711020, Example 642 Nuclear receptor ROR-gamma Mus musculus 156 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382930&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678862 404852251 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765542 OC(=O)C1(O)CCN(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O6S/c29-18-3-5-19(6-4-18)45(43,44)25-11-14-38(23(41)37-12-9-24(42,10-13-37)22(39)40)21(25)8-1-16-15-17(2-7-20(16)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,21,42H,1,8-14H2,(H,39,40)/t21-,25-/m1/s1 IWVANVDDDFZNAS-PXDATVDWSA-N 382932 US10273259, Example 643::US10711020, Example 643 Nuclear receptor ROR-gamma Mus musculus 161 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382932&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678877 404852252 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765543 CC(=O)N1CCN(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H27F8N3O4S/c1-17(40)37-12-14-38(15-13-37)24(41)39-11-10-25(44(42,43)21-6-4-20(29)5-7-21)22-8-3-19(16-18(22)2-9-23(25)39)26(30,27(31,32)33)28(34,35)36/h3-8,16,23H,2,9-15H2,1H3/t23-,25-/m1/s1 MDBGAUFKHOOREB-ILBGXUMGSA-N 382933 US10273259, Example 644 Nuclear receptor ROR-gamma Mus musculus 34.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382933&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678866 404852253 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765544 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCOCC1 InChI=1S/C27H26F8N2O4S/c28-18-3-5-20(6-4-18)42(39,40)24-11-12-37(23(38)36-19-9-13-41-14-10-19)22(24)8-1-16-15-17(2-7-21(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,19,22H,1,8-14H2,(H,36,38)/t22-,24-/m1/s1 ONUATVHRHOYOBG-ISKFKSNPSA-N 382934 US10273259, Example 645::US10711020, Example 645 Nuclear receptor ROR-gamma Mus musculus 22.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382934&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679253 404852254 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765545 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Nc1ccncc1 InChI=1S/C27H21F8N3O3S/c28-18-3-5-20(6-4-18)42(40,41)24-11-14-38(23(39)37-19-9-12-36-13-10-19)22(24)8-1-16-15-17(2-7-21(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,9-10,12-13,15,22H,1,8,11,14H2,(H,36,37,39)/t22-,24-/m1/s1 HBERPHXXGYULDT-ISKFKSNPSA-N 382935 US10273259, Example 646::US10711020, Example 646 Nuclear receptor ROR-gamma Mus musculus 30.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382935&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679223 404852255 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765546 CC(C)(O)CNC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F8N2O4S/c1-22(2,38)14-35-21(37)36-12-11-23(41(39,40)18-7-5-17(27)6-8-18)19-9-4-16(13-15(19)3-10-20(23)36)24(28,25(29,30)31)26(32,33)34/h4-9,13,20,38H,3,10-12,14H2,1-2H3,(H,35,37)/t20-,23-/m1/s1 AYYPMMBZWYNXND-NFBKMPQASA-N 382936 US10273259, Example 647::US10711020, Example 647 Nuclear receptor ROR-gamma Mus musculus 37.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382936&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679038 404852256 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765547 CC(C)(O)CCNC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H28F8N2O4S/c1-23(2,39)11-13-36-22(38)37-14-12-24(42(40,41)19-7-5-18(28)6-8-19)20-9-4-17(15-16(20)3-10-21(24)37)25(29,26(30,31)32)27(33,34)35/h4-9,15,21,39H,3,10-14H2,1-2H3,(H,36,38)/t21-,24-/m1/s1 NNHDCRJVOBNWPH-ZJSXRUAMSA-N 382937 US10273259, Example 648::US10711020, Example 648 Nuclear receptor ROR-gamma Mus musculus 31.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382937&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678882 404852257 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765548 CC(C)(O)[C@H](F)CNC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F9N2O4S/c1-23(2,40)20(29)14-37-22(39)38-12-11-24(43(41,42)18-7-5-17(28)6-8-18)19-9-4-16(13-15(19)3-10-21(24)38)25(30,26(31,32)33)27(34,35)36/h4-9,13,20-21,40H,3,10-12,14H2,1-2H3,(H,37,39)/t20-,21-,24-/m1/s1 UKIAFMXJMJVHSC-PQNGQFLHSA-N 382938 US10273259, Example 649::US10711020, Example 649 Nuclear receptor ROR-gamma Mus musculus 32.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382938&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678743 404852258 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765549 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)Nc1ccnnc1 InChI=1S/C26H20F8N4O3S/c27-17-3-5-19(6-4-17)42(40,41)23-10-12-38(22(39)37-18-9-11-35-36-14-18)21(23)8-1-15-13-16(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,9,11,13-14,21H,1,8,10,12H2,(H,35,37,39)/t21-,23-/m1/s1 IGUMWSPIYUZTAI-FYYLOGMGSA-N 382939 US10273259, Example 650::US10711020, Example 650 Nuclear receptor ROR-gamma Mus musculus 86.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382939&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679081 404852259 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765550 OC(=O)[C@@H]1CCCN(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-19-5-7-20(8-6-19)44(42,43)25-11-13-38(24(41)37-12-1-2-17(15-37)23(39)40)22(25)10-3-16-14-18(4-9-21(16)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,17,22H,1-3,10-13,15H2,(H,39,40)/t17-,22-,25-/m1/s1 PRURFRCVWVOAKR-CFRFINDLSA-N 382940 US10273259, Example 651::US10711020, Example 651 Nuclear receptor ROR-gamma Mus musculus 278 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382940&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679233 404852260 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765551 OC(=O)C1CCN(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-19-3-5-20(6-4-19)44(42,43)25-11-14-38(24(41)37-12-9-16(10-13-37)23(39)40)22(25)8-1-17-15-18(2-7-21(17)25)26(30,27(31,32)33)28(34,35)36/h2-7,15-16,22H,1,8-14H2,(H,39,40)/t22-,25-/m1/s1 MXLBLRQWSDBOJA-RCZVLFRGSA-N 382941 US10273259, Example 652::US10711020, Example 652 Nuclear receptor ROR-gamma Mus musculus 115 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382941&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678764 404852261 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765552 OC(=O)[C@H]1CCCN(C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H26F8N2O5S/c29-19-5-7-20(8-6-19)44(42,43)25-11-13-38(24(41)37-12-1-2-17(15-37)23(39)40)22(25)10-3-16-14-18(4-9-21(16)25)26(30,27(31,32)33)28(34,35)36/h4-9,14,17,22H,1-3,10-13,15H2,(H,39,40)/t17-,22+,25+/m0/s1 PRURFRCVWVOAKR-CBCWYDDASA-N 382942 US10273259, Example 653::US10711020, Example 653 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382942&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678742 404852262 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765553 OC(=O)C1CCN(CC1)S(=O)(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O6S2/c27-18-2-4-19(5-3-18)43(39,40)23-9-12-36(44(41,42)35-10-7-15(8-11-35)22(37)38)21(23)14-16-13-17(1-6-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,15,21H,7-12,14H2,(H,37,38) CLJUYYRVVUBGCI-UHFFFAOYSA-N 382943 US10273259, Example 654::US10711020, Example 654 Nuclear receptor ROR-gamma Mus musculus 4676 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382943&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679244 404852263 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765554 Fc1ccc(cc1)S(=O)(=O)C12CCN(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCOCC1 InChI=1S/C26H24F8N2O4S/c27-17-2-4-19(5-3-17)41(38,39)23-9-10-36(22(37)35-18-7-11-40-12-8-18)21(23)14-15-13-16(1-6-20(15)23)24(28,25(29,30)31)26(32,33)34/h1-6,13,18,21H,7-12,14H2,(H,35,37) OCQDYRGXGGPYLB-UHFFFAOYSA-N 382944 US10273259, Example 655::US10711020, Example 655 Nuclear receptor ROR-gamma Mus musculus 1175 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382944&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679236 404852264 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765555 CC(C)(O)CNC(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O4S/c1-21(2,37)13-34-20(36)35-10-9-22(40(38,39)17-6-4-16(26)5-7-17)18-8-3-15(11-14(18)12-19(22)35)23(27,24(28,29)30)25(31,32)33/h3-8,11,19,37H,9-10,12-13H2,1-2H3,(H,34,36) BVMFCTGBLBEZTL-UHFFFAOYSA-N 382945 US10273259, Example 656::US10711020, Example 656 Nuclear receptor ROR-gamma Mus musculus 1380 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382945&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679099 404852265 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765556 OC(=O)C1CCN(CC1)C(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H24F8N2O5S/c28-18-2-4-19(5-3-18)43(41,42)24-9-12-37(23(40)36-10-7-15(8-11-36)22(38)39)21(24)14-16-13-17(1-6-20(16)24)25(29,26(30,31)32)27(33,34)35/h1-6,13,15,21H,7-12,14H2,(H,38,39) ZERAJJWDUHTGAJ-UHFFFAOYSA-N 382946 US10273259, Example 657::US10711020, Example 657 Nuclear receptor ROR-gamma Mus musculus 38.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382946&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679069 404852266 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765557 CC(C)(O)CCNC(=O)N1CCC2(C1Cc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H26F8N2O4S/c1-22(2,38)9-11-35-21(37)36-12-10-23(41(39,40)18-6-4-17(27)5-7-18)19-8-3-16(13-15(19)14-20(23)36)24(28,25(29,30)31)26(32,33)34/h3-8,13,20,38H,9-12,14H2,1-2H3,(H,35,37) GHQBHJDDESLOGZ-UHFFFAOYSA-N 382947 US10273259, Example 658::US10711020, Example 658 Nuclear receptor ROR-gamma Mus musculus 1269 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382947&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679251 404852267 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765558 CC(C)(O)CNC(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H26F8N2O4S/c1-22(2,38)13-35-21(37)36-12-17-4-3-15-11-16(24(28,25(29,30)31)26(32,33)34)5-10-20(15)23(17,14-36)41(39,40)19-8-6-18(27)7-9-19/h5-11,17,38H,3-4,12-14H2,1-2H3,(H,35,37) NFVJVVVFZUHLOG-UHFFFAOYSA-N 382948 US10273259, Example 659::US10711020, Example 659 Nuclear receptor ROR-gamma Mus musculus 340 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382948&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679258 404852268 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765559 CC1CN(CCC1C(O)=O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H28F8N2O5S/c1-16-13-38(11-10-22(16)24(40)41)25(42)39-14-19-3-2-17-12-18(27(31,28(32,33)34)29(35,36)37)4-9-23(17)26(19,15-39)45(43,44)21-7-5-20(30)6-8-21/h4-9,12,16,19,22H,2-3,10-11,13-15H2,1H3,(H,40,41) XATIWMZAXMBEPE-UHFFFAOYSA-N 382949 US10273259, Example 660::US10273259, Example 662::US10711020, Example 662 Nuclear receptor ROR-gamma Mus musculus 174 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382949&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678848 404852269 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765560 COC(=O)C1CCN(CC1C)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H30F8N2O5S/c1-17-14-39(12-11-23(17)25(41)45-2)26(42)40-15-20-4-3-18-13-19(28(32,29(33,34)35)30(36,37)38)5-10-24(18)27(20,16-40)46(43,44)22-8-6-21(31)7-9-22/h5-10,13,17,20,23H,3-4,11-12,14-16H2,1-2H3 FVWNIKIQLYBQGY-UHFFFAOYSA-N 382950 US10273259, Example 661::US10273259, Example 663::US10711020, Example 663 Nuclear receptor ROR-gamma Mus musculus 10.00 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382950&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679240 404852270 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765561 CC1CN(CCC1C(O)=O)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H28F8N2O5S/c1-16-13-38(11-10-22(16)24(40)41)25(42)39-14-19-3-2-17-12-18(27(31,28(32,33)34)29(35,36)37)4-9-23(17)26(19,15-39)45(43,44)21-7-5-20(30)6-8-21/h4-9,12,16,19,22H,2-3,10-11,13-15H2,1H3,(H,40,41) XATIWMZAXMBEPE-UHFFFAOYSA-N 382949 US10273259, Example 660::US10273259, Example 662::US10711020, Example 662 Nuclear receptor ROR-gamma Mus musculus 546 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382949&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678848 404852269 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765562 COC(=O)C1CCN(CC1C)C(=O)N1CC2CCc3cc(ccc3C2(C1)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H30F8N2O5S/c1-17-14-39(12-11-23(17)25(41)45-2)26(42)40-15-20-4-3-18-13-19(28(32,29(33,34)35)30(36,37)38)5-10-24(18)27(20,16-40)46(43,44)22-8-6-21(31)7-9-22/h5-10,13,17,20,23H,3-4,11-12,14-16H2,1-2H3 FVWNIKIQLYBQGY-UHFFFAOYSA-N 382950 US10273259, Example 661::US10273259, Example 663::US10711020, Example 663 Nuclear receptor ROR-gamma Mus musculus 1613 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382950&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679240 404852270 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765563 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCS(=O)(=O)CC1 InChI=1S/C27H26F8N2O5S2/c28-18-3-5-20(6-4-18)44(41,42)24-11-12-37(23(38)36-19-9-13-43(39,40)14-10-19)22(24)8-1-16-15-17(2-7-21(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,19,22H,1,8-14H2,(H,36,38)/t22-,24-/m1/s1 XGPWZCSOAMGQEU-ISKFKSNPSA-N 382953 US10273259, Example 664::US10711020, Example 664 Nuclear receptor ROR-gamma Mus musculus 23.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382953&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679119 404852271 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765564 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)CC1 InChI=1S/C28H28F8N2O5S2/c29-20-3-5-21(6-4-20)45(42,43)25-11-12-38(24(39)37-16-17-9-13-44(40,41)14-10-17)23(25)8-1-18-15-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,17,23H,1,8-14,16H2,(H,37,39)/t23-,25-/m1/s1 OZSZNLKIRBSEAE-ILBGXUMGSA-N 382954 US10273259, Example 665::US10711020, Example 665 Nuclear receptor ROR-gamma Mus musculus 15.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382954&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678686 404852272 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765565 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCS(=O)(=O)CC1 InChI=1S/C26H24F8N2O5S2/c27-18-3-5-19(6-4-18)43(40,41)23-9-10-36(22(37)35-11-13-42(38,39)14-12-35)21(23)8-1-16-15-17(2-7-20(16)23)24(28,25(29,30)31)26(32,33)34/h2-7,15,21H,1,8-14H2/t21-,23-/m1/s1 PTRKYEOXRKXYKH-FYYLOGMGSA-N 382955 US10273259, Example 666::US10711020, Example 666 Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382955&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678711 404852273 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765566 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)C1 InChI=1S/C27H26F8N2O5S2/c28-19-3-5-20(6-4-19)44(41,42)24-10-11-37(23(38)36-14-16-9-12-43(39,40)15-16)22(24)8-1-17-13-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,13,16,22H,1,8-12,14-15H2,(H,36,38)/t16?,22-,24-/m1/s1 FGXHDTAXBYJCLZ-QOPVDAPCSA-N 382956 US10273259, Example 667 Nuclear receptor ROR-gamma Mus musculus 17.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382956&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679100 404852274 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765567 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C26H24F8N2O5S2/c27-17-3-5-19(6-4-17)43(40,41)23-10-11-36(22(37)35-18-9-12-42(38,39)14-18)21(23)8-1-15-13-16(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,18,21H,1,8-12,14H2,(H,35,37)/t18?,21-,23-/m1/s1 BALSXRCVZGNGOG-QOYLUPDXSA-N 382957 US10273259, Example 668 Nuclear receptor ROR-gamma Mus musculus 47.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382957&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679129 404852275 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765568 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CC(C1)N1CCS(=O)(=O)CC1 InChI=1S/C29H29F8N3O5S2/c30-20-3-5-22(6-4-20)47(44,45)26-9-10-40(25(41)39-16-21(17-39)38-11-13-46(42,43)14-12-38)24(26)8-1-18-15-19(2-7-23(18)26)27(31,28(32,33)34)29(35,36)37/h2-7,15,21,24H,1,8-14,16-17H2/t24-,26-/m1/s1 RDYDOEMKXIJFHH-AOYPEHQESA-N 382958 US10273259, Example 669::US10711020, Example 669 Nuclear receptor ROR-gamma Mus musculus 39.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382958&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679249 404852276 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765569 CC1CS(=O)(=O)CCN1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O5S2/c1-16-15-43(39,40)13-12-36(16)23(38)37-11-10-24(44(41,42)20-6-4-19(28)5-7-20)21-8-3-18(14-17(21)2-9-22(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,14,16,22H,2,9-13,15H2,1H3/t16?,22-,24-/m1/s1 QYNCLJBULIZGFP-QOPVDAPCSA-N 382959 US10273259, Example 670::US10711020, Example 670 Nuclear receptor ROR-gamma Mus musculus 24.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382959&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678859 404852277 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765570 CN(C1CCS(=O)(=O)C1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8N2O5S2/c1-36(19-10-13-43(39,40)15-19)23(38)37-12-11-24(44(41,42)20-6-4-18(28)5-7-20)21-8-3-17(14-16(21)2-9-22(24)37)25(29,26(30,31)32)27(33,34)35/h3-8,14,19,22H,2,9-13,15H2,1H3/t19?,22-,24-/m1/s1 UIXBKKDQMQOIHY-WXEBLKNKSA-N 382960 US10273259, Example 671 Nuclear receptor ROR-gamma Mus musculus 32.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382960&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679235 404852278 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765571 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N(C1CC1)C1CCS(=O)(=O)C1 InChI=1S/C29H28F8N2O5S2/c30-19-3-7-22(8-4-19)46(43,44)26-12-13-38(25(40)39(20-5-6-20)21-11-14-45(41,42)16-21)24(26)10-1-17-15-18(2-9-23(17)26)27(31,28(32,33)34)29(35,36)37/h2-4,7-9,15,20-21,24H,1,5-6,10-14,16H2/t21?,24-,26-/m1/s1 FYCYKRHVNIOIMO-GVCDQIDYSA-N 382961 US10273259, Example 672 Nuclear receptor ROR-gamma Mus musculus 65.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382961&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678874 404852279 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765572 CC(=O)NC1CS(=O)(=O)CCC1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O6S2/c1-16(41)38-23-15-47(43,44)13-10-22(23)39-25(42)40-12-11-26(48(45,46)20-6-4-19(30)5-7-20)21-8-3-18(14-17(21)2-9-24(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,14,22-24H,2,9-13,15H2,1H3,(H,38,41)(H,39,42)/t22?,23?,24-,26-/m1/s1 UMHRTWJGSIYIHV-SFASGRJPSA-N 382962 US10273259, Example 673 Nuclear receptor ROR-gamma Mus musculus 39.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382962&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678844 404852280 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765573 OC1CS(=O)(=O)CC1NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8N2O6S2/c27-16-3-5-17(6-4-16)44(41,42)23-9-10-36(22(38)35-19-12-43(39,40)13-20(19)37)21(23)8-1-14-11-15(2-7-18(14)23)24(28,25(29,30)31)26(32,33)34/h2-7,11,19-21,37H,1,8-10,12-13H2,(H,35,38)/t19?,20?,21-,23-/m1/s1 ZBRROVURFKFQJX-UPSGKMMVSA-N 382963 US10273259, Example 674 Nuclear receptor ROR-gamma Mus musculus 51.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382963&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679234 404852281 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765574 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C26H24F8N2O5S2/c27-17-3-5-19(6-4-17)43(40,41)23-10-11-36(22(37)35-18-9-12-42(38,39)14-18)21(23)8-1-15-13-16(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,18,21H,1,8-12,14H2,(H,35,37)/t18?,21-,23-/m1/s1 BALSXRCVZGNGOG-QOYLUPDXSA-N 382964 US10273259, Example 675::US10273259, Example 676::US10711020, Example 676 Nuclear receptor ROR-gamma Mus musculus 57.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382964&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679129 404852282 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765575 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NC1CCS(=O)(=O)C1 InChI=1S/C26H24F8N2O5S2/c27-17-3-5-19(6-4-17)43(40,41)23-10-11-36(22(37)35-18-9-12-42(38,39)14-18)21(23)8-1-15-13-16(2-7-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-7,13,18,21H,1,8-12,14H2,(H,35,37)/t18?,21-,23-/m1/s1 BALSXRCVZGNGOG-QOYLUPDXSA-N 382964 US10273259, Example 675::US10273259, Example 676::US10711020, Example 676 Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382964&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679129 404852282 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765576 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1CCNC2CS(=O)(=O)CC12 InChI=1S/C28H27F8N3O5S2/c29-18-3-5-19(6-4-18)46(43,44)25-9-11-39(24(40)38-12-10-37-21-14-45(41,42)15-22(21)38)23(25)8-1-16-13-17(2-7-20(16)25)26(30,27(31,32)33)28(34,35)36/h2-7,13,21-23,37H,1,8-12,14-15H2/t21?,22?,23-,25-/m1/s1 KQSRNXPQNAWNLP-WXOOSPASSA-N 382966 US10273259, Example 677::US10711020, Example 677 Nuclear receptor ROR-gamma Mus musculus 79.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382966&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679248 404852283 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765577 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)C1 InChI=1S/C27H26F8N2O5S2/c28-19-3-5-20(6-4-19)44(41,42)24-10-11-37(23(38)36-14-16-9-12-43(39,40)15-16)22(24)8-1-17-13-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,13,16,22H,1,8-12,14-15H2,(H,36,38)/t16?,22-,24-/m1/s1 FGXHDTAXBYJCLZ-QOPVDAPCSA-N 382967 US10273259, Example 678::US10273259, Example 679::US10711020, Example 679 Nuclear receptor ROR-gamma Mus musculus 105 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382967&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679100 404852284 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765578 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)NCC1CCS(=O)(=O)C1 InChI=1S/C27H26F8N2O5S2/c28-19-3-5-20(6-4-19)44(41,42)24-10-11-37(23(38)36-14-16-9-12-43(39,40)15-16)22(24)8-1-17-13-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,13,16,22H,1,8-12,14-15H2,(H,36,38)/t16?,22-,24-/m1/s1 FGXHDTAXBYJCLZ-QOPVDAPCSA-N 382967 US10273259, Example 678::US10273259, Example 679::US10711020, Example 679 Nuclear receptor ROR-gamma Mus musculus 231 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382967&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679100 404852284 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765579 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)N1C[C@@H]2C[C@H]1CS2(=O)=O InChI=1S/C27H24F8N2O5S2/c28-17-3-5-19(6-4-17)44(41,42)24-9-10-36(23(38)37-13-20-12-18(37)14-43(20,39)40)22(24)8-1-15-11-16(2-7-21(15)24)25(29,26(30,31)32)27(33,34)35/h2-7,11,18,20,22H,1,8-10,12-14H2/t18-,20-,22+,24+/m0/s1 DNITVOXCCINEJP-YCYVKTGYSA-N 382969 US10273259, Example 680::US10711020, Example 680 Nuclear receptor ROR-gamma Mus musculus 151 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382969&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679074 404852285 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765580 CN(C1CCOCC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O4S/c1-37(20-10-14-42-15-11-20)24(39)38-13-12-25(43(40,41)21-6-4-19(29)5-7-21)22-8-3-18(16-17(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,16,20,23H,2,9-15H2,1H3/t23-,25-/m1/s1 HRNUXDBLBPTVKM-ILBGXUMGSA-N 382970 US10273259, Example 681::US10711020, Example 681 Nuclear receptor ROR-gamma Mus musculus 193 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382970&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678890 404852286 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765581 CS(=O)(=O)N1CCN(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8N3O5S2/c1-44(40,41)37-14-12-36(13-15-37)23(39)38-11-10-24(45(42,43)20-6-4-19(28)5-7-20)21-8-3-18(16-17(21)2-9-22(24)38)25(29,26(30,31)32)27(33,34)35/h3-8,16,22H,2,9-15H2,1H3/t22-,24-/m1/s1 IRUAZYZASURAHM-ISKFKSNPSA-N 382971 US10273259, Example 682::US10711020, Example 682 Nuclear receptor ROR-gamma Mus musculus 159 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382971&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679133 404852287 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765582 CS(=O)(=O)N1CCC(CC1)NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H29F8N3O5S2/c1-45(41,42)38-13-10-20(11-14-38)37-24(40)39-15-12-25(46(43,44)21-6-4-19(29)5-7-21)22-8-3-18(16-17(22)2-9-23(25)39)26(30,27(31,32)33)28(34,35)36/h3-8,16,20,23H,2,9-15H2,1H3,(H,37,40)/t23-,25-/m1/s1 YTIIUMWVHSWJMX-ILBGXUMGSA-N 382972 US10273259, Example 683::US10711020, Example 683 Nuclear receptor ROR-gamma Mus musculus 210 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382972&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679254 404852288 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765583 CS(=O)(=O)C1CCC(CC1)NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H30F8N2O5S2/c1-45(41,42)21-10-6-20(7-11-21)38-25(40)39-15-14-26(46(43,44)22-8-4-19(30)5-9-22)23-12-3-18(16-17(23)2-13-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-5,8-9,12,16,20-21,24H,2,6-7,10-11,13-15H2,1H3,(H,38,40)/t20?,21?,24-,26-/m1/s1 FGAUFDNSMRAGSL-ZCYSNTRLSA-N 382973 US10273259, Example 684::US10711020, Example 684 Nuclear receptor ROR-gamma Mus musculus 243 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382973&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679107 404852289 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765584 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-15-23-26(45(43,44)20-9-7-19(30)8-10-20,12-13-39(23)24(40)16-2-4-17(5-3-16)25(41)42)21-11-6-18(14-22(21)38)27(31,28(32,33)34)29(35,36)37/h6-11,14,16-17,23H,2-5,12-13,15H2,1H3,(H,41,42)/t16-,17-,23?,26? JDAJQYNRMPEXFU-LRVXPCDCSA-N 382974 (1r,4r)-4-(9b-((4-fluorophenyl)sulfonyl)-5-methyl-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-c]quinoline-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 685::US10273259, Example 688::US10711020, Example 688 Nuclear receptor ROR-gamma Mus musculus 28.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382974&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669243 404852290 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765585 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-16-24-27(46(44,45)21-10-8-20(31)9-11-21,13-14-40(24)25(41)17-3-5-18(6-4-17)26(42)43)22-12-7-19(15-23(22)39)28(32,29(33,34)35)30(36,37)38/h7-12,15,17-18,24H,2-6,13-14,16H2,1H3,(H,42,43)/t17-,18-,24?,27? NXUBBEJNBJAHRO-VRSFHCCXSA-N 382975 US10273259, Example 686::US10273259, Example 687::US10711020, Example 687 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382975&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678737 404852291 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765586 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-16-24-27(46(44,45)21-10-8-20(31)9-11-21,13-14-40(24)25(41)17-3-5-18(6-4-17)26(42)43)22-12-7-19(15-23(22)39)28(32,29(33,34)35)30(36,37)38/h7-12,15,17-18,24H,2-6,13-14,16H2,1H3,(H,42,43)/t17-,18-,24?,27? NXUBBEJNBJAHRO-VRSFHCCXSA-N 382975 US10273259, Example 686::US10273259, Example 687::US10711020, Example 687 Nuclear receptor ROR-gamma Mus musculus 7301 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382975&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678737 404852291 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765587 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-15-23-26(45(43,44)20-9-7-19(30)8-10-20,12-13-39(23)24(40)16-2-4-17(5-3-16)25(41)42)21-11-6-18(14-22(21)38)27(31,28(32,33)34)29(35,36)37/h6-11,14,16-17,23H,2-5,12-13,15H2,1H3,(H,41,42)/t16-,17-,23?,26? JDAJQYNRMPEXFU-LRVXPCDCSA-N 382974 (1r,4r)-4-(9b-((4-fluorophenyl)sulfonyl)-5-methyl-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-c]quinoline-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 685::US10273259, Example 688::US10711020, Example 688 Nuclear receptor ROR-gamma Mus musculus 57.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382974&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669243 404852290 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765588 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C31H30F8N2O5S/c1-40-17-23-28(47(45,46)20-5-3-19(32)4-6-20,21-7-2-18(16-22(21)40)29(33,30(34,35)36)31(37,38)39)14-15-41(23)24(42)26-8-11-27(12-9-26,13-10-26)25(43)44/h2-7,16,23H,8-15,17H2,1H3,(H,43,44) CERZXMFNZUFKEF-UHFFFAOYSA-N 382978 US10273259, Example 689::US10711020, Example 689 Nuclear receptor ROR-gamma Mus musculus 40.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382978&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123584 404852292 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765589 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C32H32F8N2O5S/c1-2-41-18-24-29(48(46,47)21-6-4-20(33)5-7-21,22-8-3-19(17-23(22)41)30(34,31(35,36)37)32(38,39)40)15-16-42(24)25(43)27-9-12-28(13-10-27,14-11-27)26(44)45/h3-8,17,24H,2,9-16,18H2,1H3,(H,44,45) WLOVMJJQDDUFPW-UHFFFAOYSA-N 382979 US10273259, Example 690::US10711020, Example 690 Nuclear receptor ROR-gamma Mus musculus 44.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382979&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678872 404852293 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765590 CCCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C33H34F8N2O5S/c1-2-16-42-19-25-30(49(47,48)22-6-4-21(34)5-7-22,23-8-3-20(18-24(23)42)31(35,32(36,37)38)33(39,40)41)15-17-43(25)26(44)28-9-12-29(13-10-28,14-11-28)27(45)46/h3-8,18,25H,2,9-17,19H2,1H3,(H,45,46) BVAKEDKWJDWPMS-UHFFFAOYSA-N 382980 US10273259, Example 691::US10711020, Example 691 Nuclear receptor ROR-gamma Mus musculus 143 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382980&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679101 404852294 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765591 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C31H32F8N2O5S/c1-3-40-17-24-28(47(45,46)21-7-5-20(32)6-8-21,14-15-41(24)25(42)18-10-12-27(2,13-11-18)26(43)44)22-9-4-19(16-23(22)40)29(33,30(34,35)36)31(37,38)39/h4-9,16,18,24H,3,10-15,17H2,1-2H3,(H,43,44)/t18-,24?,27-,28? DSFYJEOIAKCMFQ-GLMFJJLTSA-N 382981 US10273259, Example 692::US10711020, Example 692 Nuclear receptor ROR-gamma Mus musculus 4.00 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382981&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679110 404852295 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765592 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C29H27F9N2O5S/c1-39-15-22-26(46(44,45)19-5-3-18(30)4-6-19,12-13-40(22)24(43)25(31)10-8-16(9-11-25)23(41)42)20-7-2-17(14-21(20)39)27(32,28(33,34)35)29(36,37)38/h2-7,14,16,22H,8-13,15H2,1H3,(H,41,42)/t16-,22?,25+,26? BBBIQZWUOQKZRQ-VXBFRIGJSA-N 382982 US10273259, Example 693::US10711020, Example 693 Nuclear receptor ROR-gamma Mus musculus 625 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382982&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679241 404852296 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765593 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@](C)(CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-26(25(42)43)11-9-17(10-12-26)24(41)40-14-13-27(46(44,45)20-6-4-19(31)5-7-20)21-8-3-18(15-22(21)39(2)16-23(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,15,17,23H,9-14,16H2,1-2H3,(H,42,43)/t17-,23?,26-,27? SJWPZBFAJFYJBV-PYPIJRSMSA-N 382983 US10273259, Example 694::US10711020, Example 694 Nuclear receptor ROR-gamma Mus musculus 217 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382983&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 132123592 404852297 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765594 CCCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C31H31F9N2O5S/c1-2-14-41-17-24-28(48(46,47)21-6-4-20(32)5-7-21,13-15-42(24)26(45)27(33)11-9-18(10-12-27)25(43)44)22-8-3-19(16-23(22)41)29(34,30(35,36)37)31(38,39)40/h3-8,16,18,24H,2,9-15,17H2,1H3,(H,43,44)/t18-,24?,27+,28? JWKNRJRSZVICQO-UBOLYAJWSA-N 382984 US10273259, Example 695::US10711020, Example 695 Nuclear receptor ROR-gamma Mus musculus 225 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382984&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679265 404852298 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765595 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H29F9N2O5S/c1-2-40-16-23-27(47(45,46)20-6-4-19(31)5-7-20,13-14-41(23)25(44)26(32)11-9-17(10-12-26)24(42)43)21-8-3-18(15-22(21)40)28(33,29(34,35)36)30(37,38)39/h3-8,15,17,23H,2,9-14,16H2,1H3,(H,42,43)/t17-,23?,26+,27? ROAFSFHOECLXOK-MTOUGUCQSA-N 382985 US10273259, Example 696::US10711020, Example 696 Nuclear receptor ROR-gamma Mus musculus 218 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382985&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678521 404852299 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765596 CCCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F8N2O5S/c1-2-14-40-17-25-28(47(45,46)22-10-8-21(32)9-11-22,13-15-41(25)26(42)18-3-5-19(6-4-18)27(43)44)23-12-7-20(16-24(23)40)29(33,30(34,35)36)31(37,38)39/h7-12,16,18-19,25H,2-6,13-15,17H2,1H3,(H,43,44)/t18-,19-,25?,28? BTJFMVNGAMYMNQ-XUNNZJKZSA-N 382986 US10273259, Example 697::US10711020, Example 697 Nuclear receptor ROR-gamma Mus musculus 68.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382986&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679263 404852300 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765597 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C31H32F8N2O5S/c1-3-40-17-24-28(47(45,46)21-7-5-20(32)6-8-21,14-15-41(24)26(44)27(2)12-10-18(11-13-27)25(42)43)22-9-4-19(16-23(22)40)29(33,30(34,35)36)31(37,38)39/h4-9,16,18,24H,3,10-15,17H2,1-2H3,(H,42,43)/t18-,24?,27-,28? BPOZKIUVNUVESR-GLMFJJLTSA-N 382987 US10273259, Example 698::US10711020, Example 698 Nuclear receptor ROR-gamma Mus musculus 117 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382987&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678906 404852301 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765598 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@@]1(C)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-26(11-9-17(10-12-26)24(41)42)25(43)40-14-13-27(46(44,45)20-6-4-19(31)5-7-20)21-8-3-18(15-22(21)39(2)16-23(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,15,17,23H,9-14,16H2,1-2H3,(H,41,42)/t17-,23?,26-,27? ZEGBCCPROSAOGK-PYPIJRSMSA-N 382988 US10273259, Example 699::US10711020, Example 699 Nuclear receptor ROR-gamma Mus musculus 20.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382988&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678887 404852302 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765599 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H31F7N2O5S/c1-2-38-17-24-27(45(43,44)21-6-4-3-5-7-21,14-15-39(24)25(40)18-8-10-19(11-9-18)26(41)42)22-13-12-20(16-23(22)38)28(31,29(32,33)34)30(35,36)37/h3-7,12-13,16,18-19,24H,2,8-11,14-15,17H2,1H3,(H,41,42)/t18-,19-,24?,27? DYGOBAFRTDAHKQ-QXIWJBPRSA-N 382989 US10273259, Example 700::US10711020, Example 700 Nuclear receptor ROR-gamma Mus musculus 276 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382989&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678736 404852303 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765600 CCCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C31H33F7N2O5S/c1-2-15-39-18-25-28(46(44,45)22-6-4-3-5-7-22,14-16-40(25)26(41)19-8-10-20(11-9-19)27(42)43)23-13-12-21(17-24(23)39)29(32,30(33,34)35)31(36,37)38/h3-7,12-13,17,19-20,25H,2,8-11,14-16,18H2,1H3,(H,42,43)/t19-,20-,25?,28? NBSMWOUOIMKCAB-IUKKCNNLSA-N 382990 US10273259, Example 701::US10711020, Example 701 Nuclear receptor ROR-gamma Mus musculus 100.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382990&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678888 404852304 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765601 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H29F7N2O5S/c1-37-16-23-26(44(42,43)20-5-3-2-4-6-20,13-14-38(23)24(39)17-7-9-18(10-8-17)25(40)41)21-12-11-19(15-22(21)37)27(30,28(31,32)33)29(34,35)36/h2-6,11-12,15,17-18,23H,7-10,13-14,16H2,1H3,(H,40,41)/t17-,18-,23?,26? HJAHYEBMXFLUEJ-GIHSMNABSA-N 382991 US10273259, Example 702::US10711020, Example 702 Nuclear receptor ROR-gamma Mus musculus 51.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382991&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679256 404852305 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765602 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-15-23-26(45(43,44)20-4-2-3-19(30)14-20,11-12-39(23)24(40)16-5-7-17(8-6-16)25(41)42)21-10-9-18(13-22(21)38)27(31,28(32,33)34)29(35,36)37/h2-4,9-10,13-14,16-17,23H,5-8,11-12,15H2,1H3,(H,41,42)/t16-,17-,23?,26? GRGFWIALBLAFIO-LRVXPCDCSA-N 382992 US10273259, Example 703::US10273259, Example 714::US10711020, Example 714 Nuclear receptor ROR-gamma Mus musculus 1883 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382992&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678895 404852306 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765603 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-16-24-27(46(44,45)21-5-3-4-20(31)15-21,12-13-40(24)25(41)17-6-8-18(9-7-17)26(42)43)22-11-10-19(14-23(22)39)28(32,29(33,34)35)30(36,37)38/h3-5,10-11,14-15,17-18,24H,2,6-9,12-13,16H2,1H3,(H,42,43)/t17-,18-,24?,27? NBNXACNXXIMYCS-VRSFHCCXSA-N 382993 US10273259, Example 704::US10273259, Example 713::US10711020, Example 713 Nuclear receptor ROR-gamma Mus musculus 2125 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382993&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678902 404852307 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765604 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CN(C)c1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H24F9N3O4S/c1-37-13-21-24(44(42,43)16-5-3-4-15(28)11-16,8-9-39(21)23(41)20-12-18(29)22(40)38(20)2)17-7-6-14(10-19(17)37)25(30,26(31,32)33)27(34,35)36/h3-7,10-11,18,20-21H,8-9,12-13H2,1-2H3/t18-,20-,21?,24?/m0/s1 RRXIBUSZXQWSNN-ULJIEDDMSA-N 382994 US10273259, Example 705::US10273259, Example 716::US10711020, Example 716 Nuclear receptor ROR-gamma Mus musculus 1470 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382994&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995609 404852308 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765605 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H29F7N2O5S2/c1-2-36-17-23-25(44(41,42)20-6-4-3-5-7-20,12-13-37(23)24(38)18-10-14-43(39,40)15-11-18)21-9-8-19(16-22(21)36)26(29,27(30,31)32)28(33,34)35/h3-9,16,18,23H,2,10-15,17H2,1H3 DYLPRTXNTCIXCH-UHFFFAOYSA-N 382995 US10273259, Example 706::US10711020, Example 706 Nuclear receptor ROR-gamma Mus musculus 161 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382995&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678854 404852309 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765606 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H27F7N2O5S2/c1-35-16-22-24(43(40,41)19-5-3-2-4-6-19,11-12-36(22)23(37)17-9-13-42(38,39)14-10-17)20-8-7-18(15-21(20)35)25(28,26(29,30)31)27(32,33)34/h2-8,15,17,22H,9-14,16H2,1H3 SLRWDASWAUKALJ-UHFFFAOYSA-N 382996 US10273259, Example 707::US10711020, Example 707 Nuclear receptor ROR-gamma Mus musculus 43.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382996&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679252 404852310 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765607 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H26F8N2O5S2/c1-36-15-22-24(44(41,42)19-5-3-18(28)4-6-19,10-11-37(22)23(38)16-8-12-43(39,40)13-9-16)20-7-2-17(14-21(20)36)25(29,26(30,31)32)27(33,34)35/h2-7,14,16,22H,8-13,15H2,1H3 JFDWMQCQKZSUOY-UHFFFAOYSA-N 382997 US10273259, Example 708::US10711020, Example 708 Nuclear receptor ROR-gamma Mus musculus 15.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382997&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679192 404852311 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765608 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H28F8N2O5S2/c1-2-37-16-23-25(45(42,43)20-6-4-19(29)5-7-20,11-12-38(23)24(39)17-9-13-44(40,41)14-10-17)21-8-3-18(15-22(21)37)26(30,27(31,32)33)28(34,35)36/h3-8,15,17,23H,2,9-14,16H2,1H3 NMTKWMICLMJXTR-UHFFFAOYSA-N 382998 US10273259, Example 709::US10711020, Example 709 Nuclear receptor ROR-gamma Mus musculus 31.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382998&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678850 404852312 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765609 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C27H26F8N2O5S2/c1-36-15-22-24(44(41,42)19-4-2-3-18(28)14-19,9-10-37(22)23(38)16-7-11-43(39,40)12-8-16)20-6-5-17(13-21(20)36)25(29,26(30,31)32)27(33,34)35/h2-6,13-14,16,22H,7-12,15H2,1H3 QDMRCTNBBYEWGX-UHFFFAOYSA-N 382999 US10273259, Example 710::US10711020, Example 710 Nuclear receptor ROR-gamma Mus musculus 30.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382999&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679056 404852313 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765610 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-17-23-27(46(44,45)20-6-4-3-5-7-20,14-15-40(23)25(43)26(31)12-10-18(11-13-26)24(41)42)21-9-8-19(16-22(21)39)28(32,29(33,34)35)30(36,37)38/h3-9,16,18,23H,2,10-15,17H2,1H3,(H,41,42)/t18-,23?,26+,27? HFJJPNSOTVSZPX-MJALUPOVSA-N 383000 US10273259, Example 711::US10711020, Example 711 Nuclear receptor ROR-gamma Mus musculus 26.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383000&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679272 404852314 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765611 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-16-22-26(45(43,44)19-5-3-2-4-6-19,13-14-39(22)24(42)25(30)11-9-17(10-12-25)23(40)41)20-8-7-18(15-21(20)38)27(31,28(32,33)34)29(35,36)37/h2-8,15,17,22H,9-14,16H2,1H3,(H,40,41)/t17-,22?,25+,26? LDMASGNBXNKNES-ZZDDDDRDSA-N 383001 US10273259, Example 712::US10711020, Example 712 Nuclear receptor ROR-gamma Mus musculus 27.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383001&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678750 404852315 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765612 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30F8N2O5S/c1-2-39-16-24-27(46(44,45)21-5-3-4-20(31)15-21,12-13-40(24)25(41)17-6-8-18(9-7-17)26(42)43)22-11-10-19(14-23(22)39)28(32,29(33,34)35)30(36,37)38/h3-5,10-11,14-15,17-18,24H,2,6-9,12-13,16H2,1H3,(H,42,43)/t17-,18-,24?,27? NBNXACNXXIMYCS-VRSFHCCXSA-N 382993 US10273259, Example 704::US10273259, Example 713::US10711020, Example 713 Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382993&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678902 404852307 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765613 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C29H28F8N2O5S/c1-38-15-23-26(45(43,44)20-4-2-3-19(30)14-20,11-12-39(23)24(40)16-5-7-17(8-6-16)25(41)42)21-10-9-18(13-22(21)38)27(31,28(32,33)34)29(35,36)37/h2-4,9-10,13-14,16-17,23H,5-8,11-12,15H2,1H3,(H,41,42)/t16-,17-,23?,26? GRGFWIALBLAFIO-LRVXPCDCSA-N 382992 US10273259, Example 703::US10273259, Example 714::US10711020, Example 714 Nuclear receptor ROR-gamma Mus musculus 82.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382992&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678895 404852306 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765614 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C29H27F9N2O5S/c1-39-15-22-26(46(44,45)19-4-2-3-18(30)14-19,11-12-40(22)24(43)25(31)9-7-16(8-10-25)23(41)42)20-6-5-17(13-21(20)39)27(32,28(33,34)35)29(36,37)38/h2-6,13-14,16,22H,7-12,15H2,1H3,(H,41,42)/t16-,22?,25+,26? FMNWOCHOXUNIRW-VXBFRIGJSA-N 383004 US10273259, Example 715::US10711020, Example 715 Nuclear receptor ROR-gamma Mus musculus 30.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383004&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679128 404852316 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765615 CN1[C@@H](C[C@H](F)C1=O)C(=O)N1CCC2(C1CN(C)c1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C27H24F9N3O4S/c1-37-13-21-24(44(42,43)16-5-3-4-15(28)11-16,8-9-39(21)23(41)20-12-18(29)22(40)38(20)2)17-7-6-14(10-19(17)37)25(30,26(31,32)33)27(34,35)36/h3-7,10-11,18,20-21H,8-9,12-13H2,1-2H3/t18-,20-,21?,24?/m0/s1 RRXIBUSZXQWSNN-ULJIEDDMSA-N 382994 US10273259, Example 705::US10273259, Example 716::US10711020, Example 716 Nuclear receptor ROR-gamma Mus musculus 30.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382994&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995609 404852308 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765616 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)C1(O)CCS(=O)(=O)CC1 InChI=1S/C28H28F8N2O6S2/c1-2-37-16-22-25(46(43,44)19-6-4-18(29)5-7-19,9-12-38(22)23(39)24(40)10-13-45(41,42)14-11-24)20-8-3-17(15-21(20)37)26(30,27(31,32)33)28(34,35)36/h3-8,15,22,40H,2,9-14,16H2,1H3 WEVAOQONOCEOCA-UHFFFAOYSA-N 383006 US10273259, Example 717::US10711020, Example 717 Nuclear receptor ROR-gamma Mus musculus 70.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383006&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679151 404852317 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765617 CN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)[C@@]1(F)CC[C@@H](CC1)C(O)=O InChI=1S/C29H27ClF8N2O5S/c1-39-15-22-26(46(44,45)19-5-3-18(30)4-6-19,12-13-40(22)24(43)25(31)10-8-16(9-11-25)23(41)42)20-7-2-17(14-21(20)39)27(32,28(33,34)35)29(36,37)38/h2-7,14,16,22H,8-13,15H2,1H3,(H,41,42)/t16-,22?,25+,26? XAVVESOTQYRIKJ-VXBFRIGJSA-N 383007 US10273259, Example 718::US10711020, Example 718 Nuclear receptor ROR-gamma Mus musculus 76.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383007&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678771 404852318 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765618 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C30H30ClF7N2O5S/c1-2-39-16-24-27(46(44,45)21-10-8-20(31)9-11-21,13-14-40(24)25(41)17-3-5-18(6-4-17)26(42)43)22-12-7-19(15-23(22)39)28(32,29(33,34)35)30(36,37)38/h7-12,15,17-18,24H,2-6,13-14,16H2,1H3,(H,42,43)/t17-,18-,24?,27? MHZASLHOGPGBMN-VRSFHCCXSA-N 383008 US10273259, Example 719::US10711020, Example 719 Nuclear receptor ROR-gamma Mus musculus 295 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383008&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679134 404852319 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765619 CCN1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1)C(=O)C1CCS(=O)(=O)CC1 InChI=1S/C28H28ClF7N2O5S2/c1-2-37-16-23-25(45(42,43)20-6-4-19(29)5-7-20,11-12-38(23)24(39)17-9-13-44(40,41)14-10-17)21-8-3-18(15-22(21)37)26(30,27(31,32)33)28(34,35)36/h3-8,15,17,23H,2,9-14,16H2,1H3 WCOFXTZWIRUVBM-UHFFFAOYSA-N 383009 US10273259, Example 720::US10711020, Example 720 Nuclear receptor ROR-gamma Mus musculus 428 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383009&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678833 404852320 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765620 NC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H20F8N2O3S/c24-15-3-5-16(6-4-15)37(35,36)20-9-10-33(12-19(32)34)18(20)8-1-13-11-14(2-7-17(13)20)21(25,22(26,27)28)23(29,30)31/h2-7,11,18H,1,8-10,12H2,(H2,32,34)/t18-,20-/m1/s1 MVZQNVFLKJWGAB-UYAOXDASSA-N 383010 2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)acetamide::US10273259, Example 721::US10711020, Example 721 Nuclear receptor ROR-gamma Mus musculus 52.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383010&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669065 404852321 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765621 CC(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(N)=O InChI=1S/C24H22F8N2O3S/c1-13(20(33)35)34-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12-13,19H,2,9-11H2,1H3,(H2,33,35)/t13?,19-,21-/m1/s1 ASBWXSYJMRZXMQ-BTSGLNRLSA-N 383011 (RS)-2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)propanamide::US10273259, Example 722::US10711020, Example 722 Nuclear receptor ROR-gamma Mus musculus 73.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383011&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669125 404852322 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765622 CNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c1-33-20(35)13-34-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12,19H,2,9-11,13H2,1H3,(H,33,35)/t19-,21-/m1/s1 NOPYNBZXIYAOSY-TZIWHRDSSA-N 383012 2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)-N-(methyl-d3)acetamide::US10273259, Example 723::US10273259, Example 724::US10273259, Example 752::US10711020, Example 752 Nuclear receptor ROR-gamma Mus musculus 136 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383012&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679257 404852323 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765623 CNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c1-33-20(35)13-34-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12,19H,2,9-11,13H2,1H3,(H,33,35)/t19-,21-/m1/s1 NOPYNBZXIYAOSY-TZIWHRDSSA-N 383012 2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)-N-(methyl-d3)acetamide::US10273259, Example 723::US10273259, Example 724::US10273259, Example 752::US10711020, Example 752 Nuclear receptor ROR-gamma Mus musculus 142 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383012&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679257 404852323 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765624 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(CC(=O)N3CCOCC3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C27H26F8N2O4S/c28-19-3-5-20(6-4-19)42(39,40)24-9-10-37(16-23(38)36-11-13-41-14-12-36)22(24)8-1-17-15-18(2-7-21(17)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,22H,1,8-14,16H2/t22-,24-/m1/s1 IDHGOYVHCYWYON-ISKFKSNPSA-N 383014 US10273259, Example 725::US10711020, Example 725 Nuclear receptor ROR-gamma Mus musculus 95.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383014&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679067 404852324 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765625 CCOC(=O)Cc1csc(NC(=O)CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)n1 InChI=1S/C30H27F8N3O5S2/c1-2-46-25(43)14-20-16-47-26(39-20)40-24(42)15-41-12-11-27(48(44,45)21-7-5-19(31)6-8-21)22-9-4-18(13-17(22)3-10-23(27)41)28(32,29(33,34)35)30(36,37)38/h4-9,13,16,23H,2-3,10-12,14-15H2,1H3,(H,39,40,42)/t23-,27-/m1/s1 KQTAMRQPWNHHKW-YIXXDRMTSA-N 383015 US10273259, Example 726::US10711020, Example 726 Nuclear receptor ROR-gamma Mus musculus 114 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383015&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679275 404852325 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765626 OC(=O)Cc1csc(NC(=O)CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)n1 InChI=1S/C28H23F8N3O5S2/c29-17-3-5-19(6-4-17)46(43,44)25-9-10-39(13-22(40)38-24-37-18(14-45-24)12-23(41)42)21(25)8-1-15-11-16(2-7-20(15)25)26(30,27(31,32)33)28(34,35)36/h2-7,11,14,21H,1,8-10,12-13H2,(H,41,42)(H,37,38,40)/t21-,25-/m1/s1 VKXMKEOKORZLRT-PXDATVDWSA-N 383016 US10273259, Example 727::US10711020, Example 727 Nuclear receptor ROR-gamma Mus musculus 77.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383016&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679246 404852326 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765627 CN(C)C(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-34(2)21(36)14-35-12-11-22(39(37,38)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)35)23(27,24(28,29)30)25(31,32)33/h4-9,13,20H,3,10-12,14H2,1-2H3/t20-,22-/m1/s1 BVWDTPOUDOUZHX-IFMALSPDSA-N 383017 US10273259, Example 728::US10711020, Example 728 Nuclear receptor ROR-gamma Mus musculus 77.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383017&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678773 404852327 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765628 NC(=O)CCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c25-16-3-5-17(6-4-16)38(36,37)21-10-12-34(11-9-20(33)35)19(21)8-1-14-13-15(2-7-18(14)21)22(26,23(27,28)29)24(30,31)32/h2-7,13,19H,1,8-12H2,(H2,33,35)/t19-,21-/m1/s1 ULYUEKJPYPRTPZ-TZIWHRDSSA-N 383018 US10273259, Example 729::US10711020, Example 729 Nuclear receptor ROR-gamma Mus musculus 52.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383018&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679266 404852328 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765629 OC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H19F8NO4S/c24-15-3-5-16(6-4-15)37(35,36)20-9-10-32(12-19(33)34)18(20)8-1-13-11-14(2-7-17(13)20)21(25,22(26,27)28)23(29,30)31/h2-7,11,18H,1,8-10,12H2,(H,33,34)/t18-,20-/m1/s1 QZDXZFOARXONJV-UYAOXDASSA-N 383019 US10273259, Example 730::US10711020, Example 730 Nuclear receptor ROR-gamma Mus musculus 82.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383019&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669192 404852329 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765630 OC(=O)CCCCCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H27F8NO4S/c28-19-7-9-20(10-8-19)41(39,40)24-13-15-36(14-3-1-2-4-23(37)38)22(24)12-5-17-16-18(6-11-21(17)24)25(29,26(30,31)32)27(33,34)35/h6-11,16,22H,1-5,12-15H2,(H,37,38)/t22-,24-/m1/s1 SUGZRDDXWKPQLH-ISKFKSNPSA-N 383020 US10273259, Example 731::US10711020, Example 731 Nuclear receptor ROR-gamma Mus musculus 119 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383020&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679080 404852330 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765631 OC(=O)CCCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H23F8NO4S/c26-17-5-7-18(8-6-17)39(37,38)22-11-13-34(12-1-2-21(35)36)20(22)10-3-15-14-16(4-9-19(15)22)23(27,24(28,29)30)25(31,32)33/h4-9,14,20H,1-3,10-13H2,(H,35,36)/t20-,22-/m1/s1 UTFSZTSRHCOILN-IFMALSPDSA-N 383021 US10273259, Example 732::US10711020, Example 732 Nuclear receptor ROR-gamma Mus musculus 44.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383021&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678891 404852331 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765632 OC(=O)CCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H21F8NO4S/c25-16-3-5-17(6-4-16)38(36,37)21-10-12-33(11-9-20(34)35)19(21)8-1-14-13-15(2-7-18(14)21)22(26,23(27,28)29)24(30,31)32/h2-7,13,19H,1,8-12H2,(H,34,35)/t19-,21-/m1/s1 PPHLYBDXZSLEKJ-TZIWHRDSSA-N 383022 US10273259, Example 733::US10711020, Example 733 Nuclear receptor ROR-gamma Mus musculus 332 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383022&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679088 404852332 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765633 OC(=O)CCCCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c27-18-6-8-19(9-7-18)40(38,39)23-12-14-35(13-2-1-3-22(36)37)21(23)11-4-16-15-17(5-10-20(16)23)24(28,25(29,30)31)26(32,33)34/h5-10,15,21H,1-4,11-14H2,(H,36,37)/t21-,23-/m1/s1 OKYCMYXKRFRHQW-FYYLOGMGSA-N 383023 US10273259, Example 734::US10711020, Example 734 Nuclear receptor ROR-gamma Mus musculus 131 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383023&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679154 404852333 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765634 CCOC(=O)C(F)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(O)cc1 InChI=1S/C25H24F7NO6S/c1-2-39-21(35)20(26)33-12-11-22(40(37,38)17-7-5-16(34)6-8-17)18-9-4-15(13-14(18)3-10-19(22)33)23(36,24(27,28)29)25(30,31)32/h4-9,13,19-20,34,36H,2-3,10-12H2,1H3/t19-,20?,22-/m1/s1 SRLWLKOAKBZNDW-ZAWSQKNBSA-N 383024 US10273259, Example 735 Nuclear receptor ROR-gamma Mus musculus 103 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383024&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678721 404852334 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765635 CCNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-2-34-21(36)14-35-12-11-22(39(37,38)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)35)23(27,24(28,29)30)25(31,32)33/h4-9,13,20H,2-3,10-12,14H2,1H3,(H,34,36)/t20-,22-/m1/s1 SVQFZYUQQHXZGD-IFMALSPDSA-N 383025 US10273259, Example 736::US10711020, Example 736 Nuclear receptor ROR-gamma Mus musculus 78.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383025&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679124 404852335 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765636 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(C3CCN(Cc4ccccc4)C3=O)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H28F8N2O3S/c33-23-8-10-24(11-9-23)46(44,45)29-15-17-42(26-14-16-41(28(26)43)19-20-4-2-1-3-5-20)27(29)13-6-21-18-22(7-12-25(21)29)30(34,31(35,36)37)32(38,39)40/h1-5,7-12,18,26-27H,6,13-17,19H2/t26?,27-,29-/m1/s1 ICLZCKRMOVORRX-GGMYVPERSA-N 383026 US10273259, Example 737::US10273259, Example 738::US10711020, Example 738 Nuclear receptor ROR-gamma Mus musculus 368 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383026&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678768 404852336 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765637 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(C3CCN(Cc4ccccc4)C3=O)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C32H28F8N2O3S/c33-23-8-10-24(11-9-23)46(44,45)29-15-17-42(26-14-16-41(28(26)43)19-20-4-2-1-3-5-20)27(29)13-6-21-18-22(7-12-25(21)29)30(34,31(35,36)37)32(38,39)40/h1-5,7-12,18,26-27H,6,13-17,19H2/t26?,27-,29-/m1/s1 ICLZCKRMOVORRX-GGMYVPERSA-N 383026 US10273259, Example 737::US10273259, Example 738::US10711020, Example 738 Nuclear receptor ROR-gamma Mus musculus 139 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383026&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678768 404852336 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765638 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(C3CCNC3=O)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H22F8N2O3S/c26-16-3-5-17(6-4-16)39(37,38)22-10-12-35(19-9-11-34-21(19)36)20(22)8-1-14-13-15(2-7-18(14)22)23(27,24(28,29)30)25(31,32)33/h2-7,13,19-20H,1,8-12H2,(H,34,36)/t19?,20-,22-/m1/s1 VLDIWJBHEQTZRM-NQUCAWMESA-N 383028 US10273259, Example 739::US10711020, Example 739 Nuclear receptor ROR-gamma Mus musculus 196 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383028&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678761 404852337 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765639 OC(=O)c1ccc2C(CCc2c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H25F8NO4S/c32-21-5-7-22(8-6-21)45(43,44)28-13-14-40(25-11-2-17-15-19(27(41)42)1-9-23(17)25)26(28)12-3-18-16-20(4-10-24(18)28)29(33,30(34,35)36)31(37,38)39/h1,4-10,15-16,25-26H,2-3,11-14H2,(H,41,42)/t25?,26-,28-/m1/s1 PICYUUMZGMTICO-BODSDZGOSA-N 383029 US10273259, Example 740::US10273259, Example 741::US10711020, Example 741 Nuclear receptor ROR-gamma Mus musculus 561 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383029&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678778 404852338 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765640 OC(=O)c1ccc2C(CCc2c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H25F8NO4S/c32-21-5-7-22(8-6-21)45(43,44)28-13-14-40(25-11-2-17-15-19(27(41)42)1-9-23(17)25)26(28)12-3-18-16-20(4-10-24(18)28)29(33,30(34,35)36)31(37,38)39/h1,4-10,15-16,25-26H,2-3,11-14H2,(H,41,42)/t25?,26-,28-/m1/s1 PICYUUMZGMTICO-BODSDZGOSA-N 383029 US10273259, Example 740::US10273259, Example 741::US10711020, Example 741 Nuclear receptor ROR-gamma Mus musculus 284 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383029&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678778 404852338 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765641 CNC(=O)CN1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C23H20F8N2O4S/c1-32-19(34)11-33-9-8-20(38(35,36)15-5-3-14(24)4-6-15)16-7-2-13(10-17(16)37-12-18(20)33)21(25,22(26,27)28)23(29,30)31/h2-7,10,18H,8-9,11-12H2,1H3,(H,32,34) QQAIEKOEHZRWSN-UHFFFAOYSA-N 383031 US10273259, Example 742::US10711020, Example 742 Nuclear receptor ROR-gamma Mus musculus 64.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383031&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679230 404852339 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765642 NC(=O)CN1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C22H18F8N2O4S/c23-13-2-4-14(5-3-13)37(34,35)19-7-8-32(10-18(31)33)17(19)11-36-16-9-12(1-6-15(16)19)20(24,21(25,26)27)22(28,29)30/h1-6,9,17H,7-8,10-11H2,(H2,31,33) LCXOZLWBOIWNGY-UHFFFAOYSA-N 383032 US10273259, Example 743::US10711020, Example 743 Nuclear receptor ROR-gamma Mus musculus 84.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383032&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678781 404852340 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765643 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(CC(=O)NCC(F)(F)F)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C25H21F11N2O3S/c26-16-3-5-17(6-4-16)42(40,41)21-9-10-38(12-20(39)37-13-22(27,28)29)19(21)8-1-14-11-15(2-7-18(14)21)23(30,24(31,32)33)25(34,35)36/h2-7,11,19H,1,8-10,12-13H2,(H,37,39)/t19-,21-/m1/s1 SBWYIQHQFWIWNP-TZIWHRDSSA-N 383033 US10273259, Example 744::US10711020, Example 744 Nuclear receptor ROR-gamma Mus musculus 84.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383033&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678916 404852341 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765644 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(CC(=O)NC3CC3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C26H24F8N2O3S/c27-17-3-7-19(8-4-17)40(38,39)23-11-12-36(14-22(37)35-18-5-6-18)21(23)10-1-15-13-16(2-9-20(15)23)24(28,25(29,30)31)26(32,33)34/h2-4,7-9,13,18,21H,1,5-6,10-12,14H2,(H,35,37)/t21-,23-/m1/s1 NQPNRPOIPDEHRU-FYYLOGMGSA-N 383034 US10273259, Example 745::US10711020, Example 745 Nuclear receptor ROR-gamma Mus musculus 150 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383034&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678919 404852342 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765645 CNC(=O)CCN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-34-21(36)10-12-35-13-11-22(39(37,38)18-6-4-17(26)5-7-18)19-8-3-16(14-15(19)2-9-20(22)35)23(27,24(28,29)30)25(31,32)33/h3-8,14,20H,2,9-13H2,1H3,(H,34,36)/t20-,22-/m1/s1 YSFRVCIDCHLBKN-IFMALSPDSA-N 383035 US10273259, Example 746::US10711020, Example 746 Nuclear receptor ROR-gamma Mus musculus 147 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383035&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995610 404852343 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765646 CNC(=O)C(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)c1ccccc1 InChI=1S/C30H26F8N2O3S/c1-39-26(41)25(18-5-3-2-4-6-18)40-16-15-27(44(42,43)22-11-9-21(31)10-12-22)23-13-8-20(17-19(23)7-14-24(27)40)28(32,29(33,34)35)30(36,37)38/h2-6,8-13,17,24-25H,7,14-16H2,1H3,(H,39,41)/t24-,25?,27-/m1/s1 AFNKQJGZJNATFF-PTYBVJFYSA-N 383036 US10273259, Example 747::US10273259, Example 748::US10711020, Example 748 Nuclear receptor ROR-gamma Mus musculus 300 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383036&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995611 404852344 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765647 CNC(=O)C(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)c1ccccc1 InChI=1S/C30H26F8N2O3S/c1-39-26(41)25(18-5-3-2-4-6-18)40-16-15-27(44(42,43)22-11-9-21(31)10-12-22)23-13-8-20(17-19(23)7-14-24(27)40)28(32,29(33,34)35)30(36,37)38/h2-6,8-13,17,24-25H,7,14-16H2,1H3,(H,39,41)/t24-,25?,27-/m1/s1 AFNKQJGZJNATFF-PTYBVJFYSA-N 383036 US10273259, Example 747::US10273259, Example 748::US10711020, Example 748 Nuclear receptor ROR-gamma Mus musculus 542 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383036&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995611 404852344 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765648 CNC(=O)C(C)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-14(21(36)34-2)35-12-11-22(39(37,38)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)35)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,3,10-12H2,1-2H3,(H,34,36)/t14?,20-,22-/m1/s1 VZUREBOIBVKHIF-FRPDIZBGSA-N 383038 US10273259, Example 749::US10273259, Example 750::US10711020, Example 750 Nuclear receptor ROR-gamma Mus musculus 138 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383038&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995612 404852345 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765649 CNC(=O)C(C)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H24F8N2O3S/c1-14(21(36)34-2)35-12-11-22(39(37,38)18-7-5-17(26)6-8-18)19-9-4-16(13-15(19)3-10-20(22)35)23(27,24(28,29)30)25(31,32)33/h4-9,13-14,20H,3,10-12H2,1-2H3,(H,34,36)/t14?,20-,22-/m1/s1 VZUREBOIBVKHIF-FRPDIZBGSA-N 383038 US10273259, Example 749::US10273259, Example 750::US10711020, Example 750 Nuclear receptor ROR-gamma Mus musculus 99.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383038&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995612 404852345 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765650 CNC(=O)C(F)(F)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H22F10N2O3S/c1-36-20(38)22(27,28)13-37-11-10-21(41(39,40)17-6-4-16(26)5-7-17)18-8-3-15(12-14(18)2-9-19(21)37)23(29,24(30,31)32)25(33,34)35/h3-8,12,19H,2,9-11,13H2,1H3,(H,36,38)/t19-,21-/m1/s1 UOVMMNMKAUMCFP-TZIWHRDSSA-N 383040 US10273259, Example 751::US10711020, Example 751 Nuclear receptor ROR-gamma Mus musculus 70.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383040&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995613 404852346 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765651 CNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C24H22F8N2O3S/c1-33-20(35)13-34-11-10-21(38(36,37)17-6-4-16(25)5-7-17)18-8-3-15(12-14(18)2-9-19(21)34)22(26,23(27,28)29)24(30,31)32/h3-8,12,19H,2,9-11,13H2,1H3,(H,33,35)/t19-,21-/m1/s1 NOPYNBZXIYAOSY-TZIWHRDSSA-N 383012 2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)-N-(methyl-d3)acetamide::US10273259, Example 723::US10273259, Example 724::US10273259, Example 752::US10711020, Example 752 Nuclear receptor ROR-gamma Mus musculus 72.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383012&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679257 404852323 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765652 CCC(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)NC InChI=1S/C26H26F8N2O3S/c1-3-20(22(37)35-2)36-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-21(23)36)24(28,25(29,30)31)26(32,33)34/h5-10,14,20-21H,3-4,11-13H2,1-2H3,(H,35,37)/t20?,21-,23-/m1/s1 BLBQMNISGHZKLE-CQQDSARBSA-N 383042 US10273259, Example 753::US10273259, Example 754::US10711020, Example 754 Nuclear receptor ROR-gamma Mus musculus 34.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383042&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995614 404852347 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765653 CCC(N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)NC InChI=1S/C26H26F8N2O3S/c1-3-20(22(37)35-2)36-13-12-23(40(38,39)18-8-6-17(27)7-9-18)19-10-5-16(14-15(19)4-11-21(23)36)24(28,25(29,30)31)26(32,33)34/h5-10,14,20-21H,3-4,11-13H2,1-2H3,(H,35,37)/t20?,21-,23-/m1/s1 BLBQMNISGHZKLE-CQQDSARBSA-N 383042 US10273259, Example 753::US10273259, Example 754::US10711020, Example 754 Nuclear receptor ROR-gamma Mus musculus 75.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383042&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995614 404852347 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765654 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c(F)c1 InChI=1S/C29H22F9NO4S/c30-20-5-7-21(8-6-20)44(42,43)26-11-12-39(15-18-2-1-17(25(40)41)14-23(18)31)24(26)10-3-16-13-19(4-9-22(16)26)27(32,28(33,34)35)29(36,37)38/h1-2,4-9,13-14,24H,3,10-12,15H2,(H,40,41)/t24-,26-/m1/s1 PYCRWQVFXKWUCY-AOYPEHQESA-N 383044 US10273259, Example 755::US10711020, Example 755 Nuclear receptor ROR-gamma Mus musculus 170 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383044&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679106 404852348 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765655 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c(Cl)c1 InChI=1S/C29H22ClF8NO4S/c30-23-14-17(25(40)41)1-2-18(23)15-39-12-11-26(44(42,43)21-7-5-20(31)6-8-21)22-9-4-19(13-16(22)3-10-24(26)39)27(32,28(33,34)35)29(36,37)38/h1-2,4-9,13-14,24H,3,10-12,15H2,(H,40,41)/t24-,26-/m1/s1 PXASGAYFBLUWFN-AOYPEHQESA-N 383045 US10273259, Example 756::US10711020, Example 756 Nuclear receptor ROR-gamma Mus musculus 54.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383045&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679109 404852349 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765656 OC(=O)c1cccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c1 InChI=1S/C29H23F8NO4S/c30-21-6-8-22(9-7-21)43(41,42)26-12-13-38(16-17-2-1-3-19(14-17)25(39)40)24(26)11-4-18-15-20(5-10-23(18)26)27(31,28(32,33)34)29(35,36)37/h1-3,5-10,14-15,24H,4,11-13,16H2,(H,39,40)/t24-,26-/m1/s1 MZALTRIKZNXMQP-AOYPEHQESA-N 383046 US10273259, Example 757::US10711020, Example 757 Nuclear receptor ROR-gamma Mus musculus 48.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383046&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679260 404852350 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765657 COc1cc(ccc1CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H25F8NO5S/c1-44-24-15-18(26(40)41)2-3-19(24)16-39-13-12-27(45(42,43)22-8-6-21(31)7-9-22)23-10-5-20(14-17(23)4-11-25(27)39)28(32,29(33,34)35)30(36,37)38/h2-3,5-10,14-15,25H,4,11-13,16H2,1H3,(H,40,41)/t25-,27-/m1/s1 IMCOLAVLXWJYDN-XNMGPUDCSA-N 383047 US10273259, Example 758::US10711020, Example 758 Nuclear receptor ROR-gamma Mus musculus 87.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383047&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678731 404852351 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765658 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)c(c1)C(O)=O InChI=1S/C30H23F8NO6S/c31-20-5-7-21(8-6-20)46(44,45)27-11-12-39(15-18-2-1-17(25(40)41)14-22(18)26(42)43)24(27)10-3-16-13-19(4-9-23(16)27)28(32,29(33,34)35)30(36,37)38/h1-2,4-9,13-14,24H,3,10-12,15H2,(H,40,41)(H,42,43)/t24-,27-/m1/s1 FNBSWLNILHSTGZ-SHQCIBLASA-N 383048 US10273259, Example 759::US10711020, Example 759 Nuclear receptor ROR-gamma Mus musculus 107 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383048&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678772 404852352 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765659 CC(=O)N1CCC(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)CC1 InChI=1S/C29H30F8N2O3S/c1-18(40)38-13-10-19(11-14-38)17-39-15-12-26(43(41,42)23-6-4-22(30)5-7-23)24-8-3-21(16-20(24)2-9-25(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,19,25H,2,9-15,17H2,1H3/t25-,26-/m1/s1 QVUOIGWWVITMCJ-CLJLJLNGSA-N 383049 1-(4-(((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methyl)piperidin-1-yl)ethan-1-one::US10273259, Example 760::US10711020, Example 760 Nuclear receptor ROR-gamma Mus musculus 119 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383049&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669220 404852353 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765660 Cn1ncnc1CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H22F8N4O2S/c1-36-21(34-14-35-36)13-37-11-10-22(40(38,39)18-6-4-17(26)5-7-18)19-8-3-16(12-15(19)2-9-20(22)37)23(27,24(28,29)30)25(31,32)33/h3-8,12,14,20H,2,9-11,13H2,1H3/t20-,22-/m1/s1 IBODDIAQDDHORD-IFMALSPDSA-N 383050 (3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-3-((1-methyl-1H-1,2,4-triazol-5-yl)methyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole::US10273259, Example 761::US10711020, Example 761 Nuclear receptor ROR-gamma Mus musculus 112 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383050&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669195 404852354 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765661 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(Cc3ncc[nH]3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F 383051 US10273259, Example 762::US10711020, Example 762 Nuclear receptor ROR-gamma Mus musculus 309 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383051&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679158 404852355 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765662 Cn1ccnc1CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H23F8N3O2S/c1-36-13-11-35-22(36)15-37-12-10-23(40(38,39)19-6-4-18(27)5-7-19)20-8-3-17(14-16(20)2-9-21(23)37)24(28,25(29,30)31)26(32,33)34/h3-8,11,13-14,21H,2,9-10,12,15H2,1H3/t21-,23-/m1/s1 VKWYORZIUYAHCX-FYYLOGMGSA-N 383052 US10273259, Example 763::US10711020, Example 763 Nuclear receptor ROR-gamma Mus musculus 109 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383052&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679281 404852356 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765663 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(Cc3nnn[nH]3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F 383053 US10273259, Example 764::US10711020, Example 764 Nuclear receptor ROR-gamma Mus musculus 687 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383053&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995615 404852357 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765664 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1 InChI=1S/C29H23F8NO4S/c30-21-7-9-22(10-8-21)43(41,42)26-13-14-38(16-17-1-3-18(4-2-17)25(39)40)24(26)12-5-19-15-20(6-11-23(19)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,24H,5,12-14,16H2,(H,39,40)/t24-,26-/m1/s1 XAEAXIOTEFFAIN-AOYPEHQESA-N 383054 US10273259, Example 765::US10711020, Example 765 Nuclear receptor ROR-gamma Mus musculus 208 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383054&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679267 404852358 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765665 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(Cc3ccc(C#N)c(F)c3)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C29H21F9N2O2S/c30-21-5-7-22(8-6-21)43(41,42)26-11-12-40(16-17-1-2-19(15-39)24(31)13-17)25(26)10-3-18-14-20(4-9-23(18)26)27(32,28(33,34)35)29(36,37)38/h1-2,4-9,13-14,25H,3,10-12,16H2/t25-,26-/m1/s1 QWGXMGGFEJKXGH-CLJLJLNGSA-N 383055 US10273259, Example 766::US10711020, Example 766 Nuclear receptor ROR-gamma Mus musculus 1348 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383055&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678921 404852359 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765666 OC(=O)c1ccccc1CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H23F8NO4S/c30-20-7-9-21(10-8-20)43(41,42)26-13-14-38(16-18-3-1-2-4-22(18)25(39)40)24(26)12-5-17-15-19(6-11-23(17)26)27(31,28(32,33)34)29(35,36)37/h1-4,6-11,15,24H,5,12-14,16H2,(H,39,40)/t24-,26-/m1/s1 ODQKPIKTNBRZHQ-AOYPEHQESA-N 383056 US10273259, Example 767::US10711020, Example 767 Nuclear receptor ROR-gamma Mus musculus 91.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383056&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678766 404852360 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765667 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1F InChI=1S/C29H22F9NO4S/c30-19-4-6-20(7-5-19)44(42,43)26-11-12-39(15-16-1-8-21(25(40)41)23(31)13-16)24(26)10-2-17-14-18(3-9-22(17)26)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,40,41)/t24-,26-/m1/s1 VJGMLZZPOBQQHX-AOYPEHQESA-N 383057 US10273259, Example 768::US10711020, Example 768 Nuclear receptor ROR-gamma Mus musculus 291 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383057&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678789 404852361 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765668 OC(=O)c1ccc(CN2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)cc1Cl InChI=1S/C29H22ClF8NO4S/c30-23-13-16(1-8-21(23)25(40)41)15-39-12-11-26(44(42,43)20-6-4-19(31)5-7-20)22-9-3-18(14-17(22)2-10-24(26)39)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,24H,2,10-12,15H2,(H,40,41)/t24-,26-/m1/s1 FJYXVQNSINUYKK-AOYPEHQESA-N 383058 US10273259, Example 769::US10711020, Example 769 Nuclear receptor ROR-gamma Mus musculus 117 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383058&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678758 404852362 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765669 OC(=O)CN1C2CCc3cc(I)ccc3C2(CC1=O)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C20H17FINO5S/c21-13-2-5-15(6-3-13)29(27,28)20-10-18(24)23(11-19(25)26)17(20)8-1-12-9-14(22)4-7-16(12)20/h2-7,9,17H,1,8,10-11H2,(H,25,26) WDXLKIBSCQMVPW-UHFFFAOYSA-N 383059 9b-((4-fluorophenyl)sulfonyl)-7-iodo-2-oxo-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)acetic acid::US10273259, Example 770::US10711020, Example 770 Nuclear receptor ROR-gamma Mus musculus 9197 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383059&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669257 404852363 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765670 CN1CCC2(C1CN(C)c1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C22H20F8N2O2S/c1-31-10-9-19(35(33,34)15-6-4-14(23)5-7-15)16-8-3-13(11-17(16)32(2)12-18(19)31)20(24,21(25,26)27)22(28,29)30/h3-8,11,18H,9-10,12H2,1-2H3 LAYZEJQWHLQYCR-UHFFFAOYSA-N 383060 9b-((4-fluorophenyl)sulfonyl)-35-dimethyl-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-c]quinolone::US10273259, Example 771::US10711020, Example 771 Nuclear receptor ROR-gamma Mus musculus 157 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383060&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669044 404852364 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765671 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C27H21F8NO2S/c28-19-8-10-21(11-9-19)39(37,38)24-14-15-36(20-4-2-1-3-5-20)23(24)13-6-17-16-18(7-12-22(17)24)25(29,26(30,31)32)27(33,34)35/h1-5,7-12,16,23H,6,13-15H2/t23-,24-/m1/s1 VLTICJRVEWWLEX-DNQXCXABSA-N 383061 (3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-3-phenyl-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole::US10273259, Example 772::US10711020, Example 772 Nuclear receptor ROR-gamma Mus musculus 609 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383061&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669249 404852365 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765672 OC(=O)c1ccc(cc1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H21F8NO4S/c29-19-5-9-21(10-6-19)42(40,41)25-13-14-37(20-7-1-16(2-8-20)24(38)39)23(25)12-3-17-15-18(4-11-22(17)25)26(30,27(31,32)33)28(34,35)36/h1-2,4-11,15,23H,3,12-14H2,(H,38,39)/t23-,25-/m1/s1 CFYBAAUCYHKAOS-ILBGXUMGSA-N 383062 4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)benzoic acid::US10273259, Example 773::US10711020, Example 773 Nuclear receptor ROR-gamma Mus musculus 1801 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383062&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669122 404852366 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765673 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ccccn1 InChI=1S/C26H20F8N2O2S/c27-18-6-8-19(9-7-18)39(37,38)23-12-14-36(22-3-1-2-13-35-22)21(23)11-4-16-15-17(5-10-20(16)23)24(28,25(29,30)31)26(32,33)34/h1-3,5-10,13,15,21H,4,11-12,14H2/t21-,23-/m1/s1 ZEAXVASESOSYJP-FYYLOGMGSA-N 383063 (3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-3-(pyridin-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole::US10273259, Example 774::US10711020, Example 774 Nuclear receptor ROR-gamma Mus musculus 679 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383063&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669140 404852367 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765674 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ccccc1F InChI=1S/C27H20F9NO2S/c28-18-7-9-19(10-8-18)40(38,39)24-13-14-37(22-4-2-1-3-21(22)29)23(24)12-5-16-15-17(6-11-20(16)24)25(30,26(31,32)33)27(34,35)36/h1-4,6-11,15,23H,5,12-14H2/t23-,24-/m1/s1 UVFZYKMNWWAUHO-DNQXCXABSA-N 383064 US10273259, Example 775::US10711020, Example 775 Nuclear receptor ROR-gamma Mus musculus 534 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383064&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679174 404852368 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765675 OC(=O)c1cccc(c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H21F8NO4S/c29-19-6-8-21(9-7-19)42(40,41)25-12-13-37(20-3-1-2-17(15-20)24(38)39)23(25)11-4-16-14-18(5-10-22(16)25)26(30,27(31,32)33)28(34,35)36/h1-3,5-10,14-15,23H,4,11-13H2,(H,38,39)/t23-,25-/m1/s1 LHVUXKYHVZPDMP-ILBGXUMGSA-N 383065 US10273259, Example 776::US10711020, Example 776 Nuclear receptor ROR-gamma Mus musculus 1490 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383065&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678915 404852369 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765676 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1cccnc1 InChI=1S/C26H20F8N2O2S/c27-18-5-7-20(8-6-18)39(37,38)23-11-13-36(19-2-1-12-35-15-19)22(23)10-3-16-14-17(4-9-21(16)23)24(28,25(29,30)31)26(32,33)34/h1-2,4-9,12,14-15,22H,3,10-11,13H2/t22-,23-/m1/s1 CLHCWIIGEYZMFU-DHIUTWEWSA-N 383066 US10273259, Example 777::US10711020, Example 777 Nuclear receptor ROR-gamma Mus musculus 493 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383066&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679164 404852370 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765677 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ccnnc1 InChI=1S/C25H19F8N3O2S/c26-17-3-5-19(6-4-17)39(37,38)22-10-12-36(18-9-11-34-35-14-18)21(22)8-1-15-13-16(2-7-20(15)22)23(27,24(28,29)30)25(31,32)33/h2-7,9,11,13-14,21H,1,8,10,12H2/t21-,22-/m1/s1 RIYFFVQPAHUUTF-FGZHOGPDSA-N 383067 US10273259, Example 778::US10711020, Example 778 Nuclear receptor ROR-gamma Mus musculus 171 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383067&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679277 404852371 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765678 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1cccnn1 InChI=1S/C25H19F8N3O2S/c26-17-5-7-18(8-6-17)39(37,38)22-11-13-36(21-2-1-12-34-35-21)20(22)10-3-15-14-16(4-9-19(15)22)23(27,24(28,29)30)25(31,32)33/h1-2,4-9,12,14,20H,3,10-11,13H2/t20-,22-/m1/s1 FLRNTNCTFKBARE-IFMALSPDSA-N 383068 US10273259, Example 779::US10711020, Example 779 Nuclear receptor ROR-gamma Mus musculus 283 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383068&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678795 404852372 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765679 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1cncnc1 InChI=1S/C25H19F8N3O2S/c26-17-3-5-19(6-4-17)39(37,38)22-9-10-36(18-12-34-14-35-13-18)21(22)8-1-15-11-16(2-7-20(15)22)23(27,24(28,29)30)25(31,32)33/h2-7,11-14,21H,1,8-10H2/t21-,22-/m1/s1 UVXMBBAZSDTQSU-FGZHOGPDSA-N 383069 US10273259, Example 780::US10711020, Example 780 Nuclear receptor ROR-gamma Mus musculus 97.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383069&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679178 404852373 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765680 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1cnccn1 InChI=1S/C25H19F8N3O2S/c26-17-3-5-18(6-4-17)39(37,38)22-9-12-36(21-14-34-10-11-35-21)20(22)8-1-15-13-16(2-7-19(15)22)23(27,24(28,29)30)25(31,32)33/h2-7,10-11,13-14,20H,1,8-9,12H2/t20-,22-/m1/s1 JBISLVMOEUMVIA-IFMALSPDSA-N 383070 US10273259, Example 781::US10711020, Example 781 Nuclear receptor ROR-gamma Mus musculus 913 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383070&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679163 404852374 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765681 CS(=O)(=O)c1ccc(cc1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H23F8NO4S2/c1-42(38,39)21-10-6-20(7-11-21)37-15-14-25(43(40,41)22-8-4-19(29)5-9-22)23-12-3-18(16-17(23)2-13-24(25)37)26(30,27(31,32)33)28(34,35)36/h3-12,16,24H,2,13-15H2,1H3/t24-,25-/m1/s1 VWHOERRGZINANJ-JWQCQUIFSA-N 383071 US10273259, Example 782::US10711020, Example 782 Nuclear receptor ROR-gamma Mus musculus 148 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383071&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679176 404852375 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765682 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)c1ncccn1 InChI=1S/C25H19F8N3O2S/c26-17-4-6-18(7-5-17)39(37,38)22-10-13-36(21-34-11-1-12-35-21)20(22)9-2-15-14-16(3-8-19(15)22)23(27,24(28,29)30)25(31,32)33/h1,3-8,11-12,14,20H,2,9-10,13H2/t20-,22-/m1/s1 IBWPTNJDHOEHGP-IFMALSPDSA-N 383072 US10273259, Example 783::US10711020, Example 783 Nuclear receptor ROR-gamma Mus musculus 507 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383072&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679173 404852376 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765683 CS(=O)(=O)c1cccc(c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H23F8NO4S2/c1-42(38,39)22-4-2-3-20(16-22)37-14-13-25(43(40,41)21-9-7-19(29)8-10-21)23-11-6-18(15-17(23)5-12-24(25)37)26(30,27(31,32)33)28(34,35)36/h2-4,6-11,15-16,24H,5,12-14H2,1H3/t24-,25-/m1/s1 TWZOUPREUPGMLE-JWQCQUIFSA-N 383073 US10273259, Example 784::US10711020, Example 784 Nuclear receptor ROR-gamma Mus musculus 154 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383073&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678904 404852377 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765684 Cn1nnc(n1)-c1ccc(cc1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H23F8N5O2S/c1-41-39-25(38-40-41)17-2-8-21(9-3-17)42-15-14-26(45(43,44)22-10-6-20(30)7-11-22)23-12-5-19(16-18(23)4-13-24(26)42)27(31,28(32,33)34)29(35,36)37/h2-3,5-12,16,24H,4,13-15H2,1H3/t24-,26-/m1/s1 YRGRBAUVKSBUAL-AOYPEHQESA-N 383074 US10273259, Example 785::US10711020, Example 785 Nuclear receptor ROR-gamma Mus musculus 3199 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383074&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679255 404852378 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765685 OC(=O)C1(CC1)c1ccc(cc1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H25F8NO4S/c32-21-5-9-23(10-6-21)45(43,44)28-15-16-40(22-7-2-19(3-8-22)27(13-14-27)26(41)42)25(28)12-1-18-17-20(4-11-24(18)28)29(33,30(34,35)36)31(37,38)39/h2-11,17,25H,1,12-16H2,(H,41,42)/t25-,28-/m1/s1 FWGHZTYTFDGARE-LEAFIULHSA-N 383075 US10273259, Example 786::US10711020, Example 786 Nuclear receptor ROR-gamma Mus musculus 1441 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383075&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679179 404852379 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765686 CN(C)S(=O)(=O)c1cccc(c1)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26F8N2O4S2/c1-38(2)45(42,43)23-5-3-4-21(17-23)39-15-14-26(44(40,41)22-10-8-20(30)9-11-22)24-12-7-19(16-18(24)6-13-25(26)39)27(31,28(32,33)34)29(35,36)37/h3-5,7-12,16-17,25H,6,13-15H2,1-2H3/t25-,26-/m1/s1 XKXZXGYMMFLYBM-CLJLJLNGSA-N 383076 US10273259, Example 787::US10711020, Example 787 Nuclear receptor ROR-gamma Mus musculus 4311 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383076&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679287 404852380 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765687 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN(C#N)[C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C22H16F8N2O2S/c23-15-3-5-16(6-4-15)35(33,34)19-9-10-32(12-31)18(19)8-1-13-11-14(2-7-17(13)19)20(24,21(25,26)27)22(28,29)30/h2-7,11,18H,1,8-10H2/t18-,19-/m1/s1 BCMPTGHPPKHMIV-RTBURBONSA-N 383077 (3aR,9bR)-9b-((4-fluorophenyl)sulfon)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonitrile::US10273259, Example 788::US10711020, Example 788 Nuclear receptor ROR-gamma Mus musculus 98.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383077&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669246 404852381 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765688 CC(C)(C)OC(=O)N1CC2N(CCC2(c2ccc(cc12)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C33H34F8N2O7S/c1-29(2,3)50-28(47)43-17-25-30(51(48,49)22-11-9-21(34)10-12-22,14-15-42(25)26(44)18-4-6-19(7-5-18)27(45)46)23-13-8-20(16-24(23)43)31(35,32(36,37)38)33(39,40)41/h8-13,16,18-19,25H,4-7,14-15,17H2,1-3H3,(H,45,46)/t18-,19-,25?,30? FVIRJSMDLMJNNB-MZYLFTCCSA-N 383078 (1r,4r)-4-(5-(tert-butoxycarbonyl)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[2,3-c]quinoline-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 789::US10711020, Example 789 Nuclear receptor ROR-gamma Mus musculus 1866 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383078&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669267 404852382 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765689 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(CC(F)(F)F)ccc21)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C28H29ClF3NO5S/c29-21-7-9-22(10-8-21)39(37,38)27-13-14-33(25(34)18-2-4-19(5-3-18)26(35)36)24(27)12-6-20-15-17(1-11-23(20)27)16-28(30,31)32/h1,7-11,15,18-19,24H,2-6,12-14,16H2,(H,35,36)/t18-,19-,24?,27? CJQMXTYGUBQBSQ-QXIWJBPRSA-N 383079 (1r,4r)-4-(9b-((4-chlorophenyl)sulfonyl)-7-(perfluoropropyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 790::US10711020, Example 790 Nuclear receptor ROR-gamma Mus musculus 41.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383079&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995616 404852383 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765690 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C29H27ClF7NO5S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-38(24(39)16-1-3-17(4-2-16)25(40)41)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h6-11,15-17,23H,1-5,12-14H2,(H,40,41)/t16-,17-,23?,26? ASSZTGFDWPKORU-LRVXPCDCSA-N 383080 (1r,4r)-4-(9b-((4-chlorophenyl)sulfonyl)-7-(1,1,2,2-tetrafluoroethyl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 791 Nuclear receptor ROR-gamma Mus musculus 78.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383080&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669076 404852384 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765691 OC(=O)C12CCC(CC1)(CC2)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C#N InChI=1S/C32H29F7N2O5S/c33-30(31(34,35)36,32(37,38)39)21-4-7-23-20(17-21)3-8-24-29(23,47(45,46)22-5-1-19(18-40)2-6-22)15-16-41(24)25(42)27-9-12-28(13-10-27,14-11-27)26(43)44/h1-2,4-7,17,24H,3,8-16H2,(H,43,44) OXYFHDCLZCGNPN-UHFFFAOYSA-N 383081 4-(9b-((4-cyanophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,59b-hexahydro-1H-benzo[e]indole-3-carbonyl)bicyclo[2.2.2]octane-1-carboxylic acid::US10273259, Example 792::US10711020, Example 792 Nuclear receptor ROR-gamma Mus musculus 186 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383081 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383081&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669179 404852385 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765692 CN(C)c1ccc(cc1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C12CCC(CC1)(CC2)C(O)=O InChI=1S/C33H35F7N2O5S/c1-41(2)22-5-7-23(8-6-22)48(46,47)30-17-18-42(26(43)28-11-14-29(15-12-28,16-13-28)27(44)45)25(30)10-3-20-19-21(4-9-24(20)30)31(34,32(35,36)37)33(38,39)40/h4-9,19,25H,3,10-18H2,1-2H3,(H,44,45) VFPOHKRGMQNWSJ-UHFFFAOYSA-N 383082 4-(9b-((4-(dimethylamino)phenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)bicyclo[2.2.2]octane-1-carboxylic acid::US10273259, Example 793::US10711020, Example 793 Nuclear receptor ROR-gamma Mus musculus 398 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383082&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669116 404852386 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765693 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)-c1cnoc1 InChI=1S/C32H29F7N2O6S/c33-30(31(34,35)36,32(37,38)39)23-8-11-25-21(15-23)7-12-26-29(25,13-14-41(26)27(42)19-1-3-20(4-2-19)28(43)44)48(45,46)24-9-5-18(6-10-24)22-16-40-47-17-22/h5-6,8-11,15-17,19-20,26H,1-4,7,12-14H2,(H,43,44)/t19-,20-,26?,29? QQGUOZSVFBDLOO-IWULTPLFSA-N 383083 (1r,4r)-4-(9b-((4-(isoxazol-4-yl)phenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 794::US10711020, Example 794 Nuclear receptor ROR-gamma Mus musculus 566 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383083&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669056 404852387 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765694 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(cc1)-c1cn[nH]c1 383084 (1r,4r)-4-(9b-((4-(1H-pyrazol-4-yl)phenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 795::US10711020, Example 795 Nuclear receptor ROR-gamma Mus musculus 2382 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383084&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669175 404852388 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765695 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(c1)C1CC1 InChI=1S/C32H32F7NO5S/c33-30(31(34,35)36,32(37,38)39)23-11-12-25-22(16-23)10-13-26-29(25,46(44,45)24-3-1-2-21(17-24)18-4-5-18)14-15-40(26)27(41)19-6-8-20(9-7-19)28(42)43/h1-3,11-12,16-20,26H,4-10,13-15H2,(H,42,43)/t19-,20-,26?,29? FFVQQGOYYNBWJR-IWULTPLFSA-N 383085 (1r,4r)-4-(9b-((3-cyclopropylphenyl)sulfon)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 796::US10711020, Example 796 Nuclear receptor ROR-gamma Mus musculus 100.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383085&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669082 404852389 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765696 CC(C)c1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C32H34F7NO5S/c1-18(2)21-4-3-5-24(17-21)46(44,45)29-14-15-40(27(41)19-6-8-20(9-7-19)28(42)43)26(29)13-10-22-16-23(11-12-25(22)29)30(33,31(34,35)36)32(37,38)39/h3-5,11-12,16-20,26H,6-10,13-15H2,1-2H3,(H,42,43)/t19-,20-,26?,29? KZUNTLQUEAKZJR-IWULTPLFSA-N 383086 US10273259, Example 797::US10711020, Example 797 Nuclear receptor ROR-gamma Mus musculus 136 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383086&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679169 404852390 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765697 CC(C)(C)c1cccc(c1)S(=O)(=O)C12CCN(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1CC[C@@H](CC1)C(O)=O InChI=1S/C33H36F7NO5S/c1-29(2,3)22-5-4-6-24(18-22)47(45,46)30-15-16-41(27(42)19-7-9-20(10-8-19)28(43)44)26(30)14-11-21-17-23(12-13-25(21)30)31(34,32(35,36)37)33(38,39)40/h4-6,12-13,17-20,26H,7-11,14-16H2,1-3H3,(H,43,44)/t19-,20-,26?,30? ZQQMASTWINYCKW-XZJQCRQJSA-N 383087 US10273259, Example 798::US10711020, Example 798 Nuclear receptor ROR-gamma Mus musculus 167 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383087&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679155 404852391 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765698 C[C@@]1(CC[C@@H](CC1)C(N)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O4S/c1-26(12-10-17(11-13-26)24(39)41)25(42)40-15-14-27(45(43,44)21-6-4-20(31)5-7-21)22-8-3-19(16-18(22)2-9-23(27)40)28(32,29(33,34)35)30(36,37)38/h3-8,16-17,23H,2,9-15H2,1H3,(H2,39,41)/t17-,23-,26-,27-/m1/s1 ONFZNJMYTDFRQY-ZKPUSUNFSA-N 383088 (1R,4r)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-4-methylcyclohexanecarboxamide::US10273259, Example 799::US10711020, Example 799 Nuclear receptor ROR-gamma Mus musculus 151 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383088&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669251 404852392 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765699 NC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O4S/c30-20-7-9-21(10-8-20)44(42,43)26-13-14-39(25(41)17-3-1-16(2-4-17)24(38)40)23(26)12-5-18-15-19(6-11-22(18)26)27(31,28(32,33)34)29(35,36)37/h6-11,15-17,23H,1-5,12-14H2,(H2,38,40)/t16-,17-,23-,26-/m1/s1 PNTPXUODWXXURV-NIULTJEISA-N 383089 US10273259, Example 800::US10711020, Example 800 Nuclear receptor ROR-gamma Mus musculus 612 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383089&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678818 404852393 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765700 NC(=O)C12CCC(CC1)(CC2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H30F8N2O4S/c32-20-3-5-21(6-4-20)46(44,45)28-15-16-41(25(43)27-12-9-26(10-13-27,11-14-27)24(40)42)23(28)8-1-18-17-19(2-7-22(18)28)29(33,30(34,35)36)31(37,38)39/h2-7,17,23H,1,8-16H2,(H2,40,42)/t23-,26?,27?,28-/m1/s1 JSBIURSSLBILKU-LJJHVHFXSA-N 383090 US10273259, Example 801::US10711020, Example 801 Nuclear receptor ROR-gamma Mus musculus 23.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383090&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678798 404852394 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765701 OC(=O)CNC(=O)CN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C25H22F8N2O5S/c26-16-3-5-17(6-4-16)41(39,40)22-9-10-35(13-20(36)34-12-21(37)38)19(22)8-1-14-11-15(2-7-18(14)22)23(27,24(28,29)30)25(31,32)33/h2-7,11,19H,1,8-10,12-13H2,(H,34,36)(H,37,38)/t19-,22-/m1/s1 XUMHQYDIOXEKGF-DENIHFKCSA-N 383091 (2-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)acetyl)glycine::US10273259, Example 802::US10711020, Example 802 Nuclear receptor ROR-gamma Mus musculus 45.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383091&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669102 404852395 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765702 CC(=O)N1[C@H]2CC[C@@H]1C[C@H](C2)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C31H30F8N2O4S/c1-17(42)41-22-6-7-23(41)16-19(15-22)27(43)40-13-12-28(46(44,45)24-8-4-21(32)5-9-24)25-10-3-20(14-18(25)2-11-26(28)40)29(33,30(34,35)36)31(37,38)39/h3-5,8-10,14,19,22-23,26H,2,6-7,11-13,15-16H2,1H3/t19-,22-,23+,26-,28-/m1/s1 XOTKCPPJYNDQNN-GBBRFOGASA-N 383092 1-((1R,3s,5S)-3-((3aR,9bR)-9b-((4-fluorophenyl)sulfon-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-8-azabicyclo[3.2.1]octan-8-yl)ethan-1-one::US10273259, Example 803::US10711020, Example 803 Nuclear receptor ROR-gamma Mus musculus 73.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383092&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669050 404852396 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765703 CC1(CCN(CC1)S(C)(=O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H30F8N2O5S2/c1-25(11-14-38(15-12-25)45(2,41)42)24(40)39-16-13-26(46(43,44)21-7-5-20(30)6-8-21)22-9-4-19(17-18(22)3-10-23(26)39)27(31,28(32,33)34)29(35,36)37/h4-9,17,23H,3,10-16H2,1-2H3/t23-,26-/m1/s1 HMQAYZVGFYBODV-ZEQKJWHPSA-N 383093 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(4-methyl-1-(methylsulfonyl)piperidin-4-yl)methanone::US10273259, Example 804::US10711020, Example 804 Nuclear receptor ROR-gamma Mus musculus 88.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383093&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669204 404852397 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765704 CS(=O)(=O)N1CC[C@H](CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C28H28F8N2O5S2/c1-44(40,41)37-12-10-17(16-37)14-24(39)38-13-11-25(45(42,43)21-6-4-20(29)5-7-21)22-8-3-19(15-18(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,15,17,23H,2,9-14,16H2,1H3/t17-,23-,25-/m1/s1 JVGBYMCNHUKIJC-WQWSHVPRSA-N 383094 US10273259, Example 805::US10711020, Example 805 Nuclear receptor ROR-gamma Mus musculus 88.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383094&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679193 404852398 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765705 CC(=O)N1CC[C@H](CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C29H28F8N2O4S/c1-17(40)38-12-10-18(16-38)14-25(41)39-13-11-26(44(42,43)22-6-4-21(30)5-7-22)23-8-3-20(15-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,15,18,24H,2,9-14,16H2,1H3/t18-,24-,26-/m1/s1 YPQKOUHFNCTHTI-DETVKUJNSA-N 383095 US10273259, Example 806::US10711020, Example 806 Nuclear receptor ROR-gamma Mus musculus 145 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383095&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678933 404852399 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765706 CS(=O)(=O)N1CC[C@@H](CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C28H28F8N2O5S2/c1-44(40,41)37-12-10-17(16-37)14-24(39)38-13-11-25(45(42,43)21-6-4-20(29)5-7-21)22-8-3-19(15-18(22)2-9-23(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,15,17,23H,2,9-14,16H2,1H3/t17-,23+,25+/m0/s1 JVGBYMCNHUKIJC-FIMBPPNMSA-N 383096 US10273259, Example 807::US10711020, Example 807 Nuclear receptor ROR-gamma Mus musculus 283 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383096&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679270 404852400 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765707 CC(=O)N1CC[C@@H](CC(=O)N2CC[C@@]3([C@H]2CCc2cc(ccc32)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c2ccc(F)cc2)C1 InChI=1S/C29H28F8N2O4S/c1-17(40)38-12-10-18(16-38)14-25(41)39-13-11-26(44(42,43)22-6-4-21(30)5-7-22)23-8-3-20(15-19(23)2-9-24(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,15,18,24H,2,9-14,16H2,1H3/t18-,24+,26+/m0/s1 YPQKOUHFNCTHTI-GJECAEJISA-N 383097 US10273259, Example 808::US10711020, Example 808 Nuclear receptor ROR-gamma Mus musculus 107 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383097&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679297 404852401 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765708 CNC(=O)N1CCC(O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O5S/c1-38-24(42)39-13-10-25(43,11-14-39)23(41)40-15-12-26(46(44,45)20-6-4-19(30)5-7-20)21-8-3-18(16-17(21)2-9-22(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,16,22,43H,2,9-15H2,1H3,(H,38,42)/t22-,26-/m1/s1 XFOCXZOXBPQBPJ-ATIYNZHBSA-N 383098 US10273259, Example 809::US10711020, Example 809 Nuclear receptor ROR-gamma Mus musculus 25.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383098&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679189 404852402 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765709 CC(=O)N1CCC(O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O5S/c1-17(40)38-13-10-25(42,11-14-38)24(41)39-15-12-26(45(43,44)21-6-4-20(30)5-7-21)22-8-3-19(16-18(22)2-9-23(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,23,42H,2,9-15H2,1H3/t23-,26-/m1/s1 KRNPISDXRCLWSC-ZEQKJWHPSA-N 383099 US10273259, Example 810::US10711020, Example 810 Nuclear receptor ROR-gamma Mus musculus 50.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383099&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678813 404852403 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765710 CS(=O)(=O)N1CCC(O)(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C28H28F8N2O6S2/c1-45(41,42)37-13-10-24(40,11-14-37)23(39)38-15-12-25(46(43,44)20-6-4-19(29)5-7-20)21-8-3-18(16-17(21)2-9-22(25)38)26(30,27(31,32)33)28(34,35)36/h3-8,16,22,40H,2,9-15H2,1H3/t22-,25-/m1/s1 GSKNAEWYNISDFT-RCZVLFRGSA-N 383100 US10273259, Example 811::US10711020, Example 811 Nuclear receptor ROR-gamma Mus musculus 23.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383100&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679153 404852404 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765711 CNC(=O)N1CCC(CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O4S/c1-38-25(42)39-13-10-17(11-14-39)24(41)40-15-12-26(45(43,44)21-6-4-20(30)5-7-21)22-8-3-19(16-18(22)2-9-23(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,16-17,23H,2,9-15H2,1H3,(H,38,42)/t23-,26-/m1/s1 PJIGGRYGFXGPOU-ZEQKJWHPSA-N 383101 US10273259, Example 812::US10711020, Example 812 Nuclear receptor ROR-gamma Mus musculus 195 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383101&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678777 404852405 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765712 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C#N InChI=1S/C28H25F8N3O3S/c29-20-3-5-21(6-4-20)43(41,42)25-11-14-39(24(40)17-9-12-38(16-37)13-10-17)23(25)8-1-18-15-19(2-7-22(18)25)26(30,27(31,32)33)28(34,35)36/h2-7,15,17,23H,1,8-14H2/t23-,25-/m1/s1 YQTJHRVUUFXQJE-ILBGXUMGSA-N 383102 4-((3a,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)piperidine-1-carbonitrile::US10273259, Example 813::US10711020, Example 813 Nuclear receptor ROR-gamma Mus musculus 115 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383102&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669112 404852406 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765713 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1CCN(CC1)C1COC1 InChI=1S/C30H30F8N2O4S/c31-21-3-5-23(6-4-21)45(42,43)27-11-14-40(26(41)18-9-12-39(13-10-18)22-16-44-17-22)25(27)8-1-19-15-20(2-7-24(19)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,18,22,25H,1,8-14,16-17H2/t25-,27-/m1/s1 NZJVRFQYGIPLQK-XNMGPUDCSA-N 383103 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(1-(oxetan-3-yl)piperidin-4-yl)methanone::US10273259, Example 814::US10711020, Example 814 Nuclear receptor ROR-gamma Mus musculus 125 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383103&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669219 404852407 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765714 OC1(CCN(CC1)C1COC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H30F8N2O5S/c31-20-3-5-22(6-4-20)46(43,44)27-11-14-40(25(41)26(42)9-12-39(13-10-26)21-16-45-17-21)24(27)8-1-18-15-19(2-7-23(18)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,21,24,42H,1,8-14,16-17H2/t24-,27-/m1/s1 BDFQXHHQFBKLKW-SHQCIBLASA-N 383104 US10273259, Example 815::US10711020, Example 815 Nuclear receptor ROR-gamma Mus musculus 18.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383104&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679299 404852408 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765715 FC(F)(F)C(F)(c1ccc2c(CCC3N(CCC23S(=O)(=O)c2ccc(Cl)cc2)C(=O)C2CCN(CC2)C2COC2)c1)C(F)(F)F InChI=1S/C30H30ClF7N2O4S/c31-21-3-5-23(6-4-21)45(42,43)27-11-14-40(26(41)18-9-12-39(13-10-18)22-16-44-17-22)25(27)8-1-19-15-20(2-7-24(19)27)28(32,29(33,34)35)30(36,37)38/h2-7,15,18,22,25H,1,8-14,16-17H2 DNCYFVCXNBPWBR-UHFFFAOYSA-N 383105 US10273259, Example 816::US10711020, Example 816 Nuclear receptor ROR-gamma Mus musculus 105 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383105&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679184 404852409 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765716 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)[C@H]1C[C@@H]2CC[C@H](C1)N2C1COC1 InChI=1S/C32H32F8N2O4S/c33-21-3-7-25(8-4-21)47(44,45)29-11-12-41(28(43)19-14-22-5-6-23(15-19)42(22)24-16-46-17-24)27(29)10-1-18-13-20(2-9-26(18)29)30(34,31(35,36)37)32(38,39)40/h2-4,7-9,13,19,22-24,27H,1,5-6,10-12,14-17H2/t19-,22-,23+,27-,29-/m1/s1 XCZUUBDKYSLWSI-VYYHNUKQSA-N 383106 US10273259, Example 817::US10711020, Example 817 Nuclear receptor ROR-gamma Mus musculus 601 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383106&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679123 404852410 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765717 C[C@H]1CN(CCN1CC(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H29F8N3O5S/c1-17-15-39(13-12-38(17)16-24(41)42)25(43)40-11-10-26(46(44,45)21-6-4-20(30)5-7-21)22-8-3-19(14-18(22)2-9-23(26)40)27(31,28(32,33)34)29(35,36)37/h3-8,14,17,23H,2,9-13,15-16H2,1H3,(H,41,42)/t17-,23+,26+/m0/s1 AZOCQYRFZPNTLU-UIIQVKDUSA-N 383107 2-((S)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylpiperazin-1-yl)acetic acid::US10273259, Example 818::US10711020, Example 818 Nuclear receptor ROR-gamma Mus musculus 848 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383107&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669154 404852411 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765718 CC(CO)(CO)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO5S/c1-22(13-36,14-37)21(38)35-11-10-23(41(39,40)18-6-4-17(27)5-7-18)19-8-3-16(12-15(19)2-9-20(23)35)24(28,25(29,30)31)26(32,33)34/h3-8,12,20,36-37H,2,9-11,13-14H2,1H3/t20-,23-/m1/s1 SJISJDDTPYIHDW-NFBKMPQASA-N 383108 1-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)-3-hydroxy-2-(hydroxymethyl)-2-methylpropan-1-one::US10273259, Example 819::US10711020, Example 819 Nuclear receptor ROR-gamma Mus musculus 29.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383108&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669151 404852412 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765719 CC1(COP(O)(=O)OC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H24F8NO7PS/c1-22(13-41-43(37,38)42-14-22)21(36)35-11-10-23(44(39,40)18-6-4-17(27)5-7-18)19-8-3-16(12-15(19)2-9-20(23)35)24(28,25(29,30)31)26(32,33)34/h3-8,12,20H,2,9-11,13-14H2,1H3,(H,37,38)/t20-,23-/m1/s1 XRBKBRHJDSCDDG-NFBKMPQASA-N 383109 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(2-hydroxy-5-methyl-2-oxido-1,3,2-dioxaphosphinan-5-yl)methanone::US10273259, Example 820::US10711020, Example 820 Nuclear receptor ROR-gamma Mus musculus 47.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383109&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669278 404852413 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765720 CC1(COP(N)(=O)OC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8N2O6PS/c1-22(13-41-43(35,38)42-14-22)21(37)36-11-10-23(44(39,40)18-6-4-17(27)5-7-18)19-8-3-16(12-15(19)2-9-20(23)36)24(28,25(29,30)31)26(32,33)34/h3-8,12,20H,2,9-11,13-14H2,1H3,(H2,35,38)/t20-,22?,23-,43?/m1/s1 FQJBALRISFYQFS-YPCLUYDESA-N 383110 (2-amino-5-methyl-2-oxido-1,3,2-dioxaphosphinan-5-yl)((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methanone::US10273259, Example 821::US10711020, Example 821 Nuclear receptor ROR-gamma Mus musculus 18.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383110&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669061 404852414 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765721 CC1(COP(C)(=O)OC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8NO6PS/c1-23(14-41-43(2,38)42-15-23)22(37)36-12-11-24(44(39,40)19-7-5-18(28)6-8-19)20-9-4-17(13-16(20)3-10-21(24)36)25(29,26(30,31)32)27(33,34)35/h4-9,13,21H,3,10-12,14-15H2,1-2H3/t21-,23?,24-,43?/m1/s1 ZJYVFLYPUYHVNV-WJSCHIDKSA-N 383111 (2,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-5-yl)((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methanone (Two Homochiral Isomers)::US10273259, Example 822::US10273259, Example 823::US10711020, Example 823 Nuclear receptor ROR-gamma Mus musculus 49.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383111&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669172 404852415 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765722 CC1(COP(C)(=O)OC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H26F8NO6PS/c1-23(14-41-43(2,38)42-15-23)22(37)36-12-11-24(44(39,40)19-7-5-18(28)6-8-19)20-9-4-17(13-16(20)3-10-21(24)36)25(29,26(30,31)32)27(33,34)35/h4-9,13,21H,3,10-12,14-15H2,1-2H3/t21-,23?,24-,43?/m1/s1 ZJYVFLYPUYHVNV-WJSCHIDKSA-N 383111 (2,5-dimethyl-2-oxido-1,3,2-dioxaphosphinan-5-yl)((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methanone (Two Homochiral Isomers)::US10273259, Example 822::US10273259, Example 823::US10711020, Example 823 Nuclear receptor ROR-gamma Mus musculus 39.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383111&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669172 404852415 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765723 OC(=O)c1ccc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H20F9NO5S/c30-18-4-6-19(7-5-18)45(43,44)26-11-12-39(24(40)16-1-8-20(25(41)42)22(31)14-16)23(26)10-2-15-13-17(3-9-21(15)26)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,23H,2,10-12H2,(H,41,42)/t23-,26-/m1/s1 XIACOCZEICGICV-ZEQKJWHPSA-N 383113 2-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)benzamide and 2-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)benzoic acid::US10273259, Example 824::US10273259, Example 825::US10711020, Example 825 Nuclear receptor ROR-gamma Mus musculus 142 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383113&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669083 404852416 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765724 OC(=O)c1ccc(cc1F)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H20F9NO5S/c30-18-4-6-19(7-5-18)45(43,44)26-11-12-39(24(40)16-1-8-20(25(41)42)22(31)14-16)23(26)10-2-15-13-17(3-9-21(15)26)27(32,28(33,34)35)29(36,37)38/h1,3-9,13-14,23H,2,10-12H2,(H,41,42)/t23-,26-/m1/s1 XIACOCZEICGICV-ZEQKJWHPSA-N 383113 2-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)benzamide and 2-fluoro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)benzoic acid::US10273259, Example 824::US10273259, Example 825::US10711020, Example 825 Nuclear receptor ROR-gamma Mus musculus 489 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383113&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669083 404852416 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765725 OC(C(O)=O)c1ccc(cc1Cl)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H22ClF8NO6S/c31-22-14-16(1-8-20(22)24(41)26(43)44)25(42)40-12-11-27(47(45,46)19-6-4-18(32)5-7-19)21-9-3-17(13-15(21)2-10-23(27)40)28(33,29(34,35)36)30(37,38)39/h1,3-9,13-14,23-24,41H,2,10-12H2,(H,43,44)/t23-,24?,27-/m1/s1 ZKYJEQPHVBKIEX-GJQXLMDHSA-N 383115 (RS)-2-(2-chloro-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-v)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)phenyl)-2-hydroxyacetic acid::US10273259, Example 826::US10711020, Example 826 Nuclear receptor ROR-gamma Mus musculus 1086 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383115&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669093 404852417 C02929 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765726 OC(C(O)=O)c1ccc(cc1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H23F8NO6S/c31-20-7-9-21(10-8-20)46(44,45)27-13-14-39(25(41)17-3-1-16(2-4-17)24(40)26(42)43)23(27)12-5-18-15-19(6-11-22(18)27)28(32,29(33,34)35)30(36,37)38/h1-4,6-11,15,23-24,40H,5,12-14H2,(H,42,43)/t23-,24?,27-/m1/s1 SGMCRRZFRGAWRB-GJQXLMDHSA-N 383116 (RS)-2-(4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)phenyl)-2-hydroxyacetic acid::US10273259, Example 827::US10711020, Example 827 Nuclear receptor ROR-gamma Mus musculus 78.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383116&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669263 404852418 C02929 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765727 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(F)CCS(=O)(=O)CC1 InChI=1S/C27H24F9NO5S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-37(22(38)23(29)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(30,26(31,32)33)27(34,35)36/h2-7,15,21H,1,8-14H2/t21-,24-/m1/s1 LLGWTSRFQCMJHP-ZJSXRUAMSA-N 383117 (4-fluoro-1,1-dioxidotetrahydro-2H-thiopyran-4-yl)((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)methanone::US10273259, Example 828::US10711020, Example 828 Nuclear receptor ROR-gamma Mus musculus 8.00 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383117&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669282 404852419 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765728 Fc1ccc(cc1)S(=O)(=O)[C@@]12CCN([C@@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)C(=O)C1(F)CCOCC1 InChI=1S/C27H24F9NO4S/c28-18-3-5-19(6-4-18)42(39,40)24-9-12-37(22(38)23(29)10-13-41-14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(30,26(31,32)33)27(34,35)36/h2-7,15,21H,1,8-14H2/t21-,24-/m1/s1 GBIHFDAXNUDWEE-ZJSXRUAMSA-N 383118 ((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)(4-fluorotetrahydro-2H-pyran-4-yl)methanone::US10273259, Example 829::US10711020, Example 829 Nuclear receptor ROR-gamma Mus musculus 47.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383118&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669095 404852420 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765729 C[C@H]1CC(CC[C@H]1C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1)C(C)=O InChI=1S/C31H31F8NO4S/c1-17-14-19(18(2)41)6-9-24(17)27(42)40-13-12-28(45(43,44)23-5-3-4-22(32)16-23)25-10-8-21(15-20(25)7-11-26(28)40)29(33,30(34,35)36)31(37,38)39/h3-5,8,10,15-17,19,24,26H,6-7,9,11-14H2,1-2H3/t17-,19?,24+,26?,28?/m0/s1 PWICJAKUDLLQCE-LGXRGQGLSA-N 383119 (3S,4R)-4-(9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid::US10273259, Example 830 Nuclear receptor ROR-gamma Mus musculus 32.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383119&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 138592547 404852421 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765730 C[C@H]1CC(CC[C@H]1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-18(26(41)42)2-9-22(16)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22+,24+,27+/m0/s1 JQORWGARJVSRBA-UFHIEMDVSA-N 383120 (3S,4R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid::US10273259, Example 831::US10711020, Example 831 Nuclear receptor ROR-gamma Mus musculus 93.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383120&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669119 404852422 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765731 C[C@@H]1CC(CC[C@H]1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-18(26(41)42)2-9-22(16)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22-,24-,27-/m1/s1 JQORWGARJVSRBA-FXRNFHIUSA-N 383121 (3R,4R)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-3-methylcyclohexane-1-carboxylic acid::US10273259, Example 832::US10711020, Example 832 Nuclear receptor ROR-gamma Mus musculus 209 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383121&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669236 404852423 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765732 C[C@H]1CC(O)CC[C@H]1C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C29H29F8NO4S/c1-16-13-20(39)7-8-22(16)25(40)38-12-11-26(43(41,42)21-4-2-3-19(30)15-21)23-9-6-18(14-17(23)5-10-24(26)38)27(31,28(32,33)34)29(35,36)37/h2-4,6,9,14-16,20,22,24,39H,5,7-8,10-13H2,1H3/t16-,20?,22+,24?,26?/m0/s1 FFZHKKVFUNSGEG-QXUMJZPISA-N 383122 (9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)((1R,2S)-4-hydroxy-2-methylcyclohexyl)methanone::US10273259, Example 833::US10711020, Example 833 Nuclear receptor ROR-gamma Mus musculus 74.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383122&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669087 404852424 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765733 C[C@H]1CC(C)(O)CC[C@H]1C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H31F8NO4S/c1-17-16-26(2,41)11-10-22(17)25(40)39-13-12-27(44(42,43)21-5-3-4-20(31)15-21)23-8-7-19(14-18(23)6-9-24(27)39)28(32,29(33,34)35)30(36,37)38/h3-5,7-8,14-15,17,22,24,41H,6,9-13,16H2,1-2H3/t17-,22+,24?,26?,27?/m0/s1 JOORRAWMWPLQPV-VVAIGMAFSA-N 383123 (9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)((1R,2S)-4-hydroxy-2,4-dimethylcyclohexyl)methanone (2 Single Diastereomers)::US10273259, Example 834::US10273259, Example 835::US10711020, Example 835 Nuclear receptor ROR-gamma Mus musculus 172 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383123&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669089 404852425 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765734 C[C@H]1CC(C)(O)CC[C@H]1C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H31F8NO4S/c1-17-16-26(2,41)11-10-22(17)25(40)39-13-12-27(44(42,43)21-5-3-4-20(31)15-21)23-8-7-19(14-18(23)6-9-24(27)39)28(32,29(33,34)35)30(36,37)38/h3-5,7-8,14-15,17,22,24,41H,6,9-13,16H2,1-2H3/t17-,22+,24?,26?,27?/m0/s1 JOORRAWMWPLQPV-VVAIGMAFSA-N 383123 (9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indol-3-yl)((1R,2S)-4-hydroxy-2,4-dimethylcyclohexyl)methanone (2 Single Diastereomers)::US10273259, Example 834::US10273259, Example 835::US10711020, Example 835 Nuclear receptor ROR-gamma Mus musculus 83.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383123&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669089 404852425 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765735 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H29F8NO5S/c1-16-13-18(5-8-22(16)26(41)42)25(40)39-12-11-27(45(43,44)21-4-2-3-20(31)15-21)23-9-7-19(14-17(23)6-10-24(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,7,9,14-16,18,22,24H,5-6,8,10-13H2,1H3,(H,41,42)/t16-,18?,22+,24?,27?/m0/s1 VSNITFSVOGKQJM-PEZFPZIYSA-N 383125 (1R,2S)-4-(9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 836::US10273259, Example 837::US10711020, Example 837 Nuclear receptor ROR-gamma Mus musculus 13.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383125&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669165 404852426 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765736 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1cccc(F)c1 InChI=1S/C30H29F8NO5S/c1-16-13-18(5-8-22(16)26(41)42)25(40)39-12-11-27(45(43,44)21-4-2-3-20(31)15-21)23-9-7-19(14-17(23)6-10-24(27)39)28(32,29(33,34)35)30(36,37)38/h2-4,7,9,14-16,18,22,24H,5-6,8,10-13H2,1H3,(H,41,42)/t16-,18?,22+,24?,27?/m0/s1 VSNITFSVOGKQJM-PEZFPZIYSA-N 383125 (1R,2S)-4-(9b-((3-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 836::US10273259, Example 837::US10711020, Example 837 Nuclear receptor ROR-gamma Mus musculus 56.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383125&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669165 404852426 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765737 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-14-18(2-9-22(16)26(41)42)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22+,24+,27+/m0/s1 RVOCLWFWWBLIOH-UFHIEMDVSA-N 383127 (1R,2S)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 838::US10273259, Example 839::US10273259, Example 840::US10273259, Example 841::US10711020, Example 839 Nuclear receptor ROR-gamma Mus musculus 75.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383127&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669203 404852427 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765738 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-14-18(2-9-22(16)26(41)42)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22+,24+,27+/m0/s1 RVOCLWFWWBLIOH-UFHIEMDVSA-N 383127 (1R,2S)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 838::US10273259, Example 839::US10273259, Example 840::US10273259, Example 841::US10711020, Example 839 Nuclear receptor ROR-gamma Mus musculus 416 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383127&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669203 404852427 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765739 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-14-18(2-9-22(16)26(41)42)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22+,24+,27+/m0/s1 RVOCLWFWWBLIOH-UFHIEMDVSA-N 383127 (1R,2S)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 838::US10273259, Example 839::US10273259, Example 840::US10273259, Example 841::US10711020, Example 839 Nuclear receptor ROR-gamma Mus musculus 82.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383127&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669203 404852427 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765740 C[C@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F8NO5S/c1-16-14-18(2-9-22(16)26(41)42)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18?,22+,24+,27+/m0/s1 RVOCLWFWWBLIOH-UFHIEMDVSA-N 383127 (1R,2S)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 838::US10273259, Example 839::US10273259, Example 840::US10273259, Example 841::US10711020, Example 839 Nuclear receptor ROR-gamma Mus musculus 215 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383127&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669203 404852427 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765741 C[C@@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c1-15-12-16(2-8-20(15)25(40)41)24(39)38-11-10-26(45(42,43)19-6-4-18(30)5-7-19)21-9-3-17(13-22(21)44-14-23(26)38)27(31,28(32,33)34)29(35,36)37/h3-7,9,13,15-16,20,23H,2,8,10-12,14H2,1H3,(H,40,41)/t15-,16?,20-,23?,26?/m1/s1 SVXGUOLWCJKEHB-SLSVQMFKSA-N 383131 (1R,2R)-4-(9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3,3a,4,9b-hexahydrochromeno[3,4-b]pyrrole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 842::US10273259, Example 843::US10711020, Example 843 Nuclear receptor ROR-gamma Mus musculus 53.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383131&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669272 404852428 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765742 C[C@@H]1CC(CC[C@H]1C(O)=O)C(=O)N1CCC2(C1COc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H27F8NO6S/c1-15-12-16(2-8-20(15)25(40)41)24(39)38-11-10-26(45(42,43)19-6-4-18(30)5-7-19)21-9-3-17(13-22(21)44-14-23(26)38)27(31,28(32,33)34)29(35,36)37/h3-7,9,13,15-16,20,23H,2,8,10-12,14H2,1H3,(H,40,41)/t15-,16?,20-,23?,26?/m1/s1 SVXGUOLWCJKEHB-SLSVQMFKSA-N 383131 (1R,2R)-4-(9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-1,2,3,3a,4,9b-hexahydrochromeno[3,4-b]pyrrole-3-carbonyl)-2-methylcyclohexane-1-carboxylic acid (2 Single Diastereomers)::US10273259, Example 842::US10273259, Example 843::US10711020, Example 843 Nuclear receptor ROR-gamma Mus musculus 92.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383131&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669272 404852428 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765743 OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(c(Cl)cc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H26ClF8NO5S/c30-22-14-20-17(13-21(22)27(32,28(33,34)35)29(36,37)38)5-10-23-26(20,45(43,44)19-8-6-18(31)7-9-19)11-12-39(23)24(40)15-1-3-16(4-2-15)25(41)42/h6-9,13-16,23H,1-5,10-12H2,(H,41,42)/t15-,16-,23-,26-/m1/s1 NRSGHJVWWWPCST-DBJAZQRGSA-N 383133 (1R,4r)-4-((3aR,9bR)-8-chloro-9b-((4-fluorophenyl)sulfonyl)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 844::US10711020, Example 844 Nuclear receptor ROR-gamma Mus musculus 97.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383133&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669221 404852429 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765744 Cc1cc2c(CC[C@H]3N(CC[C@@]23S(=O)(=O)c2ccc(F)cc2)C(=O)[C@H]2CC[C@@H](CC2)C(O)=O)cc1C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C30H29F8NO5S/c1-16-14-23-19(15-22(16)28(32,29(33,34)35)30(36,37)38)6-11-24-27(23,45(43,44)21-9-7-20(31)8-10-21)12-13-39(24)25(40)17-2-4-18(5-3-17)26(41)42/h7-10,14-15,17-18,24H,2-6,11-13H2,1H3,(H,41,42)/t17-,18-,24-,27-/m1/s1 ZFVKCNIIMDQMAG-BKNJMBQISA-N 383134 (1R,4r)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-8-methyl-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 845::US10711020, Example 845 Nuclear receptor ROR-gamma Mus musculus 205 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383134&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669054 404852430 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765745 Cc1cc2c(CC[C@H]3N(CC[C@@]23S(=O)(=O)c2ccc(F)cc2)C(=O)[C@H]2CC[C@@H](CC2)C(O)=O)c(C)c1C(F)(C(F)(F)F)C(F)(F)F InChI=1S/C31H31F8NO5S/c1-16-15-23-22(17(2)25(16)29(33,30(34,35)36)31(37,38)39)11-12-24-28(23,46(44,45)21-9-7-20(32)8-10-21)13-14-40(24)26(41)18-3-5-19(6-4-18)27(42)43/h7-10,15,18-19,24H,3-6,11-14H2,1-2H3,(H,42,43)/t18-,19-,24-,28-/m1/s1 HCMHBZWUIVDPJD-XARWWFPVSA-N 383135 (1R,4r)-4-((3aR,9bR)-9b-((4-fluorophenyl)sulfonyl)-6,8-dimethyl(d6)-7-(perfluoropropan-2-yl)-2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole-3-carbonyl)cyclohexane-1-carboxylic acid::US10273259, Example 846::US10711020, Example 846 Nuclear receptor ROR-gamma Mus musculus 57.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383135&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145995617 404852431 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765746 COC(=O)C1(CCS(=O)(=O)CC1)NC(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C29H28F8N2O7S2/c1-46-23(40)25(11-14-47(42,43)15-12-25)38-24(41)39-13-10-26(48(44,45)20-6-4-19(30)5-7-20)21-8-3-18(16-17(21)2-9-22(26)39)27(31,28(32,33)34)29(35,36)37/h3-8,16,22H,2,9-15H2,1H3,(H,38,41)/t22-,26-/m1/s1 ZVHOSUKFUWRCTF-ATIYNZHBSA-N 383136 US10273259, Example 847::US10711020, Example 847 Nuclear receptor ROR-gamma Mus musculus 99.0 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383136&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122678953 404852432 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 765747 FC(F)(F)C(F)(c1ccc2c(CC[C@@H]3N(CC[C@]23S(=O)(=O)c2ccccc2)C(=O)CN2CCS(=O)(=O)CC2)c1)C(F)(F)F InChI=1S/C27H27F7N2O5S2/c28-25(26(29,30)31,27(32,33)34)19-7-8-21-18(16-19)6-9-22-24(21,43(40,41)20-4-2-1-3-5-20)10-11-36(22)23(37)17-35-12-14-42(38,39)15-13-35/h1-5,7-8,16,22H,6,9-15,17H2/t22-,24-/m0/s1 DOMKFIOVSXNRFY-UPVQGACJSA-N 383137 US10273259, Example 848::US10711020, Example 848 Nuclear receptor ROR-gamma Mus musculus 3306 US Patent 10.7270/Q2MW2KG7 aid1798534 US10273259 Duan, J; Dhar, TG; Marcoux, D; Cherney, RJ Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=383137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=383137&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122679208 404852433 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51014073 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(Cl)c2)-c2ccccc2C(F)(F)F)cc1 InChI=1S/C23H19ClF3NO3S/c1-2-32(30,31)17-10-7-15(8-11-17)13-22(29)28-16-9-12-19(21(24)14-16)18-5-3-4-6-20(18)23(25,26)27/h3-12,14H,2,13H2,1H3,(H,28,29) WYXIDCLTNIMPSC-UHFFFAOYSA-N 50112600 CHEMBL3609392 Nuclear receptor ROR-gamma Mus musculus 200 ChEMBL 10.1021/acsmedchemlett.7b00476 10.7270/Q2Q81GM4 29456799 Wang, Y; Cai, W; Tang, T; Liu, Q; Yang, T; Yang, L; Ma, Y; Zhang, G; Huang, Y; Song, X; Orband-Miller, LA; Wu, Q; Zhou, L; Xiang, Z; Xiang, JN; Leung, S; Shao, L; Lin, X; Lobera, M; Ren, F Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112600&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 71283813 319493587 CHEMBL3609392 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51014074 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(Cl)c2)-c2ccc(CC3CCN(CC3)C(=O)C(C)(C)C)cc2C(F)(F)F)cc1 InChI=1S/C34H38ClF3N2O4S/c1-5-45(43,44)26-10-6-22(7-11-26)20-31(41)39-25-9-13-28(30(35)21-25)27-12-8-24(19-29(27)34(36,37)38)18-23-14-16-40(17-15-23)32(42)33(2,3)4/h6-13,19,21,23H,5,14-18,20H2,1-4H3,(H,39,41) DSUHTCDYHNKKDP-UHFFFAOYSA-N 50287483 CHEMBL4173830 Nuclear receptor ROR-gamma Mus musculus 25 ChEMBL 10.1021/acsmedchemlett.7b00476 10.7270/Q2Q81GM4 29456799 Wang, Y; Cai, W; Tang, T; Liu, Q; Yang, T; Yang, L; Ma, Y; Zhang, G; Huang, Y; Song, X; Orband-Miller, LA; Wu, Q; Zhou, L; Xiang, Z; Xiang, JN; Leung, S; Shao, L; Lin, X; Lobera, M; Ren, F Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50287483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50287483&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 44292529 104129054 58001 ZINC29226409 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137254 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2cccnc2)cc1 InChI=1S/C25H27N3O4S/c1-4-33(31,32)22-13-7-18(8-14-22)16-23(29)27-20-11-9-19(10-12-20)25(2,3)24(30)28-21-6-5-15-26-17-21/h5-15,17H,4,16H2,1-3H3,(H,27,29)(H,28,30) KQAOXJFUGXGGPH-UHFFFAOYSA-N 50466364 CHEMBL4287670 Nuclear receptor ROR-gamma Mus musculus 4500 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466364&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145990929 433933629 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137256 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccccc2F)cc1 InChI=1S/C26H27FN2O4S/c1-4-34(32,33)21-15-9-18(10-16-21)17-24(30)28-20-13-11-19(12-14-20)26(2,3)25(31)29-23-8-6-5-7-22(23)27/h5-16H,4,17H2,1-3H3,(H,28,30)(H,29,31) MEJYFHSTMVGYPM-UHFFFAOYSA-N 50466366 CHEMBL4286190 Nuclear receptor ROR-gamma Mus musculus 100 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466366&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145990013 433933631 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137259 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)N2CCc3ccccc23)cc1 InChI=1S/C28H30N2O4S/c1-4-35(33,34)24-15-9-20(10-16-24)19-26(31)29-23-13-11-22(12-14-23)28(2,3)27(32)30-18-17-21-7-5-6-8-25(21)30/h5-16H,4,17-19H2,1-3H3,(H,29,31) GXNJWSJMKRTTPH-UHFFFAOYSA-N 50466369 CHEMBL4282801 Nuclear receptor ROR-gamma Mus musculus 110 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466369&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145981346 433933634 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137264 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)N(C)C)cc1 InChI=1S/C22H28N2O4S/c1-6-29(27,28)19-13-7-16(8-14-19)15-20(25)23-18-11-9-17(10-12-18)22(2,3)21(26)24(4)5/h7-14H,6,15H2,1-5H3,(H,23,25) XDNHZEZVJTXHGD-UHFFFAOYSA-N 50466365 CHEMBL4277538 Nuclear receptor ROR-gamma Mus musculus >10000 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466365&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145985845 433933630 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137265 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccccc2C)cc1 InChI=1S/C27H30N2O4S/c1-5-34(32,33)23-16-10-20(11-17-23)18-25(30)28-22-14-12-21(13-15-22)27(3,4)26(31)29-24-9-7-6-8-19(24)2/h6-17H,5,18H2,1-4H3,(H,28,30)(H,29,31) JGGUTUIYDPVIQU-UHFFFAOYSA-N 50466372 CHEMBL4285176 Nuclear receptor ROR-gamma Mus musculus 6800 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466372&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145993272 433933637 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137271 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)N2Cc3ccccc3C2)cc1 InChI=1S/C28H30N2O4S/c1-4-35(33,34)25-15-9-20(10-16-25)17-26(31)29-24-13-11-23(12-14-24)28(2,3)27(32)30-18-21-7-5-6-8-22(21)19-30/h5-16H,4,17-19H2,1-3H3,(H,29,31) HXLFKSOYXHHJCW-UHFFFAOYSA-N 50466373 CHEMBL4278285 Nuclear receptor ROR-gamma Mus musculus 1900 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466373&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145980027 433933638 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137273 CCOC(=O)C(C)(C)c1ccc(NC(=O)Cc2ccc(cc2)S(=O)(=O)CC)cc1 InChI=1S/C22H27NO5S/c1-5-28-21(25)22(3,4)17-9-11-18(12-10-17)23-20(24)15-16-7-13-19(14-8-16)29(26,27)6-2/h7-14H,5-6,15H2,1-4H3,(H,23,24) FHABWAHHBSKNOS-UHFFFAOYSA-N 50466370 CHEMBL4285485 Nuclear receptor ROR-gamma Mus musculus 3100 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466370&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145992194 433933635 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137274 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)N2CCC2)cc1 InChI=1S/C23H28N2O4S/c1-4-30(28,29)20-12-6-17(7-13-20)16-21(26)24-19-10-8-18(9-11-19)23(2,3)22(27)25-14-5-15-25/h6-13H,4-5,14-16H2,1-3H3,(H,24,26) ZIIYCIXZMYHIDE-UHFFFAOYSA-N 50466378 CHEMBL4282063 Nuclear receptor ROR-gamma Mus musculus >10000 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466378&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145981784 433933643 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137275 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)N2CC3(CCC3)C2)cc1 InChI=1S/C26H32N2O4S/c1-4-33(31,32)22-12-6-19(7-13-22)16-23(29)27-21-10-8-20(9-11-21)25(2,3)24(30)28-17-26(18-28)14-5-15-26/h6-13H,4-5,14-18H2,1-3H3,(H,27,29) SLDVOINBPKMOPL-UHFFFAOYSA-N 50466379 CHEMBL4292660 Nuclear receptor ROR-gamma Mus musculus 10000 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466379&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145987881 433933644 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137276 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)N2CCCCC2)cc1 InChI=1S/C25H32N2O4S/c1-4-32(30,31)22-14-8-19(9-15-22)18-23(28)26-21-12-10-20(11-13-21)25(2,3)24(29)27-16-6-5-7-17-27/h8-15H,4-7,16-18H2,1-3H3,(H,26,28) DWMTUTVNKOTWEW-UHFFFAOYSA-N 50466380 CHEMBL4287342 Nuclear receptor ROR-gamma Mus musculus >10000 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466380&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145991576 433933645 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137277 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccccc2)cc1 InChI=1S/C26H28N2O4S/c1-4-33(31,32)23-16-10-19(11-17-23)18-24(29)27-22-14-12-20(13-15-22)26(2,3)25(30)28-21-8-6-5-7-9-21/h5-17H,4,18H2,1-3H3,(H,27,29)(H,28,30) QECSHZAJHGHAOA-UHFFFAOYSA-N 50466374 CHEMBL4279420 Nuclear receptor ROR-gamma Mus musculus 470 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466374&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 9A0 5ZA1 134821990 433933639 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137278 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccccc2F)cc1 InChI=1S/C26H27FN2O4S/c1-4-34(32,33)21-15-9-18(10-16-21)17-24(30)28-20-13-11-19(12-14-20)26(2,3)25(31)29-23-8-6-5-7-22(23)27/h5-16H,4,17H2,1-3H3,(H,28,30)(H,29,31) MEJYFHSTMVGYPM-UHFFFAOYSA-N 50466366 CHEMBL4286190 Nuclear receptor ROR-gamma Mus musculus 100 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466366&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145990013 433933631 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137279 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2cccc(F)c2)cc1 InChI=1S/C26H27FN2O4S/c1-4-34(32,33)23-14-8-18(9-15-23)16-24(30)28-21-12-10-19(11-13-21)26(2,3)25(31)29-22-7-5-6-20(27)17-22/h5-15,17H,4,16H2,1-3H3,(H,28,30)(H,29,31) IKKTYHVOFCDTIW-UHFFFAOYSA-N 50466381 CHEMBL4281750 Nuclear receptor ROR-gamma Mus musculus 260 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466381&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145979726 433933646 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137280 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccc(F)cc2)cc1 InChI=1S/C26H27FN2O4S/c1-4-34(32,33)23-15-5-18(6-16-23)17-24(30)28-21-11-7-19(8-12-21)26(2,3)25(31)29-22-13-9-20(27)10-14-22/h5-16H,4,17H2,1-3H3,(H,28,30)(H,29,31) KUBGKOCHEJNDBQ-UHFFFAOYSA-N 50466382 CHEMBL4289622 Nuclear receptor ROR-gamma Mus musculus 550 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466382&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145232219 433933647 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137281 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccc(F)cc2F)cc1 InChI=1S/C26H26F2N2O4S/c1-4-35(33,34)21-12-5-17(6-13-21)15-24(31)29-20-10-7-18(8-11-20)26(2,3)25(32)30-23-14-9-19(27)16-22(23)28/h5-14,16H,4,15H2,1-3H3,(H,29,31)(H,30,32) RRCSJXJNTIZFGN-UHFFFAOYSA-N 50466383 CHEMBL4293008 Nuclear receptor ROR-gamma Mus musculus 1800 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466383&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145988768 433933648 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137287 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccncc2)cc1 InChI=1S/C25H27N3O4S/c1-4-33(31,32)22-11-5-18(6-12-22)17-23(29)27-20-9-7-19(8-10-20)25(2,3)24(30)28-21-13-15-26-16-14-21/h5-16H,4,17H2,1-3H3,(H,27,29)(H,26,28,30) HYODHXOVVYJCLQ-UHFFFAOYSA-N 50466371 CHEMBL4282807 Nuclear receptor ROR-gamma Mus musculus >10000 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466371 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466371&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145981807 433933636 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137288 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2ccc(F)cc2F)cc1 InChI=1S/C26H25F3N2O4S/c1-4-36(34,35)19-9-5-16(6-10-19)13-24(32)30-18-8-11-20(21(28)15-18)26(2,3)25(33)31-23-12-7-17(27)14-22(23)29/h5-12,14-15H,4,13H2,1-3H3,(H,30,32)(H,31,33) DZUAIKQCQQBQJM-UHFFFAOYSA-N 50466375 CHEMBL4287674 Nuclear receptor ROR-gamma Mus musculus 200 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466375&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137796283 433933640 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137289 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2ccc(F)cc2)cc1 InChI=1S/C26H26F2N2O4S/c1-4-35(33,34)21-12-5-17(6-13-21)15-24(31)29-20-11-14-22(23(28)16-20)26(2,3)25(32)30-19-9-7-18(27)8-10-19/h5-14,16H,4,15H2,1-3H3,(H,29,31)(H,30,32) JCIWZUTVGHDCLP-UHFFFAOYSA-N 50466367 CHEMBL4290041 Nuclear receptor ROR-gamma Mus musculus 420 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466367&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145987785 433933632 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137297 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ncccc2F)cc1 InChI=1S/C25H26FN3O4S/c1-4-34(32,33)20-13-7-17(8-14-20)16-22(30)28-19-11-9-18(10-12-19)25(2,3)24(31)29-23-21(26)6-5-15-27-23/h5-15H,4,16H2,1-3H3,(H,28,30)(H,27,29,31) JIHVDVKUIJBBOQ-UHFFFAOYSA-N 50466389 CHEMBL4286196 Nuclear receptor ROR-gamma Mus musculus >10000 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466389&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145990222 433933654 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137298 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2cccc(n2)C(F)(F)F)cc1 InChI=1S/C26H26F3N3O4S/c1-4-37(35,36)20-14-8-17(9-15-20)16-23(33)30-19-12-10-18(11-13-19)25(2,3)24(34)32-22-7-5-6-21(31-22)26(27,28)29/h5-15H,4,16H2,1-3H3,(H,30,33)(H,31,32,34) GCFVZQBDTLIGHP-UHFFFAOYSA-N 50466385 CHEMBL4294504 Nuclear receptor ROR-gamma Mus musculus 5400 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466385&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145994167 433933650 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137299 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2cc(Cl)ccn2)cc1 InChI=1S/C25H26ClN3O4S/c1-4-34(32,33)21-11-5-17(6-12-21)15-23(30)28-20-9-7-18(8-10-20)25(2,3)24(31)29-22-16-19(26)13-14-27-22/h5-14,16H,4,15H2,1-3H3,(H,28,30)(H,27,29,31) RRFLKMHAGGWGSE-UHFFFAOYSA-N 50466386 CHEMBL4286603 Nuclear receptor ROR-gamma Mus musculus 100 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466386 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466386&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145992026 433933651 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137300 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2cc(ccn2)C#N)cc1 InChI=1S/C26H26N4O4S/c1-4-35(33,34)22-11-5-18(6-12-22)16-24(31)29-21-9-7-20(8-10-21)26(2,3)25(32)30-23-15-19(17-27)13-14-28-23/h5-15H,4,16H2,1-3H3,(H,29,31)(H,28,30,32) OACVLQCPGWVPLX-UHFFFAOYSA-N 50466387 CHEMBL4279356 Nuclear receptor ROR-gamma Mus musculus 290 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466387&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145981666 433933652 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137301 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2ccc(F)cc2)cc1 InChI=1S/C26H26F2N2O4S/c1-4-35(33,34)21-12-5-17(6-13-21)15-24(31)29-20-11-14-22(23(28)16-20)26(2,3)25(32)30-19-9-7-18(27)8-10-19/h5-14,16H,4,15H2,1-3H3,(H,29,31)(H,30,32) JCIWZUTVGHDCLP-UHFFFAOYSA-N 50466367 CHEMBL4290041 Nuclear receptor ROR-gamma Mus musculus 250 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466367&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145987785 433933632 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137302 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2cc(ccn2)C#N)cc1 InChI=1S/C26H25FN4O4S/c1-4-36(34,35)20-8-5-17(6-9-20)14-24(32)30-19-7-10-21(22(27)15-19)26(2,3)25(33)31-23-13-18(16-28)11-12-29-23/h5-13,15H,4,14H2,1-3H3,(H,30,32)(H,29,31,33) DUHFUKXNEHGMID-UHFFFAOYSA-N 50466377 CHEMBL4279772 Nuclear receptor ROR-gamma Mus musculus 74 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466377&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145980094 433933642 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137310 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2cccc(F)c2)cc1 InChI=1S/C26H27FN2O4S/c1-4-34(32,33)23-14-8-18(9-15-23)16-24(30)28-21-12-10-19(11-13-21)26(2,3)25(31)29-22-7-5-6-20(27)17-22/h5-15,17H,4,16H2,1-3H3,(H,28,30)(H,29,31) IKKTYHVOFCDTIW-UHFFFAOYSA-N 50466381 CHEMBL4281750 Nuclear receptor ROR-gamma Mus musculus 290 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466381&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145979726 433933646 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137311 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccc(F)cc2)cc1 InChI=1S/C26H27FN2O4S/c1-4-34(32,33)23-15-5-18(6-16-23)17-24(30)28-21-11-7-19(8-12-21)26(2,3)25(31)29-22-13-9-20(27)10-14-22/h5-16H,4,17H2,1-3H3,(H,28,30)(H,29,31) KUBGKOCHEJNDBQ-UHFFFAOYSA-N 50466382 CHEMBL4289622 Nuclear receptor ROR-gamma Mus musculus 1100 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466382&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145232219 433933647 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137312 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccc(F)cc2F)cc1 InChI=1S/C26H26F2N2O4S/c1-4-35(33,34)21-12-5-17(6-13-21)15-24(31)29-20-10-7-18(8-11-20)26(2,3)25(32)30-23-14-9-19(27)16-22(23)28/h5-14,16H,4,15H2,1-3H3,(H,29,31)(H,30,32) RRCSJXJNTIZFGN-UHFFFAOYSA-N 50466383 CHEMBL4293008 Nuclear receptor ROR-gamma Mus musculus 1300 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466383&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145988768 433933648 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137323 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccccc2)cc1 InChI=1S/C26H28N2O4S/c1-4-33(31,32)23-16-10-19(11-17-23)18-24(29)27-22-14-12-20(13-15-22)26(2,3)25(30)28-21-8-6-5-7-9-21/h5-17H,4,18H2,1-3H3,(H,27,29)(H,28,30) QECSHZAJHGHAOA-UHFFFAOYSA-N 50466374 CHEMBL4279420 Nuclear receptor ROR-gamma Mus musculus 480 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466374&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 9A0 5ZA1 134821990 433933639 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137324 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2ccccn2)cc1 InChI=1S/C25H27N3O4S/c1-4-33(31,32)21-14-8-18(9-15-21)17-23(29)27-20-12-10-19(11-13-20)25(2,3)24(30)28-22-7-5-6-16-26-22/h5-16H,4,17H2,1-3H3,(H,27,29)(H,26,28,30) DTPQMAMBOUCQQW-UHFFFAOYSA-N 50466388 CHEMBL4279768 Nuclear receptor ROR-gamma Mus musculus 1300 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466388&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145979878 433933653 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137327 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2cc(ccn2)C(F)(F)F)cc1 InChI=1S/C26H26F3N3O4S/c1-4-37(35,36)21-11-5-17(6-12-21)15-23(33)31-20-9-7-18(8-10-20)25(2,3)24(34)32-22-16-19(13-14-30-22)26(27,28)29/h5-14,16H,4,15H2,1-3H3,(H,31,33)(H,30,32,34) JYILEEZLFMGOKQ-UHFFFAOYSA-N 50466368 CHEMBL4278291 Nuclear receptor ROR-gamma Mus musculus 78 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466368&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145980263 433933633 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137328 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2ccc(F)cc2F)cc1 InChI=1S/C26H25F3N2O4S/c1-4-36(34,35)19-9-5-16(6-10-19)13-24(32)30-18-8-11-20(21(28)15-18)26(2,3)25(33)31-23-12-7-17(27)14-22(23)29/h5-12,14-15H,4,13H2,1-3H3,(H,30,32)(H,31,33) DZUAIKQCQQBQJM-UHFFFAOYSA-N 50466375 CHEMBL4287674 Nuclear receptor ROR-gamma Mus musculus 340 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466375&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 137796283 433933640 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137338 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2cc(ccn2)C#N)cc1 InChI=1S/C26H25FN4O4S/c1-4-36(34,35)20-8-5-17(6-9-20)14-24(32)30-19-7-10-21(22(27)15-19)26(2,3)25(33)31-23-13-18(16-28)11-12-29-23/h5-13,15H,4,14H2,1-3H3,(H,30,32)(H,29,31,33) DUHFUKXNEHGMID-UHFFFAOYSA-N 50466377 CHEMBL4279772 Nuclear receptor ROR-gamma Mus musculus 68 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466377&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145980094 433933642 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137342 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)N(C)c2ccccc2)cc1 InChI=1S/C27H30N2O4S/c1-5-34(32,33)24-17-11-20(12-18-24)19-25(30)28-22-15-13-21(14-16-22)27(2,3)26(31)29(4)23-9-7-6-8-10-23/h6-18H,5,19H2,1-4H3,(H,28,30) GSDTZGJDQDTFBK-UHFFFAOYSA-N 50466384 CHEMBL4293415 Nuclear receptor ROR-gamma Mus musculus 330 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466384&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145987907 433933649 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51137344 CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(cc2)C(C)(C)C(=O)Nc2cc(F)ccn2)cc1 InChI=1S/C25H26FN3O4S/c1-4-34(32,33)21-11-5-17(6-12-21)15-23(30)28-20-9-7-18(8-10-20)25(2,3)24(31)29-22-16-19(26)13-14-27-22/h5-14,16H,4,15H2,1-3H3,(H,28,30)(H,27,29,31) DZNYPAHRQMSYIB-UHFFFAOYSA-N 50466376 CHEMBL4293421 Nuclear receptor ROR-gamma Mus musculus 320 ChEMBL 10.1016/j.bmcl.2018.09.032 10.7270/Q2H997XS 30301676 Sasaki, Y; Odan, M; Yamamoto, S; Kida, S; Ueyama, A; Shimizu, M; Haruna, T; Watanabe, A; Okuno, T Shionogi & Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50466376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50466376&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 145988123 433933641 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51139277 CC(C)C(=O)N1CCC(CC1)c1cn(C)c2ncc(NC(=O)c3cccc(c3)C#N)c(c12)C(F)(F)F InChI=1S/C26H26F3N5O2/c1-15(2)25(36)34-9-7-17(8-10-34)19-14-33(3)23-21(19)22(26(27,28)29)20(13-31-23)32-24(35)18-6-4-5-16(11-18)12-30/h4-6,11,13-15,17H,7-10H2,1-3H3,(H,32,35) BIHPJIJLDNUDGH-UHFFFAOYSA-N 189877 US10227346, Example 5::US10426135, Example 5::US9670201, 5 3-cyano-N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)benzamide::US9920054, Example 5 Nuclear receptor ROR-gamma Mus musculus 32 ChEMBL 10.1021/acs.jmedchem.8b00392 10.7270/Q27P922T 30130103 Schnute, ME; Wennerstål, M; Alley, J; Bengtsson, M; Blinn, JR; Bolten, CW; Braden, T; Bonn, T; Carlsson, B; Caspers, N; Chen, M; Choi, C; Collis, LP; Crouse, K; Färnegårdh, M; Fennell, KF; Fish, S; Flick, AC; Goos-Nilsson, A; Gullberg, H; Harris, PK; Heasley, SE; Hegen, M; Hromockyj, AE; Hu, X; Husman, B; Janosik, T; Jones, P; Kaila, N; Kallin, E; Kauppi, B; Kiefer, JR; Knafels, J; Koehler, K; Kruger, L; Kurumbail, RG; Kyne, RE; Li, W; Löfstedt, J; Long, SA; Menard, CA; Mente, S; Messing, D; Meyers, MJ; Napierata, L; Nöteberg, D; Nuhant, P; Pelc, MJ; Prinsen, MJ; Rhönnstad, P; Backström-Rydin, E; Sandberg, J; Sandström, M; Shah, F; Sjöberg, M; Sundell, A; Taylor, AP; Thorarensen, A; Trujillo, JI; Trzupek, JD; Unwalla, R; Vajdos, FF; Weinberg, RA; Wood, DC; Xing, L; Zamaratski, E; Zapf, CW; Zhao, Y; Wilhelmsson, A; Berstein, G Karo Bio AB (now Karo Pharma AB) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=189877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=189877&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118977746 373987799 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51253405 OC(=O)c1ccc(cc1)-n1cc(C(=O)c2c(Cl)cccc2Cl)c2ccccc12 InChI=1S/C22H13Cl2NO3/c23-17-5-3-6-18(24)20(17)21(26)16-12-25(19-7-2-1-4-15(16)19)14-10-8-13(9-11-14)22(27)28/h1-12H,(H,27,28) MYHNQIQWDRXLHS-UHFFFAOYSA-N 50512490 CHEMBL4454027 Nuclear receptor ROR-gamma Mus musculus 58 ChEMBL 10.1016/j.bmcl.2019.06.044 10.7270/Q2D50R96 31272795 Shaikh, NS; Iyer, JP; Munot, YS; Mukhopadhyay, PP; Raje, AA; Nagaraj, R; Jamdar, V; Gavhane, R; Lohote, M; Sherkar, P; Bala, M; Petla, R; Meru, A; Umrani, D; Rouduri, S; Joshi, S; Reddy, S; Kandikere, V; Bhuniya, D; Kulkarni, B; Mookhtiar, KA Advinus Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50512490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50512490&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 118142047 440721072 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51253492 OC(=O)c1ccc(cc1)-n1cc(C(=O)c2c(Cl)cccc2Cl)c2cccc(F)c12 InChI=1S/C22H12Cl2FNO3/c23-16-4-2-5-17(24)19(16)21(27)15-11-26(20-14(15)3-1-6-18(20)25)13-9-7-12(8-10-13)22(28)29/h1-11H,(H,28,29) IUHZJIRXCFINGV-UHFFFAOYSA-N 364370 4-[3-(2,6-dichlorobenzoyl)-7-fluoro-1H-indol-1-yl]benzoic acid::US9861612, Comparator 3 Nuclear receptor ROR-gamma Mus musculus 500 ChEMBL 10.1016/j.bmcl.2019.06.044 10.7270/Q2D50R96 31272795 Shaikh, NS; Iyer, JP; Munot, YS; Mukhopadhyay, PP; Raje, AA; Nagaraj, R; Jamdar, V; Gavhane, R; Lohote, M; Sherkar, P; Bala, M; Petla, R; Meru, A; Umrani, D; Rouduri, S; Joshi, S; Reddy, S; Kandikere, V; Bhuniya, D; Kulkarni, B; Mookhtiar, KA Advinus Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=364370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=364370&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121470704 401959806 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51253493 OC(=O)c1ccc(cc1)-n1cc(C(=O)c2c(Cl)cccc2Cl)c2cccc(F)c12 InChI=1S/C22H12Cl2FNO3/c23-16-4-2-5-17(24)19(16)21(27)15-11-26(20-14(15)3-1-6-18(20)25)13-9-7-12(8-10-13)22(28)29/h1-11H,(H,28,29) IUHZJIRXCFINGV-UHFFFAOYSA-N 364370 4-[3-(2,6-dichlorobenzoyl)-7-fluoro-1H-indol-1-yl]benzoic acid::US9861612, Comparator 3 Nuclear receptor ROR-gamma Mus musculus 26 ChEMBL 10.1016/j.bmcl.2019.06.044 10.7270/Q2D50R96 31272795 Shaikh, NS; Iyer, JP; Munot, YS; Mukhopadhyay, PP; Raje, AA; Nagaraj, R; Jamdar, V; Gavhane, R; Lohote, M; Sherkar, P; Bala, M; Petla, R; Meru, A; Umrani, D; Rouduri, S; Joshi, S; Reddy, S; Kandikere, V; Bhuniya, D; Kulkarni, B; Mookhtiar, KA Advinus Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=364370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=364370&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121470704 401959806 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51253499 OC(=O)c1ccc(cc1)-c1nn(C(=O)c2c(Cl)cccc2Cl)c2ccccc12 InChI=1S/C21H12Cl2N2O3/c22-15-5-3-6-16(23)18(15)20(26)25-17-7-2-1-4-14(17)19(24-25)12-8-10-13(11-9-12)21(27)28/h1-11H,(H,27,28) YRLYJWZLPGDXGP-UHFFFAOYSA-N 50203542 CHEMBL3218921 Nuclear receptor ROR-gamma Mus musculus 43 ChEMBL 10.1016/j.bmcl.2019.06.044 10.7270/Q2D50R96 31272795 Shaikh, NS; Iyer, JP; Munot, YS; Mukhopadhyay, PP; Raje, AA; Nagaraj, R; Jamdar, V; Gavhane, R; Lohote, M; Sherkar, P; Bala, M; Petla, R; Meru, A; Umrani, D; Rouduri, S; Joshi, S; Reddy, S; Kandikere, V; Bhuniya, D; Kulkarni, B; Mookhtiar, KA Advinus Therapeutics Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50203542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50203542&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 60162553 375980119 CHEMBL3218921 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51244435 OC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO6S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-36(22(37)23(38)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,38H,1,8-14H2/t21-,24-/m1/s1 ONXFNBOZJKXCNC-ZJSXRUAMSA-N 382356 US10273259, Example 69::US10711020, Example 69 Nuclear receptor ROR-gamma Mus musculus 13 ChEMBL 10.1021/acs.jmedchem.9b01369 10.7270/Q2G44TKD 31638797 Marcoux, D; Duan, JJ; Shi, Q; Cherney, RJ; Srivastava, AS; Cornelius, L; Batt, DG; Liu, Q; Beaudoin-Bertrand, M; Weigelt, CA; Khandelwal, P; Vishwakrishnan, S; Selvakumar, K; Karmakar, A; Gupta, AK; Basha, M; Ramlingam, S; Manjunath, N; Vanteru, S; Karmakar, S; Maddala, N; Vetrichelvan, M; Gupta, A; Rampulla, RA; Mathur, A; Yip, S; Li, P; Wu, DR; Khan, J; Ruzanov, M; Sack, JS; Wang, J; Yarde, M; Cvijic, ME; Li, S; Shuster, DJ; Borowski, V; Xie, JH; McIntyre, KW; Obermeier, MT; Fura, A; Stefanski, K; Cornelius, G; Hynes, J; Tino, JA; Macor, JE; Salter-Cid, L; Denton, R; Zhao, Q; Carter, PH; Dhar, TGM Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382356&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669265 404851728 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51245701 O=C(Nc1ccc2CCC(N3CCN(CC3)C(=O)C3CCCC3)c2c1)c1cccc(c1)C#N InChI=1S/C27H30N4O2/c28-18-19-4-3-7-22(16-19)26(32)29-23-10-8-20-9-11-25(24(20)17-23)30-12-14-31(15-13-30)27(33)21-5-1-2-6-21/h3-4,7-8,10,16-17,21,25H,1-2,5-6,9,11-15H2,(H,29,32) IFMBQSHDQFIUGG-UHFFFAOYSA-N 50509676 CHEMBL4533097 Nuclear receptor ROR-gamma Mus musculus 2661 ChEMBL 10.1016/j.ejmech.2019.01.082 10.7270/Q23R0X5J 30743096 Tian, J; Sun, N; Yu, M; Gu, X; Xie, Q; Shao, L; Liu, J; Liu, L; Wang, Y Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509676&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155547762 440718261 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51245702 O=C(Nc1cccc2C(CCc12)N1CCN(CC1)C(=O)C1CCCC1)c1cccc(c1)C#N InChI=1S/C27H30N4O2/c28-18-19-5-3-8-21(17-19)26(32)29-24-10-4-9-23-22(24)11-12-25(23)30-13-15-31(16-14-30)27(33)20-6-1-2-7-20/h3-5,8-10,17,20,25H,1-2,6-7,11-16H2,(H,29,32) YYMICDVHCXFIBG-UHFFFAOYSA-N 50509677 CHEMBL4439289 Nuclear receptor ROR-gamma Mus musculus 1783 ChEMBL 10.1016/j.ejmech.2019.01.082 10.7270/Q23R0X5J 30743096 Tian, J; Sun, N; Yu, M; Gu, X; Xie, Q; Shao, L; Liu, J; Liu, L; Wang, Y Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509677&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155513917 440718262 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51245703 O=C(C1CCCC1)N1C2CCC1CN(C2)C1CCc2ccc(NC(=O)c3cccc(c3)C#N)cc12 InChI=1S/C29H32N4O2/c30-16-19-4-3-7-22(14-19)28(34)31-23-10-8-20-9-13-27(26(20)15-23)32-17-24-11-12-25(18-32)33(24)29(35)21-5-1-2-6-21/h3-4,7-8,10,14-15,21,24-25,27H,1-2,5-6,9,11-13,17-18H2,(H,31,34) KYGDDUXGUSBEGS-UHFFFAOYSA-N 50509678 CHEMBL4474340 Nuclear receptor ROR-gamma Mus musculus 423 ChEMBL 10.1016/j.ejmech.2019.01.082 10.7270/Q23R0X5J 30743096 Tian, J; Sun, N; Yu, M; Gu, X; Xie, Q; Shao, L; Liu, J; Liu, L; Wang, Y Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509678&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155536831 440718263 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51245704 O=C(Nc1ccc2CCC(N3CC4CCC(C3)N4C(=O)C3CCCCC3)c2c1)c1cccc(c1)C#N InChI=1S/C30H34N4O2/c31-17-20-5-4-8-23(15-20)29(35)32-24-11-9-21-10-14-28(27(21)16-24)33-18-25-12-13-26(19-33)34(25)30(36)22-6-2-1-3-7-22/h4-5,8-9,11,15-16,22,25-26,28H,1-3,6-7,10,12-14,18-19H2,(H,32,35) NTZZWMTWMXXRTL-UHFFFAOYSA-N 50509679 CHEMBL4436338 Nuclear receptor ROR-gamma Mus musculus 106 ChEMBL 10.1016/j.ejmech.2019.01.082 10.7270/Q23R0X5J 30743096 Tian, J; Sun, N; Yu, M; Gu, X; Xie, Q; Shao, L; Liu, J; Liu, L; Wang, Y Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509679&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155511896 440718264 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51245705 O=C(Nc1ccc2CC[C@H](N3CC4CCC(C3)N4C(=O)C3CCCCC3)c2c1)c1cccc(c1)C#N InChI=1S/C30H34N4O2/c31-17-20-5-4-8-23(15-20)29(35)32-24-11-9-21-10-14-28(27(21)16-24)33-18-25-12-13-26(19-33)34(25)30(36)22-6-2-1-3-7-22/h4-5,8-9,11,15-16,22,25-26,28H,1-3,6-7,10,12-14,18-19H2,(H,32,35)/t25?,26?,28-/m0/s1 NTZZWMTWMXXRTL-ZRZZZMTFSA-N 50509680 CHEMBL4468864 Nuclear receptor ROR-gamma Mus musculus 47 ChEMBL 10.1016/j.ejmech.2019.01.082 10.7270/Q23R0X5J 30743096 Tian, J; Sun, N; Yu, M; Gu, X; Xie, Q; Shao, L; Liu, J; Liu, L; Wang, Y Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509680&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155533435 440718265 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51245720 O=C(C1CCCC1)N1C2CCC1CN(C2)C1CCc2c1cccc2NC(=O)c1cccc(c1)C#N InChI=1S/C29H32N4O2/c30-16-19-5-3-8-21(15-19)28(34)31-26-10-4-9-25-24(26)13-14-27(25)32-17-22-11-12-23(18-32)33(22)29(35)20-6-1-2-7-20/h3-5,8-10,15,20,22-23,27H,1-2,6-7,11-14,17-18H2,(H,31,34) LCRDFCJAMPHTFT-UHFFFAOYSA-N 50509693 CHEMBL4576701 Nuclear receptor ROR-gamma Mus musculus 385 ChEMBL 10.1016/j.ejmech.2019.01.082 10.7270/Q23R0X5J 30743096 Tian, J; Sun, N; Yu, M; Gu, X; Xie, Q; Shao, L; Liu, J; Liu, L; Wang, Y Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50509693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50509693&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155553746 440718278 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51244548 OC1(CCS(=O)(=O)CC1)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C27H25F8NO6S2/c28-18-3-5-19(6-4-18)44(41,42)24-9-12-36(22(37)23(38)10-13-43(39,40)14-11-23)21(24)8-1-16-15-17(2-7-20(16)24)25(29,26(30,31)32)27(33,34)35/h2-7,15,21,38H,1,8-14H2/t21-,24-/m1/s1 ONXFNBOZJKXCNC-ZJSXRUAMSA-N 382356 US10273259, Example 69::US10711020, Example 69 Nuclear receptor ROR-gamma Mus musculus 440 ChEMBL 10.1021/acs.jmedchem.9b01369 10.7270/Q2G44TKD 31638797 Marcoux, D; Duan, JJ; Shi, Q; Cherney, RJ; Srivastava, AS; Cornelius, L; Batt, DG; Liu, Q; Beaudoin-Bertrand, M; Weigelt, CA; Khandelwal, P; Vishwakrishnan, S; Selvakumar, K; Karmakar, A; Gupta, AK; Basha, M; Ramlingam, S; Manjunath, N; Vanteru, S; Karmakar, S; Maddala, N; Vetrichelvan, M; Gupta, A; Rampulla, RA; Mathur, A; Yip, S; Li, P; Wu, DR; Khan, J; Ruzanov, M; Sack, JS; Wang, J; Yarde, M; Cvijic, ME; Li, S; Shuster, DJ; Borowski, V; Xie, JH; McIntyre, KW; Obermeier, MT; Fura, A; Stefanski, K; Cornelius, G; Hynes, J; Tino, JA; Macor, JE; Salter-Cid, L; Denton, R; Zhao, Q; Carter, PH; Dhar, TGM Bristol-Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=382356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=382356&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 122669265 404851728 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51222661 CCS(=O)(=O)c1ccc(cc1)[C@H](NC(C)=O)C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C21H20F6N2O5S/c1-3-35(33,34)16-10-4-13(5-11-16)17(28-12(2)30)18(31)29-15-8-6-14(7-9-15)19(32,20(22,23)24)21(25,26)27/h4-11,17,32H,3H2,1-2H3,(H,28,30)(H,29,31)/t17-/m0/s1 HJJYGXDBXQAVQG-KRWDZBQOSA-N 50502394 CHEMBL4445354 Nuclear receptor ROR-gamma Mus musculus 3981 ChEMBL 10.1021/acsmedchemlett.9b00158 10.7270/Q2736V64 31223457 von Berg, S; Xue, Y; Collins, M; Llinas, A; Olsson, RI; Halvarsson, T; Lindskog, M; Malmberg, J; Jirholt, J; Krutrök, N; Ramnegård, M; Brännström, M; Lundqvist, A; Lepistö, M; Aagaard, A; McPheat, J; Hansson, EL; Chen, R; Xiong, Y; Hansson, TG; Narjes, F AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502394&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155517869 440710979 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51222685 CCS(=O)(=O)c1ccc(cc1)[C@@H](NC(C)=O)C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C21H20F6N2O5S/c1-3-35(33,34)16-10-4-13(5-11-16)17(28-12(2)30)18(31)29-15-8-6-14(7-9-15)19(32,20(22,23)24)21(25,26)27/h4-11,17,32H,3H2,1-2H3,(H,28,30)(H,29,31)/t17-/m1/s1 HJJYGXDBXQAVQG-QGZVFWFLSA-N 50502393 CHEMBL4562895 Nuclear receptor ROR-gamma Mus musculus 126 ChEMBL 10.1021/acsmedchemlett.9b00158 10.7270/Q2736V64 31223457 von Berg, S; Xue, Y; Collins, M; Llinas, A; Olsson, RI; Halvarsson, T; Lindskog, M; Malmberg, J; Jirholt, J; Krutrök, N; Ramnegård, M; Brännström, M; Lundqvist, A; Lepistö, M; Aagaard, A; McPheat, J; Hansson, EL; Chen, R; Xiong, Y; Hansson, TG; Narjes, F AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502393&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search JUN 6R7J 138454290 440710978 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51222693 CCS(=O)(=O)c1ccc(cc1)C(NC(=O)Cc1ccccc1)C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C27H24F6N2O5S/c1-2-41(39,40)21-14-8-18(9-15-21)23(35-22(36)16-17-6-4-3-5-7-17)24(37)34-20-12-10-19(11-13-20)25(38,26(28,29)30)27(31,32)33/h3-15,23,38H,2,16H2,1H3,(H,34,37)(H,35,36) YNDQSYNAWXKDSD-UHFFFAOYSA-N 50502387 CHEMBL4458320 Nuclear receptor ROR-gamma Mus musculus 25 ChEMBL 10.1021/acsmedchemlett.9b00158 10.7270/Q2736V64 31223457 von Berg, S; Xue, Y; Collins, M; Llinas, A; Olsson, RI; Halvarsson, T; Lindskog, M; Malmberg, J; Jirholt, J; Krutrök, N; Ramnegård, M; Brännström, M; Lundqvist, A; Lepistö, M; Aagaard, A; McPheat, J; Hansson, EL; Chen, R; Xiong, Y; Hansson, TG; Narjes, F AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502387 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502387&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search JUH 6R7K 155526875 440710972 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51338696 C[C@H]1C[C@@H](CC[C@H]1C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-14-18(26(41)42)2-9-22(16)25(40)39-13-12-27(45(43,44)21-7-5-20(31)6-8-21)23-10-4-19(15-17(23)3-11-24(27)39)28(32,29(33,34)35)30(36,37)38/h4-8,10,15-16,18,22,24H,2-3,9,11-14H2,1H3,(H,41,42)/t16-,18+,22+,24+,27+/m0/s1 JQORWGARJVSRBA-QOTTZFGFSA-N 50541922 Bms-986251 Nuclear receptor ROR-gamma Mus musculus 11 ChEMBL 10.1021/acsmedchemlett.0c00063 10.7270/Q2TH8R8Z 32551004 Cherney, RJ; Cornelius, LAM; Srivastava, A; Weigelt, CA; Marcoux, D; Duan, JJ; Shi, Q; Batt, DG; Liu, Q; Yip, S; Wu, DR; Ruzanov, M; Sack, J; Khan, J; Wang, J; Yarde, M; Cvijic, ME; Mathur, A; Li, S; Shuster, D; Khandelwal, P; Borowski, V; Xie, J; Obermeier, M; Fura, A; Stefanski, K; Cornelius, G; Tino, JA; Macor, JE; Salter-Cid, L; Denton, R; Zhao, Q; Carter, PH; Dhar, TGM Bristol Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50541922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50541922&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search R7V 6VQF 132123624 442143485 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343052 C[C@H](NS(=O)(=O)c1ccc(-c2sc(CC(C)(C)C(O)=O)nc2CC2CCC2)c(Cl)c1Cl)C(F)(F)F InChI=1S/C22H25Cl2F3N2O4S2/c1-11(22(25,26)27)29-35(32,33)15-8-7-13(17(23)18(15)24)19-14(9-12-5-4-6-12)28-16(34-19)10-21(2,3)20(30)31/h7-8,11-12,29H,4-6,9-10H2,1-3H3,(H,30,31)/t11-/m0/s1 BNMRBSLYMNBOOG-NSHDSACASA-N 50543663 CHEMBL4647734 Nuclear receptor ROR-gamma Mus musculus 1870 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543663&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 156020502 442145226 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343069 CC[C@H](NS(=O)(=O)c1ccc(-c2sc(CC(C)(C)C(O)=O)nc2CC2CCC2)c(C(F)F)c1F)C(F)(F)F InChI=1S/C24H28F6N2O4S2/c1-4-16(24(28,29)30)32-38(35,36)15-9-8-13(18(19(15)25)21(26)27)20-14(10-12-6-5-7-12)31-17(37-20)11-23(2,3)22(33)34/h8-9,12,16,21,32H,4-7,10-11H2,1-3H3,(H,33,34)/t16-/m0/s1 UHGQXGAUHHFUOQ-INIZCTEOSA-N 50543667 CHEMBL4641138 Nuclear receptor ROR-gamma Mus musculus 2500 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543667&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 156016034 442145230 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343077 C[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCC2)-c2noc(CC(C)(C)C(O)=O)n2)c(Cl)c1Cl)C(F)(F)F InChI=1S/C24H25Cl2F3N4O5S2/c1-11(24(27,28)29)33-40(36,37)15-8-7-13(17(25)18(15)26)19-14(9-12-5-4-6-12)30-21(39-19)20-31-16(38-32-20)10-23(2,3)22(34)35/h7-8,11-12,33H,4-6,9-10H2,1-3H3,(H,34,35)/t11-/m0/s1 KIAHYBIZSGNTBR-NSHDSACASA-N 50543668 CHEMBL4632527 Nuclear receptor ROR-gamma Mus musculus 790 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543668&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121302041 442145231 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343106 CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCC2)-c2nnc(CC(C)(C)C(O)=O)o2)c(C(F)F)c1F)C(F)(F)F InChI=1S/C27H30F6N4O5S2/c1-4-17(27(31,32)33)37-44(40,41)16-10-9-14(19(20(16)28)22(29)30)21-15(11-13-7-5-6-8-13)34-24(43-21)23-36-35-18(42-23)12-26(2,3)25(38)39/h9-10,13,17,22,37H,4-8,11-12H2,1-3H3,(H,38,39)/t17-/m0/s1 ILHSEFVQHFQLRM-KRWDZBQOSA-N 285771 US10080744, Example 3/38 Nuclear receptor ROR-gamma Mus musculus 230 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285771&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121301949 378169409 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343112 CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CC2CCCCC2)-c2nnc(CC(C)(C)C(O)=O)o2)c(C(F)F)c1F)C(F)(F)F InChI=1S/C28H32F6N4O5S2/c1-4-18(28(32,33)34)38-45(41,42)17-11-10-15(20(21(17)29)23(30)31)22-16(12-14-8-6-5-7-9-14)35-25(44-22)24-37-36-19(43-24)13-27(2,3)26(39)40/h10-11,14,18,23,38H,4-9,12-13H2,1-3H3,(H,39,40)/t18-/m0/s1 ZHSFCHXKHOJYIG-SFHVURJKSA-N 285759 US10080744, Example 3/26 Nuclear receptor ROR-gamma Mus musculus 1539 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=285759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=285759&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121301997 378169397 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343127 COC(C)(C)Cc1nc(sc1-c1ccc(c(F)c1C(F)F)S(=O)(=O)N[C@@H](C)C(F)(F)F)-c1nnc(CC(C)(C)C(O)=O)o1 InChI=1S/C25H28F6N4O6S2/c1-11(25(29,30)31)35-43(38,39)14-8-7-12(16(17(14)26)19(27)28)18-13(9-24(4,5)40-6)32-21(42-18)20-34-33-15(41-20)10-23(2,3)22(36)37/h7-8,11,19,35H,9-10H2,1-6H3,(H,36,37)/t11-/m0/s1 VHGGVTVFPZUWCU-NSHDSACASA-N 50543675 CHEMBL4641039 Nuclear receptor ROR-gamma Mus musculus 9000 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543675&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 156015132 442145238 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343133 C[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2CN2CCCC(F)(F)C2)-c2nnc(CC(C)(C)C(O)=O)o2)c(C(F)F)c1F)C(F)(F)F InChI=1S/C26H27F8N5O5S2/c1-12(26(32,33)34)38-46(42,43)15-6-5-13(17(18(15)27)20(28)29)19-14(10-39-8-4-7-25(30,31)11-39)35-22(45-19)21-37-36-16(44-21)9-24(2,3)23(40)41/h5-6,12,20,38H,4,7-11H2,1-3H3,(H,40,41)/t12-/m0/s1 SBHFAQDIXHCJBY-LBPRGKRZSA-N 50543676 CHEMBL4642674 Nuclear receptor ROR-gamma Mus musculus 448 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543676&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 156016818 442145239 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343145 CCN(CC)C(=O)c1nc(sc1-c1ccc(c(Cl)c1Cl)S(=O)(=O)N[C@@H](C)C(F)(F)F)-c1nnc(o1)C(C)(C)O InChI=1S/C22H24Cl2F3N5O5S2/c1-6-32(7-2)19(33)15-16(38-18(28-15)17-29-30-20(37-17)21(4,5)34)11-8-9-12(14(24)13(11)23)39(35,36)31-10(3)22(25,26)27/h8-10,31,34H,6-7H2,1-5H3/t10-/m0/s1 TZBMJMWWRPOUKP-JTQLQIEISA-N 50543679 CHEMBL4648849 Nuclear receptor ROR-gamma Mus musculus 100 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543679&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121303961 442145242 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343150 C[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2C(=O)N2CCC(F)(F)CC2)-c2nnc(o2)C(C)(C)O)c(Cl)c1Cl)C(F)(F)F InChI=1S/C23H22Cl2F5N5O5S2/c1-10(23(28,29)30)34-42(38,39)12-5-4-11(13(24)14(12)25)16-15(19(36)35-8-6-22(26,27)7-9-35)31-18(41-16)17-32-33-20(40-17)21(2,3)37/h4-5,10,34,37H,6-9H2,1-3H3/t10-/m0/s1 DPLDVWYMOZMXLB-JTQLQIEISA-N 50543680 CHEMBL4649427 Nuclear receptor ROR-gamma Mus musculus 196 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543680&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121303949 442145243 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51343161 CC[C@H](NS(=O)(=O)c1ccc(-c2sc(nc2C(=O)N2CCC(F)CC2)-c2nnc(CC(C)(C)O)o2)c(Cl)c1Cl)C(F)(F)F InChI=1S/C25H27Cl2F4N5O5S2/c1-4-15(25(29,30)31)35-43(39,40)14-6-5-13(17(26)18(14)27)20-19(23(37)36-9-7-12(28)8-10-36)32-22(42-20)21-34-33-16(41-21)11-24(2,3)38/h5-6,12,15,35,38H,4,7-11H2,1-3H3/t15-/m0/s1 VWOLTHFSWIIFKC-HNNXBMFYSA-N 50543682 CHEMBL4642733 Nuclear receptor ROR-gamma Mus musculus 120 ChEMBL 10.1016/j.bmcl.2020.127174 10.7270/Q2862M1T 32334912 Steeneck, C; Gege, C; Kinzel, O; Albers, M; Kleymann, G; Schlüter, T; Schulz, A; Xue, X; Cummings, MD; Fourie, AM; Leonard, KA; Scott, B; Edwards, JP; Hoffmann, T; Goldberg, SD Phenex Pharmaceuticals AG http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50543682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50543682&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 121303788 442145245 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51348632 C[C@@]1(CC[C@@H](CC1)C(O)=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(OCc3c(F)cccc3C(F)(F)F)ccc21)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C35H34F5NO6S/c1-33(15-13-21(14-16-33)31(42)43)32(44)41-18-17-34(48(45,46)25-9-6-23(36)7-10-25)27-11-8-24(19-22(27)5-12-30(34)41)47-20-26-28(35(38,39)40)3-2-4-29(26)37/h2-4,6-11,19,21,30H,5,12-18,20H2,1H3,(H,42,43)/t21-,30-,33-,34-/m1/s1 IQMRENBCQAZPJJ-IOHSOSRPSA-N 50545542 CHEMBL4641912 Nuclear receptor ROR-gamma Mus musculus 380 ChEMBL 10.1016/j.bmcl.2020.127204 10.7270/Q2GX4G5T 32334911 Harikrishnan, LS; Gill, P; Kamau, MG; Qin, LY; Ruan, Z; O'Malley, D; Huynh, T; Stachura, S; Cavallaro, CL; Lu, Z; J-W Duan, J; Weigelt, CA; Sack, JS; Ruzanov, M; Khan, J; Gururajan, M; Wong, JJ; Huang, Y; Yarde, M; Li, Z; Chen, C; Sun, H; Borowski, V; Murtaza, A; Fink, BE Bristol Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50545542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50545542&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155307891 442111353 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51366926 COc1ccc(Oc2c(Cl)cc(NC(=O)CN3CCN(CC3)S(C)(=O)=O)cc2Cl)cc1C(C)C InChI=1S/C23H29Cl2N3O5S/c1-15(2)18-13-17(5-6-21(18)32-3)33-23-19(24)11-16(12-20(23)25)26-22(29)14-27-7-9-28(10-8-27)34(4,30)31/h5-6,11-13,15H,7-10,14H2,1-4H3,(H,26,29) UCRLIXAPWLBGMA-UHFFFAOYSA-N 50552534 CHEMBL4777230 Nuclear receptor ROR-gamma Mus musculus 34 ChEMBL 10.1016/j.bmcl.2021.127778 10.7270/Q2Q52T84 33422603 Ruan, Z; Park, PK; Wei, D; Purandare, A; Wan, H; O'Malley, D; Stachura, S; Perez, H; Cavallaro, CL; Weigelt, CA; Sack, JS; Ruzanov, M; Khan, J; Gururajan, M; Wong, JJ; Huang, Y; Yarde, M; Li, Z; Chen, C; Sun, H; Borowski, V; Xie, JH; Anthony, M; Agler, M; Fink, BE; Harikrishnan, LS Bristol Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50552534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50552534&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155781677 461682874 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51366927 COc1ncc(Oc2c(Cl)cc(NC(=O)CC3CCN(CC3)S(C)(=O)=O)cc2Cl)cc1C(C)C InChI=1S/C23H29Cl2N3O5S/c1-14(2)18-12-17(13-26-23(18)32-3)33-22-19(24)10-16(11-20(22)25)27-21(29)9-15-5-7-28(8-6-15)34(4,30)31/h10-15H,5-9H2,1-4H3,(H,27,29) CMWKFXBFRJPOBS-UHFFFAOYSA-N 50552535 CHEMBL4796044 Nuclear receptor ROR-gamma Mus musculus 30 ChEMBL 10.1016/j.bmcl.2021.127778 10.7270/Q2Q52T84 33422603 Ruan, Z; Park, PK; Wei, D; Purandare, A; Wan, H; O'Malley, D; Stachura, S; Perez, H; Cavallaro, CL; Weigelt, CA; Sack, JS; Ruzanov, M; Khan, J; Gururajan, M; Wong, JJ; Huang, Y; Yarde, M; Li, Z; Chen, C; Sun, H; Borowski, V; Xie, JH; Anthony, M; Agler, M; Fink, BE; Harikrishnan, LS Bristol Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50552535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50552535&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search Z7I 7KXF 155295787 461682875 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51366928 COc1ccc(Oc2c(Cl)cc(NC(=O)Cc3ccncc3)cc2Cl)cc1C(C)C InChI=1S/C23H22Cl2N2O3/c1-14(2)18-13-17(4-5-21(18)29-3)30-23-19(24)11-16(12-20(23)25)27-22(28)10-15-6-8-26-9-7-15/h4-9,11-14H,10H2,1-3H3,(H,27,28) NPIGEOLECVWXHK-UHFFFAOYSA-N 50552552 CHEMBL4783024 Nuclear receptor ROR-gamma Mus musculus 81 ChEMBL 10.1016/j.bmcl.2021.127778 10.7270/Q2Q52T84 33422603 Ruan, Z; Park, PK; Wei, D; Purandare, A; Wan, H; O'Malley, D; Stachura, S; Perez, H; Cavallaro, CL; Weigelt, CA; Sack, JS; Ruzanov, M; Khan, J; Gururajan, M; Wong, JJ; Huang, Y; Yarde, M; Li, Z; Chen, C; Sun, H; Borowski, V; Xie, JH; Anthony, M; Agler, M; Fink, BE; Harikrishnan, LS Bristol Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50552552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50552552&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 155781898 461682892 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51373760 CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C24H31N3O3S/c1-20(28)25-14-16-26(17-15-25)23-12-10-21(11-13-23)18-27(24-8-5-9-24)31(29,30)19-22-6-3-2-4-7-22/h2-4,6-7,10-13,24H,5,8-9,14-19H2,1H3 KIHDXHLXSMPQSN-UHFFFAOYSA-N 50050086 CHEMBL3317836::US9216988, 55 Nuclear receptor ROR-gamma Mus musculus 670 ChEMBL 10.1016/j.ejmech.2019.111984 10.7270/Q2668HTJ 31881455 Sun, N; Ma, X; Zhou, K; Zhu, C; Cao, Z; Wang, Y; Xu, J; Fu, W Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50050086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50050086&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 86690644 103947273 CHEMBL3317836 ZINC25965335 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51373761 CN(Cc1ccccc1)S(=O)(=O)N1CCCc2cc(ccc12)N1CCN(CC1)C(C)=O InChI=1S/C23H30N4O3S/c1-19(28)25-13-15-26(16-14-25)22-10-11-23-21(17-22)9-6-12-27(23)31(29,30)24(2)18-20-7-4-3-5-8-20/h3-5,7-8,10-11,17H,6,9,12-16,18H2,1-2H3 HGIVSBUXSHCSJC-UHFFFAOYSA-N 50555594 CHEMBL4745031 Nuclear receptor ROR-gamma Mus musculus 4930 ChEMBL 10.1016/j.ejmech.2019.111984 10.7270/Q2668HTJ 31881455 Sun, N; Ma, X; Zhou, K; Zhu, C; Cao, Z; Wang, Y; Xu, J; Fu, W Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50555594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50555594&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 162648823 461694362 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51369268 C[C@H]1C[C@@H](CC[C@H]1C(=O)N1CC[C@@]2([C@H]1CCc1cc(c(F)cc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccccc1)C(O)=O InChI=1S/C30H29F8NO5S/c1-16-13-18(26(41)42)7-9-20(16)25(40)39-12-11-27(45(43,44)19-5-3-2-4-6-19)21-15-23(31)22(14-17(21)8-10-24(27)39)28(32,29(33,34)35)30(36,37)38/h2-6,14-16,18,20,24H,7-13H2,1H3,(H,41,42)/t16-,18+,20+,24+,27+/m0/s1 ZRBKKZYWZRWOFL-GSDLGJSISA-N 50553584 CHEMBL4763134 Nuclear receptor ROR-gamma Mus musculus 2.0 ChEMBL 10.1016/j.bmcl.2020.127521 10.7270/Q2SN0DMB 32882417 Shi, Q; Xiao, Z; Yang, MG; Marcoux, D; Cherney, RJ; Yip, S; Li, P; Wu, DR; Weigelt, CA; Sack, J; Khan, J; Ruzanov, M; Wang, J; Yarde, M; Ellen Cvijic, M; Li, S; Shuster, DJ; Xie, J; Sherry, T; Obermeier, M; Fura, A; Stefanski, K; Cornelius, G; Chacko, S; Shu, YZ; Khandelwal, P; Hynes, J; Tino, JA; Salter-Cid, L; Denton, R; Zhao, Q; Dhar, TGM Bristol Myers Squibb http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553584&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 146257125 461692352 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51354721 CC(C)(O)CN1[C@@H](C[C@@H](F)C1=O)C(=O)N1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C30H29F9N2O5S/c1-26(2,44)15-41-22(14-21(32)24(41)42)25(43)40-12-11-27(47(45,46)19-7-5-18(31)6-8-19)20-9-4-17(13-16(20)3-10-23(27)40)28(33,29(34,35)36)30(37,38)39/h4-9,13,21-23,44H,3,10-12,14-15H2,1-2H3/t21-,22+,23-,27-/m1/s1 NETWYXYMXZLUOG-QSGNWFJVSA-N 50548025 CHEMBL4782326 Nuclear receptor ROR-gamma Mus musculus 43 ChEMBL 10.1021/acsmedchemlett.0c00496 10.7270/Q2MS3XBX 33335675 Liu, Q; Batt, DG; Weigelt, CA; Yip, S; Wu, DR; Ruzanov, M; Sack, JS; Wang, J; Yarde, M; Li, S; Shuster, DJ; Xie, JH; Sherry, T; Obermeier, MT; Fura, A; Stefanski, K; Cornelius, G; Khandelwal, P; Tino, JA; Macor, JE; Salter-Cid, L; Denton, R; Zhao, Q; Dhar, TGM Bristol Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548025&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search Z8I 7JYM 155289164 461678365 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51417629 CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccccc2)cc1 InChI=1S/C24H31N3O3S/c1-20(28)25-14-16-26(17-15-25)23-12-10-21(11-13-23)18-27(24-8-5-9-24)31(29,30)19-22-6-3-2-4-7-22/h2-4,6-7,10-13,24H,5,8-9,14-19H2,1H3 KIHDXHLXSMPQSN-UHFFFAOYSA-N 50050086 CHEMBL3317836::US9216988, 55 Nuclear receptor ROR-gamma Mus musculus 760 ChEMBL 10.1016/j.ejmech.2021.113585 10.7270/Q2S75M5R 34118722 Ma, X; Sun, N; Li, X; Fu, W Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50050086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50050086&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 86690644 103947273 CHEMBL3317836 ZINC25965335 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51417630 CN(Cc1ccccc1C(F)(F)F)S(=O)(=O)N1CCc2cc(ccc2C1)N1CCN(CC1)C(C)=O InChI=1S/C24H29F3N4O3S/c1-18(32)29-11-13-30(14-12-29)22-8-7-20-17-31(10-9-19(20)15-22)35(33,34)28(2)16-21-5-3-4-6-23(21)24(25,26)27/h3-8,15H,9-14,16-17H2,1-2H3 FCXQRWNSSFAJRQ-UHFFFAOYSA-N 50572706 CHEMBL4855370 Nuclear receptor ROR-gamma Mus musculus 1120 ChEMBL 10.1016/j.ejmech.2021.113585 10.7270/Q2S75M5R 34118722 Ma, X; Sun, N; Li, X; Fu, W Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50572706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50572706&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 164609680 471062851 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51417631 CN(Cc1ccccc1Cl)S(=O)(=O)N1CCc2cc(ccc2C1)N1CCN(CC1)C(C)=O InChI=1S/C23H29ClN4O3S/c1-18(29)26-11-13-27(14-12-26)22-8-7-20-17-28(10-9-19(20)15-22)32(30,31)25(2)16-21-5-3-4-6-23(21)24/h3-8,15H,9-14,16-17H2,1-2H3 SDCIYORPRRQGKG-UHFFFAOYSA-N 50572707 CHEMBL4846610 Nuclear receptor ROR-gamma Mus musculus 230 ChEMBL 10.1016/j.ejmech.2021.113585 10.7270/Q2S75M5R 34118722 Ma, X; Sun, N; Li, X; Fu, W Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50572707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50572707&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 164608739 471062852 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51417632 CN(Cc1c(F)cccc1Cl)S(=O)(=O)N1CCc2cc(ccc2C1)N1CCN(CC1)C(C)=O InChI=1S/C23H28ClFN4O3S/c1-17(30)27-10-12-28(13-11-27)20-7-6-19-15-29(9-8-18(19)14-20)33(31,32)26(2)16-21-22(24)4-3-5-23(21)25/h3-7,14H,8-13,15-16H2,1-2H3 NSTZLLFHPYOWMP-UHFFFAOYSA-N 50572708 CHEMBL4851155 Nuclear receptor ROR-gamma Mus musculus 220 ChEMBL 10.1016/j.ejmech.2021.113585 10.7270/Q2S75M5R 34118722 Ma, X; Sun, N; Li, X; Fu, W Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50572708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50572708&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 164617327 471062853 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51411653 CC(C)(O)C(=O)N[C@@H]1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 InChI=1S/C26H25F8NO4S/c1-22(2,37)21(36)35-20-11-12-23(40(38,39)17-7-5-16(27)6-8-17)18-10-4-15(13-14(18)3-9-19(20)23)24(28,25(29,30)31)26(32,33)34/h4-8,10,13,19-20,37H,3,9,11-12H2,1-2H3,(H,35,36)/t19-,20+,23+/m0/s1 JZUVTKBHDNIOHD-MIZPHKNDSA-N 414250 US10435369, Example 137 Nuclear receptor ROR-gamma Mus musculus 2.7 ChEMBL 10.1021/acs.jmedchem.0c01992 10.7270/Q2N87FJG 33591748 Yang, MG; Beaudoin-Bertrand, M; Xiao, Z; Marcoux, D; Weigelt, CA; Yip, S; Wu, DR; Ruzanov, M; Sack, JS; Wang, J; Yarde, M; Li, S; Shuster, DJ; Xie, JH; Sherry, T; Obermeier, MT; Fura, A; Stefanski, K; Cornelius, G; Khandelwal, P; Karmakar, A; Basha, M; Babu, V; Gupta, AK; Mathur, A; Salter-Cid, L; Denton, R; Zhao, Q; Dhar, TGM Bristol Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=414250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=414250&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search Z8G 7KQJ 134491220 433914336 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51411654 C[C@H]1C[C@@H](CC[C@H]1NN1CC[C@@]2([C@H]1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1)C(O)=O InChI=1S/C29H30F8N2O4S/c1-16-14-18(25(40)41)2-10-23(16)38-39-13-12-26(44(42,43)21-7-5-20(30)6-8-21)22-9-4-19(15-17(22)3-11-24(26)39)27(31,28(32,33)34)29(35,36)37/h4-9,15-16,18,23-24,38H,2-3,10-14H2,1H3,(H,40,41)/t16-,18+,23+,24+,26+/m0/s1 MUHYHLFUAPFACM-FIHPKFJVSA-N 50570328 CHEMBL4871326 Nuclear receptor ROR-gamma Mus musculus 11 ChEMBL 10.1021/acs.jmedchem.0c01992 10.7270/Q2N87FJG 33591748 Yang, MG; Beaudoin-Bertrand, M; Xiao, Z; Marcoux, D; Weigelt, CA; Yip, S; Wu, DR; Ruzanov, M; Sack, JS; Wang, J; Yarde, M; Li, S; Shuster, DJ; Xie, JH; Sherry, T; Obermeier, MT; Fura, A; Stefanski, K; Cornelius, G; Khandelwal, P; Karmakar, A; Basha, M; Babu, V; Gupta, AK; Mathur, A; Salter-Cid, L; Denton, R; Zhao, Q; Dhar, TGM Bristol Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570328&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 164619865 471060473 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51423192 CCS(=O)(=O)c1ccc(cc1)[C@@H](NC(C)=O)C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F InChI=1S/C21H20F6N2O5S/c1-3-35(33,34)16-10-4-13(5-11-16)17(28-12(2)30)18(31)29-15-8-6-14(7-9-15)19(32,20(22,23)24)21(25,26)27/h4-11,17,32H,3H2,1-2H3,(H,28,30)(H,29,31)/t17-/m1/s1 HJJYGXDBXQAVQG-QGZVFWFLSA-N 50502393 CHEMBL4562895 Nuclear receptor ROR-gamma Mus musculus 120 ChEMBL 10.1021/acs.jmedchem.1c01197 10.7270/Q22Z19BG 34464130 Narjes, F; Llinas, A; von Berg, S; Jirholt, J; Lever, S; Pehrson, R; Collins, M; Malmberg, A; Svanberg, P; Xue, Y; Olsson, RI; Malmberg, J; Hughes, G; Hossain, N; Grindebacke, H; Leffler, A; Krutrök, N; Bäck, E; Ramnegård, M; Lepistö, M; Thunberg, L; Aagaard, A; McPheat, J; Hansson, EL; Chen, R; Xiong, Y; Hansson, TG AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50502393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50502393&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search JUN 6R7J 138454290 440710978 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51423193 CC(=O)N1Cc2cc(ccc2[C@@H]1C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(C)(=O)=O InChI=1S/C21H18F6N2O5S/c1-11(30)29-10-12-9-15(35(2,33)34)7-8-16(12)17(29)18(31)28-14-5-3-13(4-6-14)19(32,20(22,23)24)21(25,26)27/h3-9,17,32H,10H2,1-2H3,(H,28,31)/t17-/m1/s1 QYYZXEPEVBXNNA-QGZVFWFLSA-N 50575029 CHEMBL4864604 Nuclear receptor ROR-gamma Mus musculus 84 ChEMBL 10.1021/acs.jmedchem.1c01197 10.7270/Q22Z19BG 34464130 Narjes, F; Llinas, A; von Berg, S; Jirholt, J; Lever, S; Pehrson, R; Collins, M; Malmberg, A; Svanberg, P; Xue, Y; Olsson, RI; Malmberg, J; Hughes, G; Hossain, N; Grindebacke, H; Leffler, A; Krutrök, N; Bäck, E; Ramnegård, M; Lepistö, M; Thunberg, L; Aagaard, A; McPheat, J; Hansson, EL; Chen, R; Xiong, Y; Hansson, TG AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50575029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50575029&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 129205086 471065174 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177 51452561 CCCN(CC1CCCCC1)Cc1ccc(NC(=O)Cc2ccc(cc2)S(C)(=O)=O)cc1Cl InChI=1S/C26H35ClN2O3S/c1-3-15-29(18-21-7-5-4-6-8-21)19-22-11-12-23(17-25(22)27)28-26(30)16-20-9-13-24(14-10-20)33(2,31)32/h9-14,17,21H,3-8,15-16,18-19H2,1-2H3,(H,28,30) UCJKFMKCLURICR-UHFFFAOYSA-N 50586451 CHEMBL5086647 Nuclear receptor ROR-gamma Mus musculus 37 ChEMBL 10.1016/j.ejmech.2021.113704 10.7270/Q22R3WKB 34303081 Qiu, R; Yu, M; Gong, J; Tian, J; Huang, Y; Wang, Y; Xie, Q Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50586451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006469&target=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50586451&enzyme=Nuclear+receptor+ROR-gamma&column=ki&startPg=0&Increment=50&submit=Search 166631325 476022538 1 MDRAPQRHHRTSRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQCNVAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQQQQQEQVAKTPPAGSRGADTLTYTLGLSDGQLPLGASPDLPEASACPPGLLRASGSGPPYSNTLAKTEVQGASCHLEYSPERGKAEGRDSIYSTDGQLTLGRCGLRFEETRHPELGEPEQGPDSHCIPSFCSAPEVPYASLTDIEYLVQNVCKSFRETCQLRLEDLLRQRTNLFSREEVTSYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIILLTAGAMEVVLVRMCRAYNANNHTVFFEGKYGGVELFRALGCSELISSIFDFSHFLSALCFSEDEIALYTALVLINANRPGLQEKRRVEHLQYNLELAFHHHLCKTHRQGLLAKLPPKGKLRSLCSQHVEKLQIFQHLHPIVVQAAFPPLYKELFSTDVESPEGLSK 5LWP,5NTI,5NTN,5NTW,5NU1,5X8Q,5X8W,5X8X,5YP6,6A22,6BN6,6CN6,6FZU,6G05,6G07,6IVX,6J1L,6J3N,6O98,6P9F,6SAL,6T4G,6T4I,6T4J,6T4K,6T4X,6T4Y,6T50,6TLM,6TLQ,6TLT,6U25,6VQF,6W9H,6W9I,6XAE,6XFV,7JH2,7JTM,7JYM,7KQJ,7KXD,7KXE,7KXF,7LUK,7NEC,7NP5,7NP6,7QP4,7XQE,8FAV,8FB1,8FB2 Nuclear receptor ROR-gamma RORG_MOUSE P51450 E9Q8I1 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177