BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50277578 COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1 InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26) UTAJHKSGYJSZBR-UHFFFAOYSA-N 50312105 2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide::CHEMBL1081188 Inward rectifier potassium channel 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2014.06.032 10.7270/Q2805487 25017033 Flaherty, DP; Simpson, DS; Miller, M; Maki, BE; Zou, B; Shi, J; Wu, M; McManus, OB; Aubé, J; Li, M; Golden, JE University of Kansas Specialized Chemistry Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312105&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 46785920 104146466 CHEMBL1081188 ZINC10773901 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50277579 Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(Cl)c2)c1 InChI=1S/C21H17ClN2O2/c1-14-5-2-6-15(11-14)20(25)23-18-9-4-10-19(13-18)24-21(26)16-7-3-8-17(22)12-16/h2-13H,1H3,(H,23,25)(H,24,26) KZXMFJORGLUXJN-UHFFFAOYSA-N 50312125 3-chloro-N-(3-(3-methylbenzamido)phenyl)benzamide::CHEMBL1086899 Inward rectifier potassium channel 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2014.06.032 10.7270/Q2805487 25017033 Flaherty, DP; Simpson, DS; Miller, M; Maki, BE; Zou, B; Shi, J; Wu, M; McManus, OB; Aubé, J; Li, M; Golden, JE University of Kansas Specialized Chemistry Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50312125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50312125&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 46880148 104146486 CHEMBL1086899 ZINC49052313 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50277580 Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1 InChI=1S/C22H17F3N2O2/c1-14-6-4-7-15(12-14)20(28)26-16-8-5-9-17(13-16)27-21(29)18-10-2-3-11-19(18)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29) ICGUNWJVOUCAAB-UHFFFAOYSA-N 50050530 CHEMBL3188857 Inward rectifier potassium channel 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2014.06.032 10.7270/Q2805487 25017033 Flaherty, DP; Simpson, DS; Miller, M; Maki, BE; Zou, B; Shi, J; Wu, M; McManus, OB; Aubé, J; Li, M; Golden, JE University of Kansas Specialized Chemistry Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50050530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50050530&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 49852195 103947691 CHEMBL3188857 ZINC04654627 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50277581 Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1 InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29) ISMGZXXGNKTCRO-UHFFFAOYSA-N 50050534 CHEMBL3183773 Inward rectifier potassium channel 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2014.06.032 10.7270/Q2805487 25017033 Flaherty, DP; Simpson, DS; Miller, M; Maki, BE; Zou, B; Shi, J; Wu, M; McManus, OB; Aubé, J; Li, M; Golden, JE University of Kansas Specialized Chemistry Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50050534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50050534&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 49852192 313069272 CHEMBL3183773 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50277582 Cc1cccc(c1)C(=O)Nc1cccc(NC(=O)c2ccncc2)c1 InChI=1S/C20H17N3O2/c1-14-4-2-5-16(12-14)20(25)23-18-7-3-6-17(13-18)22-19(24)15-8-10-21-11-9-15/h2-13H,1H3,(H,22,24)(H,23,25) KCZVRYSHVOQAAB-UHFFFAOYSA-N 50050539 CHEMBL3187891 Inward rectifier potassium channel 2 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2014.06.032 10.7270/Q2805487 25017033 Flaherty, DP; Simpson, DS; Miller, M; Maki, BE; Zou, B; Shi, J; Wu, M; McManus, OB; Aubé, J; Li, M; Golden, JE University of Kansas Specialized Chemistry Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50050539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50050539&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 49852191 313069277 CHEMBL3187891 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50405383 COc1cc(ncc1C#N)[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)CC1 InChI=1S/C24H28N4O5/c1-15-17(3-4-18-19(15)14-33-24(18)31)21(29)12-27-5-7-28(8-6-27)13-22(30)20-9-23(32-2)16(10-25)11-26-20/h3-4,9,11,21-22,29-30H,5-8,12-14H2,1-2H3/t21-,22-/m0/s1 QZUKGDYPSXQBSQ-VXKWHMMOSA-N 155928 US9018211, 52 Inward rectifier potassium channel 2 Homo sapiens >50000 ChEMBL 10.1021/ml500440u 10.7270/Q27H1MCQ 26191360 Walsh, SP; Shahripour, A; Tang, H; Teumelsan, N; Frie, J; Zhu, Y; Priest, BT; Swensen, AM; Liu, J; Margulis, M; Visconti, R; Weinglass, A; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Alonso-Galicia, M; Zhou, X; Pai, LY; Corona, A; Hampton, C; Hernandez, M; Bentley, R; Chen, J; Shah, K; Metzger, J; Forrest, M; Owens, K; Tong, V; Ha, S; Roy, S; Kaczorowski, GJ; Yang, L; Parmee, E; Garcia, ML; Sullivan, K; Pasternak, A Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=155928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=155928&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 59568656 253681490 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50490316 Cc1c2COC(=O)c2ccc1CCN1CCN(CC1)C(=O)Cc1ccc(nc1)-n1cnnn1 InChI=1S/C23H25N7O3/c1-16-18(3-4-19-20(16)14-33-23(19)32)6-7-28-8-10-29(11-9-28)22(31)12-17-2-5-21(24-13-17)30-15-25-26-27-30/h2-5,13,15H,6-12,14H2,1H3 PDBQDSXSCZPLNA-UHFFFAOYSA-N 162872 US9056859, 72 Inward rectifier potassium channel 2 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2016.03.035 10.7270/Q2668G3Q 27017115 Walsh, SP; Shahripour, A; Tang, H; de Jesus, RK; Teumelsan, N; Zhu, Y; Frie, J; Priest, BT; Swensen, AM; Alonso-Galicia, M; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Zhou, X; Pai, LY; Hampton, C; Hernandez, M; Owens, K; Ehrhart, J; Roy, S; Kaczorowski, GJ; Yang, L; Garcia, ML; Pasternak, A Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=162872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=162872&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 57331668 310304809 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50954709 [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+]([O-])=O)CC2)cc1 InChI=1S/C20H24N4O4/c25-23(26)19-5-1-17(2-6-19)9-11-21-13-15-22(16-14-21)12-10-18-3-7-20(8-4-18)24(27)28/h1-8H,9-16H2 GKZBQPSXHBJOPU-UHFFFAOYSA-N 50391770 CHEMBL2146755::US9073882, 1 Inward rectifier potassium channel 2 Homo sapiens >100000 ChEMBL 10.1021/ml3000066 10.7270/Q2MK6DZV 24900480 Tang, H; Walsh, SP; Yan, Y; de Jesus, RK; Shahripour, A; Teumelsan, N; Zhu, Y; Ha, S; Owens, KA; Thomas-Fowlkes, BS; Felix, JP; Liu, J; Kohler, M; Priest, BT; Bailey, T; Brochu, R; Alonso-Galicia, M; Kaczorowski, GJ; Roy, S; Yang, L; Mills, SG; Garcia, ML; Pasternak, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391770&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 52337837 163340794 CHEMBL2146755 ZINC51180806 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50954716 [O-][N+](=O)c1ccc(CCN2CCNCC2)cc1 InChI=1S/C12H17N3O2/c16-15(17)12-3-1-11(2-4-12)5-8-14-9-6-13-7-10-14/h1-4,13H,5-10H2 LDHDLZVIOVDTCH-UHFFFAOYSA-N 50391771 CHEMBL2146754 Inward rectifier potassium channel 2 Homo sapiens >100000 ChEMBL 10.1021/ml3000066 10.7270/Q2MK6DZV 24900480 Tang, H; Walsh, SP; Yan, Y; de Jesus, RK; Shahripour, A; Teumelsan, N; Zhu, Y; Ha, S; Owens, KA; Thomas-Fowlkes, BS; Felix, JP; Liu, J; Kohler, M; Priest, BT; Bailey, T; Brochu, R; Alonso-Galicia, M; Kaczorowski, GJ; Roy, S; Yang, L; Mills, SG; Garcia, ML; Pasternak, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391771&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 14985965 163340795 CHEMBL2146754 ZINC19726918 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 51081942 O=C(Cc1ccc(cc1)-n1cnnn1)N1CCN(CCc2ccc3C(=O)OCc3c2)CC1 InChI=1S/C23H24N6O3/c30-22(14-17-1-4-20(5-2-17)29-16-24-25-26-29)28-11-9-27(10-12-28)8-7-18-3-6-21-19(13-18)15-32-23(21)31/h1-6,13,16H,7-12,14-15H2 LKLRNYYBQWYHND-UHFFFAOYSA-N 50442600 CHEMBL2441437::US9056859, 1 Inward rectifier potassium channel 2 Homo sapiens >50000 ChEMBL 10.1016/j.bmcl.2013.08.104 10.7270/Q28K7BHG 24075732 Tang, H; de Jesus, RK; Walsh, SP; Zhu, Y; Yan, Y; Priest, BT; Swensen, AM; Alonso-Galicia, M; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Zhou, X; Pai, LY; Hampton, C; Hernandez, M; Owens, K; Roy, S; Kaczorowski, GJ; Yang, L; Garcia, ML; Pasternak, A Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50442600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50442600&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 57331209 175454917 CHEMBL2441437 ZINC96286275 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50532965 Cc1c(ccc(F)c1C#N)[C@@H]1CN2CCN(C[C@H]2CO1)C(=O)Cc1ccc(cn1)-n1cnnn1 InChI=1S/C23H23FN8O2/c1-15-19(4-5-21(24)20(15)9-25)22-12-30-6-7-31(11-18(30)13-34-22)23(33)8-16-2-3-17(10-26-16)32-14-27-28-29-32/h2-5,10,14,18,22H,6-8,11-13H2,1H3/t18-,22-/m0/s1 XHSSYBXTQWHQSD-AVRDEDQJSA-N 50204281 CHEMBL3933749 Inward rectifier potassium channel 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2016.10.064 10.7270/Q2F191PS 27839686 Zhu, Y; de Jesus, RK; Tang, H; Walsh, SP; Jiang, J; Gu, X; Teumelsan, N; Shahripour, A; Pio, B; Ding, FX; Ha, S; Priest, BT; Swensen, AM; Alonso-Galicia, M; Felix, JP; Brochu, RM; Bailey, T; Thomas-Fowlkes, B; Zhou, X; Pai, LY; Hampton, C; Hernandez, M; Owens, K; Ehrhart, J; Roy, S; Kaczorowski, GJ; Yang, L; Parmee, ER; Sullivan, K; Garcia, ML; Pasternak, A Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50204281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50204281&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 71603917 375980441 CHEMBL3933749 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50809218 Cc1cc(Oc2cncnc2)cc(n1)C(=O)Nc1ccc(F)cn1 InChI=1S/C16H12FN5O2/c1-10-4-12(24-13-7-18-9-19-8-13)5-14(21-10)16(23)22-15-3-2-11(17)6-20-15/h2-9H,1H3,(H,20,22,23) RBAHIIPVJVMACF-UHFFFAOYSA-N 50257064 CHEMBL2386850 Inward rectifier potassium channel 2 Homo sapiens >100000 ChEMBL 10.1021/acs.jmedchem.7b00410 10.7270/Q2JH3PM7 28530802 Felts, AS; Rodriguez, AL; Blobaum, AL; Morrison, RD; Bates, BS; Thompson Gray, A; Rook, JM; Tantawy, MN; Byers, FW; Chang, S; Venable, DF; Luscombe, VB; Tamagnan, GD; Niswender, CM; Daniels, JS; Jones, CK; Conn, PJ; Lindsley, CW; Emmitte, KA Vanderbilt University Institute of Imaging Science http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50257064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50257064&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 60168069 402360958 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50815925 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc(cn1)C#N InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1 HARRKNSQXBRBGZ-GVKWWOCJSA-N 50258216 CHEMBL4105630 Inward rectifier potassium channel 2 Homo sapiens >30000 ChEMBL 10.1021/acs.jmedchem.7b00846 10.7270/Q2ZK5K4W 28753313 Martinez Botella, G; Salituro, FG; Harrison, BL; Beresis, RT; Bai, Z; Blanco, MJ; Belfort, GM; Dai, J; Loya, CM; Ackley, MA; Althaus, AL; Grossman, SJ; Hoffmann, E; Doherty, JJ; Robichaud, AJ Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258216&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 86294073 402361454 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 50780044 Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC2(CCN(C2=O)c2ccc(=O)n(C)n2)CC1 InChI=1S/C24H28N4O5/c1-15-16(3-4-17-18(15)14-33-22(17)31)19(29)13-27-10-7-24(8-11-27)9-12-28(23(24)32)20-5-6-21(30)26(2)25-20/h3-6,19,29H,7-14H2,1-2H3/t19-/m0/s1 AEQJLXICIKRMCT-IBGZPJMESA-N 50249183 CHEMBL4069245 Inward rectifier potassium channel 2 Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2017.03.086 10.7270/Q2BV7K1G 28431879 Dong, S; VanGelder, K; Shi, ZC; Yu, Y; Wu, Z; Ferguson, R; Guo, ZZ; Tang, H; Frie, J; Fu, Q; Gu, X; Priest, BT; Thomas-Fowlkes, B; Weinglass, A; Margulis, M; Liu, J; Pai, LY; Hampton, C; Haimbach, RE; Owens, K; Tong, V; Xu, S; Hu, M; Zingaro, GJ; Morissette, P; Ehrhart, J; Roy, S; Sullivan, K; Pasternak, A Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50249183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50249183&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 121313969 104103550 ZINC40913787 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 51373193 FC(F)(F)c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@H]1CNCCO1 InChI=1S/C16H16F3N7O/c17-16(18,19)12-8-25-14(26-15-9-22-10(4-20)5-24-15)3-13(12)23-7-11-6-21-1-2-27-11/h3,5,8-9,11,21H,1-2,6-7H2,(H2,23,24,25,26)/t11-/m1/s1 YBYYWUUUGCNAHQ-LLVKDONJSA-N 328993 5-[[4-[[(2R)-morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile::US9663503, Compound 1 Inward rectifier potassium channel 2 Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.5b01938 10.7270/Q2MG7T5V 27167172 Osborne, JD; Matthews, TP; McHardy, T; Proisy, N; Cheung, KM; Lainchbury, M; Brown, N; Walton, MI; Eve, PD; Boxall, KJ; Hayes, A; Henley, AT; Valenti, MR; De Haven Brandon, AK; Box, G; Jamin, Y; Robinson, SP; Westwood, IM; van Montfort, RL; Leonard, PM; Lamers, MB; Reader, JC; Aherne, GW; Raynaud, FI; Eccles, SA; Garrett, MD; Collins, I Sareum Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=328993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=328993&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 72165232 384573914 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 1271110 FC(F)(F)c1nn(CC(=O)N2CCCc3ccccc23)c2CCCCc12 InChI=1S/C19H20F3N3O/c20-19(21,22)18-14-8-2-4-10-16(14)25(23-18)12-17(26)24-11-5-7-13-6-1-3-9-15(13)24/h1,3,6,9H,2,4-5,7-8,10-12H2 DLAGRCZUELSZFG-UHFFFAOYSA-N 600745 US11632953, Compound 1::US11632953, Compound VU041 Inward rectifier potassium channel 2 Homo sapiens 12700 US Patent 10.7270/Q2GT5S4F US11632953 Swale, DR; Foil, LD Board of Supervisors of Louisiana State University and Agricultural and Mechanical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=600745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=600745&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 1129704 482091860 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 1271115 FC(F)(F)c1nn(CC(=O)N2CCCc3ccccc23)c2CCCCc12 InChI=1S/C19H20F3N3O/c20-19(21,22)18-14-8-2-4-10-16(14)25(23-18)12-17(26)24-11-5-7-13-6-1-3-9-15(13)24/h1,3,6,9H,2,4-5,7-8,10-12H2 DLAGRCZUELSZFG-UHFFFAOYSA-N 600745 US11632953, Compound 1::US11632953, Compound VU041 Inward rectifier potassium channel 2 Homo sapiens 11300 US Patent 10.7270/Q2GT5S4F US11632953 Swale, DR; Foil, LD Board of Supervisors of Louisiana State University and Agricultural and Mechanical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=600745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=600745&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 1129704 482091860 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 1271117 O=C(Cn1ccc2c1CCCC2=O)N1CCCc2ccccc12 InChI=1S/C19H20N2O2/c22-18-9-3-8-17-15(18)10-12-20(17)13-19(23)21-11-4-6-14-5-1-2-7-16(14)21/h1-2,5,7,10,12H,3-4,6,8-9,11,13H2 QXQNOZDLYAVHPH-UHFFFAOYSA-N 600747 US11632953, Compound 4::VU0650729 Inward rectifier potassium channel 2 Homo sapiens >30000 US Patent 10.7270/Q2GT5S4F US11632953 Swale, DR; Foil, LD Board of Supervisors of Louisiana State University and Agricultural and Mechanical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=600747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=600747&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 168300266 482091861 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 1271119 O=C(Cn1ncc2COCCc12)N1CCCc2ccccc12 InChI=1S/C17H19N3O2/c21-17(11-20-16-7-9-22-12-14(16)10-18-20)19-8-3-5-13-4-1-2-6-15(13)19/h1-2,4,6,10H,3,5,7-9,11-12H2 NCZCAXHQNROXNW-UHFFFAOYSA-N 600748 US11632953, Compound 5::VU0650730 Inward rectifier potassium channel 2 Homo sapiens >30000 US Patent 10.7270/Q2GT5S4F US11632953 Swale, DR; Foil, LD Board of Supervisors of Louisiana State University and Agricultural and Mechanical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=600748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=600748&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 165871587 482091862 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 1271124 FC(F)(F)c1nn(CC(=O)N2CCCC3CCCCC23)c2CCCCc12 InChI=1S/C19H26F3N3O/c20-19(21,22)18-14-8-2-4-10-16(14)25(23-18)12-17(26)24-11-5-7-13-6-1-3-9-15(13)24/h13,15H,1-12H2 NCJGQXUZXUQYQD-UHFFFAOYSA-N 600751 US11632953, Compound 9::VU0652954 Inward rectifier potassium channel 2 Homo sapiens >30000 US Patent 10.7270/Q2GT5S4F US11632953 Swale, DR; Foil, LD Board of Supervisors of Louisiana State University and Agricultural and Mechanical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=600751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=600751&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 168300268 482091865 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 1271126 FC(F)(F)c1nn(CC(=O)N2CCCC(C2)c2ccccc2)c2CCCCc12 InChI=1S/C21H24F3N3O/c22-21(23,24)20-17-10-4-5-11-18(17)27(25-20)14-19(28)26-12-6-9-16(13-26)15-7-2-1-3-8-15/h1-3,7-8,16H,4-6,9-14H2 YWNAILVCKKYXBX-UHFFFAOYSA-N 600754 US11632953, Compound 12::VU0652942 Inward rectifier potassium channel 2 Homo sapiens >30000 US Patent 10.7270/Q2GT5S4F US11632953 Swale, DR; Foil, LD Board of Supervisors of Louisiana State University and Agricultural and Mechanical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=600754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=600754&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 168300271 482091868 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049 1271128 CC1CC(C)CN(C1)C(=O)Cn1nc(c2CCCCc12)C(F)(F)F InChI=1S/C17H24F3N3O/c1-11-7-12(2)9-22(8-11)15(24)10-23-14-6-4-3-5-13(14)16(21-23)17(18,19)20/h11-12H,3-10H2,1-2H3 YNNQAMRGLWHWJN-UHFFFAOYSA-N 600755 US11632953, Compound 13::VU0652943 Inward rectifier potassium channel 2 Homo sapiens >30000 US Patent 10.7270/Q2GT5S4F US11632953 Swale, DR; Foil, LD Board of Supervisors of Louisiana State University and Agricultural and Mechanical College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=600755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006131&target=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=600755&enzyme=Inward+rectifier+potassium+channel+2&column=ki&startPg=0&Increment=50&submit=Search 168300272 482091869 1 MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI 2XKY,7ZDZ Inward rectifier potassium channel 2 KCNJ2_HUMAN P63252 O15110 P48049