BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 455090 Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1 WKKAVTNXNVPCCN-HSZRJFAPSA-N 65493 eIF4A3 inhibitor, 2 Eukaryotic initiation factor 4A-I Homo sapiens >1.00e+5 Curated from the literature by BindingDB 10.1021/acschembio.7b00041 10.7270/Q2T151TG 28440616 aid1794856 Iwatani-Yoshihara, M; Ito, M; Ishibashi, Y; Oki, H; Tanaka, T; Morishita, D; Ito, T; Kimura, H; Imaeda, Y; Aparicio, S; Nakanishi, A; Kawamoto, T BC Cancer Agency http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65493&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 131953885 350083116 ZINC25390470 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50946118 CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC InChI=1S/C28H29NO8/c1-33-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(31)29-36-4)25(30)27(28,32)24-20(35-3)14-19(34-2)15-21(24)37-28/h5-15,22-23,25,30,32H,1-4H3,(H,29,31)/t22-,23-,25-,27+,28+/m1/s1 KLSIFOJPWJBRFH-GWNOIRNCSA-N 50388144 CHEMBL2058177 Eukaryotic initiation factor 4A-I Homo sapiens 20 ChEMBL 10.1021/jm201263k 10.7270/Q2MS3TTZ 22128783 Rodrigo, CM; Cencic, R; Roche, SP; Pelletier, J; Porco, JA Boston University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50388144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50388144&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 56946209 160867227 CHEMBL2058177 ZINC84689886 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50946119 CONC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC InChI=1S/C28H29NO8/c1-33-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(31)29-36-4)25(30)27(28,32)24-20(35-3)14-19(34-2)15-21(24)37-28/h5-15,22-23,25,30,32H,1-4H3,(H,29,31)/t22-,23-,25-,27+,28+/m1/s1 KLSIFOJPWJBRFH-GWNOIRNCSA-N 50388144 CHEMBL2058177 Eukaryotic initiation factor 4A-I Homo sapiens 0.5 ChEMBL 10.1021/jm201263k 10.7270/Q2MS3TTZ 22128783 Rodrigo, CM; Cencic, R; Roche, SP; Pelletier, J; Porco, JA Boston University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50388144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50388144&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 56946209 160867227 CHEMBL2058177 ZINC84689886 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968980 CO[C@@H]1OC[C@H](CO)O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C33H36O12/c1-38-20-12-10-19(11-13-20)33-26(18-8-6-5-7-9-18)25(29(36)40-3)28(35)32(33,37)27-23(39-2)14-21(15-24(27)45-33)43-31-30(41-4)42-17-22(16-34)44-31/h5-15,22,25-26,28,30-31,34-35,37H,16-17H2,1-4H3/t22-,25+,26+,28+,30+,31+,32-,33-/m0/s1 XCYFZWJSUGHZTC-RSVVDNQOSA-N 50397412 CHEMBL2170718 Eukaryotic initiation factor 4A-I Homo sapiens 3 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397412&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456988 163346436 CHEMBL2170718 ZINC95553075 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968981 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1COC[C@@H](O1)[C@H](O)CO)cc3OC InChI=1S/C33H36O12/c1-39-20-11-9-19(10-12-20)33-28(18-7-5-4-6-8-18)27(31(37)41-3)30(36)32(33,38)29-23(40-2)13-21(14-24(29)45-33)43-26-17-42-16-25(44-26)22(35)15-34/h4-14,22,25-28,30,34-36,38H,15-17H2,1-3H3/t22-,25-,26-,27-,28-,30-,32+,33+/m1/s1 VLLCANNFGBMAID-BLVHDQTMSA-N 50397413 CHEMBL2170725 Eukaryotic initiation factor 4A-I Homo sapiens 3 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397413&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456989 163346437 CHEMBL2170725 ZINC95557022 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968982 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(cc1)C#N)cc(OC)cc3OC InChI=1S/C28H25NO7/c1-33-19-13-20(34-2)24-21(14-19)36-28(18-11-9-16(15-29)10-12-18)23(17-7-5-4-6-8-17)22(26(31)35-3)25(30)27(24,28)32/h4-14,22-23,25,30,32H,1-3H3/t22-,23-,25-,27+,28+/m1/s1 MZIWUVAPRYAGMM-GWNOIRNCSA-N 50397414 CHEMBL2170559 Eukaryotic initiation factor 4A-I Homo sapiens 2 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397414&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71458846 163346438 CHEMBL2170559 ZINC95554552 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968983 COc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)N(C)C)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C29H28N2O6/c1-31(2)27(33)23-24(18-8-6-5-7-9-18)29(19-12-10-17(16-30)11-13-19)28(34,26(23)32)25-21(36-4)14-20(35-3)15-22(25)37-29/h5-15,23-24,26,32,34H,1-4H3/t23-,24-,26-,28+,29+/m1/s1 CKHVREJQHBANOJ-IDAMAFBJSA-N 50397415 CHEMBL2170703 Eukaryotic initiation factor 4A-I Homo sapiens 1.2 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397415&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455198 163346439 CHEMBL2170703 ZINC95556296 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968984 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(C)=O InChI=1S/C29H28O8/c1-16(30)18-14-21(35-3)25-22(15-18)37-29(19-10-12-20(34-2)13-11-19)24(17-8-6-5-7-9-17)23(27(32)36-4)26(31)28(25,29)33/h5-15,23-24,26,31,33H,1-4H3/t23-,24-,26-,28+,29+/m1/s1 JMTJQGAMQVTDMS-IDAMAFBJSA-N 50397416 CHEMBL2170555 Eukaryotic initiation factor 4A-I Homo sapiens 1 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397416&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71451648 163346440 CHEMBL2170555 ZINC95555821 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968985 CO[C@@H]1OC[C@H](CCO)O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31+,32-,33-,34-/m0/s1 FHFGXZOISSRNIH-VVGMJCCQSA-N 50397417 CHEMBL2170714 Eukaryotic initiation factor 4A-I Homo sapiens 1 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397417&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455199 163346441 CHEMBL2170714 ZINC95557391 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968986 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C#N InChI=1S/C28H25NO7/c1-33-19-11-9-18(10-12-19)28-23(17-7-5-4-6-8-17)22(26(31)35-3)25(30)27(28,32)24-20(34-2)13-16(15-29)14-21(24)36-28/h4-14,22-23,25,30,32H,1-3H3/t22-,23-,25-,27+,28+/m1/s1 WRACOSLBAUYQOQ-GWNOIRNCSA-N 50397418 CHEMBL2170556 Eukaryotic initiation factor 4A-I Homo sapiens 0.9 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397418&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456983 163346442 CHEMBL2170556 ZINC95555137 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968987 COc1ccc(cc1)[C@@]12Oc3cc(cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C)C#N InChI=1S/C29H28N2O6/c1-31(2)27(33)23-24(18-8-6-5-7-9-18)29(19-10-12-20(35-3)13-11-19)28(34,26(23)32)25-21(36-4)14-17(16-30)15-22(25)37-29/h5-15,23-24,26,32,34H,1-4H3/t23-,24-,26-,28+,29+/m1/s1 PYRHQQZNFDRIGQ-IDAMAFBJSA-N 50397419 CHEMBL2170562 Eukaryotic initiation factor 4A-I Homo sapiens 0.8 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397419&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71453480 163346443 CHEMBL2170562 ZINC95554848 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968988 CO[C@@H]1OC[C@@H](O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1)[C@H](O)CO InChI=1S/C34H38O13/c1-40-20-12-10-19(11-13-20)34-27(18-8-6-5-7-9-18)26(30(38)42-3)29(37)33(34,39)28-23(41-2)14-21(15-24(28)47-34)45-32-31(43-4)44-17-25(46-32)22(36)16-35/h5-15,22,25-27,29,31-32,35-37,39H,16-17H2,1-4H3/t22-,25-,26-,27-,29-,31-,32-,33+,34+/m1/s1 GVKXFVCXBFGBCD-QKDMMWSPSA-N 50335583 CHEMBL555196::silvestrol Eukaryotic initiation factor 4A-I Homo sapiens 0.8 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335583&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 11787114 125085685 66484 CHEMBL555196 ZINC95099283 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968989 COc1ccc(cc1)[C@@]12Oc3cc(Cl)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C InChI=1S/C28H28ClNO6/c1-30(2)26(32)22-23(16-8-6-5-7-9-16)28(17-10-12-19(34-3)13-11-17)27(33,25(22)31)24-20(35-4)14-18(29)15-21(24)36-28/h5-15,22-23,25,31,33H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 QGAOOBALZRBQLX-GWNOIRNCSA-N 50397420 CHEMBL2170563 Eukaryotic initiation factor 4A-I Homo sapiens 0.6 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397420&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455193 163346444 CHEMBL2170563 ZINC95557348 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968990 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(=O)OC InChI=1S/C29H28O9/c1-34-19-12-10-18(11-13-19)29-23(16-8-6-5-7-9-16)22(27(32)37-4)25(30)28(29,33)24-20(35-2)14-17(26(31)36-3)15-21(24)38-29/h5-15,22-23,25,30,33H,1-4H3/t22-,23-,25-,28+,29+/m1/s1 PFGXGRUGXUDDMN-VBIJGHLJSA-N 50397421 CHEMBL2170713 Eukaryotic initiation factor 4A-I Homo sapiens 0.2 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397421&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71458852 163346445 CHEMBL2170713 ZINC95556201 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968991 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1CNC[C@@H](CO)O1)cc3OC InChI=1S/C32H35NO10/c1-38-20-11-9-19(10-12-20)32-27(18-7-5-4-6-8-18)26(30(36)40-3)29(35)31(32,37)28-23(39-2)13-21(14-24(28)43-32)41-25-16-33-15-22(17-34)42-25/h4-14,22,25-27,29,33-35,37H,15-17H2,1-3H3/t22-,25+,26+,27+,29+,31-,32-/m0/s1 XTICBJOICYVFPG-ZYULIPTCSA-N 50397422 CHEMBL2170704 Eukaryotic initiation factor 4A-I Homo sapiens 80 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397422&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456985 163346446 CHEMBL2170704 ZINC95554113 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968992 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(Cl)cc3OC InChI=1S/C27H25ClO7/c1-32-18-11-9-16(10-12-18)27-22(15-7-5-4-6-8-15)21(25(30)34-3)24(29)26(27,31)23-19(33-2)13-17(28)14-20(23)35-27/h4-14,21-22,24,29,31H,1-3H3/t21-,22-,24-,26+,27+/m1/s1 FAWAZAWGOJUXDV-PXIJUOARSA-N 50397423 CHEMBL2170557 Eukaryotic initiation factor 4A-I Homo sapiens 70 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397423&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462367 163346447 CHEMBL2170557 ZINC95556887 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968993 CO[C@@H]1OC[C@H](CO)O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C33H36O12/c1-38-20-12-10-19(11-13-20)33-26(18-8-6-5-7-9-18)25(29(36)40-3)28(35)32(33,37)27-23(39-2)14-21(15-24(27)45-33)43-31-30(41-4)42-17-22(16-34)44-31/h5-15,22,25-26,28,30-31,34-35,37H,16-17H2,1-4H3/t22-,25+,26+,28+,30+,31+,32-,33-/m0/s1 XCYFZWJSUGHZTC-RSVVDNQOSA-N 50397412 CHEMBL2170718 Eukaryotic initiation factor 4A-I Homo sapiens 60 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397412&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456988 163346436 CHEMBL2170718 ZINC95553075 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968994 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1CCC[C@@H](CO)O1)cc3OC InChI=1S/C33H36O10/c1-38-21-14-12-20(13-15-21)33-28(19-8-5-4-6-9-19)27(31(36)40-3)30(35)32(33,37)29-24(39-2)16-23(17-25(29)43-33)42-26-11-7-10-22(18-34)41-26/h4-6,8-9,12-17,22,26-28,30,34-35,37H,7,10-11,18H2,1-3H3/t22-,26-,27+,28+,30+,32-,33-/m0/s1 QJTDBNUOGMBVKE-XIDCDTCBSA-N 50397424 CHEMBL2170723 Eukaryotic initiation factor 4A-I Homo sapiens 50 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397424&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462377 163346448 CHEMBL2170723 ZINC95556205 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968995 COc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)N(C)C)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C29H28N2O6/c1-31(2)27(33)23-24(18-8-6-5-7-9-18)29(19-12-10-17(16-30)11-13-19)28(34,26(23)32)25-21(36-4)14-20(35-3)15-22(25)37-29/h5-15,23-24,26,32,34H,1-4H3/t23-,24-,26-,28+,29+/m1/s1 CKHVREJQHBANOJ-IDAMAFBJSA-N 50397415 CHEMBL2170703 Eukaryotic initiation factor 4A-I Homo sapiens 40 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397415&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455198 163346439 CHEMBL2170703 ZINC95556296 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968996 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1COC[C@H](CO)O1)cc3OC InChI=1S/C32H34O11/c1-37-20-11-9-19(10-12-20)32-27(18-7-5-4-6-8-18)26(30(35)39-3)29(34)31(32,36)28-23(38-2)13-21(14-24(28)43-32)41-25-17-40-16-22(15-33)42-25/h4-14,22,25-27,29,33-34,36H,15-17H2,1-3H3/t22-,25+,26+,27+,29+,31-,32-/m0/s1 OVOVDBXSEFZMNO-ZYULIPTCSA-N 50397425 CHEMBL2170722 Eukaryotic initiation factor 4A-I Homo sapiens 40 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397425&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455200 163346449 CHEMBL2170722 ZINC95554592 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968997 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(N)cc3OC InChI=1S/C27H27NO7/c1-32-18-11-9-16(10-12-18)27-22(15-7-5-4-6-8-15)21(25(30)34-3)24(29)26(27,31)23-19(33-2)13-17(28)14-20(23)35-27/h4-14,21-22,24,29,31H,28H2,1-3H3/t21-,22-,24-,26+,27+/m1/s1 LDWPQOSSUCBSKV-PXIJUOARSA-N 50397426 CHEMBL2170708 Eukaryotic initiation factor 4A-I Homo sapiens 40 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397426&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71460660 163346450 CHEMBL2170708 ZINC95555227 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968998 COc1ccc(cc1)[C@@]12Oc3cc(cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C)C#N InChI=1S/C29H28N2O6/c1-31(2)27(33)23-24(18-8-6-5-7-9-18)29(19-10-12-20(35-3)13-11-19)28(34,26(23)32)25-21(36-4)14-17(16-30)15-22(25)37-29/h5-15,23-24,26,32,34H,1-4H3/t23-,24-,26-,28+,29+/m1/s1 PYRHQQZNFDRIGQ-IDAMAFBJSA-N 50397419 CHEMBL2170562 Eukaryotic initiation factor 4A-I Homo sapiens 35 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397419&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71453480 163346443 CHEMBL2170562 ZINC95554848 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50968999 CNC(=O)c1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C29H29NO8/c1-30-26(32)17-14-20(36-3)24-21(15-17)38-29(18-10-12-19(35-2)13-11-18)23(16-8-6-5-7-9-16)22(27(33)37-4)25(31)28(24,29)34/h5-15,22-23,25,31,34H,1-4H3,(H,30,32)/t22-,23-,25-,28+,29+/m1/s1 QGBWLAVVBBEGCQ-VBIJGHLJSA-N 50397427 CHEMBL2170553 Eukaryotic initiation factor 4A-I Homo sapiens 35 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397427&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456982 163346451 CHEMBL2170553 ZINC95553407 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969000 CO[C@@H]1OC[C@H](CO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C33H36O12/c1-38-20-12-10-19(11-13-20)33-26(18-8-6-5-7-9-18)25(29(36)40-3)28(35)32(33,37)27-23(39-2)14-21(15-24(27)45-33)43-31-30(41-4)42-17-22(16-34)44-31/h5-15,22,25-26,28,30-31,34-35,37H,16-17H2,1-4H3/t22-,25+,26+,28+,30+,31-,32-,33-/m0/s1 XCYFZWJSUGHZTC-MQQGTTPASA-N 50397428 CHEMBL2170719 Eukaryotic initiation factor 4A-I Homo sapiens 35 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397428&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462376 163346452 CHEMBL2170719 ZINC95555545 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969001 CO[C@H]1OC[C@H](CCO)O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31-,32-,33-,34-/m0/s1 FHFGXZOISSRNIH-SEQXORCOSA-N 50397429 CHEMBL2170716 Eukaryotic initiation factor 4A-I Homo sapiens 35 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397429&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71458853 163346453 CHEMBL2170716 ZINC95556952 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969002 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(C)=O InChI=1S/C29H28O8/c1-16(30)18-14-21(35-3)25-22(15-18)37-29(19-10-12-20(34-2)13-11-19)24(17-8-6-5-7-9-17)23(27(32)36-4)26(31)28(25,29)33/h5-15,23-24,26,31,33H,1-4H3/t23-,24-,26-,28+,29+/m1/s1 JMTJQGAMQVTDMS-IDAMAFBJSA-N 50397416 CHEMBL2170555 Eukaryotic initiation factor 4A-I Homo sapiens 30 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397416&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71451648 163346440 CHEMBL2170555 ZINC95555821 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969003 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(N)=O InChI=1S/C28H27NO8/c1-34-18-11-9-17(10-12-18)28-22(15-7-5-4-6-8-15)21(26(32)36-3)24(30)27(28,33)23-19(35-2)13-16(25(29)31)14-20(23)37-28/h4-14,21-22,24,30,33H,1-3H3,(H2,29,31)/t21-,22-,24-,27+,28+/m1/s1 NDSAJVZNWSEAEP-BIKHGDPZSA-N 50397430 CHEMBL2169895 Eukaryotic initiation factor 4A-I Homo sapiens 29 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397430&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71460662 163346454 CHEMBL2169895 ZINC95554173 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969004 COc1ccc(cc1)[C@@]12Oc3cc(O[C@H]4COC[C@H](CO)O4)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C InChI=1S/C33H37NO10/c1-34(2)31(37)27-28(19-8-6-5-7-9-19)33(20-10-12-21(39-3)13-11-20)32(38,30(27)36)29-24(40-4)14-22(15-25(29)44-33)42-26-18-41-17-23(16-35)43-26/h5-15,23,26-28,30,35-36,38H,16-18H2,1-4H3/t23-,26+,27+,28+,30+,32-,33-/m0/s1 YZZOWMCNPSTCOM-CVGIZIDSSA-N 50397431 CHEMBL2170561 Eukaryotic initiation factor 4A-I Homo sapiens 23 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397431&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455192 163346455 CHEMBL2170561 ZINC95552612 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969005 CO[C@@H]1OC[C@@H](O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)N(C)C)c1ccccc1)c1ccc(OC)cc1)[C@@H](O)CO InChI=1S/C35H41NO12/c1-36(2)31(40)27-28(19-9-7-6-8-10-19)35(20-11-13-21(42-3)14-12-20)34(41,30(27)39)29-24(43-4)15-22(16-25(29)48-35)46-33-32(44-5)45-18-26(47-33)23(38)17-37/h6-16,23,26-28,30,32-33,37-39,41H,17-18H2,1-5H3/t23-,26+,27+,28+,30+,32+,33+,34-,35-/m0/s1 WACSSQGELZNGOK-STYOYIMCSA-N 50397432 CHEMBL2170560 Eukaryotic initiation factor 4A-I Homo sapiens 19 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397432&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 11534812 163346456 CHEMBL2170560 ZINC95556339 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969006 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(cc1)C#N)cc(OC)cc3OC InChI=1S/C28H25NO7/c1-33-19-13-20(34-2)24-21(14-19)36-28(18-11-9-16(15-29)10-12-18)23(17-7-5-4-6-8-17)22(26(31)35-3)25(30)27(24,28)32/h4-14,22-23,25,30,32H,1-3H3/t22-,23-,25-,27+,28+/m1/s1 MZIWUVAPRYAGMM-GWNOIRNCSA-N 50397414 CHEMBL2170559 Eukaryotic initiation factor 4A-I Homo sapiens 17 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397414&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71458846 163346438 CHEMBL2170559 ZINC95554552 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969007 COc1ccc(cc1)[C@@]12Oc3cc(Cl)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C InChI=1S/C28H28ClNO6/c1-30(2)26(32)22-23(16-8-6-5-7-9-16)28(17-10-12-19(34-3)13-11-17)27(33,25(22)31)24-20(35-4)14-18(29)15-21(24)36-28/h5-15,22-23,25,31,33H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 QGAOOBALZRBQLX-GWNOIRNCSA-N 50397420 CHEMBL2170563 Eukaryotic initiation factor 4A-I Homo sapiens 15 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397420&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455193 163346444 CHEMBL2170563 ZINC95557348 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969008 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C#N InChI=1S/C28H25NO7/c1-33-19-11-9-18(10-12-19)28-23(17-7-5-4-6-8-17)22(26(31)35-3)25(30)27(28,32)24-20(34-2)13-16(15-29)14-21(24)36-28/h4-14,22-23,25,30,32H,1-3H3/t22-,23-,25-,27+,28+/m1/s1 WRACOSLBAUYQOQ-GWNOIRNCSA-N 50397418 CHEMBL2170556 Eukaryotic initiation factor 4A-I Homo sapiens 15 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397418&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456983 163346442 CHEMBL2170556 ZINC95555137 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969009 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1COC[C@@H](O1)[C@H](O)CO)cc3OC InChI=1S/C33H36O12/c1-39-20-11-9-19(10-12-20)33-28(18-7-5-4-6-8-18)27(31(37)41-3)30(36)32(33,38)29-23(40-2)13-21(14-24(29)45-33)43-26-17-42-16-25(44-26)22(35)15-34/h4-14,22,25-28,30,34-36,38H,15-17H2,1-3H3/t22-,25-,26-,27-,28-,30-,32+,33+/m1/s1 VLLCANNFGBMAID-BLVHDQTMSA-N 50397413 CHEMBL2170725 Eukaryotic initiation factor 4A-I Homo sapiens 14 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397413&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456989 163346437 CHEMBL2170725 ZINC95557022 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969010 CNc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C28H29NO7/c1-29-18-14-20(34-3)24-21(15-18)36-28(17-10-12-19(33-2)13-11-17)23(16-8-6-5-7-9-16)22(26(31)35-4)25(30)27(24,28)32/h5-15,22-23,25,29-30,32H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 YXQHJBAHHCCSAR-GWNOIRNCSA-N 50397433 CHEMBL2170709 Eukaryotic initiation factor 4A-I Homo sapiens 11 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397433&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71460661 163346457 CHEMBL2170709 ZINC95553744 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969011 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC InChI=1S/C28H28O8/c1-32-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(30)35-4)25(29)27(28,31)24-20(34-3)14-19(33-2)15-21(24)36-28/h5-15,22-23,25,29,31H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 VFTGDXPPYSWBSO-GWNOIRNCSA-N 50397434 AGLAFOLIN Eukaryotic initiation factor 4A-I Homo sapiens 10 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397434&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 393601 163346458 65374 ZINC05922875 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969012 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O)cc3OC InChI=1S/C27H26O8/c1-32-18-11-9-16(10-12-18)27-22(15-7-5-4-6-8-15)21(25(30)34-3)24(29)26(27,31)23-19(33-2)13-17(28)14-20(23)35-27/h4-14,21-22,24,28-29,31H,1-3H3/t21-,22-,24-,26+,27+/m1/s1 HYLOONIBWUNKDH-PXIJUOARSA-N 50397435 CHEMBL2170724 Eukaryotic initiation factor 4A-I Homo sapiens 10 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397435&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 24178739 163346459 CHEMBL2170724 ZINC95554145 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969013 CO[C@@H]1OC[C@@H](O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1)[C@H](O)CO InChI=1S/C34H38O13/c1-40-20-12-10-19(11-13-20)34-27(18-8-6-5-7-9-18)26(30(38)42-3)29(37)33(34,39)28-23(41-2)14-21(15-24(28)47-34)45-32-31(43-4)44-17-25(46-32)22(36)16-35/h5-15,22,25-27,29,31-32,35-37,39H,16-17H2,1-4H3/t22-,25-,26-,27-,29-,31-,32-,33+,34+/m1/s1 GVKXFVCXBFGBCD-QKDMMWSPSA-N 50335583 CHEMBL555196::silvestrol Eukaryotic initiation factor 4A-I Homo sapiens 7 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50335583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50335583&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 11787114 125085685 66484 CHEMBL555196 ZINC95099283 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969014 CO[C@@H]1OC[C@H](CCO)O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31+,32-,33-,34-/m0/s1 FHFGXZOISSRNIH-VVGMJCCQSA-N 50397417 CHEMBL2170714 Eukaryotic initiation factor 4A-I Homo sapiens 5 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397417&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455199 163346441 CHEMBL2170714 ZINC95557391 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969015 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(C)cc1)cc(OC)cc3OC InChI=1S/C28H28O7/c1-16-10-12-18(13-11-16)28-23(17-8-6-5-7-9-17)22(26(30)34-4)25(29)27(28,31)24-20(33-3)14-19(32-2)15-21(24)35-28/h5-15,22-23,25,29,31H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 QJLHXGXDXMLJLM-GWNOIRNCSA-N 50397436 CHEMBL2170558 Eukaryotic initiation factor 4A-I Homo sapiens 5 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397436&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71453479 163346460 CHEMBL2170558 ZINC95555524 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969016 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(=O)OC InChI=1S/C29H28O9/c1-34-19-12-10-18(11-13-19)29-23(16-8-6-5-7-9-16)22(27(32)37-4)25(30)28(29,33)24-20(35-2)14-17(26(31)36-3)15-21(24)38-29/h5-15,22-23,25,30,33H,1-4H3/t22-,23-,25-,28+,29+/m1/s1 PFGXGRUGXUDDMN-VBIJGHLJSA-N 50397421 CHEMBL2170713 Eukaryotic initiation factor 4A-I Homo sapiens 4 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397421&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71458852 163346445 CHEMBL2170713 ZINC95556201 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969017 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(Cl)cc3OC InChI=1S/C27H25ClO7/c1-32-18-11-9-16(10-12-18)27-22(15-7-5-4-6-8-15)21(25(30)34-3)24(29)26(27,31)23-19(33-2)13-17(28)14-20(23)35-27/h4-14,21-22,24,29,31H,1-3H3/t21-,22-,24-,26+,27+/m1/s1 FAWAZAWGOJUXDV-PXIJUOARSA-N 50397423 CHEMBL2170557 Eukaryotic initiation factor 4A-I Homo sapiens 4 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397423&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462367 163346447 CHEMBL2170557 ZINC95556887 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969018 COc1ccc(cc1)[C@@]12Oc3cc(O[C@H]4COC[C@H](CO)O4)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C InChI=1S/C33H37NO10/c1-34(2)31(37)27-28(19-8-6-5-7-9-19)33(20-10-12-21(39-3)13-11-20)32(38,30(27)36)29-24(40-4)14-22(15-25(29)44-33)42-26-18-41-17-23(16-35)43-26/h5-15,23,26-28,30,35-36,38H,16-18H2,1-4H3/t23-,26+,27+,28+,30+,32-,33-/m0/s1 YZZOWMCNPSTCOM-CVGIZIDSSA-N 50397431 CHEMBL2170561 Eukaryotic initiation factor 4A-I Homo sapiens 3 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397431 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397431&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455192 163346455 CHEMBL2170561 ZINC95552612 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969019 CO[C@@H]1OC[C@@H](O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)N(C)C)c1ccccc1)c1ccc(OC)cc1)[C@@H](O)CO InChI=1S/C35H41NO12/c1-36(2)31(40)27-28(19-9-7-6-8-10-19)35(20-11-13-21(42-3)14-12-20)34(41,30(27)39)29-24(43-4)15-22(16-25(29)48-35)46-33-32(44-5)45-18-26(47-33)23(38)17-37/h6-16,23,26-28,30,32-33,37-39,41H,17-18H2,1-5H3/t23-,26+,27+,28+,30+,32+,33+,34-,35-/m0/s1 WACSSQGELZNGOK-STYOYIMCSA-N 50397432 CHEMBL2170560 Eukaryotic initiation factor 4A-I Homo sapiens 3 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397432 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397432&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 11534812 163346456 CHEMBL2170560 ZINC95556339 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969020 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1COC[C@H](CO)O1)cc3OC InChI=1S/C32H34O11/c1-37-20-11-9-19(10-12-20)32-27(18-7-5-4-6-8-18)26(30(35)39-3)29(34)31(32,36)28-23(38-2)13-21(14-24(28)43-32)41-25-17-40-16-22(15-33)42-25/h4-14,22,25-27,29,33-34,36H,15-17H2,1-3H3/t22-,25+,26+,27+,29+,31-,32-/m0/s1 OVOVDBXSEFZMNO-ZYULIPTCSA-N 50397425 CHEMBL2170722 Eukaryotic initiation factor 4A-I Homo sapiens 3 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397425&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455200 163346449 CHEMBL2170722 ZINC95554592 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969021 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(=O)N(C)C InChI=1S/C30H31NO8/c1-31(2)27(33)18-15-21(37-4)25-22(16-18)39-30(19-11-13-20(36-3)14-12-19)24(17-9-7-6-8-10-17)23(28(34)38-5)26(32)29(25,30)35/h6-16,23-24,26,32,35H,1-5H3/t23-,24-,26-,29+,30+/m1/s1 GFOFSZZGBBJUPO-XCRMWBDFSA-N 50397437 CHEMBL2170554 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397437&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455191 163346461 CHEMBL2170554 ZINC95556335 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969022 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(O)=O InChI=1S/C28H26O9/c1-34-18-11-9-17(10-12-18)28-22(15-7-5-4-6-8-15)21(26(32)36-3)24(29)27(28,33)23-19(35-2)13-16(25(30)31)14-20(23)37-28/h4-14,21-22,24,29,33H,1-3H3,(H,30,31)/t21-,22-,24-,27+,28+/m1/s1 JMJMNCVXVBQMLE-BIKHGDPZSA-N 50397438 CHEMBL2170712 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397438&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71449839 163346462 CHEMBL2170712 ZINC95555177 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969023 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(NS(C)(=O)=O)cc3OC InChI=1S/C28H29NO9S/c1-35-19-12-10-17(11-13-19)28-23(16-8-6-5-7-9-16)22(26(31)37-3)25(30)27(28,32)24-20(36-2)14-18(15-21(24)38-28)29-39(4,33)34/h5-15,22-23,25,29-30,32H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 VOEPQQVBOOUHLA-GWNOIRNCSA-N 50397439 CHEMBL2170711 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397439&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462375 163346463 CHEMBL2170711 ZINC95557066 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969024 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)N(C)C InChI=1S/C29H31NO7/c1-30(2)19-15-21(35-4)25-22(16-19)37-29(18-11-13-20(34-3)14-12-18)24(17-9-7-6-8-10-17)23(27(32)36-5)26(31)28(25,29)33/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 WCPIWTNROBMQAL-IDAMAFBJSA-N 50397440 CHEMBL2170710 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397440&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71458851 163346464 CHEMBL2170710 ZINC95556534 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969027 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1CN(C)C[C@@H](CO)O1)cc3OC InChI=1S/C33H37NO10/c1-34-16-23(18-35)43-26(17-34)42-22-14-24(40-3)29-25(15-22)44-33(20-10-12-21(39-2)13-11-20)28(19-8-6-5-7-9-19)27(31(37)41-4)30(36)32(29,33)38/h5-15,23,26-28,30,35-36,38H,16-18H2,1-4H3/t23-,26+,27+,28+,30+,32-,33-/m0/s1 CQOOLIUECQEFKP-CVGIZIDSSA-N 50397443 CHEMBL2170705 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397443&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462374 163346467 CHEMBL2170705 ZINC95552677 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969028 CO[C@H]1OC[C@H](CO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C33H36O12/c1-38-20-12-10-19(11-13-20)33-26(18-8-6-5-7-9-18)25(29(36)40-3)28(35)32(33,37)27-23(39-2)14-21(15-24(27)45-33)43-31-30(41-4)42-17-22(16-34)44-31/h5-15,22,25-26,28,30-31,34-35,37H,16-17H2,1-4H3/t22-,25+,26+,28+,30-,31-,32-,33-/m0/s1 XCYFZWJSUGHZTC-UMRPHJNKSA-N 50397444 CHEMBL2170721 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397444&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71460663 163346468 CHEMBL2170721 ZINC95556922 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969029 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(=O)N(C)C InChI=1S/C30H31NO8/c1-31(2)27(33)18-15-21(37-4)25-22(16-18)39-30(19-11-13-20(36-3)14-12-19)24(17-9-7-6-8-10-17)23(28(34)38-5)26(32)29(25,30)35/h6-16,23-24,26,32,35H,1-5H3/t23-,24-,26-,29+,30+/m1/s1 GFOFSZZGBBJUPO-XCRMWBDFSA-N 50397437 CHEMBL2170554 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397437&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71455191 163346461 CHEMBL2170554 ZINC95556335 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969030 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(NS(C)(=O)=O)cc3OC InChI=1S/C28H29NO9S/c1-35-19-12-10-17(11-13-19)28-23(16-8-6-5-7-9-16)22(26(31)37-3)25(30)27(28,32)24-20(36-2)14-18(15-21(24)38-28)29-39(4,33)34/h5-15,22-23,25,29-30,32H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 VOEPQQVBOOUHLA-GWNOIRNCSA-N 50397439 CHEMBL2170711 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397439&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462375 163346463 CHEMBL2170711 ZINC95557066 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969031 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(C)cc3OC InChI=1S/C28H28O7/c1-16-14-20(33-3)24-21(15-16)35-28(18-10-12-19(32-2)13-11-18)23(17-8-6-5-7-9-17)22(26(30)34-4)25(29)27(24,28)31/h5-15,22-23,25,29,31H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 CZUPKYVTIMIXKO-GWNOIRNCSA-N 50397441 CHEMBL2170707 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397441&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456987 163346465 CHEMBL2170707 ZINC95553764 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969032 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1CN(C)C[C@@H](CO)O1)cc3OC InChI=1S/C33H37NO10/c1-34-16-23(18-35)43-26(17-34)42-22-14-24(40-3)29-25(15-22)44-33(20-10-12-21(39-2)13-11-20)28(19-8-6-5-7-9-19)27(31(37)41-4)30(36)32(29,33)38/h5-15,23,26-28,30,35-36,38H,16-18H2,1-4H3/t23-,26+,27+,28+,30+,32-,33-/m0/s1 CQOOLIUECQEFKP-CVGIZIDSSA-N 50397443 CHEMBL2170705 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397443&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462374 163346467 CHEMBL2170705 ZINC95552677 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969033 CO[C@@H]1OC[C@H](CCO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31+,32+,33-,34-/m0/s1 FHFGXZOISSRNIH-VOUWLVCMSA-N 50397445 CHEMBL2170715 Eukaryotic initiation factor 4A-I Homo sapiens >3500 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397445&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71453486 163346469 CHEMBL2170715 ZINC95554174 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969034 CO[C@H]1OC[C@H](CO)O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C33H36O12/c1-38-20-12-10-19(11-13-20)33-26(18-8-6-5-7-9-18)25(29(36)40-3)28(35)32(33,37)27-23(39-2)14-21(15-24(27)45-33)43-31-30(41-4)42-17-22(16-34)44-31/h5-15,22,25-26,28,30-31,34-35,37H,16-17H2,1-4H3/t22-,25+,26+,28+,30-,31+,32-,33-/m0/s1 XCYFZWJSUGHZTC-BWRNHTRDSA-N 50397446 CHEMBL2170720 Eukaryotic initiation factor 4A-I Homo sapiens >2500 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397446&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71451654 163346470 CHEMBL2170720 ZINC95556615 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969035 CO[C@H]1OC[C@H](CCO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31-,32+,33-,34-/m0/s1 FHFGXZOISSRNIH-UJJRIMBNSA-N 50397447 CHEMBL2170717 Eukaryotic initiation factor 4A-I Homo sapiens >2000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397447&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71451653 163346471 CHEMBL2170717 ZINC95557594 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969036 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)N(C)C InChI=1S/C29H31NO7/c1-30(2)19-15-21(35-4)25-22(16-19)37-29(18-11-13-20(34-3)14-12-18)24(17-9-7-6-8-10-17)23(27(32)36-5)26(31)28(25,29)33/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 WCPIWTNROBMQAL-IDAMAFBJSA-N 50397440 CHEMBL2170710 Eukaryotic initiation factor 4A-I Homo sapiens >2000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397440&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71458851 163346464 CHEMBL2170710 ZINC95556534 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969037 CNC(=O)c1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C29H29NO8/c1-30-26(32)17-14-20(36-3)24-21(15-17)38-29(18-10-12-19(35-2)13-11-18)23(16-8-6-5-7-9-16)22(27(33)37-4)25(31)28(24,29)34/h5-15,22-23,25,31,34H,1-4H3,(H,30,32)/t22-,23-,25-,28+,29+/m1/s1 QGBWLAVVBBEGCQ-VBIJGHLJSA-N 50397427 CHEMBL2170553 Eukaryotic initiation factor 4A-I Homo sapiens >2000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397427&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456982 163346451 CHEMBL2170553 ZINC95553407 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969038 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(N)cc3OC InChI=1S/C27H27NO7/c1-32-18-11-9-16(10-12-18)27-22(15-7-5-4-6-8-15)21(25(30)34-3)24(29)26(27,31)23-19(33-2)13-17(28)14-20(23)35-27/h4-14,21-22,24,29,31H,28H2,1-3H3/t21-,22-,24-,26+,27+/m1/s1 LDWPQOSSUCBSKV-PXIJUOARSA-N 50397426 CHEMBL2170708 Eukaryotic initiation factor 4A-I Homo sapiens >2000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397426&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71460660 163346450 CHEMBL2170708 ZINC95555227 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969039 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cccc3OC InChI=1S/C27H26O7/c1-31-18-14-12-17(13-15-18)27-22(16-8-5-4-6-9-16)21(25(29)33-3)24(28)26(27,30)23-19(32-2)10-7-11-20(23)34-27/h4-15,21-22,24,28,30H,1-3H3/t21-,22-,24-,26+,27+/m1/s1 OEFBLIYTUODOPK-PXIJUOARSA-N 50397442 CHEMBL2170706 Eukaryotic initiation factor 4A-I Homo sapiens >2000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397442&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456986 163346466 CHEMBL2170706 ZINC95555264 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969040 CO[C@H]1OC[C@H](CO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C33H36O12/c1-38-20-12-10-19(11-13-20)33-26(18-8-6-5-7-9-18)25(29(36)40-3)28(35)32(33,37)27-23(39-2)14-21(15-24(27)45-33)43-31-30(41-4)42-17-22(16-34)44-31/h5-15,22,25-26,28,30-31,34-35,37H,16-17H2,1-4H3/t22-,25+,26+,28+,30-,31-,32-,33-/m0/s1 XCYFZWJSUGHZTC-UMRPHJNKSA-N 50397444 CHEMBL2170721 Eukaryotic initiation factor 4A-I Homo sapiens >2000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397444&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71460663 163346468 CHEMBL2170721 ZINC95556922 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969041 CO[C@@H]1OC[C@H](CCO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31+,32+,33-,34-/m0/s1 FHFGXZOISSRNIH-VOUWLVCMSA-N 50397445 CHEMBL2170715 Eukaryotic initiation factor 4A-I Homo sapiens >200 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397445&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71453486 163346469 CHEMBL2170715 ZINC95554174 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969042 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(O)=O InChI=1S/C28H26O9/c1-34-18-11-9-17(10-12-18)28-22(15-7-5-4-6-8-15)21(26(32)36-3)24(29)27(28,33)23-19(35-2)13-16(25(30)31)14-20(23)37-28/h4-14,21-22,24,29,33H,1-3H3,(H,30,31)/t21-,22-,24-,27+,28+/m1/s1 JMJMNCVXVBQMLE-BIKHGDPZSA-N 50397438 CHEMBL2170712 Eukaryotic initiation factor 4A-I Homo sapiens >1000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397438&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71449839 163346462 CHEMBL2170712 ZINC95555177 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969043 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(C)cc1)cc(OC)cc3OC InChI=1S/C28H28O7/c1-16-10-12-18(13-11-16)28-23(17-8-6-5-7-9-17)22(26(30)34-4)25(29)27(28,31)24-20(33-3)14-19(32-2)15-21(24)35-28/h5-15,22-23,25,29,31H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 QJLHXGXDXMLJLM-GWNOIRNCSA-N 50397436 CHEMBL2170558 Eukaryotic initiation factor 4A-I Homo sapiens >100 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397436&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71453479 163346460 CHEMBL2170558 ZINC95555524 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969044 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1CNC[C@@H](CO)O1)cc3OC InChI=1S/C32H35NO10/c1-38-20-11-9-19(10-12-20)32-27(18-7-5-4-6-8-18)26(30(36)40-3)29(35)31(32,37)28-23(39-2)13-21(14-24(28)43-32)41-25-16-33-15-22(17-34)42-25/h4-14,22,25-27,29,33-35,37H,15-17H2,1-3H3/t22-,25+,26+,27+,29+,31-,32-/m0/s1 XTICBJOICYVFPG-ZYULIPTCSA-N 50397422 CHEMBL2170704 Eukaryotic initiation factor 4A-I Homo sapiens 3500 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397422&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456985 163346446 CHEMBL2170704 ZINC95554113 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969045 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O[C@H]1CCC[C@@H](CO)O1)cc3OC InChI=1S/C33H36O10/c1-38-21-14-12-20(13-15-21)33-28(19-8-5-4-6-9-19)27(31(36)40-3)30(35)32(33,37)29-24(39-2)16-23(17-25(29)43-33)42-26-11-7-10-22(18-34)41-26/h4-6,8-9,12-17,22,26-28,30,34-35,37H,7,10-11,18H2,1-3H3/t22-,26-,27+,28+,30+,32-,33-/m0/s1 QJTDBNUOGMBVKE-XIDCDTCBSA-N 50397424 CHEMBL2170723 Eukaryotic initiation factor 4A-I Homo sapiens 2000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397424&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462377 163346448 CHEMBL2170723 ZINC95556205 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969046 CNc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C28H29NO7/c1-29-18-14-20(34-3)24-21(15-18)36-28(17-10-12-19(33-2)13-11-17)23(16-8-6-5-7-9-16)22(26(31)35-4)25(30)27(24,28)32/h5-15,22-23,25,29-30,32H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 YXQHJBAHHCCSAR-GWNOIRNCSA-N 50397433 CHEMBL2170709 Eukaryotic initiation factor 4A-I Homo sapiens 700 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397433&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71460661 163346457 CHEMBL2170709 ZINC95553744 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969047 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(cc3OC)C(N)=O InChI=1S/C28H27NO8/c1-34-18-11-9-17(10-12-18)28-22(15-7-5-4-6-8-15)21(26(32)36-3)24(30)27(28,33)23-19(35-2)13-16(25(29)31)14-20(23)37-28/h4-14,21-22,24,30,33H,1-3H3,(H2,29,31)/t21-,22-,24-,27+,28+/m1/s1 NDSAJVZNWSEAEP-BIKHGDPZSA-N 50397430 CHEMBL2169895 Eukaryotic initiation factor 4A-I Homo sapiens 450 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397430&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71460662 163346454 CHEMBL2169895 ZINC95554173 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969048 CO[C@H]1OC[C@H](CCO)O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31-,32-,33-,34-/m0/s1 FHFGXZOISSRNIH-SEQXORCOSA-N 50397429 CHEMBL2170716 Eukaryotic initiation factor 4A-I Homo sapiens 275 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397429&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71458853 163346453 CHEMBL2170716 ZINC95556952 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969049 CO[C@@H]1OC[C@H](CO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C33H36O12/c1-38-20-12-10-19(11-13-20)33-26(18-8-6-5-7-9-18)25(29(36)40-3)28(35)32(33,37)27-23(39-2)14-21(15-24(27)45-33)43-31-30(41-4)42-17-22(16-34)44-31/h5-15,22,25-26,28,30-31,34-35,37H,16-17H2,1-4H3/t22-,25+,26+,28+,30+,31-,32-,33-/m0/s1 XCYFZWJSUGHZTC-MQQGTTPASA-N 50397428 CHEMBL2170719 Eukaryotic initiation factor 4A-I Homo sapiens 240 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397428 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397428&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71462376 163346452 CHEMBL2170719 ZINC95555545 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969050 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(O)cc3OC InChI=1S/C27H26O8/c1-32-18-11-9-16(10-12-18)27-22(15-7-5-4-6-8-15)21(25(30)34-3)24(29)26(27,31)23-19(33-2)13-17(28)14-20(23)35-27/h4-14,21-22,24,28-29,31H,1-3H3/t21-,22-,24-,26+,27+/m1/s1 HYLOONIBWUNKDH-PXIJUOARSA-N 50397435 CHEMBL2170724 Eukaryotic initiation factor 4A-I Homo sapiens 200 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397435&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 24178739 163346459 CHEMBL2170724 ZINC95554145 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969051 CO[C@H]1OC[C@H](CO)O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C33H36O12/c1-38-20-12-10-19(11-13-20)33-26(18-8-6-5-7-9-18)25(29(36)40-3)28(35)32(33,37)27-23(39-2)14-21(15-24(27)45-33)43-31-30(41-4)42-17-22(16-34)44-31/h5-15,22,25-26,28,30-31,34-35,37H,16-17H2,1-4H3/t22-,25+,26+,28+,30-,31+,32-,33-/m0/s1 XCYFZWJSUGHZTC-BWRNHTRDSA-N 50397446 CHEMBL2170720 Eukaryotic initiation factor 4A-I Homo sapiens 170 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397446&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71451654 163346470 CHEMBL2170720 ZINC95556615 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969052 CO[C@H]1OC[C@H](CCO)O[C@@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1 InChI=1S/C34H38O12/c1-39-21-12-10-20(11-13-21)34-27(19-8-6-5-7-9-19)26(30(37)41-3)29(36)33(34,38)28-24(40-2)16-23(17-25(28)46-34)45-32-31(42-4)43-18-22(44-32)14-15-35/h5-13,16-17,22,26-27,29,31-32,35-36,38H,14-15,18H2,1-4H3/t22-,26+,27+,29+,31-,32+,33-,34-/m0/s1 FHFGXZOISSRNIH-UJJRIMBNSA-N 50397447 CHEMBL2170717 Eukaryotic initiation factor 4A-I Homo sapiens 120 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397447&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71451653 163346471 CHEMBL2170717 ZINC95557594 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969053 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(OC)cc3OC InChI=1S/C28H28O8/c1-32-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(30)35-4)25(29)27(28,31)24-20(34-3)14-19(33-2)15-21(24)36-28/h5-15,22-23,25,29,31H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 VFTGDXPPYSWBSO-GWNOIRNCSA-N 50397434 AGLAFOLIN Eukaryotic initiation factor 4A-I Homo sapiens 90 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397434&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 393601 163346458 65374 ZINC05922875 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969025 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cc(C)cc3OC InChI=1S/C28H28O7/c1-16-14-20(33-3)24-21(15-16)35-28(18-10-12-19(32-2)13-11-18)23(17-8-6-5-7-9-17)22(26(30)34-4)25(29)27(24,28)31/h5-15,22-23,25,29,31H,1-4H3/t22-,23-,25-,27+,28+/m1/s1 CZUPKYVTIMIXKO-GWNOIRNCSA-N 50397441 CHEMBL2170707 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397441&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456987 163346465 CHEMBL2170707 ZINC95553764 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50969026 COC(=O)[C@H]1[C@@H](O)[C@@]2(O)c3c(O[C@]2([C@@H]1c1ccccc1)c1ccc(OC)cc1)cccc3OC InChI=1S/C27H26O7/c1-31-18-14-12-17(13-15-18)27-22(16-8-5-4-6-9-16)21(25(29)33-3)24(28)26(27,30)23-19(32-2)10-7-11-20(23)34-27/h4-15,21-22,24,28,30H,1-3H3/t21-,22-,24-,26+,27+/m1/s1 OEFBLIYTUODOPK-PXIJUOARSA-N 50397442 CHEMBL2170706 Eukaryotic initiation factor 4A-I Homo sapiens >5000 ChEMBL 10.1021/jm3011542 10.7270/Q23R0V1X 23025805 Liu, T; Nair, SJ; Lescarbeau, A; Belani, J; Peluso, S; Conley, J; Tillotson, B; O'Hearn, P; Smith, S; Slocum, K; West, K; Helble, J; Douglas, M; Bahadoor, A; Ali, J; McGovern, K; Fritz, C; Palombella, VJ; Wylie, A; Castro, AC; Tremblay, MR Infinity Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50397442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50397442&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 71456986 163346466 CHEMBL2170706 ZINC95555264 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50726532 CC(C)c1ccc2cc([nH]c2c1F)C(O)=O InChI=1S/C12H12FNO2/c1-6(2)8-4-3-7-5-9(12(15)16)14-11(7)10(8)13/h3-6,14H,1-2H3,(H,15,16) RWVDYXCOBZNVGG-UHFFFAOYSA-N 50235740 CHEMBL4061441 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.02.035 10.7270/Q2902613 28283335 Ito, M; Iwatani, M; Kamada, Y; Sogabe, S; Nakao, S; Tanaka, T; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235740&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 137635662 384991526 CHEMBL4061441 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50726533 CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17) SOSKBOZUXWZYFU-UHFFFAOYSA-N 50235737 CHEMBL4070102 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.02.035 10.7270/Q2902613 28283335 Ito, M; Iwatani, M; Kamada, Y; Sogabe, S; Nakao, S; Tanaka, T; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235737&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 132569638 384991523 CHEMBL4070102 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50726547 CC(C)c1cc(Cl)c2cc([nH]c2c1)C(O)=O InChI=1S/C12H12ClNO2/c1-6(2)7-3-9(13)8-5-11(12(15)16)14-10(8)4-7/h3-6,14H,1-2H3,(H,15,16) ASTFAGUPUIUGCS-UHFFFAOYSA-N 50235741 CHEMBL4099717 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.02.035 10.7270/Q2902613 28283335 Ito, M; Iwatani, M; Kamada, Y; Sogabe, S; Nakao, S; Tanaka, T; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235741&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 137659545 384991527 CHEMBL4099717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50726561 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 HPHXKNOXVBFETI-SHCCRYCOSA-N 50235738 Hippuristanol Eukaryotic initiation factor 4A-I Homo sapiens 3100 ChEMBL 10.1016/j.bmc.2017.02.035 10.7270/Q2902613 28283335 Ito, M; Iwatani, M; Kamada, Y; Sogabe, S; Nakao, S; Tanaka, T; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235738&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 9981822 384991524 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50752803 OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)C2CCCCC2)o1 InChI=1S/C23H20N4O4S/c24-19-17(12-16-9-10-18(31-16)14-7-4-8-15(11-14)22(29)30)20(28)25-23-27(19)26-21(32-23)13-5-2-1-3-6-13/h4,7-13,24H,1-3,5-6H2,(H,29,30)/b17-12-,24-19? GPCYKHCHVIFLKK-XKVLWOBQSA-N 50239861 CHEMBL4092701 Eukaryotic initiation factor 4A-I Homo sapiens 57000 ChEMBL 10.1021/acs.jmedchem.7b00461 10.7270/Q2MC925G 28586220 Iwatani-Yoshihara, M; Ito, M; Klein, MG; Yamamoto, T; Yonemori, K; Tanaka, T; Miwa, M; Morishita, D; Endo, S; Tjhen, R; Qin, L; Nakanishi, A; Maezaki, H; Kawamoto, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 44449880 85716683 CHEMBL4092701 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50752811 Cc1cc2CCC(Oc2cc1N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O)c1ncccc1F InChI=1S/C29H25FN4O3/c1-18-12-20-9-10-25(28-22(30)8-5-11-31-28)37-26(20)14-24(18)34-17-21-16-33(15-19-6-3-2-4-7-19)27(35)13-23(21)32-29(34)36/h2-8,11-14,16,25H,9-10,15,17H2,1H3,(H,32,36) SQFLORLZIWQDIK-UHFFFAOYSA-N 50239863 CHEMBL4087449 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1021/acs.jmedchem.7b00461 10.7270/Q2MC925G 28586220 Iwatani-Yoshihara, M; Ito, M; Klein, MG; Yamamoto, T; Yonemori, K; Tanaka, T; Miwa, M; Morishita, D; Endo, S; Tjhen, R; Qin, L; Nakanishi, A; Maezaki, H; Kawamoto, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239863&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 44449908 85716724 CHEMBL4087449 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50752927 O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1 InChI=1S/C27H23N3O3/c31-26-15-25-22(17-29(26)16-20-8-3-1-4-9-20)18-30(27(32)28-25)23-12-7-13-24(14-23)33-19-21-10-5-2-6-11-21/h1-15,17H,16,18-19H2,(H,28,32) BHMKGMWMMMZMJN-UHFFFAOYSA-N 50239866 CHEMBL4065018 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1021/acs.jmedchem.7b00461 10.7270/Q2MC925G 28586220 Iwatani-Yoshihara, M; Ito, M; Klein, MG; Yamamoto, T; Yonemori, K; Tanaka, T; Miwa, M; Morishita, D; Endo, S; Tjhen, R; Qin, L; Nakanishi, A; Maezaki, H; Kawamoto, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239866&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 8LP 5URK 44449973 85716814 CHEMBL4065018 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50752928 O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cccnc2)c1 InChI=1S/C26H22N4O3/c31-25-13-24-21(16-29(25)15-19-6-2-1-3-7-19)17-30(26(32)28-24)22-9-4-10-23(12-22)33-18-20-8-5-11-27-14-20/h1-14,16H,15,17-18H2,(H,28,32) PSWMJOPGLAUUCC-UHFFFAOYSA-N 50239868 CHEMBL4097764 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1021/acs.jmedchem.7b00461 10.7270/Q2MC925G 28586220 Iwatani-Yoshihara, M; Ito, M; Klein, MG; Yamamoto, T; Yonemori, K; Tanaka, T; Miwa, M; Morishita, D; Endo, S; Tjhen, R; Qin, L; Nakanishi, A; Maezaki, H; Kawamoto, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239868&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 44450004 85716856 CHEMBL4097764 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50752929 O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1 InChI=1S/C24H20N4O3S/c29-23-10-22-18(13-27(23)12-17-5-2-1-3-6-17)14-28(24(30)26-22)19-7-4-8-20(9-19)31-15-21-11-25-16-32-21/h1-11,13,16H,12,14-15H2,(H,26,30) GAWVULNDIBAUHU-UHFFFAOYSA-N 50239869 CHEMBL4084949 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1021/acs.jmedchem.7b00461 10.7270/Q2MC925G 28586220 Iwatani-Yoshihara, M; Ito, M; Klein, MG; Yamamoto, T; Yonemori, K; Tanaka, T; Miwa, M; Morishita, D; Endo, S; Tjhen, R; Qin, L; Nakanishi, A; Maezaki, H; Kawamoto, T Takeda California Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50239869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50239869&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 44449216 85715658 CHEMBL4084949 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50885460 Cc1c(cnn1-c1cccc(c1)C#N)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cc1 InChI=1S/C29H23BrClN5O2/c1-19-26(17-33-36(19)25-4-2-3-20(15-25)16-32)29(38)34-13-14-35(28(37)22-5-9-23(30)10-6-22)27(18-34)21-7-11-24(31)12-8-21/h2-12,15,17,27H,13-14,18H2,1H3/t27-/m1/s1 BDGKKHWJYBQRIE-HHHXNRCGSA-N 50265561 CHEMBL4073833 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1021/acs.jmedchem.6b01904 10.7270/Q2GH9MFT 28358513 Ito, M; Tanaka, T; Cary, DR; Iwatani-Yoshihara, M; Kamada, Y; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265561&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 137640621 404857625 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50833423 CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1 CFOBSDBTRZXUQZ-AIFCEMJISA-N 50260424 CHEMBL4091579 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.07.017 10.7270/Q27M0BDH 28751196 Ito, M; Iwatani, M; Yamamoto, T; Tanaka, T; Kawamoto, T; Morishita, D; Nakanishi, A; Maezaki, H Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260424&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 132609318 404340213 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50833205 CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1 WAFNVKVWBPXGHK-CGSMKXTHSA-N 50260390 CHEMBL4070683 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.07.017 10.7270/Q27M0BDH 28751196 Ito, M; Iwatani, M; Yamamoto, T; Tanaka, T; Kawamoto, T; Morishita, D; Nakanishi, A; Maezaki, H Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260390&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 132609317 404340202 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50833209 CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m0/s1 WAFNVKVWBPXGHK-QDUSTFBWSA-N 50260425 CHEMBL4099313 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.07.017 10.7270/Q27M0BDH 28751196 Ito, M; Iwatani, M; Yamamoto, T; Tanaka, T; Kawamoto, T; Morishita, D; Nakanishi, A; Maezaki, H Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260425&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 137660917 404340214 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50833210 CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m0/s1 CFOBSDBTRZXUQZ-CLQOQPCJSA-N 50260426 CHEMBL4073413 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1016/j.bmc.2017.07.017 10.7270/Q27M0BDH 28751196 Ito, M; Iwatani, M; Yamamoto, T; Tanaka, T; Kawamoto, T; Morishita, D; Nakanishi, A; Maezaki, H Takeda Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50260426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50260426&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 137640718 404340215 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50992126 Cn1cc(cc(-c2cccc(c2)C#N)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1 InChI=1S/C30H23BrClN5O3/c1-35-17-22(14-25(29(35)39)21-4-2-3-19(13-21)15-33)28(38)36-11-12-37(30(40)26-10-7-23(31)16-34-26)27(18-36)20-5-8-24(32)9-6-20/h2-10,13-14,16-17,27H,11-12,18H2,1H3/t27-/m1/s1 BFEHRVHTPYQIGG-HHHXNRCGSA-N 50283443 CHEMBL4170030 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1021/acsmedchemlett.7b00283 10.7270/Q2QJ7KT3 29057054 Mizojiri, R; Nakata, D; Satoh, Y; Morishita, D; Shibata, S; Iwatani-Yoshihara, M; Kosugi, Y; Kosaka, M; Takeda, J; Sasaki, S; Takami, K; Fukuda, K; Kamaura, M; Sasaki, S; Arai, R; Cary, DR; Imaeda, Y Takeda Pharmaceutical Company Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283443&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 145954890 104125100 ZINC27181229 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50992128 FC(F)(F)c1cccc(c1)-c1cc(cn(-c2ccccc2)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1 InChI=1S/C35H25BrClF3N4O3/c36-26-11-14-30(41-19-26)34(47)43-16-15-42(21-31(43)22-9-12-27(37)13-10-22)32(45)24-18-29(23-5-4-6-25(17-23)35(38,39)40)33(46)44(20-24)28-7-2-1-3-8-28/h1-14,17-20,31H,15-16,21H2/t31-/m1/s1 XXRSEDBXRRRFKI-WJOKGBTCSA-N 50283445 CHEMBL4175313 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1021/acsmedchemlett.7b00283 10.7270/Q2QJ7KT3 29057054 Mizojiri, R; Nakata, D; Satoh, Y; Morishita, D; Shibata, S; Iwatani-Yoshihara, M; Kosugi, Y; Kosaka, M; Takeda, J; Sasaki, S; Takami, K; Fukuda, K; Kamaura, M; Sasaki, S; Arai, R; Cary, DR; Imaeda, Y Takeda Pharmaceutical Company Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50283445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50283445&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 145950448 104125102 ZINC34799951 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 50992144 Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1 WKKAVTNXNVPCCN-HSZRJFAPSA-N 65493 eIF4A3 inhibitor, 2 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1021/acsmedchemlett.7b00283 10.7270/Q2QJ7KT3 29057054 Mizojiri, R; Nakata, D; Satoh, Y; Morishita, D; Shibata, S; Iwatani-Yoshihara, M; Kosugi, Y; Kosaka, M; Takeda, J; Sasaki, S; Takami, K; Fukuda, K; Kamaura, M; Sasaki, S; Arai, R; Cary, DR; Imaeda, Y Takeda Pharmaceutical Company Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=65493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=65493&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 131953885 350083116 ZINC25390470 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174549 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5C(=O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H44O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-19,21-23,29,31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,21-,22+,23-,25-,26-,27+,28+/m0/s1 PYYCTSSONOEHSO-ZKCZLJCTSA-N 50482550 CHEMBL1222374::Hippuristanol 11-One Eukaryotic initiation factor 4A-I Homo sapiens 9000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482550&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 49864734 433949815 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174550 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6CC(=O)CC[C@]6(C)[C@H]5C(=O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H42O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-16,18-19,21-23,31H,7-14H2,1-6H3/t15-,16-,18-,19-,21-,22+,23-,25-,26-,27+,28+/m0/s1 WLRBBKMWBNEBAR-WXRQRNGESA-N 50482551 CHEMBL1222375::Hippuristanol 3,11-Dione Eukaryotic initiation factor 4A-I Homo sapiens 52000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482551&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 49864735 433949816 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174551 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](OC(C)=O)[C@H](O)C[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C30H48O7/c1-15-12-30(37-26(15,3)4)29(7,34)25-23(36-30)11-19-18-9-8-17-10-22(35-16(2)31)20(32)13-27(17,5)24(18)21(33)14-28(19,25)6/h15,17-25,32-34H,8-14H2,1-7H3/t15-,17-,18-,19-,20+,21-,22-,23-,24+,25-,27-,28-,29+,30+/m0/s1 CLRGSPLGNCTOOL-YKVVPRMGSA-N 50482552 CHEMBL507260 Eukaryotic initiation factor 4A-I Homo sapiens 1700 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482552&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 11443805 433949817 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174552 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)[C@@H](C[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC(=O)CCCC(O)=O)OC1(C)C InChI=1S/C33H52O9/c1-17-14-33(42-29(17,2)3)32(6,39)28-23(41-33)13-20-19-11-10-18-12-21(34)24(40-26(38)9-7-8-25(36)37)16-30(18,4)27(19)22(35)15-31(20,28)5/h17-24,27-28,34-35,39H,7-16H2,1-6H3,(H,36,37)/t17-,18-,19-,20-,21-,22-,23-,24+,27+,28-,30-,31-,32+,33+/m0/s1 VHVPOWPLZYOWAX-RLQAJPSBSA-N 50482553 CHEMBL1222377 Eukaryotic initiation factor 4A-I Homo sapiens 2600 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482553&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 20833543 433949818 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174553 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC(C)=O)OC1(C)C InChI=1S/C30H48O6/c1-16-14-30(36-26(16,3)4)29(7,33)25-23(35-30)13-21-20-9-8-18-12-19(34-17(2)31)10-11-27(18,5)24(20)22(32)15-28(21,25)6/h16,18-25,32-33H,8-15H2,1-7H3/t16-,18-,19+,20-,21-,22-,23-,24+,25-,27-,28-,29+,30-/m0/s1 NMENKWADYNCEKW-CAYRAOEMSA-N 50482554 CHEMBL1221460::Epihippuristanol 3-Acetate Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482554&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 10791645 433949819 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174554 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5C(=O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H44O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-19,21-23,29,31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,21-,22+,23-,25-,26-,27+,28-/m0/s1 PYYCTSSONOEHSO-GORAVFDGSA-N 50482555 CHEMBL1221463::Epihippuristanol 11-One Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482555&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 11453970 433949820 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174555 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)[C@@H](C[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC(C)=O)OC1(C)C InChI=1S/C30H48O7/c1-15-12-30(37-26(15,3)4)29(7,34)25-22(36-30)11-19-18-9-8-17-10-20(32)23(35-16(2)31)14-27(17,5)24(18)21(33)13-28(19,25)6/h15,17-25,32-34H,8-14H2,1-7H3/t15-,17-,18-,19-,20-,21-,22-,23+,24+,25-,27-,28-,29+,30-/m0/s1 HRJBSUKSBJIMML-JQXFSTGHSA-N 50482556 Epihippurin 1 Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482556&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 128330 433949821 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174556 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](OC(C)=O)[C@H](O)C[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C30H48O7/c1-15-12-30(37-26(15,3)4)29(7,34)25-23(36-30)11-19-18-9-8-17-10-22(35-16(2)31)20(32)13-27(17,5)24(18)21(33)14-28(19,25)6/h15,17-25,32-34H,8-14H2,1-7H3/t15-,17-,18-,19-,20+,21-,22-,23-,24+,25-,27-,28-,29+,30-/m0/s1 CLRGSPLGNCTOOL-AYFPVZIASA-N 50482557 CHEMBL506697 Eukaryotic initiation factor 4A-I Homo sapiens 52000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482557&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 20833540 433949822 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174557 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](CC[C@]6(C)[C@H]5[C@@H](O)C[C@@]44[C@H](O)O[C@]2(C)[C@@H]34)OC(C)=O)OC1(C)C InChI=1S/C30H46O7/c1-15-13-30(37-26(15,3)4)28(6)24-22(35-30)12-20-19-8-7-17-11-18(34-16(2)31)9-10-27(17,5)23(19)21(32)14-29(20,24)25(33)36-28/h15,17-25,32-33H,7-14H2,1-6H3/t15-,17-,18+,19-,20-,21-,22-,23+,24+,25+,27-,28+,29+,30-/m0/s1 QIIQIIUEZGRUMJ-IXDUNUBMSA-N 50482558 Hippuristanohemiacetal Eukaryotic initiation factor 4A-I Homo sapiens 91000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482558&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 11179910 433949823 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174558 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)[C@H](O)C[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H46O6/c1-14-11-28(34-24(14,2)3)27(6,32)23-21(33-28)10-17-16-8-7-15-9-18(29)19(30)12-25(15,4)22(16)20(31)13-26(17,23)5/h14-23,29-32H,7-13H2,1-6H3/t14-,15-,16-,17-,18-,19+,20-,21-,22+,23-,25-,26-,27+,28-/m0/s1 BCZIXMFNQQMCFI-LMGJWPTFSA-N 50482559 CHEMBL457151 Eukaryotic initiation factor 4A-I Homo sapiens 19000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482559&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 20833541 433949824 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174559 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 HPHXKNOXVBFETI-SHCCRYCOSA-N 50235738 Hippuristanol Eukaryotic initiation factor 4A-I Homo sapiens 400 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235738&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 9981822 384991524 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174560 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC(C)=O)OC1(C)C InChI=1S/C30H48O6/c1-16-14-30(36-26(16,3)4)29(7,33)25-23(35-30)13-21-20-9-8-18-12-19(34-17(2)31)10-11-27(18,5)24(20)22(32)15-28(21,25)6/h16,18-25,32-33H,8-15H2,1-7H3/t16-,18-,19+,20-,21-,22-,23-,24+,25-,27-,28-,29+,30+/m0/s1 NMENKWADYNCEKW-ZJJHCSDUSA-N 50482560 CHEMBL1222308::Hippuristanol 3-Acetate Eukaryotic initiation factor 4A-I Homo sapiens 10000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482560&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 20833538 433949825 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174561 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](CC[C@]6(C)[C@H]5[C@H](C[C@]4(C)[C@H]3[C@@]2(C)O)OC(C)=O)OC(C)=O)OC1(C)C InChI=1S/C32H50O7/c1-17-15-32(39-28(17,4)5)31(8,35)27-24(38-32)14-23-22-10-9-20-13-21(36-18(2)33)11-12-29(20,6)26(22)25(37-19(3)34)16-30(23,27)7/h17,20-27,35H,9-16H2,1-8H3/t17-,20-,21+,22-,23-,24-,25-,26+,27-,29-,30-,31+,32-/m0/s1 HARCSUAWZPMYFG-IXKUNMSQSA-N 50482561 CHEMBL1221461::Epihippuristanol 3,11-Diacetate Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482561&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 10530631 433949826 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174562 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@@H](CC[C@]6(C)[C@H]5[C@H](C[C@]4(C)[C@H]3[C@@]2(C)O)OC(C)=O)OC(C)=O)OC1(C)C InChI=1S/C32H50O7/c1-17-15-32(39-28(17,4)5)31(8,35)27-24(38-32)14-23-22-10-9-20-13-21(36-18(2)33)11-12-29(20,6)26(22)25(37-19(3)34)16-30(23,27)7/h17,20-27,35H,9-16H2,1-8H3/t17-,20-,21+,22-,23-,24-,25-,26+,27-,29-,30-,31+,32+/m0/s1 HARCSUAWZPMYFG-RZGJQPHQSA-N 50482562 CHEMBL1222309::Hippuristanol 3,11-Diacetate Eukaryotic initiation factor 4A-I Homo sapiens 64000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482562&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 20833539 433949827 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174563 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)[C@@H](C[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC(C)=O)OC1(C)C InChI=1S/C30H48O7/c1-15-12-30(37-26(15,3)4)29(7,34)25-22(36-30)11-19-18-9-8-17-10-20(32)23(35-16(2)31)14-27(17,5)24(18)21(33)13-28(19,25)6/h15,17-25,32-34H,8-14H2,1-7H3/t15-,17-,18-,19-,20-,21-,22-,23+,24+,25-,27-,28-,29+,30+/m0/s1 HRJBSUKSBJIMML-DVPIGBGPSA-N 50482563 CHEMBL449854::Hippurin-1 Eukaryotic initiation factor 4A-I Homo sapiens 1500 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482563&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 11504572 433949828 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174564 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6CC(=O)CC[C@]6(C)[C@H]5C(=O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H42O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-16,18-19,21-23,31H,7-14H2,1-6H3/t15-,16-,18-,19-,21-,22+,23-,25-,26-,27+,28-/m0/s1 WLRBBKMWBNEBAR-RHEOOMQSSA-N 50482564 CHEMBL1221464::Epihippuristanol 3,11-Dione Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482564&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 49864296 433949829 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174565 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)[C@@H](C[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC(=O)CCCC(O)=O)OC1(C)C InChI=1S/C33H52O9/c1-17-14-33(42-29(17,2)3)32(6,39)28-23(41-33)13-20-19-11-10-18-12-21(34)24(40-26(38)9-7-8-25(36)37)16-30(18,4)27(19)22(35)15-31(20,28)5/h17-24,27-28,34-35,39H,7-16H2,1-6H3,(H,36,37)/t17-,18-,19-,20-,21-,22-,23-,24+,27+,28-,30-,31-,32+,33-/m0/s1 VHVPOWPLZYOWAX-DBRGUQOTSA-N 50482565 CHEMBL1221511 Eukaryotic initiation factor 4A-I Homo sapiens 35000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482565&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 20833545 433949830 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174566 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)[C@H](O)C[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H46O6/c1-14-11-28(34-24(14,2)3)27(6,32)23-21(33-28)10-17-16-8-7-15-9-18(29)19(30)12-25(15,4)22(16)20(31)13-26(17,23)5/h14-23,29-32H,7-13H2,1-6H3/t14-,15-,16-,17-,18-,19+,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 BCZIXMFNQQMCFI-JYOCPGMCSA-N 50482566 CHEMBL1222376 Eukaryotic initiation factor 4A-I Homo sapiens 1700 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482566&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 21669902 433949831 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51174567 C[C@H]1C[C@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28-/m0/s1 HPHXKNOXVBFETI-FELJEYOCSA-N 50482567 22-Epi-Hippuristanol::Epihippuristanol Eukaryotic initiation factor 4A-I Homo sapiens >100000 ChEMBL 10.1038/nchembio776 10.7270/Q2F47RZB 16532013 Bordeleau, ME; Mori, A; Oberer, M; Lindqvist, L; Chard, LS; Higa, T; Belsham, GJ; Wagner, G; Tanaka, J; Pelletier, J McGill University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50482567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50482567&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 330750 433949832 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336290 COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 QYCXWOACFWMQFO-WZWZCULESA-N 50540861 EFT-226::Eft226::Zotatifin Eukaryotic initiation factor 4A-I Homo sapiens 6.3 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138801 442142424 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336291 COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 DAPAQENNNINUPW-IDAMAFBJSA-N 50196926 CHEMBL438139::Rocaglamide::US10085988, Compound (-) Roc-A Eukaryotic initiation factor 4A-I Homo sapiens 156 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196926&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search RCG 5ZC9 331783 104078455 66309 CHEMBL438139 ZINC05664046 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336292 COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 QYCXWOACFWMQFO-WZWZCULESA-N 50540861 EFT-226::Eft226::Zotatifin Eukaryotic initiation factor 4A-I Homo sapiens 21 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138801 442142424 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336293 COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 QYCXWOACFWMQFO-WZWZCULESA-N 50540861 EFT-226::Eft226::Zotatifin Eukaryotic initiation factor 4A-I Homo sapiens 3190 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138801 442142424 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336294 COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 QYCXWOACFWMQFO-WZWZCULESA-N 50540861 EFT-226::Eft226::Zotatifin Eukaryotic initiation factor 4A-I Homo sapiens 9600 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138801 442142424 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336295 COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 QYCXWOACFWMQFO-WZWZCULESA-N 50540861 EFT-226::Eft226::Zotatifin Eukaryotic initiation factor 4A-I Homo sapiens 2430 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138801 442142424 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336296 COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 DAPAQENNNINUPW-IDAMAFBJSA-N 50196926 CHEMBL438139::Rocaglamide::US10085988, Compound (-) Roc-A Eukaryotic initiation factor 4A-I Homo sapiens 4.7 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196926&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search RCG 5ZC9 331783 104078455 66309 CHEMBL438139 ZINC05664046 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336297 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 HPHXKNOXVBFETI-SHCCRYCOSA-N 50235738 Hippuristanol Eukaryotic initiation factor 4A-I Homo sapiens 426 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235738&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 9981822 384991524 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336298 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1 InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 YPHMISFOHDHNIV-FSZOTQKASA-N 50080528 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide::4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione::CHEMBL123292::Cycloheximid::Zykloheximid::cid_6197::cycloheximide::med.21724, Compound Cycloheximide Eukaryotic initiation factor 4A-I Homo sapiens 226 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080528&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 3HE 6HD7,8G6J,7R81,6Y2L,7N8B,4U3U,6Y0G,7Q08,5GAK,6TNU,5LKS 6197 103980685 27641 CHEMBL123292 5433 C06685 ZINC03872170 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336299 COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 DAPAQENNNINUPW-IDAMAFBJSA-N 50196926 CHEMBL438139::Rocaglamide::US10085988, Compound (-) Roc-A Eukaryotic initiation factor 4A-I Homo sapiens 47 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196926&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search RCG 5ZC9 331783 104078455 66309 CHEMBL438139 ZINC05664046 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336300 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 HPHXKNOXVBFETI-SHCCRYCOSA-N 50235738 Hippuristanol Eukaryotic initiation factor 4A-I Homo sapiens 369 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235738&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 9981822 384991524 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336301 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1 InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 YPHMISFOHDHNIV-FSZOTQKASA-N 50080528 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide::4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione::CHEMBL123292::Cycloheximid::Zykloheximid::cid_6197::cycloheximide::med.21724, Compound Cycloheximide Eukaryotic initiation factor 4A-I Homo sapiens 101 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080528&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 3HE 6HD7,8G6J,7R81,6Y2L,7N8B,4U3U,6Y0G,7Q08,5GAK,6TNU,5LKS 6197 103980685 27641 CHEMBL123292 5433 C06685 ZINC03872170 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336302 COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 DAPAQENNNINUPW-IDAMAFBJSA-N 50196926 CHEMBL438139::Rocaglamide::US10085988, Compound (-) Roc-A Eukaryotic initiation factor 4A-I Homo sapiens 135 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196926&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search RCG 5ZC9 331783 104078455 66309 CHEMBL438139 ZINC05664046 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336303 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 HPHXKNOXVBFETI-SHCCRYCOSA-N 50235738 Hippuristanol Eukaryotic initiation factor 4A-I Homo sapiens 210 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235738&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 9981822 384991524 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336304 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1 InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 YPHMISFOHDHNIV-FSZOTQKASA-N 50080528 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide::4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione::CHEMBL123292::Cycloheximid::Zykloheximid::cid_6197::cycloheximide::med.21724, Compound Cycloheximide Eukaryotic initiation factor 4A-I Homo sapiens 87 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080528&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 3HE 6HD7,8G6J,7R81,6Y2L,7N8B,4U3U,6Y0G,7Q08,5GAK,6TNU,5LKS 6197 103980685 27641 CHEMBL123292 5433 C06685 ZINC03872170 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336305 COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 DAPAQENNNINUPW-IDAMAFBJSA-N 50196926 CHEMBL438139::Rocaglamide::US10085988, Compound (-) Roc-A Eukaryotic initiation factor 4A-I Homo sapiens 231 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50196926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50196926&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search RCG 5ZC9 331783 104078455 66309 CHEMBL438139 ZINC05664046 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336306 C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 HPHXKNOXVBFETI-SHCCRYCOSA-N 50235738 Hippuristanol Eukaryotic initiation factor 4A-I Homo sapiens 204 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235738&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 9981822 384991524 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336307 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1 InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 YPHMISFOHDHNIV-FSZOTQKASA-N 50080528 3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide::4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione::CHEMBL123292::Cycloheximid::Zykloheximid::cid_6197::cycloheximide::med.21724, Compound Cycloheximide Eukaryotic initiation factor 4A-I Homo sapiens 142 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080528&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 3HE 6HD7,8G6J,7R81,6Y2L,7N8B,4U3U,6Y0G,7Q08,5GAK,6TNU,5LKS 6197 103980685 27641 CHEMBL123292 5433 C06685 ZINC03872170 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336308 COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 QYCXWOACFWMQFO-WZWZCULESA-N 50540861 EFT-226::Eft226::Zotatifin Eukaryotic initiation factor 4A-I Homo sapiens 1.5 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138801 442142424 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336309 COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 QYCXWOACFWMQFO-WZWZCULESA-N 50540861 EFT-226::Eft226::Zotatifin Eukaryotic initiation factor 4A-I Homo sapiens 14 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138801 442142424 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336310 COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 QYCXWOACFWMQFO-WZWZCULESA-N 50540861 EFT-226::Eft226::Zotatifin Eukaryotic initiation factor 4A-I Homo sapiens 92 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138801 442142424 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51336311 COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 QYCXWOACFWMQFO-WZWZCULESA-N 50540861 EFT-226::Eft226::Zotatifin Eukaryotic initiation factor 4A-I Homo sapiens 218 ChEMBL 10.1021/acs.jmedchem.0c00182 10.7270/Q2MC93K8 32470302 Ernst, JT; Thompson, PA; Nilewski, C; Sprengeler, PA; Sperry, S; Packard, G; Michels, T; Xiang, A; Tran, C; Wegerski, CJ; Eam, B; Young, NP; Fish, S; Chen, J; Howard, H; Staunton, J; Molter, J; Clarine, J; Nevarez, A; Chiang, GG; Appleman, JR; Webster, KR; Reich, SH Inception Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50540861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50540861&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138801 442142424 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427547 COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C25H23N3O3/c1-30-21-14-28-15-22-23(21)24(29)19(13-27)11-20(17-5-3-2-4-6-17)25(24,31-22)18-9-7-16(12-26)8-10-18/h2-10,14-15,19-20,29H,11,13,27H2,1H3/t19-,20+,24-,25+/m1/s1 ZODGQNOIBMPUAB-GRADPPADSA-N 50576669 CHEMBL4855528 Eukaryotic initiation factor 4A-I Homo sapiens 5.6 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576669&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138983 471052792 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427548 COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 InChI=1S/C24H23BrN2O3/c1-29-20-13-27-14-21-22(20)23(28)17(12-26)11-19(15-5-3-2-4-6-15)24(23,30-21)16-7-9-18(25)10-8-16/h2-10,13-14,17,19,28H,11-12,26H2,1H3/t17-,19+,23-,24+/m1/s1 RWBSCQLDBFWJGG-KAOJSAQUSA-N 50576670 CHEMBL4864162 Eukaryotic initiation factor 4A-I Homo sapiens 5.0 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576670&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138601 471052793 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427549 COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 InChI=1S/C25H25BrN2O4/c1-31-20-12-28-13-21-23(20)24(30)19(11-27)18(14-29)22(15-5-3-2-4-6-15)25(24,32-21)16-7-9-17(26)10-8-16/h2-10,12-13,18-19,22,29-30H,11,14,27H2,1H3/t18-,19-,22+,24+,25-/m0/s1 KDWZKFZPGWZUHU-UPIYQZMDSA-N 50576671 CHEMBL4875109 Eukaryotic initiation factor 4A-I Homo sapiens 25 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576671&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138871 471052794 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427550 COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CNC4COC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 InChI=1S/C28H29BrN2O5/c1-34-23-12-30-13-24-26(23)27(33)22(11-31-20-15-35-16-20)21(14-32)25(17-5-3-2-4-6-17)28(27,36-24)18-7-9-19(29)10-8-18/h2-10,12-13,20-22,25,31-33H,11,14-16H2,1H3/t21-,22-,25+,27+,28-/m0/s1 XEZAMGVLOVUUBG-MSRUBZGQSA-N 50576672 CHEMBL4857096 Eukaryotic initiation factor 4A-I Homo sapiens 2.3 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576672&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129139069 471052795 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427551 COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CN4CCOCC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 InChI=1S/C29H31BrN2O5/c1-35-24-15-31-16-25-27(24)28(34)23(17-32-11-13-36-14-12-32)22(18-33)26(19-5-3-2-4-6-19)29(28,37-25)20-7-9-21(30)10-8-20/h2-10,15-16,22-23,26,33-34H,11-14,17-18H2,1H3/t22-,23-,26+,28+,29-/m0/s1 IFRZKYZIXROIRF-PUOQHSKASA-N 50576673 CHEMBL4849769 Eukaryotic initiation factor 4A-I Homo sapiens 10.0 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576673&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138986 471052796 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427552 COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(cc1)C#N InChI=1S/C25H23N3O3/c1-30-21-14-28-15-22-23(21)24(29)19(13-27)11-20(17-5-3-2-4-6-17)25(24,31-22)18-9-7-16(12-26)8-10-18/h2-10,14-15,19-20,29H,11,13,27H2,1H3/t19-,20+,24-,25+/m1/s1 ZODGQNOIBMPUAB-GRADPPADSA-N 50576669 CHEMBL4855528 Eukaryotic initiation factor 4A-I Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576669&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138983 471052792 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427553 COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 InChI=1S/C24H23BrN2O3/c1-29-20-13-27-14-21-22(20)23(28)17(12-26)11-19(15-5-3-2-4-6-15)24(23,30-21)16-7-9-18(25)10-8-16/h2-10,13-14,17,19,28H,11-12,26H2,1H3/t17-,19+,23-,24+/m1/s1 RWBSCQLDBFWJGG-KAOJSAQUSA-N 50576670 CHEMBL4864162 Eukaryotic initiation factor 4A-I Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576670&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138601 471052793 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427554 COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 InChI=1S/C25H25BrN2O4/c1-31-20-12-28-13-21-23(20)24(30)19(11-27)18(14-29)22(15-5-3-2-4-6-15)25(24,32-21)16-7-9-17(26)10-8-16/h2-10,12-13,18-19,22,29-30H,11,14,27H2,1H3/t18-,19-,22+,24+,25-/m0/s1 KDWZKFZPGWZUHU-UPIYQZMDSA-N 50576671 CHEMBL4875109 Eukaryotic initiation factor 4A-I Homo sapiens 89 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576671&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138871 471052794 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427555 COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CNC4COC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 InChI=1S/C28H29BrN2O5/c1-34-23-12-30-13-24-26(23)27(33)22(11-31-20-15-35-16-20)21(14-32)25(17-5-3-2-4-6-17)28(27,36-24)18-7-9-19(29)10-8-18/h2-10,12-13,20-22,25,31-33H,11,14-16H2,1H3/t21-,22-,25+,27+,28-/m0/s1 XEZAMGVLOVUUBG-MSRUBZGQSA-N 50576672 CHEMBL4857096 Eukaryotic initiation factor 4A-I Homo sapiens 11 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576672&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129139069 471052795 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51427556 COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CN4CCOCC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 InChI=1S/C29H31BrN2O5/c1-35-24-15-31-16-25-27(24)28(34)23(17-32-11-13-36-14-12-32)22(18-33)26(19-5-3-2-4-6-19)29(28,37-25)20-7-9-21(30)10-8-20/h2-10,15-16,22-23,26,33-34H,11-14,17-18H2,1H3/t22-,23-,26+,28+,29-/m0/s1 IFRZKYZIXROIRF-PUOQHSKASA-N 50576673 CHEMBL4849769 Eukaryotic initiation factor 4A-I Homo sapiens 32 ChEMBL 10.1016/j.bmcl.2021.128111 10.7270/Q2GQ72K9 34353608 Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH eFFECTOR Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576673&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 129138986 471052796 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517929 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(Br)ccc2n1 InChI=1S/C24H20BrNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-13-17(25)9-10-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) QXOMZRAYIBZPJH-UHFFFAOYSA-N 50610942 CHEMBL5267864 Eukaryotic initiation factor 4A-I Homo sapiens 26590 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610942&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 1578256 494500690 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517930 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(=O)OCC)c2cc(Br)ccc2n1 InChI=1S/C26H24BrNO3/c1-3-5-6-17-7-9-18(10-8-17)24-13-14-25(31-24)23-16-21(26(29)30-4-2)20-15-19(27)11-12-22(20)28-23/h7-16H,3-6H2,1-2H3 VVXBDWBAVBYTEN-UHFFFAOYSA-N 50610943 CHEMBL5268921 Eukaryotic initiation factor 4A-I Homo sapiens 129100 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610943&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502280 494500691 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517931 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2ccccc2n1 InChI=1S/C24H21NO3/c1-2-3-6-16-9-11-17(12-10-16)22-13-14-23(28-22)21-15-19(24(26)27)18-7-4-5-8-20(18)25-21/h4-5,7-15H,2-3,6H2,1H3,(H,26,27) JZOHDMAORHFDPG-UHFFFAOYSA-N 50610944 CHEMBL5288848 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610944&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 1578196 494500692 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517932 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2c(Cl)cccc2n1 InChI=1S/C24H20ClNO3/c1-2-3-5-15-8-10-16(11-9-15)21-12-13-22(29-21)20-14-17(24(27)28)23-18(25)6-4-7-19(23)26-20/h4,6-14H,2-3,5H2,1H3,(H,27,28) ASGUZTVMKFPNHS-UHFFFAOYSA-N 50610945 CHEMBL5279233 Eukaryotic initiation factor 4A-I Homo sapiens 135400 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610945&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502290 494500693 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517933 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(F)ccc2n1 InChI=1S/C24H20FNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-13-17(25)9-10-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) VLHYMZJIZXMXCJ-UHFFFAOYSA-N 50610946 CHEMBL5286598 Eukaryotic initiation factor 4A-I Homo sapiens 54120 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610946&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502265 494500694 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517934 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(Cl)ccc2n1 InChI=1S/C24H20ClNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-13-17(25)9-10-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) BITXTSFDCTVZRN-UHFFFAOYSA-N 50610947 CHEMBL5273891 Eukaryotic initiation factor 4A-I Homo sapiens 44020 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610947&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 1578238 494500695 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517935 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(I)ccc2n1 InChI=1S/C24H20INO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-13-17(25)9-10-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) UCAMPIXJJOIHBI-UHFFFAOYSA-N 50610948 CHEMBL5269672 Eukaryotic initiation factor 4A-I Homo sapiens 41510 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610948&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502282 494500696 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517936 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2ccc(F)cc2n1 InChI=1S/C24H20FNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-10-9-17(25)13-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) CJQNLSAPOWNBJF-UHFFFAOYSA-N 50610949 CHEMBL5282106 Eukaryotic initiation factor 4A-I Homo sapiens 46550 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610949&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502273 494500697 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517937 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2ccc(Cl)cc2n1 InChI=1S/C24H20ClNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-10-9-17(25)13-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) OPELUULXKNWHIH-UHFFFAOYSA-N 50610950 CHEMBL5277447 Eukaryotic initiation factor 4A-I Homo sapiens 21650 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610950&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502295 494500698 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517938 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2ccc(Br)cc2n1 InChI=1S/C24H20BrNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-10-9-17(25)13-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) OTYJLDVCNHBIKU-UHFFFAOYSA-N 50610951 CHEMBL5270826 Eukaryotic initiation factor 4A-I Homo sapiens 33030 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610951&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502270 494500699 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517939 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cccc(Cl)c2n1 InChI=1S/C24H20ClNO3/c1-2-3-5-15-8-10-16(11-9-15)21-12-13-22(29-21)20-14-18(24(27)28)17-6-4-7-19(25)23(17)26-20/h4,6-14H,2-3,5H2,1H3,(H,27,28) CXNOQMPQAQHAEQ-UHFFFAOYSA-N 50610952 CHEMBL5270012 Eukaryotic initiation factor 4A-I Homo sapiens 73350 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610952&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502266 494500700 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517940 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cccc(Br)c2n1 InChI=1S/C24H20BrNO3/c1-2-3-5-15-8-10-16(11-9-15)21-12-13-22(29-21)20-14-18(24(27)28)17-6-4-7-19(25)23(17)26-20/h4,6-14H,2-3,5H2,1H3,(H,27,28) LJROGPGERUXVSC-UHFFFAOYSA-N 50610953 CHEMBL5271469 Eukaryotic initiation factor 4A-I Homo sapiens 23760 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610953&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502289 494500701 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517941 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(F)c(F)cc2n1 InChI=1S/C24H19F2NO3/c1-2-3-4-14-5-7-15(8-6-14)22-9-10-23(30-22)21-12-17(24(28)29)16-11-18(25)19(26)13-20(16)27-21/h5-13H,2-4H2,1H3,(H,28,29) VCYGJCFDLVPRGA-UHFFFAOYSA-N 50610954 CHEMBL5281779 Eukaryotic initiation factor 4A-I Homo sapiens 53980 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610954&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502253 494500702 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517942 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(Cl)c(Cl)cc2n1 InChI=1S/C24H19Cl2NO3/c1-2-3-4-14-5-7-15(8-6-14)22-9-10-23(30-22)21-12-17(24(28)29)16-11-18(25)19(26)13-20(16)27-21/h5-13H,2-4H2,1H3,(H,28,29) VFIALJKHHJDTGC-UHFFFAOYSA-N 50610955 CHEMBL5279031 Eukaryotic initiation factor 4A-I Homo sapiens 90060 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610955&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502251 494500703 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517943 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(F)cc(F)c2n1 InChI=1S/C24H19F2NO3/c1-2-3-4-14-5-7-15(8-6-14)21-9-10-22(30-21)20-13-18(24(28)29)17-11-16(25)12-19(26)23(17)27-20/h5-13H,2-4H2,1H3,(H,28,29) ITCJZZINPXVJGC-UHFFFAOYSA-N 50610956 CHEMBL5291302 Eukaryotic initiation factor 4A-I Homo sapiens 52130 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610956&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171351902 494500704 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517944 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(C)ccc2n1 InChI=1S/C25H23NO3/c1-3-4-5-17-7-9-18(10-8-17)23-12-13-24(29-23)22-15-20(25(27)28)19-14-16(2)6-11-21(19)26-22/h6-15H,3-5H2,1-2H3,(H,27,28) XNIDROUAJHVKBT-UHFFFAOYSA-N 50610957 CHEMBL5278691 Eukaryotic initiation factor 4A-I Homo sapiens 105100 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610957&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 1578209 494500705 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517945 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(CC)ccc2n1 InChI=1S/C26H25NO3/c1-3-5-6-18-7-10-19(11-8-18)24-13-14-25(30-24)23-16-21(26(28)29)20-15-17(4-2)9-12-22(20)27-23/h7-16H,3-6H2,1-2H3,(H,28,29) QWHQWCUIFBVRFH-UHFFFAOYSA-N 50610958 CHEMBL5275191 Eukaryotic initiation factor 4A-I Homo sapiens 146600 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610958&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502276 494500706 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517946 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)C(C)C InChI=1S/C27H27NO3/c1-4-5-6-18-7-9-19(10-8-18)25-13-14-26(31-25)24-16-22(27(29)30)21-15-20(17(2)3)11-12-23(21)28-24/h7-17H,4-6H2,1-3H3,(H,29,30) GGZQUIDRJJKRMS-UHFFFAOYSA-N 50610959 CHEMBL5267465 Eukaryotic initiation factor 4A-I Homo sapiens 107300 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610959&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502264 494500707 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517947 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)-c1ccccc1 InChI=1S/C30H25NO3/c1-2-3-7-20-10-12-22(13-11-20)28-16-17-29(34-28)27-19-25(30(32)33)24-18-23(14-15-26(24)31-27)21-8-5-4-6-9-21/h4-6,8-19H,2-3,7H2,1H3,(H,32,33) RXOXAYKOPQAIOP-UHFFFAOYSA-N 50610960 CHEMBL5286022 Eukaryotic initiation factor 4A-I Homo sapiens 124300 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610960&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502257 494500708 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517948 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(C)cc(C)c2n1 InChI=1S/C26H25NO3/c1-4-5-6-18-7-9-19(10-8-18)23-11-12-24(30-23)22-15-21(26(28)29)20-14-16(2)13-17(3)25(20)27-22/h7-15H,4-6H2,1-3H3,(H,28,29) GIQZSONCIIWZCJ-UHFFFAOYSA-N 50610961 CHEMBL5279624 Eukaryotic initiation factor 4A-I Homo sapiens 111300 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610961&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502269 494500709 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517949 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(OC)ccc2n1 InChI=1S/C25H23NO4/c1-3-4-5-16-6-8-17(9-7-16)23-12-13-24(30-23)22-15-20(25(27)28)19-14-18(29-2)10-11-21(19)26-22/h6-15H,3-5H2,1-2H3,(H,27,28) RDZXVUBKWQDIHN-UHFFFAOYSA-N 50610962 CHEMBL5282161 Eukaryotic initiation factor 4A-I Homo sapiens 53520 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610962&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502288 494500710 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517950 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2ccc(C)cc2n1 InChI=1S/C25H23NO3/c1-3-4-5-17-7-9-18(10-8-17)23-12-13-24(29-23)22-15-20(25(27)28)19-11-6-16(2)14-21(19)26-22/h6-15H,3-5H2,1-2H3,(H,27,28) OJDZADYTGGPABT-UHFFFAOYSA-N 50610963 CHEMBL5278060 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610963&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171355244 494500711 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517951 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(OC(F)(F)F)ccc2n1 InChI=1S/C25H20F3NO4/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(32-22)21-14-19(24(30)31)18-13-17(33-25(26,27)28)9-10-20(18)29-21/h5-14H,2-4H2,1H3,(H,30,31) MVFYMWKLYJMNSH-UHFFFAOYSA-N 50610964 CHEMBL5267330 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610964&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502296 494500712 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517952 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(N)ccc2n1 InChI=1S/C24H22N2O3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-13-17(25)9-10-20(18)26-21/h5-14H,2-4,25H2,1H3,(H,27,28) AJUNBAYYKUJCRM-UHFFFAOYSA-N 50610965 CHEMBL5277718 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610965&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502260 494500713 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517953 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(NC(C)=O)ccc2n1 InChI=1S/C26H24N2O4/c1-3-4-5-17-6-8-18(9-7-17)24-12-13-25(32-24)23-15-21(26(30)31)20-14-19(27-16(2)29)10-11-22(20)28-23/h6-15H,3-5H2,1-2H3,(H,27,29)(H,30,31) SJRRHZDEYJTGMX-UHFFFAOYSA-N 50610966 CHEMBL5287256 Eukaryotic initiation factor 4A-I Homo sapiens 125800 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610966&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502291 494500714 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517954 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2ccc(cc2n1)C(F)(F)F InChI=1S/C25H20F3NO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(32-22)21-14-19(24(30)31)18-10-9-17(25(26,27)28)13-20(18)29-21/h5-14H,2-4H2,1H3,(H,30,31) LXKCGLYRLHPZLY-UHFFFAOYSA-N 50610967 CHEMBL5274512 Eukaryotic initiation factor 4A-I Homo sapiens 61030 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610967&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502278 494500715 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517955 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cccc(c2n1)C(F)(F)F InChI=1S/C25H20F3NO3/c1-2-3-5-15-8-10-16(11-9-15)21-12-13-22(32-21)20-14-18(24(30)31)17-6-4-7-19(23(17)29-20)25(26,27)28/h4,6-14H,2-3,5H2,1H3,(H,30,31) TYBYECRISUJZJE-UHFFFAOYSA-N 50610968 CHEMBL5278017 Eukaryotic initiation factor 4A-I Homo sapiens 26860 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610968&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502259 494500716 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517956 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens 8603 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517957 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(=O)OCC)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C26H24N2O5/c1-3-5-6-17-7-9-18(10-8-17)24-13-14-25(33-24)23-16-21(26(29)32-4-2)20-15-19(28(30)31)11-12-22(20)27-23/h7-16H,3-6H2,1-2H3 IRXVLIDGUFWEHS-UHFFFAOYSA-N 50610970 CHEMBL5276103 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610970&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502292 494500718 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517958 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cccc([N+]([O-])=O)c2n1 InChI=1S/C24H20N2O5/c1-2-3-5-15-8-10-16(11-9-15)21-12-13-22(31-21)19-14-18(24(27)28)17-6-4-7-20(26(29)30)23(17)25-19/h4,6-14H,2-3,5H2,1H3,(H,27,28) UYYDLYQWGCHBHX-UHFFFAOYSA-N 50610971 CHEMBL5290937 Eukaryotic initiation factor 4A-I Homo sapiens 27460 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610971&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502286 494500719 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517959 CCCCc1ccc(cc1)-c1ccc(s1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O4S/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) DUJKDMQCPZSCEK-UHFFFAOYSA-N 50610972 CHEMBL5284445 Eukaryotic initiation factor 4A-I Homo sapiens 62260 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610972&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502252 494500720 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517960 CCCCc1ccc(cc1)-c1ccc([nH]1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H21N3O4/c1-2-3-4-15-5-7-16(8-6-15)20-11-12-22(25-20)23-14-19(24(28)29)18-13-17(27(30)31)9-10-21(18)26-23/h5-14,25H,2-4H2,1H3,(H,28,29) JYDTUYVUVDEFQE-UHFFFAOYSA-N 50610973 CHEMBL5291093 Eukaryotic initiation factor 4A-I Homo sapiens 62510 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610973&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171351803 494500721 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517961 CCCCc1ccc(cc1)-c1cccc(c1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C26H22N2O4/c1-2-3-5-17-8-10-18(11-9-17)19-6-4-7-20(14-19)25-16-23(26(29)30)22-15-21(28(31)32)12-13-24(22)27-25/h4,6-16H,2-3,5H2,1H3,(H,29,30) GVFGZNGTYHTHRY-UHFFFAOYSA-N 50610974 CHEMBL5274599 Eukaryotic initiation factor 4A-I Homo sapiens 74090 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610974&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171356159 494500722 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517962 CCCCc1ccc(cc1)-c1cccc(n1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C25H21N3O4/c1-2-3-5-16-8-10-17(11-9-16)21-6-4-7-23(26-21)24-15-20(25(29)30)19-14-18(28(31)32)12-13-22(19)27-24/h4,6-15H,2-3,5H2,1H3,(H,29,30) NCNMBTPGFYQDPF-UHFFFAOYSA-N 50610975 CHEMBL5275373 Eukaryotic initiation factor 4A-I Homo sapiens 85750 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610975&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502293 494500723 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517963 CCCCc1ccc(cc1)-c1cncc(c1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C25H21N3O4/c1-2-3-4-16-5-7-17(8-6-16)18-11-19(15-26-14-18)24-13-22(25(29)30)21-12-20(28(31)32)9-10-23(21)27-24/h5-15H,2-4H2,1H3,(H,29,30) LVRYTRRFGLPRIO-UHFFFAOYSA-N 50610976 CHEMBL5270572 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610976&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502283 494500724 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517964 CCCCc1ccc(cc1)-c1ccc(cc1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C26H22N2O4/c1-2-3-4-17-5-7-18(8-6-17)19-9-11-20(12-10-19)25-16-23(26(29)30)22-15-21(28(31)32)13-14-24(22)27-25/h5-16H,2-4H2,1H3,(H,29,30) JSXHRLFVMGNWSS-UHFFFAOYSA-N 50610977 CHEMBL5278064 Eukaryotic initiation factor 4A-I Homo sapiens 54780 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610977&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171355571 494500725 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517965 CCCCc1ccc(cc1)-c1ccc(cn1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C25H21N3O4/c1-2-3-4-16-5-7-17(8-6-16)22-11-9-18(15-26-22)24-14-21(25(29)30)20-13-19(28(31)32)10-12-23(20)27-24/h5-15H,2-4H2,1H3,(H,29,30) AFRROEQBTYBDGI-UHFFFAOYSA-N 50610978 CHEMBL5274646 Eukaryotic initiation factor 4A-I Homo sapiens 59990 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610978&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502258 494500726 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517966 OC(=O)c1cc(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(o1)-c1ccccc1 InChI=1S/C20H12N2O5/c23-20(24)15-11-17(21-16-7-6-13(22(25)26)10-14(15)16)19-9-8-18(27-19)12-4-2-1-3-5-12/h1-11H,(H,23,24) LMJMPZKPESJPHT-UHFFFAOYSA-N 50610979 CHEMBL5281123 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610979&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502263 494500727 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517967 CCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C23H18N2O5/c1-2-3-14-4-6-15(7-5-14)21-10-11-22(30-21)20-13-18(23(26)27)17-12-16(25(28)29)8-9-19(17)24-20/h4-13H,2-3H2,1H3,(H,26,27) AYLJQQXWEMDPLJ-UHFFFAOYSA-N 50610980 CHEMBL5288236 Eukaryotic initiation factor 4A-I Homo sapiens 40940 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610980&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502271 494500728 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517968 CCCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C25H22N2O5/c1-2-3-4-5-16-6-8-17(9-7-16)23-12-13-24(32-23)22-15-20(25(28)29)19-14-18(27(30)31)10-11-21(19)26-22/h6-15H,2-5H2,1H3,(H,28,29) RHZGJPMVQVMFDY-UHFFFAOYSA-N 50610981 CHEMBL5275207 Eukaryotic initiation factor 4A-I Homo sapiens 8770 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610981&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502256 494500729 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517969 CCCOc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C23H18N2O6/c1-2-11-30-16-6-3-14(4-7-16)21-9-10-22(31-21)20-13-18(23(26)27)17-12-15(25(28)29)5-8-19(17)24-20/h3-10,12-13H,2,11H2,1H3,(H,26,27) OPKIDFNJSOPFQW-UHFFFAOYSA-N 50610982 CHEMBL5275434 Eukaryotic initiation factor 4A-I Homo sapiens 45720 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610982&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502268 494500730 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517970 CCCOc1cccc(c1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C23H18N2O6/c1-2-10-30-16-5-3-4-14(11-16)21-8-9-22(31-21)20-13-18(23(26)27)17-12-15(25(28)29)6-7-19(17)24-20/h3-9,11-13H,2,10H2,1H3,(H,26,27) XWSFJFZPMUTWGP-UHFFFAOYSA-N 50610983 CHEMBL5274106 Eukaryotic initiation factor 4A-I Homo sapiens 62050 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610983&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502294 494500731 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517971 CCCOc1ccccc1-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C23H18N2O6/c1-2-11-30-20-6-4-3-5-15(20)21-9-10-22(31-21)19-13-17(23(26)27)16-12-14(25(28)29)7-8-18(16)24-19/h3-10,12-13H,2,11H2,1H3,(H,26,27) SMNNWUCOYQBHKS-UHFFFAOYSA-N 50610984 CHEMBL5281120 Eukaryotic initiation factor 4A-I Homo sapiens 45460 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610984&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502284 494500732 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517972 CC(C)(C)OC(=O)Nc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C25H21N3O7/c1-25(2,3)35-24(31)26-15-6-4-14(5-7-15)21-10-11-22(34-21)20-13-18(23(29)30)17-12-16(28(32)33)8-9-19(17)27-20/h4-13H,1-3H3,(H,26,31)(H,29,30) BUBVDVJTQVETDX-UHFFFAOYSA-N 50610985 CHEMBL5290956 Eukaryotic initiation factor 4A-I Homo sapiens 140200 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610985&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171358901 494500733 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517973 CC(C)(C)OC(=O)Nc1cccc(c1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C25H21N3O7/c1-25(2,3)35-24(31)26-15-6-4-5-14(11-15)21-9-10-22(34-21)20-13-18(23(29)30)17-12-16(28(32)33)7-8-19(17)27-20/h4-13H,1-3H3,(H,26,31)(H,29,30) MAFQWMARXPTHSI-UHFFFAOYSA-N 50610986 CHEMBL5283936 Eukaryotic initiation factor 4A-I Homo sapiens 110300 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610986&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171345600 494500734 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517974 Nc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C20H13N3O5/c21-12-3-1-11(2-4-12)18-7-8-19(28-18)17-10-15(20(24)25)14-9-13(23(26)27)5-6-16(14)22-17/h1-10H,21H2,(H,24,25) RXSMZXPDTZJRDR-UHFFFAOYSA-N 50610987 CHEMBL5283562 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610987&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502255 494500735 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517975 Nc1cccc(c1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C20H13N3O5/c21-12-3-1-2-11(8-12)18-6-7-19(28-18)17-10-15(20(24)25)14-9-13(23(26)27)4-5-16(14)22-17/h1-10H,21H2,(H,24,25) ZMTMFWBBSCMDOU-UHFFFAOYSA-N 50610988 CHEMBL5288219 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610988&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502277 494500736 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517976 OC(=O)c1cc(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(o1)-c1ccc2OCOc2c1 InChI=1S/C21H12N2O7/c24-21(25)14-9-16(22-15-3-2-12(23(26)27)8-13(14)15)18-6-5-17(30-18)11-1-4-19-20(7-11)29-10-28-19/h1-9H,10H2,(H,24,25) AXLIAKNHAZHVJI-UHFFFAOYSA-N 50610989 CHEMBL5276645 Eukaryotic initiation factor 4A-I Homo sapiens >150000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610989&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171357316 494500737 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517977 OC(=O)c1cc(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(o1)-c1cccc2ccccc12 InChI=1S/C24H14N2O5/c27-24(28)19-13-21(25-20-9-8-15(26(29)30)12-18(19)20)23-11-10-22(31-23)17-7-3-5-14-4-1-2-6-16(14)17/h1-13H,(H,27,28) BSWSFCALIUTWFM-UHFFFAOYSA-N 50610990 CHEMBL5278278 Eukaryotic initiation factor 4A-I Homo sapiens 36720 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610990&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502287 494500738 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517978 OC(=O)c1cc(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(o1)-c1ccc(cc1)-c1ccccc1 InChI=1S/C26H16N2O5/c29-26(30)21-15-23(27-22-11-10-19(28(31)32)14-20(21)22)25-13-12-24(33-25)18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-15H,(H,29,30) XZCADTFWPABVLV-UHFFFAOYSA-N 50610991 CHEMBL5286924 Eukaryotic initiation factor 4A-I Homo sapiens 66100 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610991&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171345421 494500739 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517979 OC(=O)c1cc(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(o1)-c1cccc(c1)-c1ccccc1 InChI=1S/C26H16N2O5/c29-26(30)21-15-23(27-22-10-9-19(28(31)32)14-20(21)22)25-12-11-24(33-25)18-8-4-7-17(13-18)16-5-2-1-3-6-16/h1-15H,(H,29,30) ZIXBULKLVGZUNO-UHFFFAOYSA-N 50610992 CHEMBL5270689 Eukaryotic initiation factor 4A-I Homo sapiens 25760 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610992&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 171343233 494500740 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517980 OC(=O)c1cc(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(o1)-c1ccc(Oc2ccccc2)cc1 InChI=1S/C26H16N2O6/c29-26(30)21-15-23(27-22-11-8-17(28(31)32)14-20(21)22)25-13-12-24(34-25)16-6-9-19(10-7-16)33-18-4-2-1-3-5-18/h1-15H,(H,29,30) OTHFCLLKVCBBOL-UHFFFAOYSA-N 50610993 CHEMBL5285027 Eukaryotic initiation factor 4A-I Homo sapiens 12710 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610993&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502261 494500741 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517981 OC(=O)c1cc(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(o1)-c1cccc(Oc2ccccc2)c1 InChI=1S/C26H16N2O6/c29-26(30)21-15-23(27-22-10-9-17(28(31)32)14-20(21)22)25-12-11-24(34-25)16-5-4-8-19(13-16)33-18-6-2-1-3-7-18/h1-15H,(H,29,30) JMJJLSXDXWMAQS-UHFFFAOYSA-N 50610994 CHEMBL5286197 Eukaryotic initiation factor 4A-I Homo sapiens 22220 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610994&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502254 494500742 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517982 OC(=O)c1cc(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(o1)-c1ccccc1Oc1ccccc1 InChI=1S/C26H16N2O6/c29-26(30)20-15-22(27-21-11-10-16(28(31)32)14-19(20)21)25-13-12-24(34-25)18-8-4-5-9-23(18)33-17-6-2-1-3-7-17/h1-15H,(H,29,30) AWNCENDLAUNLLJ-UHFFFAOYSA-N 50610995 CHEMBL5283331 Eukaryotic initiation factor 4A-I Homo sapiens 20990 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610995&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 167502274 494500743 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517983 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(Br)ccc2n1 InChI=1S/C24H20BrNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-13-17(25)9-10-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) QXOMZRAYIBZPJH-UHFFFAOYSA-N 50610942 CHEMBL5267864 Eukaryotic initiation factor 4A-I Homo sapiens 10300 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610942&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 1578256 494500690 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517984 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens 4790 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517985 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(Br)ccc2n1 InChI=1S/C24H20BrNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-13-17(25)9-10-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) QXOMZRAYIBZPJH-UHFFFAOYSA-N 50610942 CHEMBL5267864 Eukaryotic initiation factor 4A-I Homo sapiens 9590 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610942&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 1578256 494500690 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517986 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens 4270 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517987 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens >50000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517988 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens >50000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517989 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens >50000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517990 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens >50000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517991 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens >50000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517992 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens >50000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517993 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens >50000 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517994 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(Br)ccc2n1 InChI=1S/C24H20BrNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-13-17(25)9-10-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) QXOMZRAYIBZPJH-UHFFFAOYSA-N 50610942 CHEMBL5267864 Eukaryotic initiation factor 4A-I Homo sapiens 160600 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610942&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 1578256 494500690 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517995 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens 58300 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517996 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(Br)ccc2n1 InChI=1S/C24H20BrNO3/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(29-22)21-14-19(24(27)28)18-13-17(25)9-10-20(18)26-21/h5-14H,2-4H2,1H3,(H,27,28) QXOMZRAYIBZPJH-UHFFFAOYSA-N 50610942 CHEMBL5267864 Eukaryotic initiation factor 4A-I Homo sapiens 28700 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610942&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 1578256 494500690 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516 51517997 CCCCc1ccc(cc1)-c1ccc(o1)-c1cc(C(O)=O)c2cc(ccc2n1)[N+]([O-])=O InChI=1S/C24H20N2O5/c1-2-3-4-15-5-7-16(8-6-15)22-11-12-23(31-22)21-14-19(24(27)28)18-13-17(26(29)30)9-10-20(18)25-21/h5-14H,2-4H2,1H3,(H,27,28) UDCAKLDMNJRQKW-UHFFFAOYSA-N 50610969 CHEMBL5278302 Eukaryotic initiation factor 4A-I Homo sapiens 6580 ChEMBL 10.7270/Q22J6H3K 34676755 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50610969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50006095&target=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50610969&enzyme=Eukaryotic+initiation+factor+4A-I&column=ki&startPg=0&Increment=50&submit=Search 163198549 494500717 1 MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI 2G9N,2ZU6,3EIQ,5ZBZ,6XKI,6ZMW,7DDX,7PPZ,7PQ0,8HUJ Eukaryotic initiation factor 4A-I IF4A1_HUMAN P60842 B2R6L8 D3DTP9 J3QLC4 P04765 Q5U018 Q61516