BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 66844 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 260 PubChem 10.7270/Q2XW4H6C aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 66845 CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ WVUNYSQLFKLYNI-AATRIKPKSA-N 31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 2600 PubChem 10.7270/Q2XW4H6C aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 93J 7AXM,5VCW 6445562 252615337 38927 ZINC00602803 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 66846 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 1300 PubChem 10.7270/Q2XW4H6C aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 66847 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 830 PubChem 10.7270/Q2XW4H6C aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 66848 CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m0/s1 BMGQWWVMWDBQGC-PZFYLCKJSA-N 31094 PKC-412::cid_24202429 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 270 PubChem 10.7270/Q2XW4H6C aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31094&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 24202429 242052840 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 66849 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 260 PubChem 10.7270/Q2XW4H6C aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 66850 CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1 HKSZLNNOFSGOKW-HMWZOHBLSA-N 31096 CHEMBL290084::Staurosporine::cid_451705 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 77 PubChem 10.7270/Q2XW4H6C aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31096&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 451705 242052841 CHEMBL290084 346 ZINC05615681 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 66851 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 39 PubChem 10.7270/Q2XW4H6C aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 66852 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 140 PubChem 10.7270/Q2XW4H6C aid1433 PubChem, PC Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50165455 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 18 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50165831 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 270 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50184807 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 77 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50185215 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 270 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50182415 C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4C(=O)NCc4c4c5ccccc5n2c4c13 InChI=1S/C26H21N3O4/c1-25-26(32,12-30)10-18(33-25)28-16-8-4-2-6-13(16)20-21-15(11-27-24(21)31)19-14-7-3-5-9-17(14)29(25)23(19)22(20)28/h2-9,18,30,32H,10-12H2,1H3,(H,27,31)/t18-,25+,26+/m1/s1 UIARLYUEJFELEN-LROUJFHJSA-N 50308060 16-hydroxy-16-(hydroxymethyl)-15-methyl-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]octacosa-1(26),2(6),7(27),8(13),9,11,20(25),21,23-nonaen-3-one::CEP-701::CHEMBL603469::US11370779, Compound CEP-701 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 18 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50308060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50308060&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 2V9 5WNJ,4OTG 126565 104162421 CHEMBL603469 5672 ZINC03781738 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50195736 COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1 InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- XZXHXSATPCNXJR-ZIADKAODSA-N 50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 17 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026612&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search XIN 5MAF,6NEC,3C7Q,5TE0 9809715 277286638 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50227867 CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 2579 (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::CHEMBL388978::Staurosporin, 4::Staurosporine::Staurosporine, 8::US9206188, Staurosporine::US9226923, Staurosporine Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 77 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=2579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=2579&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search STO 1AQ1,1BYG,1E8Z,1NVR,1NXK,1OKY,1Q3D,1QPD,1QPJ,1SM2,1SNU,1STC,1U59,1WVY,1XBC,1XJD,1YHS,2BUJ,2CLQ,2DQ7,2GCD,2HW7,2ITQ,2ITU,2ITW,2NRY,2OIC 44259 8032349 15738 CHEMBL388978 346 C02079 ZINC03814434 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50230409 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 270 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50595686 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50595954 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50594811 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50595233 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 39 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50596816 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O5/c1-35-31(43-3)23(37(2)34(42)18-11-5-4-6-12-18)17-24(44-35)38-21-15-9-7-13-19(21)25-27-28(33(41)36-32(27)40)26-20-14-8-10-16-22(20)39(35)30(26)29(25)38/h4-16,23-24,31,33,41H,17H2,1-3H3,(H,36,40)/t23-,24-,31-,33+,35+/m1/s1 ZZSBPGIGIUFJRA-AKIDMACVSA-N 50326054 CHEMBL1240703 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 3200 ChEMBL 10.1182/blood-2009-05-222034 10.7270/Q2PN95V2 19654408 Zarrinkar, PP; Gunawardane, RN; Cramer, MD; Gardner, MF; Brigham, D; Belli, B; Karaman, MW; Pratz, KW; Pallares, G; Chao, Q; Sprankle, KG; Patel, HK; Levis, M; Armstrong, RC; James, J; Bhagwat, SS Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326054&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 52945601 123105169 CHEMBL1240703 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50669591 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50667097 COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) UBPYILGKFZZVDX-UHFFFAOYSA-N 4552 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile::BOSUTINIB::CHEMBL288441::SKI-606 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4552&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search DB8 6OP9,5AJQ,4MXO,4MXY,4MXX,4MXZ,3SOA,5VC3,6FDY,5I9X,3UE4,4QMN,5VCY 5328940 8034215 39112 CHEMBL288441 DB06616 5710 ZINC22448983 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50668493 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50667246 COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1 InChI=1S/C24H24N4O5S/c1-14(23-26-9-10-34-23)27-24(29)28-17-6-5-15(11-20(17)30-2)33-19-7-8-25-18-13-22(32-4)21(31-3)12-16(18)19/h5-14H,1-4H3,(H2,27,28,29) SHPFDGWALWEPGS-UHFFFAOYSA-N 50355494 CHEMBL1908396 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355494&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 9869779 136959518 CHEMBL1908396 ZINC13975055 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50667308 Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1 InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1 BPNUQXPIQBZCMR-IBGZPJMESA-N 15138 5-indazolyl pyridine 11g::5-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-3-methyl-1H-indazole::A-674563::Biochemistry 469551 Compound 11::indazole-pyridine, 7 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 1700 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15138&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search SS3 2UZT 11314340 46515449 DB08568 5655 ZINC16052569 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50668640 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50668681 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50666053 CNC(=O)c1ccccc1Sc1ccc2c(\C=C\c3ccccn3)n[nH]c2c1 InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ RITAVMQDGBJQJZ-FMIVXFBMSA-N 25117 AG-013736::AXITINIB::N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide::US10464902, Axitinib::US9205078, Axitinib ::US9617222, Compound A Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25117&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 6450551 56374259 66910 5659 ZINC03816287 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50668769 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 830 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50681012 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50688223 Cn1cc(C2=C(C(=O)NC2=O)c2cn(C3CCN(Cc4ccccn4)CC3)c3ccccc23)c2ccccc12 InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39) AXRCEOKUDYDWLF-UHFFFAOYSA-N 50128285 3-(1-Methyl-1H-indol-3-yl)-4-[1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indol-3-yl]-pyrrole-2,5-dione::CHEMBL300138 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128285&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 176167 104020050 CHEMBL300138 5693 ZINC01494900 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50691114 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50675353 CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc12 InChI=1S/C16H16N6O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12/h3-8,20,23H,1-2H3,(H2,17,18,19) MFAQYJIYDMLAIM-UHFFFAOYSA-N 36409 2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol, PP242::CID24905147::US10172858, Table 2.1::US9828378, # 1 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=36409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=36409&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search P2X 4JT5 24905147 117643995 ZINC36056301 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50678217 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1 InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) WJEOLQLKVOPQFV-UHFFFAOYSA-N 50355495 CHEMBL1908391 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355495&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search G65 7TVX,5MQL,7JU7 10074640 136959519 63450 CHEMBL1908391 ZINC34177219 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50681073 CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 KGPGFQWBCSZGEL-ZDUSSCGKSA-N 25013 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25013&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search G93 3D0E,5U94 16725726 56374157 5196 ZINC34285211 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50686627 N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12 InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1 HFNKQEVNSGCOJV-OAHLLOKOSA-N 50355501 INCB-018424::RUXOLITINIB::RUXOLITINIB PHOSPHATE::US10112907, Example 00016::US10766894, Compound TABLE 1.1::US10875847, Compound JAKAFI::US11203595, TABLE 1.1::US11279703, TABLE 6.147 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355501&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search RXT 6VNK,6WTN,6VGL,4U5J,7F3G 25126798 136959525 66919 DB08877 ZINC43207851 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50672572 Fc1ccc(C(=O)NOCC2CC2)c(Nc2ccc(I)cc2Cl)c1F InChI=1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24) GFMMXOIFOQCCGU-UHFFFAOYSA-N 50132260 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide::2-(2-chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide::CHEMBL105442::CI-1040::PD-18435::PD-184352::US8575391, 341 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50132260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50132260&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 6918454 104023279 CHEMBL105442 5676 ZINC01489691 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50682619 Clc1cccc(Cl)c1C(=O)Nc1cn[nH]c1C(=O)NC1CCNCC1 InChI=1S/C16H17Cl2N5O2/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24) OVPNQJVDAFNBDN-UHFFFAOYSA-N 24654 4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-pyrazole-3,4-diamido::AT7519::JMC514986 Compound 33::pyrazole diamide, 33 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24654&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search LZE 7AGA,2VU3 11338033 56269605 5662 ZINC16052857 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50671052 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50671083 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50688475 COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)NC4=CCC(F)C=C4)cc3F)ccnc2cc1OCCCN1CCOCC1 InChI=1S/C34H36F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3,5-9,12,19-22H,2,4,10-11,13-18H2,1H3,(H,38,41)(H,39,42) SEJGTFPOEJWEGG-UHFFFAOYSA-N 50355504 CHEMBL1908393 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355504&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 57399640 136959528 CHEMBL1908393 ZINC73140828 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50689895 C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C InChI=1S/C19H19FN4O3/c1-10-6-13-14(23-10)4-5-15(17(13)20)27-19-18-12(3)16(26-8-11(2)25)7-24(18)22-9-21-19/h4-7,9,11,23,25H,8H2,1-3H3/t11-/m1/s1 WCWUXEGQKLTGDX-LLVKDONJSA-N 50184807 (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-yloxy)propan-2-ol::(R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol::BMS-540215::CHEMBL377300 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184807&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 11234052 104069124 CHEMBL377300 5671 ZINC13684256 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50679954 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50672929 O=C(N1CCNCC1)c1ccc(\C=C\c2n[nH]c3ccccc23)cc1 InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)/b10-7+ YYLKKYCXAOBSRM-JXMROGBWSA-N 50355496 CHEMBL1908397 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 94 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355496&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 11427553 136959520 CHEMBL1908397 ZINC43201999 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50685585 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50685597 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50674364 CS(=O)(=O)N1CCN(Cc2cc3nc(nc(N4CCOCC4)c3s2)-c2cccc3[nH]ncc23)CC1 InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) LHNIIDJUOCFXAP-UHFFFAOYSA-N 25028 4-[2-(1H-indazol-4-yl)-6-[(4-methanesulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine::GDC-0941::GDC0941::US10112932, pictilisib::US10851091, Compound pictilisib Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25028&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search GD9 3DBS,2Y3A,2WXP 17755052 56374172 65326 ZINC16052714 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50678673 C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 KTEIFNKAUNYNJU-GFCCVEGCSA-N 50306682 (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine::3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine::CHEMBL601719::CRIZOTINIB::PF-2341066::US10370379, Crizotinib::US10543199, Compound Crizotinib::US10780082, Compound Crizotinib::US11059827, Compound Crizotinib::US11517561, Compound Crizotinib::US9126941, PF-2341066::US9199944, Crizotinib::US9226923, Crizotinib Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50306682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50306682&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search VGH 2YFX,5AAA,5AAC,5AAB,4ANS,4ANQ,2XP2,2WGJ,3ZBF,4C9W,6IMZ 11626560 104161043 64310 CHEMBL601719 DB08700 4903 ZINC35902489 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50681491 CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) YZDJQTHVDDOVHR-UHFFFAOYSA-N 25617 N-[3-({5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl}carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide::PLX4720 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25617&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 324 3C4C,4WO5 24180719 56412907 DB06999 5703 ZINC39059267 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50683001 CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+ JWNPDZNEKVCWMY-VQHVLOKHSA-N 50161957 4-Dimethylamino-but-2-enoic acid {4-[3-chloro-4-(pyridin-2-ylmethoxy)-phenylamino]-3-cyano-7-ethoxy-quinolin-6-yl}-amide::CHEMBL180022::HKI-272::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide::N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide::NERATINIB::US10822334, Compound Neratinib Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161957&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 9915743 104048227 CHEMBL180022 5686 ZINC03916214 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50688702 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 260 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50690260 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50674425 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50677408 Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(cc12)C(=O)NOCCO InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) CYOHGALHFOKKQC-UHFFFAOYSA-N 50355497 AZD-6244::CHEMBL1614701 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355497&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 3EW 4U7Z,7JUZ,7JUT,7M0T 10127622 136959521 CHEMBL1614701 ZINC31773258 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50670155 COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35) QQWUGDVOUVUTOY-UHFFFAOYSA-N 482158 BDBM50242742::TAE684 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=482158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=482158&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 16038120 443551321 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50674548 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 OYONTEXKYJZFHA-SSHUPFPWSA-N 50242737 (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 1600 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242737&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 10461815 104099202 CHEMBL450786 5700 ZINC03938668 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50676013 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50677491 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50684491 Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1 InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24) UJIAQDJKSXQLIT-UHFFFAOYSA-N 25084 3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol::JMC504279 Compound 6::TG100-115 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 7800 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25084&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search B6J 5WNK 10427712 56374226 5715 ZINC06718666 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50671661 Cc1cnc2c(NCCN)nc3ccc(C)cc3n12 InChI=1S/C14H17N5/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18) PSPFQEBFYXJZEV-UHFFFAOYSA-N 25919 BMS-345541::BMS345541::CHEMBL471496::N-(2-aminoethyl)-3,12-dimethyl-2,5,8-triazatricyclo[7.4.0.0^{2,6}]trideca-1(13),3,5,7,9,11-hexaen-7-amine Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25919&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 9813758 56413207 CHEMBL471496 5669 ZINC13285379 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50673163 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50685927 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50674804 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 260 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50680503 CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 50322823 (S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide::AFATINIB::CHEMBL1173655::US10085983, Compound BIBW2992::US10196365, Afatinib::US10435400, Compound BIBW2992::US9388170, Afatinib::US9890168, Compound BIBW2992::WO2022090481, Example afatinib Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50322823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50322823&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 0WM 4G5J 10184653 104144352 61390 CHEMBL1173655 DB08916 5667 ZINC03976838 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50684769 OCCn1cc(c(n1)-c1ccncc1)-c1ccc2C(CCc2c1)N=O InChI=1S/C19H18N4O2/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25/h1,3,5-8,11-12,18,24H,2,4,9-10H2 RIGIGAFKKVBACY-UHFFFAOYSA-N 25628 2-{4-[(1Z)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethan-1-ol::AR00341677::CHEMBL525191::GDC-0879 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25628&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 91448975 56412918 CHEMBL525191 ZINC34640412 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50687665 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50689170 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50691984 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 39 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50683586 COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)Nc4n3)n2)cc(OC)c1OC InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30) NHHQJBCNYHBUSI-UHFFFAOYSA-N 60665 BDBM50249542::US9145414, R406::US9212178, R406 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 1200 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60665&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 585 3PIY,3FQS 11213558 316921779 DB07159 ZINC13555629 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50683684 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50673695 Cn1cc(cn1)-c1ccc2nnc(Sc3ccc4ncccc4c3)n2n1 InChI=1S/C18H13N7S/c1-24-11-13(10-20-24)16-6-7-17-21-22-18(25(17)23-16)26-14-4-5-15-12(9-14)3-2-8-19-15/h2-11H,1H3 BCZUAADEACICHN-UHFFFAOYSA-N 60589 6-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline (4)::BDBM50355498 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=60589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=60589&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search SX8 3DKF,3DKG 16187854 24782328 DB08584 ZINC15962404 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50675212 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50679460 COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(CC2)S(C)(=O)=O)nc1N InChI=1S/C18H21F2N5O4S/c1-29-13-4-3-12(19)15(20)14(13)16(26)11-9-22-18(24-17(11)21)23-10-5-7-25(8-6-10)30(2,27)28/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24) JRNJNYBQQYBCLE-UHFFFAOYSA-N 12621 2,4-Diamino-5-ketopyrimidine 39::5-[(2,3-difluoro-6-methoxyphenyl)carbonyl]-2-N-(1-methanesulfonylpiperidin-4-yl)pyrimidine-2,4-diamine::R547::[4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12621&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search LIA 2FVD 6918852 46513075 DB08094 5707 ZINC13983251 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50688149 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 140 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50678137 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50692545 Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31) JOOXLOJCABQBSG-UHFFFAOYSA-N 50332294 CHEMBL1287853::N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide::US10112907, Example 00018::US10730860, TABLE 1.3::US10766894, Compound TABLE 1.3::US11203595, TABLE 1.3::US11384069, Example T-5 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 160 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50332294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50332294&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 2TA 4OGJ,4PS5,6VNE 16722836 123111409 CHEMBL1287853 5716 ZINC19862646 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50696726 COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1 InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 XXJWYDDUDKYVKI-UHFFFAOYSA-N 50331096 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline::CHEMBL491473::Cediranib::US10464902, Cediranib::ZD-2171 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331096&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 9933475 123110211 CHEMBL491473 DB04849 5664 ZINC03948085 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50692617 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50694239 COc1c(Cl)cc2c3ccncc3[nH]c2c1NC(=O)c1cccnc1C InChI=1S/C19H15ClN4O2/c1-10-11(4-3-6-22-10)19(25)24-17-16-13(8-14(20)18(17)26-2)12-5-7-21-9-15(12)23-16/h3-9,23H,1-2H3,(H,24,25) ZNOLRTPMNMPLHY-UHFFFAOYSA-N 50309910 CHEMBL608154::ML-120B::N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methylnicotinamide Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50309910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50309910&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 9929127 104164271 CHEMBL608154 5694 ZINC06717113 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50692926 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50697197 CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1 InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34) GUBJNPWVIUFSTR-UHFFFAOYSA-N 50355499 CHEMBL1908395::CHEMBL1908842 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 3700 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355499&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 11676971 136959523 CHEMBL1908842CHEMBL1908395 ZINC38226716 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50697223 C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(CN3CCN(C)CC3)cc12)c1ccccc1C(F)(F)F InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 ZHJGWYRLJUCMRT-QGZVFWFLSA-N 50355500 CHEMBL1908394::US9695172, GSK461364 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 4500 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50355500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50355500&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 15983966 136959524 CHEMBL1908394 ZINC43154472 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50694495 CC[C@H]1N(C2CCCC2)c2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2N(C)C1=O InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1 XQVVPGYIWAGRNI-JOCHJYFZSA-N 25121 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide::BI 2536::CHEMBL513909::US10450297, Example 300::US8598172, 5 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25121&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search R78 4OGI,6MF9,6BQQ,7K0U,2RKU,6CW0,7LAI,4O74,4PY6,4I5M,5TCM,5C8G,5VBQ,7L9G,7L9L,7N7M 11364421 56374263 CHEMBL513909 5666 ZINC13986815 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50695833 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50694617 CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3N(CCc3cc2OC)C(=O)CN(C)C)nc2[nH]ccc12 InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) HZTYDQRUAWIZRE-UHFFFAOYSA-N 27817 2-{[2-({1-[2-(dimethylamino)acetyl]-5-methoxy-2,3-dihydro-1H-indol-6-yl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-6-fluoro-N-methylbenzamide::pyrrolo[2,3-d]pyrimidine deriv., 40 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27817&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 25182616 57560329 5683 ZINC43202844 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50697441 Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) HHZIURLSWUIHRB-UHFFFAOYSA-N 50237710 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide::AMN 107::AMN107::CHEMBL255863::NILOTINIB::US11649218, Example Nilotinib Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50237710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50237710&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search NIL 5MO4,3CS9,3GP0 644241 104056419 52172 CHEMBL255863 DB04868 5697 ZINC06716957 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50697626 CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1 InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26) VAARYSWULJUGST-UHFFFAOYSA-N 6568 6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfanyl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL386051::PD-173955::PD173955::US11136333, Compound PD173955 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6568&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search P17 1M52,5IA3 447077 8036145 49791 CHEMBL386051 DB02567 5699 ZINC02047743 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50695162 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt.1990 10.7270/Q25D8S70 22037378 Davis, MI; Hunt, JP; Herrgard, S; Ciceri, P; Wodicka, LM; Pallares, G; Hocker, M; Treiber, DK; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898937 COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) AAKJLRGGTJKAMG-UHFFFAOYSA-N 5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5446&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search AQ4 4HJO,6DWN,1M17 176870 8035065 114785 CHEMBL553 DB00530 4920 ZINC01546066 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898938 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898939 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) XGALLCVXEZPNRQ-UHFFFAOYSA-N 5447 CHEMBL939::GEFITINIB::Iressa::N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine::N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine::US10106508, Gefitinib::US10507209, Compound Gefitinib::US9416123, Gefitinib::US9730934, Gefitinib::US9783524, Gefitinib::WO2022090481, Example gefitinib::ZD1839::cid_123631 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5447&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 2ITO,2ITY,2ITZ 123631 8035066 49668 CHEMBL939 DB00317 4941 ZINC19632614 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898940 COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1 InChI=1S/C20H22N4O3/c1-25-16-6-3-13(4-7-16)12-27-17-8-5-14(10-18(17)26-2)9-15-11-23-20(22)24-19(15)21/h3-8,10-11H,9,12H2,1-2H3,(H4,21,22,23,24) MYQAUKPBNJWPIE-UHFFFAOYSA-N 32362 5-[[3-methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]pyrimidine-2,4-diamine::GW-2580::[2-amino-5-(3-methoxy-4-p-anisyloxy-benzyl)pyrimidin-4-yl]amine::cid_11617559 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=32362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=32362&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search MUJ 4AT5 11617559 252615797 5685 ZINC13985942 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898941 CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) CUIHSIWYWATEQL-UHFFFAOYSA-N 26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26474&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 10113978 56464911 71219 DB06589 5698 ZINC11617039 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898942 CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34) KTUFNOKKBVMGRW-UHFFFAOYSA-N 13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13530&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search STI 6HD6,6HD4,2HYY,4BKJ,2PL0,3GVU,6NPU,6NPV,6NPE,4CSV,3MS9,3MSS,4R7I,7N9G,2OIQ,1IEP,1XBB,3HEC,1T46,3FW1,3PYY,6VXH,6JOL,3K5V,5MQT,3OEZ,6KTN,1OPJ 5291 46513933 45783 CHEMBL941 DB00619 5687 ZINC19632618 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898943 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22) KDKUVYLMPJIGKA-UHFFFAOYSA-N 6866 1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b::4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzene-1-sulfonamide::4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]-benzenesulfonamide::CHEMBL191003::JNJ-7706621::cid_5330790 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 1300 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6866&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search SKE 5WIN,5USZ,5USY,5DR9,8B99,5OBR,6DRW,5DPV,5DR6,6P11,6P10,3AMA,4QMU,5DT0 5330790 8036422 CHEMBL191003 ZINC03938688 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898944 CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1 InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) BCFGMOOMADDAQU-UHFFFAOYSA-N 5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5445&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search FMM 1XKK,3BBT 208908 8035064 49603 CHEMBL554 DB01259 5692 ZINC01550477 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898945 CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21 InChI=1S/C28H28N4O3/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24/h3-10,16-18H,11-15H2,1-2H3,(H,29,33,34)/t18-/m0/s1 ZCBUQCWBWNUWSU-SFHVURJKSA-N 17055 (18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-triazahexacyclo[19.6.1.1^{7,14}.0^{2,6}.0^{8,13}.0^{22,27}]nonacosa-1(28),2(6),7(29),8(13),9,11,22(27),23,25-nonaene-3,5-dione::(9S)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-di(metheno)dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione::K00587a::LY 333531::LY-333531::LY333531::Ruboxistaurin::cid_153999 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 830 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=17055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=17055&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search LY4 2J2I,1UU3 153999 46517285 5263 ZINC03812168 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898946 COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1 InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36(16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4-6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38) UXXQOJXBIDBUAC-UHFFFAOYSA-N 13535 4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide::4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-[4-(1-methylethoxy)phenyl]piperazine-1-carboxamide::4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-(4-propan-2-yloxyphenyl)-1-piperazinecarboxamide::4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide::CHEMBL124660::MLN-518::MLN518::N-(4-isopropoxyphenyl)-4-[6-methoxy-7-(3-piperidinopropoxy)quinazolin-4-yl]piperazine-1-carboxamide::cid_3038522 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13535&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 3038522 46513936 CHEMBL124660 DB05465 ZINC03966243 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898947 OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1 InChI=1S/C25H15ClF2N4O2/c26-15-6-9-17-18(10-15)23(21-19(27)2-1-3-20(21)28)29-11-14-12-30-25(32-22(14)17)31-16-7-4-13(5-8-16)24(33)34/h1-10,12H,11H2,(H,33,34)(H,30,31,32) HHFBDROWDBDFBR-UHFFFAOYSA-N 31093 4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::4-[[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]benzoic acid::BDBM31832::CHEMBL259084::MLN-8054::cid_11712649 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31093&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search ZZL 2X81,5IA1,2WTW,2WTV 11712649 252615338 CHEMBL259084 5696 ZINC18825334 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898948 Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 TUVCWJQQGGETHL-UHFFFAOYSA-N 25045 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol::3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol::3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol::3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol::CHEMBL538346::PI-103::US9637488, PI-103::cid_9884685::mTOR Inhibitor, PI103::pyridofuropyrimidine derivative, 2 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25045&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search X6K 2X6K,4L23,4JT6 9884685 56374189 CHEMBL538346 5701 ZINC03963016 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898950 Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1 InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25) YCOYDOIWSSHVCK-UHFFFAOYSA-N 4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4851&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 151194 8034494 CHEMBL75232CHEMBL101253 DB04879 6052 ZINC00007460 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898951 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898952 Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) QHKYPYXTTXKZST-UHFFFAOYSA-N 13531 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole::4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol::4-[4-(4-fluorophenyl)-5-(4-pyridyl)-4-imidazolin-2-ylidene]cyclohexa-2,5-dien-1-one::4-[5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-imidazol-2-yl]phenol::SB-202190::SB202190::biotinylated SB202190 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13531&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 5353940 172097219 ZINC14951176 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898953 CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) CDMGBJANTYXAIV-UHFFFAOYSA-N 13336 4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine::4-{4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl}pyridine::CHEMBL10::SB-203580::SB203580::cid_176155 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13336&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 1A9U,1PME,2EWA 176155 46513744 CHEMBL10 5269 ZINC96006137 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898954 NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCOc2c1)-c1ccccn1 InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) FHYUGAJXYORMHI-UHFFFAOYSA-N 50110208 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::4-(5-(benzo[d][1,3]dioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide::4-(5-benzo[1,3]dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)-benzamide::CHEMBL440084::SB-431542::cid_4521392 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110208&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 085 3TZM 4521392 104005054 CHEMBL440084 ZINC00603769 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898955 CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1 InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) MLDQJTXFUGDVEO-UHFFFAOYSA-N 16673 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide::4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-picolinamide;tosylic acid::BAY 43-9006::BAY 439006::BAY439006::CHEMBL1336::Hit compound, 8::Nexavar::Sorafenib::Sorafenib, 4::US10183928, Sorafenib::US10202365, Compound Sorafenib::US10227329, Compound Sorafenib::US10584114, Compound Sorafenib::US10774070, Compound Sorafenib::US10980809, Example Sorafenib::US11279688, Compound Sorafenib::US11505527, Compound Sorafenib::US9029401, Sorafenib::US9469639, Sorafenib::US9902709, Comparative example 1::Xarelto::cid_216239 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16673&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search BAX 3GCS,4ASD,3WZE,5HI2,3HEG,1UWH,1UWJ,3RGF 216239 46516901 50924 CHEMBL1336 DB00398 5711 ZINC01493878 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898957 Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1 InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1 CTNPALGJUAXMMC-PMFHANACSA-N 31095 5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[(2S)-3-morpholin-4-yl-2-oxidanyl-propyl]-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-keto-indolin-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholino-propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-(4-morpholinyl)propyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU-14813::cid_10138259 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 260 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31095&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 10138259 252615339 ZINC18825344 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898958 CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- WINHZLLDWRZWRT-ATVHPVEESA-N 4814 CHEMBL535::N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide::N-[2-(diethylamino)ethyl]-5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-1H-pyrrole-3-carboxamide::SU11248::SUNITINIB::SUNITINIB MALATE::US10464902, Sunitinib::US9163010, Sunitinib::US9914707, SU11248 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 39 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4814&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search B49 6NG0,4KS8,3G0F,3G0E,2Y7J,6JOK,6M11,3MIY,3TI1,4QMZ,6V0X,6NFZ,6NFY,4AGD 5329102 8034462 38940 CHEMBL535 DB01268 5713 ZINC03964325 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50898959 CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) GCIKSSRWRFVXBI-UHFFFAOYSA-N 13534 CHEMBL572878::N-[4-({4-[(3-methyl-1H-pyrazol-5-yl)amino]-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl}sulfanyl)phenyl]cyclopropanecarboxamide::N-[4-[[4-(4-methylpiperazino)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thio]phenyl]cyclopropanecarboxamide::VX-680::VX680::cyclopropane carboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2ylsulphanyl]-phenyl}-amide Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 140 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13534&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search VX6 2F4J,6GR9,6BRJ,3E5A,4ZOG,4B8M,5WNM,3AMB,4JBQ,4AF3,2XYN 5494449 46513935 CHEMBL572878 5718 ZINC03820040 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894023 Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1 InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28) MPVGZUGXCQEXTM-UHFFFAOYSA-N 21079 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methyl-phenyl)urea::1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea::1-[4-(3-azanyl-1H-indazol-4-yl)phenyl]-3-(2-fluoranyl-5-methyl-phenyl)urea::3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-5-methylphenyl)urea::ABT-869::Aminoindazole, 3::CHEMBL223360::cid_11485656 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21079&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 11485656 49689152 CHEMBL223360 5657 ZINC06718813 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894024 CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12 InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) RAHBGWKEPAQNFF-UHFFFAOYSA-N 24773 AMG 706::AMG-706::Motesanib::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)-3-pyridinecarboxamide::N-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide::N-(3,3-dimethyl-2,3-dihydro-1H-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide::N-(3,3-dimethylindolin-6-yl)-2-(4-pyridylmethylamino)nicotinamide::US10464902, Motesanib::cid_11667893 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24773&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 706 3EFL 11667893 56269724 51098 5660 ZINC18710082 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894025 CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1 InChI=1S/C26H30F3N7O2/c1-3-35-10-12-36(13-11-35)16-18-4-5-20(14-22(18)26(27,28)29)34-25(37)33-19-6-8-21(9-7-19)38-24-15-23(30-2)31-17-32-24/h4-9,14-15,17H,3,10-13,16H2,1-2H3,(H,30,31,32)(H2,33,34,37) ODPGGGTTYSGTGO-UHFFFAOYSA-N 31085 1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea::1-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::1-[4-[(4-ethylpiperazino)methyl]-3-(trifluoromethyl)phenyl]-3-[4-[6-(methylamino)pyrimidin-4-yl]oxyphenyl]urea::AST-487::cid_11409972 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31085&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 11409972 252615335 5661 ZINC23247639 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894026 CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)n[nH]3)ncnc2c1 InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) QYZOGCMHVIGURT-UHFFFAOYSA-N 26300 2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}quinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide::CHEMBL215152::cid_16007391::pyrazoloquinazoline deriv., 34 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26300&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search YJA 4C2V 16007391 56464737 CHEMBL215152 5663 ZINC16697102 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894027 Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37) MVCOAUNKQVWQHZ-UHFFFAOYSA-N 13533 1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(4-methylphenyl)-3-pyrazolyl]-3-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea::1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::1-[5-tert-butyl-2-(p-tolyl)pyrazol-3-yl]-3-[4-(2-morpholinoethoxy)-1-naphthyl]urea::3-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-1-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea::3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-1-{4-[2-(morpholin-4-yl)ethoxy]naphthalen-1-yl}urea::BIRB 796::BIRB-796::BIRB-796, 3::CHEMBL103667::D3RKN_73::Doramapimod::US11407771, Compound 43::US8933228, BIRB 796::US9187470, 43 (BIRB-796)::US9242960, BIRB 796::US9260410, BIRB796::cid_156422::diaryl urea compound 10 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13533&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search B96 4JVG,1KV2,6GTT,5N66,4TWN,3NPC,3FZS 156422 46513934 CHEMBL103667 DB03044 5668 ZINC24044436 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894028 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894029 CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) PIQCTGMSNWUMAF-UHFFFAOYSA-N 25118 (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,3-dihydrobenzimidazol-2-ylidene]carbostyril::4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl]-1,2-dihydroquinolin-2-one::CHEMBL522892::CHIR-258 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 260 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25118&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 9886808 56374260 CHEMBL522892 5962 ZINC03816310 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894030 Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12 InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34) YABJJWZLRMPFSI-UHFFFAOYSA-N 31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31088&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 55J 5CT7 11656518 252615336 5674 ZINC18710085 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894031 Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) OMZCMEYTWSXEPZ-UHFFFAOYSA-N 4779 CHEMBL31965::CHEMBL545315::CI-1033::Canertinib::N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide::PD0183805::US10507209, Compound CI-1033::US9730934, CI-1033::cid_156414 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4779&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 156414 8034429 61399 CHEMBL31965CHEMBL545315 DB05424 5675 ZINC27439698 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894032 C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N 50193995 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-(4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile::3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile::CHEMBL221959::CP-690550::TOFACITINIB CITRATE::Tofacitinib::Tofacitinib citrate (1)::US10112907, Example 00035::US10399979, Compound Tofacitinib::US10766894, Compound TABLE 1.20::US10875847, Compound Tofacitinib::US11078206, Example Tofacitinib::US11203595, TABLE 1.20::US11339167, Example Tofacitinib Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193995&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search MI1 3LXK,3LXN,4OTI,3EYG,3FUP 9926791 104076339 71200 CHEMBL221959 DB08183 5677 ZINC03818808 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894033 COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1 InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+ LLVZBTWPGQVVLW-SNAWJCMRSA-N 31340 2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide::2-methoxy-N-[(E)-3-[4-[3-methyl-4-[(6-methyl-3-pyridyl)oxy]anilino]quinazolin-6-yl]allyl]acetamide::2-methoxy-N-[(E)-3-[4-[[3-methyl-4-(6-methylpyridin-3-yl)oxy-phenyl]amino]quinazolin-6-yl]prop-2-enyl]ethanamide::CHEMBL483321::CP-724714::cid_9874913 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31340&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 9874913 252615341 CHEMBL483321 ZINC03817105 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894034 Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1 InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27) ZBNZXTGUTAYRHI-UHFFFAOYSA-N 13216 BMS-354825::CHEMBL1421::DASATINIB::N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide::N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide::US10294227, Code Dasatinib::cid_3062316::med.21724, Compound Dasatinib Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13216&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 1N1 5BVW,5OWR,6FNM,6BSD,5I9Y,2ZVA,3OCT,7ERK,3QLG,3SXR,7N9G,4XLI,3OHT,2Y6O,3LFA,4XEY,2GQG,3K54,3G5D,4QMS,5VCV,5H2U 3062316 46513626 49375 CHEMBL1421 DB01254 5678 ZINC21982951 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50894035 CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ WVUNYSQLFKLYNI-AATRIKPKSA-N 31090 (E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-ethoxy-6-quinolyl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide::(E)-N-[4-(3-chloro-4-fluoroanilino)-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide::(E)-N-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-3-cyano-7-ethoxy-quinolin-6-yl]-4-(dimethylamino)but-2-enamide::EKB-569::Pelitinib::cid_6445562 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 2600 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31090&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 93J 7AXM,5VCW 6445562 252615337 38927 ZINC00602803 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50902134 Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1 InChI=1S/C19H9Cl2F2N3OS/c20-11-2-1-3-12(21)17(11)18-14-5-7-16(25-26(14)9-24-19(18)27)28-15-6-4-10(22)8-13(15)23/h1-9H VEPKQEUBKLEPRA-UHFFFAOYSA-N 15244 5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfanylpyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-a]pyridazin-6-one::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6-pyrimido[1,6-b]pyridazinone::5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]pyrimido[1,6-b]pyridazin-6-one::5-(2,6-dichlorophenyl)-9-(2,4-difluorophenyl)sulfanyl-1,3,10-triazabicyclo[4.4.0]deca-2,5,7,9-tetraen-4-one::5-[2,6-bis(chloranyl)phenyl]-2-[2,4-bis(fluoranyl)phenyl]sulfanyl-pyrimido[1,6-b]pyridazin-6-one::VX-745::VX745::cid_3038525 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=15244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=15244&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 52P 3ZSI,3HP5,3FC1 3038525 46515551 DB07138 ZINC13493055 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 50902135 COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) UHTHHESEBZOYNR-UHFFFAOYSA-N 21 CHEMBL24828::N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine::VANDETANIB::ZD-6474::ZD6474::cid_3081361 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1038/nbt1358 10.7270/Q2TT4RX2 18183025 Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP Ambit Biosciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search ZD6 2IVU 3081361 8030012 49960 CHEMBL24828 DB08764 ZINC03834198 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250414 CC1(C)CN(C(=O)N1)c1ncc(C(=O)Nc2cccc(c2)C(F)(F)F)c(N)n1 InChI=1S/C17H17F3N6O2/c1-16(2)8-26(15(28)25-16)14-22-7-11(12(21)24-14)13(27)23-10-5-3-4-9(6-10)17(18,19)20/h3-7H,8H2,1-2H3,(H,23,27)(H,25,28)(H2,21,22,24) FUSNOPLQVRUIIM-UHFFFAOYSA-N 50511409 Imanixil Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 3800 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511409&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 216289 440719991 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250416 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2cccc(c2)-c2ccccc2)c1 InChI=1S/C35H32N6O2/c1-41(2)20-8-15-34(42)39-29-18-16-26(17-19-29)35(43)40-31-14-7-13-30(22-31)38-33-23-32(36-24-37-33)28-12-6-11-27(21-28)25-9-4-3-5-10-25/h3-19,21-24H,20H2,1-2H3,(H,39,42)(H,40,43)(H,36,37,38)/b15-8+ NDCIHUPRPPFTMY-OVCLIPMQSA-N 50511411 CHEMBL4563077 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 30400 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511411&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155559558 440719993 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250428 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 InChI=1S/C30H28N8O2/c1-38(2)14-4-7-28(39)36-23-10-8-20(9-11-23)30(40)37-25-6-3-5-24(16-25)35-27-17-26(33-19-34-27)22-15-21-12-13-31-29(21)32-18-22/h3-13,15-19H,14H2,1-2H3,(H,31,32)(H,36,39)(H,37,40)(H,33,34,35)/b7-4+ BVRLDWAVDIENKW-QPJJXVBHSA-N 50511413 CHEMBL4571099 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 10900 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511413&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 134451943 440719995 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250429 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2ccc3nn(C)cc3c2)c1 InChI=1S/C31H30N8O2/c1-38(2)15-5-8-30(40)35-24-12-9-21(10-13-24)31(41)36-26-7-4-6-25(17-26)34-29-18-28(32-20-33-29)22-11-14-27-23(16-22)19-39(3)37-27/h4-14,16-20H,15H2,1-3H3,(H,35,40)(H,36,41)(H,32,33,34)/b8-5+ PZCJVFWKOFSFBK-VMPITWQZSA-N 50511423 CHEMBL4454740 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 15800 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511423&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 134451949 440720005 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250430 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)NCc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1 InChI=1S/C32H31N7O2/c1-39(2)16-6-11-31(40)38-24-14-12-23(13-15-24)32(41)34-19-22-7-5-8-25(17-22)37-30-18-29(35-21-36-30)27-20-33-28-10-4-3-9-26(27)28/h3-15,17-18,20-21,33H,16,19H2,1-2H3,(H,34,41)(H,38,40)(H,35,36,37)/b11-6+ BTXPFUHSBHVJEP-IZZDOVSWSA-N 50511412 CHEMBL4550598 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 29800 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511412&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155555293 440719994 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250431 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 InChI=1S/C31H30N8O2/c1-20-6-9-25(37-31(41)21-7-10-24(11-8-21)36-29(40)5-4-14-39(2)3)16-26(20)38-28-17-27(34-19-35-28)23-15-22-12-13-32-30(22)33-18-23/h4-13,15-19H,14H2,1-3H3,(H,32,33)(H,36,40)(H,37,41)(H,34,35,38)/b5-4+ KBKWTUJGGGAQEV-SNAWJCMRSA-N 50511424 CHEMBL4518868 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 20500 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511424&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 134451945 440720006 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250432 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 InChI=1S/C30H28N8O2/c1-38(2)13-5-10-28(39)36-23-7-3-6-21(15-23)30(40)37-25-9-4-8-24(16-25)35-27-17-26(33-19-34-27)22-14-20-11-12-31-29(20)32-18-22/h3-12,14-19H,13H2,1-2H3,(H,31,32)(H,36,39)(H,37,40)(H,33,34,35)/b10-5+ WMNZWNFVXMVDBY-BJMVGYQFSA-N 50511418 CHEMBL4533123 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 8900 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511418&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 134456954 440720000 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250433 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)cc1 InChI=1S/C30H28N8O2/c1-38(2)15-3-4-28(39)36-24-7-5-20(6-8-24)30(40)37-25-11-9-23(10-12-25)35-27-17-26(33-19-34-27)22-16-21-13-14-31-29(21)32-18-22/h3-14,16-19H,15H2,1-2H3,(H,31,32)(H,36,39)(H,37,40)(H,33,34,35)/b4-3+ ZXIMCTYIDWUSCI-ONEGZZNKSA-N 50511425 CHEMBL4572941 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 35600 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511425 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511425&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 134456941 440720007 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250434 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncnc3n(ccc23)-c2ccc(C)cc2)c1 InChI=1S/C32H31N7O2/c1-22-9-15-27(16-10-22)39-19-17-28-30(33-21-34-31(28)39)36-25-6-4-7-26(20-25)37-32(41)23-11-13-24(14-12-23)35-29(40)8-5-18-38(2)3/h4-17,19-21H,18H2,1-3H3,(H,35,40)(H,37,41)(H,33,34,36)/b8-5+ QSHQSGKUSRNJPU-VMPITWQZSA-N 50511421 CHEMBL4439287 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 9900 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511421&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155513915 440720003 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250435 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H29N7O2/c1-38(2)16-6-11-30(39)36-22-14-12-21(13-15-22)31(40)37-24-8-5-7-23(17-24)35-29-18-28(33-20-34-29)26-19-32-27-10-4-3-9-25(26)27/h3-15,17-20,32H,16H2,1-2H3,(H,36,39)(H,37,40)(H,33,34,35)/b11-6+ MJJJRRMQCUUKEO-IZZDOVSWSA-N 50511422 CHEMBL4446338 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 5900 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511422&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search N51 6OSP 134451950 440720004 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250438 CN(C)C\C=C\C(=O)NC1CCN(CC1)C(=O)Cc1cccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 InChI=1S/C30H34N8O2/c1-37(2)12-4-7-28(39)36-24-9-13-38(14-10-24)29(40)16-21-5-3-6-25(15-21)35-27-18-26(33-20-34-27)23-17-22-8-11-31-30(22)32-19-23/h3-8,11,15,17-20,24H,9-10,12-14,16H2,1-2H3,(H,31,32)(H,36,39)(H,33,34,35)/b7-4+ XGNKCLMEMNKVHO-QPJJXVBHSA-N 50511420 CHEMBL4449493 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 10100 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511420&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 124157094 440720002 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250439 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(Nc3cccc(c3)-c3ccccc3)ncn2)c1 InChI=1S/C35H33N7O2/c1-42(2)20-8-15-34(43)40-28-18-16-26(17-19-28)35(44)41-31-14-7-13-30(22-31)39-33-23-32(36-24-37-33)38-29-12-6-11-27(21-29)25-9-4-3-5-10-25/h3-19,21-24H,20H2,1-2H3,(H,40,43)(H,41,44)(H2,36,37,38,39)/b15-8+ LNAREMFAESIWFA-OVCLIPMQSA-N 50511416 CHEMBL4537067 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 24500 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511416&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155548306 440719998 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250441 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(Nc3ccc(C)cc3)ncn2)c1 InChI=1S/C30H31N7O2/c1-21-9-13-23(14-10-21)33-27-19-28(32-20-31-27)34-25-6-4-7-26(18-25)36-30(39)22-11-15-24(16-12-22)35-29(38)8-5-17-37(2)3/h4-16,18-20H,17H2,1-3H3,(H,35,38)(H,36,39)(H2,31,32,33,34)/b8-5+ DKLNCUOAEWFPFL-VMPITWQZSA-N 50511415 CHEMBL4461694 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 6200 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511415&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155528635 440719997 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250446 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(Nc3ccc(cc3)-c3ccccc3)ncn2)c1 InChI=1S/C35H33N7O2/c1-42(2)21-7-12-34(43)40-29-19-15-27(16-20-29)35(44)41-31-11-6-10-30(22-31)39-33-23-32(36-24-37-33)38-28-17-13-26(14-18-28)25-8-4-3-5-9-25/h3-20,22-24H,21H2,1-2H3,(H,40,43)(H,41,44)(H2,36,37,38,39)/b12-7+ YYHURGHJHGISNF-KPKJPENVSA-N 50511414 CHEMBL4472811 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 6300 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511414&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155535959 440719996 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250447 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)ccc1C InChI=1S/C32H31N7O2/c1-21-10-13-24(36-30-18-29(34-20-35-30)26-19-33-27-8-5-4-7-25(26)27)17-28(21)38-32(41)22-11-14-23(15-12-22)37-31(40)9-6-16-39(2)3/h4-15,17-20,33H,16H2,1-3H3,(H,37,40)(H,38,41)(H,34,35,36)/b9-6+ QLSXOMXXGMCOEW-RMKNXTFCSA-N 50511417 CHEMBL4464636 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 33600 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511417&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155530669 440719999 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51250448 CN(C)C\C=C\C(=O)NC1CCC(CC1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2cnc3[nH]ccc3c2)c1 InChI=1S/C30H34N8O2/c1-38(2)14-4-7-28(39)36-23-10-8-20(9-11-23)30(40)37-25-6-3-5-24(16-25)35-27-17-26(33-19-34-27)22-15-21-12-13-31-29(21)32-18-22/h3-7,12-13,15-20,23H,8-11,14H2,1-2H3,(H,31,32)(H,36,39)(H,37,40)(H,33,34,35)/b7-4+ TWNLBUPLPGVPQC-QPJJXVBHSA-N 50511419 CHEMBL4517979 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 31800 ChEMBL 10.1021/acsmedchemlett.9b00402 10.7270/Q2TM7FDP 32184968 Manz, TD; Sivakumaren, SC; Yasgar, A; Hall, MD; Davis, MI; Seo, HS; Card, JD; Ficarro, SB; Shim, H; Marto, JA; Dhe-Paganon, S; Sasaki, AT; Boxer, MB; Simeonov, A; Cantley, LC; Shen, M; Zhang, T; Ferguson, FM; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511419 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511419&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 134451952 440720001 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295128 CN(C)c1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C17H16N4OS/c1-21(2)14-5-3-12(4-6-14)13-7-11(9-19-10-13)8-15-16(22)20-17(18)23-15/h3-10H,1-2H3,(H2,18,20,22)/b15-8- MFZLMACKJGFEJM-NVNXTCNLSA-N 50527928 CHEMBL4538609 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527928&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155549000 440736510 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295129 CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1cccc2[nH]ccc12 InChI=1S/C20H17N3O2S/c1-26(24,25)23-17-7-5-14(6-8-17)15-11-16(13-21-12-15)18-3-2-4-20-19(18)9-10-22-20/h2-13,22-23H,1H3 KKMZWHRTQLNOCF-UHFFFAOYSA-N 50527929 CHEMBL4455633 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 9400 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527929&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155524400 440736511 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295130 CS(=O)(=O)Nc1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C16H14N4O3S2/c1-25(22,23)20-13-4-2-11(3-5-13)12-6-10(8-18-9-12)7-14-15(21)19-16(17)24-14/h2-9,20H,1H3,(H2,17,19,21)/b14-7- AGHDPPGOJJYURV-AUWJEWJLSA-N 50527927 CHEMBL4436648 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 1700 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527927&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search UHJ 6UX9 155512072 440736509 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295131 CNC(=O)Nc1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C17H15N5O2S/c1-19-17(24)21-13-4-2-11(3-5-13)12-6-10(8-20-9-12)7-14-15(23)22-16(18)25-14/h2-9H,1H3,(H2,18,22,23)(H2,19,21,24)/b14-7- MFOMNRXSNXKNFH-AUWJEWJLSA-N 50527925 CHEMBL4577337 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 8600 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527925&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155564892 440736507 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295132 CS(=O)(=O)c1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C16H13N3O3S2/c1-24(21,22)13-4-2-11(3-5-13)12-6-10(8-18-9-12)7-14-15(20)19-16(17)23-14/h2-9H,1H3,(H2,17,19,20)/b14-7- JITAYSQVLSDQMN-AUWJEWJLSA-N 50527930 CHEMBL4436523 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527930&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155511880 440736512 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295133 CNS(=O)(=O)c1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C16H14N4O3S2/c1-18-25(22,23)13-4-2-11(3-5-13)12-6-10(8-19-9-12)7-14-15(21)20-16(17)24-14/h2-9,18H,1H3,(H2,17,20,21)/b14-7- WYQFLYFUQOJPHD-AUWJEWJLSA-N 50527931 CHEMBL4519752 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 4300 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527931&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155541687 440736513 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295134 CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1ccc2[nH]ccc2c1 InChI=1S/C20H17N3O2S/c1-26(24,25)23-19-5-2-14(3-6-19)17-11-18(13-21-12-17)15-4-7-20-16(10-15)8-9-22-20/h2-13,22-23H,1H3 LVEUYCROGSLRHA-UHFFFAOYSA-N 50527932 CHEMBL4456203 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 22000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527932&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155525131 440736514 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295135 CC(=O)Nc1cccc(Nc2cncc(c2)-c2ccc(NS(C)(=O)=O)cc2)c1 InChI=1S/C20H20N4O3S/c1-14(25)22-18-4-3-5-19(11-18)23-20-10-16(12-21-13-20)15-6-8-17(9-7-15)24-28(2,26)27/h3-13,23-24H,1-2H3,(H,22,25) FQEMDMVJLDHKBF-UHFFFAOYSA-N 50527933 CHEMBL4454398 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 45000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527933&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155523703 440736515 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295136 CC(=O)Nc1cccc(Oc2cncc(c2)-c2ccc(NS(C)(=O)=O)cc2)c1 InChI=1S/C20H19N3O4S/c1-14(24)22-18-4-3-5-19(11-18)27-20-10-16(12-21-13-20)15-6-8-17(9-7-15)23-28(2,25)26/h3-13,23H,1-2H3,(H,22,24) PUYRDZFEFLWIMV-UHFFFAOYSA-N 50527934 CHEMBL4573568 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 25000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527934&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155563510 440736516 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295137 CC(=O)Nc1cccc(c1)-c1cncc(c1)-c1ccc(NS(C)(=O)=O)cc1 InChI=1S/C20H19N3O3S/c1-14(24)22-20-5-3-4-16(11-20)18-10-17(12-21-13-18)15-6-8-19(9-7-15)23-27(2,25)26/h3-13,23H,1-2H3,(H,22,24) BEUIXJCNKIYAAU-UHFFFAOYSA-N 50527935 CHEMBL4567681 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 36000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527935&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155560591 440736517 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295138 CS(=O)(=O)Nc1ccc(cc1)-c1cncc(\C=C2/CC(=O)NC2=O)c1 InChI=1S/C17H15N3O4S/c1-25(23,24)20-15-4-2-12(3-5-15)14-7-11(9-18-10-14)6-13-8-16(21)19-17(13)22/h2-7,9-10,20H,8H2,1H3,(H,19,21,22)/b13-6+ PJUYTBPUBUDUFG-AWNIVKPZSA-N 50527936 CHEMBL4559878 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 27000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527936&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155557837 440736518 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295139 CS(=O)(=O)Nc1ccc(cc1)-c1cncc(\C=C2/OC(=O)NC2=O)c1 InChI=1S/C16H13N3O5S/c1-25(22,23)19-13-4-2-11(3-5-13)12-6-10(8-17-9-12)7-14-15(20)18-16(21)24-14/h2-9,19H,1H3,(H,18,20,21)/b14-7- WUVIMTDBONSKKB-AUWJEWJLSA-N 50527937 CHEMBL4540008 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527937&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155550112 440736519 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295152 FC(F)(F)c1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C16H10F3N3OS/c17-16(18,19)12-3-1-10(2-4-12)11-5-9(7-21-8-11)6-13-14(23)22-15(20)24-13/h1-8H,(H2,20,22,23)/b13-6- QMBBYLUZMCPMTA-MLPAPPSSSA-N 50527941 CHEMBL4475338 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 26000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527941&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155537597 440736523 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295153 Fc1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C15H10FN3OS/c16-12-3-1-10(2-4-12)11-5-9(7-18-8-11)6-13-14(20)19-15(17)21-13/h1-8H,(H2,17,19,20)/b13-6- KYVDESWKZLGEKQ-MLPAPPSSSA-N 50527940 CHEMBL4441998 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 28000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527940&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155515354 440736522 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295159 COc1ccc(-c2cncc(\C=C3/SC(=N)NC3=O)c2)c2ccccc12 InChI=1S/C20H15N3O2S/c1-25-17-7-6-14(15-4-2-3-5-16(15)17)13-8-12(10-22-11-13)9-18-19(24)23-20(21)26-18/h2-11H,1H3,(H2,21,23,24)/b18-9- BPUXFIWTVVLVDM-NVMNQCDNSA-N 50527944 CHEMBL4459957 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527944&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155527602 440736526 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295160 CC(=O)Nc1cccc(c1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C17H14N4O2S/c1-10(22)20-14-4-2-3-12(7-14)13-5-11(8-19-9-13)6-15-16(23)21-17(18)24-15/h2-9H,1H3,(H,20,22)(H2,18,21,23)/b15-6- IOVDIWPOZDYYSY-UUASQNMZSA-N 50527945 CHEMBL4527801 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527945&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155545333 440736527 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295161 CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1cccc2NC(=O)Cc12 InChI=1S/C20H17N3O3S/c1-27(25,26)23-16-7-5-13(6-8-16)14-9-15(12-21-11-14)17-3-2-4-19-18(17)10-20(24)22-19/h2-9,11-12,23H,10H2,1H3,(H,22,24) WUBJFKQHSLPIGO-UHFFFAOYSA-N 50527946 CHEMBL4467678 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 15000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527946&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155532457 440736528 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295163 CS(=O)(=O)Nc1ccc(cc1)-c1cc(\C=C2/SC(=N)NC2=O)cnc1N InChI=1S/C16H15N5O3S2/c1-26(23,24)21-11-4-2-10(3-5-11)12-6-9(8-19-14(12)17)7-13-15(22)20-16(18)25-13/h2-8,21H,1H3,(H2,17,19)(H2,18,20,22)/b13-7- CGMYGQBFJRPLIT-QPEQYQDCSA-N 50527938 CHEMBL4454033 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 2700 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527938&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155523946 440736520 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295165 CC(=O)Nc1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C17H14N4O2S/c1-10(22)20-14-4-2-12(3-5-14)13-6-11(8-19-9-13)7-15-16(23)21-17(18)24-15/h2-9H,1H3,(H,20,22)(H2,18,21,23)/b15-7- BLPOJDVRPDPMDP-CHHVJCJISA-N 50527942 CHEMBL4458985 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527942&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155527152 440736524 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295166 CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1ccc2cc[nH]c2c1 InChI=1S/C20H17N3O2S/c1-26(24,25)23-19-6-4-14(5-7-19)17-10-18(13-21-12-17)16-3-2-15-8-9-22-20(15)11-16/h2-13,22-23H,1H3 OCQOLFRRSJQDMD-UHFFFAOYSA-N 50527948 CHEMBL4440465 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 29000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527948&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155514328 440736530 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295167 CNC(=O)Nc1ccc(cc1)-c1cncc(c1)-c1ccc(NS(C)(=O)=O)cc1 InChI=1S/C20H20N4O3S/c1-21-20(25)23-18-7-3-14(4-8-18)16-11-17(13-22-12-16)15-5-9-19(10-6-15)24-28(2,26)27/h3-13,24H,1-2H3,(H2,21,23,25) IPBMKGBUWZJLJI-UHFFFAOYSA-N 50527926 CHEMBL4449110 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 43000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527926&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155520407 440736508 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295168 CS(=O)(=O)Nc1ccc(cc1)-c1cncc(\C=C2/SC(=O)NC2=O)c1 InChI=1S/C16H13N3O4S2/c1-25(22,23)19-13-4-2-11(3-5-13)12-6-10(8-17-9-12)7-14-15(20)18-16(21)24-14/h2-9,19H,1H3,(H,18,20,21)/b14-7- IMUDILUTOPVIKR-AUWJEWJLSA-N 50527943 CHEMBL4447308 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 1900 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527943&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155518942 440736525 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295174 FC(F)(F)Oc1ccc(cc1)-c1cncc(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C16H10F3N3O2S/c17-16(18,19)24-12-3-1-10(2-4-12)11-5-9(7-21-8-11)6-13-14(23)22-15(20)25-13/h1-8H,(H2,20,22,23)/b13-6- JVAKUCDDWXWGQY-MLPAPPSSSA-N 50527947 CHEMBL4443959 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527947&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155516660 440736529 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51295175 CS(=O)(=O)Nc1ccc(cc1)-c1cnc(N)c(\C=C2/SC(=N)NC2=O)c1 InChI=1S/C16H15N5O3S2/c1-26(23,24)21-12-4-2-9(3-5-12)11-6-10(14(17)19-8-11)7-13-15(22)20-16(18)25-13/h2-8,21H,1H3,(H2,17,19)(H2,18,20,22)/b13-7- BUISTUZYCBVUDY-QPEQYQDCSA-N 50527939 CHEMBL4436057 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 25000 ChEMBL 10.1021/acs.jmedchem.0c00227 10.7270/Q2SB4964 32298120 Manz, TD; Sivakumaren, SC; Ferguson, FM; Zhang, T; Yasgar, A; Seo, HS; Ficarro, SB; Card, JD; Shim, H; Miduturu, CV; Simeonov, A; Shen, M; Marto, JA; Dhe-Paganon, S; Hall, MD; Cantley, LC; Gray, NS Dana-Farber Cancer Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527939&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155511579 440736521 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448146 FC(F)(F)c1ccccc1-c1nc(NCc2cccs2)c2ccccc2n1 InChI=1S/C20H14F3N3S/c21-20(22,23)16-9-3-1-7-14(16)19-25-17-10-4-2-8-15(17)18(26-19)24-12-13-6-5-11-27-13/h1-11H,12H2,(H,24,25,26) QBDAEJRHUCSSPR-UHFFFAOYSA-N 50497347 CHEMBL1529478 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50497347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50497347&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 3235425 433964612 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448147 C(Nc1nc(nc2ccccc12)-c1ccccc1)c1cccs1 InChI=1S/C19H15N3S/c1-2-7-14(8-3-1)18-21-17-11-5-4-10-16(17)19(22-18)20-13-15-9-6-12-23-15/h1-12H,13H2,(H,20,21,22) FVIAQILFHHNFFE-UHFFFAOYSA-N 50033288 (2-Phenyl-quinazolin-4-yl)-thiophen-2-ylmethyl-amine::CHEMBL116890 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50033288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50033288&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 2471983 103941605 CHEMBL116890 ZINC03354760 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448148 Cc1ccccc1-c1nc(NCc2cccs2)c2ccccc2n1 InChI=1S/C20H17N3S/c1-14-7-2-3-9-16(14)20-22-18-11-5-4-10-17(18)19(23-20)21-13-15-8-6-12-24-15/h2-12H,13H2,1H3,(H,21,22,23) SZOWAIVUSZXVEK-UHFFFAOYSA-N 50584981 CHEMBL1394113 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584981&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 3234199 476021068 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448149 COc1ccccc1-c1nc(NCc2cccs2)c2ccccc2n1 InChI=1S/C20H17N3OS/c1-24-18-11-5-3-9-16(18)20-22-17-10-4-2-8-15(17)19(23-20)21-13-14-7-6-12-25-14/h2-12H,13H2,1H3,(H,21,22,23) PSIXJUPVCCEAQP-UHFFFAOYSA-N 50584982 CHEMBL1479741 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584982&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 3232651 476021069 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448150 FC(F)(F)c1ccccc1-c1nc(NCC2CCCCC2)c2ccccc2n1 InChI=1S/C22H22F3N3/c23-22(24,25)18-12-6-4-10-16(18)21-27-19-13-7-5-11-17(19)20(28-21)26-14-15-8-2-1-3-9-15/h4-7,10-13,15H,1-3,8-9,14H2,(H,26,27,28) FAWADAPHCYKKBZ-UHFFFAOYSA-N 50584983 CHEMBL5083347 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584983&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166629852 476021070 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448151 FC(F)(F)c1ccccc1-c1nc(NCc2ccccc2)c2ccccc2n1 InChI=1S/C22H16F3N3/c23-22(24,25)18-12-6-4-10-16(18)21-27-19-13-7-5-11-17(19)20(28-21)26-14-15-8-2-1-3-9-15/h1-13H,14H2,(H,26,27,28) XSLPKHQATHBXTP-UHFFFAOYSA-N 50497353 CHEMBL3356099 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50497353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50497353&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 49853223 433964618 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448152 FC(F)(F)c1ccccc1-c1nc(NCc2ccccn2)c2ccccc2n1 InChI=1S/C21H15F3N4/c22-21(23,24)17-10-3-1-8-15(17)20-27-18-11-4-2-9-16(18)19(28-20)26-13-14-7-5-6-12-25-14/h1-12H,13H2,(H,26,27,28) IQBUXPXVLFMNFO-UHFFFAOYSA-N 50584984 CHEMBL5079093 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584984&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166627533 476021071 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448153 CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2ccccc2n1 InChI=1S/C23H22N4/c1-16(2)18-10-3-4-11-19(18)23-26-21-13-6-5-12-20(21)22(27-23)25-15-17-9-7-8-14-24-17/h3-14,16H,15H2,1-2H3,(H,25,26,27) QXHQVQKQUHRYAU-UHFFFAOYSA-N 50584985 CHEMBL5083265 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584985&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166630261 476021072 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448154 CC(C)c1ccccc1-c1nc(NC(C)c2ccccn2)c2ccccc2n1 InChI=1S/C24H24N4/c1-16(2)18-10-4-5-11-19(18)23-27-22-14-7-6-12-20(22)24(28-23)26-17(3)21-13-8-9-15-25-21/h4-17H,1-3H3,(H,26,27,28) VHLARDMBCMULRZ-UHFFFAOYSA-N 50584986 CHEMBL5069855 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584986&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166625785 476021073 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448155 CC(C)c1ccccc1-c1ncc(C)c(NCc2ccccn2)n1 InChI=1S/C20H22N4/c1-14(2)17-9-4-5-10-18(17)20-22-12-15(3)19(24-20)23-13-16-8-6-7-11-21-16/h4-12,14H,13H2,1-3H3,(H,22,23,24) FQGVEPGQQNEMLV-UHFFFAOYSA-N 50584987 CHEMBL5076920 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584987&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166625875 476021074 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448156 Cc1cnc(nc1NCc1ccccn1)-c1ccccc1C(F)(F)F InChI=1S/C18H15F3N4/c1-12-10-23-17(14-7-2-3-8-15(14)18(19,20)21)25-16(12)24-11-13-6-4-5-9-22-13/h2-10H,11H2,1H3,(H,23,24,25) HLMGQPAUGBTDMN-UHFFFAOYSA-N 50584988 CHEMBL5090399 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584988&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166634679 476021075 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448157 CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2ncccc2n1 InChI=1S/C22H21N5/c1-15(2)17-9-3-4-10-18(17)21-26-19-11-7-13-24-20(19)22(27-21)25-14-16-8-5-6-12-23-16/h3-13,15H,14H2,1-2H3,(H,25,26,27) JQFZVOONUHIJMR-UHFFFAOYSA-N 50584989 CHEMBL5084764 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584989 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584989&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166631252 476021076 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448158 CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2cccnc2n1 InChI=1S/C22H21N5/c1-15(2)17-9-3-4-10-18(17)22-26-20-19(11-7-13-24-20)21(27-22)25-14-16-8-5-6-12-23-16/h3-13,15H,14H2,1-2H3,(H,24,25,26,27) KWPSINQLKKYKID-UHFFFAOYSA-N 50584990 CHEMBL5077419 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584990&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166625980 476021077 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448159 FC(F)(F)c1ccccc1-c1nc(NCc2ccccn2)c2cccnc2n1 InChI=1S/C20H14F3N5/c21-20(22,23)16-9-2-1-7-14(16)19-27-17-15(8-5-11-25-17)18(28-19)26-12-13-6-3-4-10-24-13/h1-11H,12H2,(H,25,26,27,28) FRGQEMIIURMZPE-UHFFFAOYSA-N 50584991 CHEMBL5077987 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584991&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166628687 476021078 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448160 CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2n(C)ccc2n1 InChI=1S/C22H23N5/c1-15(2)17-9-4-5-10-18(17)21-25-19-11-13-27(3)20(19)22(26-21)24-14-16-8-6-7-12-23-16/h4-13,15H,14H2,1-3H3,(H,24,25,26) XIEZMAUGHWKZDR-UHFFFAOYSA-N 50584992 CHEMBL5085734 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584992&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search DVF 7QIE,7QPN 163321784 476021079 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448161 CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2[nH]ccc2n1 InChI=1S/C21H21N5/c1-14(2)16-8-3-4-9-17(16)20-25-18-10-12-23-19(18)21(26-20)24-13-15-7-5-6-11-22-15/h3-12,14,23H,13H2,1-2H3,(H,24,25,26) ISRWRXOFNJZJEE-UHFFFAOYSA-N 50584993 CHEMBL5092753 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens <25119 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584993&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166633034 476021080 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448208 CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2n(C)ccc2n1 InChI=1S/C22H23N5/c1-15(2)17-9-4-5-10-18(17)21-25-19-11-13-27(3)20(19)22(26-21)24-14-16-8-6-7-12-23-16/h4-13,15H,14H2,1-3H3,(H,24,25,26) XIEZMAUGHWKZDR-UHFFFAOYSA-N 50584992 CHEMBL5085734 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >30000 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50584992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50584992&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search DVF 7QIE,7QPN 163321784 476021079 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51448214 CS(=O)(=O)Nc1ccc(cc1)-c1cncc(c1)-c1cccc2[nH]ccc12 InChI=1S/C20H17N3O2S/c1-26(24,25)23-17-7-5-14(6-8-17)15-11-16(13-21-12-15)18-3-2-4-20-19(18)9-10-22-20/h2-13,22-23H,1H3 KKMZWHRTQLNOCF-UHFFFAOYSA-N 50527929 CHEMBL4455633 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 22000 ChEMBL 10.1021/acs.jmedchem.1c01819 10.7270/Q2SQ9493 35148092 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50527929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50527929&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 155524400 440736511 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51528683 CN1C(=O)[C@@H](CC2CCCC2)N(C2CCCC2)c2nc(Nc3cc(Cl)c(O)c(Cl)c3)ncc12 InChI=1S/C24H29Cl2N5O2/c1-30-20-13-27-24(28-15-11-17(25)21(32)18(26)12-15)29-22(20)31(16-8-4-5-9-16)19(23(30)33)10-14-6-2-3-7-14/h11-14,16,19,32H,2-10H2,1H3,(H,27,28,29)/t19-/m1/s1 AEZJZTFWCDAUDF-LJQANCHMSA-N 50615191 CHEMBL5271804 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 30 ChEMBL 10.7270/Q2WD44TR 37252102 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50615191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50615191&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 146347307 494504939 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51528684 CC1(C)CN(C(=O)N1)c1ncc(C(=O)Nc2cccc(c2)C(F)(F)F)c(N)n1 InChI=1S/C17H17F3N6O2/c1-16(2)8-26(15(28)25-16)14-22-7-11(12(21)24-14)13(27)23-10-5-3-4-9(6-10)17(18,19)20/h3-7H,8H2,1-2H3,(H,23,27)(H,25,28)(H2,21,22,24) FUSNOPLQVRUIIM-UHFFFAOYSA-N 50511409 Imanixil Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 2100 ChEMBL 10.7270/Q2WD44TR 37252102 Willems, HMG; Edwards, S; Boffey, HK; Chawner, SJ; Green, C; Romero, T; Winpenny, D; Skidmore, J; Clarke, JH; Andrews, SP University of Cambridge http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511409&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 216289 440719991 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 3WZZ,3X01,3X02,3X03,3X04,6K4G,6K4H,7EM1,7EM2,7EM3,7N80,7N81 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437559 Cc1cc(ccc1Nc1ncc(Cl)c(n1)-c1cccc(c1)-c1ccccc1)S(N)(=O)=O InChI=1S/C23H19ClN4O2S/c1-15-12-19(31(25,29)30)10-11-21(15)27-23-26-14-20(24)22(28-23)18-9-5-8-17(13-18)16-6-3-2-4-7-16/h2-14H,1H3,(H2,25,29,30)(H,26,27,28) UZXUHQCWLGIDKW-UHFFFAOYSA-N 690795 US20240277852, Compound 1 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=690795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=690795&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136672 504485460 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437562 CC(=O)N(CC#N)S(=O)(=O)c1ccc(Nc2ncc(Cl)c(n2)-c2cccc(c2)-c2ccccc2)c(C)c1 InChI=1S/C27H22ClN5O3S/c1-18-15-23(37(35,36)33(14-13-29)19(2)34)11-12-25(18)31-27-30-17-24(28)26(32-27)22-10-6-9-21(16-22)20-7-4-3-5-8-20/h3-12,15-17H,14H2,1-2H3,(H,30,31,32) IVLXRYCAZLMKJR-UHFFFAOYSA-N 691383 US20240277852, Compound 2 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691383&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 172121113 504485998 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437565 CN(C(C)=O)S(=O)(=O)c1ccc(Nc2ncc(Cl)c(n2)-c2cccc(c2)-c2ccccc2)c(C)c1 InChI=1S/C26H23ClN4O3S/c1-17-14-22(35(33,34)31(3)18(2)32)12-13-24(17)29-26-28-16-23(27)25(30-26)21-11-7-10-20(15-21)19-8-5-4-6-9-19/h4-16H,1-3H3,(H,28,29,30) JKXMGQMCWPTTQC-UHFFFAOYSA-N 691384 US20240277852, Compound 3 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691384&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136682 504485999 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437568 NS(=O)(=O)c1ccc(Nc2ncc(Cl)c(n2)-c2cccc(c2)-c2ccccc2)cc1 InChI=1S/C22H17ClN4O2S/c23-20-14-25-22(26-18-9-11-19(12-10-18)30(24,28)29)27-21(20)17-8-4-7-16(13-17)15-5-2-1-3-6-15/h1-14H,(H2,24,28,29)(H,25,26,27) CZIYACFTBMLEAN-UHFFFAOYSA-N 691385 US20240277852, Compound 4 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691385 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691385&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 172121064 504486000 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437575 CC(=O)Nc1ccc(C)c(Nc2ncc(Cl)c(n2)-c2cccc(c2)-c2ccccc2)c1 InChI=1S/C25H21ClN4O/c1-16-11-12-21(28-17(2)31)14-23(16)29-25-27-15-22(26)24(30-25)20-10-6-9-19(13-20)18-7-4-3-5-8-18/h3-15H,1-2H3,(H,28,31)(H,27,29,30) VKOONHZVWYINPG-UHFFFAOYSA-N 691390 US20240277852, Compound 9 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691390&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136702 504486005 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437578 CC(=O)Nc1cncc(Nc2ncc(Cl)c(n2)-c2cccc(c2)-c2ccccc2)c1 InChI=1S/C23H18ClN5O/c1-15(30)27-19-11-20(13-25-12-19)28-23-26-14-21(24)22(29-23)18-9-5-8-17(10-18)16-6-3-2-4-7-16/h2-14H,1H3,(H,27,30)(H,26,28,29) NXFGOAZTGIAROE-UHFFFAOYSA-N 691392 US20240277852, Compound 11 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691392&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136704 504486007 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437580 Clc1cnc(Nc2cccc(NC(=O)c3ccccc3)c2)nc1-c1cccc(c1)-c1ccccc1 InChI=1S/C29H21ClN4O/c30-26-19-31-29(34-27(26)23-14-7-13-22(17-23)20-9-3-1-4-10-20)33-25-16-8-15-24(18-25)32-28(35)21-11-5-2-6-12-21/h1-19H,(H,32,35)(H,31,33,34) RFOOHSRQEOMNGR-UHFFFAOYSA-N 691393 US20240277852, Compound 12 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691393&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136671 504486008 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437582 Clc1cnc(Nc2cncc(NC(=O)c3ccccc3)c2)nc1-c1cccc(c1)-c1ccccc1 InChI=1S/C28H20ClN5O/c29-25-18-31-28(34-26(25)22-13-7-12-21(14-22)19-8-3-1-4-9-19)33-24-15-23(16-30-17-24)32-27(35)20-10-5-2-6-11-20/h1-18H,(H,32,35)(H,31,33,34) MYKILIAMKYVIFP-UHFFFAOYSA-N 691394 US20240277852, Compound 13 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691394&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136673 504486009 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437584 Clc1cnc(Nc2cncc(NC(=O)c3ccccc3)c2)nc1-c1cccc(c1)-c1cccnc1 InChI=1S/C27H19ClN6O/c28-24-17-31-27(34-25(24)20-9-4-8-19(12-20)21-10-5-11-29-14-21)33-23-13-22(15-30-16-23)32-26(35)18-6-2-1-3-7-18/h1-17H,(H,32,35)(H,31,33,34) IWGGNFYZKYPGAZ-UHFFFAOYSA-N 691395 US20240277852, Compound 14 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691395&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136676 504486010 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437586 Clc1cnc(Nc2cnc3OC[C@@H]4CCC(=O)N4c3c2)nc1-c1cccc(c1)-c1ccccc1 InChI=1S/C26H20ClN5O2/c27-21-14-29-26(31-24(21)18-8-4-7-17(11-18)16-5-2-1-3-6-16)30-19-12-22-25(28-13-19)34-15-20-9-10-23(33)32(20)22/h1-8,11-14,20H,9-10,15H2,(H,29,30,31)/t20-/m0/s1 ZPCVXEWODQKIKW-FQEVSTJZSA-N 691396 US20240277852, Compound 15 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691396&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136697 504486011 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437590 Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)c(OCCCCCCC(=O)N2CCC3(CCN(C3=O)c3cncc(Nc4ncc(Cl)c(n4)-c4cccc(c4)-c4ccccc4)c3)CC2)c1 InChI=1S/C62H70ClFN10O7S/c1-39-53(82-38-68-39)43-18-19-44(33-66-55(77)49-32-47(75)37-74(49)56(78)54(60(2,3)4)71-57(79)62(64)20-21-62)50(30-43)81-28-11-6-5-10-17-51(76)72-25-22-61(23-26-72)24-27-73(58(61)80)46-31-45(34-65-35-46)69-59-67-36-48(63)52(70-59)42-16-12-15-41(29-42)40-13-8-7-9-14-40/h7-9,12-16,18-19,29-31,34-36,38,47,49,54,75H,5-6,10-11,17,20-28,32-33,37H2,1-4H3,(H,66,77)(H,71,79)(H,67,69,70)/t47-,49+,54-/m1/s1 VCOSWEBKUXOFPA-PHCPANOJSA-N 691399 US20240277852, Compound 56 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691399&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136698 504486014 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 1437592 C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)CCCCCC(=O)N1CCC2(CCN(C2=O)c2cncc(Nc3ncc(Cl)c(n3)-c3cccc(c3)-c3ccccc3)c2)CC1)C(C)(C)C)c1ccc(cc1)-c1scnc1C InChI=1S/C59H67ClN10O6S/c1-37(39-19-21-41(22-20-39)52-38(2)63-36-77-52)64-54(74)48-31-46(71)35-70(48)55(75)53(58(3,4)5)66-49(72)17-10-7-11-18-50(73)68-26-23-59(24-27-68)25-28-69(56(59)76)45-30-44(32-61-33-45)65-57-62-34-47(60)51(67-57)43-16-12-15-42(29-43)40-13-8-6-9-14-40/h6,8-9,12-16,19-22,29-30,32-34,36-37,46,48,53,71H,7,10-11,17-18,23-28,31,35H2,1-5H3,(H,64,74)(H,66,72)(H,62,65,67)/t37-,46+,48-,53+/m0/s1 NIQFZCJNEODJTE-CSIWTOAPSA-N 691400 US20240277852, Compound 57 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 US Patent 10.7270/Q2BR8XGS US20240277852 Gray, NS; Teng, M; Wang, E; Jiang, J; Zhang, T; Cantley, LC; Fischer, ES; Donovan, KA DANA-FARBER CANCER INSTITUTE, INC.; CORNELL UNIVERSITY http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=691400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=691400&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 166136687 504486015 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51554973 CS(=O)(=O)c1ccc(Nc2ncnc3sc(cc23)-c2ccccc2)cc1 InChI=1S/C19H15N3O2S2/c1-26(23,24)15-9-7-14(8-10-15)22-18-16-11-17(13-5-3-2-4-6-13)25-19(16)21-12-20-18/h2-12H,1H3,(H,20,21,22) NNTCJFZHNHXBGF-UHFFFAOYSA-N 50625578 CHEMBL5422736 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1039/d3md00355h 10.7270/Q21N85H9 37859710 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625578&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51554974 Cn1cc(cn1)-c1cc2c(Nc3ccc(cc3)S(C)(=O)=O)ncnc2s1 InChI=1S/C17H15N5O2S2/c1-22-9-11(8-20-22)15-7-14-16(18-10-19-17(14)25-15)21-12-3-5-13(6-4-12)26(2,23)24/h3-10H,1-2H3,(H,18,19,21) GMRMVTHEWJWSDM-UHFFFAOYSA-N 50625579 CHEMBL5399032 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1039/d3md00355h 10.7270/Q21N85H9 37859710 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625579&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51554975 Cc1cnccc1-c1cc2c(Nc3ccc(cc3)S(C)(=O)=O)ncnc2s1 InChI=1S/C19H16N4O2S2/c1-12-10-20-8-7-15(12)17-9-16-18(21-11-22-19(16)26-17)23-13-3-5-14(6-4-13)27(2,24)25/h3-11H,1-2H3,(H,21,22,23) QGARYOVZZQZJNN-UHFFFAOYSA-N 50625580 CHEMBL5405402 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1039/d3md00355h 10.7270/Q21N85H9 37859710 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625580&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51554976 CS(=O)(=O)c1ccc(Nc2ncnc3sc(cc23)-c2cccnc2Cl)cc1 InChI=1S/C18H13ClN4O2S2/c1-27(24,25)12-6-4-11(5-7-12)23-17-14-9-15(26-18(14)22-10-21-17)13-3-2-8-20-16(13)19/h2-10H,1H3,(H,21,22,23) SUKVZYAWPKVSJL-UHFFFAOYSA-N 50625581 CHEMBL5427550 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1039/d3md00355h 10.7270/Q21N85H9 37859710 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625581&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51554977 Cc1ncccc1-c1cc2c(Nc3ccc(cc3)S(C)(=O)=O)ncnc2s1 InChI=1S/C19H16N4O2S2/c1-12-15(4-3-9-20-12)17-10-16-18(21-11-22-19(16)26-17)23-13-5-7-14(8-6-13)27(2,24)25/h3-11H,1-2H3,(H,21,22,23) MZCBHFVEGGXOPB-UHFFFAOYSA-N 50625582 CHEMBL5405966 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens >10000 ChEMBL 10.1039/d3md00355h 10.7270/Q21N85H9 37859710 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625582&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2 51554273 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2cc(ncn2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H29N7O2/c1-38(2)16-6-11-30(39)36-22-14-12-21(13-15-22)31(40)37-24-8-5-7-23(17-24)35-29-18-28(33-20-34-29)26-19-32-27-10-4-3-9-25(26)27/h3-15,17-20,32H,16H2,1-2H3,(H,36,39)(H,37,40)(H,33,34,35)/b11-6+ MJJJRRMQCUUKEO-IZZDOVSWSA-N 50511422 CHEMBL4446338 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Homo sapiens 5900 ChEMBL 10.1016/j.ejmech.2022.115027 10.7270/Q2MK6J8J 36584631 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004235&target=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511422&enzyme=Phosphatidylinositol+5-phosphate+4-kinase+type-2+beta&column=ki&startPg=0&Increment=50&submit=Search N51 6OSP 134451950 440720004 1 MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKKEVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT 1BO1,7EM3,7EM2,7EM1,6K4H,6K4G,3X04,3X03,3X02,3X01,3WZZ,7N81,7N80 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta PI42B_HUMAN P78356 Q5U0E8 Q8TBP2