BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50444124 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CN1CCOCC1)S(=O)(=O)c1ccccc1 InChI=1S/C24H28F3N3O6S2/c25-24(26,27)21-7-6-20(37(32,33)19-4-2-1-3-5-19)16-22(21)38(34,35)28-18-8-10-30(11-9-18)23(31)17-29-12-14-36-15-13-29/h1-7,16,18,28H,8-15,17H2 DZZDRRLIAVIQQC-UHFFFAOYSA-N 50265480 CHEMBL523726::N-[1-(Morpholin-4-ylacetyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 160 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265480&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185178 104113240 CHEMBL523726 ZINC42891049 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444125 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CN1CCNCC1)S(=O)(=O)c1ccccc1 InChI=1S/C24H29F3N4O5S2/c25-24(26,27)21-7-6-20(37(33,34)19-4-2-1-3-5-19)16-22(21)38(35,36)29-18-8-12-31(13-9-18)23(32)17-30-14-10-28-11-15-30/h1-7,16,18,28-29H,8-15,17H2 KHJCNXWNUWJMQA-UHFFFAOYSA-N 50265481 5-(Phenylsulfonyl)-N-[1-(piperazin-1-ylacetyl)piperidin-4-yl]-2-(trifluoro-methyl)benzenesulfonamide::CHEMBL525718 Proto-oncogene Wnt-3 Homo sapiens 250 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265481&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25186293 104113241 CHEMBL525718 ZINC42919966 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444126 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)Cn1ccnc1)S(=O)(=O)c1ccccc1 InChI=1S/C23H23F3N4O5S2/c24-23(25,26)20-7-6-19(36(32,33)18-4-2-1-3-5-18)14-21(20)37(34,35)28-17-8-11-30(12-9-17)22(31)15-29-13-10-27-16-29/h1-7,10,13-14,16-17,28H,8-9,11-12,15H2 UEBXCNMAUOGYOC-UHFFFAOYSA-N 50265499 CHEMBL495534::N-[1-(1H-Imidazol-1-ylacetyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 230 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265499&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185179 104113252 CHEMBL495534 ZINC49881517 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444127 CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-43(39,40)24-18-21(11-12-22(24)28(29,30)31)42(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m0/s1 FCXCNDHEICKHMB-QHCPKHFHSA-N 50265500 (S)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluoromethyl)phenylsulfonamido)piperidine-1-carbonyl)pyrrolidine-1-carboxylate::CHEMBL449276::tert-Butyl (2S)-2-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]-sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxylate Proto-oncogene Wnt-3 Homo sapiens 60 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265500&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185180 104113253 CHEMBL449276 ZINC49833580 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444128 CC(C)(C)OC(=O)N1CCC[C@@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H34F3N3O7S2/c1-27(2,3)41-26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-43(39,40)24-18-21(11-12-22(24)28(29,30)31)42(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m1/s1 FCXCNDHEICKHMB-HSZRJFAPSA-N 50265501 (R)-tert-butyl 2-(4-(5-(phenylsulfonyl)-2-(trifluoromethyl)phenylsulfonamido)piperidine-1-carbonyl)pyrrolidine-1-carboxylate::CHEMBL372397::tert-Butyl (2R)-2-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxylate Proto-oncogene Wnt-3 Homo sapiens 210 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265501&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25186835 104113254 CHEMBL372397 ZINC49776240 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444129 CC(C)(C)OC(=O)N1[C@@H](CCC1=O)C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H32F3N3O8S2/c1-27(2,3)42-26(37)34-22(11-12-24(34)35)25(36)33-15-13-18(14-16-33)32-44(40,41)23-17-20(9-10-21(23)28(29,30)31)43(38,39)19-7-5-4-6-8-19/h4-10,17-18,22,32H,11-16H2,1-3H3/t22-/m0/s1 AFFKILKRCQTYFJ-QFIPXVFZSA-N 50265502 CHEMBL504979::tert-Butyl(5S)-2-oxo-5-{[4-({[5-(Phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxylate Proto-oncogene Wnt-3 Homo sapiens 90 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265502&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185446 104113255 CHEMBL504979 ZINC49898270 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444130 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1)S(=O)(=O)c1ccccc1 InChI=1S/C23H26F3N3O5S2/c24-23(25,26)19-9-8-18(35(31,32)17-5-2-1-3-6-17)15-21(19)36(33,34)28-16-10-13-29(14-11-16)22(30)20-7-4-12-27-20/h1-3,5-6,8-9,15-16,20,27-28H,4,7,10-14H2/t20-/m0/s1 CUKVPVAQKUDUCX-FQEVSTJZSA-N 50265503 (S)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide::5-(Phenylsulfonyl)-N-(1-L-prolylpiperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide::CHEMBL495535 Proto-oncogene Wnt-3 Homo sapiens 350 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265503&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185448 104113256 CHEMBL495535 ZINC49881518 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444131 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@H]1CCCN1)S(=O)(=O)c1ccccc1 InChI=1S/C23H26F3N3O5S2/c24-23(25,26)19-9-8-18(35(31,32)17-5-2-1-3-6-17)15-21(19)36(33,34)28-16-10-13-29(14-11-16)22(30)20-7-4-12-27-20/h1-3,5-6,8-9,15-16,20,27-28H,4,7,10-14H2/t20-/m1/s1 CUKVPVAQKUDUCX-HXUWFJFHSA-N 50265504 (R)-5-(phenylsulfonyl)-N-(1-(pyrrolidine-2-carbonyl)piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide::5-(Phenylsulfonyl)-N-(1-D-prolylpiperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide::CHEMBL495536 Proto-oncogene Wnt-3 Homo sapiens 710 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265504&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185450 104113257 CHEMBL495536 ZINC49881519 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444132 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCC(=O)N1)S(=O)(=O)c1ccccc1 InChI=1S/C23H24F3N3O6S2/c24-23(25,26)18-7-6-17(36(32,33)16-4-2-1-3-5-16)14-20(18)37(34,35)28-15-10-12-29(13-11-15)22(31)19-8-9-21(30)27-19/h1-7,14-15,19,28H,8-13H2,(H,27,30)/t19-/m0/s1 QEZJBOCRIJFLSU-IBGZPJMESA-N 50265505 CHEMBL525899::N-[1-(5-oxo-L-Prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 240 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265505&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25187113 104113258 CHEMBL525899 ZINC42921313 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444133 CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C25H28F3N3O6S2/c1-17(32)31-13-5-8-22(31)24(33)30-14-11-18(12-15-30)29-39(36,37)23-16-20(9-10-21(23)25(26,27)28)38(34,35)19-6-3-2-4-7-19/h2-4,6-7,9-10,16,18,22,29H,5,8,11-15H2,1H3/t22-/m0/s1 OFNCRSCSSBSRLH-QFIPXVFZSA-N 50265544 CHEMBL525970::N-[1-(1-Acetyl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 250 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265544&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185451 104113280 CHEMBL525970 ZINC42919970 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444134 CC(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H32F3N3O6S2/c1-18(2)25(34)33-14-6-9-23(33)26(35)32-15-12-19(13-16-32)31-41(38,39)24-17-21(10-11-22(24)27(28,29)30)40(36,37)20-7-4-3-5-8-20/h3-5,7-8,10-11,17-19,23,31H,6,9,12-16H2,1-2H3/t23-/m0/s1 JFPHZEPZNXSNSJ-QHCPKHFHSA-N 50265545 CHEMBL500903::N-[1-(1-Isobutyryl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 90 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265545&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25187114 104113281 CHEMBL500903 ZINC42807021 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444135 CC(C)(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H34F3N3O6S2/c1-27(2,3)26(36)34-15-7-10-23(34)25(35)33-16-13-19(14-17-33)32-42(39,40)24-18-21(11-12-22(24)28(29,30)31)41(37,38)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,32H,7,10,13-17H2,1-3H3/t23-/m0/s1 JFLCMQLJIGPPDH-QHCPKHFHSA-N 50265546 CHEMBL447079::N-{1-[1-(2,2-Dimethylpropanoyl)-L-prolyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 270 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265546&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185452 104113282 CHEMBL447079 ZINC44281287 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444136 CC(C)(C)CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H36F3N3O6S2/c1-28(2,3)19-26(36)35-15-7-10-24(35)27(37)34-16-13-20(14-17-34)33-43(40,41)25-18-22(11-12-23(25)29(30,31)32)42(38,39)21-8-5-4-6-9-21/h4-6,8-9,11-12,18,20,24,33H,7,10,13-17,19H2,1-3H3/t24-/m0/s1 WNOXBWBWUOWWNS-DEOSSOPVSA-N 50265547 CHEMBL455476::N-{1-[1-(3,3-Dimethylbutanoyl)-L-prolyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 120 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265547&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25187115 104113283 CHEMBL455476 ZINC49841383 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444137 CN(C)CC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C27H33F3N4O6S2/c1-32(2)18-25(35)34-14-6-9-23(34)26(36)33-15-12-19(13-16-33)31-42(39,40)24-17-21(10-11-22(24)27(28,29)30)41(37,38)20-7-4-3-5-8-20/h3-5,7-8,10-11,17,19,23,31H,6,9,12-16,18H2,1-2H3/t23-/m0/s1 CVIGLQTTWLTQEY-QHCPKHFHSA-N 50265548 CHEMBL501332::N-[1-(N,N-Dimethylglycyl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 310 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265548&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185742 104113284 CHEMBL501332 ZINC42808857 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444138 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)C1CCCCC1)S(=O)(=O)c1ccccc1 InChI=1S/C30H36F3N3O6S2/c31-30(32,33)25-14-13-24(43(39,40)23-10-5-2-6-11-23)20-27(25)44(41,42)34-22-15-18-35(19-16-22)29(38)26-12-7-17-36(26)28(37)21-8-3-1-4-9-21/h2,5-6,10-11,13-14,20-22,26,34H,1,3-4,7-9,12,15-19H2/t26-/m0/s1 UEYJJECWJGJDKU-SANMLTNESA-N 50265549 CHEMBL507695::N-{1-[1-(Cyclohexylcarbonyl)-L-prolyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 460 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265549&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25187116 104113285 CHEMBL507695 ZINC49898598 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444139 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)c1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C30H30F3N3O6S2/c31-30(32,33)25-14-13-24(43(39,40)23-10-5-2-6-11-23)20-27(25)44(41,42)34-22-15-18-35(19-16-22)29(38)26-12-7-17-36(26)28(37)21-8-3-1-4-9-21/h1-6,8-11,13-14,20,22,26,34H,7,12,15-19H2/t26-/m0/s1 LXMVIRZQJKZCNH-SANMLTNESA-N 50265550 CHEMBL510748::N-[1-(1-Benzoyl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 380 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265550&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185743 104113286 CHEMBL510748 ZINC49899454 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444140 CN(C)c1ccc(cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C32H35F3N4O6S2/c1-37(2)24-12-10-22(11-13-24)30(40)39-18-6-9-28(39)31(41)38-19-16-23(17-20-38)36-47(44,45)29-21-26(14-15-27(29)32(33,34)35)46(42,43)25-7-4-3-5-8-25/h3-5,7-8,10-15,21,23,28,36H,6,9,16-20H2,1-2H3/t28-/m0/s1 IXLRWKPASUYBNA-NDEPHWFRSA-N 50265551 CHEMBL462363::N-(1-{1-[4-(Dimethylamino)benzoyl]-L-prolyl}piperidin-4-yl)-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 830 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265551&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185744 104113287 CHEMBL462363 ZINC49850476 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444141 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)c1ccncc1)S(=O)(=O)c1ccccc1 InChI=1S/C29H29F3N4O6S2/c30-29(31,32)24-9-8-23(43(39,40)22-5-2-1-3-6-22)19-26(24)44(41,42)34-21-12-17-35(18-13-21)28(38)25-7-4-16-36(25)27(37)20-10-14-33-15-11-20/h1-3,5-6,8-11,14-15,19,21,25,34H,4,7,12-13,16-18H2/t25-/m0/s1 WAWYMBXODUTKBX-VWLOTQADSA-N 50265552 CHEMBL454478::N-[1-(1-Isonicotinoyl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 350 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265552&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25187401 104113288 CHEMBL454478 ZINC49841323 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444142 CCNC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H31F3N4O6S2/c1-2-30-25(35)33-14-6-9-22(33)24(34)32-15-12-18(13-16-32)31-41(38,39)23-17-20(10-11-21(23)26(27,28)29)40(36,37)19-7-4-3-5-8-19/h3-5,7-8,10-11,17-18,22,31H,2,6,9,12-16H2,1H3,(H,30,35)/t22-/m0/s1 XIZVLGVGWZCHHV-QFIPXVFZSA-N 50265553 (2S)-N-Ethyl-2-{[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxamide::CHEMBL527086 Proto-oncogene Wnt-3 Homo sapiens 90 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265553&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185745 104113289 CHEMBL527086 ZINC42919858 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444143 CC(C)(C)NC(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C28H35F3N4O6S2/c1-27(2,3)32-26(37)35-15-7-10-23(35)25(36)34-16-13-19(14-17-34)33-43(40,41)24-18-21(11-12-22(24)28(29,30)31)42(38,39)20-8-5-4-6-9-20/h4-6,8-9,11-12,18-19,23,33H,7,10,13-17H2,1-3H3,(H,32,37)/t23-/m0/s1 IVGIETSLCFMRPI-QHCPKHFHSA-N 50265554 (2S)-N-(tert-Butyl)-2-{[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxamide::CHEMBL503825 Proto-oncogene Wnt-3 Homo sapiens 30 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265554&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25138833 104113290 CHEMBL503825 ZINC49898258 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444144 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)Nc1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C30H31F3N4O6S2/c31-30(32,33)25-14-13-24(44(40,41)23-10-5-2-6-11-23)20-27(25)45(42,43)35-22-15-18-36(19-16-22)28(38)26-12-7-17-37(26)29(39)34-21-8-3-1-4-9-21/h1-6,8-11,13-14,20,22,26,35H,7,12,15-19H2,(H,34,39)/t26-/m0/s1 XVNXQYZVQVAWDS-SANMLTNESA-N 50265555 (2S)-N-Phenyl-2-{[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)-phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxamide::CHEMBL452196 Proto-oncogene Wnt-3 Homo sapiens 310 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265555&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25186013 104113291 CHEMBL452196 ZINC49841276 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444145 CN(C)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C26H31F3N4O6S2/c1-31(2)25(35)33-14-6-9-22(33)24(34)32-15-12-18(13-16-32)30-41(38,39)23-17-20(10-11-21(23)26(27,28)29)40(36,37)19-7-4-3-5-8-19/h3-5,7-8,10-11,17-18,22,30H,6,9,12-16H2,1-2H3/t22-/m0/s1 SCZIDLPYDKQSDR-QFIPXVFZSA-N 50265580 (2S)-N,N-Dimethyl-2-{[4-({[5-(phenylsulfonyl)-2-(trifluoromethyl)phenyl]sulfonyl}amino)piperidin-1-yl]carbonyl}pyrrolidine-1-carboxamide::CHEMBL501433 Proto-oncogene Wnt-3 Homo sapiens 160 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265580&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25187402 104113300 CHEMBL501433 ZINC42804065 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444146 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)N1CCOCC1)S(=O)(=O)c1ccccc1 InChI=1S/C28H33F3N4O7S2/c29-28(30,31)23-9-8-22(43(38,39)21-5-2-1-3-6-21)19-25(23)44(40,41)32-20-10-13-33(14-11-20)26(36)24-7-4-12-35(24)27(37)34-15-17-42-18-16-34/h1-3,5-6,8-9,19-20,24,32H,4,7,10-18H2/t24-/m0/s1 RIBOGOWWMKNBLE-DEOSSOPVSA-N 50265581 CHEMBL505036::N-{1-[1-(Morpholin-4-ylcarbonyl)-L-prolyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 280 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265581&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25186014 104113301 CHEMBL505036 ZINC49898820 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444147 CN1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C24H28F3N3O5S2/c1-29-13-5-8-21(29)23(31)30-14-11-17(12-15-30)28-37(34,35)22-16-19(9-10-20(22)24(25,26)27)36(32,33)18-6-3-2-4-7-18/h2-4,6-7,9-10,16-17,21,28H,5,8,11-15H2,1H3/t21-/m0/s1 KFRQUJGHHZKEBM-NRFANRHFSA-N 50265582 CHEMBL496581::N-[1-(1-Methyl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 230 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265582&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25186559 104113302 CHEMBL496581 ZINC49881932 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444148 CC(C)(C)CCN1CCC[C@H]1C(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C29H38F3N3O5S2/c1-28(2,3)15-19-34-16-7-10-25(34)27(36)35-17-13-21(14-18-35)33-42(39,40)26-20-23(11-12-24(26)29(30,31)32)41(37,38)22-8-5-4-6-9-22/h4-6,8-9,11-12,20-21,25,33H,7,10,13-19H2,1-3H3/t25-/m0/s1 NRLJWPWRBPODBR-VWLOTQADSA-N 50265583 CHEMBL451431::N-{1-[1-(3,3-Dimethylbutyl)-L-prolyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 450 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265583&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25186015 104113303 CHEMBL451431 ZINC44352075 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444149 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1CC1CCCCC1)S(=O)(=O)c1ccccc1 InChI=1S/C30H38F3N3O5S2/c31-30(32,33)26-14-13-25(42(38,39)24-10-5-2-6-11-24)20-28(26)43(40,41)34-23-15-18-35(19-16-23)29(37)27-12-7-17-36(27)21-22-8-3-1-4-9-22/h2,5-6,10-11,13-14,20,22-23,27,34H,1,3-4,7-9,12,15-19,21H2/t27-/m0/s1 QWHSQMJRLKQTCQ-MHZLTWQESA-N 50265584 CHEMBL503281::N-{1-[1-(Cyclohexylmethyl)-L-prolyl]piperidin-4-yl}-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 320 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265584&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25186016 104113304 CHEMBL503281 ZINC49889083 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444150 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)[C@@H]1CCCN1Cc1ccccc1)S(=O)(=O)c1ccccc1 InChI=1S/C30H32F3N3O5S2/c31-30(32,33)26-14-13-25(42(38,39)24-10-5-2-6-11-24)20-28(26)43(40,41)34-23-15-18-35(19-16-23)29(37)27-12-7-17-36(27)21-22-8-3-1-4-9-22/h1-6,8-11,13-14,20,23,27,34H,7,12,15-19,21H2/t27-/m0/s1 SGJFKFRGJLVMQE-MHZLTWQESA-N 50265585 CHEMBL511077::N-[1-(1-Benzyl-L-prolyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 720 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265585&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25186562 104113305 CHEMBL511077 ZINC49899460 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444151 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCNCC1)S(=O)(=O)c1ccccc1 InChI=1S/C18H19F3N2O4S2/c19-18(20,21)16-7-6-15(28(24,25)14-4-2-1-3-5-14)12-17(16)29(26,27)23-13-8-10-22-11-9-13/h1-7,12-13,22-23H,8-11H2 ITBGJNVZJBVPLJ-UHFFFAOYSA-N 50265467 5-(Phenylsulfonyl)-N-piperidin-4-yl-2-(trifluoromethyl)benzenesulfonamide::5-(phenylsulfonyl)-N-(piperidin-4-yl)-2-(trifluoromethyl)benzenesulfonamide::CHEMBL495575::WAY-316606 Proto-oncogene Wnt-3 Homo sapiens 650 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265467&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 16727102 104113231 CHEMBL495575 ZINC40955762 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444152 CNCC(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C21H24F3N3O5S2/c1-25-14-20(28)27-11-9-15(10-12-27)26-34(31,32)19-13-17(7-8-18(19)21(22,23)24)33(29,30)16-5-3-2-4-6-16/h2-8,13,15,25-26H,9-12,14H2,1H3 QRRRFXRYQZQTNR-UHFFFAOYSA-N 50265468 CHEMBL497177::N-[1-(N-Methylglycyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoromethyl)-benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 620 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265468&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185176 104113232 CHEMBL497177 ZINC40973856 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444153 CN(C)CC(=O)N1CCC(CC1)NS(=O)(=O)c1cc(ccc1C(F)(F)F)S(=O)(=O)c1ccccc1 InChI=1S/C22H26F3N3O5S2/c1-27(2)15-21(29)28-12-10-16(11-13-28)26-35(32,33)20-14-18(8-9-19(20)22(23,24)25)34(30,31)17-6-4-3-5-7-17/h3-9,14,16,26H,10-13,15H2,1-2H3 NVMIMPZDKGYUQC-UHFFFAOYSA-N 50265469 CHEMBL497383::N-[1-(N,N-Dimethylglycyl)piperidin-4-yl]-5-(phenylsulfonyl)-2-(trifluoro-methyl)benzenesulfonamide Proto-oncogene Wnt-3 Homo sapiens 280 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265469&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25185177 104113233 CHEMBL497383 ZINC49881783 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50444154 FC(F)(F)c1ccc(cc1S(=O)(=O)NC1CCN(CC1)C(=O)CN1CCCC1)S(=O)(=O)c1ccccc1 InChI=1S/C24H28F3N3O5S2/c25-24(26,27)21-9-8-20(36(32,33)19-6-2-1-3-7-19)16-22(21)37(34,35)28-18-10-14-30(15-11-18)23(31)17-29-12-4-5-13-29/h1-3,6-9,16,18,28H,4-5,10-15,17H2 HRJIEWRZLGFGAR-UHFFFAOYSA-N 50265479 5-(Phenylsulfonyl)-N-[1-(pyrrolidin-1-ylacetyl)piperidin-4-yl]-2-(trifluoro-methyl)benzenesulfonamide::CHEMBL495526 Proto-oncogene Wnt-3 Homo sapiens 190 ChEMBL 10.1021/jm801144h 10.7270/Q2NZ87HT 19072540 Moore, WJ; Kern, JC; Bhat, R; Commons, TJ; Fukayama, S; Goljer, I; Krishnamurthy, G; Magolda, RL; Nogle, L; Pitts, K; Stauffer, B; Trybulski, EJ; Welmaker, GS; Wilson, M; Bodine, PV Wyeth Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50265479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50265479&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 25186291 104113239 CHEMBL495526 ZINC49881516 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509833 Cc1ccc2cccnc2c1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O InChI=1S/C26H21N3O3/c1-14-4-5-15-3-2-12-27-23(15)22(14)28-24(30)16-8-10-19(11-9-16)29-25(31)20-17-6-7-18(13-17)21(20)26(29)32/h2-12,17-18,31-32H,13H2,1H3,(H,28,30)/t17-,18+ IDGGHACGZPRUBM-HDICACEKSA-N 50294787 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(7-methyl-quinolin-8-yl)-benzamide::CHEMBL564714 Proto-oncogene Wnt-3 Homo sapiens 800 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294787&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934247 104136318 CHEMBL564714 ZINC62178733 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509834 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NC1CCCc2cccnc12 InChI=1S/C25H23N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h2,4,6-12,16-17,19,30-31H,1,3,5,13H2,(H,27,29)/t16-,17+,19? YLOMGERBNLRWBO-JJTKIYQPSA-N 50294788 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(5,6,7,8-tetrahydro-quinolin-8-yl)-benzamide::CHEMBL563969 Proto-oncogene Wnt-3 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294788&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934248 104136319 CHEMBL563969 ZINC62178741 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509835 COc1ccccc1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O InChI=1S/C23H20N2O4/c1-29-18-5-3-2-4-17(18)24-21(26)13-8-10-16(11-9-13)25-22(27)19-14-6-7-15(12-14)20(19)23(25)28/h2-11,14-15,27-28H,12H2,1H3,(H,24,26)/t14-,15+ IWVCEVICQJXFTR-GASCZTMLSA-N 50294789 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(2-methoxy-phenyl)-benzamide::CHEMBL550442 Proto-oncogene Wnt-3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294789&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934249 104136320 CHEMBL550442 ZINC04843896 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509836 Oc1c2[C@@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccccc1 InChI=1S/C22H18N2O3/c25-20(23-16-4-2-1-3-5-16)13-8-10-17(11-9-13)24-21(26)18-14-6-7-15(12-14)19(18)22(24)27/h1-11,14-15,26-27H,12H2,(H,23,25)/t14-,15-/m0/s1 LEELBCVWRZWEHN-GJZGRUSLSA-N 50294790 4-((1R,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-phenyl-benzamide::CHEMBL562944 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294790&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934250 104136321 CHEMBL562944 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509837 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccccc1F InChI=1S/C22H17FN2O3/c23-16-3-1-2-4-17(16)24-20(26)12-7-9-15(10-8-12)25-21(27)18-13-5-6-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+ IWJYSRJQRGOBPQ-OKILXGFUSA-N 50294791 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(2-fluoro-phenyl)-benzamide::CHEMBL558300 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294791&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934251 104136322 CHEMBL558300 ZINC62178745 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509838 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccccc1Cl InChI=1S/C22H17ClN2O3/c23-16-3-1-2-4-17(16)24-20(26)12-7-9-15(10-8-12)25-21(27)18-13-5-6-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+ WAXKRURKHONNJB-OKILXGFUSA-N 50294792 CHEMBL550569::N-(2-Chloro-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294792&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934252 104136323 CHEMBL550569 ZINC04836954 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509839 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccccc1Br InChI=1S/C22H17BrN2O3/c23-16-3-1-2-4-17(16)24-20(26)12-7-9-15(10-8-12)25-21(27)18-13-5-6-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+ QTDVRGYSLIZOGT-OKILXGFUSA-N 50294793 CHEMBL565166::N-(2-Bromo-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294793&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934253 104136324 CHEMBL565166 ZINC43011535 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509840 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc(F)c1 InChI=1S/C22H17FN2O3/c23-15-2-1-3-16(11-15)24-20(26)12-6-8-17(9-7-12)25-21(27)18-13-4-5-14(10-13)19(18)22(25)28/h1-9,11,13-14,27-28H,10H2,(H,24,26)/t13-,14+ JWFUGNXQGLGJBJ-OKILXGFUSA-N 50294794 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(3-fluoro-phenyl)-benzamide::CHEMBL565052 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294794&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934254 104136325 CHEMBL565052 ZINC62178747 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509841 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc(Cl)c1 InChI=1S/C22H17ClN2O3/c23-15-2-1-3-16(11-15)24-20(26)12-6-8-17(9-7-12)25-21(27)18-13-4-5-14(10-13)19(18)22(25)28/h1-9,11,13-14,27-28H,10H2,(H,24,26)/t13-,14+ QSPDCKYNSLAGBQ-OKILXGFUSA-N 50294795 CHEMBL565180::N-(3-Chloro-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294795&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934255 104136326 CHEMBL565180 ZINC06331239 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509842 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc(Br)c1 InChI=1S/C22H17BrN2O3/c23-15-2-1-3-16(11-15)24-20(26)12-6-8-17(9-7-12)25-21(27)18-13-4-5-14(10-13)19(18)22(25)28/h1-9,11,13-14,27-28H,10H2,(H,24,26)/t13-,14+ WNLMCYAUPVMAIM-OKILXGFUSA-N 50294796 CHEMBL552187::N-(3-Bromo-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 9000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294796&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934256 104136327 CHEMBL552187 ZINC43064159 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509843 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(F)cc1 InChI=1S/C22H17FN2O3/c23-15-5-7-16(8-6-15)24-20(26)12-3-9-17(10-4-12)25-21(27)18-13-1-2-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+ XSWAILVGDDEFSA-OKILXGFUSA-N 50294797 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(4-fluoro-phenyl)-benzamide::CHEMBL550764 Proto-oncogene Wnt-3 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294797&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934257 104136328 CHEMBL550764 ZINC06332313 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509844 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1 InChI=1S/C22H17ClN2O3/c23-15-5-7-16(8-6-15)24-20(26)12-3-9-17(10-4-12)25-21(27)18-13-1-2-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+ LPGXJEROXWXJJV-OKILXGFUSA-N 50294798 CHEMBL560712::N-(4-Chloro-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 3000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294798&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934258 104136329 CHEMBL560712 ZINC05894384 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509845 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Br)cc1 InChI=1S/C22H17BrN2O3/c23-15-5-7-16(8-6-15)24-20(26)12-3-9-17(10-4-12)25-21(27)18-13-1-2-14(11-13)19(18)22(25)28/h1-10,13-14,27-28H,11H2,(H,24,26)/t13-,14+ IPRSASNSKSMYDH-OKILXGFUSA-N 50294799 CHEMBL551249::N-(4-Bromo-phenyl)-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294799&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934259 104136330 CHEMBL551249 ZINC09438741 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509846 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc(F)c1F InChI=1S/C22H16F2N2O3/c23-15-2-1-3-16(19(15)24)25-20(27)11-6-8-14(9-7-11)26-21(28)17-12-4-5-13(10-12)18(17)22(26)29/h1-9,12-13,28-29H,10H2,(H,25,27)/t12-,13+ LOGHBDGEVFFBQT-BETUJISGSA-N 50294800 CHEMBL563347::N-(2,3-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294800&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934260 104136331 CHEMBL563347 ZINC43072510 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509847 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(F)cc1F InChI=1S/C22H16F2N2O3/c23-14-5-8-17(16(24)10-14)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+ LQUHLBYQPGSVFO-BETUJISGSA-N 50294801 CHEMBL550093::N-(2,4-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 9000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294801&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934261 104136332 CHEMBL550093 ZINC43011323 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509848 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Cl)cc1Cl InChI=1S/C22H16Cl2N2O3/c23-14-5-8-17(16(24)10-14)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+ UZRGFNIMVXYVHP-BETUJISGSA-N 50294802 CHEMBL561779::N-(2,4-Dichloro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294802&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934262 104136333 CHEMBL561779 ZINC35338771 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509849 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Br)cc1Br InChI=1S/C22H16Br2N2O3/c23-14-5-8-17(16(24)10-14)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+ BNWKSXWTWMRUDU-BETUJISGSA-N 50294803 CHEMBL549767::N-(2,4-Dibromo-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294803&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934263 104136334 CHEMBL549767 ZINC70631562 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509850 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cc(F)ccc1F InChI=1S/C22H16F2N2O3/c23-14-5-8-16(24)17(10-14)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+ YMKXYCAJEYQQPL-BETUJISGSA-N 50294804 CHEMBL555120::N-(2,5-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294804&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934264 104136335 CHEMBL555120 ZINC62178755 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509851 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1c(F)cccc1F InChI=1S/C22H16F2N2O3/c23-15-2-1-3-16(24)19(15)25-20(27)11-6-8-14(9-7-11)26-21(28)17-12-4-5-13(10-12)18(17)22(26)29/h1-9,12-13,28-29H,10H2,(H,25,27)/t12-,13+ BDNYGBVLDKGFTC-BETUJISGSA-N 50294805 CHEMBL562252::N-(2,6-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294805&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934265 104136336 CHEMBL562252 ZINC62178759 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509852 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(F)c(F)c1 InChI=1S/C22H16F2N2O3/c23-16-8-5-14(10-17(16)24)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+ CZGPKDCBIRBIOB-BETUJISGSA-N 50294806 CHEMBL564614::N-(3,4-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 3000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294806&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934266 104136337 CHEMBL564614 ZINC62178762 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509853 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Cl)c(Cl)c1 InChI=1S/C22H16Cl2N2O3/c23-16-8-5-14(10-17(16)24)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+ NSKQLFWGMGZVNC-BETUJISGSA-N 50294807 CHEMBL563015::N-(3,4-Dichloro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294807&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934267 104136338 CHEMBL563015 ZINC35023453 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509854 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(Br)c(Br)c1 InChI=1S/C22H16Br2N2O3/c23-16-8-5-14(10-17(16)24)25-20(27)11-3-6-15(7-4-11)26-21(28)18-12-1-2-13(9-12)19(18)22(26)29/h1-8,10,12-13,28-29H,9H2,(H,25,27)/t12-,13+ QNCUHHOXXUTCOY-BETUJISGSA-N 50294808 CHEMBL554302::N-(3,4-Dibromo-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294808&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934268 104136339 CHEMBL554302 ZINC70631563 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509855 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cc(F)cc(F)c1 InChI=1S/C22H16F2N2O3/c23-14-8-15(24)10-16(9-14)25-20(27)11-3-5-17(6-4-11)26-21(28)18-12-1-2-13(7-12)19(18)22(26)29/h1-6,8-10,12-13,28-29H,7H2,(H,25,27)/t12-,13+ PVCQLQVJMVNDAU-BETUJISGSA-N 50294809 CHEMBL561247::N-(3,5-Difluoro-phenyl)-4-((1R,2S,6R,7S)-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294809&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934269 104136340 CHEMBL561247 ZINC62178767 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509856 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccccc1C(F)(F)F InChI=1S/C23H17F3N2O3/c24-23(25,26)16-3-1-2-4-17(16)27-20(29)12-7-9-15(10-8-12)28-21(30)18-13-5-6-14(11-13)19(18)22(28)31/h1-10,13-14,30-31H,11H2,(H,27,29)/t13-,14+ DSDCJFIGYPNJLT-OKILXGFUSA-N 50294810 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(2-trifluoromethyl-phenyl)-benzamide::CHEMBL551044 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294810&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934270 104136341 CHEMBL551044 ZINC62178772 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509857 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C23H17F3N2O3/c24-23(25,26)15-2-1-3-16(11-15)27-20(29)12-6-8-17(9-7-12)28-21(30)18-13-4-5-14(10-13)19(18)22(28)31/h1-9,11,13-14,30-31H,10H2,(H,27,29)/t13-,14+ RGQWKIMNDUMTAX-OKILXGFUSA-N 50294811 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)--(3-trifluoromethyl-phenyl)-benzamide::CHEMBL552387 Proto-oncogene Wnt-3 Homo sapiens 20000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294811&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934271 104136342 CHEMBL552387 ZINC62178774 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509858 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C23H17F3N2O3/c24-23(25,26)15-5-7-16(8-6-15)27-20(29)12-3-9-17(10-4-12)28-21(30)18-13-1-2-14(11-13)19(18)22(28)31/h1-10,13-14,30-31H,11H2,(H,27,29)/t13-,14+ WISNABSCOXWSKJ-OKILXGFUSA-N 50294812 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(4-trifluoromethyl-phenyl)-benzamide::CHEMBL564111 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294812&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934272 104136343 CHEMBL564111 ZINC62178780 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509859 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NCc1ccccc1 InChI=1S/C23H20N2O3/c26-21(24-13-14-4-2-1-3-5-14)15-8-10-18(11-9-15)25-22(27)19-16-6-7-17(12-16)20(19)23(25)28/h1-11,16-17,27-28H,12-13H2,(H,24,26)/t16-,17+ ZLZPWLXKGNEOPF-CALCHBBNSA-N 50294813 CHEMBL560509::N-Benzyl-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 20000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294813&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934273 104136344 CHEMBL560509 ZINC04976721 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509860 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NCc1ccccn1 InChI=1S/C22H19N3O3/c26-20(24-12-16-3-1-2-10-23-16)13-6-8-17(9-7-13)25-21(27)18-14-4-5-15(11-14)19(18)22(25)28/h1-10,14-15,27-28H,11-12H2,(H,24,26)/t14-,15+ BZEORUOQJALSKV-GASCZTMLSA-N 50294814 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-pyridin-2-ylmethyl-benzamide::CHEMBL558689 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294814&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934274 104136345 CHEMBL558689 ZINC52566101 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509861 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NCc1cccnc1 InChI=1S/C22H19N3O3/c26-20(24-12-13-2-1-9-23-11-13)14-5-7-17(8-6-14)25-21(27)18-15-3-4-16(10-15)19(18)22(25)28/h1-9,11,15-16,27-28H,10,12H2,(H,24,26)/t15-,16+ PQTWLESIPPHELH-IYBDPMFKSA-N 50294815 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-pyridin-3-ylmethyl-benzamide::CHEMBL554274 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294815&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934275 104136346 CHEMBL554274 ZINC52565953 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509862 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NCc1ccncc1 InChI=1S/C22H19N3O3/c26-20(24-12-13-7-9-23-10-8-13)14-3-5-17(6-4-14)25-21(27)18-15-1-2-16(11-15)19(18)22(25)28/h1-10,15-16,27-28H,11-12H2,(H,24,26)/t15-,16+ VHQCGWMJTFLRJH-IYBDPMFKSA-N 50294816 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-pyridin-4-ylmethyl-benzamide::CHEMBL551775 Proto-oncogene Wnt-3 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294816&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934276 104136347 CHEMBL551775 ZINC52566064 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509863 CO[C@@H]1CCCC[C@H]1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O InChI=1S/C23H26N2O4/c1-29-18-5-3-2-4-17(18)24-21(26)13-8-10-16(11-9-13)25-22(27)19-14-6-7-15(12-14)20(19)23(25)28/h6-11,14-15,17-18,27-28H,2-5,12H2,1H3,(H,24,26)/t14-,15+,17-,18-/m1/s1 XMNKHFBLUIZPFA-CYGHRXIMSA-N 50294817 CHEMBL549349::trans-4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-(2-methoxy-cyclohexyl)-benzamide Proto-oncogene Wnt-3 Homo sapiens 2000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294817&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934277 104136348 CHEMBL549349 ZINC62178784 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509864 O[C@H]1CCCC[C@@H]1NC(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O InChI=1S/C22H24N2O4/c25-17-4-2-1-3-16(17)23-20(26)12-7-9-15(10-8-12)24-21(27)18-13-5-6-14(11-13)19(18)22(24)28/h5-10,13-14,16-17,25,27-28H,1-4,11H2,(H,23,26)/t13-,14+,16-,17-/m0/s1 VPEGQUHJOCURBA-FSDCSDTHSA-N 50294818 CHEMBL551447::trans-4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-((2-hydroxy-cyclohexyl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294818&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934278 104136349 CHEMBL551447 ZINC62178787 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509865 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)NC1CCCCC1 InChI=1S/C22H24N2O3/c25-20(23-16-4-2-1-3-5-16)13-8-10-17(11-9-13)24-21(26)18-14-6-7-15(12-14)19(18)22(24)27/h6-11,14-16,26-27H,1-5,12H2,(H,23,25)/t14-,15+ WDGUVXTVTKEOJS-GASCZTMLSA-N 50294819 CHEMBL564157::N-Cyclohexyl-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-benzamide Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294819&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934279 104136350 CHEMBL564157 ZINC03900211 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509866 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1Cl)C(=O)Nc1cccc2cccnc12 InChI=1S/C25H18ClN3O3/c26-17-12-16(23(30)28-18-5-1-3-13-4-2-10-27-22(13)18)8-9-19(17)29-24(31)20-14-6-7-15(11-14)21(20)25(29)32/h1-10,12,14-15,31-32H,11H2,(H,28,30)/t14-,15+ HIMUYLREVWAZFN-GASCZTMLSA-N 50294820 3-Chloro-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-quinolin-8-yl-benzamide::CHEMBL562892 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294820&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934280 104136351 CHEMBL562892 ZINC62178798 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509867 Cc1cc(ccc1-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O)C(=O)Nc1cccc2cccnc12 InChI=1S/C26H21N3O3/c1-14-12-18(24(30)28-19-6-2-4-15-5-3-11-27-23(15)19)9-10-20(14)29-25(31)21-16-7-8-17(13-16)22(21)26(29)32/h2-12,16-17,31-32H,13H2,1H3,(H,28,30)/t16-,17+ XQXGLIIGFWWYSL-CALCHBBNSA-N 50294821 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-3-methyl-N-quinolin-8-yl-benzamide::CHEMBL559290 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294821&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934281 104136352 CHEMBL559290 ZINC62178800 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509868 COc1cc(ccc1-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O)C(=O)Nc1cccc2cccnc12 InChI=1S/C26H21N3O4/c1-33-20-13-17(24(30)28-18-6-2-4-14-5-3-11-27-23(14)18)9-10-19(20)29-25(31)21-15-7-8-16(12-15)22(21)26(29)32/h2-11,13,15-16,31-32H,12H2,1H3,(H,28,30)/t15-,16+ QPNRCHGMNOSVTL-IYBDPMFKSA-N 50294822 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-3-methoxy-N-quinolin-8-yl-benzamide::CHEMBL549766 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294822&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934282 104136353 CHEMBL549766 ZINC62178805 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509869 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(C(=O)Nc2cccc3cccnc23)c(Cl)c1 InChI=1S/C25H18ClN3O3/c26-18-12-16(29-24(31)20-14-6-7-15(11-14)21(20)25(29)32)8-9-17(18)23(30)28-19-5-1-3-13-4-2-10-27-22(13)19/h1-10,12,14-15,31-32H,11H2,(H,28,30)/t14-,15+ UZVIHKFROGNVJM-GASCZTMLSA-N 50294823 2-Chloro-4-((1R,2S,6R,7S)-3,5-dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-quinolin-8-yl-benzamide::CHEMBL551853 Proto-oncogene Wnt-3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294823&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934283 104136354 CHEMBL551853 ZINC62178806 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509870 Cc1cc(ccc1C(=O)Nc1cccc2cccnc12)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O InChI=1S/C26H21N3O3/c1-14-12-18(29-25(31)21-16-7-8-17(13-16)22(21)26(29)32)9-10-19(14)24(30)28-20-6-2-4-15-5-3-11-27-23(15)20/h2-12,16-17,31-32H,13H2,1H3,(H,28,30)/t16-,17+ RUFVJNVMIATQOS-CALCHBBNSA-N 50294824 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-2-methyl-N-quinolin-8-yl-benzamide::CHEMBL556476 Proto-oncogene Wnt-3 Homo sapiens 2000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294824&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934284 104136355 CHEMBL556476 ZINC62178811 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509871 COc1cc(ccc1C(=O)Nc1cccc2cccnc12)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O InChI=1S/C26H21N3O4/c1-33-20-13-17(29-25(31)21-15-7-8-16(12-15)22(21)26(29)32)9-10-18(20)24(30)28-19-6-2-4-14-5-3-11-27-23(14)19/h2-11,13,15-16,31-32H,12H2,1H3,(H,28,30)/t15-,16+ DHMQKZTXSMGIKD-IYBDPMFKSA-N 50294825 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-2-methoxy-N-quinolin-8-yl-benzamide::CHEMBL559383 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294825&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934285 104136356 CHEMBL559383 ZINC62178817 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509872 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(NC(=O)Nc2cccc3cccnc23)cc1 InChI=1S/C25H20N4O3/c30-23-20-15-6-7-16(13-15)21(20)24(31)29(23)18-10-8-17(9-11-18)27-25(32)28-19-5-1-3-14-4-2-12-26-22(14)19/h1-12,15-16,30-31H,13H2,(H2,27,28,32)/t15-,16+ JZHNQLJJBYEVBD-IYBDPMFKSA-N 50294826 1-[4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-phenyl]-3-quinolin-8-yl-urea::CHEMBL550499 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294826&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934286 104136357 CHEMBL550499 ZINC62178820 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509873 O=C(Nc1cccc2cccnc12)[C@H]1CC[C@@H](CC1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O InChI=1S/C25H25N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-7,12,15-18,20-21H,8-11,13H2,(H,27,29)/t15-,16-,17+,18-,20-,21+ HWBJWUBGNFSNFM-AQKQGEKGSA-N 50294827 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-cyclohexanecarboxylic acid quinolin-8-ylamide::CHEMBL564783 Proto-oncogene Wnt-3 Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294827&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 45267204 104136358 CHEMBL564783 ZINC43122133 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509874 Cc1ccnc2c(NC(=O)[C@H]3CC[C@@H](CC3)N3C(=O)[C@H]4[C@@H]5C[C@@H](C=C5)[C@H]4C3=O)cccc12 InChI=1S/C26H27N3O3/c1-14-11-12-27-23-19(14)3-2-4-20(23)28-24(30)15-7-9-18(10-8-15)29-25(31)21-16-5-6-17(13-16)22(21)26(29)32/h2-6,11-12,15-18,21-22H,7-10,13H2,1H3,(H,28,30)/t15-,16-,17+,18-,21-,22+ YRGQAVAKRGMMAR-MJNMERRXSA-N 50294828 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-cyclohexanecarboxylic acid(4-methyl-quinolin-8-yl)-amide::CHEMBL564772 Proto-oncogene Wnt-3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294828&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 45268952 104136359 CHEMBL564772 ZINC62178824 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509875 Cc1ccc2cccnc2c1NC(=O)[C@H]1CC[C@@H](CC1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O InChI=1S/C26H27N3O3/c1-14-4-5-15-3-2-12-27-23(15)22(14)28-24(30)16-8-10-19(11-9-16)29-25(31)20-17-6-7-18(13-17)21(20)26(29)32/h2-7,12,16-21H,8-11,13H2,1H3,(H,28,30)/t16-,17-,18+,19-,20-,21+ HPDUWGRLSICIEG-JXUYPSSRSA-N 50294829 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-cyclohexanecarboxylic acid(7-methyl-quinolin-8-yl)-amide::CHEMBL563202 Proto-oncogene Wnt-3 Homo sapiens 1000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294829&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 45269803 104136360 CHEMBL563202 ZINC43009956 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509876 O=C(Nc1cccc2cccnc12)N1CCC(CC1)N1C(=O)[C@H]2[C@@H]3C[C@@H](C=C3)[C@H]2C1=O InChI=1S/C24H24N4O3/c29-22-19-15-6-7-16(13-15)20(19)23(30)28(22)17-8-11-27(12-9-17)24(31)26-18-5-1-3-14-4-2-10-25-21(14)18/h1-7,10,15-17,19-20H,8-9,11-13H2,(H,26,31)/t15-,16+,19-,20+ JTPWPQVFMLREET-NFQUHZNNSA-N 50294830 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-piperidine-1-carboxylic acid quinolin-8-ylamide::CHEMBL562821 Proto-oncogene Wnt-3 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294830&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 45267205 104136361 CHEMBL562821 ZINC43073985 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509877 O=C(Nc1cccc2cccnc12)[C@H]1CC[C@H](CN2C(=O)[C@H]3[C@@H]4C[C@@H](C=C4)[C@H]3C2=O)CC1 InChI=1S/C26H27N3O3/c30-24(28-20-5-1-3-16-4-2-12-27-23(16)20)17-8-6-15(7-9-17)14-29-25(31)21-18-10-11-19(13-18)22(21)26(29)32/h1-5,10-12,15,17-19,21-22H,6-9,13-14H2,(H,28,30)/t15-,17-,18-,19+,21-,22+ UQOJIGPIMOLYHM-XDOCLBHYSA-N 50294831 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid quinolin-8-ylamide::CHEMBL552252 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294831&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 45270631 104136362 CHEMBL552252 ZINC62178827 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509878 Cc1ccnc2c(NC(=O)[C@H]3CC[C@H](CN4C(=O)[C@H]5[C@@H]6C[C@@H](C=C6)[C@H]5C4=O)CC3)cccc12 InChI=1S/C27H29N3O3/c1-15-11-12-28-24-20(15)3-2-4-21(24)29-25(31)17-7-5-16(6-8-17)14-30-26(32)22-18-9-10-19(13-18)23(22)27(30)33/h2-4,9-12,16-19,22-23H,5-8,13-14H2,1H3,(H,29,31)/t16-,17-,18-,19+,22-,23+ YZICWGPLBOREGA-IWMXAKPTSA-N 50294832 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid(4-methyl-quinolin-8-yl)-amide::CHEMBL561913 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294832&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 45268076 104136363 CHEMBL561913 ZINC62178829 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509879 Cc1ccc2cccnc2c1NC(=O)[C@H]1CC[C@H](CN2C(=O)[C@H]3[C@@H]4C[C@@H](C=C4)[C@H]3C2=O)CC1 InChI=1S/C27H29N3O3/c1-15-4-7-17-3-2-12-28-24(17)23(15)29-25(31)18-8-5-16(6-9-18)14-30-26(32)21-19-10-11-20(13-19)22(21)27(30)33/h2-4,7,10-12,16,18-22H,5-6,8-9,13-14H2,1H3,(H,29,31)/t16-,18-,19-,20+,21-,22+ LYRJDPVEZODWRJ-CIKGUOONSA-N 50294833 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid(7-methyl-quinolin-8-yl)-amide::CHEMBL551968 Proto-oncogene Wnt-3 Homo sapiens 10000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294833&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 45272350 104136364 CHEMBL551968 ZINC62178833 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509880 CN(C(=O)c1ccc(cc1)-n1c(O)c2[C@H]3C[C@H](C=C3)c2c1O)c1cccc2cccnc12 InChI=1S/C26H21N3O3/c1-28(20-6-2-4-15-5-3-13-27-23(15)20)24(30)16-9-11-19(12-10-16)29-25(31)21-17-7-8-18(14-17)22(21)26(29)32/h2-13,17-18,31-32H,14H2,1H3/t17-,18+ YYLVWUCOSSEPIV-HDICACEKSA-N 50294834 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-methyl-N-quinolin-8-yl-benzamide::CHEMBL551969 Proto-oncogene Wnt-3 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294834&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934287 104136365 CHEMBL551969 ZINC62178840 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509881 Oc1c2[C@H]3C[C@H](C=C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12 InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,30-31H,13H2,(H,27,29)/t16-,17+ OGYSABKWWQZOIU-CALCHBBNSA-N 50294835 4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-yl)-N-methyl-N-quinolin-8-yl-benzamide::CHEMBL551505::CHEMBL562310::N-(Quinolin-8-yl)-4-(endo-4-aza-3,5-dioxotricyclo[5.2.1.02,6]oct-8-en-4-yl)benzamide, 1 Proto-oncogene Wnt-3 Homo sapiens 5000 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294835&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934288 104136366 62883 CHEMBL551505CHEMBL562310 ZINC00915717 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9 50509882 Oc1c2[C@H]3CC[C@H](C3)c2c(O)n1-c1ccc(cc1)C(=O)Nc1cccc2cccnc12 InChI=1S/C25H21N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-5,8-12,16-17,30-31H,6-7,13H2,(H,27,29)/t16-,17+ YSJJBPXHIJYADQ-CALCHBBNSA-N 50294836 4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-4-yl)-N-methyl-N-quinolin-8-yl-benzamide::CHEMBL1956162::CHEMBL551506 Proto-oncogene Wnt-3 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2009.04.040 10.7270/Q2DZ08BS 19410457 Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C The University of Texas Southwestern Medical Center at Dallas http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004170&target=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294836&enzyme=Proto-oncogene+Wnt-3&column=ki&startPg=0&Increment=50&submit=Search 91934289 104136367 CHEMBL1956162CHEMBL551506 ZINC62178842 1 MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK 6AHY Proto-oncogene Wnt-3 WNT3_HUMAN P56703 Q2M237 Q9H1J9