BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50872126 C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C50H90N18O16/c1-27(48(82)68-23-11-16-36(68)46(80)64-33(15-10-22-58-50(55)56)43(77)63-32(13-5-8-20-52)44(78)65-34(49(83)84)17-18-37(54)72)61-42(76)31(14-6-9-21-57-29(3)71)62-39(74)25-59-38(73)24-60-47(81)40(28(2)70)67-45(79)35(26-69)66-41(75)30(53)12-4-7-19-51/h27-28,30-36,40,69-70H,4-26,51-53H2,1-3H3,(H2,54,72)(H,57,71)(H,59,73)(H,60,81)(H,61,76)(H,62,74)(H,63,77)(H,64,80)(H,65,78)(H,66,75)(H,67,79)(H,83,84)(H4,55,56,58)/t27-,28+,30-,31-,32-,33-,34-,35-,36-,40-/m0/s1 ORBNZKNLOVVYLT-MIGAEMFTSA-N 50242433 (2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)-6-acetamidohexanamido]propanoyl]pyrrolidin-2-yl]formamido}pentanamido]hexanamido]-4-carbamoylbutanoic acid::CHEMBL507814 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 21000 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242433 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242433&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560096 104099067 CHEMBL507814 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872127 C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(N)=[NH2+])C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C49H90N20O15/c1-26(46(82)69-22-10-15-34(69)44(80)65-31(14-9-21-59-49(56)57)41(77)64-30(12-4-7-19-51)42(78)66-32(47(83)84)16-17-35(53)72)62-40(76)29(13-5-8-20-58-48(54)55)63-37(74)24-60-36(73)23-61-45(81)38(27(2)71)68-43(79)33(25-70)67-39(75)28(52)11-3-6-18-50/h26-34,38,70-71H,3-25,50-52H2,1-2H3,(H2,53,72)(H,60,73)(H,61,81)(H,62,76)(H,63,74)(H,64,77)(H,65,80)(H,66,78)(H,67,75)(H,68,79)(H,83,84)(H4,54,55,58)(H4,56,57,59)/p+1/t26-,27+,28-,29-,30-,31-,32-,33-,34-,38-/m0/s1 ZDXLROPVSNZYLP-SJRGWJBDSA-O 50242443 CID44560107::[amino({[(5S)-5-{[(2S)-1-[(2S)-2-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-3-carbamoyl-1-carboxypropyl]carbamoyl}pentyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}pyrrolidin-1-yl]-1-oxopropan-2-yl]carbamoyl}-5-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)pentyl]amino})methylidene]azanium::butyryl-lysine peptide NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 3300 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242443&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560107 104099077 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872128 C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(=O)C(F)(F)F)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C50H87F3N18O16/c1-26(46(84)71-22-10-15-34(71)44(82)67-31(14-9-21-61-49(58)59)41(79)66-30(12-4-7-19-55)42(80)68-32(47(85)86)16-17-35(57)74)64-40(78)29(13-5-8-20-60-48(87)50(51,52)53)65-37(76)24-62-36(75)23-63-45(83)38(27(2)73)70-43(81)33(25-72)69-39(77)28(56)11-3-6-18-54/h26-34,38,72-73H,3-25,54-56H2,1-2H3,(H2,57,74)(H,60,87)(H,62,75)(H,63,83)(H,64,78)(H,65,76)(H,66,79)(H,67,82)(H,68,80)(H,69,77)(H,70,81)(H,85,86)(H4,58,59,61)/t26-,27+,28-,29-,30-,31-,32-,33-,34-,38-/m0/s1 HKFWSTJYCMBYDH-SJRGWJBDSA-N 50242442 (2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)-6-(2,2,2-trifluoroacetamido)hexanamido]propanoyl]pyrrolidin-2-yl]formamido}pentanamido]hexanamido]-4-carbamoylbutanoic acid::CHEMBL500768 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 3300 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242442&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560106 104099076 CHEMBL500768 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872129 CCCC(=O)NCCCC[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C52H94N18O16/c1-4-13-39(74)59-23-10-7-16-32(64-41(76)27-61-40(75)26-62-49(83)42(30(3)72)69-47(81)36(28-71)68-43(77)31(55)14-5-8-21-53)44(78)63-29(2)50(84)70-25-12-18-37(70)48(82)66-34(17-11-24-60-52(57)58)45(79)65-33(15-6-9-22-54)46(80)67-35(51(85)86)19-20-38(56)73/h29-37,42,71-72H,4-28,53-55H2,1-3H3,(H2,56,73)(H,59,74)(H,61,75)(H,62,83)(H,63,78)(H,64,76)(H,65,79)(H,66,82)(H,67,80)(H,68,77)(H,69,81)(H,85,86)(H4,57,58,60)/t29-,30+,31-,32-,33-,34-,35-,36-,37-,42-/m0/s1 XMUUKOBHSRGLBS-SYWLZQPCSA-N 50242441 (2S)-2-[(2S)-6-amino-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-6-butanamido-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)hexanamido]propanoyl]pyrrolidin-2-yl]formamido}-5-carbamimidamidopentanamido]hexanamido]-4-carbamoylbutanoic acid::CHEMBL506659 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 16000 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242441&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560105 104099075 CHEMBL506659 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872130 C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(=O)CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C50H90N18O17/c1-27(48(83)68-22-10-15-35(68)46(81)64-32(14-9-21-58-50(55)56)43(78)63-31(12-4-7-19-52)44(79)65-33(49(84)85)16-17-36(54)72)61-42(77)30(13-5-8-20-57-39(75)26-70)62-38(74)24-59-37(73)23-60-47(82)40(28(2)71)67-45(80)34(25-69)66-41(76)29(53)11-3-6-18-51/h27-35,40,69-71H,3-26,51-53H2,1-2H3,(H2,54,72)(H,57,75)(H,59,73)(H,60,82)(H,61,77)(H,62,74)(H,63,78)(H,64,81)(H,65,79)(H,66,76)(H,67,80)(H,84,85)(H4,55,56,58)/t27-,28+,29-,30-,31-,32-,33-,34-,35-,40-/m0/s1 RUEPFGZJCJDIJR-GMQCWQFGSA-N 50242440 (2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)-6-(2-hydroxyacetamido)hexanamido]propanoyl]pyrrolidin-2-yl]formamido}pentanamido]hexanamido]-4-carbamoylbutanoic acid::CHEMBL446124 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 3300 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242440&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560104 104099074 CHEMBL446124 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872131 C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(C)=[NH2+])C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C50H91N19O15/c1-27(48(82)69-23-11-16-36(69)46(80)65-33(15-10-22-59-50(56)57)43(77)64-32(13-5-8-20-52)44(78)66-34(49(83)84)17-18-37(55)72)62-42(76)31(14-6-9-21-58-29(3)53)63-39(74)25-60-38(73)24-61-47(81)40(28(2)71)68-45(79)35(26-70)67-41(75)30(54)12-4-7-19-51/h27-28,30-36,40,70-71H,4-26,51-52,54H2,1-3H3,(H2,53,58)(H2,55,72)(H,60,73)(H,61,81)(H,62,76)(H,63,74)(H,64,77)(H,65,80)(H,66,78)(H,67,75)(H,68,79)(H,83,84)(H4,56,57,59)/p+1/t27-,28+,30-,31-,32-,33-,34-,35-,36-,40-/m0/s1 JCQYPCOLVFCIRV-MIGAEMFTSA-O 50242439 (1-{[(5S)-5-{[(2S)-1-[(2S)-2-{[(1S)-1-{[(1S)-5-amino-1-{[(1S)-3-carbamoyl-1-carboxypropyl]carbamoyl}pentyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}pyrrolidin-1-yl]-1-oxopropan-2-yl]carbamoyl}-5-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)pentyl]amino}ethylidene)azanium::CID44560102::acetyl-lysine peptide NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 3300 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242439 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242439&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560102 104099073 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872132 C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(=O)C(F)F)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C50H88F2N18O16/c1-26(48(84)70-22-10-15-34(70)45(81)66-31(14-9-21-60-50(57)58)42(78)65-30(12-4-7-19-54)43(79)67-32(49(85)86)16-17-35(56)73)63-41(77)29(13-5-8-20-59-47(83)39(51)52)64-37(75)24-61-36(74)23-62-46(82)38(27(2)72)69-44(80)33(25-71)68-40(76)28(55)11-3-6-18-53/h26-34,38-39,71-72H,3-25,53-55H2,1-2H3,(H2,56,73)(H,59,83)(H,61,74)(H,62,82)(H,63,77)(H,64,75)(H,65,78)(H,66,81)(H,67,79)(H,68,76)(H,69,80)(H,85,86)(H4,57,58,60)/t26-,27+,28-,29-,30-,31-,32-,33-,34-,38-/m0/s1 KVYNTSGPUCGJAF-SJRGWJBDSA-N 50242438 (2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)-6-(2,2-difluoroacetamido)hexanamido]propanoyl]pyrrolidin-2-yl]formamido}pentanamido]hexanamido]-4-carbamoylbutanoic acid::CHEMBL525769 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 3300 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242438 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242438&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560101 104099072 CHEMBL525769 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872133 CCC(=O)NCCCC[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C51H92N18O16/c1-4-38(73)58-22-10-7-15-31(63-40(75)26-60-39(74)25-61-48(82)41(29(3)71)68-46(80)35(27-70)67-42(76)30(54)13-5-8-20-52)43(77)62-28(2)49(83)69-24-12-17-36(69)47(81)65-33(16-11-23-59-51(56)57)44(78)64-32(14-6-9-21-53)45(79)66-34(50(84)85)18-19-37(55)72/h28-36,41,70-71H,4-27,52-54H2,1-3H3,(H2,55,72)(H,58,73)(H,60,74)(H,61,82)(H,62,77)(H,63,75)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,80)(H,84,85)(H4,56,57,59)/t28-,29+,30-,31-,32-,33-,34-,35-,36-,41-/m0/s1 YWCILALRNADNSI-XNZBMPBESA-N 50242437 (2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)-6-propanamidohexanamido]propanoyl]pyrrolidin-2-yl]formamido}pentanamido]hexanamido]-4-carbamoylbutanoic acid::CHEMBL450495 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 8600 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242437&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560100 104099071 CHEMBL450495 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872134 C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(C)=S)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C50H90N18O15S/c1-27(48(81)68-23-11-16-36(68)46(79)64-33(15-10-22-58-50(55)56)43(76)63-32(13-5-8-20-52)44(77)65-34(49(82)83)17-18-37(54)71)61-42(75)31(14-6-9-21-57-29(3)84)62-39(73)25-59-38(72)24-60-47(80)40(28(2)70)67-45(78)35(26-69)66-41(74)30(53)12-4-7-19-51/h27-28,30-36,40,69-70H,4-26,51-53H2,1-3H3,(H2,54,71)(H,57,84)(H,59,72)(H,60,80)(H,61,75)(H,62,73)(H,63,76)(H,64,79)(H,65,77)(H,66,74)(H,67,78)(H,82,83)(H4,55,56,58)/t27-,28+,30-,31-,32-,33-,34-,35-,36-,40-/m0/s1 IYCYTGOJRVVGGL-MIGAEMFTSA-N 50242436 (2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)-6-ethanethioamidohexanamido]propanoyl]pyrrolidin-2-yl]formamido}pentanamido]hexanamido]-4-carbamoylbutanoic acid::CHEMBL501380 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 3300 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242436&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560099 104099070 CHEMBL501380 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872135 C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(N)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C49H89N19O16/c1-26(46(81)68-22-10-15-34(68)44(79)64-31(14-9-21-57-48(54)55)41(76)63-30(12-4-7-19-51)42(77)65-32(47(82)83)16-17-35(53)71)61-40(75)29(13-5-8-20-58-49(56)84)62-37(73)24-59-36(72)23-60-45(80)38(27(2)70)67-43(78)33(25-69)66-39(74)28(52)11-3-6-18-50/h26-34,38,69-70H,3-25,50-52H2,1-2H3,(H2,53,71)(H,59,72)(H,60,80)(H,61,75)(H,62,73)(H,63,76)(H,64,79)(H,65,77)(H,66,74)(H,67,78)(H,82,83)(H4,54,55,57)(H3,56,58,84)/t26-,27+,28-,29-,30-,31-,32-,33-,34-,38-/m0/s1 OWMOQCIUHHKZNC-SJRGWJBDSA-N 50242435 (2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2S)-6-(carbamoylamino)-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)hexanamido]propanoyl]pyrrolidin-2-yl]formamido}pentanamido]hexanamido]-4-carbamoylbutanoic acid::CHEMBL500219 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 3300 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242435 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242435&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560098 104099069 CHEMBL500219 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50872136 C[C@@H](O)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCNC(=O)CF)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(O)=O InChI=1S/C50H89FN18O16/c1-27(48(83)69-22-10-15-35(69)46(81)65-32(14-9-21-59-50(56)57)43(78)64-31(12-4-7-19-53)44(79)66-33(49(84)85)16-17-36(55)72)62-42(77)30(13-5-8-20-58-37(73)23-51)63-39(75)25-60-38(74)24-61-47(82)40(28(2)71)68-45(80)34(26-70)67-41(76)29(54)11-3-6-18-52/h27-35,40,70-71H,3-26,52-54H2,1-2H3,(H2,55,72)(H,58,73)(H,60,74)(H,61,82)(H,62,77)(H,63,75)(H,64,78)(H,65,81)(H,66,79)(H,67,76)(H,68,80)(H,84,85)(H4,56,57,59)/t27-,28+,29-,30-,31-,32-,33-,34-,35-,40-/m0/s1 GLNUBBYUZMKLLF-GMQCWQFGSA-N 50242434 (2S)-2-[(2S)-6-amino-2-[(2S)-5-carbamimidamido-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{2-[(2S,3R)-2-[(2S)-2-[(2S)-2,6-diaminohexanamido]-3-hydroxypropanamido]-3-hydroxybutanamido]acetamido}acetamido)-6-(2-fluoroacetamido)hexanamido]propanoyl]pyrrolidin-2-yl]formamido}pentanamido]hexanamido]-4-carbamoylbutanoic acid::CHEMBL525757 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 3300 ChEMBL 10.1074/jbc.M707878200 10.7270/Q2H132W7 17951578 Smith, BC; Denu, JM University of Wisconsin-Madison http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242434 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242434&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 44560097 104099068 CHEMBL525757 C02716 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906928 COCC#CC1N(Cc2ccc(OC)cc2)CCc2cc(OC)c(O)cc12 InChI=1S/C22H25NO4/c1-25-12-4-5-20-19-14-21(24)22(27-3)13-17(19)10-11-23(20)15-16-6-8-18(26-2)9-7-16/h6-9,13-14,20,24H,10-12,15H2,1-3H3 WVSCEUNJMQFTRQ-UHFFFAOYSA-N 50304352 6-methoxy-2-(4-methoxy-benzyl)-1-(3-methoxy-prop-1-ynyl)-1,2,3,4,6,7-hexahydro-isoquinolin-7-ol::CHEMBL611614 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 260000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304352&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 23749472 104158713 CHEMBL611614 ZINC45393883 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906930 Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80) FIAFUQMPZJWCLV-UHFFFAOYSA-N 50336799 5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino)]tris[1,3-benzenesulfonate analogue::8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bisnaphthalene-1,3,5-trisulphonic acid::8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID::8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid(suramin)::8-[(4-methyl-3-{[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzene]amido}benzene)amido]naphthalene-1,3,5-trisulfonic acid::CHEMBL265502::Germanin::Suramin hexasodium::US8835659, Suramin::Urea derivative::suramin NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 240000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50336799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50336799&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search SVR 2H9T,7YET,4YV5,4X3U,3BJW,7AH8,6Z7B,3PP7,1Y4L,3GAN,6CE2,4J4V,2NYR,3BF6,3UR0 5361 125086901 45906 CHEMBL265502 DB04786 1728 C07974 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906931 COCC#CC1N(C)CCc2cc(OC)c(O)cc12 InChI=1S/C15H19NO3/c1-16-7-6-11-9-15(19-3)14(17)10-12(11)13(16)5-4-8-18-2/h9-10,13,17H,6-8H2,1-3H3 BURMEHSWUGTTOX-UHFFFAOYSA-N 50304351 6-methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol::CHEMBL592963 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 130000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304351&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 24168039 104158712 CHEMBL592963 ZINC45347199 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906934 CC(NC(=O)c1ccccc1\N=C\c1c(O)ccc2ccccc12)c1ccccc1 InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+ UXJFDYIHRJGPFS-WPWMEQJKSA-N 50156760 (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide::2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide::2-{[(1-(2-hydroxy-naphthalen-1-yl)meth-(E)-ylidene]amino}-N-(1-phenylethyl)-benzamide::2-{[1-(2-hydroxynaphthalen-1-yl)meth-(E)-ylene]amino}-N-(1-phenylethyl)benzamide::CHEMBL380797::Sirtinol NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 48000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50156760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50156760&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 5717148 104043862 73158 CHEMBL380797 ZINC01226846 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906938 NC(=O)c1cccnc1 InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9) DFPAKSUCGFBDDF-UHFFFAOYSA-N 27507 3-Pyridinecarboxamide::CHEMBL1140::NAM::niacinamide::nicotinamide::pyridine-3-carboxamide NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 91000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27507&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search NCA 5N3H,5NY7,5VW4,5VW5,5VW9,5Z3J,2A15,3UPW,6XV6,3ROD,3ROZ,3ROP,3I9J,2R9J,1ISM,6L71,4A3U,5CF9,2Z77,8AXC,2OD9,8DSC,8DSE,8DSD,8DSI,3U9H,3ZJQ,4RMJ,2QHF,2E5D,2ZB7,3O94,1YC5,5RUC,6TX6,6YGF,6IN7,5J6H,1DMA,2C8A,3DZG,3NN0,5V4V,7OMZ,1YC2,5M10,4HYF,2R6V,2QQG,2H4J,5ROR,7SKK,5WQP,7Z7H,4AE1,5YSI,2OTV,2HJH,1ISI,7WR3,1R15,4YP2,6Z5O,7XN6,7XN5 936 57299216 17154 CHEMBL1140 DB02701 C00153 ZINC00005878 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906939 Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCSC(N)=N)c3ccccc23)c2ccccc12 InChI=1S/C25H23N5O2S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32) DSXXEELGXBCYNQ-UHFFFAOYSA-N 3175 3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione Methanesulfonate::BIM-9::Bisindolylmaleimide 11b::Bisindolylmaleimide IX::CHEMBL6291::ROCHE screening, 57::Ro 31-8220::Ro31-8220::[(3-{3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl)sulfanyl]methanimidamide NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 20000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=3175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=3175&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search DRN 2V7O,4OTH 5083 8032918 38912 CHEMBL6291 5259 ZINC03797930 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906940 OC(=O)CCN1Cc2ccccc2C1=O InChI=1S/C11H11NO3/c13-10(14)5-6-12-7-8-3-1-2-4-9(8)11(12)15/h1-4H,5-7H2,(H,13,14) QMNYVASLMSOSFP-UHFFFAOYSA-N 50304354 3-(1-Oxo-1,3-dihydro-isoindol-2-yl)-propionic acid::3-(1-oxoisoindolin-2-yl)propanoic acid::CHEMBL82949::cid_648461 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 19900 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304354&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 648461 104158715 CHEMBL82949 ZINC00487464 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906941 OC(=O)CCN1Cc2ccccc2C1=O InChI=1S/C11H11NO3/c13-10(14)5-6-12-7-8-3-1-2-4-9(8)11(12)15/h1-4H,5-7H2,(H,13,14) QMNYVASLMSOSFP-UHFFFAOYSA-N 50304354 3-(1-Oxo-1,3-dihydro-isoindol-2-yl)-propionic acid::3-(1-oxoisoindolin-2-yl)propanoic acid::CHEMBL82949::cid_648461 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 19900 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304354&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 648461 104158715 CHEMBL82949 ZINC00487464 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906942 Cc1ccc2[nH]c3C(CCCCc3c2c1)C(N)=O InChI=1S/C15H18N2O/c1-9-6-7-13-12(8-9)10-4-2-3-5-11(15(16)18)14(10)17-13/h6-8,11,17H,2-5H2,1H3,(H2,16,18) BEGPLEUQYHEHLN-UHFFFAOYSA-N 50304356 2-methyl-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide::CHEMBL611953 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 14500 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304356&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 46226668 104158717 CHEMBL611953 ZINC05418039 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906943 Cc1cc(Cl)c(O)c(Cc2c(O)c(Cl)cc(Cl)c2Cl)c1Cl InChI=1S/C14H9Cl5O2/c1-5-2-9(16)13(20)6(11(5)18)3-7-12(19)8(15)4-10(17)14(7)21/h2,4,20-21H,3H2,1H3 VNYAKMBEQSGVBU-UHFFFAOYSA-N 50304355 3,4,6-trichloro-2-(2,5-dichloro-6-hydroxy-3-methylbenzyl)phenol::CHEMBL594863 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 12500 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304355&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 46226675 104158716 CHEMBL594863 ZINC45350024 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906944 CCc1ccc(OCCCC(O)Oc2ccc3c(c2)oc(=O)c2ccccc32)cc1 InChI=1S/C25H24O5/c1-2-17-9-11-18(12-10-17)28-15-5-8-24(26)29-19-13-14-21-20-6-3-4-7-22(20)25(27)30-23(21)16-19/h3-4,6-7,9-14,16,24,26H,2,5,8,15H2,1H3 ZRVNMEZPZXJOIW-UHFFFAOYSA-N 50304357 4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]chromen-3-yl ester::CHEMBL595128 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 6500 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304357&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 46226669 104158718 CHEMBL595128 C01707 ZINC45354260 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906946 NC(=O)C1CCCCc2c1[nH]c1ccc(Cl)cc21 InChI=1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18) ABIVOOWWGYJNLV-UHFFFAOYSA-N 50178766 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide::2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxylic acid amide::CHEMBL446446 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 1300 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50178766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50178766&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 4I5 4I5I,5D7Q 3612016 104064039 CHEMBL446446 ZINC00499304 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906950 CN(C)CCCCC(=O)Nc1ccc(NC(=S)NC(=O)c2ccc(cc2)C(C)(C)C)cc1 InChI=1S/C25H34N4O2S/c1-25(2,3)19-11-9-18(10-12-19)23(31)28-24(32)27-21-15-13-20(14-16-21)26-22(30)8-6-7-17-29(4)5/h9-16H,6-8,17H2,1-5H3,(H,26,30)(H2,27,28,31,32)/p+1 BVJSXSQRIUSRCO-UHFFFAOYSA-O 99917 4-tert-butyl-N-(4-(5-(dimethylamino)pentanamido)phenylcarbamothioyl)benzamide::US8501991, Tenovin 6 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae >100000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=99917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=99917&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search F1W 6GK0 24772043 164041161 ZINC96169930 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906951 Oc1ccc2ccccc2c1Cc1c([nH]c(=S)[nH]c1=O)-c1ccccc1 InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26) RVNSQVIUFZVNAU-UHFFFAOYSA-N 29040 cambinol NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae >1000000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29040&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 3246390 81054469 ZINC07996283 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906953 O=C1CCc2c(O1)ccc1ccccc21 InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2 ISFPDBUKMJDAJH-UHFFFAOYSA-N 29590 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one::CHEMBL86537::splitomicin NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae >600000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29590&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 5269 81055019 75272 CHEMBL86537 ZINC00027374 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906956 CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1 InChI=1S/C53H93N7O13/c1-30(2)20-18-16-14-13-15-17-19-21-36-28-43(61)54-37(22-23-44(62)63)47(66)55-38(24-31(3)4)48(67)57-40(26-33(7)8)51(70)60-46(35(11)12)52(71)58-41(29-45(64)65)50(69)56-39(25-32(5)6)49(68)59-42(27-34(9)10)53(72)73-36/h30-42,46H,13-29H2,1-12H3,(H,54,61)(H,55,66)(H,56,69)(H,57,67)(H,58,71)(H,59,68)(H,60,70)(H,62,63)(H,64,65)/t36-,37+,38+,39-,40-,41+,42+,46+/m1/s1 NJGWOFRZMQRKHT-WGVNQGGSSA-N 50378583 SURFACTIN NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae >700000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378583&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 443592 160857666 71978 C12043 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906957 CCc1ccc(OCCCC(O)Oc2ccc3c(c2)oc(=O)c2ccccc32)cc1 InChI=1S/C25H24O5/c1-2-17-9-11-18(12-10-17)28-15-5-8-24(26)29-19-13-14-21-20-6-3-4-7-22(20)25(27)30-23(21)16-19/h3-4,6-7,9-14,16,24,26H,2,5,8,15H2,1H3 ZRVNMEZPZXJOIW-UHFFFAOYSA-N 50304357 4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]chromen-3-yl ester::CHEMBL595128 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 1200 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304357&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 46226669 104158718 CHEMBL595128 C01707 ZINC45354260 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906958 CCc1ccc(OCCCC(O)Oc2ccc3c(c2)oc(=O)c2ccccc32)cc1 InChI=1S/C25H24O5/c1-2-17-9-11-18(12-10-17)28-15-5-8-24(26)29-19-13-14-21-20-6-3-4-7-22(20)25(27)30-23(21)16-19/h3-4,6-7,9-14,16,24,26H,2,5,8,15H2,1H3 ZRVNMEZPZXJOIW-UHFFFAOYSA-N 50304357 4-(4-ethylphenoxy)-butyric acid 6-oxo-6H-benzo[c]chromen-3-yl ester::CHEMBL595128 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 6300 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304357&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 46226669 104158718 CHEMBL595128 C01707 ZINC45354260 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906959 OC(=O)CCN1Cc2ccccc2C1=O InChI=1S/C11H11NO3/c13-10(14)5-6-12-7-8-3-1-2-4-9(8)11(12)15/h1-4H,5-7H2,(H,13,14) QMNYVASLMSOSFP-UHFFFAOYSA-N 50304354 3-(1-Oxo-1,3-dihydro-isoindol-2-yl)-propionic acid::3-(1-oxoisoindolin-2-yl)propanoic acid::CHEMBL82949::cid_648461 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 30000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304354&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 648461 104158715 CHEMBL82949 ZINC00487464 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906960 OC(=O)CCN1Cc2ccccc2C1=O InChI=1S/C11H11NO3/c13-10(14)5-6-12-7-8-3-1-2-4-9(8)11(12)15/h1-4H,5-7H2,(H,13,14) QMNYVASLMSOSFP-UHFFFAOYSA-N 50304354 3-(1-Oxo-1,3-dihydro-isoindol-2-yl)-propionic acid::3-(1-oxoisoindolin-2-yl)propanoic acid::CHEMBL82949::cid_648461 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 39000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304354&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 648461 104158715 CHEMBL82949 ZINC00487464 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906961 Cc1cc(Cl)c(O)c(Cc2c(O)c(Cl)cc(Cl)c2Cl)c1Cl InChI=1S/C14H9Cl5O2/c1-5-2-9(16)13(20)6(11(5)18)3-7-12(19)8(15)4-10(17)14(7)21/h2,4,20-21H,3H2,1H3 VNYAKMBEQSGVBU-UHFFFAOYSA-N 50304355 3,4,6-trichloro-2-(2,5-dichloro-6-hydroxy-3-methylbenzyl)phenol::CHEMBL594863 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 2500 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304355&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 46226675 104158716 CHEMBL594863 ZINC45350024 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906962 Cc1cc(Cl)c(O)c(Cc2c(O)c(Cl)cc(Cl)c2Cl)c1Cl InChI=1S/C14H9Cl5O2/c1-5-2-9(16)13(20)6(11(5)18)3-7-12(19)8(15)4-10(17)14(7)21/h2,4,20-21H,3H2,1H3 VNYAKMBEQSGVBU-UHFFFAOYSA-N 50304355 3,4,6-trichloro-2-(2,5-dichloro-6-hydroxy-3-methylbenzyl)phenol::CHEMBL594863 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 2500 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304355&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 46226675 104158716 CHEMBL594863 ZINC45350024 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906963 COCC#CC1N(C)CCc2cc(OC)c(O)cc12 InChI=1S/C15H19NO3/c1-16-7-6-11-9-15(19-3)14(17)10-12(11)13(16)5-4-8-18-2/h9-10,13,17H,6-8H2,1-3H3 BURMEHSWUGTTOX-UHFFFAOYSA-N 50304351 6-methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol::CHEMBL592963 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 43000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304351&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 24168039 104158712 CHEMBL592963 ZINC45347199 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7 50906964 COCC#CC1N(C)CCc2cc(OC)c(O)cc12 InChI=1S/C15H19NO3/c1-16-7-6-11-9-15(19-3)14(17)10-12(11)13(16)5-4-8-18-2/h9-10,13,17H,6-8H2,1-3H3 BURMEHSWUGTTOX-UHFFFAOYSA-N 50304351 6-methoxy-1-(3-methoxy-prop-1-ynyl)-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol::CHEMBL592963 NAD-dependent protein deacetylase HST2 Saccharomyces cerevisiae 42000 ChEMBL 10.1016/j.bmc.2009.07.073 10.7270/Q21V5FWG 19734050 Sanders, BD; Jackson, B; Brent, M; Taylor, AM; Dang, W; Berger, SL; Schreiber, SL; Howitz, K; Marmorstein, R Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50304351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004127&target=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50304351&enzyme=NAD-dependent+protein+deacetylase+HST2&column=ki&startPg=0&Increment=50&submit=Search 24168039 104158712 CHEMBL592963 ZINC45347199 1 MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE 1Q14,1Q17,1Q1A,1SZC,1SZD,2OD7,2OD9,2QQF,2QQG,7F4E,7F51 NAD-dependent protein deacetylase HST2 HST2_YEAST P53686 D6W3Z7