BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50169079 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@H](CC1)c1ccccc1 InChI=1S/C28H34F3N3O3/c1-2-37-25-18-34(23-13-11-20(12-14-23)19-7-4-3-5-8-19)17-24(25)33-26(35)16-32-27(36)21-9-6-10-22(15-21)28(29,30)31/h3-10,15,20,23-25H,2,11-14,16-18H2,1H3,(H,32,36)(H,33,35)/t20-,23+,24-,25-/m0/s1 JRKWHQVHPFPWID-PQVVKJAFSA-N 50331722 CHEMBL1290636::N-(2-((3S,4S)-4-ethoxy-1-(cis-4-phenylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 14 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331722&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 50925394 123110837 CHEMBL1290636 ZINC64559528 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50169080 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccccc1 InChI=1S/C28H34F3N3O4/c1-2-38-24-18-34(22-11-13-27(37,14-12-22)20-8-4-3-5-9-20)17-23(24)33-25(35)16-32-26(36)19-7-6-10-21(15-19)28(29,30)31/h3-10,15,22-24,37H,2,11-14,16-18H2,1H3,(H,32,36)(H,33,35)/t22-,23-,24-,27-/m0/s1 KLHQJQIPLYZOOT-TTZMFTMZSA-N 50331726 CHEMBL1289083::N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-phenylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 444 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331726&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 11756884 123110841 CHEMBL1289083 ZINC64549404 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50169081 CCCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@H](CC1)c1ccccc1 InChI=1S/C29H36F3N3O3/c1-2-15-38-26-19-35(24-13-11-21(12-14-24)20-7-4-3-5-8-20)18-25(26)34-27(36)17-33-28(37)22-9-6-10-23(16-22)29(30,31)32/h3-10,16,21,24-26H,2,11-15,17-19H2,1H3,(H,33,37)(H,34,36)/t21-,24+,25-,26-/m0/s1 SQAGKRMXWWHHJT-QUKDMSEQSA-N 50331723 CHEMBL1290637::N-(2-oxo-2-((3S,4S)-1-(cis-4-phenylcyclohexyl)-4-propoxypyrrolidin-3-ylamino)ethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 158 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331723&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 52941377 123110838 CHEMBL1290637 ZINC64559529 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50169084 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccc(C)cc1 InChI=1S/C29H36F3N3O4/c1-3-39-25-18-35(23-11-13-28(38,14-12-23)21-9-7-19(2)8-10-21)17-24(25)34-26(36)16-33-27(37)20-5-4-6-22(15-20)29(30,31)32/h4-10,15,23-25,38H,3,11-14,16-18H2,1-2H3,(H,33,37)(H,34,36)/t23-,24-,25-,28-/m0/s1 JQPQRYDIQFLFAA-MGDCHWCSSA-N 50331727 CHEMBL1289203::N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-p-tolylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 13 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331727&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 10007642 123110842 CHEMBL1289203 ZINC64559888 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50169085 O[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@H](CC1)c1ccccc1 InChI=1S/C26H30F3N3O3/c27-26(28,29)20-8-4-7-19(13-20)25(35)30-14-24(34)31-22-15-32(16-23(22)33)21-11-9-18(10-12-21)17-5-2-1-3-6-17/h1-8,13,18,21-23,33H,9-12,14-16H2,(H,30,35)(H,31,34)/t18-,21+,22-,23-/m0/s1 APTHHLNWTSJLJO-AWDZXFJFSA-N 50331715 CHEMBL1290412::N-(2-((3S,4S)-4-hydroxy-1-(cis-4-phenylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 265 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331715&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 52943756 123110830 CHEMBL1290412 ZINC64550054 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50169086 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccc2OCOc2c1 InChI=1S/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21-,22-,25-,28-/m0/s1 MZEOSVPWMSEFPW-UTWBDPIXSA-N 50331728 CHEMBL1289316::N-(2-((3S,4S)-1-(cis-4-(benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 9.5 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331728&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 10008367 123110843 CHEMBL1289316 777 ZINC64559635 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364589 FC(F)(F)c1cc(CNC(=O)CCCN2CCC3(CC2)OCCc2ccccc32)cc(c1)C(F)(F)F InChI=1S/C26H28F6N2O2/c27-25(28,29)20-14-18(15-21(16-20)26(30,31)32)17-33-23(35)6-3-10-34-11-8-24(9-12-34)22-5-2-1-4-19(22)7-13-36-24/h1-2,4-5,14-16H,3,6-13,17H2,(H,33,35) LLKRKXJNMABFNP-UHFFFAOYSA-N 50097879 CHEMBL3589839 C-C chemokine receptor type 2 Mus musculus 24000 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097879&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181144 318490365 CHEMBL3589839 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364590 CC1Cc2ccccc2C2(CCN(CCCC(=O)NCc3cc(cc(c3)C(F)(F)F)C(F)(F)F)CC2)O1 InChI=1S/C27H30F6N2O2/c1-18-13-20-5-2-3-6-23(20)25(37-18)8-11-35(12-9-25)10-4-7-24(36)34-17-19-14-21(26(28,29)30)16-22(15-19)27(31,32)33/h2-3,5-6,14-16,18H,4,7-13,17H2,1H3,(H,34,36) NARPDGATCGVANV-UHFFFAOYSA-N 50097880 CHEMBL3589840 C-C chemokine receptor type 2 Mus musculus 7900 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097880&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181145 318490366 CHEMBL3589840 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364591 COc1ccc2c(CCOC22CCN(CCCC(=O)NCc3cc(cc(c3)C(F)(F)F)C(F)(F)F)CC2)c1 InChI=1S/C27H30F6N2O3/c1-37-22-4-5-23-19(15-22)6-12-38-25(23)7-10-35(11-8-25)9-2-3-24(36)34-17-18-13-20(26(28,29)30)16-21(14-18)27(31,32)33/h4-5,13-16H,2-3,6-12,17H2,1H3,(H,34,36) WZOIMSRGGIDWKR-UHFFFAOYSA-N 50097881 CHEMBL3589841 C-C chemokine receptor type 2 Mus musculus 18000 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097881&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181146 318490367 CHEMBL3589841 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364592 Fc1cc(CNC(=O)CCCN2CCC3(CC2)OCCc2ccccc32)cc(c1)C(F)(F)F InChI=1S/C25H28F4N2O2/c26-21-15-18(14-20(16-21)25(27,28)29)17-30-23(32)6-3-10-31-11-8-24(9-12-31)22-5-2-1-4-19(22)7-13-33-24/h1-2,4-5,14-16H,3,6-13,17H2,(H,30,32) VCUDHYXMFJECKX-UHFFFAOYSA-N 50097882 CHEMBL3589842 C-C chemokine receptor type 2 Mus musculus >30000 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097882&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181147 318490368 CHEMBL3589842 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364593 CC1Cc2ccccc2C2(CCN(CCCC(=O)NCc3cc(F)cc(c3)C(F)(F)F)CC2)O1 InChI=1S/C26H30F4N2O2/c1-18-13-20-5-2-3-6-23(20)25(34-18)8-11-32(12-9-25)10-4-7-24(33)31-17-19-14-21(26(28,29)30)16-22(27)15-19/h2-3,5-6,14-16,18H,4,7-13,17H2,1H3,(H,31,33) UOTTVBZTWTXCKX-UHFFFAOYSA-N 50097883 CHEMBL3589843 C-C chemokine receptor type 2 Mus musculus >30000 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097883&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181148 318490369 CHEMBL3589843 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364594 COc1ccc2c(CCOC22CCN(CCCC(=O)NCc3cc(F)cc(c3)C(F)(F)F)CC2)c1 InChI=1S/C26H30F4N2O3/c1-34-22-4-5-23-19(15-22)6-12-35-25(23)7-10-32(11-8-25)9-2-3-24(33)31-17-18-13-20(26(28,29)30)16-21(27)14-18/h4-5,13-16H,2-3,6-12,17H2,1H3,(H,31,33) XMQLWLWSABJNMF-UHFFFAOYSA-N 50097885 CHEMBL3589844 C-C chemokine receptor type 2 Mus musculus >30000 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097885&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181149 318490370 CHEMBL3589844 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364595 Fc1ccc(cc1)C(CCN1CCC2(CC1)OCCc1ccccc21)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C32H31F7N2O2/c33-26-7-5-22(6-8-26)27(29(42)40-20-21-17-24(31(34,35)36)19-25(18-21)32(37,38)39)9-13-41-14-11-30(12-15-41)28-4-2-1-3-23(28)10-16-43-30/h1-8,17-19,27H,9-16,20H2,(H,40,42) QHHGOEMDEWUDCB-UHFFFAOYSA-N 50097887 CHEMBL3589845 C-C chemokine receptor type 2 Mus musculus 11200 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097887&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181150 318490371 CHEMBL3589845 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364596 CC1Cc2ccccc2C2(CCN(CCC(C(=O)NCc3cc(cc(c3)C(F)(F)F)C(F)(F)F)c3ccc(F)cc3)CC2)O1 InChI=1S/C33H33F7N2O2/c1-21-16-24-4-2-3-5-29(24)31(44-21)11-14-42(15-12-31)13-10-28(23-6-8-27(34)9-7-23)30(43)41-20-22-17-25(32(35,36)37)19-26(18-22)33(38,39)40/h2-9,17-19,21,28H,10-16,20H2,1H3,(H,41,43) WMUZVSBPEOTIEE-UHFFFAOYSA-N 50097890 CHEMBL3589846 C-C chemokine receptor type 2 Mus musculus 3670 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097890&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181151 318490372 CHEMBL3589846 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364600 C[C@H]1CN(CCC(C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2csc(NC(=O)c3cccnc3)n2)CC[C@]11C=Cc2ccccc12 InChI=1S/C36H33F6N5O2S/c1-22-20-47(14-11-34(22)10-8-24-5-2-3-7-29(24)34)13-9-28(30-21-50-33(45-30)46-31(48)25-6-4-12-43-19-25)32(49)44-18-23-15-26(35(37,38)39)17-27(16-23)36(40,41)42/h2-8,10,12,15-17,19,21-22,28H,9,11,13-14,18,20H2,1H3,(H,44,49)(H,45,46,48)/t22-,28?,34+/m0/s1 QWNVTHCYECOXOH-DHYFXEGDSA-N 50198111 CHEMBL231149::N-{4-[1-({[3,5-bis(trifluoromethyl)phenyl]methyl}carbamoyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]propyl]-1,3-thiazol-2-yl}pyridine-3-carboxamide C-C chemokine receptor type 2 Mus musculus 186 ChEMBL 10.1016/j.bmcl.2006.10.059 10.7270/Q25B0247 17092717 Zhou, C; Guo, L; Parsons, WH; Mills, SG; MacCoss, M; Vicario, PP; Zweerink, H; Cascieri, MA; Springer, MS; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50198111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50198111&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425320 104079183 CHEMBL231149 ZINC28702914 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364606 CC(C(=O)Nc1nc(cs1)C(CCN1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ccccc1 InChI=1S/C39H38F6N4O2S/c1-24-22-49(17-15-37(24)14-12-28-10-6-7-11-32(28)37)16-13-31(33-23-52-36(47-33)48-34(50)25(2)27-8-4-3-5-9-27)35(51)46-21-26-18-29(38(40,41)42)20-30(19-26)39(43,44)45/h3-12,14,18-20,23-25,31H,13,15-17,21-22H2,1-2H3,(H,46,51)(H,47,48,50)/t24-,25?,31?,37+/m0/s1 JWKLHPJIQARGDH-NYQRLVHPSA-N 50198114 CHEMBL231150::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-2-[2-(2-phenylpropanamido)-1,3-thiazol-4-yl]butanamide C-C chemokine receptor type 2 Mus musculus 517 ChEMBL 10.1016/j.bmcl.2006.10.059 10.7270/Q25B0247 17092717 Zhou, C; Guo, L; Parsons, WH; Mills, SG; MacCoss, M; Vicario, PP; Zweerink, H; Cascieri, MA; Springer, MS; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50198114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50198114&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425321 104079186 CHEMBL231150 ZINC95607338 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364609 C[C@H]1CN(CCC(C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2csc(NC(=O)Cc3ccccn3)n2)CC[C@]11C=Cc2ccccc12 InChI=1S/C37H35F6N5O2S/c1-23-21-48(15-12-35(23)11-9-25-6-2-3-8-30(25)35)14-10-29(31-22-51-34(46-31)47-32(49)19-28-7-4-5-13-44-28)33(50)45-20-24-16-26(36(38,39)40)18-27(17-24)37(41,42)43/h2-9,11,13,16-18,22-23,29H,10,12,14-15,19-21H2,1H3,(H,45,50)(H,46,47,49)/t23-,29?,35+/m0/s1 AAMCCXZHVCUGJS-KEHMHDMQSA-N 50198119 CHEMBL231340::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-2-{2-[2-(pyridin-2-yl)acetamido]-1,3-thiazol-4-yl}butanamide C-C chemokine receptor type 2 Mus musculus 79 ChEMBL 10.1016/j.bmcl.2006.10.059 10.7270/Q25B0247 17092717 Zhou, C; Guo, L; Parsons, WH; Mills, SG; MacCoss, M; Vicario, PP; Zweerink, H; Cascieri, MA; Springer, MS; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50198119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50198119&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425319 104079191 CHEMBL231340 ZINC28702910 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364613 C[C@H]1CN(CCC(C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2csc(NC(=O)Cc3ccccc3)n2)CC[C@]11C=Cc2ccccc12 InChI=1S/C38H36F6N4O2S/c1-24-22-48(16-14-36(24)13-11-27-9-5-6-10-31(27)36)15-12-30(32-23-51-35(46-32)47-33(49)19-25-7-3-2-4-8-25)34(50)45-21-26-17-28(37(39,40)41)20-29(18-26)38(42,43)44/h2-11,13,17-18,20,23-24,30H,12,14-16,19,21-22H2,1H3,(H,45,50)(H,46,47,49)/t24-,30?,36+/m0/s1 UXWASFWFYFPAIK-ZDOBVXEZSA-N 50198116 CHEMBL438128::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-2-[2-(2-phenylacetamido)-1,3-thiazol-4-yl]butanamide C-C chemokine receptor type 2 Mus musculus 165 ChEMBL 10.1016/j.bmcl.2006.10.059 10.7270/Q25B0247 17092717 Zhou, C; Guo, L; Parsons, WH; Mills, SG; MacCoss, M; Vicario, PP; Zweerink, H; Cascieri, MA; Springer, MS; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50198116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50198116&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425317 104079188 CHEMBL438128 ZINC28702902 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364627 C[C@H]1CN(CCC(C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2csc(NC(=O)Cc3cccs3)n2)CC[C@]11C=Cc2ccccc12 InChI=1S/C36H34F6N4O2S2/c1-22-20-46(13-11-34(22)10-8-24-5-2-3-7-29(24)34)12-9-28(30-21-50-33(44-30)45-31(47)18-27-6-4-14-49-27)32(48)43-19-23-15-25(35(37,38)39)17-26(16-23)36(40,41)42/h2-8,10,14-17,21-22,28H,9,11-13,18-20H2,1H3,(H,43,48)(H,44,45,47)/t22-,28?,34+/m0/s1 SSLRKYCBEPQPOB-DHYFXEGDSA-N 50198134 CHEMBL395289::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-4-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-2-{2-[2-(thiophen-2-yl)acetamido]-1,3-thiazol-4-yl}butanamide C-C chemokine receptor type 2 Mus musculus 81 ChEMBL 10.1016/j.bmcl.2006.10.059 10.7270/Q25B0247 17092717 Zhou, C; Guo, L; Parsons, WH; Mills, SG; MacCoss, M; Vicario, PP; Zweerink, H; Cascieri, MA; Springer, MS; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50198134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50198134&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425318 104079206 CHEMBL395289 ZINC28702906 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364637 C[C@H]1CN(CCC(C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2csc(NC(=O)C3Cc4ccccc34)n2)CC[C@]11C=Cc2ccccc12 InChI=1S/C39H36F6N4O2S/c1-23-21-49(15-13-37(23)12-10-25-6-3-5-9-32(25)37)14-11-30(33-22-52-36(47-33)48-35(51)31-18-26-7-2-4-8-29(26)31)34(50)46-20-24-16-27(38(40,41)42)19-28(17-24)39(43,44)45/h2-10,12,16-17,19,22-23,30-31H,11,13-15,18,20-21H2,1H3,(H,46,50)(H,47,48,51)/t23-,30?,31?,37+/m0/s1 RLNPOKFCWGHIDM-NRUNXBEZSA-N 50198139 CHEMBL397717::N-{4-[1-({[3,5-bis(trifluoromethyl)phenyl]methyl}carbamoyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]propyl]-1,3-thiazol-2-yl}bicyclo[4.2.0]octa-1(6),2,4-triene-7-carboxamide C-C chemokine receptor type 2 Mus musculus 111 ChEMBL 10.1016/j.bmcl.2006.10.059 10.7270/Q25B0247 17092717 Zhou, C; Guo, L; Parsons, WH; Mills, SG; MacCoss, M; Vicario, PP; Zweerink, H; Cascieri, MA; Springer, MS; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50198139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50198139&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425322 104079211 CHEMBL397717 ZINC95613111 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364640 C[C@H]1CN(CCC(C(=O)NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c2csc(NC(=O)c3ccccc3)n2)CC[C@]11C=Cc2ccccc12 InChI=1S/C37H34F6N4O2S/c1-23-21-47(16-14-35(23)13-11-25-7-5-6-10-30(25)35)15-12-29(31-22-50-34(45-31)46-32(48)26-8-3-2-4-9-26)33(49)44-20-24-17-27(36(38,39)40)19-28(18-24)37(41,42)43/h2-11,13,17-19,22-23,29H,12,14-16,20-21H2,1H3,(H,44,49)(H,45,46,48)/t23-,29?,35+/m0/s1 DJZGCVPXKKXFCC-KEHMHDMQSA-N 50198110 CHEMBL388869::N-{4-[1-({[3,5-bis(trifluoromethyl)phenyl]methyl}carbamoyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]propyl]-1,3-thiazol-2-yl}benzamide C-C chemokine receptor type 2 Mus musculus 952 ChEMBL 10.1016/j.bmcl.2006.10.059 10.7270/Q25B0247 17092717 Zhou, C; Guo, L; Parsons, WH; Mills, SG; MacCoss, M; Vicario, PP; Zweerink, H; Cascieri, MA; Springer, MS; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50198110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50198110&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425316 104079182 CHEMBL388869 ZINC28702898 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364877 COc1ccc2c(CCOC22CCN(CCC(C(=O)NCc3cc(cc(c3)C(F)(F)F)C(F)(F)F)c3ccc(F)cc3)CC2)c1 InChI=1S/C33H33F7N2O3/c1-44-27-6-7-29-23(18-27)9-15-45-31(29)10-13-42(14-11-31)12-8-28(22-2-4-26(34)5-3-22)30(43)41-20-21-16-24(32(35,36)37)19-25(17-21)33(38,39)40/h2-7,16-19,28H,8-15,20H2,1H3,(H,41,43) ADRICAJEEHMWMJ-UHFFFAOYSA-N 50097892 CHEMBL3588870 C-C chemokine receptor type 2 Mus musculus 4160 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097892&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181152 318490373 CHEMBL3588870 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364878 Fc1ccc(cc1)C(CCN1CCC2(CC1)OCCc1ccccc21)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C31H31F5N2O2/c32-25-7-5-22(6-8-25)27(29(39)37-20-21-17-24(31(34,35)36)19-26(33)18-21)9-13-38-14-11-30(12-15-38)28-4-2-1-3-23(28)10-16-40-30/h1-8,17-19,27H,9-16,20H2,(H,37,39) PPJHFLILDOHJMC-UHFFFAOYSA-N 50097893 CHEMBL3589847 C-C chemokine receptor type 2 Mus musculus 3630 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097893&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181153 318490374 CHEMBL3589847 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364879 CC1Cc2ccccc2C2(CCN(CCC(C(=O)NCc3cc(F)cc(c3)C(F)(F)F)c3ccc(F)cc3)CC2)O1 InChI=1S/C32H33F5N2O2/c1-21-16-24-4-2-3-5-29(24)31(41-21)11-14-39(15-12-31)13-10-28(23-6-8-26(33)9-7-23)30(40)38-20-22-17-25(32(35,36)37)19-27(34)18-22/h2-9,17-19,21,28H,10-16,20H2,1H3,(H,38,40) OVVRQDCJYWDMFV-UHFFFAOYSA-N 50097894 CHEMBL3589949 C-C chemokine receptor type 2 Mus musculus 8010 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097894&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181235 318490375 CHEMBL3589949 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364880 COc1ccc2c(CCOC22CCN(CCC(C(=O)NCc3cc(F)cc(c3)C(F)(F)F)c3ccc(F)cc3)CC2)c1 InChI=1S/C32H33F5N2O3/c1-41-27-6-7-29-23(18-27)9-15-42-31(29)10-13-39(14-11-31)12-8-28(22-2-4-25(33)5-3-22)30(40)38-20-21-16-24(32(35,36)37)19-26(34)17-21/h2-7,16-19,28H,8-15,20H2,1H3,(H,38,40) JBPGVGKLUHRKDA-UHFFFAOYSA-N 50098054 CHEMBL3589950 C-C chemokine receptor type 2 Mus musculus 4630 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50098054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50098054&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181236 318490392 CHEMBL3589950 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364881 Oc1ccc2c(CCOC22CCN(CCC(C(=O)NCc3cc(F)cc(c3)C(F)(F)F)c3ccc(F)cc3)CC2)c1 InChI=1S/C31H31F5N2O3/c32-24-3-1-21(2-4-24)27(29(40)37-19-20-15-23(31(34,35)36)18-25(33)16-20)7-11-38-12-9-30(10-13-38)28-6-5-26(39)17-22(28)8-14-41-30/h1-6,15-18,27,39H,7-14,19H2,(H,37,40) PEAXKZJSQUEGLG-UHFFFAOYSA-N 50097900 CHEMBL3589951 C-C chemokine receptor type 2 Mus musculus >30000 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097900&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181237 318490376 CHEMBL3589951 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364882 FC(F)(F)c1cc(CNC(=O)C(CCN2CCC3(CC2)OCCc2ccccc32)C2CC2)cc(c1)C(F)(F)F InChI=1S/C29H32F6N2O2/c30-28(31,32)22-15-19(16-23(17-22)29(33,34)35)18-36-26(38)24(20-5-6-20)7-11-37-12-9-27(10-13-37)25-4-2-1-3-21(25)8-14-39-27/h1-4,15-17,20,24H,5-14,18H2,(H,36,38) YKBMRTZYUFOORD-UHFFFAOYSA-N 50097901 CHEMBL3589952 C-C chemokine receptor type 2 Mus musculus 3300 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097901&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 122181238 318490377 CHEMBL3589952 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50364883 Cc1ccc(cc1)-c1ccc2CCCC(=Cc2c1)C(=O)Nc1ccc(C[N+](C)(C)C2CCOCC2)cc1 InChI=1S/C33H38N2O2/c1-24-7-11-27(12-8-24)28-14-13-26-5-4-6-29(22-30(26)21-28)33(36)34-31-15-9-25(10-16-31)23-35(2,3)32-17-19-37-20-18-32/h7-16,21-22,32H,4-6,17-20,23H2,1-3H3/p+1 XNHZXMPLVSJQFK-UHFFFAOYSA-O 50088301 (E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)tetrahydro-2H-pyran-4-aminium chloride::(TAK779)Dimethyl-(tetrahydro-pyran-4-yl)-{4-[(3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl)-amino]-benzyl}-ammonium; chloride::CHEMBL41275::CHEMBL64322::Dimethyl-(tetrahydro-pyran-4-yl)-{4-[(3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl)-amino]-benzyl}-ammonium; chloride::Dimethyl-(tetrahydro-pyran-4-yl)-{4-[(3-p-tolyl-8,9-dihydro-7H-benzocycloheptene-6-carbonyl)-amino]-benzyl}-ammonium; chloride(TAK-779)::N-(4-(2-p-tolyl-6,7-dihydro-5H-benzo[7]annulene-8-carboxamido)benzyl)-N,N-dimethyl-tetrahydro-2H-pyran-4-aminium chloride::TAK-779 C-C chemokine receptor type 2 Mus musculus 23000 ChEMBL 10.1016/j.bmc.2015.02.019 10.7270/Q23F4RD1 25766632 Strunz, AK; Zweemer, AJ; Weiss, C; Schepmann, D; Junker, A; Heitman, LH; Koch, M; Wünsch, B Westf£lische Wilhelms-Universit£t M£nster http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50088301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50088301&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 183790 103987225 CHEMBL41275CHEMBL64322 ZINC01996578 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385287 CCCCCCC1(CCC(C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C34H42F4N2O/c1-3-4-5-8-13-32(31(41)39-22-25-18-27(34(36,37)38)20-28(35)19-25)14-12-29(21-32)40-17-16-33(24(2)23-40)15-11-26-9-6-7-10-30(26)33/h6-7,9-11,15,18-20,24,29H,3-5,8,12-14,16-17,21-23H2,1-2H3,(H,39,41)/t24-,29?,32?,33+/m0/s1 FONMXWMXXFXJLM-DQGLUBORSA-N 50212123 CHEMBL231143::N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-hexyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide C-C chemokine receptor type 2 Mus musculus 128 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212123&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425650 104088137 CHEMBL231143 ZINC28704084 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385288 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)[C@@H]1CC[C@@](CC2CCC2)(C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C34H38F6N2O/c1-22-21-42(14-13-32(22)12-9-25-7-2-3-8-29(25)32)28-10-11-31(19-28,18-23-5-4-6-23)30(43)41-20-24-15-26(33(35,36)37)17-27(16-24)34(38,39)40/h2-3,7-9,12,15-17,22-23,28H,4-6,10-11,13-14,18-21H2,1H3,(H,41,43)/t22-,28+,31+,32+/m0/s1 NYVVWKWXURQMLL-PSVFVGLHSA-N 50212124 (1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(cyclobutylmethyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL230405 C-C chemokine receptor type 2 Mus musculus 64 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212124&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425637 104088138 CHEMBL230405 ZINC28704021 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385294 CSC[C@@]1(CC[C@H](C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C31H34F6N2OS/c1-20-18-39(12-11-29(20)10-7-22-5-3-4-6-26(22)29)25-8-9-28(16-25,19-41-2)27(40)38-17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h3-7,10,13-15,20,25H,8-9,11-12,16-19H2,1-2H3,(H,38,40)/t20-,25+,28-,29+/m0/s1 QSNHVAXPYDEWER-DAORKYKSSA-N 50212130 (1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-[(methylsulfanyl)methyl]cyclopentane-1-carboxamide::CHEMBL230832 C-C chemokine receptor type 2 Mus musculus 65.5 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212130&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425641 104088144 CHEMBL230832 ZINC28704044 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385299 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)C1CCC(CC2CCC2)(C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C33H38F4N2O/c1-22-21-39(14-13-32(22)12-9-25-7-2-3-8-29(25)32)28-10-11-31(19-28,18-23-5-4-6-23)30(40)38-20-24-15-26(33(35,36)37)17-27(34)16-24/h2-3,7-9,12,15-17,22-23,28H,4-6,10-11,13-14,18-21H2,1H3,(H,38,40)/t22-,28?,31?,32+/m0/s1 CDCVHCPYWPPPPI-CXHPBZKSSA-N 50212129 1-(cyclobutylmethyl)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL231142 C-C chemokine receptor type 2 Mus musculus 559 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212129&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425649 104088143 CHEMBL231142 ZINC28704076 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385301 CCCC1(CCC(C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C31H36F4N2O/c1-3-10-29(28(38)36-19-22-15-24(31(33,34)35)17-25(32)16-22)11-9-26(18-29)37-14-13-30(21(2)20-37)12-8-23-6-4-5-7-27(23)30/h4-8,12,15-17,21,26H,3,9-11,13-14,18-20H2,1-2H3,(H,36,38)/t21-,26?,29?,30+/m0/s1 QVUCDCFWXARAJF-VXJMAOCXSA-N 50212134 CHEMBL231038::N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-propylcyclopentane-1-carboxamide C-C chemokine receptor type 2 Mus musculus 17 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212134&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425646 104088148 CHEMBL231038 ZINC28704066 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385302 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)[C@@H]1CC[C@](C1)(C1CC1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C31H34F4N2O/c1-20-19-37(13-12-29(20)10-8-22-4-2-3-5-27(22)29)26-9-11-30(17-26,23-6-7-23)28(38)36-18-21-14-24(31(33,34)35)16-25(32)15-21/h2-5,8,10,14-16,20,23,26H,6-7,9,11-13,17-19H2,1H3,(H,36,38)/t20-,26+,29+,30-/m0/s1 RXHGFTDZRGDCPK-PATLUPQASA-N 50212127 (1S,3R)-1-cyclopropyl-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL437359 C-C chemokine receptor type 2 Mus musculus 8 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212127&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425652 104088141 CHEMBL437359 ZINC28704094 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385303 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)C1CCC(C1)(C1CC1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C32H34F6N2O/c1-20-19-40(13-12-29(20)10-8-22-4-2-3-5-27(22)29)26-9-11-30(17-26,23-6-7-23)28(41)39-18-21-14-24(31(33,34)35)16-25(15-21)32(36,37)38/h2-5,8,10,14-16,20,23,26H,6-7,9,11-13,17-19H2,1H3,(H,39,41)/t20-,26?,29+,30?/m0/s1 PVVAQUKXSCGSNX-SBWCJTSWSA-N 50212135 CHEMBL266017::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-cyclopropyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide C-C chemokine receptor type 2 Mus musculus 45 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212135&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425640 104088149 CHEMBL266017 ZINC28704042 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385306 COCC1(CCC(C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C30H34F4N2O2/c1-20-18-36(12-11-29(20)10-7-22-5-3-4-6-26(22)29)25-8-9-28(16-25,19-38-2)27(37)35-17-21-13-23(30(32,33)34)15-24(31)14-21/h3-7,10,13-15,20,25H,8-9,11-12,16-19H2,1-2H3,(H,35,37)/t20-,25?,28?,29+/m0/s1 PBLHODZBJXXWDD-FYZPOUGESA-N 50212125 CHEMBL389610::N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-(methoxymethyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide C-C chemokine receptor type 2 Mus musculus 74 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212125&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425651 104088139 CHEMBL389610 ZINC28704090 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385307 CCC[C@@]1(CC[C@H](C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C32H36F6N2O/c1-3-10-29(28(41)39-19-22-15-24(31(33,34)35)17-25(16-22)32(36,37)38)11-9-26(18-29)40-14-13-30(21(2)20-40)12-8-23-6-4-5-7-27(23)30/h4-8,12,15-17,21,26H,3,9-11,13-14,18-20H2,1-2H3,(H,39,41)/t21-,26+,29-,30+/m0/s1 IMMJZWRYKWNOHX-UDJVMPNMSA-N 50212138 (1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-propylcyclopentane-1-carboxamide::CHEMBL387587 C-C chemokine receptor type 2 Mus musculus 44.3 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212138&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425634 104088152 CHEMBL387587 ZINC28704012 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385308 CC(C)C[C@@]1(CC[C@H](C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C33H38F6N2O/c1-21(2)17-30(29(42)40-19-23-14-25(32(34,35)36)16-26(15-23)33(37,38)39)10-9-27(18-30)41-13-12-31(22(3)20-41)11-8-24-6-4-5-7-28(24)31/h4-8,11,14-16,21-22,27H,9-10,12-13,17-20H2,1-3H3,(H,40,42)/t22-,27+,30+,31+/m0/s1 KURSPQDVVXDVFX-DUBVAAOESA-N 50212139 (1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(2-methylpropyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL398000 C-C chemokine receptor type 2 Mus musculus 26 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212139&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425635 104088153 CHEMBL398000 ZINC28704014 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385311 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)[C@@H]1CC[C@@](C)(C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C30H32F6N2O/c1-19-18-38(12-11-28(19)10-7-21-5-3-4-6-25(21)28)24-8-9-27(2,16-24)26(39)37-17-20-13-22(29(31,32)33)15-23(14-20)30(34,35)36/h3-7,10,13-15,19,24H,8-9,11-12,16-18H2,1-2H3,(H,37,39)/t19-,24+,27-,28+/m0/s1 UAKDPJAUOVRMIX-JVRHDVHHSA-N 50212141 (1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-methyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL230617 C-C chemokine receptor type 2 Mus musculus 126 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212141&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425630 104088155 CHEMBL230617 ZINC28703992 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385312 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)[C@@H]1CC[C@@](C)(C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C29H32F4N2O/c1-19-18-35(12-11-28(19)10-7-21-5-3-4-6-25(21)28)24-8-9-27(2,16-24)26(36)34-17-20-13-22(29(31,32)33)15-23(30)14-20/h3-7,10,13-15,19,24H,8-9,11-12,16-18H2,1-2H3,(H,34,36)/t19-,24+,27-,28+/m0/s1 LMCGEWVHFZFMRY-JVRHDVHHSA-N 50212140 (1S,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-methyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL230722 C-C chemokine receptor type 2 Mus musculus 57 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212140&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425643 104088154 CHEMBL230722 ZINC28704048 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385313 CS[C@@]1(CC[C@H](C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C30H32F6N2OS/c1-19-18-38(12-11-27(19)9-7-21-5-3-4-6-25(21)27)24-8-10-28(16-24,40-2)26(39)37-17-20-13-22(29(31,32)33)15-23(14-20)30(34,35)36/h3-7,9,13-15,19,24H,8,10-12,16-18H2,1-2H3,(H,37,39)/t19-,24+,27+,28+/m0/s1 AJPSXOQDVAYDLP-YDWZHMMXSA-N 50212137 (1R,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(methylsulfanyl)cyclopentane-1-carboxamide::CHEMBL388675 C-C chemokine receptor type 2 Mus musculus 351 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212137&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425642 104088151 CHEMBL388675 ZINC28704046 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385317 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)C1CCC(CC2CC2)(C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C33H36F6N2O/c1-21-20-41(13-12-31(21)11-8-24-4-2-3-5-28(24)31)27-9-10-30(18-27,17-22-6-7-22)29(42)40-19-23-14-25(32(34,35)36)16-26(15-23)33(37,38)39/h2-5,8,11,14-16,21-22,27H,6-7,9-10,12-13,17-20H2,1H3,(H,40,42)/t21-,27?,30?,31+/m0/s1 JZQUTVIGHZYROK-SKDYKVSPSA-N 50212142 CHEMBL230078::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(cyclopropylmethyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide C-C chemokine receptor type 2 Mus musculus 63.5 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212142&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425636 104088156 CHEMBL230078 ZINC28704018 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385320 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)C1CCC(CC2CC2)(C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C32H36F4N2O/c1-21-20-38(13-12-31(21)11-8-24-4-2-3-5-28(24)31)27-9-10-30(18-27,17-22-6-7-22)29(39)37-19-23-14-25(32(34,35)36)16-26(33)15-23/h2-5,8,11,14-16,21-22,27H,6-7,9-10,12-13,17-20H2,1H3,(H,37,39)/t21-,27?,30?,31+/m0/s1 NHWLZHAUUGGYKT-SKDYKVSPSA-N 50212131 1-(cyclopropylmethyl)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL436796 C-C chemokine receptor type 2 Mus musculus 15 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212131&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425648 104088145 CHEMBL436796 ZINC28704072 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385321 CCC1(CCC(C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C30H34F4N2O/c1-3-28(27(37)35-18-21-14-23(30(32,33)34)16-24(31)15-21)10-9-25(17-28)36-13-12-29(20(2)19-36)11-8-22-6-4-5-7-26(22)29/h4-8,11,14-16,20,25H,3,9-10,12-13,17-19H2,1-2H3,(H,35,37)/t20-,25?,28?,29+/m0/s1 WZPMKCZRNPIWHY-FYZPOUGESA-N 50212146 1-ethyl-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL230932 C-C chemokine receptor type 2 Mus musculus 3.5 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212146&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425644 104088160 CHEMBL230932 ZINC28704056 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50384309 C[C@H]1CN(CC[C@@]11C=Cc2ccccc12)[C@@H]1CC[C@@](C)(C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C30H32F6N2O/c1-19-18-38(12-11-28(19)10-7-21-5-3-4-6-25(21)28)24-8-9-27(2,16-24)26(39)37-17-20-13-22(29(31,32)33)15-23(14-20)30(34,35)36/h3-7,10,13-15,19,24H,8-9,11-12,16-18H2,1-2H3,(H,37,39)/t19-,24+,27-,28-/m0/s1 UAKDPJAUOVRMIX-FRKLKZNZSA-N 50211499 (1S,3R)-N-[3,5-bis(trifluoromethyl)benzyl]-1-methyl-3-[(1R,3'R)-methyl-1'H-spiro[indene-1,4'-piperidin]-1'-yl]cyclopentanecarboxamide::CHEMBL226066 C-C chemokine receptor type 2 Mus musculus 130 ChEMBL 10.1021/jm070166b 10.7270/Q2WW7HCF 17461566 Yang, L; Butora, G; Jiao, RX; Pasternak, A; Zhou, C; Parsons, WH; Mills, SG; Vicario, PP; Ayala, JM; Cascieri, MA; MacCoss, M Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50211499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50211499&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 11606411 104087668 CHEMBL226066 ZINC28645324 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385324 CS[C@@]1(CC[C@H](C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C29H32F4N2OS/c1-19-18-35(12-11-27(19)9-7-21-5-3-4-6-25(21)27)24-8-10-28(16-24,37-2)26(36)34-17-20-13-22(29(31,32)33)15-23(30)14-20/h3-7,9,13-15,19,24H,8,10-12,16-18H2,1-2H3,(H,34,36)/t19-,24+,27+,28+/m0/s1 MHJVDZLLZRONGX-YDWZHMMXSA-N 50212143 (1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(methylsulfanyl)cyclopentane-1-carboxamide::CHEMBL231247 C-C chemokine receptor type 2 Mus musculus 193 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212143&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425654 104088157 CHEMBL231247 ZINC28704099 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385326 CSC[C@@]1(CC[C@H](C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C30H34F4N2OS/c1-20-18-36(12-11-29(20)10-7-22-5-3-4-6-26(22)29)25-8-9-28(16-25,19-38-2)27(37)35-17-21-13-23(30(32,33)34)15-24(31)14-21/h3-7,10,13-15,20,25H,8-9,11-12,16-19H2,1-2H3,(H,35,37)/t20-,25+,28-,29+/m0/s1 CBXVNXOAKIFVRY-DAORKYKSSA-N 50212122 (1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-[(methylsulfanyl)methyl]cyclopentane-1-carboxamide::CHEMBL231246 C-C chemokine receptor type 2 Mus musculus 17 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212122&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425653 104088136 CHEMBL231246 ZINC28704096 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385327 CCCCCCC1(CCC(C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C35H42F6N2O/c1-3-4-5-8-13-32(31(44)42-22-25-18-27(34(36,37)38)20-28(19-25)35(39,40)41)14-12-29(21-32)43-17-16-33(24(2)23-43)15-11-26-9-6-7-10-30(26)33/h6-7,9-11,15,18-20,24,29H,3-5,8,12-14,16-17,21-23H2,1-2H3,(H,42,44)/t24-,29?,32?,33+/m0/s1 PZTOZWZKJLRLIC-DQGLUBORSA-N 50212133 CHEMBL398001::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-hexyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide C-C chemokine receptor type 2 Mus musculus 279 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212133&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425638 104088147 CHEMBL398001 ZINC28704029 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385332 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)C1CCC(CC2CCC2)(C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C33H38F4N2O/c1-22-21-39(14-13-32(22)12-9-25-7-2-3-8-29(25)32)28-10-11-31(19-28,18-23-5-4-6-23)30(40)38-20-24-15-26(33(35,36)37)17-27(34)16-24/h2-3,7-9,12,15-17,22-23,28H,4-6,10-11,13-14,18-21H2,1H3,(H,38,40)/t22-,28?,31?,32+/m0/s1 CDCVHCPYWPPPPI-CXHPBZKSSA-N 50212129 1-(cyclobutylmethyl)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL231142 C-C chemokine receptor type 2 Mus musculus 147 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212129&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425649 104088143 CHEMBL231142 ZINC28704076 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385333 CCC1(CCC(C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C31H34F6N2O/c1-3-28(27(40)38-18-21-14-23(30(32,33)34)16-24(15-21)31(35,36)37)10-9-25(17-28)39-13-12-29(20(2)19-39)11-8-22-6-4-5-7-26(22)29/h4-8,11,14-16,20,25H,3,9-10,12-13,17-19H2,1-2H3,(H,38,40)/t20-,25?,28?,29+/m0/s1 FEHOZFOZMBPRSW-FYZPOUGESA-N 50212126 CHEMBL388007::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-ethyl-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide C-C chemokine receptor type 2 Mus musculus 17.5 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212126&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425631 104088140 CHEMBL388007 ZINC28704000 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385336 CC(C)[C@@]1(CC[C@H](C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C31H36F4N2O/c1-20(2)30(28(38)36-18-22-14-24(31(33,34)35)16-25(32)15-22)11-9-26(17-30)37-13-12-29(21(3)19-37)10-8-23-6-4-5-7-27(23)29/h4-8,10,14-16,20-21,26H,9,11-13,17-19H2,1-3H3,(H,36,38)/t21-,26+,29+,30-/m0/s1 BWWUOZUJVUFGJV-KAXVLVORSA-N 50212136 (1S,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(propan-2-yl)cyclopentane-1-carboxamide::CHEMBL230933 C-C chemokine receptor type 2 Mus musculus 5 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212136&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425645 104088150 CHEMBL230933 ZINC28704058 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385339 COCC1(CCC(C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C31H34F6N2O2/c1-20-18-39(12-11-29(20)10-7-22-5-3-4-6-26(22)29)25-8-9-28(16-25,19-41-2)27(40)38-17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h3-7,10,13-15,20,25H,8-9,11-12,16-19H2,1-2H3,(H,38,40)/t20-,25?,28?,29+/m0/s1 BZZXSUHOLOFNJP-FYZPOUGESA-N 50212144 CHEMBL230831::N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-1-(methoxymethyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide C-C chemokine receptor type 2 Mus musculus 93 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212144&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425639 104088158 CHEMBL230831 ZINC28704036 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385340 CC(C)[C@@]1(CC[C@H](C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(cc(c1)C(F)(F)F)C(F)(F)F InChI=1S/C32H36F6N2O/c1-20(2)30(28(41)39-18-22-14-24(31(33,34)35)16-25(15-22)32(36,37)38)11-9-26(17-30)40-13-12-29(21(3)19-40)10-8-23-6-4-5-7-27(23)29/h4-8,10,14-16,20-21,26H,9,11-13,17-19H2,1-3H3,(H,39,41)/t21-,26+,29+,30-/m0/s1 FWCVWNSKPMLGCW-KAXVLVORSA-N 50212145 (1S,3R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]-1-(propan-2-yl)cyclopentane-1-carboxamide::CHEMBL230721 C-C chemokine receptor type 2 Mus musculus 15 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212145&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425633 104088159 CHEMBL230721 ZINC28704010 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385342 CC(C)C[C@@]1(CC[C@H](C1)N1CC[C@]2(C=Cc3ccccc23)[C@@H](C)C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C32H38F4N2O/c1-21(2)17-30(29(39)37-19-23-14-25(32(34,35)36)16-26(33)15-23)10-9-27(18-30)38-13-12-31(22(3)20-38)11-8-24-6-4-5-7-28(24)31/h4-8,11,14-16,21-22,27H,9-10,12-13,17-20H2,1-3H3,(H,37,39)/t22-,27+,30+,31+/m0/s1 NGECIXLOAVQTKQ-DUBVAAOESA-N 50212128 (1R,3R)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-1-(2-methylpropyl)-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL231039 C-C chemokine receptor type 2 Mus musculus 7.5 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212128&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425647 104088142 CHEMBL231039 ZINC28704068 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50385345 C[C@H]1CN(CC[C@]11C=Cc2ccccc12)C1CCC(CC2CCC2)(C1)C(=O)NCc1cc(F)cc(c1)C(F)(F)F InChI=1S/C33H38F4N2O/c1-22-21-39(14-13-32(22)12-9-25-7-2-3-8-29(25)32)28-10-11-31(19-28,18-23-5-4-6-23)30(40)38-20-24-15-26(33(35,36)37)17-27(34)16-24/h2-3,7-9,12,15-17,22-23,28H,4-6,10-11,13-14,18-21H2,1H3,(H,38,40)/t22-,28?,31?,32+/m0/s1 CDCVHCPYWPPPPI-CXHPBZKSSA-N 50212129 1-(cyclobutylmethyl)-N-{[3-fluoro-5-(trifluoromethyl)phenyl]methyl}-3-[(1S,5'R)-5'-methylspiro[indene-1,4'-piperidine]-1'-yl]cyclopentane-1-carboxamide::CHEMBL231142 C-C chemokine receptor type 2 Mus musculus 559 ChEMBL 10.1016/j.bmcl.2007.04.053 10.7270/Q23J3CN8 17482462 Butora, G; Jiao, R; Parsons, WH; Vicario, PP; Jin, H; Ayala, JM; Cascieri, MA; Yang, L Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50212129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50212129&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 44425649 104088143 CHEMBL231142 ZINC28704076 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50403296 OC(=O)[C@H](C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)N1CCC(CC1)c1c[nH]c2ccccc12 InChI=1S/C29H30F3N3O3/c30-23-15-18(16-24(31)27(23)32)5-6-26(36)34-11-9-20(10-12-34)28(29(37)38)35-13-7-19(8-14-35)22-17-33-25-4-2-1-3-21(22)25/h1-6,15-17,19-20,28,33H,7-14H2,(H,37,38)/b6-5+/t28-/m0/s1 CJWPNMMSQZADAG-GFPUREGVSA-N 50224496 (S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3,4,5-trifluorophenyl)acryloyl)piperidin-4-yl)acetic acid::CHEMBL237967 C-C chemokine receptor type 2 Mus musculus 2000 ChEMBL 10.1021/jm070902b 10.7270/Q24M948Q 17929797 Xia, M; Hou, C; DeMong, DE; Pollack, SR; Pan, M; Brackley, JA; Jain, N; Gerchak, C; Singer, M; Malaviya, R; Matheis, M; Olini, G; Cavender, D; Wachter, M Johnson & Johnson Pharmaceutical Research and Development LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224496&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 11548199 104096113 CHEMBL237967 ZINC28824808 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50403305 OC(=O)[C@H](C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)N1CCC(CC1)c1c[nH]c2ccccc12 InChI=1S/C29H30F3N3O3/c30-23-15-18(16-24(31)27(23)32)5-6-26(36)34-11-9-20(10-12-34)28(29(37)38)35-13-7-19(8-14-35)22-17-33-25-4-2-1-3-21(22)25/h1-6,15-17,19-20,28,33H,7-14H2,(H,37,38)/b6-5+/t28-/m0/s1 CJWPNMMSQZADAG-GFPUREGVSA-N 50224496 (S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3,4,5-trifluorophenyl)acryloyl)piperidin-4-yl)acetic acid::CHEMBL237967 C-C chemokine receptor type 2 Mus musculus 2000 ChEMBL 10.1021/jm070902b 10.7270/Q24M948Q 17929797 Xia, M; Hou, C; DeMong, DE; Pollack, SR; Pan, M; Brackley, JA; Jain, N; Gerchak, C; Singer, M; Malaviya, R; Matheis, M; Olini, G; Cavender, D; Wachter, M Johnson & Johnson Pharmaceutical Research and Development LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224496&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 11548199 104096113 CHEMBL237967 ZINC28824808 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50403319 OC(=O)[C@H](C1CCN(CC1)C(=O)\C=C\c1cc(F)c(F)c(F)c1)N1CCC(CC1)c1c[nH]c2ccccc12 InChI=1S/C29H30F3N3O3/c30-23-15-18(16-24(31)27(23)32)5-6-26(36)34-11-9-20(10-12-34)28(29(37)38)35-13-7-19(8-14-35)22-17-33-25-4-2-1-3-21(22)25/h1-6,15-17,19-20,28,33H,7-14H2,(H,37,38)/b6-5+/t28-/m0/s1 CJWPNMMSQZADAG-GFPUREGVSA-N 50224496 (S,E)-2-(4-(1H-indol-3-yl)piperidin-1-yl)-2-(1-(3-(3,4,5-trifluorophenyl)acryloyl)piperidin-4-yl)acetic acid::CHEMBL237967 C-C chemokine receptor type 2 Mus musculus 2000 ChEMBL 10.1021/jm070902b 10.7270/Q24M948Q 17929797 Xia, M; Hou, C; DeMong, DE; Pollack, SR; Pan, M; Brackley, JA; Jain, N; Gerchak, C; Singer, M; Malaviya, R; Matheis, M; Olini, G; Cavender, D; Wachter, M Johnson & Johnson Pharmaceutical Research and Development LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224496&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 11548199 104096113 CHEMBL237967 ZINC28824808 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50625077 CO[C@@H]1COCC[C@@H]1N[C@@H]1CC[C@](C1)(C(C)C)C(=O)N1CCN(CC1)c1cc(ccn1)C(F)(F)F InChI=1S/C25H37F3N4O3/c1-17(2)24(7-4-19(15-24)30-20-6-13-35-16-21(20)34-3)23(33)32-11-9-31(10-12-32)22-14-18(5-8-29-22)25(26,27)28/h5,8,14,17,19-21,30H,4,6-7,9-13,15-16H2,1-3H3/t19-,20+,21-,24+/m1/s1 DQWSENNLMPJNRJ-WHLIWEHUSA-N 50337619 ((1S,3R)-1-isopropyl-3-((3S,4S)-3-methoxytetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone::((3S,4S)-N-[(1R,3S)-3-isopropyl-3-({4-[4-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)cyclopentyl]-3-methoxytetrahydro-2H-pyran-4-amine::CHEMBL1683074 C-C chemokine receptor type 2 Mus musculus 2.8 ChEMBL 10.1016/j.bmcl.2011.01.015 10.7270/Q22J6C4C 21295478 Zheng, C; Cao, G; Xia, M; Feng, H; Glenn, J; Anand, R; Zhang, K; Huang, T; Wang, A; Kong, L; Li, M; Galya, L; Hughes, RO; Devraj, R; Morton, PA; Rogier, DJ; Covington, M; Baribaud, F; Shin, N; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B; Xue, CB Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50337619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50337619&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 50992246 125087721 CHEMBL1683074 ZINC35873569 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50610735 O[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@H](CC1)c1ccccc1 InChI=1S/C26H30F3N3O3/c27-26(28,29)20-8-4-7-19(13-20)25(35)30-14-24(34)31-22-15-32(16-23(22)33)21-11-9-18(10-12-21)17-5-2-1-3-6-17/h1-8,13,18,21-23,33H,9-12,14-16H2,(H,30,35)(H,31,34)/t18-,21+,22-,23-/m0/s1 APTHHLNWTSJLJO-AWDZXFJFSA-N 50331715 CHEMBL1290412::N-(2-((3S,4S)-4-hydroxy-1-(cis-4-phenylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 186 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331715&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 52943756 123110830 CHEMBL1290412 ZINC64550054 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50610736 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@H](CC1)c1ccccc1 InChI=1S/C28H34F3N3O3/c1-2-37-25-18-34(23-13-11-20(12-14-23)19-7-4-3-5-8-19)17-24(25)33-26(35)16-32-27(36)21-9-6-10-22(15-21)28(29,30)31/h3-10,15,20,23-25H,2,11-14,16-18H2,1H3,(H,32,36)(H,33,35)/t20-,23+,24-,25-/m0/s1 JRKWHQVHPFPWID-PQVVKJAFSA-N 50331722 CHEMBL1290636::N-(2-((3S,4S)-4-ethoxy-1-(cis-4-phenylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 1.9 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331722&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 50925394 123110837 CHEMBL1290636 ZINC64559528 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50610737 CCCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@H](CC1)c1ccccc1 InChI=1S/C29H36F3N3O3/c1-2-15-38-26-19-35(24-13-11-21(12-14-24)20-7-4-3-5-8-20)18-25(26)34-27(36)17-33-28(37)22-9-6-10-23(16-22)29(30,31)32/h3-10,16,21,24-26H,2,11-15,17-19H2,1H3,(H,33,37)(H,34,36)/t21-,24+,25-,26-/m0/s1 SQAGKRMXWWHHJT-QUKDMSEQSA-N 50331723 CHEMBL1290637::N-(2-oxo-2-((3S,4S)-1-(cis-4-phenylcyclohexyl)-4-propoxypyrrolidin-3-ylamino)ethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 1.9 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331723&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 52941377 123110838 CHEMBL1290637 ZINC64559529 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50610738 CCCCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@H](CC1)c1ccccc1 InChI=1S/C30H38F3N3O3/c1-2-3-16-39-27-20-36(25-14-12-22(13-15-25)21-8-5-4-6-9-21)19-26(27)35-28(37)18-34-29(38)23-10-7-11-24(17-23)30(31,32)33/h4-11,17,22,25-27H,2-3,12-16,18-20H2,1H3,(H,34,38)(H,35,37)/t22-,25+,26-,27-/m0/s1 WSILZVNXWWOLEZ-MKKUMYSQSA-N 50331724 CHEMBL1290754::N-(2-((3S,4S)-4-butoxy-1-(cis-4-phenylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 54 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331724&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 52950180 123110839 CHEMBL1290754 ZINC64559924 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50610739 FC(F)(F)c1cccc(c1)C(=O)NCC(=O)N[C@H]1CN(C[C@@H]1OCc1ccccc1)[C@H]1CC[C@H](CC1)c1ccccc1 InChI=1S/C33H36F3N3O3/c34-33(35,36)27-13-7-12-26(18-27)32(41)37-19-31(40)38-29-20-39(21-30(29)42-22-23-8-3-1-4-9-23)28-16-14-25(15-17-28)24-10-5-2-6-11-24/h1-13,18,25,28-30H,14-17,19-22H2,(H,37,41)(H,38,40)/t25-,28+,29-,30-/m0/s1 NZWUPRQCRRUYHZ-YSGRNVAOSA-N 50331725 CHEMBL1288324::N-(2-((3S,4S)-4-(benzyloxy)-1-(cis-4-phenylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 51 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331725&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 52944966 123110840 CHEMBL1288324 ZINC64550003 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50610740 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccccc1 InChI=1S/C28H34F3N3O4/c1-2-38-24-18-34(22-11-13-27(37,14-12-22)20-8-4-3-5-9-20)17-23(24)33-25(35)16-32-26(36)19-7-6-10-21(15-19)28(29,30)31/h3-10,15,22-24,37H,2,11-14,16-18H2,1H3,(H,32,36)(H,33,35)/t22-,23-,24-,27-/m0/s1 KLHQJQIPLYZOOT-TTZMFTMZSA-N 50331726 CHEMBL1289083::N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-phenylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 10 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331726&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 11756884 123110841 CHEMBL1289083 ZINC64549404 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50610741 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccc(C)cc1 InChI=1S/C29H36F3N3O4/c1-3-39-25-18-35(23-11-13-28(38,14-12-23)21-9-7-19(2)8-10-21)17-24(25)34-26(36)16-33-27(37)20-5-4-6-22(15-20)29(30,31)32/h4-10,15,23-25,38H,3,11-14,16-18H2,1-2H3,(H,33,37)(H,34,36)/t23-,24-,25-,28-/m0/s1 JQPQRYDIQFLFAA-MGDCHWCSSA-N 50331727 CHEMBL1289203::N-(2-((3S,4S)-4-ethoxy-1-(cis-4-hydroxy-4-p-tolylcyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 2.1 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331727&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 10007642 123110842 CHEMBL1289203 ZINC64559888 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50610754 CCO[C@H]1CN(C[C@@H]1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)[C@H]1CC[C@](O)(CC1)c1ccc2OCOc2c1 InChI=1S/C29H34F3N3O6/c1-2-39-25-16-35(21-8-10-28(38,11-9-21)19-6-7-23-24(13-19)41-17-40-23)15-22(25)34-26(36)14-33-27(37)18-4-3-5-20(12-18)29(30,31)32/h3-7,12-13,21-22,25,38H,2,8-11,14-17H2,1H3,(H,33,37)(H,34,36)/t21-,22-,25-,28-/m0/s1 MZEOSVPWMSEFPW-UTWBDPIXSA-N 50331728 CHEMBL1289316::N-(2-((3S,4S)-1-(cis-4-(benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide C-C chemokine receptor type 2 Mus musculus 7.8 ChEMBL 10.1016/j.bmcl.2010.10.020 10.7270/Q2TQ61S9 21036044 Xue, CB; Wang, A; Meloni, D; Zhang, K; Kong, L; Feng, H; Glenn, J; Huang, T; Zhang, Y; Cao, G; Anand, R; Zheng, C; Xia, M; Han, Q; Robinson, DJ; Storace, L; Shao, L; Li, M; Brodmerkel, CM; Covington, M; Scherle, P; Diamond, S; Yeleswaram, S; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B Incyte Corporation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50331728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50331728&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 10008367 123110843 CHEMBL1289316 777 ZINC64559635 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50629286 Cc1nn(C)c2ncc(cc12)C(=O)NC(=O)Nc1ccc(F)c(c1)C(F)(F)F InChI=1S/C17H13F4N5O2/c1-8-11-5-9(7-22-14(11)26(2)25-8)15(27)24-16(28)23-10-3-4-13(18)12(6-10)17(19,20)21/h3-7H,1-2H3,(H2,23,24,27,28) WOMTXGGBILJJNX-UHFFFAOYSA-N 50339635 1-(1,3-Dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea::CHEMBL1688888 C-C chemokine receptor type 2 Mus musculus 1400 ChEMBL 10.1021/jm1012903 10.7270/Q28K79DQ 21341682 Laborde, E; Macsata, RW; Meng, F; Peterson, BT; Robinson, L; Schow, SR; Simon, RJ; Xu, H; Baba, K; Inagaki, H; Ishiwata, Y; Jomori, T; Matsumoto, Y; Miyachi, A; Nakamura, T; Okamoto, M; Handel, TM; Bernard, CC Telik, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339635&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 10272003 125089737 CHEMBL1688888 ZINC00603859 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50629287 CC(C)Oc1cccc(NC(=O)NC(=O)c2cc3c(C)nn(C)c3nc2N(C)CCN(C)C)c1 InChI=1S/C24H33N7O3/c1-15(2)34-18-10-8-9-17(13-18)25-24(33)27-23(32)20-14-19-16(3)28-31(7)22(19)26-21(20)30(6)12-11-29(4)5/h8-10,13-15H,11-12H2,1-7H3,(H2,25,27,32,33) MFORNGKVWCJAME-UHFFFAOYSA-N 50339636 1-(6-((2-(Dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea Hydrochloride::CHEMBL1688889 C-C chemokine receptor type 2 Mus musculus 12000 ChEMBL 10.1021/jm1012903 10.7270/Q28K79DQ 21341682 Laborde, E; Macsata, RW; Meng, F; Peterson, BT; Robinson, L; Schow, SR; Simon, RJ; Xu, H; Baba, K; Inagaki, H; Ishiwata, Y; Jomori, T; Matsumoto, Y; Miyachi, A; Nakamura, T; Okamoto, M; Handel, TM; Bernard, CC Telik, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339636&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 9956238 125089738 CHEMBL1688889 ZINC34049016 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50717214 Cc1ccc(cc1)[C@]1(O)CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F InChI=1S/C27H32F3N3O3/c1-18-5-7-20(8-6-18)26(36)12-9-23(10-13-26)33-14-11-22(17-33)32-24(34)16-31-25(35)19-3-2-4-21(15-19)27(28,29)30/h2-8,15,22-23,36H,9-14,16-17H2,1H3,(H,31,35)(H,32,34)/t22-,23-,26-/m1/s1 YKSPNNYIWLFVCY-JQYIIUTOSA-N 50363942 CHEMBL1951766 C-C chemokine receptor type 2 Mus musculus 18 ChEMBL 10.1021/ml200030q 10.7270/Q2WD4116 24900329 Xue, CB; Feng, H; Cao, G; Huang, T; Glenn, J; Anand, R; Meloni, D; Zhang, K; Kong, L; Wang, A; Zhang, Y; Zheng, C; Xia, M; Chen, L; Tanaka, H; Han, Q; Robinson, DJ; Modi, D; Storace, L; Shao, L; Sharief, V; Li, M; Galya, LG; Covington, M; Scherle, P; Diamond, S; Emm, T; Yeleswaram, S; Contel, N; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363942&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 57402219 136968004 CHEMBL1951766 ZINC73258722 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50717228 Cc1ccc(cc1)[C@]1(O)CC[C@@H](CC1)N1CC[C@H](C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F InChI=1S/C27H32F3N3O3/c1-18-5-7-20(8-6-18)26(36)12-9-23(10-13-26)33-14-11-22(17-33)32-24(34)16-31-25(35)19-3-2-4-21(15-19)27(28,29)30/h2-8,15,22-23,36H,9-14,16-17H2,1H3,(H,31,35)(H,32,34)/t22-,23-,26-/m1/s1 YKSPNNYIWLFVCY-JQYIIUTOSA-N 50363942 CHEMBL1951766 C-C chemokine receptor type 2 Mus musculus 156 ChEMBL 10.1021/ml200030q 10.7270/Q2WD4116 24900329 Xue, CB; Feng, H; Cao, G; Huang, T; Glenn, J; Anand, R; Meloni, D; Zhang, K; Kong, L; Wang, A; Zhang, Y; Zheng, C; Xia, M; Chen, L; Tanaka, H; Han, Q; Robinson, DJ; Modi, D; Storace, L; Shao, L; Sharief, V; Li, M; Galya, LG; Covington, M; Scherle, P; Diamond, S; Emm, T; Yeleswaram, S; Contel, N; Vaddi, K; Newton, R; Hollis, G; Friedman, S; Metcalf, B TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50363942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50363942&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 57402219 136968004 CHEMBL1951766 ZINC73258722 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50929575 CCC[C@H](O)[C@H](CNCc1ccc(C)cc1C)NC(=O)CNC(=O)c1cc(ccc1NC(=O)NCC)C(F)(F)F InChI=1S/C28H38F3N5O4/c1-5-7-24(37)23(15-32-14-19-9-8-17(3)12-18(19)4)35-25(38)16-34-26(39)21-13-20(28(29,30)31)10-11-22(21)36-27(40)33-6-2/h8-13,23-24,32,37H,5-7,14-16H2,1-4H3,(H,34,39)(H,35,38)(H2,33,36,40)/t23-,24-/m0/s1 WMOYUNWNZFLZJG-ZEQRLZLVSA-N 50381177 CHEMBL2018386 C-C chemokine receptor type 2 Mus musculus 4 ChEMBL 10.1016/j.bmcl.2012.03.007 10.7270/Q2PN96MB 22475558 Carter, PH; Brown, GD; King, SR; Voss, ME; Tebben, AJ; Cherney, RJ; Mandlekar, S; Lo, YC; Yang, G; Miller, PB; Scherle, PA; Zhao, Q; Decicco, CP Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50381177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50381177&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 10281316 160860260 CHEMBL2018386 ZINC84617774 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50933355 O[C@]1(CC[C@@H](CC1)N[C@H]1CCN(C1)C(=O)CNC(=O)c1cccc(c1)C(F)(F)F)c1ccc(cn1)-c1ncccn1 InChI=1S/C29H31F3N6O3/c30-29(31,32)21-4-1-3-19(15-21)27(40)36-17-25(39)38-14-9-23(18-38)37-22-7-10-28(41,11-8-22)24-6-5-20(16-35-24)26-33-12-2-13-34-26/h1-6,12-13,15-16,22-23,37,41H,7-11,14,17-18H2,(H,36,40)/t22-,23-,28-/m0/s1 ZNSVOHSYDRPBGI-LXWOLXCRSA-N 50382932 CHEMBL2029422 C-C chemokine receptor type 2 Mus musculus 16 ChEMBL 10.1021/ml200199c 10.7270/Q29024TK 24900280 Xue, CB; Wang, A; Han, Q; Zhang, Y; Cao, G; Feng, H; Huang, T; Zheng, C; Xia, M; Zhang, K; Kong, L; Glenn, J; Anand, R; Meloni, D; Robinson, DJ; Shao, L; Storace, L; Li, M; Hughes, RO; Devraj, R; Morton, PA; Rogier, DJ; Covington, M; Scherle, P; Diamond, S; Emm, T; Yeleswaram, S; Contel, N; Vaddi, K; Newton, R; Hollis, G; Metcalf, B TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382932&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 11192346 160862015 CHEMBL2029422 ZINC72317468 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50933356 O[C@]1(CC[C@@H](CC1)N[C@H]1CCN(C1)C(=O)CNC(=O)c1cccc(c1)C(F)(F)F)c1ccc(cn1)-c1ncccn1 InChI=1S/C29H31F3N6O3/c30-29(31,32)21-4-1-3-19(15-21)27(40)36-17-25(39)38-14-9-23(18-38)37-22-7-10-28(41,11-8-22)24-6-5-20(16-35-24)26-33-12-2-13-34-26/h1-6,12-13,15-16,22-23,37,41H,7-11,14,17-18H2,(H,36,40)/t22-,23-,28-/m0/s1 ZNSVOHSYDRPBGI-LXWOLXCRSA-N 50382932 CHEMBL2029422 C-C chemokine receptor type 2 Mus musculus 17 ChEMBL 10.1021/ml200199c 10.7270/Q29024TK 24900280 Xue, CB; Wang, A; Han, Q; Zhang, Y; Cao, G; Feng, H; Huang, T; Zheng, C; Xia, M; Zhang, K; Kong, L; Glenn, J; Anand, R; Meloni, D; Robinson, DJ; Shao, L; Storace, L; Li, M; Hughes, RO; Devraj, R; Morton, PA; Rogier, DJ; Covington, M; Scherle, P; Diamond, S; Emm, T; Yeleswaram, S; Contel, N; Vaddi, K; Newton, R; Hollis, G; Metcalf, B TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50382932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50382932&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 11192346 160862015 CHEMBL2029422 ZINC72317468 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50939967 CC(C)N1CCN[C@H](C1)C(=O)N1CCN(CC1)C(=O)Nc1ccc(Cl)c(Cl)c1 InChI=1S/C19H27Cl2N5O2/c1-13(2)26-6-5-22-17(12-26)18(27)24-7-9-25(10-8-24)19(28)23-14-3-4-15(20)16(21)11-14/h3-4,11,13,17,22H,5-10,12H2,1-2H3,(H,23,28)/t17-/m1/s1 OOGWCCRYNCAIBK-QGZVFWFLSA-N 50385450 CHEMBL2036782 C-C chemokine receptor type 2 Mus musculus 1200 ChEMBL 10.1016/j.bmcl.2012.04.118 10.7270/Q2PG1SRD 22608963 Cumming, JG; Bower, JF; Waterson, D; Faull, A; Poyser, PJ; Turner, P; McDermott, B; Campbell, AD; Hudson, J; James, M; Winter, J; Wood, C AstraZeneca http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50385450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50385450&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 57656833 160864533 CHEMBL2036782 ZINC84725738 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50979676 Clc1ccc(Cn2ccnn2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1 InChI=1S/C15H11Cl3N4O2S/c16-11-2-1-10(9-22-6-5-19-21-22)15(7-11)20-25(23,24)12-3-4-13(17)14(18)8-12/h1-8,20H,9H2 YGWURLOZYUXZKA-UHFFFAOYSA-N 50401549 CHEMBL2207081 C-C chemokine receptor type 2 Mus musculus >1995.26 ChEMBL 10.1016/j.bmcl.2012.09.020 10.7270/Q21J9BZJ 23079519 Smethurst, CA; Bevan, N; Brooks, C; Emmons, A; Gough, PJ; Mookherjee, C; Moores, K; Peace, S; Philp, J; Piercy, V; Watson, SP; Zippoli, M GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50401549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50401549&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 15985912 163350573 CHEMBL2207081 ZINC34851251 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 50977045 O[C@]1(CC[C@@H](CC1)N1CC(C1)NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)c1cncs1 InChI=1S/C22H25F3N4O3S/c23-22(24,25)15-3-1-2-14(8-15)20(31)27-10-19(30)28-16-11-29(12-16)17-4-6-21(32,7-5-17)18-9-26-13-33-18/h1-3,8-9,13,16-17,32H,4-7,10-12H2,(H,27,31)(H,28,30)/t17-,21- CFKBNYUHQSQBSX-CYWCHRQTSA-N 50400695 CHEMBL2204263 C-C chemokine receptor type 2 Mus musculus 9600 ChEMBL 10.1021/ml300260s 10.7270/Q2JS9RM3 24900425 Zhang, X; Hou, C; Hufnagel, H; Singer, M; Opas, E; McKenney, S; Johnson, D; Sui, Z TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50400695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50400695&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 46208367 163349719 CHEMBL2204263 ZINC95562718 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016457 Cc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)c(Oc2ccccc2C(O)=O)c1 InChI=1S/C20H16ClNO5S/c1-13-6-11-17(22-28(25,26)15-9-7-14(21)8-10-15)19(12-13)27-18-5-3-2-4-16(18)20(23)24/h2-12,22H,1H3,(H,23,24) PQFNRRBAVCCUKA-UHFFFAOYSA-N 50416292 CHEMBL1171207 C-C chemokine receptor type 2 Mus musculus 630.96 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416292&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798326 163365316 CHEMBL1171207 ZINC53296544 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016458 OC(=O)c1ccccc1Oc1c(Cl)cccc1NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C19H13Cl2NO5S/c20-12-8-10-13(11-9-12)28(25,26)22-16-6-3-5-15(21)18(16)27-17-7-2-1-4-14(17)19(23)24/h1-11,22H,(H,23,24) SIQSPIJXICYYSX-UHFFFAOYSA-N 50416293 CHEMBL1171938 C-C chemokine receptor type 2 Mus musculus 501.19 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416293&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798325 163365317 CHEMBL1171938 ZINC53297003 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016459 OC(=O)c1ccccc1Oc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C19H13Cl2NO5S/c20-12-5-8-14(9-6-12)28(25,26)22-16-11-13(21)7-10-18(16)27-17-4-2-1-3-15(17)19(23)24/h1-11,22H,(H,23,24) UJVMKYVBFDLEFW-UHFFFAOYSA-N 50416294 CHEMBL1171760 C-C chemokine receptor type 2 Mus musculus 158.49 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416294&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798323 163365318 CHEMBL1171760 ZINC53243539 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016460 OC(=O)c1ccccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(Cl)cc1)C#N InChI=1S/C20H13ClN2O5S/c21-14-6-8-15(9-7-14)29(26,27)23-17-11-13(12-22)5-10-19(17)28-18-4-2-1-3-16(18)20(24)25/h1-11,23H,(H,24,25) LBRSBMPJWFLCEE-UHFFFAOYSA-N 50416295 CHEMBL1169652 C-C chemokine receptor type 2 Mus musculus 1000 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416295 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416295&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798291 163365319 CHEMBL1169652 ZINC53294018 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016468 OC(=O)c1ccccc1Oc1c(F)cc(cc1NS(=O)(=O)c1ccc(Cl)cc1)C(F)(F)F InChI=1S/C20H12ClF4NO5S/c21-12-5-7-13(8-6-12)32(29,30)26-16-10-11(20(23,24)25)9-15(22)18(16)31-17-4-2-1-3-14(17)19(27)28/h1-10,26H,(H,27,28) AHVWEICLWNKDKM-UHFFFAOYSA-N 50416300 CHEMBL1171006 C-C chemokine receptor type 2 Mus musculus 251.19 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416300&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798265 163365324 CHEMBL1171006 ZINC53230157 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016469 OC(=O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C19H14ClNO5S/c20-13-9-11-14(12-10-13)27(24,25)21-16-6-2-4-8-18(16)26-17-7-3-1-5-15(17)19(22)23/h1-12,21H,(H,22,23) IKYXYVLOGJLJTF-UHFFFAOYSA-N 50416301 CHEMBL1171758 C-C chemokine receptor type 2 Mus musculus 1995.26 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416301&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798264 163365325 CHEMBL1171758 ZINC53298820 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016470 OC(=O)c1ccccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(Cl)cc1)C(F)(F)F InChI=1S/C20H13ClF3NO5S/c21-13-6-8-14(9-7-13)31(28,29)25-16-11-12(20(22,23)24)5-10-18(16)30-17-4-2-1-3-15(17)19(26)27/h1-11,25H,(H,26,27) IWSNTIDXIKYXSU-UHFFFAOYSA-N 50416302 CHEMBL1171586 C-C chemokine receptor type 2 Mus musculus 1584.89 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416302&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 19430534 163365326 CHEMBL1171586 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016526 OC(=O)c1ccccc1Oc1cccc(F)c1NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C19H13ClFNO5S/c20-12-8-10-13(11-9-12)28(25,26)22-18-15(21)5-3-7-17(18)27-16-6-2-1-4-14(16)19(23)24/h1-11,22H,(H,23,24) DCIFJRWUJPIGHB-UHFFFAOYSA-N 50416296 CHEMBL1171208 C-C chemokine receptor type 2 Mus musculus >3162.28 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416296 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416296&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798327 163365320 CHEMBL1171208 ZINC53243541 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016527 Cc1cccc(NS(=O)(=O)c2ccc(Cl)cc2)c1Oc1ccccc1C(O)=O InChI=1S/C20H16ClNO5S/c1-13-5-4-7-17(22-28(25,26)15-11-9-14(21)10-12-15)19(13)27-18-8-3-2-6-16(18)20(23)24/h2-12,22H,1H3,(H,23,24) NGFFIJQHBMXVTF-UHFFFAOYSA-N 50416297 CHEMBL1171761 C-C chemokine receptor type 2 Mus musculus >3162.28 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416297 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416297&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798324 163365321 CHEMBL1171761 ZINC53298825 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016528 OC(=O)c1ccccc1Oc1ccc(F)cc1NS(=O)(=O)c1ccc(Cl)cc1 InChI=1S/C19H13ClFNO5S/c20-12-5-8-14(9-6-12)28(25,26)22-16-11-13(21)7-10-18(16)27-17-4-2-1-3-15(17)19(23)24/h1-11,22H,(H,23,24) LEZFXNWLSJUDTJ-UHFFFAOYSA-N 50416298 CHEMBL1169653 C-C chemokine receptor type 2 Mus musculus 251.19 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416298 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416298&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798292 163365322 CHEMBL1169653 ZINC53243229 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51016532 OC(=O)c1c(F)cccc1Oc1ccc(cc1NS(=O)(=O)c1ccc(Cl)cc1)C(F)(F)F InChI=1S/C20H12ClF4NO5S/c21-12-5-7-13(8-6-12)32(29,30)26-15-10-11(20(23,24)25)4-9-16(15)31-17-3-1-2-14(22)18(17)19(27)28/h1-10,26H,(H,27,28) FHDXWXJVGRMTTN-UHFFFAOYSA-N 50416303 CHEMBL1170391 C-C chemokine receptor type 2 Mus musculus 1000 ChEMBL 10.1016/j.bmcl.2010.04.142 10.7270/Q2B56KZ9 20627722 Peace, S; Philp, J; Brooks, C; Piercy, V; Moores, K; Smethurst, C; Watson, S; Gaines, S; Zippoli, M; Mookherjee, C; Ife, R GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50416303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50416303&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 49798289 163365327 CHEMBL1170391 ZINC53294121 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172 51431512 CC(=O)N[C@@H]1C[C@@H](CC[C@@H]1N1CC[C@H](Nc2ncnc3cc(nn23)C(C)(C)C)C1=O)NC(C)(C)C InChI=1S/C25H40N8O2/c1-15(34)28-18-12-16(30-25(5,6)7)8-9-19(18)32-11-10-17(22(32)35)29-23-27-14-26-21-13-20(24(2,3)4)31-33(21)23/h13-14,16-19,30H,8-12H2,1-7H3,(H,28,34)(H,26,27,29)/t16-,17+,18-,19+/m1/s1 CMVHFGNTABZQJU-HCXYKTFWSA-N 50578294 Bms 813160::Bms-813160 C-C chemokine receptor type 2 Mus musculus 45 ChEMBL 10.1021/acsmedchemlett.1c00373 10.7270/Q2M04981 34795864 Cherney, RJ; Anjanappa, P; Selvakumar, K; Batt, DG; Brown, GD; Rose, AV; Vuppugalla, R; Chen, J; Pang, J; Xu, S; Yarde, M; Tebben, AJ; Paidi, VR; Cvijic, ME; Mathur, A; Barrish, JC; Mandlekar, S; Zhao, Q; Carter, PH Bristol Myers Squibb Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50578294 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003603&target=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50578294&enzyme=C-C+chemokine+receptor+type+2&column=ki&startPg=0&Increment=50&submit=Search 51039119 471054417 1 MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL C-C chemokine receptor type 2 CCR2_MOUSE P51683 Q61172