BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50020440 OC(=O)c1cc(-c2ccc(cc2)-c2ccccc2)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C22H14Cl2N2O2/c23-17-10-11-20(18(24)12-17)26-21(13-19(25-26)22(27)28)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-13H,(H,27,28) XPIHGXBSMIVTBJ-UHFFFAOYSA-N 50129547 5-Biphenyl-4-yl-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL306353 Methionine--tRNA ligase, cytoplasmic Homo sapiens 40900 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129547&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311473 104021130 CHEMBL306353 ZINC13534725 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020482 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(F)cc2)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C22H13Cl2FN2O2/c23-16-7-10-20(18(24)11-16)27-21(12-19(26-27)22(28)29)15-3-1-13(2-4-15)14-5-8-17(25)9-6-14/h1-12H,(H,28,29) CJYADRABSMIPKS-UHFFFAOYSA-N 50129552 1-(2,4-Dichloro-phenyl)-5-(4'-fluoro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL304623 Methionine--tRNA ligase, cytoplasmic Homo sapiens 41300 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129552&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311737 104021135 CHEMBL304623 ZINC13534721 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020492 Clc1ccc(c(Cl)c1)-c1ccc(cc1)-c1cc(nn1-c1ccccn1)-n1cnnn1 InChI=1S/C21H13Cl2N7/c22-16-8-9-17(18(23)11-16)14-4-6-15(7-5-14)19-12-21(29-13-25-27-28-29)26-30(19)20-3-1-2-10-24-20/h1-13H XSQZDTHEDIJOJK-UHFFFAOYSA-N 50129528 2-[5-(2',4'-Dichloro-biphenyl-4-yl)-3-tetrazol-1-yl-pyrazol-1-yl]-pyridine::CHEMBL308349 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1790 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129528&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311501 104021111 CHEMBL308349 ZINC26288967 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020493 Clc1ccc(c(Cl)c1)-c1ccc(cc1)-c1cc(nn1-c1cccnc1)-n1cnnn1 InChI=1S/C21H13Cl2N7/c22-16-7-8-18(19(23)10-16)14-3-5-15(6-4-14)20-11-21(29-13-25-27-28-29)26-30(20)17-2-1-9-24-12-17/h1-13H VIKLLMSXXJAPQB-UHFFFAOYSA-N 50129541 3-[5-(2',4'-Dichloro-biphenyl-4-yl)-3-tetrazol-1-yl-pyrazol-1-yl]-pyridine::CHEMBL72005 Methionine--tRNA ligase, cytoplasmic Homo sapiens 7000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129541&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311500 104021124 CHEMBL72005 ZINC26288961 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020496 Clc1ccc(c(Cl)c1)-c1ccc(cc1)-c1cc(nn1-c1cccnc1)C(=O)NCc1nnn[nH]1 InChI=1S/C23H16Cl2N8O/c24-16-7-8-18(19(25)10-16)14-3-5-15(6-4-14)21-11-20(23(34)27-13-22-28-31-32-29-22)30-33(21)17-2-1-9-26-12-17/h1-12H,13H2,(H,27,34)(H,28,29,31,32) JPMLNAZNRRYWQE-UHFFFAOYSA-N 50129527 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-yl-1H-pyrazole-3-carboxylic acid (1H-tetrazol-5-ylmethyl)-amide::CHEMBL307342 Methionine--tRNA ligase, cytoplasmic Homo sapiens 3700 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129527&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10345487 104021110 CHEMBL307342 ZINC13534774 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020498 CCn1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C18H14Cl2N2O2/c1-2-22-17(10-16(21-22)18(23)24)12-5-3-11(4-6-12)14-8-7-13(19)9-15(14)20/h3-10H,2H2,1H3,(H,23,24) YXLFQADORAOUEZ-UHFFFAOYSA-N 50129532 5-(2',4'-Dichloro-biphenyl-4-yl)-1-ethyl-1H-pyrazole-3-carboxylic acid::CHEMBL69993 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1020 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129532&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311410 104021115 CHEMBL69993 ZINC13534753 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020502 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1cccc(c1)C(O)=O InChI=1S/C23H14Cl2N2O4/c24-16-8-9-18(19(25)11-16)13-4-6-14(7-5-13)21-12-20(23(30)31)26-27(21)17-3-1-2-15(10-17)22(28)29/h1-12H,(H,28,29)(H,30,31) GWPFSCZOMVLNRB-UHFFFAOYSA-N 50129526 1-(3-Carboxy-phenyl)-5-(2',4'-dichloro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL73462 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129526&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311649 104021109 CHEMBL73462 ZINC13534737 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020509 NC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccccn1 InChI=1S/C21H14Cl2N4O/c22-15-8-9-16(17(23)11-15)13-4-6-14(7-5-13)19-12-18(21(24)28)26-27(19)20-3-1-2-10-25-20/h1-12H,(H2,24,28) OYCJBDPYEJFYMO-UHFFFAOYSA-N 50129529 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-2-yl-1H-pyrazole-3-carboxylic acid amide::CHEMBL72460 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129529&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311708 104021112 CHEMBL72460 ZINC13534768 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020511 OC(=O)CNC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1cccnc1 InChI=1S/C23H16Cl2N4O3/c24-16-7-8-18(19(25)10-16)14-3-5-15(6-4-14)21-11-20(23(32)27-13-22(30)31)28-29(21)17-2-1-9-26-12-17/h1-12H,13H2,(H,27,32)(H,30,31) QHOSDKDHULDMOD-UHFFFAOYSA-N 50129551 CHEMBL74224::{[5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-yl-1H-pyrazole-3-carbonyl]-amino}-acetic acid Methionine--tRNA ligase, cytoplasmic Homo sapiens 20000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129551&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311707 104021134 CHEMBL74224 ZINC13534771 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020512 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H13Cl2F3N2O3/c24-15-5-10-18(19(25)11-15)13-1-3-14(4-2-13)21-12-20(22(31)32)29-30(21)16-6-8-17(9-7-16)33-23(26,27)28/h1-12H,(H,31,32) BELUHHKXAXFLAR-UHFFFAOYSA-N 50129530 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL72421 Methionine--tRNA ligase, cytoplasmic Homo sapiens 47400 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129530&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311661 104021113 CHEMBL72421 ZINC26295049 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020517 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccccn1 InChI=1S/C21H13Cl2N3O2/c22-15-8-9-16(17(23)11-15)13-4-6-14(7-5-13)19-12-18(21(27)28)25-26(19)20-3-1-2-10-24-20/h1-12H,(H,27,28) WEHXTYFZRAPTMR-UHFFFAOYSA-N 50129546 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-2-yl-1H-pyrazole-3-carboxylic acid::CHEMBL302471 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1930 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129546&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10250987 104021129 CHEMBL302471 ZINC13534762 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027854 C\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C25H25BrN4O5/c1-14(21-25(34)35-24(29-21)16-6-8-17(26)9-7-16)30-12-2-3-20(30)23(33)28-19(22(27)32)13-15-4-10-18(31)11-5-15/h4-11,19-20,31H,2-3,12-13H2,1H3,(H2,27,32)(H,28,33)/b21-14-/t19-,20-/m0/s1 ACKYJUCEEPBWJV-MSWATVTMSA-N 50143335 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-ethyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56463 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1670 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143335&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299527 104032529 CHEMBL56463 ZINC29555238 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027861 CCC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C27H29BrN4O5/c1-2-4-21(23-27(36)37-26(31-23)17-8-10-18(28)11-9-17)32-14-3-5-22(32)25(35)30-20(24(29)34)15-16-6-12-19(33)13-7-16/h6-13,20,22,33H,2-5,14-15H2,1H3,(H2,29,34)(H,30,35)/b23-21-/t20-,22-/m0/s1 YKFJRHPAYFCCSS-WMKNKADMSA-N 50143339 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL292230 Methionine--tRNA ligase, cytoplasmic Homo sapiens 760 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143339&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299523 104032533 CHEMBL292230 ZINC29553683 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027863 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1\C=C1/N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C23H21BrN4O5/c24-15-5-3-14(4-6-15)22-27-18(23(32)33-22)12-28-10-9-19(28)21(31)26-17(20(25)30)11-13-1-7-16(29)8-2-13/h1-8,12,17,19,29H,9-11H2,(H2,25,30)(H,26,31)/b18-12-/t17-,19-/m0/s1 NIZUASDYXIRVRV-ZSCLYBAYSA-N 50143342 (S)-1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL292003 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1400 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143342&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299720 104032536 CHEMBL292003 ZINC29558953 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027864 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C(=C1/N=C(OC1=O)c1ccc(Br)cc1)c1ccccc1 InChI=1S/C30H27BrN4O5/c31-21-12-10-20(11-13-21)29-34-25(30(39)40-29)26(19-5-2-1-3-6-19)35-16-4-7-24(35)28(38)33-23(27(32)37)17-18-8-14-22(36)15-9-18/h1-3,5-6,8-15,23-24,36H,4,7,16-17H2,(H2,32,37)(H,33,38)/b26-25-/t23-,24-/m0/s1 PDJUHGYUPWOLMA-AFRYVWSKSA-N 50143338 (S)-1-{[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-phenyl-methyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56185 Methionine--tRNA ligase, cytoplasmic Homo sapiens 6140 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143338&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299723 104032532 CHEMBL56185 ZINC29556407 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027867 CC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C26H26Cl2N4O5/c1-2-20(22-26(36)37-25(31-22)17-10-7-15(27)13-18(17)28)32-11-3-4-21(32)24(35)30-19(23(29)34)12-14-5-8-16(33)9-6-14/h5-10,13,19,21,33H,2-4,11-12H2,1H3,(H2,29,34)(H,30,35)/b22-20-/t19-,21-/m0/s1 PNPVAJCOFSBWBY-XCAPMEMOSA-N 50143332 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL57816 Methionine--tRNA ligase, cytoplasmic Homo sapiens 180 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143332&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299509 104032526 CHEMBL57816 ZINC29559223 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027868 CCC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C26H26Cl2N4O5/c1-2-3-20(22-26(36)37-25(31-22)17-9-6-15(27)13-18(17)28)32-11-10-21(32)24(35)30-19(23(29)34)12-14-4-7-16(33)8-5-14/h4-9,13,19,21,33H,2-3,10-12H2,1H3,(H2,29,34)(H,30,35)/b22-20-/t19-,21-/m0/s1 UQCBETKZZMKPMY-XCAPMEMOSA-N 50143333 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56582 Methionine--tRNA ligase, cytoplasmic Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143333&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299508 104032527 CHEMBL56582 ZINC29554422 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027869 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1\C=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C23H20Cl2N4O5/c24-13-3-6-15(16(25)10-13)22-28-18(23(33)34-22)11-29-8-7-19(29)21(32)27-17(20(26)31)9-12-1-4-14(30)5-2-12/h1-6,10-11,17,19,30H,7-9H2,(H2,26,31)(H,27,32)/b18-11-/t17-,19-/m0/s1 DEGVHTQFXXXPCN-NLLZAZKPSA-N 50143329 (S)-1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::(S)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-1-((2-(2,4-dichlorophenyl)-5-oxooxazol-4(5H)-ylidene)methyl)azetidine-2-carboxamide::CHEMBL57382 Methionine--tRNA ligase, cytoplasmic Homo sapiens 730 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143329&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299713 104032523 CHEMBL57382 ZINC29562608 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027870 CC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C25H24Cl2N4O5/c1-2-19(21-25(35)36-24(30-21)16-8-5-14(26)12-17(16)27)31-10-9-20(31)23(34)29-18(22(28)33)11-13-3-6-15(32)7-4-13/h3-8,12,18,20,32H,2,9-11H2,1H3,(H2,28,33)(H,29,34)/b21-19-/t18-,20-/m0/s1 CCBBMWFRWVDOGI-WMWZOTROSA-N 50143330 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL55652 Methionine--tRNA ligase, cytoplasmic Homo sapiens 18 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143330&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10392245 104032524 CHEMBL55652 ZINC29549065 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027872 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C24H22Cl2N4O5/c25-14-5-8-16(17(26)11-14)23-29-19(24(34)35-23)12-30-9-1-2-20(30)22(33)28-18(21(27)32)10-13-3-6-15(31)7-4-13/h3-8,11-12,18,20,31H,1-2,9-10H2,(H2,27,32)(H,28,33)/b19-12-/t18-,20-/m0/s1 VZAJZSFYWRYCAG-IRHGGOMRSA-N 50143328 (S)-1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56024 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143328&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299744 104032522 CHEMBL56024 ZINC29552449 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027876 CC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C25H25BrN4O5/c1-2-19(21-25(34)35-24(29-21)15-5-7-16(26)8-6-15)30-12-11-20(30)23(33)28-18(22(27)32)13-14-3-9-17(31)10-4-14/h3-10,18,20,31H,2,11-13H2,1H3,(H2,27,32)(H,28,33)/b21-19-/t18-,20-/m0/s1 LLYBVIZEUYPKKP-WMWZOTROSA-N 50143337 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL59259 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143337&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299765 104032531 CHEMBL59259 ZINC29555596 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027877 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C=C1/N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C24H23BrN4O5/c25-16-7-5-15(6-8-16)23-28-19(24(33)34-23)13-29-11-1-2-20(29)22(32)27-18(21(26)31)12-14-3-9-17(30)10-4-14/h3-10,13,18,20,30H,1-2,11-12H2,(H2,26,31)(H,27,32)/b19-13-/t18-,20-/m0/s1 TWDDTXZAUZINQX-IVESEMPJSA-N 50143336 (S)-1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL299272 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1100 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143336&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299592 104032530 CHEMBL299272 ZINC29555372 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027879 CC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C26H27BrN4O5/c1-2-20(22-26(35)36-25(30-22)16-7-9-17(27)10-8-16)31-13-3-4-21(31)24(34)29-19(23(28)33)14-15-5-11-18(32)12-6-15/h5-12,19,21,32H,2-4,13-14H2,1H3,(H2,28,33)(H,29,34)/b22-20-/t19-,21-/m0/s1 GKGJGADBSLAYAC-XCAPMEMOSA-N 50143340 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL55894 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143340&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299749 104032534 CHEMBL55894 ZINC29549055 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027880 CCC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C27H28Cl2N4O5/c1-2-4-21(23-27(37)38-26(32-23)18-11-8-16(28)14-19(18)29)33-12-3-5-22(33)25(36)31-20(24(30)35)13-15-6-9-17(34)10-7-15/h6-11,14,20,22,34H,2-5,12-13H2,1H3,(H2,30,35)(H,31,36)/b23-21-/t20-,22-/m0/s1 YRTIMVMQGFBGMB-WMKNKADMSA-N 50143331 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL431521 Methionine--tRNA ligase, cytoplasmic Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143331&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299630 104032525 CHEMBL431521 ZINC29554785 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027884 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C(=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl)c1ccccc1 InChI=1S/C30H26Cl2N4O5/c31-19-10-13-21(22(32)16-19)29-35-25(30(40)41-29)26(18-5-2-1-3-6-18)36-14-4-7-24(36)28(39)34-23(27(33)38)15-17-8-11-20(37)12-9-17/h1-3,5-6,8-13,16,23-24,37H,4,7,14-15H2,(H2,33,38)(H,34,39)/b26-25-/t23-,24-/m0/s1 HKFTVJKPJYNBRB-AFRYVWSKSA-N 50143341 (S)-1-{[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-phenyl-methyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL410312 Methionine--tRNA ligase, cytoplasmic Homo sapiens 430 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143341&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299724 104032535 CHEMBL410312 ZINC29555060 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50204205 Oc1cc(NCCCNC2CCNc3c(Br)cc(Br)cc23)nc2ccccc12 InChI=1S/C21H22Br2N4O/c22-13-10-15-17(6-9-26-21(15)16(23)11-13)24-7-3-8-25-20-12-19(28)14-4-1-2-5-18(14)27-20/h1-2,4-5,10-12,17,24,26H,3,6-9H2,(H2,25,27,28) YXYUCGITAGFKSB-UHFFFAOYSA-N 50112575 2-[3-(6,8-Dibromo-1,2,3,4-tetrahydro-quinolin-4-ylamino)-propylamino]-1H-quinolin-4-one::CHEMBL304237 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1 ChEMBL 10.1021/jm025502x 10.7270/Q2HQ3Z6X 11985462 Jarvest, RL; Berge, JM; Berry, V; Boyd, HF; Brown, MJ; Elder, JS; Forrest, AK; Fosberry, AP; Gentry, DR; Hibbs, MJ; Jaworski, DD; O'Hanlon, PJ; Pope, AJ; Rittenhouse, S; Sheppard, RJ; Slater-Radosti, C; Worby, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112575&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 9935971 104006984 CHEMBL304237 ZINC09132828 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50204206 Oc1cc(NCCCNCc2ccc(Cl)c(Cl)c2)nc2ccccc12 InChI=1S/C19H19Cl2N3O/c20-15-7-6-13(10-16(15)21)12-22-8-3-9-23-19-11-18(25)14-4-1-2-5-17(14)24-19/h1-2,4-7,10-11,22H,3,8-9,12H2,(H2,23,24,25) NSDYJDCKWMOUKD-UHFFFAOYSA-N 50112576 2-(3-(3,4-dichlorobenzylamino)propylamino)quinolin-4(1H)-one::2-[3-(3,4-Dichloro-benzylamino)-propylamino]-1H-quinolin-4-one::CHEMBL60402 Methionine--tRNA ligase, cytoplasmic Homo sapiens 500 ChEMBL 10.1021/jm025502x 10.7270/Q2HQ3Z6X 11985462 Jarvest, RL; Berge, JM; Berry, V; Boyd, HF; Brown, MJ; Elder, JS; Forrest, AK; Fosberry, AP; Gentry, DR; Hibbs, MJ; Jaworski, DD; O'Hanlon, PJ; Pope, AJ; Rittenhouse, S; Sheppard, RJ; Slater-Radosti, C; Worby, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112576&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 9822999 104006985 CHEMBL60402 ZINC03923734 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50204207 CCc1cc(I)c2NCCC(NCCCNc3cc(O)c4ccccc4n3)c2c1 InChI=1S/C23H27IN4O/c1-2-15-12-17-19(8-11-27-23(17)18(24)13-15)25-9-5-10-26-22-14-21(29)16-6-3-4-7-20(16)28-22/h3-4,6-7,12-14,19,25,27H,2,5,8-11H2,1H3,(H2,26,28,29) HXYAFIKGAHUOHV-UHFFFAOYSA-N 50112577 2-[3-(6-Ethyl-8-iodo-1,2,3,4-tetrahydro-quinolin-4-ylamino)-propylamino]-1H-quinolin-4-one::CHEMBL58615 Methionine--tRNA ligase, cytoplasmic Homo sapiens 12 ChEMBL 10.1021/jm025502x 10.7270/Q2HQ3Z6X 11985462 Jarvest, RL; Berge, JM; Berry, V; Boyd, HF; Brown, MJ; Elder, JS; Forrest, AK; Fosberry, AP; Gentry, DR; Hibbs, MJ; Jaworski, DD; O'Hanlon, PJ; Pope, AJ; Rittenhouse, S; Sheppard, RJ; Slater-Radosti, C; Worby, A TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50112577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50112577&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 9892259 104006986 CHEMBL58615 ZINC09132639 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020441 Clc1ccc(c(Cl)c1)-c1ccc(cc1)-c1cc(nn1-c1cccnc1)C(=O)NCc1nnn[nH]1 InChI=1S/C23H16Cl2N8O/c24-16-7-8-18(19(25)10-16)14-3-5-15(6-4-14)21-11-20(23(34)27-13-22-28-31-32-29-22)30-33(21)17-2-1-9-26-12-17/h1-12H,13H2,(H,27,34)(H,28,29,31,32) JPMLNAZNRRYWQE-UHFFFAOYSA-N 50129527 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-yl-1H-pyrazole-3-carboxylic acid (1H-tetrazol-5-ylmethyl)-amide::CHEMBL307342 Methionine--tRNA ligase, cytoplasmic Homo sapiens 13800 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129527&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10345487 104021110 CHEMBL307342 ZINC13534774 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235664 OC(=O)c1cc(-c2ccc(cc2)-c2cccc(c2)C(O)=O)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C23H14Cl2N2O4/c24-17-8-9-20(18(25)11-17)27-21(12-19(26-27)23(30)31)14-6-4-13(5-7-14)15-2-1-3-16(10-15)22(28)29/h1-12H,(H,28,29)(H,30,31) CUQMPLKRKKPZJB-UHFFFAOYSA-N 50129525 5-(3'-Carboxy-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL306896 Methionine--tRNA ligase, cytoplasmic Homo sapiens 40900 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129525&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311506 104021108 CHEMBL306896 ZINC13534715 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020454 Clc1ccc(c(Cl)c1)-c1ccc(cc1)-c1cc(nn1-c1ccccn1)-n1cnnn1 InChI=1S/C21H13Cl2N7/c22-16-8-9-17(18(23)11-16)14-4-6-15(7-5-14)19-12-21(29-13-25-27-28-29)26-30(19)20-3-1-2-10-24-20/h1-13H XSQZDTHEDIJOJK-UHFFFAOYSA-N 50129528 2-[5-(2',4'-Dichloro-biphenyl-4-yl)-3-tetrazol-1-yl-pyrazol-1-yl]-pyridine::CHEMBL308349 Methionine--tRNA ligase, cytoplasmic Homo sapiens 25000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129528&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311501 104021111 CHEMBL308349 ZINC26288967 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020489 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(Cc2ccccn2)n1 InChI=1S/C22H15Cl2N3O2/c23-16-8-9-18(19(24)11-16)14-4-6-15(7-5-14)21-12-20(22(28)29)26-27(21)13-17-3-1-2-10-25-17/h1-12H,13H2,(H,28,29) BYEYRIKXEYOFAF-UHFFFAOYSA-N 50129548 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-2-ylmethyl-1H-pyrazole-3-carboxylic acid::CHEMBL70475 Methionine--tRNA ligase, cytoplasmic Homo sapiens 42500 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129548&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311666 104021131 CHEMBL70475 ZINC13534786 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235670 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(Cc2ccccc2)n1 InChI=1S/C23H16Cl2N2O2/c24-18-10-11-19(20(25)12-18)16-6-8-17(9-7-16)22-13-21(23(28)29)26-27(22)14-15-4-2-1-3-5-15/h1-13H,14H2,(H,28,29) JJTDTEOYDJOFKZ-UHFFFAOYSA-N 50129531 1-Benzyl-5-(2',4'-dichloro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL304044 Methionine--tRNA ligase, cytoplasmic Homo sapiens 3940 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129531&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311425 104021114 CHEMBL304044 ZINC13534749 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235672 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(Cc2cccnc2)n1 InChI=1S/C22H15Cl2N3O2/c23-17-7-8-18(19(24)10-17)15-3-5-16(6-4-15)21-11-20(22(28)29)26-27(21)13-14-2-1-9-25-12-14/h1-12H,13H2,(H,28,29) DJIZQXACFIGGIL-UHFFFAOYSA-N 50129533 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-ylmethyl-1H-pyrazole-3-carboxylic acid::CHEMBL304618 Methionine--tRNA ligase, cytoplasmic Homo sapiens 660.0 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129533&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311665 104021116 CHEMBL304618 ZINC13534789 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235673 OC(=O)c1cc(n[nH]1)-c1ccc(cc1)-c1ccc(Cl)cc1Cl InChI=1S/C16H10Cl2N2O2/c17-11-5-6-12(13(18)7-11)9-1-3-10(4-2-9)14-8-15(16(21)22)20-19-14/h1-8H,(H,19,20)(H,21,22) SIKKXNVXBDJNHW-UHFFFAOYSA-N 50129535 5-(2',4'-Dichloro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL442177 Methionine--tRNA ligase, cytoplasmic Homo sapiens 3280 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129535&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311524 104021118 CHEMBL442177 ZINC13534728 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235676 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(F)c(Cl)c2)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C22H12Cl3FN2O2/c23-15-6-8-20(17(25)10-15)28-21(11-19(27-28)22(29)30)13-3-1-12(2-4-13)14-5-7-18(26)16(24)9-14/h1-11H,(H,29,30) SCEUFRHFXREEGO-UHFFFAOYSA-N 50129538 5-(3'-Chloro-4'-fluoro-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL70536 Methionine--tRNA ligase, cytoplasmic Homo sapiens 20900 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129538&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311484 104021121 CHEMBL70536 ZINC13534712 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235677 COc1ccccc1-n1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)-n1cnnn1 InChI=1S/C23H16Cl2N6O/c1-32-22-5-3-2-4-20(22)31-21(13-23(27-31)30-14-26-28-29-30)16-8-6-15(7-9-16)18-11-10-17(24)12-19(18)25/h2-14H,1H3 WTPNTZOWQPAUOJ-UHFFFAOYSA-N 50129539 1-[5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2-methoxy-phenyl)-1H-pyrazol-3-yl]-1H-tetrazole::CHEMBL304562 Methionine--tRNA ligase, cytoplasmic Homo sapiens 20000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129539&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311483 104021122 CHEMBL304562 ZINC26294076 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235678 COc1ccc(cc1)-n1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C23H16Cl2N2O3/c1-30-18-9-7-17(8-10-18)27-22(13-21(26-27)23(28)29)15-4-2-14(3-5-15)19-11-6-16(24)12-20(19)25/h2-13H,1H3,(H,28,29) SVPDZVRKFOHCKQ-UHFFFAOYSA-N 50129537 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL71745 Methionine--tRNA ligase, cytoplasmic Homo sapiens 10500 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129537&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311426 104021120 CHEMBL71745 ZINC13534746 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020490 OC(=O)Cn1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C18H12Cl2N2O4/c19-12-5-6-13(14(20)7-12)10-1-3-11(4-2-10)16-8-15(18(25)26)21-22(16)9-17(23)24/h1-8H,9H2,(H,23,24)(H,25,26) GKJVIHOFGGUSRG-UHFFFAOYSA-N 50129554 1-Carboxymethyl-5-(2',4'-dichloro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL71727 Methionine--tRNA ligase, cytoplasmic Homo sapiens 100000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129554&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311466 104021137 CHEMBL71727 ZINC13534759 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235686 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccccc1 InChI=1S/C22H14Cl2N2O2/c23-16-10-11-18(19(24)12-16)14-6-8-15(9-7-14)21-13-20(22(27)28)25-26(21)17-4-2-1-3-5-17/h1-13H,(H,27,28) DUZSYBIDFHTHGJ-UHFFFAOYSA-N 50129545 5-(2',4'-Dichloro-biphenyl-4-yl)-1-phenyl-1H-pyrazole-3-carboxylic acid::CHEMBL70982 Methionine--tRNA ligase, cytoplasmic Homo sapiens 5470.0 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129545&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311608 104021128 CHEMBL70982 ZINC13534731 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235687 OCCn1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C18H14Cl2N2O3/c19-13-5-6-14(15(20)9-13)11-1-3-12(4-2-11)17-10-16(18(24)25)21-22(17)7-8-23/h1-6,9-10,23H,7-8H2,(H,24,25) LDQUUHYSEIMRAJ-UHFFFAOYSA-N 50129540 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2-hydroxy-ethyl)-1H-pyrazole-3-carboxylic acid::CHEMBL74009 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129540&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311478 104021123 CHEMBL74009 ZINC13534756 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235692 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1cccnc1 InChI=1S/C21H13Cl2N3O2/c22-15-7-8-17(18(23)10-15)13-3-5-14(6-4-13)20-11-19(21(27)28)25-26(20)16-2-1-9-24-12-16/h1-12H,(H,27,28) XFMAKVCFFOHWFZ-UHFFFAOYSA-N 50129534 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-yl-1H-pyrazole-3-carboxylic acid::CHEMBL307660 Methionine--tRNA ligase, cytoplasmic Homo sapiens 47000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129534&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311709 104021117 CHEMBL307660 ZINC13534765 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235695 COc1ccccc1-n1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C23H16Cl2N2O3/c1-30-22-5-3-2-4-20(22)27-21(13-19(26-27)23(28)29)15-8-6-14(7-9-15)17-11-10-16(24)12-18(17)25/h2-13H,1H3,(H,28,29) NVPPSSQYDZGMIQ-UHFFFAOYSA-N 50129544 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL307466 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1510 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129544&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311427 104021127 CHEMBL307466 ZINC13534741 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235699 OC(=O)c1cc(nn1Cc1cccnc1)-c1ccc(cc1)-c1ccc(Cl)cc1Cl InChI=1S/C22H15Cl2N3O2/c23-17-7-8-18(19(24)10-17)15-3-5-16(6-4-15)20-11-21(22(28)29)27(26-20)13-14-2-1-9-25-12-14/h1-12H,13H2,(H,28,29) DXUVKUBMVJGOOH-UHFFFAOYSA-N 50129543 5-(2',4'-Dichloro-biphenyl-4-yl)-2-pyridin-3-ylmethyl-2H-pyrazole-3-carboxylic acid::CHEMBL71729 Methionine--tRNA ligase, cytoplasmic Homo sapiens 19900 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129543&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311541 104021126 CHEMBL71729 ZINC13534801 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235704 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(Cc2ccccn2)n1 InChI=1S/C22H15Cl2N3O2/c23-16-8-9-18(19(24)11-16)14-4-6-15(7-5-14)21-12-20(22(28)29)26-27(21)13-17-3-1-2-10-25-17/h1-12H,13H2,(H,28,29) BYEYRIKXEYOFAF-UHFFFAOYSA-N 50129548 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-2-ylmethyl-1H-pyrazole-3-carboxylic acid::CHEMBL70475 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1340 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129548&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311666 104021131 CHEMBL70475 ZINC13534786 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235713 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(Cc2ccncc2)n1 InChI=1S/C22H15Cl2N3O2/c23-17-5-6-18(19(24)11-17)15-1-3-16(4-2-15)21-12-20(22(28)29)26-27(21)13-14-7-9-25-10-8-14/h1-12H,13H2,(H,28,29) BGJWGJFNDKCBQB-UHFFFAOYSA-N 50129553 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-4-ylmethyl-1H-pyrazole-3-carboxylic acid::CHEMBL308309 Methionine--tRNA ligase, cytoplasmic Homo sapiens 500 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129553&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311523 104021136 CHEMBL308309 ZINC13534793 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235718 OC(=O)c1cc(nn1Cc1ccncc1)-c1ccc(cc1)-c1ccc(Cl)cc1Cl InChI=1S/C22H15Cl2N3O2/c23-17-5-6-18(19(24)11-17)15-1-3-16(4-2-15)20-12-21(22(28)29)27(26-20)13-14-7-9-25-10-8-14/h1-12H,13H2,(H,28,29) GPVVPUOBZYOOQV-UHFFFAOYSA-N 50129550 5-(2',4'-Dichloro-biphenyl-4-yl)-2-pyridin-4-ylmethyl-2H-pyrazole-3-carboxylic acid::CHEMBL73305 Methionine--tRNA ligase, cytoplasmic Homo sapiens 910.0 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129550&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311687 104021133 CHEMBL73305 ZINC13534805 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235722 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C23H13Cl2F3N2O2/c24-17-9-10-20(18(25)11-17)30-21(12-19(29-30)22(31)32)15-3-1-13(2-4-15)14-5-7-16(8-6-14)23(26,27)28/h1-12H,(H,31,32) VISMJIFBVJNJRQ-UHFFFAOYSA-N 50129549 1-(2,4-Dichloro-phenyl)-5-(4'-trifluoromethyl-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL303469 Methionine--tRNA ligase, cytoplasmic Homo sapiens 33900 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129549&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311507 104021132 CHEMBL303469 ZINC13534718 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235723 OC(=O)c1cc(nn1Cc1ccccn1)-c1ccc(cc1)-c1ccc(Cl)cc1Cl InChI=1S/C22H15Cl2N3O2/c23-16-8-9-18(19(24)11-16)14-4-6-15(7-5-14)20-12-21(22(28)29)27(26-20)13-17-3-1-2-10-25-17/h1-12H,13H2,(H,28,29) BLKMMQBUPKVNSE-UHFFFAOYSA-N 50129542 5-(2',4'-Dichloro-biphenyl-4-yl)-2-pyridin-2-ylmethyl-2H-pyrazole-3-carboxylic acid::CHEMBL72038 Methionine--tRNA ligase, cytoplasmic Homo sapiens 22300 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129542&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311542 104021125 CHEMBL72038 ZINC13534797 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235727 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C22H12Cl4N2O2/c23-14-5-7-16(17(25)9-14)12-1-3-13(4-2-12)21-11-19(22(29)30)27-28(21)20-8-6-15(24)10-18(20)26/h1-11H,(H,29,30) GRDGNNDMWJNVER-UHFFFAOYSA-N 50129536 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL70567 Methionine--tRNA ligase, cytoplasmic Homo sapiens 11900 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129536&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311186 104021119 CHEMBL70567 ZINC13534708 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235728 OC(=O)Cn1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C18H12Cl2N2O4/c19-12-5-6-13(14(20)7-12)10-1-3-11(4-2-10)16-8-15(18(25)26)21-22(16)9-17(23)24/h1-8H,9H2,(H,23,24)(H,25,26) GKJVIHOFGGUSRG-UHFFFAOYSA-N 50129554 1-Carboxymethyl-5-(2',4'-dichloro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL71727 Methionine--tRNA ligase, cytoplasmic Homo sapiens 3420 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129554&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311466 104021137 CHEMBL71727 ZINC13534759 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027855 CC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C26H27BrN4O5/c1-2-20(22-26(35)36-25(30-22)16-7-9-17(27)10-8-16)31-13-3-4-21(31)24(34)29-19(23(28)33)14-15-5-11-18(32)12-6-15/h5-12,19,21,32H,2-4,13-14H2,1H3,(H2,28,33)(H,29,34)/b22-20-/t19-,21-/m0/s1 GKGJGADBSLAYAC-XCAPMEMOSA-N 50143340 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL55894 Methionine--tRNA ligase, cytoplasmic Homo sapiens 5930 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143340&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299749 104032534 CHEMBL55894 ZINC29549055 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027856 CC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C25H25BrN4O5/c1-2-19(21-25(34)35-24(29-21)15-5-7-16(26)8-6-15)30-12-11-20(30)23(33)28-18(22(27)32)13-14-3-9-17(31)10-4-14/h3-10,18,20,31H,2,11-13H2,1H3,(H2,27,32)(H,28,33)/b21-19-/t18-,20-/m0/s1 LLYBVIZEUYPKKP-WMWZOTROSA-N 50143337 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL59259 Methionine--tRNA ligase, cytoplasmic Homo sapiens 99000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143337&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299765 104032531 CHEMBL59259 ZINC29555596 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027857 C\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C25H24Cl2N4O5/c1-13(21-25(35)36-24(30-21)17-9-6-15(26)12-18(17)27)31-10-2-3-20(31)23(34)29-19(22(28)33)11-14-4-7-16(32)8-5-14/h4-9,12,19-20,32H,2-3,10-11H2,1H3,(H2,28,33)(H,29,34)/b21-13-/t19-,20-/m0/s1 HPSQELPNVYWIJX-CMBLOLPWSA-N 50143343 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-ethyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL293288 Methionine--tRNA ligase, cytoplasmic Homo sapiens 6630 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143343&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299532 104032537 CHEMBL293288 ZINC29556384 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027858 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C(=C1/N=C(OC1=O)c1ccc(Br)cc1)c1ccccc1 InChI=1S/C30H27BrN4O5/c31-21-12-10-20(11-13-21)29-34-25(30(39)40-29)26(19-5-2-1-3-6-19)35-16-4-7-24(35)28(38)33-23(27(32)37)17-18-8-14-22(36)15-9-18/h1-3,5-6,8-15,23-24,36H,4,7,16-17H2,(H2,32,37)(H,33,38)/b26-25-/t23-,24-/m0/s1 PDJUHGYUPWOLMA-AFRYVWSKSA-N 50143338 (S)-1-{[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-phenyl-methyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56185 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143338&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299723 104032532 CHEMBL56185 ZINC29556407 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027859 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1\C=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C23H20Cl2N4O5/c24-13-3-6-15(16(25)10-13)22-28-18(23(33)34-22)11-29-8-7-19(29)21(32)27-17(20(26)31)9-12-1-4-14(30)5-2-12/h1-6,10-11,17,19,30H,7-9H2,(H2,26,31)(H,27,32)/b18-11-/t17-,19-/m0/s1 DEGVHTQFXXXPCN-NLLZAZKPSA-N 50143329 (S)-1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::(S)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-1-((2-(2,4-dichlorophenyl)-5-oxooxazol-4(5H)-ylidene)methyl)azetidine-2-carboxamide::CHEMBL57382 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143329&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299713 104032523 CHEMBL57382 ZINC29562608 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027860 CCC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C26H27BrN4O5/c1-2-3-20(22-26(35)36-25(30-22)16-6-8-17(27)9-7-16)31-13-12-21(31)24(34)29-19(23(28)33)14-15-4-10-18(32)11-5-15/h4-11,19,21,32H,2-3,12-14H2,1H3,(H2,28,33)(H,29,34)/b22-20-/t19-,21-/m0/s1 RHJZRYHUIOAIPC-XCAPMEMOSA-N 50143334 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL59204 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143334&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299531 104032528 CHEMBL59204 ZINC29556380 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027862 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C24H22Cl2N4O5/c25-14-5-8-16(17(26)11-14)23-29-19(24(34)35-23)12-30-9-1-2-20(30)22(33)28-18(21(27)32)10-13-3-6-15(31)7-4-13/h3-8,11-12,18,20,31H,1-2,9-10H2,(H2,27,32)(H,28,33)/b19-12-/t18-,20-/m0/s1 VZAJZSFYWRYCAG-IRHGGOMRSA-N 50143328 (S)-1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56024 Methionine--tRNA ligase, cytoplasmic Homo sapiens 14000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143328&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299744 104032522 CHEMBL56024 ZINC29552449 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027865 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1\C=C1/N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C23H21BrN4O5/c24-15-5-3-14(4-6-15)22-27-18(23(32)33-22)12-28-10-9-19(28)21(31)26-17(20(25)30)11-13-1-7-16(29)8-2-13/h1-8,12,17,19,29H,9-11H2,(H2,25,30)(H,26,31)/b18-12-/t17-,19-/m0/s1 NIZUASDYXIRVRV-ZSCLYBAYSA-N 50143342 (S)-1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL292003 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143342&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299720 104032536 CHEMBL292003 ZINC29558953 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027866 CCC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C27H29BrN4O5/c1-2-4-21(23-27(36)37-26(31-23)17-8-10-18(28)11-9-17)32-14-3-5-22(32)25(35)30-20(24(29)34)15-16-6-12-19(33)13-7-16/h6-13,20,22,33H,2-5,14-15H2,1H3,(H2,29,34)(H,30,35)/b23-21-/t20-,22-/m0/s1 YKFJRHPAYFCCSS-WMKNKADMSA-N 50143339 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL292230 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143339&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299523 104032533 CHEMBL292230 ZINC29553683 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027871 C\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C25H25BrN4O5/c1-14(21-25(34)35-24(29-21)16-6-8-17(26)9-7-16)30-12-2-3-20(30)23(33)28-19(22(27)32)13-15-4-10-18(31)11-5-15/h4-11,19-20,31H,2-3,12-13H2,1H3,(H2,27,32)(H,28,33)/b21-14-/t19-,20-/m0/s1 ACKYJUCEEPBWJV-MSWATVTMSA-N 50143335 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-ethyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56463 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143335&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299527 104032529 CHEMBL56463 ZINC29555238 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027873 CC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C25H24Cl2N4O5/c1-2-19(21-25(35)36-24(30-21)16-8-5-14(26)12-17(16)27)31-10-9-20(31)23(34)29-18(22(28)33)11-13-3-6-15(32)7-4-13/h3-8,12,18,20,32H,2,9-11H2,1H3,(H2,28,33)(H,29,34)/b21-19-/t18-,20-/m0/s1 CCBBMWFRWVDOGI-WMWZOTROSA-N 50143330 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL55652 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143330&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10392245 104032524 CHEMBL55652 ZINC29549065 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027874 CCC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C27H29BrN4O5/c1-2-4-21(23-27(36)37-26(31-23)17-8-10-18(28)11-9-17)32-14-3-5-22(32)25(35)30-20(24(29)34)15-16-6-12-19(33)13-7-16/h6-13,20,22,33H,2-5,14-15H2,1H3,(H2,29,34)(H,30,35)/b23-21-/t20-,22-/m0/s1 YKFJRHPAYFCCSS-WMKNKADMSA-N 50143339 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL292230 Methionine--tRNA ligase, cytoplasmic Homo sapiens 3110 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143339&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299523 104032533 CHEMBL292230 ZINC29553683 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027875 CC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C25H24Cl2N4O5/c1-2-19(21-25(35)36-24(30-21)16-8-5-14(26)12-17(16)27)31-10-9-20(31)23(34)29-18(22(28)33)11-13-3-6-15(32)7-4-13/h3-8,12,18,20,32H,2,9-11H2,1H3,(H2,28,33)(H,29,34)/b21-19-/t18-,20-/m0/s1 CCBBMWFRWVDOGI-WMWZOTROSA-N 50143330 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL55652 Methionine--tRNA ligase, cytoplasmic Homo sapiens 3510 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143330&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10392245 104032524 CHEMBL55652 ZINC29549065 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027878 C\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C25H25BrN4O5/c1-14(21-25(34)35-24(29-21)16-6-8-17(26)9-7-16)30-12-2-3-20(30)23(33)28-19(22(27)32)13-15-4-10-18(31)11-5-15/h4-11,19-20,31H,2-3,12-13H2,1H3,(H2,27,32)(H,28,33)/b21-14-/t19-,20-/m0/s1 ACKYJUCEEPBWJV-MSWATVTMSA-N 50143335 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-ethyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56463 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143335&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299527 104032529 CHEMBL56463 ZINC29555238 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027881 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C=C1/N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C24H23BrN4O5/c25-16-7-5-15(6-8-16)23-28-19(24(33)34-23)13-29-11-1-2-20(29)22(32)27-18(21(26)31)12-14-3-9-17(30)10-4-14/h3-10,13,18,20,30H,1-2,11-12H2,(H2,26,31)(H,27,32)/b19-13-/t18-,20-/m0/s1 TWDDTXZAUZINQX-IVESEMPJSA-N 50143336 (S)-1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL299272 Methionine--tRNA ligase, cytoplasmic Homo sapiens 48000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143336&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299592 104032530 CHEMBL299272 ZINC29555372 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027882 CC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C26H26Cl2N4O5/c1-2-20(22-26(36)37-25(31-22)17-10-7-15(27)13-18(17)28)32-11-3-4-21(32)24(35)30-19(23(29)34)12-14-5-8-16(33)9-6-14/h5-10,13,19,21,33H,2-4,11-12H2,1H3,(H2,29,34)(H,30,35)/b22-20-/t19-,21-/m0/s1 PNPVAJCOFSBWBY-XCAPMEMOSA-N 50143332 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL57816 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143332&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299509 104032526 CHEMBL57816 ZINC29559223 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50027883 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C24H22Cl2N4O5/c25-14-5-8-16(17(26)11-14)23-29-19(24(34)35-23)12-30-9-1-2-20(30)22(33)28-18(21(27)32)10-13-3-6-15(31)7-4-13/h3-8,11-12,18,20,31H,1-2,9-10H2,(H2,27,32)(H,28,33)/b19-12-/t18-,20-/m0/s1 VZAJZSFYWRYCAG-IRHGGOMRSA-N 50143328 (S)-1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56024 Methionine--tRNA ligase, cytoplasmic Homo sapiens 680 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143328&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299744 104032522 CHEMBL56024 ZINC29552449 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263455 CCC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C27H28Cl2N4O5/c1-2-4-21(23-27(37)38-26(32-23)18-11-8-16(28)14-19(18)29)33-12-3-5-22(33)25(36)31-20(24(30)35)13-15-6-9-17(34)10-7-15/h6-11,14,20,22,34H,2-5,12-13H2,1H3,(H2,30,35)(H,31,36)/b23-21-/t20-,22-/m0/s1 YRTIMVMQGFBGMB-WMKNKADMSA-N 50143331 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL431521 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143331&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299630 104032525 CHEMBL431521 ZINC29554785 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263463 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C(=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl)c1ccccc1 InChI=1S/C30H26Cl2N4O5/c31-19-10-13-21(22(32)16-19)29-35-25(30(40)41-29)26(18-5-2-1-3-6-18)36-14-4-7-24(36)28(39)34-23(27(33)38)15-17-8-11-20(37)12-9-17/h1-3,5-6,8-13,16,23-24,37H,4,7,14-15H2,(H2,33,38)(H,34,39)/b26-25-/t23-,24-/m0/s1 HKFTVJKPJYNBRB-AFRYVWSKSA-N 50143341 (S)-1-{[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-phenyl-methyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL410312 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143341&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299724 104032535 CHEMBL410312 ZINC29555060 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263468 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C(=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl)c1ccccc1 InChI=1S/C30H26Cl2N4O5/c31-19-10-13-21(22(32)16-19)29-35-25(30(40)41-29)26(18-5-2-1-3-6-18)36-14-4-7-24(36)28(39)34-23(27(33)38)15-17-8-11-20(37)12-9-17/h1-3,5-6,8-13,16,23-24,37H,4,7,14-15H2,(H2,33,38)(H,34,39)/b26-25-/t23-,24-/m0/s1 HKFTVJKPJYNBRB-AFRYVWSKSA-N 50143341 (S)-1-{[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-phenyl-methyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL410312 Methionine--tRNA ligase, cytoplasmic Homo sapiens 27400 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143341&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299724 104032535 CHEMBL410312 ZINC29555060 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263469 CCC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C27H28Cl2N4O5/c1-2-4-21(23-27(37)38-26(32-23)18-11-8-16(28)14-19(18)29)33-12-3-5-22(33)25(36)31-20(24(30)35)13-15-6-9-17(34)10-7-15/h6-11,14,20,22,34H,2-5,12-13H2,1H3,(H2,30,35)(H,31,36)/b23-21-/t20-,22-/m0/s1 YRTIMVMQGFBGMB-WMKNKADMSA-N 50143331 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL431521 Methionine--tRNA ligase, cytoplasmic Homo sapiens 99000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143331&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299630 104032525 CHEMBL431521 ZINC29554785 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263471 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1\C=C1/N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C23H21BrN4O5/c24-15-5-3-14(4-6-15)22-27-18(23(32)33-22)12-28-10-9-19(28)21(31)26-17(20(25)30)11-13-1-7-16(29)8-2-13/h1-8,12,17,19,29H,9-11H2,(H2,25,30)(H,26,31)/b18-12-/t17-,19-/m0/s1 NIZUASDYXIRVRV-ZSCLYBAYSA-N 50143342 (S)-1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL292003 Methionine--tRNA ligase, cytoplasmic Homo sapiens 510 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143342&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299720 104032536 CHEMBL292003 ZINC29558953 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263473 CC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C26H27BrN4O5/c1-2-20(22-26(35)36-25(30-22)16-7-9-17(27)10-8-16)31-13-3-4-21(31)24(34)29-19(23(28)33)14-15-5-11-18(32)12-6-15/h5-12,19,21,32H,2-4,13-14H2,1H3,(H2,28,33)(H,29,34)/b22-20-/t19-,21-/m0/s1 GKGJGADBSLAYAC-XCAPMEMOSA-N 50143340 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL55894 Methionine--tRNA ligase, cytoplasmic Homo sapiens 850 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143340&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299749 104032534 CHEMBL55894 ZINC29549055 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263474 CC\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C26H26Cl2N4O5/c1-2-20(22-26(36)37-25(31-22)17-10-7-15(27)13-18(17)28)32-11-3-4-21(32)24(35)30-19(23(29)34)12-14-5-8-16(33)9-6-14/h5-10,13,19,21,33H,2-4,11-12H2,1H3,(H2,29,34)(H,30,35)/b22-20-/t19-,21-/m0/s1 PNPVAJCOFSBWBY-XCAPMEMOSA-N 50143332 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL57816 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1280 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143332&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299509 104032526 CHEMBL57816 ZINC29559223 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263476 CCC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C26H26Cl2N4O5/c1-2-3-20(22-26(36)37-25(31-22)17-9-6-15(27)13-18(17)28)32-11-10-21(32)24(35)30-19(23(29)34)12-14-4-7-16(33)8-5-14/h4-9,13,19,21,33H,2-3,10-12H2,1H3,(H2,29,34)(H,30,35)/b22-20-/t19-,21-/m0/s1 UQCBETKZZMKPMY-XCAPMEMOSA-N 50143333 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56582 Methionine--tRNA ligase, cytoplasmic Homo sapiens 3520 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143333&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299508 104032527 CHEMBL56582 ZINC29554422 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263482 CCC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C26H26Cl2N4O5/c1-2-3-20(22-26(36)37-25(31-22)17-9-6-15(27)13-18(17)28)32-11-10-21(32)24(35)30-19(23(29)34)12-14-4-7-16(33)8-5-14/h4-9,13,19,21,33H,2-3,10-12H2,1H3,(H2,29,34)(H,30,35)/b22-20-/t19-,21-/m0/s1 UQCBETKZZMKPMY-XCAPMEMOSA-N 50143333 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56582 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143333&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299508 104032527 CHEMBL56582 ZINC29554422 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263485 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCN1\C=C1/N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C23H20Cl2N4O5/c24-13-3-6-15(16(25)10-13)22-28-18(23(33)34-22)11-29-8-7-19(29)21(32)27-17(20(26)31)9-12-1-4-14(30)5-2-12/h1-6,10-11,17,19,30H,7-9H2,(H2,26,31)(H,27,32)/b18-11-/t17-,19-/m0/s1 DEGVHTQFXXXPCN-NLLZAZKPSA-N 50143329 (S)-1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidenemethyl]-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::(S)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-1-((2-(2,4-dichlorophenyl)-5-oxooxazol-4(5H)-ylidene)methyl)azetidine-2-carboxamide::CHEMBL57382 Methionine--tRNA ligase, cytoplasmic Homo sapiens 70 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143329&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299713 104032523 CHEMBL57382 ZINC29562608 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263493 C\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C25H24Cl2N4O5/c1-13(21-25(35)36-24(30-21)17-9-6-15(26)12-18(17)27)31-10-2-3-20(31)23(34)29-19(22(28)33)11-14-4-7-16(32)8-5-14/h4-9,12,19-20,32H,2-3,10-11H2,1H3,(H2,28,33)(H,29,34)/b21-13-/t19-,20-/m0/s1 HPSQELPNVYWIJX-CMBLOLPWSA-N 50143343 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-ethyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL293288 Methionine--tRNA ligase, cytoplasmic Homo sapiens 340 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143343&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299532 104032537 CHEMBL293288 ZINC29556384 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263497 CC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C25H25BrN4O5/c1-2-19(21-25(34)35-24(29-21)15-5-7-16(26)8-6-15)30-12-11-20(30)23(33)28-18(22(27)32)13-14-3-9-17(31)10-4-14/h3-10,18,20,31H,2,11-13H2,1H3,(H2,27,32)(H,28,33)/b21-19-/t18-,20-/m0/s1 LLYBVIZEUYPKKP-WMWZOTROSA-N 50143337 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-propyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL59259 Methionine--tRNA ligase, cytoplasmic Homo sapiens 170 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143337&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299765 104032531 CHEMBL59259 ZINC29555596 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263498 CCC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C26H27BrN4O5/c1-2-3-20(22-26(35)36-25(30-22)16-6-8-17(27)9-7-16)31-13-12-21(31)24(34)29-19(23(28)33)14-15-4-10-18(32)11-5-15/h4-11,19,21,32H,2-3,12-14H2,1H3,(H2,28,33)(H,29,34)/b22-20-/t19-,21-/m0/s1 RHJZRYHUIOAIPC-XCAPMEMOSA-N 50143334 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL59204 Methionine--tRNA ligase, cytoplasmic Homo sapiens 87 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143334&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299531 104032528 CHEMBL59204 ZINC29556380 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263501 NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1\C(=C1/N=C(OC1=O)c1ccc(Br)cc1)c1ccccc1 InChI=1S/C30H27BrN4O5/c31-21-12-10-20(11-13-21)29-34-25(30(39)40-29)26(19-5-2-1-3-6-19)35-16-4-7-24(35)28(38)33-23(27(32)37)17-18-8-14-22(36)15-9-18/h1-3,5-6,8-15,23-24,36H,4,7,16-17H2,(H2,32,37)(H,33,38)/b26-25-/t23-,24-/m0/s1 PDJUHGYUPWOLMA-AFRYVWSKSA-N 50143338 (S)-1-{[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-phenyl-methyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL56185 Methionine--tRNA ligase, cytoplasmic Homo sapiens 810 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143338&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299723 104032532 CHEMBL56185 ZINC29556407 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263461 CCC\C(N1CC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Br)cc1 InChI=1S/C26H27BrN4O5/c1-2-3-20(22-26(35)36-25(30-22)16-6-8-17(27)9-7-16)31-13-12-21(31)24(34)29-19(23(28)33)14-15-4-10-18(32)11-5-15/h4-11,19,21,32H,2-3,12-14H2,1H3,(H2,28,33)(H,29,34)/b22-20-/t19-,21-/m0/s1 RHJZRYHUIOAIPC-XCAPMEMOSA-N 50143334 (S)-1-{1-[2-(4-Bromo-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-butyl}-azetidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL59204 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143334&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299531 104032528 CHEMBL59204 ZINC29556380 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50263483 C\C(N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)=C1\N=C(OC1=O)c1ccc(Cl)cc1Cl InChI=1S/C25H24Cl2N4O5/c1-13(21-25(35)36-24(30-21)17-9-6-15(26)12-18(17)27)31-10-2-3-20(31)23(34)29-19(22(28)33)11-14-4-7-16(32)8-5-14/h4-9,12,19-20,32H,2-3,10-11H2,1H3,(H2,28,33)(H,29,34)/b21-13-/t19-,20-/m0/s1 HPSQELPNVYWIJX-CMBLOLPWSA-N 50143343 (S)-1-{1-[2-(2,4-Dichloro-phenyl)-5-oxo-oxazol-(4Z)-ylidene]-ethyl}-pyrrolidine-2-carboxylic acid [(S)-1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-amide::CHEMBL293288 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/j.bmcl.2004.01.094 10.7270/Q2NG4Q2F 15050625 Tandon, M; Coffen, DL; Gallant, P; Keith, D; Ashwell, MA ArQule Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143343&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44299532 104032537 CHEMBL293288 ZINC29556384 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735265 CSCC[C@H]([NH3+])C(=O)OC[C@H]1O[C@@H](Cn2nnc(n2)-c2ccccc2)[C@H](O)[C@@H]1O InChI=1S/C18H25N5O5S/c1-29-8-7-12(19)18(26)27-10-14-16(25)15(24)13(28-14)9-23-21-17(20-22-23)11-5-3-2-4-6-11/h2-6,12-16,24-25H,7-10,19H2,1H3/p+1/t12-,13-,14+,15-,16+/m0/s1 OPIHXWVUVGMBDV-ARKGTOAJSA-O 50099068 (S)-1-[(2R,3S,4R,5S)-3,4-Dihydroxy-5-(5-phenyl-tetrazol-2-ylmethyl)-tetrahydro-furan-2-ylmethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 12200 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099068&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44386335 103995991 C03317 ZINC28099641 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735266 CSCC[C@H]([NH3+])C(=O)N(O)C[C@H]1O[C@@H](CCn2cnc3c(NCc4ccccc4)ncnc23)[C@H](O)[C@@H]1O InChI=1S/C24H33N7O5S/c1-37-10-8-16(25)24(34)31(35)12-18-21(33)20(32)17(36-18)7-9-30-14-29-19-22(27-13-28-23(19)30)26-11-15-5-3-2-4-6-15/h2-6,13-14,16-18,20-21,32-33,35H,7-12,25H2,1H3,(H,26,27,28)/p+1/t16-,17-,18+,20-,21+/m0/s1 ADHOTZPMNQMLNR-GCGJSEPQSA-O 50099069 (S)-1-({(2R,3S,4R,5S)-5-[2-(6-Benzylamino-purin-9-yl)-ethyl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl}-hydroxy-carbamoyl)-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 23000 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099069&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44386353 103995992 ZINC28092880 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735267 CSCC[C@H]([NH3+])C(=O)N(O)C[C@H]1O[C@@H](CCn2cnc3c(N)ncnc23)[C@H](O)[C@@H]1O InChI=1S/C17H27N7O5S/c1-30-5-3-9(18)17(27)24(28)6-11-14(26)13(25)10(29-11)2-4-23-8-22-12-15(19)20-7-21-16(12)23/h7-11,13-14,25-26,28H,2-6,18H2,1H3,(H2,19,20,21)/p+1/t9-,10-,11+,13-,14+/m0/s1 IHSLRYXBRZXISD-CVNCSBKSSA-O 50099070 (S)-1-({(2R,3S,4R,5S)-5-[2-(6-Amino-purin-9-yl)-ethyl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl}-hydroxy-carbamoyl)-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 56000 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099070&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385587 103995993 ZINC28087981 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735273 CSCC[C@H]([NH3+])C(=O)N(O)C[C@H]1O[C@@H](Cn2cnc3c(N)ncnc23)[C@H](O)[C@@H]1O InChI=1S/C16H25N7O5S/c1-29-3-2-8(17)16(26)23(27)5-10-13(25)12(24)9(28-10)4-22-7-21-11-14(18)19-6-20-15(11)22/h6-10,12-13,24-25,27H,2-5,17H2,1H3,(H2,18,19,20)/p+1/t8-,9-,10+,12-,13+/m0/s1 VINQRXNVALRROK-VKISENBKSA-O 50099076 (S)-1-{[(2R,3S,4R,5S)-5-(6-Amino-purin-9-ylmethyl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-hydroxy-carbamoyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 26000 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099076&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385357 103995999 ZINC28013323 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735276 CSCC[C@H]([NH3+])C(=O)N(O)C[C@H]1O[C@@H](CCn2nnc(n2)-c2ccccc2)[C@H](O)[C@@H]1O InChI=1S/C19H28N6O5S/c1-31-10-8-13(20)19(28)24(29)11-15-17(27)16(26)14(30-15)7-9-25-22-18(21-23-25)12-5-3-2-4-6-12/h2-6,13-17,26-27,29H,7-11,20H2,1H3/p+1/t13-,14-,15+,16-,17+/m0/s1 ZXYHDDBYHYKLSF-ZOFXXKQRSA-O 50099079 (S)-1-({(2R,3S,4R,5S)-3,4-Dihydroxy-5-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furan-2-ylmethyl}-hydroxy-carbamoyl)-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 34000 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099079&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385530 103996002 ZINC28091336 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735277 CSCC[C@H]([NH3+])C(=O)N(O)C[C@H]1O[C@@H](Cn2nnc(n2)-c2ccccc2)[C@H](O)[C@@H]1O InChI=1S/C18H26N6O5S/c1-30-8-7-12(19)18(27)23(28)9-13-15(25)16(26)14(29-13)10-24-21-17(20-22-24)11-5-3-2-4-6-11/h2-6,12-16,25-26,28H,7-10,19H2,1H3/p+1/t12-,13+,14-,15+,16-/m0/s1 QBXRNSBDHMHRQY-NPJQDHAYSA-O 50099080 (S)-1-{[(2R,3S,4R,5S)-3,4-Dihydroxy-5-(5-phenyl-tetrazol-2-ylmethyl)-tetrahydro-furan-2-ylmethyl]-hydroxy-carbamoyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 17000 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099080 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099080&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44386073 103996003 ZINC28096656 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735279 CSCC[C@H]([NH3+])C(=O)OC[C@H]1O[C@@H](Cn2cnc3c(NCc4ccccc4)ncnc23)[C@H](O)[C@@H]1O InChI=1S/C23H30N6O5S/c1-35-8-7-15(24)23(32)33-11-17-20(31)19(30)16(34-17)10-29-13-28-18-21(26-12-27-22(18)29)25-9-14-5-3-2-4-6-14/h2-6,12-13,15-17,19-20,30-31H,7-11,24H2,1H3,(H,25,26,27)/p+1/t15-,16-,17+,19-,20+/m0/s1 OIVUXUKDAFEGOV-VBYALHQYSA-O 50099083 (S)-1-[(2R,3S,4R,5S)-5-(6-Benzylamino-purin-9-ylmethyl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 16500 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099083&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44386341 103996006 C03317 ZINC28021144 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735281 CSCC[C@H]([NH3+])C(=O)OC[C@H]1O[C@@H](CCn2nnc(n2)-c2ccccc2)[C@H](O)[C@@H]1O InChI=1S/C19H27N5O5S/c1-30-10-8-13(20)19(27)28-11-15-17(26)16(25)14(29-15)7-9-24-22-18(21-23-24)12-5-3-2-4-6-12/h2-6,13-17,25-26H,7-11,20H2,1H3/p+1/t13-,14-,15+,16-,17+/m0/s1 UQJOWFWDQNQXKF-ZOFXXKQRSA-O 50099085 (S)-1-{(2R,3S,4R,5S)-3,4-Dihydroxy-5-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furan-2-ylmethoxycarbonyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens >256000 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099085&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44384823 103996008 C03317 ZINC28014446 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735282 CSCC[C@H]([NH3+])C(=O)OC[C@H]1O[C@@H](CCn2cnc3c(N)ncnc23)[C@H](O)[C@@H]1O InChI=1S/C17H26N6O5S/c1-29-5-3-9(18)17(26)27-6-11-14(25)13(24)10(28-11)2-4-23-8-22-12-15(19)20-7-21-16(12)23/h7-11,13-14,24-25H,2-6,18H2,1H3,(H2,19,20,21)/p+1/t9-,10-,11+,13-,14+/m0/s1 MIAQLAQZBQAFGH-CVNCSBKSSA-O 50099084 (S)-1-{(2R,3S,4R,5S)-5-[2-(6-Amino-purin-9-yl)-ethyl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxycarbonyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 8300 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099084&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44384886 103996007 C03317 ZINC28014899 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735283 CSCC[C@H]([NH3+])C(=O)OC[C@H]1O[C@@H](Cn2cnc3c(N)ncnc23)[C@H](O)[C@@H]1O InChI=1S/C16H24N6O5S/c1-28-3-2-8(17)16(25)26-5-10-13(24)12(23)9(27-10)4-22-7-21-11-14(18)19-6-20-15(11)22/h6-10,12-13,23-24H,2-5,17H2,1H3,(H2,18,19,20)/p+1/t8-,9-,10+,12-,13+/m0/s1 HQXDQVBDUIILNZ-VKISENBKSA-O 50099086 (S)-1-[(2R,3S,4R,5S)-5-(6-Amino-purin-9-ylmethyl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 3600 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099086&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44386345 103996009 C03317 ZINC28110984 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735284 CSCC[C@H]([NH3+])C(=O)N(O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 InChI=1S/C15H23N7O5S/c1-28-3-2-7(16)14(25)22(26)4-8-10(23)11(24)15(27-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,15,23-24,26H,2-4,16H2,1H3,(H2,17,18,19)/p+1/t7-,8+,10+,11+,15+/m0/s1 SYRPSSWOVSULIZ-JVEUSOJLSA-O 50099087 (S)-1-{[(2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-hydroxy-carbamoyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 27000 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099087&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44386009 103996010 ZINC03923717 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735285 CSCC[C@H]([NH3+])C(=O)OC[C@H]1O[C@@H](CCn2cnc3c(NCc4ccccc4)ncnc23)[C@H](O)[C@@H]1O InChI=1S/C24H32N6O5S/c1-36-10-8-16(25)24(33)34-12-18-21(32)20(31)17(35-18)7-9-30-14-29-19-22(27-13-28-23(19)30)26-11-15-5-3-2-4-6-15/h2-6,13-14,16-18,20-21,31-32H,7-12,25H2,1H3,(H,26,27,28)/p+1/t16-,17-,18+,20-,21+/m0/s1 ZJQOYDDJFNTSAP-GCGJSEPQSA-O 50099089 (S)-1-{(2R,3S,4R,5S)-5-[2-(6-Benzylamino-purin-9-yl)-ethyl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxycarbonyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 33200 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099089&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44384772 103996012 C03317 ZINC28007906 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735286 CSCC[C@H]([NH3+])C(=O)N(O)C[C@H]1O[C@@H](Cn2cnc3c(NCc4ccccc4)ncnc23)[C@H](O)[C@@H]1O InChI=1S/C23H31N7O5S/c1-36-8-7-15(24)23(33)30(34)11-17-20(32)19(31)16(35-17)10-29-13-28-18-21(26-12-27-22(18)29)25-9-14-5-3-2-4-6-14/h2-6,12-13,15-17,19-20,31-32,34H,7-11,24H2,1H3,(H,25,26,27)/p+1/t15-,16-,17+,19-,20+/m0/s1 WENOOOPKIRLVMY-VBYALHQYSA-O 50099088 (S)-1-{[(2R,3S,4R,5S)-5-(6-Benzylamino-purin-9-ylmethyl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-hydroxy-carbamoyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 63000 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099088&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385482 103996011 ZINC28022427 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735288 CSCC[C@H]([NH3+])C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 InChI=1S/C15H22N6O5S/c1-27-3-2-7(16)15(24)25-4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2,17,18,19)/p+1/t7-,8+,10+,11+,14+/m0/s1 MUIFRRWPJKQRBG-TWBCTODHSA-O 50099090 (S)-1-[(2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 5000 ChEMBL 10.1016/s0960-894x(01)00095-6 10.7270/Q2NP2507 11327600 Lee, J; Kang, SU; Kim, SY; Kim, SE; Kang, MK; Jo, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099090&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385958 103996013 C03317 ZINC53227596 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735290 COc1cc(CC(=O)N(O)CCOC(=O)[C@@H]([NH3+])CCSC)ccc1O InChI=1S/C16H24N2O6S/c1-23-14-9-11(3-4-13(14)19)10-15(20)18(22)6-7-24-16(21)12(17)5-8-25-2/h3-4,9,12,19,22H,5-8,10,17H2,1-2H3/p+1/t12-/m0/s1 IPDRXAQHRVMBQI-LBPRGKRZSA-O 50099093 (S)-1-(2-{Hydroxy-[2-(4-hydroxy-3-methoxy-phenyl)-acetyl]-amino}-ethoxycarbonyl)-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 128500 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099093&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385137 103996016 C03317 ZINC28013452 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735293 COc1cc(ccc1O)C1=N[C@@H](COC(=O)[C@@H]([NH3+])CCSC)CO1 InChI=1S/C16H22N2O5S/c1-21-14-7-10(3-4-13(14)19)15-18-11(8-22-15)9-23-16(20)12(17)5-6-24-2/h3-4,7,11-12,19H,5-6,8-9,17H2,1-2H3/p+1/t11-,12+/m1/s1 RPXIJXVRWSNMOW-NEPJUHHUSA-O 50099096 (S)-1-[(R)-2-(4-Hydroxy-3-methoxy-phenyl)-4,5-dihydro-oxazol-4-ylmethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 39000 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099096&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385154 103996019 C03317 ZINC28086733 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735299 COc1ccc(cc1O)C(=O)NCCOC(=O)[C@@H]([NH3+])CCSC InChI=1S/C15H22N2O5S/c1-21-13-4-3-10(9-12(13)18)14(19)17-6-7-22-15(20)11(16)5-8-23-2/h3-4,9,11,18H,5-8,16H2,1-2H3,(H,17,19)/p+1/t11-/m0/s1 FLGBOONQDZQMFR-NSHDSACASA-O 50099102 (S)-1-[2-(3-Hydroxy-4-methoxy-benzoylamino)-ethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 78000 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099102&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44384675 103996025 C03317 ZINC28014948 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735300 COc1ccc(cc1O)C1=NOC(COC(=O)[C@@H]([NH3+])CCSC)C1 InChI=1S/C16H22N2O5S/c1-21-15-4-3-10(7-14(15)19)13-8-11(23-18-13)9-22-16(20)12(17)5-6-24-2/h3-4,7,11-12,19H,5-6,8-9,17H2,1-2H3/p+1/t11?,12-/m0/s1 NCDQMASWNLKLCX-KIYNQFGBSA-O 50099103 (S)-1-[3-(3-Hydroxy-4-methoxy-phenyl)-4,5-dihydro-isoxazol-5-ylmethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 47000 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099103&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385302 103996026 C03317 ZINC28091987 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735301 COc1ccc(CC(=O)N(O)CCOC(=O)[C@@H]([NH3+])CCSC)cc1O InChI=1S/C16H24N2O6S/c1-23-14-4-3-11(9-13(14)19)10-15(20)18(22)6-7-24-16(21)12(17)5-8-25-2/h3-4,9,12,19,22H,5-8,10,17H2,1-2H3/p+1/t12-/m0/s1 DWCUDTWQZCNSRE-LBPRGKRZSA-O 50099104 (S)-1-(2-{Hydroxy-[2-(3-hydroxy-4-methoxy-phenyl)-acetyl]-amino}-ethoxycarbonyl)-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 87000 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099104&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44386020 103996027 C03317 ZINC28013400 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735303 COc1cc(CC(=O)NCCOC(=O)[C@@H]([NH3+])CCSC)ccc1O InChI=1S/C16H24N2O5S/c1-22-14-9-11(3-4-13(14)19)10-15(20)18-6-7-23-16(21)12(17)5-8-24-2/h3-4,9,12,19H,5-8,10,17H2,1-2H3,(H,18,20)/p+1/t12-/m0/s1 DWSRIDOONJGVLA-LBPRGKRZSA-O 50099106 (S)-1-{2-[2-(4-Hydroxy-3-methoxy-phenyl)-acetylamino]-ethoxycarbonyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 94000 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099106&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385307 103996029 C03317 ZINC28092011 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735304 COc1cc(ccc1O)C1=N[C@H](COC(=O)[C@@H]([NH3+])CCSC)CO1 InChI=1S/C16H22N2O5S/c1-21-14-7-10(3-4-13(14)19)15-18-11(8-22-15)9-23-16(20)12(17)5-6-24-2/h3-4,7,11-12,19H,5-6,8-9,17H2,1-2H3/p+1/t11-,12-/m0/s1 RPXIJXVRWSNMOW-RYUDHWBXSA-O 50099107 (S)-1-[(S)-2-(4-Hydroxy-3-methoxy-phenyl)-4,5-dihydro-oxazol-4-ylmethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 33500 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099107&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385103 103996030 C03317 ZINC28021993 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735305 COc1cc(ccc1O)C(=O)NCCOC(=O)[C@@H]([NH3+])CCSC InChI=1S/C15H22N2O5S/c1-21-13-9-10(3-4-12(13)18)14(19)17-6-7-22-15(20)11(16)5-8-23-2/h3-4,9,11,18H,5-8,16H2,1-2H3,(H,17,19)/p+1/t11-/m0/s1 DZVDHDMFNGHVPH-NSHDSACASA-O 50099108 (S)-1-[2-(4-Hydroxy-3-methoxy-benzoylamino)-ethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 60000 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099108&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385733 103996031 C03317 ZINC28088544 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735306 COc1cc(ccc1O)C(=O)N(O)CCOC(=O)[C@@H]([NH3+])CCSC InChI=1S/C15H22N2O6S/c1-22-13-9-10(3-4-12(13)18)14(19)17(21)6-7-23-15(20)11(16)5-8-24-2/h3-4,9,11,18,21H,5-8,16H2,1-2H3/p+1/t11-/m0/s1 JUSHWIXTPAMZEA-NSHDSACASA-O 50099111 (S)-1-{2-[Hydroxy-(4-hydroxy-3-methoxy-benzoyl)-amino]-ethoxycarbonyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 32500 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099111&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385737 103996034 C03317 ZINC28095479 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735309 COc1ccc(cc1O)C(=O)N(O)CCOC(=O)[C@@H]([NH3+])CCSC InChI=1S/C15H22N2O6S/c1-22-13-4-3-10(9-12(13)18)14(19)17(21)6-7-23-15(20)11(16)5-8-24-2/h3-4,9,11,18,21H,5-8,16H2,1-2H3/p+1/t11-/m0/s1 NNHQMWBVDRGMQJ-NSHDSACASA-O 50099110 (S)-1-{2-[Hydroxy-(3-hydroxy-4-methoxy-benzoyl)-amino]-ethoxycarbonyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 72000 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099110&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44384558 103996033 C03317 ZINC28007494 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735310 COc1ccc(CC(=O)NCCOC(=O)[C@@H]([NH3+])CCSC)cc1O InChI=1S/C16H24N2O5S/c1-22-14-4-3-11(9-13(14)19)10-15(20)18-6-7-23-16(21)12(17)5-8-24-2/h3-4,9,12,19H,5-8,10,17H2,1-2H3,(H,18,20)/p+1/t12-/m0/s1 SFYIRPVANJCFSN-LBPRGKRZSA-O 50099113 (S)-1-{2-[2-(3-Hydroxy-4-methoxy-phenyl)-acetylamino]-ethoxycarbonyl}-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 163500 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099113&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385051 103996036 C03317 ZINC28008750 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50735311 COc1cc(ccc1O)C1=NOC(COC(=O)[C@@H]([NH3+])CCSC)C1 InChI=1S/C16H22N2O5S/c1-21-15-7-10(3-4-14(15)19)13-8-11(23-18-13)9-22-16(20)12(17)5-6-24-2/h3-4,7,11-12,19H,5-6,8-9,17H2,1-2H3/p+1/t11?,12-/m0/s1 FFMCPVPOFZFSMY-KIYNQFGBSA-O 50099115 (S)-1-[3-(4-Hydroxy-3-methoxy-phenyl)-4,5-dihydro-isoxazol-5-ylmethoxycarbonyl]-3-methylsulfanyl-propyl-ammonium Methionine--tRNA ligase, cytoplasmic Homo sapiens 58000 ChEMBL 10.1016/s0960-894x(01)00096-8 10.7270/Q2HX1D72 11327601 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50099115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50099115&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44385855 103996038 C03317 ZINC28093163 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50740439 CSCC[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)nc(nc12)C#C InChI=1S/C17H23N7O7S2/c1-3-10-21-14(19)11-15(22-10)24(7-20-11)17-13(26)12(25)9(31-17)6-30-33(28,29)23-16(27)8(18)4-5-32-2/h1,7-9,12-13,17,25-26H,4-6,18H2,2H3,(H,23,27)(H2,19,21,22)/t8-,9+,12+,13+,17?/m0/s1 BRUYVQUGDVFQHC-XBOGQWRSSA-N 50366861 CHEMBL605595 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1100 ChEMBL 10.1016/s0960-894x(03)00020-9 10.7270/Q29K4BRS 12643918 Lee, J; Kim, SE; Lee, JY; Kim, SY; Kang, SU; Seo, SH; Chun, MW; Kang, T; Choi, SY; Kim, HO Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366861&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 46874939 160845963 CHEMBL605595 ZINC49114270 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50740441 CCCCC#Cc1nc(N)c2ncn(C3O[C@H](COS(=O)(=O)NC(=O)[C@@H](N)CCSC)[C@@H](O)[C@H]3O)c2n1 InChI=1S/C21H31N7O7S2/c1-3-4-5-6-7-14-25-18(23)15-19(26-14)28(11-24-15)21-17(30)16(29)13(35-21)10-34-37(32,33)27-20(31)12(22)8-9-36-2/h11-13,16-17,21,29-30H,3-5,8-10,22H2,1-2H3,(H,27,31)(H2,23,25,26)/t12-,13+,16+,17+,21?/m0/s1 NHAUWNFNNPFQTH-YKJSEVMDSA-N 50366863 CHEMBL605806 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1900 ChEMBL 10.1016/s0960-894x(03)00020-9 10.7270/Q29K4BRS 12643918 Lee, J; Kim, SE; Lee, JY; Kim, SY; Kang, SU; Seo, SH; Chun, MW; Kang, T; Choi, SY; Kim, HO Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366863&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 46874963 160845965 CHEMBL605806 ZINC49802422 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50740442 CSCC[C@H](N)C(=O)NS(=O)(=O)N(O)C[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 InChI=1S/C15H24N8O7S2/c1-31-3-2-7(16)14(26)21-32(28,29)23(27)4-8-10(24)11(25)15(30-8)22-6-20-9-12(17)18-5-19-13(9)22/h5-8,10-11,15,24-25,27H,2-4,16H2,1H3,(H,21,26)(H2,17,18,19)/t7-,8+,10+,11+,15?/m0/s1 MSGWKMMPRXGVDY-VUTIGSQVSA-N 50366864 CHEMBL605180 Methionine--tRNA ligase, cytoplasmic Homo sapiens 106000 ChEMBL 10.1016/s0960-894x(03)00020-9 10.7270/Q29K4BRS 12643918 Lee, J; Kim, SE; Lee, JY; Kim, SY; Kang, SU; Seo, SH; Chun, MW; Kang, T; Choi, SY; Kim, HO Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366864&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 46874903 160845966 CHEMBL605180 ZINC49114569 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50740444 CSCC[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)nc(Cl)nc12 InChI=1S/C15H22ClN7O7S2/c1-31-3-2-6(17)13(26)22-32(27,28)29-4-7-9(24)10(25)14(30-7)23-5-19-8-11(18)20-15(16)21-12(8)23/h5-7,9-10,14,24-25H,2-4,17H2,1H3,(H,22,26)(H2,18,20,21)/t6-,7+,9+,10+,14?/m0/s1 PONIAOPQSSAZPE-MINKBCJLSA-N 50366866 CHEMBL605812 Methionine--tRNA ligase, cytoplasmic Homo sapiens 7400 ChEMBL 10.1016/s0960-894x(03)00020-9 10.7270/Q29K4BRS 12643918 Lee, J; Kim, SE; Lee, JY; Kim, SY; Kang, SU; Seo, SH; Chun, MW; Kang, T; Choi, SY; Kim, HO Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366866&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 46874969 160845968 CHEMBL605812 ZINC48999127 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50740445 CSCC[C@H](N)C(=O)NS(=O)(=O)NOC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 InChI=1S/C15H24N8O7S2/c1-31-3-2-7(16)14(26)21-32(27,28)22-29-4-8-10(24)11(25)15(30-8)23-6-20-9-12(17)18-5-19-13(9)23/h5-8,10-11,15,22,24-25H,2-4,16H2,1H3,(H,21,26)(H2,17,18,19)/t7-,8+,10+,11+,15?/m0/s1 GFSGGUAIONSFBJ-VUTIGSQVSA-N 50366867 CHEMBL603514 Methionine--tRNA ligase, cytoplasmic Homo sapiens 19700 ChEMBL 10.1016/s0960-894x(03)00020-9 10.7270/Q29K4BRS 12643918 Lee, J; Kim, SE; Lee, JY; Kim, SY; Kang, SU; Seo, SH; Chun, MW; Kang, T; Choi, SY; Kim, HO Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366867&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 46874935 160845969 CHEMBL603514 ZINC48995309 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50740446 CSCC[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)nc(I)nc12 InChI=1S/C15H22IN7O7S2/c1-31-3-2-6(17)13(26)22-32(27,28)29-4-7-9(24)10(25)14(30-7)23-5-19-8-11(18)20-15(16)21-12(8)23/h5-7,9-10,14,24-25H,2-4,17H2,1H3,(H,22,26)(H2,18,20,21)/t6-,7+,9+,10+,14?/m0/s1 FLTXQDUGYDSHQB-MINKBCJLSA-N 50366868 CHEMBL605589 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1200 ChEMBL 10.1016/s0960-894x(03)00020-9 10.7270/Q29K4BRS 12643918 Lee, J; Kim, SE; Lee, JY; Kim, SY; Kang, SU; Seo, SH; Chun, MW; Kang, T; Choi, SY; Kim, HO Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366868&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 46874929 160845970 CHEMBL605589 ZINC49793442 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50740451 CNc1nc(I)nc2n(cnc12)C1O[C@H](COS(=O)(=O)NC(=O)[C@@H](N)CCSC)[C@@H](O)[C@H]1O InChI=1S/C16H24IN7O7S2/c1-19-12-9-13(22-16(17)21-12)24(6-20-9)15-11(26)10(25)8(31-15)5-30-33(28,29)23-14(27)7(18)3-4-32-2/h6-8,10-11,15,25-26H,3-5,18H2,1-2H3,(H,23,27)(H,19,21,22)/t7-,8+,10+,11+,15?/m0/s1 NBDDPEBCWUEYHK-VUTIGSQVSA-N 50366873 CHEMBL605377 Methionine--tRNA ligase, cytoplasmic Homo sapiens 191000 ChEMBL 10.1016/s0960-894x(03)00020-9 10.7270/Q29K4BRS 12643918 Lee, J; Kim, SE; Lee, JY; Kim, SY; Kang, SU; Seo, SH; Chun, MW; Kang, T; Choi, SY; Kim, HO Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50366873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50366873&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 46874909 160845975 CHEMBL605377 ZINC49767690 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020491 Clc1ccc(c(Cl)c1)-c1ccc(cc1)-c1cc(nn1-c1ccccn1)-n1cnnn1 InChI=1S/C21H13Cl2N7/c22-16-8-9-17(18(23)11-16)14-4-6-15(7-5-14)19-12-21(29-13-25-27-28-29)26-30(19)20-3-1-2-10-24-20/h1-13H XSQZDTHEDIJOJK-UHFFFAOYSA-N 50129528 2-[5-(2',4'-Dichloro-biphenyl-4-yl)-3-tetrazol-1-yl-pyrazol-1-yl]-pyridine::CHEMBL308349 Methionine--tRNA ligase, cytoplasmic Homo sapiens 150 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129528&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311501 104021111 CHEMBL308349 ZINC26288967 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50960089 Fc1cccc(NC(=O)NCCCNCc2cc(Cl)cc(Cl)c2)c1 InChI=1S/C17H18Cl2FN3O/c18-13-7-12(8-14(19)9-13)11-21-5-2-6-22-17(24)23-16-4-1-3-15(20)10-16/h1,3-4,7-10,21H,2,5-6,11H2,(H2,22,23,24) OTNNXBAYBHPBLA-UHFFFAOYSA-N 50393793 CHEMBL2159527 Methionine--tRNA ligase, cytoplasmic Homo sapiens 4246 ChEMBL 10.1021/jm300303e 10.7270/Q2SJ1MQH 22720744 Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393793&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 60195183 163342817 CHEMBL2159527 ZINC95579008 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50960090 Clc1cc(Cl)cc(CNCCCNC(=O)Nc2cccs2)c1 InChI=1S/C15H17Cl2N3OS/c16-12-7-11(8-13(17)9-12)10-18-4-2-5-19-15(21)20-14-3-1-6-22-14/h1,3,6-9,18H,2,4-5,10H2,(H2,19,20,21) HFXBOTYGDZHGMS-UHFFFAOYSA-N 50393794 CHEMBL2159537 Methionine--tRNA ligase, cytoplasmic Homo sapiens 3056 ChEMBL 10.1021/jm300303e 10.7270/Q2SJ1MQH 22720744 Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393794&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 60195365 163342818 CHEMBL2159537 ZINC95575592 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50960091 Clc1cc(Cl)cc(CNCCCNC(=O)Nc2ccccc2)c1 InChI=1S/C17H19Cl2N3O/c18-14-9-13(10-15(19)11-14)12-20-7-4-8-21-17(23)22-16-5-2-1-3-6-16/h1-3,5-6,9-11,20H,4,7-8,12H2,(H2,21,22,23) FFIHIYODYIKHMJ-UHFFFAOYSA-N 50393795 CHEMBL2159512 Methionine--tRNA ligase, cytoplasmic Homo sapiens >10000 ChEMBL 10.1021/jm300303e 10.7270/Q2SJ1MQH 22720744 Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393795&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search C13 4MVX 57339424 163342819 CHEMBL2159512 ZINC95572027 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50960092 COc1cc(Cl)cc(CNCCCNC(=O)Nc2ccccc2)c1 InChI=1S/C18H22ClN3O2/c1-24-17-11-14(10-15(19)12-17)13-20-8-5-9-21-18(23)22-16-6-3-2-4-7-16/h2-4,6-7,10-12,20H,5,8-9,13H2,1H3,(H2,21,22,23) UCQXABGZXQUVHG-UHFFFAOYSA-N 50393796 CHEMBL2159513 Methionine--tRNA ligase, cytoplasmic Homo sapiens 8348 ChEMBL 10.1021/jm300303e 10.7270/Q2SJ1MQH 22720744 Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393796&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 415 4MW5,5K0T 60195001 163342820 CHEMBL2159513 ZINC95573697 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50960093 Clc1cc(Cl)cc(CNCCCNC(=O)Nc2ccsc2)c1 InChI=1S/C15H17Cl2N3OS/c16-12-6-11(7-13(17)8-12)9-18-3-1-4-19-15(21)20-14-2-5-22-10-14/h2,5-8,10,18H,1,3-4,9H2,(H2,19,20,21) DGBJLEREWKGWML-UHFFFAOYSA-N 50393797 CHEMBL2159535 Methionine--tRNA ligase, cytoplasmic Homo sapiens 4349 ChEMBL 10.1021/jm300303e 10.7270/Q2SJ1MQH 22720744 Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393797&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 43E 4PY2,4MVW,4MWD 60195274 163342821 CHEMBL2159535 ZINC95580149 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50960094 Oc1ccccc1NC(=O)NCCCNCc1cc(Cl)cc(Cl)c1 InChI=1S/C17H19Cl2N3O2/c18-13-8-12(9-14(19)10-13)11-20-6-3-7-21-17(24)22-15-4-1-2-5-16(15)23/h1-2,4-5,8-10,20,23H,3,6-7,11H2,(H2,21,22,24) ZTLHNGCVRZQIRX-UHFFFAOYSA-N 50393798 CHEMBL2159525 Methionine--tRNA ligase, cytoplasmic Homo sapiens 3720 ChEMBL 10.1021/jm300303e 10.7270/Q2SJ1MQH 22720744 Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393798&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 392 4MW0 60195181 163342822 CHEMBL2159525 ZINC95580654 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50960095 Oc1cccc(NC(=O)NCCCNCc2cc(Cl)cc(Cl)c2)c1 InChI=1S/C17H19Cl2N3O2/c18-13-7-12(8-14(19)9-13)11-20-5-2-6-21-17(24)22-15-3-1-4-16(23)10-15/h1,3-4,7-10,20,23H,2,5-6,11H2,(H2,21,22,24) GNDFIQUTHVHDAI-UHFFFAOYSA-N 50393799 CHEMBL2159526 Methionine--tRNA ligase, cytoplasmic Homo sapiens 5430 ChEMBL 10.1021/jm300303e 10.7270/Q2SJ1MQH 22720744 Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393799&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 387 4MVY 60195182 163342823 CHEMBL2159526 ZINC95580621 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50960096 COc1cc(Cl)cc(CNCCCNC(=O)Nc2ccsc2)c1 InChI=1S/C16H20ClN3O2S/c1-22-15-8-12(7-13(17)9-15)10-18-4-2-5-19-16(21)20-14-3-6-23-11-14/h3,6-9,11,18H,2,4-5,10H2,1H3,(H2,19,20,21) FARFGOOSWAQYQX-UHFFFAOYSA-N 50393800 CHEMBL2159536 Methionine--tRNA ligase, cytoplasmic Homo sapiens 6591 ChEMBL 10.1021/jm300303e 10.7270/Q2SJ1MQH 22720744 Shibata, S; Gillespie, JR; Ranade, RM; Koh, CY; Kim, JE; Laydbak, JU; Zucker, FH; Hol, WG; Verlinde, CL; Buckner, FS; Fan, E University of Washington http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50393800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50393800&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44F 4MW1 60195275 163342824 CHEMBL2159536 ZINC95580635 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020494 Clc1ccc(c(Cl)c1)-c1ccc(cc1)-c1cc(nn1-c1cccnc1)-n1cnnn1 InChI=1S/C21H13Cl2N7/c22-16-7-8-18(19(23)10-16)14-3-5-15(6-4-14)20-11-21(29-13-25-27-28-29)26-30(20)17-2-1-9-24-12-17/h1-13H VIKLLMSXXJAPQB-UHFFFAOYSA-N 50129541 3-[5-(2',4'-Dichloro-biphenyl-4-yl)-3-tetrazol-1-yl-pyrazol-1-yl]-pyridine::CHEMBL72005 Methionine--tRNA ligase, cytoplasmic Homo sapiens 10600 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129541&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311500 104021124 CHEMBL72005 ZINC26288961 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020495 Clc1ccc(c(Cl)c1)-c1ccc(cc1)-c1cc(nn1-c1cccnc1)-n1cnnn1 InChI=1S/C21H13Cl2N7/c22-16-7-8-18(19(23)10-16)14-3-5-15(6-4-14)20-11-21(29-13-25-27-28-29)26-30(20)17-2-1-9-24-12-17/h1-13H VIKLLMSXXJAPQB-UHFFFAOYSA-N 50129541 3-[5-(2',4'-Dichloro-biphenyl-4-yl)-3-tetrazol-1-yl-pyrazol-1-yl]-pyridine::CHEMBL72005 Methionine--tRNA ligase, cytoplasmic Homo sapiens 130 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129541&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311500 104021124 CHEMBL72005 ZINC26288961 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020497 OCCn1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C18H14Cl2N2O3/c19-13-5-6-14(15(20)9-13)11-1-3-12(4-2-11)17-10-16(18(24)25)21-22(17)7-8-23/h1-6,9-10,23H,7-8H2,(H,24,25) LDQUUHYSEIMRAJ-UHFFFAOYSA-N 50129540 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2-hydroxy-ethyl)-1H-pyrazole-3-carboxylic acid::CHEMBL74009 Methionine--tRNA ligase, cytoplasmic Homo sapiens 11400 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129540&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311478 104021123 CHEMBL74009 ZINC13534756 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020499 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1cccc(c1)C(O)=O InChI=1S/C23H14Cl2N2O4/c24-16-8-9-18(19(25)11-16)13-4-6-14(7-5-13)21-12-20(23(30)31)26-27(21)17-3-1-2-15(10-17)22(28)29/h1-12H,(H,28,29)(H,30,31) GWPFSCZOMVLNRB-UHFFFAOYSA-N 50129526 1-(3-Carboxy-phenyl)-5-(2',4'-dichloro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL73462 Methionine--tRNA ligase, cytoplasmic Homo sapiens 6340 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129526&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311649 104021109 CHEMBL73462 ZINC13534737 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020500 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C22H12Cl4N2O2/c23-14-5-7-16(17(25)9-14)12-1-3-13(4-2-12)21-11-19(22(29)30)27-28(21)20-8-6-15(24)10-18(20)26/h1-11H,(H,29,30) GRDGNNDMWJNVER-UHFFFAOYSA-N 50129536 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL70567 Methionine--tRNA ligase, cytoplasmic Homo sapiens 4880 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129536&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311186 104021119 CHEMBL70567 ZINC13534708 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020501 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccccn1 InChI=1S/C21H13Cl2N3O2/c22-15-8-9-16(17(23)11-15)13-4-6-14(7-5-13)19-12-18(21(27)28)25-26(19)20-3-1-2-10-24-20/h1-12H,(H,27,28) WEHXTYFZRAPTMR-UHFFFAOYSA-N 50129546 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-2-yl-1H-pyrazole-3-carboxylic acid::CHEMBL302471 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129546&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10250987 104021129 CHEMBL302471 ZINC13534762 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020503 OC(=O)c1cc(nn1Cc1ccncc1)-c1ccc(cc1)-c1ccc(Cl)cc1Cl InChI=1S/C22H15Cl2N3O2/c23-17-5-6-18(19(24)11-17)15-1-3-16(4-2-15)20-12-21(22(28)29)27(26-20)13-14-7-9-25-10-8-14/h1-12H,13H2,(H,28,29) GPVVPUOBZYOOQV-UHFFFAOYSA-N 50129550 5-(2',4'-Dichloro-biphenyl-4-yl)-2-pyridin-4-ylmethyl-2H-pyrazole-3-carboxylic acid::CHEMBL73305 Methionine--tRNA ligase, cytoplasmic Homo sapiens 17300 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129550 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129550&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311687 104021133 CHEMBL73305 ZINC13534805 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020504 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C22H12Cl4N2O2/c23-14-5-7-16(17(25)9-14)12-1-3-13(4-2-12)21-11-19(22(29)30)27-28(21)20-8-6-15(24)10-18(20)26/h1-11H,(H,29,30) GRDGNNDMWJNVER-UHFFFAOYSA-N 50129536 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL70567 Methionine--tRNA ligase, cytoplasmic Homo sapiens 8990 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129536&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311186 104021119 CHEMBL70567 ZINC13534708 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020505 COc1ccccc1-n1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)-n1cnnn1 InChI=1S/C23H16Cl2N6O/c1-32-22-5-3-2-4-20(22)31-21(13-23(27-31)30-14-26-28-29-30)16-8-6-15(7-9-16)18-11-10-17(24)12-19(18)25/h2-14H,1H3 WTPNTZOWQPAUOJ-UHFFFAOYSA-N 50129539 1-[5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2-methoxy-phenyl)-1H-pyrazol-3-yl]-1H-tetrazole::CHEMBL304562 Methionine--tRNA ligase, cytoplasmic Homo sapiens 530 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129539&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311483 104021122 CHEMBL304562 ZINC26294076 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020506 OC(=O)c1cc(-c2ccc(cc2)-c2cccc(c2)C(O)=O)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C23H14Cl2N2O4/c24-17-8-9-20(18(25)11-17)27-21(12-19(26-27)23(30)31)14-6-4-13(5-7-14)15-2-1-3-16(10-15)22(28)29/h1-12H,(H,28,29)(H,30,31) CUQMPLKRKKPZJB-UHFFFAOYSA-N 50129525 5-(3'-Carboxy-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL306896 Methionine--tRNA ligase, cytoplasmic Homo sapiens 41300 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129525&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311506 104021108 CHEMBL306896 ZINC13534715 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020507 Clc1ccc(c(Cl)c1)-c1ccc(cc1)-c1cc(nn1-c1cccnc1)C(=O)NCc1nnn[nH]1 InChI=1S/C23H16Cl2N8O/c24-16-7-8-18(19(25)10-16)14-3-5-15(6-4-14)21-11-20(23(34)27-13-22-28-31-32-29-22)30-33(21)17-2-1-9-26-12-17/h1-12H,13H2,(H,27,34)(H,28,29,31,32) JPMLNAZNRRYWQE-UHFFFAOYSA-N 50129527 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-yl-1H-pyrazole-3-carboxylic acid (1H-tetrazol-5-ylmethyl)-amide::CHEMBL307342 Methionine--tRNA ligase, cytoplasmic Homo sapiens 130 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129527&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10345487 104021110 CHEMBL307342 ZINC13534774 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020508 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H13Cl2F3N2O3/c24-15-5-10-18(19(25)11-15)13-1-3-14(4-2-13)21-12-20(22(31)32)29-30(21)16-6-8-17(9-7-16)33-23(26,27)28/h1-12H,(H,31,32) BELUHHKXAXFLAR-UHFFFAOYSA-N 50129530 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL72421 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129530&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311661 104021113 CHEMBL72421 ZINC26295049 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020510 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccc(OC(F)(F)F)cc1 InChI=1S/C23H13Cl2F3N2O3/c24-15-5-10-18(19(25)11-15)13-1-3-14(4-2-13)21-12-20(22(31)32)29-30(21)16-6-8-17(9-7-16)33-23(26,27)28/h1-12H,(H,31,32) BELUHHKXAXFLAR-UHFFFAOYSA-N 50129530 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(4-trifluoromethoxy-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL72421 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129530&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311661 104021113 CHEMBL72421 ZINC26295049 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020513 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(F)c(Cl)c2)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C22H12Cl3FN2O2/c23-15-6-8-20(17(25)10-15)28-21(11-19(27-28)22(29)30)13-3-1-12(2-4-13)14-5-7-18(26)16(24)9-14/h1-11H,(H,29,30) SCEUFRHFXREEGO-UHFFFAOYSA-N 50129538 5-(3'-Chloro-4'-fluoro-biphenyl-4-yl)-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL70536 Methionine--tRNA ligase, cytoplasmic Homo sapiens 17200 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129538&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311484 104021121 CHEMBL70536 ZINC13534712 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020514 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(F)cc2)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C22H13Cl2FN2O2/c23-16-7-10-20(18(24)11-16)27-21(12-19(26-27)22(28)29)15-3-1-13(2-4-15)14-5-8-17(25)9-6-14/h1-12H,(H,28,29) CJYADRABSMIPKS-UHFFFAOYSA-N 50129552 1-(2,4-Dichloro-phenyl)-5-(4'-fluoro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL304623 Methionine--tRNA ligase, cytoplasmic Homo sapiens 43200 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129552&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311737 104021135 CHEMBL304623 ZINC13534721 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020515 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(cc2)C(F)(F)F)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C23H13Cl2F3N2O2/c24-17-9-10-20(18(25)11-17)30-21(12-19(29-30)22(31)32)15-3-1-13(2-4-15)14-5-7-16(8-6-14)23(26,27)28/h1-12H,(H,31,32) VISMJIFBVJNJRQ-UHFFFAOYSA-N 50129549 1-(2,4-Dichloro-phenyl)-5-(4'-trifluoromethyl-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL303469 Methionine--tRNA ligase, cytoplasmic Homo sapiens 33500 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129549 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129549&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311507 104021132 CHEMBL303469 ZINC13534718 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020516 OC(=O)c1cc(-c2ccc(cc2)-c2ccccc2)n(n1)-c1ccc(Cl)cc1Cl InChI=1S/C22H14Cl2N2O2/c23-17-10-11-20(18(24)12-17)26-21(13-19(25-26)22(27)28)16-8-6-15(7-9-16)14-4-2-1-3-5-14/h1-13H,(H,27,28) XPIHGXBSMIVTBJ-UHFFFAOYSA-N 50129547 5-Biphenyl-4-yl-1-(2,4-dichloro-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL306353 Methionine--tRNA ligase, cytoplasmic Homo sapiens 44300 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129547 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129547&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311473 104021130 CHEMBL306353 ZINC13534725 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020518 COc1ccccc1-n1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C23H16Cl2N2O3/c1-30-22-5-3-2-4-20(22)27-21(13-19(26-27)23(28)29)15-8-6-14(7-9-15)17-11-10-16(24)12-18(17)25/h2-13H,1H3,(H,28,29) NVPPSSQYDZGMIQ-UHFFFAOYSA-N 50129544 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL307466 Methionine--tRNA ligase, cytoplasmic Homo sapiens 17800 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129544&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311427 104021127 CHEMBL307466 ZINC13534741 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020519 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(Cc2ccncc2)n1 InChI=1S/C22H15Cl2N3O2/c23-17-5-6-18(19(24)11-17)15-1-3-16(4-2-15)21-12-20(22(28)29)26-27(21)13-14-7-9-25-10-8-14/h1-12H,13H2,(H,28,29) BGJWGJFNDKCBQB-UHFFFAOYSA-N 50129553 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-4-ylmethyl-1H-pyrazole-3-carboxylic acid::CHEMBL308309 Methionine--tRNA ligase, cytoplasmic Homo sapiens 26200 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129553&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311523 104021136 CHEMBL308309 ZINC13534793 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50020520 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(Cc2cccnc2)n1 InChI=1S/C22H15Cl2N3O2/c23-17-7-8-18(19(24)10-17)15-3-5-16(6-4-15)21-11-20(22(28)29)26-27(21)13-14-2-1-9-25-12-14/h1-12H,13H2,(H,28,29) DJIZQXACFIGGIL-UHFFFAOYSA-N 50129533 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-ylmethyl-1H-pyrazole-3-carboxylic acid::CHEMBL304618 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129533&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311665 104021116 CHEMBL304618 ZINC13534789 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235663 CCn1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C18H14Cl2N2O2/c1-2-22-17(10-16(21-22)18(23)24)12-5-3-11(4-6-12)14-8-7-13(19)9-15(14)20/h3-10H,2H2,1H3,(H,23,24) YXLFQADORAOUEZ-UHFFFAOYSA-N 50129532 5-(2',4'-Dichloro-biphenyl-4-yl)-1-ethyl-1H-pyrazole-3-carboxylic acid::CHEMBL69993 Methionine--tRNA ligase, cytoplasmic Homo sapiens 46400 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129532&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311410 104021115 CHEMBL69993 ZINC13534753 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235665 OC(=O)c1cc(nn1Cc1ccccn1)-c1ccc(cc1)-c1ccc(Cl)cc1Cl InChI=1S/C22H15Cl2N3O2/c23-16-8-9-18(19(24)11-16)14-4-6-15(7-5-14)20-12-21(22(28)29)27(26-20)13-17-3-1-2-10-25-17/h1-12H,13H2,(H,28,29) BLKMMQBUPKVNSE-UHFFFAOYSA-N 50129542 5-(2',4'-Dichloro-biphenyl-4-yl)-2-pyridin-2-ylmethyl-2H-pyrazole-3-carboxylic acid::CHEMBL72038 Methionine--tRNA ligase, cytoplasmic Homo sapiens 2680 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129542&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311542 104021125 CHEMBL72038 ZINC13534797 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235669 OC(=O)c1cc(nn1Cc1cccnc1)-c1ccc(cc1)-c1ccc(Cl)cc1Cl InChI=1S/C22H15Cl2N3O2/c23-17-7-8-18(19(24)10-17)15-3-5-16(6-4-15)20-11-21(22(28)29)27(26-20)13-14-2-1-9-25-12-14/h1-12H,13H2,(H,28,29) DXUVKUBMVJGOOH-UHFFFAOYSA-N 50129543 5-(2',4'-Dichloro-biphenyl-4-yl)-2-pyridin-3-ylmethyl-2H-pyrazole-3-carboxylic acid::CHEMBL71729 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1090 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129543&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311541 104021126 CHEMBL71729 ZINC13534801 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235683 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccccn1 InChI=1S/C21H13Cl2N3O2/c22-15-8-9-16(17(23)11-15)13-4-6-14(7-5-13)19-12-18(21(27)28)25-26(19)20-3-1-2-10-24-20/h1-12H,(H,27,28) WEHXTYFZRAPTMR-UHFFFAOYSA-N 50129546 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-2-yl-1H-pyrazole-3-carboxylic acid::CHEMBL302471 Methionine--tRNA ligase, cytoplasmic Homo sapiens 630 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129546&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10250987 104021129 CHEMBL302471 ZINC13534762 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235698 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1cccc(c1)C(O)=O InChI=1S/C23H14Cl2N2O4/c24-16-8-9-18(19(25)11-16)13-4-6-14(7-5-13)21-12-20(23(30)31)26-27(21)17-3-1-2-15(10-17)22(28)29/h1-12H,(H,28,29)(H,30,31) GWPFSCZOMVLNRB-UHFFFAOYSA-N 50129526 1-(3-Carboxy-phenyl)-5-(2',4'-dichloro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL73462 Methionine--tRNA ligase, cytoplasmic Homo sapiens 1190 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129526&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311649 104021109 CHEMBL73462 ZINC13534737 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235702 COc1ccc(cc1)-n1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C23H16Cl2N2O3/c1-30-18-9-7-17(8-10-18)27-22(13-21(26-27)23(28)29)15-4-2-14(3-5-15)19-11-6-16(24)12-20(19)25/h2-13H,1H3,(H,28,29) SVPDZVRKFOHCKQ-UHFFFAOYSA-N 50129537 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(4-methoxy-phenyl)-1H-pyrazole-3-carboxylic acid::CHEMBL71745 Methionine--tRNA ligase, cytoplasmic Homo sapiens >100000 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129537&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311426 104021120 CHEMBL71745 ZINC13534746 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235707 OC(=O)CNC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1cccnc1 InChI=1S/C23H16Cl2N4O3/c24-16-7-8-18(19(25)10-16)14-3-5-15(6-4-14)21-11-20(23(32)27-13-22(30)31)28-29(21)17-2-1-9-26-12-17/h1-12H,13H2,(H,27,32)(H,30,31) QHOSDKDHULDMOD-UHFFFAOYSA-N 50129551 CHEMBL74224::{[5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-yl-1H-pyrazole-3-carbonyl]-amino}-acetic acid Methionine--tRNA ligase, cytoplasmic Homo sapiens 300 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129551 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129551&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311707 104021134 CHEMBL74224 ZINC13534771 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235715 OCCn1nc(cc1-c1ccc(cc1)-c1ccc(Cl)cc1Cl)C(O)=O InChI=1S/C18H14Cl2N2O3/c19-13-5-6-14(15(20)9-13)11-1-3-12(4-2-11)17-10-16(18(24)25)21-22(17)7-8-23/h1-6,9-10,23H,7-8H2,(H,24,25) LDQUUHYSEIMRAJ-UHFFFAOYSA-N 50129540 5-(2',4'-Dichloro-biphenyl-4-yl)-1-(2-hydroxy-ethyl)-1H-pyrazole-3-carboxylic acid::CHEMBL74009 Methionine--tRNA ligase, cytoplasmic Homo sapiens 4460 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129540&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311478 104021123 CHEMBL74009 ZINC13534756 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235716 NC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1ccccn1 InChI=1S/C21H14Cl2N4O/c22-15-8-9-16(17(23)11-15)13-4-6-14(7-5-13)19-12-18(21(24)28)26-27(19)20-3-1-2-10-25-20/h1-12H,(H2,24,28) OYCJBDPYEJFYMO-UHFFFAOYSA-N 50129529 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-2-yl-1H-pyrazole-3-carboxylic acid amide::CHEMBL72460 Methionine--tRNA ligase, cytoplasmic Homo sapiens 2950 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129529&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311708 104021112 CHEMBL72460 ZINC13534768 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235720 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(Cc2ccccc2)n1 InChI=1S/C23H16Cl2N2O2/c24-18-10-11-19(20(25)12-18)16-6-8-17(9-7-16)22-13-21(23(28)29)26-27(22)14-15-4-2-1-3-5-15/h1-13H,14H2,(H,28,29) JJTDTEOYDJOFKZ-UHFFFAOYSA-N 50129531 1-Benzyl-5-(2',4'-dichloro-biphenyl-4-yl)-1H-pyrazole-3-carboxylic acid::CHEMBL304044 Methionine--tRNA ligase, cytoplasmic Homo sapiens 29900 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129531&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311425 104021114 CHEMBL304044 ZINC13534749 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50235726 OC(=O)c1cc(-c2ccc(cc2)-c2ccc(Cl)cc2Cl)n(n1)-c1cccnc1 InChI=1S/C21H13Cl2N3O2/c22-15-7-8-17(18(23)10-15)13-3-5-14(6-4-13)20-11-19(21(27)28)25-26(20)16-2-1-9-24-12-16/h1-12H,(H,27,28) XFMAKVCFFOHWFZ-UHFFFAOYSA-N 50129534 5-(2',4'-Dichloro-biphenyl-4-yl)-1-pyridin-3-yl-1H-pyrazole-3-carboxylic acid::CHEMBL307660 Methionine--tRNA ligase, cytoplasmic Homo sapiens 300 ChEMBL 10.1016/s0960-894x(03)00298-1 10.7270/Q24Q7TCM 12798340 Finn, J; Mattia, K; Morytko, M; Ram, S; Yang, Y; Wu, X; Mak, E; Gallant, P; Keith, D Cubist Pharmaceutical Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129534&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44311709 104021117 CHEMBL307660 ZINC13534765 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0 50593484 CSCC[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 InChI=1S/C15H23N7O7S2/c1-30-3-2-7(16)14(25)21-31(26,27)28-4-8-10(23)11(24)15(29-8)22-6-20-9-12(17)18-5-19-13(9)22/h5-8,10-11,15,23-24H,2-4,16H2,1H3,(H,21,25)(H2,17,18,19)/t7-,8+,10+,11+,15+/m0/s1 PBPVXRRYIIRSNJ-JVEUSOJLSA-N 50222901 CHEMBL1163059 Methionine--tRNA ligase, cytoplasmic Homo sapiens 7 ChEMBL 10.1016/s0960-894x(03)00020-9 10.7270/Q29K4BRS 12643918 Lee, J; Kim, SE; Lee, JY; Kim, SY; Kang, SU; Seo, SH; Chun, MW; Kang, T; Choi, SY; Kim, HO Seoul National University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50222901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50002405&target=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50222901&enzyme=Methionine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 447829 377008332 CHEMBL1163059 1 MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK 2DJV,4BL7,5GL7,5GOY Methionine--tRNA ligase, cytoplasmic SYMC_HUMAN P56192 B3KVK7 Q14895 Q53H14 Q96A15 Q96BZ0 Q9NSE0