BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50124180 CS(=O)c1ccc(cc1)-n1[nH]c(c(-c2ccc(F)cc2)c1=O)-c1ccncc1 InChI=1S/C21H16FN3O2S/c1-28(27)18-8-6-17(7-9-18)25-21(26)19(14-2-4-16(22)5-3-14)20(24-25)15-10-12-23-13-11-15/h2-13,24H,1H3 ZRZICPGMBMJHFN-UHFFFAOYSA-N 50071868 4-(4-Fluoro-phenyl)-2-(4-methanesulfinyl-phenyl)-5-pyridin-4-yl-1,2-dihydro-pyrazol-3-one::CHEMBL315863 Mitogen-activated protein kinase 14 Rattus norvegicus 83 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071868&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 11494897 103965578 CHEMBL315863 ZINC26646228 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124182 c1c([nH]c(c1-c1ccncc1)-c1ccncc1)-c1ccccc1 InChI=1S/C20H15N3/c1-2-4-16(5-3-1)19-14-18(15-6-10-21-11-7-15)20(23-19)17-8-12-22-13-9-17/h1-14,23H JAFCYBMYWOYISM-UHFFFAOYSA-N 50071869 4-(5-phenyl-2-pyridin-4-yl-1H-pyrrol-3-yl)pyridine::CHEMBL88538 Mitogen-activated protein kinase 14 Rattus norvegicus 1220 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071869&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323837 103965579 CHEMBL88538 ZINC26637678 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124185 c1c([nH]c(c1-c1ccncc1)-c1ccccn1)-c1ccccc1 InChI=1S/C20H15N3/c1-2-6-16(7-3-1)19-14-17(15-9-12-21-13-10-15)20(23-19)18-8-4-5-11-22-18/h1-14,23H VRWUCDJZISPAQY-UHFFFAOYSA-N 50071870 2-(5-phenyl-3-pyridin-4-yl-1H-pyrrol-2-yl)pyridine::CHEMBL91721 Mitogen-activated protein kinase 14 Rattus norvegicus 2300 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071870&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324168 103965580 CHEMBL91721 ZINC26644344 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124186 O=C(CCN1CCCCC1)Nc1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C29H30N4O/c34-28(15-20-33-18-5-2-6-19-33)31-25-11-9-23(10-12-25)27-21-26(22-13-16-30-17-14-22)29(32-27)24-7-3-1-4-8-24/h1,3-4,7-14,16-17,21,32H,2,5-6,15,18-20H2,(H,31,34) LRORQQTXWGALKE-UHFFFAOYSA-N 50071871 CHEMBL91165::N-[4-(5-Phenyl-4-pyridin-4-yl-1H-pyrrol-2-yl)-phenyl]-3-piperidin-1-yl-propionamide Mitogen-activated protein kinase 14 Rattus norvegicus 390 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071871&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323920 103965581 CHEMBL91165 ZINC03832145 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124188 c1c([nH]c(c1-c1ccncc1)-c1cccnc1)-c1ccccc1 InChI=1S/C20H15N3/c1-2-5-16(6-3-1)19-13-18(15-8-11-21-12-9-15)20(23-19)17-7-4-10-22-14-17/h1-14,23H OJSMHYYZJVCGEW-UHFFFAOYSA-N 50071872 3-(5-phenyl-3-pyridin-4-yl-1H-pyrrol-2-yl)pyridine::CHEMBL327390 Mitogen-activated protein kinase 14 Rattus norvegicus 240 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071872&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324169 103965582 CHEMBL327390 ZINC03832128 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124189 COc1ccc(OC)c(c1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C23H19FN2O2/c1-27-18-7-8-22(28-2)20(13-18)21-14-19(15-9-11-25-12-10-15)23(26-21)16-3-5-17(24)6-4-16/h3-14,26H,1-2H3 OJFUHLOGAMKMDM-UHFFFAOYSA-N 50071874 4-[5-(2,5-Dimethoxy-phenyl)-2-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL329889 Mitogen-activated protein kinase 14 Rattus norvegicus 1700 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071874&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324194 103965584 CHEMBL329889 ZINC26643014 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124190 Fc1ccc(cc1)-c1cc(oc1-c1ccncc1)-c1ccc(Cl)cc1 InChI=1S/C21H13ClFNO/c22-17-5-1-15(2-6-17)20-13-19(14-3-7-18(23)8-4-14)21(25-20)16-9-11-24-12-10-16/h1-13H XMEBUFZUJWSUHD-UHFFFAOYSA-N 50071875 4-(5-(4-chlorophenyl)-3-(4-fluorophenyl)furan-2-yl)pyridine::4-[5-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-furan-2-yl]-pyridine::CHEMBL88925 Mitogen-activated protein kinase 14 Rattus norvegicus 530 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071875&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323871 103965585 CHEMBL88925 ZINC03832163 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124191 CCOC(=O)c1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C24H20N2O2/c1-2-28-24(27)20-10-8-19(9-11-20)23-21(17-12-14-25-15-13-17)16-22(26-23)18-6-4-3-5-7-18/h3-16,26H,2H2,1H3 NRXVRNHRRJNYFV-UHFFFAOYSA-N 50071876 4-(5-Phenyl-3-pyridin-4-yl-1H-pyrrol-2-yl)-benzoic acid ethyl ester::CHEMBL90261 Mitogen-activated protein kinase 14 Rattus norvegicus >10000 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071876&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323886 103965586 CHEMBL90261 ZINC26646354 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124192 Fc1ccccc1-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C21H15FN2/c22-19-9-5-4-8-17(19)20-14-18(15-10-12-23-13-11-15)21(24-20)16-6-2-1-3-7-16/h1-14,24H LCGDEQAHPOXNRB-UHFFFAOYSA-N 50071877 4-[5-(2-Fluoro-phenyl)-2-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL327911 Mitogen-activated protein kinase 14 Rattus norvegicus 34 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071877&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324162 103965587 CHEMBL327911 ZINC03832072 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124194 Clc1ccccc1-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H15ClN2/c22-19-9-5-4-8-17(19)21-18(15-10-12-23-13-11-15)14-20(24-21)16-6-2-1-3-7-16/h1-14,24H HOQZGEIRBTVRNK-UHFFFAOYSA-N 50071878 4-[2-(2-Chloro-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL90341 Mitogen-activated protein kinase 14 Rattus norvegicus 500 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071878&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323866 103965588 CHEMBL90341 ZINC00022123 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124196 c1cc(co1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C19H14N2O/c1-2-4-15(5-3-1)18-12-17(14-6-9-20-10-7-14)19(21-18)16-8-11-22-13-16/h1-13,21H LHXSSNYGSRDXTG-UHFFFAOYSA-N 50071879 4-(2-Furan-3-yl-5-phenyl-1H-pyrrol-3-yl)-pyridine::CHEMBL541213 Mitogen-activated protein kinase 14 Rattus norvegicus 660 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071879&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324117 103965589 CHEMBL541213 ZINC03832170 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124198 Fc1ccc(cc1)-c1[nH]n(-c2ccc(Cl)cc2)c(=O)c1-c1ccncc1 InChI=1S/C20H13ClFN3O/c21-15-3-7-17(8-4-15)25-20(26)18(13-9-11-23-12-10-13)19(24-25)14-1-5-16(22)6-2-14/h1-12,24H PRQWAZOCOMJRCV-UHFFFAOYSA-N 50071880 2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-4-pyridin-4-yl-1,2-dihydro-pyrazol-3-one::CHEMBL330010 Mitogen-activated protein kinase 14 Rattus norvegicus 500 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071880&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324050 103965590 CHEMBL330010 ZINC03832165 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124201 COc1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C22H18N2O/c1-25-19-9-7-17(8-10-19)21-15-20(16-11-13-23-14-12-16)22(24-21)18-5-3-2-4-6-18/h2-15,24H,1H3 AKIUDQXGSMSBFM-UHFFFAOYSA-N 50071881 4-[5-(4-Methoxy-phenyl)-2-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL90373 Mitogen-activated protein kinase 14 Rattus norvegicus 280 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071881&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324083 103965591 CHEMBL90373 ZINC00022119 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124202 FC(F)(F)c1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C22H15F3N2/c23-22(24,25)18-8-6-17(7-9-18)21-19(15-10-12-26-13-11-15)14-20(27-21)16-4-2-1-3-5-16/h1-14,27H JTAPVIPBGIDRDE-UHFFFAOYSA-N 50071883 4-[5-Phenyl-2-(4-trifluoromethyl-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL91376 Mitogen-activated protein kinase 14 Rattus norvegicus 910 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071883&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324061 103965593 CHEMBL91376 ZINC03832177 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124203 O=C(NCCN1CCCCC1)c1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C29H30N4O/c34-29(31-17-20-33-18-5-2-6-19-33)25-11-9-23(10-12-25)27-21-26(22-13-15-30-16-14-22)28(32-27)24-7-3-1-4-8-24/h1,3-4,7-16,21,32H,2,5-6,17-20H2,(H,31,34) WPVPGOVQVGOWCX-UHFFFAOYSA-N 50071882 4-(5-Phenyl-4-pyridin-4-yl-1H-pyrrol-2-yl)-N-(2-piperidin-1-yl-ethyl)-benzamide::CHEMBL90169 Mitogen-activated protein kinase 14 Rattus norvegicus 97 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071882&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323902 103965592 CHEMBL90169 ZINC00841247 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124204 CS(=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccnc2ccccc12 InChI=1S/C26H19FN2OS/c1-31(30)20-12-8-17(9-13-20)25-16-23(26(29-25)18-6-10-19(27)11-7-18)21-14-15-28-24-5-3-2-4-22(21)24/h2-16,29H,1H3 ICGLLKHAGNAOKI-UHFFFAOYSA-N 50071886 4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl)-1H-pyrrol-3-yl]-quinoline::CHEMBL88844 Mitogen-activated protein kinase 14 Rattus norvegicus 114 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071886&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323875 103965596 CHEMBL88844 ZINC03827319 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124205 Fc1ccc(cc1)-c1[nH]c(nc1-c1ccncc1)-c1ccc(Cl)cc1 InChI=1S/C20H13ClFN3/c21-16-5-1-15(2-6-16)20-24-18(13-3-7-17(22)8-4-13)19(25-20)14-9-11-23-12-10-14/h1-12H,(H,24,25) BYRKVDOSQUAVAB-UHFFFAOYSA-N 50071885 4-[2-(4-Chloro-phenyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyridine::CHEMBL314238 Mitogen-activated protein kinase 14 Rattus norvegicus 80 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071885&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44319591 103965595 CHEMBL314238 ZINC08536527 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124206 Fc1ccc(cc1F)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H14F2N2/c22-18-7-6-16(12-19(18)23)21-17(14-8-10-24-11-9-14)13-20(25-21)15-4-2-1-3-5-15/h1-13,25H QJOICFNPLDJOLA-UHFFFAOYSA-N 50071884 4-[2-(3,4-Difluoro-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL91630 Mitogen-activated protein kinase 14 Rattus norvegicus 4.4 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071884&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324026 103965594 CHEMBL91630 ZINC03832040 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124207 Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccc(Cl)cc1 InChI=1S/C21H14ClFN2/c22-17-5-1-15(2-6-17)20-13-19(14-9-11-24-12-10-14)21(25-20)16-3-7-18(23)8-4-16/h1-13,25H MIFKZJHNVONIML-UHFFFAOYSA-N 50071889 4-[5-(4-Chloro-phenyl)-2-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL88325 Mitogen-activated protein kinase 14 Rattus norvegicus 200 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071889&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323635 103965599 CHEMBL88325 ZINC03832126 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124208 Fc1cccc(c1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C21H15FN2/c22-18-8-4-7-17(13-18)20-14-19(15-9-11-23-12-10-15)21(24-20)16-5-2-1-3-6-16/h1-14,24H CSPWYQCJGVUWAJ-UHFFFAOYSA-N 50071888 4-[5-(3-Fluoro-phenyl)-2-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL328318 Mitogen-activated protein kinase 14 Rattus norvegicus 42 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071888&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324209 103965598 CHEMBL328318 ZINC03832075 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124209 COc1ccc(OC)c(c1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C23H20N2O2/c1-26-18-8-9-22(27-2)20(14-18)21-15-19(16-10-12-24-13-11-16)23(25-21)17-6-4-3-5-7-17/h3-15,25H,1-2H3 ABLSFTOIMOWCPH-UHFFFAOYSA-N 50071887 4-[5-(2,5-Dimethoxy-phenyl)-2-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL91331 Mitogen-activated protein kinase 14 Rattus norvegicus 5000 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071887&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324195 103965597 CHEMBL91331 ZINC26638084 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124210 CS(=O)(=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C22H17FN2O2S/c1-28(26,27)19-8-4-16(5-9-19)21-14-20(15-10-12-24-13-11-15)22(25-21)17-2-6-18(23)7-3-17/h2-14,25H,1H3 GFYZFDVAKCDQST-UHFFFAOYSA-N 50071867 4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL316275 Mitogen-activated protein kinase 14 Rattus norvegicus 9.8 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071867&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 9930407 103965577 CHEMBL316275 ZINC03832052 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124211 Clc1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C21H15ClN2/c22-18-8-6-16(7-9-18)20-14-19(15-10-12-23-13-11-15)21(24-20)17-4-2-1-3-5-17/h1-14,24H BFVHDBSZUNMHQP-UHFFFAOYSA-N 50071890 4-[5-(4-Chloro-phenyl)-2-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL328354 Mitogen-activated protein kinase 14 Rattus norvegicus 510 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071890&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323966 103965600 CHEMBL328354 ZINC03832162 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124212 CC(C)(C)Oc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C25H24N2O/c1-25(2,3)28-21-11-9-20(10-12-21)24-22(18-13-15-26-16-14-18)17-23(27-24)19-7-5-4-6-8-19/h4-17,27H,1-3H3 VNEQDSGOQDCCOK-UHFFFAOYSA-N 50071898 4-[2-(4-tert-Butoxy-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL433350 Mitogen-activated protein kinase 14 Rattus norvegicus >1000 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071898&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323849 103965608 CHEMBL433350 ZINC26641751 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124213 Clc1ccc(cc1Cl)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H14Cl2N2/c22-18-7-6-16(12-19(18)23)21-17(14-8-10-24-11-9-14)13-20(25-21)15-4-2-1-3-5-15/h1-13,25H KLIKGXAAXNGCHA-UHFFFAOYSA-N 50071897 4-[2-(3,4-Dichloro-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL314162 Mitogen-activated protein kinase 14 Rattus norvegicus 30 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071897&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324207 103965607 CHEMBL314162 ZINC26580170 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124214 Fc1ccc(cc1)-c1oc(cc1-c1ccncc1)-c1ccc(Cl)cc1 InChI=1S/C21H13ClFNO/c22-17-5-1-15(2-6-17)20-13-19(14-9-11-24-12-10-14)21(25-20)16-3-7-18(23)8-4-16/h1-13H VFUJKZPVGRYZQX-UHFFFAOYSA-N 50071893 4-[5-(4-Chloro-phenyl)-2-(4-fluoro-phenyl)-furan-3-yl]-pyridine::CHEMBL91459 Mitogen-activated protein kinase 14 Rattus norvegicus 630 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071893&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324072 103965603 CHEMBL91459 ZINC03832166 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124215 Clc1cccc(c1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H15ClN2/c22-18-8-4-7-17(13-18)21-19(15-9-11-23-12-10-15)14-20(24-21)16-5-2-1-3-6-16/h1-14,24H WGVJSWSLJQVVLB-UHFFFAOYSA-N 50071891 4-[2-(3-Chloro-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL314731 Mitogen-activated protein kinase 14 Rattus norvegicus 29 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071891&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323867 103965601 CHEMBL314731 ZINC03832067 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124216 N#Cc1cccc(c1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C22H15N3/c23-15-16-5-4-8-19(13-16)22-20(17-9-11-24-12-10-17)14-21(25-22)18-6-2-1-3-7-18/h1-14,25H XSKGHLWBDSIWMP-UHFFFAOYSA-N 50071892 3-(5-Phenyl-3-pyridin-4-yl-1H-pyrrol-2-yl)-benzonitrile::CHEMBL328148 Mitogen-activated protein kinase 14 Rattus norvegicus 53 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071892&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324043 103965602 CHEMBL328148 ZINC03832078 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124218 Fc1ccc(cc1)-c1[nH]c(cc1-c1ccccn1)-c1ccc(Cl)cc1 InChI=1S/C21H14ClFN2/c22-16-8-4-14(5-9-16)20-13-18(19-3-1-2-12-24-19)21(25-20)15-6-10-17(23)11-7-15/h1-13,25H OLEFUWVGCVDUAF-UHFFFAOYSA-N 50071895 2-[5-(4-Chloro-phenyl)-2-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL90252 Mitogen-activated protein kinase 14 Rattus norvegicus >10000 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071895&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323909 103965605 CHEMBL90252 ZINC26647972 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124219 CSc1ccc(cc1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C22H17FN2S/c1-26-19-8-4-16(5-9-19)21-14-20(15-10-12-24-13-11-15)22(25-21)17-2-6-18(23)7-3-17/h2-14,25H,1H3 PZQZQDIIWVHESQ-UHFFFAOYSA-N 50071894 4-[2-(4-Fluoro-phenyl)-5-(4-methylsulfanyl-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL91652 Mitogen-activated protein kinase 14 Rattus norvegicus 44 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071894&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324149 103965604 CHEMBL91652 ZINC00841240 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124221 Cc1cc(ccn1)-c1cc([nH]c1-c1ccc(F)cc1)-c1ccc(cc1)S(C)=O InChI=1S/C23H19FN2OS/c1-15-13-18(11-12-25-15)21-14-22(16-5-9-20(10-6-16)28(2)27)26-23(21)17-3-7-19(24)8-4-17/h3-14,26H,1-2H3 LFVBYBOZGWMFLQ-UHFFFAOYSA-N 50071896 4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl)-1H-pyrrol-3-yl]-2-methyl-pyridine::CHEMBL91934 Mitogen-activated protein kinase 14 Rattus norvegicus 6 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071896&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323885 103965606 CHEMBL91934 ZINC04628818 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124222 CS(=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C22H17FN2OS/c1-27(26)19-8-4-16(5-9-19)21-14-20(15-10-12-24-13-11-15)22(25-21)17-2-6-18(23)7-3-17/h2-14,25H,1H3 IADKHNLYTDEPGD-UHFFFAOYSA-N 50071873 4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL88486 Mitogen-activated protein kinase 14 Rattus norvegicus 5.1 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071873&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 9885993 103965583 CHEMBL88486 ZINC08469196 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124224 [O-][N+](=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C21H15N3O2/c25-24(26)18-8-6-16(7-9-18)20-14-19(15-10-12-22-13-11-15)21(23-20)17-4-2-1-3-5-17/h1-14,23H HKDMFCFZBNJOPS-UHFFFAOYSA-N 50071903 4-[5-(4-Nitro-phenyl)-2-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL312942 Mitogen-activated protein kinase 14 Rattus norvegicus 6.1 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071903&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323914 103965613 CHEMBL312942 ZINC03832045 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124225 CSc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C22H18N2S/c1-25-19-9-7-18(8-10-19)22-20(16-11-13-23-14-12-16)15-21(24-22)17-5-3-2-4-6-17/h2-15,24H,1H3 WHMXPEFILAQQGE-UHFFFAOYSA-N 50071904 4-[2-(4-Methylsulfanyl-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL315192 Mitogen-activated protein kinase 14 Rattus norvegicus 690 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071904&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323864 103965614 CHEMBL315192 ZINC03832172 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124226 Oc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H16N2O/c24-18-8-6-17(7-9-18)21-19(15-10-12-22-13-11-15)14-20(23-21)16-4-2-1-3-5-16/h1-14,23-24H DGBLAQLVJBSWLW-UHFFFAOYSA-N 50071902 4-(5-Phenyl-3-pyridin-4-yl-1H-pyrrol-2-yl)-phenol::CHEMBL91196 Mitogen-activated protein kinase 14 Rattus norvegicus 2400 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071902&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 18939013 103965612 CHEMBL91196 ZINC26580255 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124227 c1csc(c1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C19H14N2S/c1-2-5-15(6-3-1)17-13-16(14-8-10-20-11-9-14)19(21-17)18-7-4-12-22-18/h1-13,21H JUXJUTAJGGOGPY-UHFFFAOYSA-N 50071901 4-(5-Phenyl-2-thiophen-2-yl-1H-pyrrol-3-yl)-pyridine::CHEMBL314761 Mitogen-activated protein kinase 14 Rattus norvegicus 120 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071901&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324151 103965611 CHEMBL314761 ZINC26641044 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124228 Cc1cnccc1-c1cc([nH]c1-c1ccc(F)cc1)-c1ccc(cc1)S(C)=O InChI=1S/C23H19FN2OS/c1-15-14-25-12-11-20(15)21-13-22(16-5-9-19(10-6-16)28(2)27)26-23(21)17-3-7-18(24)8-4-17/h3-14,26H,1-2H3 SMHQOHVZEZCPJK-UHFFFAOYSA-N 50071909 4-[2-(4-Fluoro-phenyl)-5-(4-methanesulfinyl-phenyl)-1H-pyrrol-3-yl]-3-methyl-pyridine::CHEMBL91274 Mitogen-activated protein kinase 14 Rattus norvegicus 260 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071909&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324094 103965619 CHEMBL91274 ZINC04628817 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124229 Fc1ccc(cc1)-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1 InChI=1S/C21H14ClFN2/c22-17-5-1-15(2-6-17)20-13-19(14-3-7-18(23)8-4-14)21(25-20)16-9-11-24-12-10-16/h1-13,25H JIQRYIXFQANSEL-UHFFFAOYSA-N 50071899 4-[5-(4-Chloro-phenyl)-3-(4-fluoro-phenyl)-1H-pyrrol-2-yl]-pyridine::CHEMBL328126 Mitogen-activated protein kinase 14 Rattus norvegicus 1400 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071899&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 12967031 103965609 CHEMBL328126 ZINC26643672 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124230 N#Cc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C22H15N3/c23-15-16-6-8-19(9-7-16)22-20(17-10-12-24-13-11-17)14-21(25-22)18-4-2-1-3-5-18/h1-14,25H HIJHZQHIPSBZTR-UHFFFAOYSA-N 50071900 4-(5-Phenyl-3-pyridin-4-yl-1H-pyrrol-2-yl)-benzonitrile::CHEMBL330292 Mitogen-activated protein kinase 14 Rattus norvegicus 450 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071900&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324060 103965610 CHEMBL330292 ZINC03832157 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124231 Nc1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C21H17N3/c22-18-8-6-16(7-9-18)20-14-19(15-10-12-23-13-11-15)21(24-20)17-4-2-1-3-5-17/h1-14,24H,22H2 XAMIWMNJLLTESP-UHFFFAOYSA-N 50071906 4-(5-Phenyl-4-pyridin-4-yl-1H-pyrrol-2-yl)-phenylamine::CHEMBL89428 Mitogen-activated protein kinase 14 Rattus norvegicus 28 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071906&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323725 103965616 CHEMBL89428 ZINC03832064 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124232 CCOC(=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C24H20N2O2/c1-2-28-24(27)20-10-8-18(9-11-20)22-16-21(17-12-14-25-15-13-17)23(26-22)19-6-4-3-5-7-19/h3-16,26H,2H2,1H3 VETJNHBFETZIMU-UHFFFAOYSA-N 50071905 4-(5-Phenyl-4-pyridin-4-yl-1H-pyrrol-2-yl)-benzoic acid ethyl ester::CHEMBL431216 Mitogen-activated protein kinase 14 Rattus norvegicus 130 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071905&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323946 103965615 CHEMBL431216 ZINC03832116 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124233 Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccc(Br)cc1 InChI=1S/C21H14BrFN2/c22-17-5-1-15(2-6-17)20-13-19(14-9-11-24-12-10-14)21(25-20)16-3-7-18(23)8-4-16/h1-13,25H ZSJMHGGQBBEHDK-UHFFFAOYSA-N 50071908 4-[5-(4-Bromo-phenyl)-2-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL330563 Mitogen-activated protein kinase 14 Rattus norvegicus 100 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071908&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324219 103965618 CHEMBL330563 ZINC03832103 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124234 OC(=O)c1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C22H16N2O2/c25-22(26)18-8-6-16(7-9-18)20-14-19(15-10-12-23-13-11-15)21(24-20)17-4-2-1-3-5-17/h1-14,24H,(H,25,26) FJFIWHKWHJRREW-UHFFFAOYSA-N 50071910 4-(5-Phenyl-4-pyridin-4-yl-1H-pyrrol-2-yl)-benzoic acid::CHEMBL88904 Mitogen-activated protein kinase 14 Rattus norvegicus 14 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071910&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323661 103965620 CHEMBL88904 ZINC03832054 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124236 Fc1ccc(cc1)-c1c([nH]n(-c2ccc(Cl)cc2)c1=O)-c1ccncc1 InChI=1S/C20H13ClFN3O/c21-15-3-7-17(8-4-15)25-20(26)18(13-1-5-16(22)6-2-13)19(24-25)14-9-11-23-12-10-14/h1-12,24H DZFBYHUKZSRPHU-UHFFFAOYSA-N 50071907 2-(4-Chloro-phenyl)-4-(4-fluoro-phenyl)-5-pyridin-4-yl-1,2-dihydro-pyrazol-3-one::CHEMBL91730 Mitogen-activated protein kinase 14 Rattus norvegicus 35 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071907&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 4665 103965617 CHEMBL91730 6013 ZINC03832073 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124239 Fc1ccc(cc1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C21H15FN2/c22-18-8-6-16(7-9-18)20-14-19(15-10-12-23-13-11-15)21(24-20)17-4-2-1-3-5-17/h1-14,24H PCKHVSFIAUCJDO-UHFFFAOYSA-N 50071911 4-[5-(4-Fluoro-phenyl)-2-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL91568 Mitogen-activated protein kinase 14 Rattus norvegicus 17 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071911&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324102 103965621 CHEMBL91568 ZINC03832057 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124240 Clc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H15ClN2/c22-18-8-6-17(7-9-18)21-19(15-10-12-23-13-11-15)14-20(24-21)16-4-2-1-3-5-16/h1-14,24H FPCNIXTXTWQKQO-UHFFFAOYSA-N 50071912 4-[2-(4-Chloro-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL328150 Mitogen-activated protein kinase 14 Rattus norvegicus 18 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071912&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323842 103965622 CHEMBL328150 ZINC03832058 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124241 COc1ccc(cc1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C22H17FN2O/c1-26-19-8-4-16(5-9-19)21-14-20(15-10-12-24-13-11-15)22(25-21)17-2-6-18(23)7-3-17/h2-14,25H,1H3 ZNZIDJUUECFWDP-UHFFFAOYSA-N 50071913 4-[2-(4-Fluoro-phenyl)-5-(4-methoxy-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL92498 Mitogen-activated protein kinase 14 Rattus norvegicus 60 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071913&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324095 103965623 CHEMBL92498 ZINC03832083 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124242 Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncc1)-c1ccccc1 InChI=1S/C21H15FN2/c22-18-8-6-17(7-9-18)21-19(15-10-12-23-13-11-15)14-20(24-21)16-4-2-1-3-5-16/h1-14,24H HECGYLJLTJNLNO-UHFFFAOYSA-N 50071915 4-[2-(4-Fluoro-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL314219 Mitogen-activated protein kinase 14 Rattus norvegicus 12 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071915&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 12142265 103965625 CHEMBL314219 ZINC03832053 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124243 c1c([nH]c(c1-c1ccncc1)-c1ccccc1)-c1ccccc1 InChI=1S/C21H16N2/c1-3-7-17(8-4-1)20-15-19(16-11-13-22-14-12-16)21(23-20)18-9-5-2-6-10-18/h1-15,23H SDPGDHIJNOYTHQ-UHFFFAOYSA-N 50071919 4-(2,5-Diphenyl-1H-pyrrol-3-yl)-pyridine::CHEMBL419128 Mitogen-activated protein kinase 14 Rattus norvegicus 17 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071919&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323634 103965629 CHEMBL419128 ZINC03832056 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124244 Fc1ccc(cc1)-c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 InChI=1S/C21H14F2N2/c22-17-5-1-15(2-6-17)20-13-19(14-9-11-24-12-10-14)21(25-20)16-3-7-18(23)8-4-16/h1-13,25H CSXBVJCIVUUQNW-UHFFFAOYSA-N 50071916 4-[2,5-Bis-(4-fluoro-phenyl)-1H-pyrrol-3-yl]-pyridine::CHEMBL91648 Mitogen-activated protein kinase 14 Rattus norvegicus 60 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071916&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 18939011 103965626 CHEMBL91648 ZINC00006854 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124245 Fc1ccc(cc1)-c1[nH]c(cc1-c1ccncn1)-c1ccccc1 InChI=1S/C20H14FN3/c21-16-8-6-15(7-9-16)20-17(18-10-11-22-13-23-18)12-19(24-20)14-4-2-1-3-5-14/h1-13,24H WFLMMXFGKGJMIA-UHFFFAOYSA-N 50071918 4-[2-(4-Fluoro-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyrimidine::CHEMBL91540 Mitogen-activated protein kinase 14 Rattus norvegicus 710 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071918&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324055 103965628 CHEMBL91540 ZINC26644791 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124246 Fc1ccc(-c2[nH]c(cc2-c2ccncc2)-c2ccccc2)c(F)c1 InChI=1S/C21H14F2N2/c22-16-6-7-17(19(23)12-16)21-18(14-8-10-24-11-9-14)13-20(25-21)15-4-2-1-3-5-15/h1-13,25H QGJRDYNVFPBAJM-UHFFFAOYSA-N 50071914 4-[2-(2,4-Difluoro-phenyl)-5-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL92440 Mitogen-activated protein kinase 14 Rattus norvegicus 29 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071914&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44324019 103965624 CHEMBL92440 ZINC26646138 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4 50124247 [O-][N+](=O)c1cccc(c1)-c1cc(c([nH]1)-c1ccccc1)-c1ccncc1 InChI=1S/C21H15N3O2/c25-24(26)18-8-4-7-17(13-18)20-14-19(15-9-11-22-12-10-15)21(23-20)16-5-2-1-3-6-16/h1-14,23H RGZLDMQEPQXOPS-UHFFFAOYSA-N 50071917 4-[5-(3-Nitro-phenyl)-2-phenyl-1H-pyrrol-3-yl]-pyridine::CHEMBL88546 Mitogen-activated protein kinase 14 Rattus norvegicus 53 ChEMBL 10.1016/s0960-894x(98)00495-8 10.7270/Q27D2T9N 9873604 de Laszlo, SE; Visco, D; Agarwal, L; Chang, L; Chin, J; Croft, G; Forsyth, A; Fletcher, D; Frantz, B; Hacker, C; Hanlon, W; Harper, C; Kostura, M; Li, B; Luell, S; MacCoss, M; Mantlo, N; O'Neill, EA; Orevillo, C; Pang, M; Parsons, J; Rolando, A; Sahly, Y; Sidler, K; O'Keefe, SJ Merck Research Laboratory http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001918&target=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071917&enzyme=Mitogen-activated+protein+kinase+14&column=ki&startPg=0&Increment=50&submit=Search 44323913 103965627 CHEMBL88546 ZINC03832079 1 MSQERPTFYRQELNKTVWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAEPYDQSFESRDFLIDEWKSLTYDEVISFVPPPLDQEEMES 2BAQ,2FSO,2GHL,2GHM,2PUU,3CTQ,3HEC,3HEG,3K3I,5WJJ,6ANL,6M95,6OHD Mitogen-activated protein kinase 14 MK14_RAT P70618 O08594 Q99MG4