BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50143457 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(O)=O)c1ccc(O)c(O)c1 InChI=1S/C17H18N2O6/c18-12(7-9-1-4-11(20)5-2-9)16(23)19-15(17(24)25)10-3-6-13(21)14(22)8-10/h1-6,8,12,15,20-22H,7,18H2,(H,19,23)(H,24,25)/t12-,15-/m0/s1 XRBKGQKWWAETRP-WFASDCNBSA-N 50081835 (S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-(3,4-dihydroxy-phenyl)-acetic acid::CHEMBL318546 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 11000 ChEMBL 10.1016/s0960-894x(99)00488-6 10.7270/Q2F18XX9 10522706 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081835&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 15516236 103981774 CHEMBL318546 C00107 ZINC26726319 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50143458 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(O)=O)c1ccccc1 InChI=1S/C17H18N2O4/c18-14(10-11-6-8-13(20)9-7-11)16(21)19-15(17(22)23)12-4-2-1-3-5-12/h1-9,14-15,20H,10,18H2,(H,19,21)(H,22,23)/t14-,15-/m0/s1 BTMVTZLCTFHEAN-GJZGRUSLSA-N 50081834 (S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-phenyl-acetic acid::CHEMBL98622 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 900 ChEMBL 10.1016/s0960-894x(99)00488-6 10.7270/Q2F18XX9 10522706 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081834&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 15516230 103981773 CHEMBL98622 C00107 ZINC26719994 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50143459 N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(O)=O)c1ccccc1F InChI=1S/C17H17FN2O4/c18-13-4-2-1-3-12(13)15(17(23)24)20-16(22)14(19)9-10-5-7-11(21)8-6-10/h1-8,14-15,21H,9,19H2,(H,20,22)(H,23,24)/t14-,15?/m0/s1 DULPZMDKLICYRF-MLCCFXAWSA-N 50081836 CHEMBL95616::[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-(2-fluoro-phenyl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 7800 ChEMBL 10.1016/s0960-894x(99)00488-6 10.7270/Q2F18XX9 10522706 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081836&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 15516238 103981775 CHEMBL95616 C00107 ZINC26728050 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50143460 COC(=O)C(NC(=O)[C@@H](N)Cc1ccc(O)cc1)c1ccccc1O InChI=1S/C18H20N2O5/c1-25-18(24)16(13-4-2-3-5-15(13)22)20-17(23)14(19)10-11-6-8-12(21)9-7-11/h2-9,14,16,21-22H,10,19H2,1H3,(H,20,23)/t14-,16?/m0/s1 BNVNOCXKNMFFEC-LBAUFKAWSA-N 50081837 CHEMBL99347::[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-(2-hydroxy-phenyl)-acetic acid methyl ester Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 1200 ChEMBL 10.1016/s0960-894x(99)00488-6 10.7270/Q2F18XX9 10522706 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081837&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 15516233 103981776 CHEMBL99347 ZINC26732210 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50143461 N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(O)=O)c1ccc(O)c(O)c1O InChI=1S/C17H18N2O7/c18-11(7-8-1-3-9(20)4-2-8)16(24)19-13(17(25)26)10-5-6-12(21)15(23)14(10)22/h1-6,11,13,20-23H,7,18H2,(H,19,24)(H,25,26)/t11-,13?/m0/s1 HMXPTPKHMLJMAZ-AMGKYWFPSA-N 50081838 CHEMBL318019::[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-(2,3,4-trihydroxy-phenyl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 510 ChEMBL 10.1016/s0960-894x(99)00488-6 10.7270/Q2F18XX9 10522706 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081838&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 15516237 103981777 CHEMBL318019 C00107 ZINC26718231 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50143462 N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(O)=O)c1ccccc1O InChI=1S/C17H18N2O5/c18-13(9-10-5-7-11(20)8-6-10)16(22)19-15(17(23)24)12-3-1-2-4-14(12)21/h1-8,13,15,20-21H,9,18H2,(H,19,22)(H,23,24)/t13-,15?/m0/s1 HMPUMTAWLAVSJV-CFMCSPIPSA-N 50081839 CHEMBL98455::[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-(2-hydroxy-phenyl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 800 ChEMBL 10.1016/s0960-894x(99)00488-6 10.7270/Q2F18XX9 10522706 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081839&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 15516232 103981778 CHEMBL98455 C00107 ZINC26719989 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50143463 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O InChI=1S/C18H20N2O5/c19-15(9-11-1-5-13(21)6-2-11)17(23)20-16(18(24)25)10-12-3-7-14(22)8-4-12/h1-8,15-16,21-22H,9-10,19H2,(H,20,23)(H,24,25)/t15-,16-/m0/s1 JAQGKXUEKGKTKX-HOTGVXAUSA-N 50081840 (S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionic acid::CHEMBL95286::Tyr-Tyr Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 3800 ChEMBL 10.1016/s0960-894x(99)00488-6 10.7270/Q2F18XX9 10522706 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081840&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 70590 103981779 60989 CHEMBL95286 C00107 ZINC02004481 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50143464 N[C@@H](Cc1ccc(O)cc1)C(=O)NC(C(O)=O)c1cccc(O)c1 InChI=1S/C17H18N2O5/c18-14(8-10-4-6-12(20)7-5-10)16(22)19-15(17(23)24)11-2-1-3-13(21)9-11/h1-7,9,14-15,20-21H,8,18H2,(H,19,22)(H,23,24)/t14-,15?/m0/s1 BSPWVUFVYUODEO-MLCCFXAWSA-N 50081841 CHEMBL95581::[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-(3-hydroxy-phenyl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 3400 ChEMBL 10.1016/s0960-894x(99)00488-6 10.7270/Q2F18XX9 10522706 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Janson, C; Mensah, LM; O'Hanlon, PJ; Pope, A; Saldanha, A; Qiu, X SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081841&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 15516234 103981780 CHEMBL95581 C00107 ZINC26725519 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50175464 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O)C(O)=O InChI=1S/C16H23N3O8/c17-9(5-7-1-3-8(20)4-2-7)15(24)18-11(16(25)26)12-14(23)13(22)10(21)6-19(12)27/h1-4,9-14,20-23,27H,5-6,17H2,(H,18,24)(H,25,26)/t9-,10-,11-,12-,13-,14-/m0/s1 WHHIULQWLVQIEP-LHEWDLALSA-N 50091497 (S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid::CHEMBL51499::[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 1.2 ChEMBL 10.1016/s0960-894x(01)00039-7 10.7270/Q2445KR1 11266175 Brown, P; Eggleston, DS; Haltiwanger, RC; Jarvest, RL; Mensah, L; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091497&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10340034 103989756 CHEMBL51499 C00107 ZINC29481139 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50175465 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@@H]1OC[C@H](O)[C@H](O)[C@H]1O)C(O)=O InChI=1S/C16H22N2O8/c17-9(5-7-1-3-8(19)4-2-7)15(23)18-11(16(24)25)14-13(22)12(21)10(20)6-26-14/h1-4,9-14,19-22H,5-6,17H2,(H,18,23)(H,24,25)/t9-,10-,11-,12-,13+,14-/m0/s1 BMLUBZPHAMWTMM-VZKILSJISA-N 50097744 (S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3R,4S,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-acetic acid::CHEMBL422362::[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3R,4S,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 100 ChEMBL 10.1016/s0960-894x(01)00039-7 10.7270/Q2445KR1 11266175 Brown, P; Eggleston, DS; Haltiwanger, RC; Jarvest, RL; Mensah, L; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097744&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44375544 103994921 CHEMBL422362 C00107 ZINC27754547 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50175466 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]([C@@H]1OC[C@H](O)[C@H](O)[C@H]1O)C(O)=O InChI=1S/C16H22N2O8/c17-9(5-7-1-3-8(19)4-2-7)15(23)18-11(16(24)25)14-13(22)12(21)10(20)6-26-14/h1-4,9-14,19-22H,5-6,17H2,(H,18,23)(H,24,25)/t9-,10-,11+,12-,13+,14-/m0/s1 BMLUBZPHAMWTMM-VPCRRHSYSA-N 50097745 CHEMBL159436::[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3R,4S,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 260 ChEMBL 10.1016/s0960-894x(01)00039-7 10.7270/Q2445KR1 11266175 Brown, P; Eggleston, DS; Haltiwanger, RC; Jarvest, RL; Mensah, L; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097745&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44375543 103994922 CHEMBL159436 C00107 ZINC27752463 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50175467 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C1C(O)[C@]2(O)CO[C@H]([C@H]2O)N1O)C(O)=O InChI=1S/C17H23N3O9/c18-9(5-7-1-3-8(21)4-2-7)14(24)19-10(16(25)26)11-12(22)17(27)6-29-15(13(17)23)20(11)28/h1-4,9-13,15,21-23,27-28H,5-6,18H2,(H,19,24)(H,25,26)/t9-,10-,11?,12?,13+,15+,17+/m0/s1 JOBDOAKLPNMGKV-HBKCPIRDSA-N 50097746 (S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((1R,5R,8S)-2,4,5,8-tetrahydroxy-7-oxa-2-aza-bicyclo[3.2.1]oct-3-yl)-acetic acid::CHEMBL161302 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 2 ChEMBL 10.1016/s0960-894x(01)00039-7 10.7270/Q2445KR1 11266175 Brown, P; Eggleston, DS; Haltiwanger, RC; Jarvest, RL; Mensah, L; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097746&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44375526 103994923 CHEMBL161302 C00107 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50175468 C[C@H]1O[C@@H]([C@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O)[C@H](O)[C@@H](O)[C@H]1O InChI=1S/C17H24N2O8/c1-7-12(21)13(22)14(23)15(27-7)11(17(25)26)19-16(24)10(18)6-8-2-4-9(20)5-3-8/h2-5,7,10-15,20-23H,6,18H2,1H3,(H,19,24)(H,25,26)/t7-,10+,11+,12+,13+,14-,15+/m1/s1 KUCHJUZRDGYEDY-HRNUQJICSA-N 18132 (2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]acetic acid::CHEMBL163022::SB-284485 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 4 ChEMBL 10.1016/S0960-894X(01)00040-3 10.7270/Q20C4V1Q 11266176 Jarvest, RL; Berge, JM; Brown, P; Hamprecht, DW; McNair, DJ; Mensah, L; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18132&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 485 1JIL 446500 46518242 CHEMBL163022 C00107 ZINC06488790 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50175469 N[C@@H](Cc1ccc(O)cc1)C(=O)NC([C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)C(O)=O InChI=1S/C17H24N2O9/c18-9(5-7-1-3-8(21)4-2-7)16(25)19-11(17(26)27)15-14(24)13(23)12(22)10(6-20)28-15/h1-4,9-15,20-24H,5-6,18H2,(H,19,25)(H,26,27)/t9-,10+,11?,12-,13-,14+,15-/m0/s1 QMDZPOJZRZEFED-YFVZCRMOSA-N 50097747 CHEMBL162552::[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 190 ChEMBL 10.1016/S0960-894X(01)00040-3 10.7270/Q20C4V1Q 11266176 Jarvest, RL; Berge, JM; Brown, P; Hamprecht, DW; McNair, DJ; Mensah, L; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097747&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44375858 103994924 CHEMBL162552 C00107 ZINC27846975 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50175470 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@@H]1OC[C@H](O)[C@H](O)[C@H]1O)C(O)=O InChI=1S/C16H22N2O8/c17-9(5-7-1-3-8(19)4-2-7)15(23)18-11(16(24)25)14-13(22)12(21)10(20)6-26-14/h1-4,9-14,19-22H,5-6,17H2,(H,18,23)(H,24,25)/t9-,10-,11-,12-,13+,14-/m0/s1 BMLUBZPHAMWTMM-VZKILSJISA-N 50097744 (S)-[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3R,4S,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-acetic acid::CHEMBL422362::[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3R,4S,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 100 ChEMBL 10.1016/S0960-894X(01)00040-3 10.7270/Q20C4V1Q 11266176 Jarvest, RL; Berge, JM; Brown, P; Hamprecht, DW; McNair, DJ; Mensah, L; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097744&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44375544 103994921 CHEMBL422362 C00107 ZINC27754547 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50175471 CCCCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1O[C@H](C)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C21H32N2O8/c1-3-4-9-30-21(29)15(19-18(27)17(26)16(25)11(2)31-19)23-20(28)14(22)10-12-5-7-13(24)8-6-12/h5-8,11,14-19,24-27H,3-4,9-10,22H2,1-2H3,(H,23,28)/t11-,14+,15+,16+,17+,18-,19+/m1/s1 MTLWINFICPUJFQ-DQTLNXAHSA-N 50097749 CHEMBL163375::[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yl)-acetic acid (S)-butyl ester Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 0.800000 ChEMBL 10.1016/S0960-894X(01)00040-3 10.7270/Q20C4V1Q 11266176 Jarvest, RL; Berge, JM; Brown, P; Hamprecht, DW; McNair, DJ; Mensah, L; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097749&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44375859 103994926 CHEMBL163375 ZINC27844358 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50175472 CCCCOC(=O)C(NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@H]1C[C@@H](O)[C@@H](O)[C@@H](C)O1 InChI=1S/C21H32N2O7/c1-3-4-9-29-21(28)18(17-11-16(25)19(26)12(2)30-17)23-20(27)15(22)10-13-5-7-14(24)8-6-13/h5-8,12,15-19,24-26H,3-4,9-11,22H2,1-2H3,(H,23,27)/t12-,15+,16-,17-,18?,19+/m1/s1 IWLXLRSOEBDZMQ-HJYBWVNFSA-N 50097748 CHEMBL351127::[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2R,4R,5R,6R)-4,5-dihydroxy-6-methyl-tetrahydro-pyran-2-yl)-acetic acid butyl ester Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 3.6 ChEMBL 10.1016/S0960-894X(01)00040-3 10.7270/Q20C4V1Q 11266176 Jarvest, RL; Berge, JM; Brown, P; Hamprecht, DW; McNair, DJ; Mensah, L; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097748&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44375610 103994925 CHEMBL351127 ZINC27764724 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50188734 CCOC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1C=C[C@H](O)[C@H](O)[C@H]1O InChI=1S/C19H26N2O7/c1-2-28-19(27)15(12-7-8-14(23)17(25)16(12)24)21-18(26)13(20)9-10-3-5-11(22)6-4-10/h3-8,12-17,22-25H,2,9,20H2,1H3,(H,21,26)/t12-,13-,14-,15+,16-,17-/m0/s1 VMTUVKNXDKTJOR-LTAJLKHCSA-N 50104310 (R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((1S,4S,5S,6S)-4,5,6-trihydroxy-cyclohex-2-enyl)-acetic acid ethyl ester::CHEMBL82579 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 124 ChEMBL 10.1016/s0960-894x(01)00475-9 10.7270/Q2Z89BPK 11549455 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Mensah, LM; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104310&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10385946 104000256 CHEMBL82579 ZINC26505851 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50188735 CCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1C=C[C@H](O)[C@H](O)[C@H]1O InChI=1S/C19H26N2O7/c1-2-28-19(27)15(12-7-8-14(23)17(25)16(12)24)21-18(26)13(20)9-10-3-5-11(22)6-4-10/h3-8,12-17,22-25H,2,9,20H2,1H3,(H,21,26)/t12-,13-,14-,15-,16-,17-/m0/s1 VMTUVKNXDKTJOR-UYLCUJDWSA-N 50104311 (S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((1S,4S,5S,6S)-4,5,6-trihydroxy-cyclohex-2-enyl)-acetic acid ethyl ester::CHEMBL84867 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 3.4 ChEMBL 10.1016/s0960-894x(01)00475-9 10.7270/Q2Z89BPK 11549455 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Mensah, LM; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104311&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10000708 104000257 CHEMBL84867 ZINC26508276 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50188736 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@H]1[C@H](O)[C@]2(O)CO[C@@H]([C@@H]2O)N1O)C(O)=O InChI=1S/C17H23N3O9/c18-9(5-7-1-3-8(21)4-2-7)14(24)19-10(16(25)26)11-12(22)17(27)6-29-15(13(17)23)20(11)28/h1-4,9-13,15,21-23,27-28H,5-6,18H2,(H,19,24)(H,25,26)/t9-,10-,11-,12-,13-,15-,17+/m0/s1 JOBDOAKLPNMGKV-OEUXZGCXSA-N 18128 (2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-2-[(1S,3S,4S,5R,8R)-2,4,5,8-tetrahydroxy-7-oxa-2-azabicyclo[3.2.1]octan-3-yl]acetic acid::CHEMBL310012::SB-219383 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 0.600000 ChEMBL 10.1016/s0960-894x(01)00475-9 10.7270/Q2Z89BPK 11549455 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Mensah, LM; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18128&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 383 1JII 446497 46518239 CHEMBL310012 C00107 ZINC14967086 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50188737 COC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C1CCCCC1 InChI=1S/C18H26N2O4/c1-24-18(23)16(13-5-3-2-4-6-13)20-17(22)15(19)11-12-7-9-14(21)10-8-12/h7-10,13,15-16,21H,2-6,11,19H2,1H3,(H,20,22)/t15-,16-/m0/s1 NFMPCWZITVVQKV-HOTGVXAUSA-N 50104314 (S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-cyclohexyl-acetic acid methyl ester::CHEMBL309467 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens >3000 ChEMBL 10.1016/s0960-894x(01)00475-9 10.7270/Q2Z89BPK 11549455 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Mensah, LM; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104314&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44318213 104000260 CHEMBL309467 ZINC26507852 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50188738 CCOC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1CC[C@H](O)[C@H](O)[C@H]1O InChI=1S/C19H28N2O7/c1-2-28-19(27)15(12-7-8-14(23)17(25)16(12)24)21-18(26)13(20)9-10-3-5-11(22)6-4-10/h3-6,12-17,22-25H,2,7-9,20H2,1H3,(H,21,26)/t12-,13-,14-,15+,16-,17-/m0/s1 YXNZUCUBFADYBS-LTAJLKHCSA-N 50104312 (R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((1S,2S,3S,4S)-2,3,4-trihydroxy-cyclohexyl)-acetic acid ethyl ester::CHEMBL84569 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens >3000 ChEMBL 10.1016/s0960-894x(01)00475-9 10.7270/Q2Z89BPK 11549455 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Mensah, LM; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104312&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44318202 104000258 CHEMBL84569 ZINC26566533 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50188739 CCOC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H]1CC[C@H](O)[C@H](O)[C@H]1O InChI=1S/C19H28N2O7/c1-2-28-19(27)15(12-7-8-14(23)17(25)16(12)24)21-18(26)13(20)9-10-3-5-11(22)6-4-10/h3-6,12-17,22-25H,2,7-9,20H2,1H3,(H,21,26)/t12-,13-,14-,15-,16-,17-/m0/s1 YXNZUCUBFADYBS-UYLCUJDWSA-N 50104313 (S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((1S,2S,3S,4S)-2,3,4-trihydroxy-cyclohexyl)-acetic acid ethyl ester::CHEMBL85201 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 245 ChEMBL 10.1016/s0960-894x(01)00475-9 10.7270/Q2Z89BPK 11549455 Jarvest, RL; Berge, JM; Houge-Frydrych, CS; Mensah, LM; O'Hanlon, PJ; Pope, AJ GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104313&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44318201 104000259 CHEMBL85201 ZINC26566529 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50730900 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]([C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O)C(O)=O InChI=1S/C16H23N3O8/c17-9(5-7-1-3-8(20)4-2-7)15(24)18-11(16(25)26)12-14(23)13(22)10(21)6-19(12)27/h1-4,9-14,20-23,27H,5-6,17H2,(H,18,24)(H,25,26)/t9-,10-,11+,12-,13-,14-/m0/s1 WHHIULQWLVQIEP-XQZGEAEESA-N 50091496 (R)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid::CHEMBL52779 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 21 ChEMBL 10.1016/s0960-894x(00)00348-6 10.7270/Q23F4Q5G 10969974 Berge, JM; Copley, RC; Eggleston, DS; Hamprecht, DW; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091496&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 13006413 103989755 CHEMBL52779 C00107 ZINC29487614 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50730901 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@H]1[C@H](O)[C@@H](O)[C@@H](O)CN1O)C(O)=O InChI=1S/C16H23N3O8/c17-9(5-7-1-3-8(20)4-2-7)15(24)18-11(16(25)26)12-14(23)13(22)10(21)6-19(12)27/h1-4,9-14,20-23,27H,5-6,17H2,(H,18,24)(H,25,26)/t9-,10-,11-,12-,13-,14-/m0/s1 WHHIULQWLVQIEP-LHEWDLALSA-N 50091497 (S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid::CHEMBL51499::[2-Amino-3-((S)-4-hydroxy-phenyl)-propionylamino]-((2S,3S,4S,5S)-1,3,4,5-tetrahydroxy-piperidin-2-yl)-acetic acid Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 1.2 ChEMBL 10.1016/s0960-894x(00)00348-6 10.7270/Q23F4Q5G 10969974 Berge, JM; Copley, RC; Eggleston, DS; Hamprecht, DW; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50091497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50091497&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 10340034 103989756 CHEMBL51499 C00107 ZINC29481139 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50730903 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@H]1[C@H](O)[C@]2(O)CO[C@@H]([C@@H]2O)N1O)C(O)=O InChI=1S/C17H23N3O9/c18-9(5-7-1-3-8(21)4-2-7)14(24)19-10(16(25)26)11-12(22)17(27)6-29-15(13(17)23)20(11)28/h1-4,9-13,15,21-23,27-28H,5-6,18H2,(H,19,24)(H,25,26)/t9-,10-,11-,12-,13-,15-,17+/m0/s1 JOBDOAKLPNMGKV-OEUXZGCXSA-N 18128 (2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-2-[(1S,3S,4S,5R,8R)-2,4,5,8-tetrahydroxy-7-oxa-2-azabicyclo[3.2.1]octan-3-yl]acetic acid::CHEMBL310012::SB-219383 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 1.4 ChEMBL 10.1016/s0960-894x(00)00348-6 10.7270/Q23F4Q5G 10969974 Berge, JM; Copley, RC; Eggleston, DS; Hamprecht, DW; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18128&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 383 1JII 446497 46518239 CHEMBL310012 C00107 ZINC14967086 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50726512 COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+ YKPUWZUDDOIDPM-SOFGYWHQSA-N 20461 (6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide::(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide::CAP::CHEMBL294199::Capsaicin::Zostrix Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 42000 ChEMBL 10.1016/S0960-894X(97)00434-4 10.7270/Q2CN74D8 Desjardins, M; Desgagnes, J; Lacoste, L; Yang, F; Morin, M; Lapointe, J; Chenevert, R TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=20461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=20461&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 4DY 7LR0,7LPD,7LPB,7VEK,2N27,7LPE,7LPA 1548943 49688535 3374 CHEMBL294199 DB05318 2486 C06866 ZINC01530575 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1 50012376 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@H]1[C@H](O)[C@]2(O)CO[C@@H]([C@@H]2O)N1O)C(O)=O InChI=1S/C17H23N3O9/c18-9(5-7-1-3-8(21)4-2-7)14(24)19-10(16(25)26)11-12(22)17(27)6-29-15(13(17)23)20(11)28/h1-4,9-13,15,21-23,27-28H,5-6,18H2,(H,19,24)(H,25,26)/t9-,10-,11-,12-,13-,15-,17+/m0/s1 JOBDOAKLPNMGKV-OEUXZGCXSA-N 18128 (2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-2-[(1S,3S,4S,5R,8R)-2,4,5,8-tetrahydroxy-7-oxa-2-azabicyclo[3.2.1]octan-3-yl]acetic acid::CHEMBL310012::SB-219383 Tyrosine--tRNA ligase, cytoplasmic Homo sapiens 22000 ChEMBL 10.1016/s0960-894x(00)00348-6 10.7270/Q23F4Q5G 10969974 Berge, JM; Copley, RC; Eggleston, DS; Hamprecht, DW; Jarvest, RL; Mensah, LM; O'Hanlon, PJ; Pope, AJ SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001531&target=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18128&enzyme=Tyrosine--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 383 1JII 446497 46518239 CHEMBL310012 C00107 ZINC14967086 1 MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS 1N3L,1NTG,1Q11,4Q93,4QBT,5THL,7ROU Tyrosine--tRNA ligase, cytoplasmic SYYC_HUMAN P54577 B3KWK4 D3DPQ4 O43276 Q53EN1