BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50412824 COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1 InChI=1S/C18H30N4O4/c1-18(2,3)11-13(23)19-14-15(25-5)20-17(21-16(14)26-6)22-9-7-12(24-4)8-10-22/h12H,7-11H2,1-6H3,(H,19,23) XHJMCIALHJMEBB-UHFFFAOYSA-N 50121051 CHEMBL3621437 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 625 ChEMBL 10.1016/j.bmcl.2015.04.074 10.7270/Q28054FG 25987375 Davoren, JE; Claffey, MM; Snow, SL; Reese, MR; Arora, G; Butler, CR; Boscoe, BP; Chenard, L; DeNinno, SL; Drozda, SE; Duplantier, AJ; Moine, L; Rogers, BN; Rong, S; Schuyten, K; Wright, AS; Zhang, L; Serpa, KA; Weber, ML; Stolyar, P; Whisman, TL; Baker, K; Tse, K; Clark, AJ; Rong, H; Mather, RJ; Lowe, JA Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121051&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 66653331 104013968 CHEMBL3621437 ZINC13860569 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 50952462 COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 InChI=1S/C23H25N3O4S2/c1-16-6-12-19(13-7-16)32(28,29)26-14-4-3-5-21(26)22(27)25-23-24-20(15-31-23)17-8-10-18(30-2)11-9-17/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1 OXQNLLVUVDAEHC-OAQYLSRUSA-N 50390916 CHEMBL2070953 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens >30000 ChEMBL 10.1016/j.bmcl.2012.07.060 10.7270/Q25T3MKN 22910039 Mattmann, ME; Yu, H; Lin, Z; Xu, K; Huang, X; Long, S; Wu, M; McManus, OB; Engers, DW; Le, UM; Li, M; Lindsley, CW; Hopkins, CR Vanderbilt University Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50390916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50390916&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search I0S 7TCI,7XNN,7XNL,7XNK 53347902 160869999 CHEMBL2070953 ZINC84712890 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 50964494 CC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1 InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1 FROGGFONBYACJB-KRWDZBQOSA-N 50395464 CHEMBL2164048 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 200 ChEMBL 10.1021/jm300700v 10.7270/Q2KD2017 22793372 Cheung, YY; Yu, H; Xu, K; Zou, B; Wu, M; McManus, OB; Li, M; Lindsley, CW; Hopkins, CR Vanderbilt University Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50395464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50395464&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 26873419 163344488 CHEMBL2164048 ZINC15941024 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51045156 COc1ccc(Cl)cc1[C@]1(F)C(=O)Nc2cc(ccc12)C(F)(F)F InChI=1S/C16H10ClF4NO2/c1-24-13-5-3-9(17)7-11(13)15(18)10-4-2-8(16(19,20)21)6-12(10)22-14(15)23/h2-7H,1H3,(H,22,23)/t15-/m0/s1 ULYONBAOIMCNEH-HNNXBMFYSA-N 50426567 BMS-204352::FLINDOKALNER::MaxiPost Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 2400 ChEMBL 10.1021/jm3011433 10.7270/Q23B61GZ 23121096 Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50426567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50426567&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 214350 164155442 ZINC00839816 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51135767 C[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1ccccc1 InChI=1S/C21H23F2NO/c1-15(16-8-4-2-5-9-16)24-20(25)19-14-21(22,23)13-12-18(19)17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,24,25)/t15-,18+,19-/m0/s1 CZZMLALOKXNFIA-IPELMVKDSA-N 50465778 CHEMBL4287478 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 4000 ChEMBL 10.1016/j.bmcl.2018.09.036 10.7270/Q28W3H0D 30327146 Seefeld, MA; Lin, H; Holenz, J; Downie, D; Donovan, B; Fu, T; Pasikanti, K; Zhen, W; Cato, M; Chaudhary, KW; Brady, P; Bakshi, T; Morrow, D; Rajagopal, S; Samanta, SK; Madhyastha, N; Kuppusamy, BM; Dougherty, RW; Bhamidipati, R; Mohd, Z; Higgins, GA; Chapman, M; Rouget, C; Lluel, P; Matsuoka, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50465778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50465778&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 145990268 433933043 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51135768 Fc1ccc(cc1F)C(=O)Nc1ccc(Cl)nc1 InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18) GDGUOCFTHNGPBK-UHFFFAOYSA-N 50420049 CHEMBL402146 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.09.036 10.7270/Q28W3H0D 30327146 Seefeld, MA; Lin, H; Holenz, J; Downie, D; Donovan, B; Fu, T; Pasikanti, K; Zhen, W; Cato, M; Chaudhary, KW; Brady, P; Bakshi, T; Morrow, D; Rajagopal, S; Samanta, SK; Madhyastha, N; Kuppusamy, BM; Dougherty, RW; Bhamidipati, R; Mohd, Z; Higgins, GA; Chapman, M; Rouget, C; Lluel, P; Matsuoka, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50420049 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50420049&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 9903497 163369073 CHEMBL402146 ZINC13986802 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51135769 Cc1cc(C)c(NC(=O)C2CC3CCC2C3)c(C)c1 InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19) SIQGKPGBLYKQBB-UHFFFAOYSA-N 50465775 CHEMBL1703636 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 1600 ChEMBL 10.1016/j.bmcl.2018.09.036 10.7270/Q28W3H0D 30327146 Seefeld, MA; Lin, H; Holenz, J; Downie, D; Donovan, B; Fu, T; Pasikanti, K; Zhen, W; Cato, M; Chaudhary, KW; Brady, P; Bakshi, T; Morrow, D; Rajagopal, S; Samanta, SK; Madhyastha, N; Kuppusamy, BM; Dougherty, RW; Bhamidipati, R; Mohd, Z; Higgins, GA; Chapman, M; Rouget, C; Lluel, P; Matsuoka, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50465775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50465775&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 7YV 7VNP,7VNR,7VNQ 3111211 433933040 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51135770 CS(=O)(=O)c1cccc(c1)[C@H](CO)NC(=O)c1cc(ccc1Oc1ccccc1)S(F)(F)(F)(F)F InChI=1S/C22H20F5NO5S2/c1-34(31,32)17-9-5-6-15(12-17)20(14-29)28-22(30)19-13-18(35(23,24,25,26)27)10-11-21(19)33-16-7-3-2-4-8-16/h2-13,20,29H,14H2,1H3,(H,28,30)/t20-/m0/s1 NVODCWXWVPXEIC-FQEVSTJZSA-N 50465779 CHEMBL4278049 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens >10000 ChEMBL 10.1016/j.bmcl.2018.09.036 10.7270/Q28W3H0D 30327146 Seefeld, MA; Lin, H; Holenz, J; Downie, D; Donovan, B; Fu, T; Pasikanti, K; Zhen, W; Cato, M; Chaudhary, KW; Brady, P; Bakshi, T; Morrow, D; Rajagopal, S; Samanta, SK; Madhyastha, N; Kuppusamy, BM; Dougherty, RW; Bhamidipati, R; Mohd, Z; Higgins, GA; Chapman, M; Rouget, C; Lluel, P; Matsuoka, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50465779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50465779&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 145981605 433933044 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51135772 OC[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1cccc(c1)C(F)(F)F InChI=1S/C22H22F5NO2/c23-21(24)10-9-17(14-5-2-1-3-6-14)18(12-21)20(30)28-19(13-29)15-7-4-8-16(11-15)22(25,26)27/h1-8,11,17-19,29H,9-10,12-13H2,(H,28,30)/t17-,18+,19+/m1/s1 RYRYLLQXWGDEKJ-QYZOEREBSA-N 50465773 CHEMBL4277250 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 20 ChEMBL 10.1016/j.bmcl.2018.09.036 10.7270/Q28W3H0D 30327146 Seefeld, MA; Lin, H; Holenz, J; Downie, D; Donovan, B; Fu, T; Pasikanti, K; Zhen, W; Cato, M; Chaudhary, KW; Brady, P; Bakshi, T; Morrow, D; Rajagopal, S; Samanta, SK; Madhyastha, N; Kuppusamy, BM; Dougherty, RW; Bhamidipati, R; Mohd, Z; Higgins, GA; Chapman, M; Rouget, C; Lluel, P; Matsuoka, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50465773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50465773&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 145982955 433933038 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51135773 OC[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1cccc(Cl)c1 InChI=1S/C21H22ClF2NO2/c22-16-8-4-7-15(11-16)19(13-26)25-20(27)18-12-21(23,24)10-9-17(18)14-5-2-1-3-6-14/h1-8,11,17-19,26H,9-10,12-13H2,(H,25,27)/t17-,18+,19+/m1/s1 PJLHZPFIYHRJJO-QYZOEREBSA-N 50465774 CHEMBL4287894 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 100 ChEMBL 10.1016/j.bmcl.2018.09.036 10.7270/Q28W3H0D 30327146 Seefeld, MA; Lin, H; Holenz, J; Downie, D; Donovan, B; Fu, T; Pasikanti, K; Zhen, W; Cato, M; Chaudhary, KW; Brady, P; Bakshi, T; Morrow, D; Rajagopal, S; Samanta, SK; Madhyastha, N; Kuppusamy, BM; Dougherty, RW; Bhamidipati, R; Mohd, Z; Higgins, GA; Chapman, M; Rouget, C; Lluel, P; Matsuoka, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50465774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50465774&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 145993164 433933039 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51135780 C[C@H](NC(=O)c1cc(F)c(F)cc1Oc1ccccc1)c1cccc(c1)S(C)(=O)=O InChI=1S/C22H19F2NO4S/c1-14(15-7-6-10-17(11-15)30(2,27)28)25-22(26)18-12-19(23)20(24)13-21(18)29-16-8-4-3-5-9-16/h3-14H,1-2H3,(H,25,26)/t14-/m0/s1 LZLSVJXKYDXMGI-AWEZNQCLSA-N 50465777 CHEMBL4288707 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 160 ChEMBL 10.1016/j.bmcl.2018.09.036 10.7270/Q28W3H0D 30327146 Seefeld, MA; Lin, H; Holenz, J; Downie, D; Donovan, B; Fu, T; Pasikanti, K; Zhen, W; Cato, M; Chaudhary, KW; Brady, P; Bakshi, T; Morrow, D; Rajagopal, S; Samanta, SK; Madhyastha, N; Kuppusamy, BM; Dougherty, RW; Bhamidipati, R; Mohd, Z; Higgins, GA; Chapman, M; Rouget, C; Lluel, P; Matsuoka, Y GlaxoSmithKline http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50465777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50465777&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 145990965 433933042 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51277198 CCOC(=O)Nc1ccc(cc1NC(=O)OCC)N(CC#C)Cc1ccc(F)cc1 InChI=1S/C22H24FN3O4/c1-4-13-26(15-16-7-9-17(23)10-8-16)18-11-12-19(24-21(27)29-5-2)20(14-18)25-22(28)30-6-3/h1,7-12,14H,5-6,13,15H2,2-3H3,(H,24,27)(H,25,28) IXCVFHVYOARRRS-UHFFFAOYSA-N 50521287 CHEMBL4448132 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 890 ChEMBL 10.1021/acsmedchemlett.8b00315 10.7270/Q2NP27TT 30655942 Wang, L; Qiao, GH; Hu, HN; Gao, ZB; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521287&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 90377311 440729869 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51277199 CCOC(=O)Nc1cc(ccc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1 InChI=1S/C24H28FN3O4/c1-6-14-28(16-17-8-10-18(25)11-9-17)19-12-13-20(26-23(30)32-24(3,4)5)21(15-19)27-22(29)31-7-2/h1,8-13,15H,7,14,16H2,2-5H3,(H,26,30)(H,27,29) PHUNLNCZCLKHCM-UHFFFAOYSA-N 50521288 CHEMBL4438770 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 1420 ChEMBL 10.1021/acsmedchemlett.8b00315 10.7270/Q2NP27TT 30655942 Wang, L; Qiao, GH; Hu, HN; Gao, ZB; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521288 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521288&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 155513238 440729870 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51277200 CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21) PCOBBVZJEWWZFR-UHFFFAOYSA-N 50143558 CHEMBL41355::EZOGABINE::N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethylester::RETIGABINE::[2-Amino-4-(4-fluoro-benzylamino)-phenyl]-carbamic acid ethyl ester Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 5900 ChEMBL 10.1021/acsmedchemlett.8b00315 10.7270/Q2NP27TT 30655942 Wang, L; Qiao, GH; Hu, HN; Gao, ZB; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143558&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search FBX 7CR7,7CR2,7BYM 121892 104032719 68584 CHEMBL41355 DB04953 2601 C13826 ZINC00016154 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51277204 CC(C)(C)OC(=O)Nc1ccc(cc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1 InChI=1S/C26H32FN3O4/c1-8-15-30(17-18-9-11-19(27)12-10-18)20-13-14-21(28-23(31)33-25(2,3)4)22(16-20)29-24(32)34-26(5,6)7/h1,9-14,16H,15,17H2,2-7H3,(H,28,31)(H,29,32) RWGLOYVKHMTDFT-UHFFFAOYSA-N 50521286 CHEMBL4450214 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 2030 ChEMBL 10.1021/acsmedchemlett.8b00315 10.7270/Q2NP27TT 30655942 Wang, L; Qiao, GH; Hu, HN; Gao, ZB; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521286&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 155521071 440729868 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51277206 CCOC(=O)Nc1ccc(cc1NC(=O)OC(C)(C)C)N(CC#C)Cc1ccc(F)cc1 InChI=1S/C24H28FN3O4/c1-6-14-28(16-17-8-10-18(25)11-9-17)19-12-13-20(26-22(29)31-7-2)21(15-19)27-23(30)32-24(3,4)5/h1,8-13,15H,7,14,16H2,2-5H3,(H,26,29)(H,27,30) FWQHRZXEQNUCSY-UHFFFAOYSA-N 50521289 CHEMBL4588394 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 780 ChEMBL 10.1021/acsmedchemlett.8b00315 10.7270/Q2NP27TT 30655942 Wang, L; Qiao, GH; Hu, HN; Gao, ZB; Nan, FJ Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521289 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521289&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 155567226 440729871 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51292698 CCCCCCC(=O)Nc1ccc2n(Cc3ccc(cc3)C(F)(F)F)ccc2c1 InChI=1S/C23H25F3N2O/c1-2-3-4-5-6-22(29)27-20-11-12-21-18(15-20)13-14-28(21)16-17-7-9-19(10-8-17)23(24,25)26/h7-15H,2-6,16H2,1H3,(H,27,29) YOOQNABHIRSAHK-UHFFFAOYSA-N 50526877 CHEMBL4545892 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 100 ChEMBL 10.1021/acs.jmedchem.9b00796 10.7270/Q2KW5KG2 31815462 Ostacolo, C; Miceli, F; Di Sarno, V; Nappi, P; Iraci, N; Soldovieri, MV; Ciaglia, T; Ambrosino, P; Vestuto, V; Lauritano, A; Musella, S; Pepe, G; Basilicata, MG; Manfra, M; Perinelli, DR; Novellino, E; Bertamino, A; Gomez-Monterrey, IM; Campiglia, P; Taglialatela, M University Federico II of Naples http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526877&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 155491024 440735459 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51292699 CC(C)(C)CC(=O)Nc1ccc2n(Cc3ccc(cc3)C(F)(F)F)ccc2c1 InChI=1S/C22H23F3N2O/c1-21(2,3)13-20(28)26-18-8-9-19-16(12-18)10-11-27(19)14-15-4-6-17(7-5-15)22(23,24)25/h4-12H,13-14H2,1-3H3,(H,26,28) UPJZNVXWEWWVLT-UHFFFAOYSA-N 50526876 CHEMBL4457044 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 80 ChEMBL 10.1021/acs.jmedchem.9b00796 10.7270/Q2KW5KG2 31815462 Ostacolo, C; Miceli, F; Di Sarno, V; Nappi, P; Iraci, N; Soldovieri, MV; Ciaglia, T; Ambrosino, P; Vestuto, V; Lauritano, A; Musella, S; Pepe, G; Basilicata, MG; Manfra, M; Perinelli, DR; Novellino, E; Bertamino, A; Gomez-Monterrey, IM; Campiglia, P; Taglialatela, M University Federico II of Naples http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526876&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 155491025 440735458 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51292704 CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)cc1N InChI=1S/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21) PCOBBVZJEWWZFR-UHFFFAOYSA-N 50143558 CHEMBL41355::EZOGABINE::N-(2-amino-4-(4-fluorobenzylamino)-phenyl)carbamic acid ethylester::RETIGABINE::[2-Amino-4-(4-fluoro-benzylamino)-phenyl]-carbamic acid ethyl ester Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 1980 ChEMBL 10.1021/acs.jmedchem.9b00796 10.7270/Q2KW5KG2 31815462 Ostacolo, C; Miceli, F; Di Sarno, V; Nappi, P; Iraci, N; Soldovieri, MV; Ciaglia, T; Ambrosino, P; Vestuto, V; Lauritano, A; Musella, S; Pepe, G; Basilicata, MG; Manfra, M; Perinelli, DR; Novellino, E; Bertamino, A; Gomez-Monterrey, IM; Campiglia, P; Taglialatela, M University Federico II of Naples http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50143558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50143558&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search FBX 7CR7,7CR2,7BYM 121892 104032719 68584 CHEMBL41355 DB04953 2601 C13826 ZINC00016154 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51467942 Nc1c(F)c(NCc2ncc(cc2F)C(F)(F)F)c(F)c(F)c1NC(=O)OC1CC1 InChI=1S/C17H13F7N4O2/c18-8-3-6(17(22,23)24)4-26-9(8)5-27-14-10(19)11(20)15(13(25)12(14)21)28-16(29)30-7-1-2-7/h3-4,7,27H,1-2,5,25H2,(H,28,29) WTJDJRDSKNQFBM-UHFFFAOYSA-N 50592355 CHEMBL5200636 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 320 ChEMBL 10.7270/Q2571H05 35671848 Hernandez, CC; Tarfa, RA; Miguel I Limcaoco, J; Liu, R; Mondal, P; Hill, C; Keith Duncan, R; Tzounopoulos, T; Stephenson, CRJ; O'Meara, MJ; Wipf, P University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592355&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 168292139 482603207 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51467943 Nc1c(F)c(NCc2ccc(cc2)C(F)(F)F)ccc1NC(=O)OC1CC1 InChI=1S/C18H17F4N3O2/c19-15-13(24-9-10-1-3-11(4-2-10)18(20,21)22)7-8-14(16(15)23)25-17(26)27-12-5-6-12/h1-4,7-8,12,24H,5-6,9,23H2,(H,25,26) ABYIXDBMGLFCSO-UHFFFAOYSA-N 50592356 CHEMBL4458793 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 910 ChEMBL 10.7270/Q2571H05 35671848 Hernandez, CC; Tarfa, RA; Miguel I Limcaoco, J; Liu, R; Mondal, P; Hill, C; Keith Duncan, R; Tzounopoulos, T; Stephenson, CRJ; O'Meara, MJ; Wipf, P University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592356&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 139593251 482603208 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51467944 CCOC(=O)Nc1cc(F)c(NCc2ccc(cc2)C(F)(F)F)c(F)c1N InChI=1S/C17H16F5N3O2/c1-2-27-16(26)25-12-7-11(18)15(13(19)14(12)23)24-8-9-3-5-10(6-4-9)17(20,21)22/h3-7,24H,2,8,23H2,1H3,(H,25,26) DLTUKHNOWLHZDN-UHFFFAOYSA-N 50592357 CHEMBL5185685 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 87 ChEMBL 10.7270/Q2571H05 35671848 Hernandez, CC; Tarfa, RA; Miguel I Limcaoco, J; Liu, R; Mondal, P; Hill, C; Keith Duncan, R; Tzounopoulos, T; Stephenson, CRJ; O'Meara, MJ; Wipf, P University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592357&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 168279224 482603209 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51467945 CCOC(=O)Nc1ccc(NCc2ccc(nc2)C(F)(F)F)c(F)c1N InChI=1S/C16H16F4N4O2/c1-2-26-15(25)24-11-5-4-10(13(17)14(11)21)22-7-9-3-6-12(23-8-9)16(18,19)20/h3-6,8,22H,2,7,21H2,1H3,(H,24,25) QGMYAHJROPECLZ-UHFFFAOYSA-N 50592360 CHEMBL4549229 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 660 ChEMBL 10.7270/Q2571H05 35671848 Hernandez, CC; Tarfa, RA; Miguel I Limcaoco, J; Liu, R; Mondal, P; Hill, C; Keith Duncan, R; Tzounopoulos, T; Stephenson, CRJ; O'Meara, MJ; Wipf, P University of Michigan http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50592360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50592360&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 146202071 482603212 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025 51473399 Cc1ccc(CSCc2nnc(SCC(=O)Nc3ccc(Br)cc3Br)n2C)cc1 InChI=1S/C20H20Br2N4OS2/c1-13-3-5-14(6-4-13)10-28-11-18-24-25-20(26(18)2)29-12-19(27)23-17-8-7-15(21)9-16(17)22/h3-9H,10-12H2,1-2H3,(H,23,27) WMAKXXYICWYYJD-UHFFFAOYSA-N 50594442 CHEMBL5178988 Potassium voltage-gated channel subfamily KQT member 4 Homo sapiens 6400 ChEMBL 10.7270/Q2GQ72RJ 35878013 Liu, S; Guo, P; Wang, K; Zhang, S; Li, Y; Shen, J; Mei, L; Ye, Y; Zhang, Q; Yang, H East China Normal University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50594442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001237&target=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50594442&enzyme=Potassium+voltage-gated+channel+subfamily+KQT+member+4&column=ki&startPg=0&Increment=50&submit=Search 164946930 482605294 1 MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD 4GOW,7BYL,7BYM,7BYN Potassium voltage-gated channel subfamily KQT member 4 KCNQ4_HUMAN P56696 O96025