BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50189947 ONC(=O)[C@H]1CCCOC(=O)NCCCC[C@H](NC(=O)[C@@H]1Cc1ccc(cc1)-c1ccccc1C(F)(F)F)C(=O)NCC(=O)N1CCNCC1 InChI=1S/C34H43F3N6O7/c35-34(36,37)27-8-2-1-6-24(27)23-12-10-22(11-13-23)20-26-25(31(46)42-49)7-5-19-50-33(48)39-14-4-3-9-28(41-30(26)45)32(47)40-21-29(44)43-17-15-38-16-18-43/h1-2,6,8,10-13,25-26,28,38,49H,3-5,7,9,14-21H2,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t25-,26+,28-/m0/s1 DQLDJYJWPVFOFC-REUBFRLUSA-N 50104973 2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-oxo-2-piperazin-1-yl-ethyl)-amide]::CHEMBL431680 Matrix metalloproteinase-16 Homo sapiens >2000 ChEMBL 10.1021/jm0155502 10.7270/Q2VD6XRT 11585440 Xue, CB; He, X; Corbett, RL; Roderick, J; Wasserman, ZR; Liu, RQ; Jaffee, BD; Covington, MB; Qian, M; Trzaskos, JM; Newton, RC; Magolda, RL; Wexler, RR; Decicco, CP DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104973&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 10009978 104000770 CHEMBL431680 ZINC26989852 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50189968 ONC(=O)[C@H]1CCCOC(=O)NCCCC[C@H](NC(=O)[C@@H]1Cc1ccc(cc1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)NCC(=O)N1CCNCC1 InChI=1S/C35H42F6N6O7/c36-34(37,38)24-17-23(18-25(19-24)35(39,40)41)22-8-6-21(7-9-22)16-27-26(31(50)46-53)4-3-15-54-33(52)43-10-2-1-5-28(45-30(27)49)32(51)44-20-29(48)47-13-11-42-12-14-47/h6-9,17-19,26-28,42,53H,1-5,10-16,20H2,(H,43,52)(H,44,51)(H,45,49)(H,46,50)/t26-,27+,28-/m0/s1 LCWWOMJWYGNKJF-IARZGTGTSA-N 50104976 11-(3',5'-Bis-trifluoromethyl-biphenyl-4-ylmethyl)-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-oxo-2-piperazin-1-yl-ethyl)-amide]::CHEMBL114878 Matrix metalloproteinase-16 Homo sapiens >2000 ChEMBL 10.1021/jm0155502 10.7270/Q2VD6XRT 11585440 Xue, CB; He, X; Corbett, RL; Roderick, J; Wasserman, ZR; Liu, RQ; Jaffee, BD; Covington, MB; Qian, M; Trzaskos, JM; Newton, RC; Magolda, RL; Wexler, RR; Decicco, CP DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104976&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 11967143 104000773 CHEMBL114878 ZINC95546500 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50189969 ONC(=O)[C@H]1CCCOC(=O)NCCCC[C@H](NC(=O)[C@@H]1Cc1ccc(cc1)-c1ccccc1C(F)(F)F)C(=O)NCC(=O)N1CCOCC1 InChI=1S/C34H42F3N5O8/c35-34(36,37)27-8-2-1-6-24(27)23-12-10-22(11-13-23)20-26-25(31(45)41-48)7-5-17-50-33(47)38-14-4-3-9-28(40-30(26)44)32(46)39-21-29(43)42-15-18-49-19-16-42/h1-2,6,8,10-13,25-26,28,48H,3-5,7,9,14-21H2,(H,38,47)(H,39,46)(H,40,44)(H,41,45)/t25-,26+,28-/m0/s1 RWKJBOMUESGCBO-REUBFRLUSA-N 50104975 (8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide]::(8S,11R,12S)-N12-hydroxy-N8-(2-morpholino-2-oxoethyl)-2,10-dioxo-11-((2'-(trifluoromethyl)biphenyl-4-yl)methyl)-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamide::2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide]::CHEMBL325163 Matrix metalloproteinase-16 Homo sapiens 2000 ChEMBL 10.1021/jm0155502 10.7270/Q2VD6XRT 11585440 Xue, CB; He, X; Corbett, RL; Roderick, J; Wasserman, ZR; Liu, RQ; Jaffee, BD; Covington, MB; Qian, M; Trzaskos, JM; Newton, RC; Magolda, RL; Wexler, RR; Decicco, CP DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104975&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 10395015 104000772 CHEMBL325163 ZINC03944005 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50189974 NC(=O)CNC(=O)[C@@H]1CCCCNC(=O)OCCC[C@@H]([C@@H](Cc2ccc(cc2)-c2ccccc2C(F)(F)F)C(=O)N1)C(=O)NO InChI=1S/C30H36F3N5O7/c31-30(32,33)23-8-2-1-6-20(23)19-12-10-18(11-13-19)16-22-21(27(41)38-44)7-5-15-45-29(43)35-14-4-3-9-24(37-26(22)40)28(42)36-17-25(34)39/h1-2,6,8,10-13,21-22,24,44H,3-5,7,9,14-17H2,(H2,34,39)(H,35,43)(H,36,42)(H,37,40)(H,38,41)/t21-,22+,24-/m0/s1 SOPDPCOBVSOXIM-ZDXQCDESSA-N 50104974 2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 8-carbamoylmethyl-amide 12-hydroxyamide::CHEMBL115263 Matrix metalloproteinase-16 Homo sapiens >2000 ChEMBL 10.1021/jm0155502 10.7270/Q2VD6XRT 11585440 Xue, CB; He, X; Corbett, RL; Roderick, J; Wasserman, ZR; Liu, RQ; Jaffee, BD; Covington, MB; Qian, M; Trzaskos, JM; Newton, RC; Magolda, RL; Wexler, RR; Decicco, CP DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104974 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104974&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 10439082 104000771 CHEMBL115263 ZINC26997569 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50218491 C[C@@H](N1CC[C@](C)(C1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO InChI=1S/C25H27N3O4/c1-16-14-18(21-6-4-5-7-22(21)26-16)15-32-20-10-8-19(9-11-20)25(3)12-13-28(24(25)30)17(2)23(29)27-31/h4-11,14,17,31H,12-13,15H2,1-3H3,(H,27,29)/t17-,25+/m1/s1 YDMIPBHQKFOFQW-NSYGIPOTSA-N 26526 (2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylquinolin-4-yl)methoxy]phenyl}-2-oxopyrrolidin-1-yl]propanamide::BMCL181958 Compound 1::CHEMBL148169::IK682 Matrix metalloproteinase-16 Homo sapiens 1599 ChEMBL 10.1021/jm0255670 10.7270/Q2XP7497 12408705 Duan, JJ; Chen, L; Wasserman, ZR; Lu, Z; Liu, RQ; Covington, MB; Qian, M; Hardman, KD; Magolda, RL; Newton, RC; Christ, DD; Wexler, RR; Decicco, CP Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26526&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 541 2FV5 6914621 56464963 40083 CHEMBL148169 DB07145 ZINC03820969 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251602 ONC(=O)C1N(CCc2cc(OCc3ccccc3)ccc12)S(=O)(=O)c1cc(Cl)ccc1Cl InChI=1S/C23H20Cl2N2O5S/c24-17-6-9-20(25)21(13-17)33(30,31)27-11-10-16-12-18(32-14-15-4-2-1-3-5-15)7-8-19(16)22(27)23(28)26-29/h1-9,12-13,22,29H,10-11,14H2,(H,26,28) XLTGYQNRFLYPNU-UHFFFAOYSA-N 50137280 6-Benzyloxy-2-(2,5-dichloro-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL147604 Matrix metalloproteinase-16 Homo sapiens 4633 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137280&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364251 104027446 CHEMBL147604 ZINC13588273 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251611 Nc1ccc(cc1)S(=O)(=O)N1CCc2cc(O)ccc2C1C(=O)NO InChI=1S/C16H17N3O5S/c17-11-1-4-13(5-2-11)25(23,24)19-8-7-10-9-12(20)3-6-14(10)15(19)16(21)18-22/h1-6,9,15,20,22H,7-8,17H2,(H,18,21) VVZFBVIPGIVQRI-UHFFFAOYSA-N 50137277 2-(4-Amino-benzenesulfonyl)-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL148406 Matrix metalloproteinase-16 Homo sapiens 202 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137277&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364111 104027443 CHEMBL148406 ZINC13588261 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251612 COc1cc2C(N(CCc2cc1O)S(=O)(=O)c1ccccc1)C(=O)NO InChI=1S/C17H18N2O6S/c1-25-15-10-13-11(9-14(15)20)7-8-19(16(13)17(21)18-22)26(23,24)12-5-3-2-4-6-12/h2-6,9-10,16,20,22H,7-8H2,1H3,(H,18,21) JOGYGVFUVCZABB-UHFFFAOYSA-N 50137281 2-Benzenesulfonyl-6-hydroxy-7-methoxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL148171::N,6-dihydroxy-7-methoxy-2-(phenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide Matrix metalloproteinase-16 Homo sapiens 40 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137281&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364250 104027447 CHEMBL148171 ZINC13588275 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251622 COc1ccc(cc1)S(=O)(=O)N1CCc2cc(O)ccc2C1C(=O)NO InChI=1S/C17H18N2O6S/c1-25-13-3-5-14(6-4-13)26(23,24)19-9-8-11-10-12(20)2-7-15(11)16(19)17(21)18-22/h2-7,10,16,20,22H,8-9H2,1H3,(H,18,21) ZJOQXNGTEXFLLO-UHFFFAOYSA-N 50137286 6-Hydroxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL356124 Matrix metalloproteinase-16 Homo sapiens 1677 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137286&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364280 104027452 CHEMBL356124 ZINC13588259 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251626 COc1ccc(cc1)S(=O)(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NO InChI=1S/C24H24N2O6S/c1-31-19-7-10-21(11-8-19)33(29,30)26-14-13-18-15-20(32-16-17-5-3-2-4-6-17)9-12-22(18)23(26)24(27)25-28/h2-12,15,23,28H,13-14,16H2,1H3,(H,25,27) OVUDWXYTKUKYAX-UHFFFAOYSA-N 50137283 6-(benzyloxy)-N-hydroxy-2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide::6-Benzyloxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL358539 Matrix metalloproteinase-16 Homo sapiens 22 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137283&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 10367355 104027449 CHEMBL358539 ZINC13588271 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251634 ONC(=O)C1N(CCc2cc(OCc3ccccc3)ccc12)S(=O)(=O)c1ccccc1 InChI=1S/C23H22N2O5S/c26-23(24-27)22-21-12-11-19(30-16-17-7-3-1-4-8-17)15-18(21)13-14-25(22)31(28,29)20-9-5-2-6-10-20/h1-12,15,22,27H,13-14,16H2,(H,24,26) YVCCTHCWKOIESX-UHFFFAOYSA-N 50137287 2-Benzenesulfonyl-6-benzyloxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::6-(benzyloxy)-N-hydroxy-2-(phenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide::CHEMBL147881 Matrix metalloproteinase-16 Homo sapiens 35 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137287&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364121 104027453 CHEMBL147881 ZINC13588267 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251640 ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1ccccc1 InChI=1S/C16H16N2O5S/c19-12-6-7-14-11(10-12)8-9-18(15(14)16(20)17-21)24(22,23)13-4-2-1-3-5-13/h1-7,10,15,19,21H,8-9H2,(H,17,20) NOENPCOHNDAVLW-UHFFFAOYSA-N 50137284 2-Benzenesulfonyl-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL146289 Matrix metalloproteinase-16 Homo sapiens 184 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137284&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364224 104027450 CHEMBL146289 ZINC13588255 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251641 COc1ccc(cc1)S(=O)(=O)N1CCc2cc(O)c(OC)cc2C1C(=O)NO InChI=1S/C18H20N2O7S/c1-26-12-3-5-13(6-4-12)28(24,25)20-8-7-11-9-15(21)16(27-2)10-14(11)17(20)18(22)19-23/h3-6,9-10,17,21,23H,7-8H2,1-2H3,(H,19,22) AYFCYVLVRYQGME-UHFFFAOYSA-N 50137276 6-Hydroxy-7-methoxy-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL148214::N,6-dihydroxy-7-methoxy-2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide Matrix metalloproteinase-16 Homo sapiens 16 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137276&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search MDW 2DDY 44364249 104027442 CHEMBL148214 ZINC13588277 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251642 ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O InChI=1S/C16H15N3O7S/c20-12-3-6-14-10(9-12)7-8-18(15(14)16(21)17-22)27(25,26)13-4-1-11(2-5-13)19(23)24/h1-6,9,15,20,22H,7-8H2,(H,17,21) YVJXBWDNNWDVMN-UHFFFAOYSA-N 50137279 6-Hydroxy-2-(4-nitro-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL147489::N,6-dihydroxy-2-(4-nitrophenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxamide Matrix metalloproteinase-16 Homo sapiens 177 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137279&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364119 104027445 CHEMBL147489 ZINC13588263 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251661 Cc1ccc(cc1)S(=O)(=O)N1CCc2cc(O)ccc2C1C(=O)NO InChI=1S/C17H18N2O5S/c1-11-2-5-14(6-3-11)25(23,24)19-9-8-12-10-13(20)4-7-15(12)16(19)17(21)18-22/h2-7,10,16,20,22H,8-9H2,1H3,(H,18,21) PFIFGQWOKBQYID-UHFFFAOYSA-N 50137282 6-Hydroxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL147882::N,6-dihydroxy-2-tosyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamide Matrix metalloproteinase-16 Homo sapiens 21 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137282&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364122 104027448 CHEMBL147882 ZINC13588257 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251665 Cc1ccc(cc1)S(=O)(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NO InChI=1S/C24H24N2O5S/c1-17-7-10-21(11-8-17)32(29,30)26-14-13-19-15-20(31-16-18-5-3-2-4-6-18)9-12-22(19)23(26)24(27)25-28/h2-12,15,23,28H,13-14,16H2,1H3,(H,25,27) RILFWDKQYPJIOQ-UHFFFAOYSA-N 50137285 6-(benzyloxy)-N-hydroxy-2-tosyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamide::6-Benzyloxy-2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::CHEMBL146718 Matrix metalloproteinase-16 Homo sapiens 56.0 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137285&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364037 104027451 CHEMBL146718 ZINC13588269 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251669 ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1cc(Cl)ccc1Cl InChI=1S/C16H14Cl2N2O5S/c17-10-1-4-13(18)14(8-10)26(24,25)20-6-5-9-7-11(21)2-3-12(9)15(20)16(22)19-23/h1-4,7-8,15,21,23H,5-6H2,(H,19,22) QMIAXILIKVOPKK-UHFFFAOYSA-N 50137278 2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::2-(2,5-dichlorophenylsulfonyl)-N,6-dihydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamide::CHEMBL424130 Matrix metalloproteinase-16 Homo sapiens 1839 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137278&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364266 104027444 CHEMBL424130 ZINC13588265 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50251691 CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1 NITYDPDXAAFEIT-DYVFJYSZSA-N 50062351 (R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide::(R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide::(R)-N1-((S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide::3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE::CHEMBL19611::Ilomastat::US9487462, ilomastat Matrix metalloproteinase-16 Homo sapiens 8 ChEMBL 10.1016/j.bmcl.2003.10.026 10.7270/Q22J6B79 14684295 Ma, D; Wu, W; Yang, G; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062351&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search GM6 2DW1,2DW0,1PWU,2ERP,2E3X,4PKW 132519 103957874 CHEMBL19611 DB02255 ZINC03780014 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50339943 Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCNCC2)c2ccccc2n1 InChI=1S/C25H28N4O4/c1-17-14-19(21-4-2-3-5-22(21)27-17)16-33-20-8-6-18(7-9-20)24(31)28-25(15-23(30)29-32)10-12-26-13-11-25/h2-9,14,26,32H,10-13,15-16H2,1H3,(H,28,31)(H,29,30) BODLESUVCQEUII-UHFFFAOYSA-N 50183711 CHEMBL208009::N-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide Matrix metalloproteinase-16 Homo sapiens >5554 ChEMBL 10.1016/j.bmcl.2006.02.015 10.7270/Q2TB16H3 16516466 Gilmore, JL; King, BW; Harris, C; Maduskuie, T; Mercer, SE; Liu, RQ; Covington, MB; Qian, M; Ribadeneria, MD; Vaddi, K; Trzaskos, JM; Newton, RC; Decicco, CP; Duan, JJ Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50183711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50183711&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 10160968 104068145 CHEMBL208009 ZINC34355011 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50340067 Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCOCC2)c2ccccc2n1 InChI=1S/C25H27N3O5/c1-17-14-19(21-4-2-3-5-22(21)26-17)16-33-20-8-6-18(7-9-20)24(30)27-25(15-23(29)28-31)10-12-32-13-11-25/h2-9,14,31H,10-13,15-16H2,1H3,(H,27,30)(H,28,29) NUVSGXIVCJBRBF-UHFFFAOYSA-N 50183715 CHEMBL207305::N-(4-(2-(hydroxyamino)-2-oxoethyl)-tetrahydro-2H-pyran-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide::N-(4-(2-(hydroxyamino)-2-oxoethyl)tetrahydro-2H-pyran-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide Matrix metalloproteinase-16 Homo sapiens >5554 ChEMBL 10.1016/j.bmcl.2006.02.015 10.7270/Q2TB16H3 16516466 Gilmore, JL; King, BW; Harris, C; Maduskuie, T; Mercer, SE; Liu, RQ; Covington, MB; Qian, M; Ribadeneria, MD; Vaddi, K; Trzaskos, JM; Newton, RC; Decicco, CP; Duan, JJ Bristol-Myers Squibb Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50183715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50183715&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 9868333 104068149 CHEMBL207305 ZINC03817205 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50334522 CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)CC(=O)NO InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1 NITYDPDXAAFEIT-DYVFJYSZSA-N 50062351 (R)-N*4*-Hydroxy-N*1*-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide::(R)-N*4*-Hydroxy-N*1*-[2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide::(R)-N1-((S)-3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide::3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE::CHEMBL19611::Ilomastat::US9487462, ilomastat Matrix metalloproteinase-16 Homo sapiens 8 ChEMBL 10.1021/jm051101g 10.7270/Q2WQ03C3 16420030 Ma, D; Jiang, Y; Chen, F; Gong, LK; Ding, K; Xu, Y; Wang, R; Ge, A; Ren, J; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062351&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search GM6 2DW1,2DW0,1PWU,2ERP,2E3X,4PKW 132519 103957874 CHEMBL19611 DB02255 ZINC03780014 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50334538 CCC(CC(O)=O)C(=O)c1ccc(cc1)C#Cc1ccccc1 InChI=1S/C20H18O3/c1-2-17(14-19(21)22)20(23)18-12-10-16(11-13-18)9-8-15-6-4-3-5-7-15/h3-7,10-13,17H,2,14H2,1H3,(H,21,22) OQWWYXZJKRAMIK-UHFFFAOYSA-N 50180601 3-(4-(2-phenylethynyl)benzoyl)pentanoic acid::CHEMBL202875 Matrix metalloproteinase-16 Homo sapiens 32040 ChEMBL 10.1021/jm051101g 10.7270/Q2WQ03C3 16420030 Ma, D; Jiang, Y; Chen, F; Gong, LK; Ding, K; Xu, Y; Wang, R; Ge, A; Ren, J; Li, J; Li, J; Ye, Q Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50180601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50180601&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 11609208 104065657 CHEMBL202875 ZINC13679382 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50442650 NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(cc2)-c2ccccc2)cc1 InChI=1S/C24H26N4O7S2/c25-36(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)37(34,35)22-12-8-20(9-13-22)19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33) LQNSDZTXHZUYKJ-UHFFFAOYSA-N 50241253 2-[(biphenyl-4-sulfonyl)-hydroxycarbamoylmethyl-amino]-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide::CHEMBL234735::N-(4-Biphenylsulfonyl)-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]-methyl}aminoacetohydroxamic Acid Matrix metalloproteinase-16 Homo sapiens 186 ChEMBL 10.1021/jm800964f 10.7270/Q2XK8FDN 19053764 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Instituto Superior Técnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241253 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241253&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 25181081 104098679 CHEMBL234735 ZINC28819192 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50442659 NS(=O)(=O)c1ccc(CCNC(=O)CN(CC(=O)NO)S(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1 InChI=1S/C24H26N4O8S2/c25-37(32,33)21-10-6-18(7-11-21)14-15-26-23(29)16-28(17-24(30)27-31)38(34,35)22-12-8-20(9-13-22)36-19-4-2-1-3-5-19/h1-13,31H,14-17H2,(H,26,29)(H,27,30)(H2,25,32,33) HFLSBITWFGZVGL-UHFFFAOYSA-N 50241252 2-[hydroxycarbamoylmethyl-(4-phenoxy-benzenesulfonyl)-amino]-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide::CHEMBL234530::N-(4-Phenoxybenzenesulfonyl)-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}aminoacetohydroxamic Acid Matrix metalloproteinase-16 Homo sapiens 1 ChEMBL 10.1021/jm800964f 10.7270/Q2XK8FDN 19053764 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Instituto Superior Técnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241252&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 25178145 104098678 CHEMBL234530 ZINC28819190 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50442669 CC(C)[C@@H](N(CC(=O)NCCc1ccc(cc1)S(N)(=O)=O)S(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO InChI=1S/C27H32N4O8S2/c1-19(2)26(27(33)30-34)31(18-25(32)29-17-16-20-8-12-23(13-9-20)40(28,35)36)41(37,38)24-14-10-22(11-15-24)39-21-6-4-3-5-7-21/h3-15,19,26,34H,16-18H2,1-2H3,(H,29,32)(H,30,33)(H2,28,35,36)/t26-/m1/s1 GSWRTFGMHRKLKT-AREMUKBSSA-N 50246599 CHEMBL471537::N-(4-Phenoxybenzenesulfonyl)-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}-D-valinehydroxamic Acid Matrix metalloproteinase-16 Homo sapiens 0.310000 ChEMBL 10.1021/jm800964f 10.7270/Q2XK8FDN 19053764 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Instituto Superior Técnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246599&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 25147773 104101989 CHEMBL471537 ZINC44417816 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50442680 COc1ccc(cc1)S(=O)(=O)N(CC(O)=O)CC(=O)NO InChI=1S/C11H14N2O7S/c1-20-8-2-4-9(5-3-8)21(18,19)13(7-11(15)16)6-10(14)12-17/h2-5,17H,6-7H2,1H3,(H,12,14)(H,15,16) QVAVQQVTOJMLHH-UHFFFAOYSA-N 50246600 2-(N-(2-(hydroxyamino)-2-oxoethyl)-4-methoxyphenylsulfonamido)acetic acid::CHEMBL515083 Matrix metalloproteinase-16 Homo sapiens 996 ChEMBL 10.1021/jm800964f 10.7270/Q2XK8FDN 19053764 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Instituto Superior Técnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246600&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44563337 104101990 CHEMBL515083 ZINC40407300 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50442687 ONC(=O)CN(CC(O)=O)S(=O)(=O)c1ccc(Oc2ccccc2)cc1 InChI=1S/C16H16N2O7S/c19-15(17-22)10-18(11-16(20)21)26(23,24)14-8-6-13(7-9-14)25-12-4-2-1-3-5-12/h1-9,22H,10-11H2,(H,17,19)(H,20,21) ZRAUMSIZBNBIFE-UHFFFAOYSA-N 50246601 2-(N-(2-(hydroxyamino)-2-oxoethyl)-4-phenoxyphenylsulfonamido)acetic acid::CHEMBL472899 Matrix metalloproteinase-16 Homo sapiens 11 ChEMBL 10.1021/jm800964f 10.7270/Q2XK8FDN 19053764 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Instituto Superior Técnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50246601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50246601&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 16126723 104101991 CHEMBL472899 ZINC35328137 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50442694 COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO InChI=1S/C18H23N3O5S/c1-13(2)17(18(22)20-23)21(12-14-5-4-10-19-11-14)27(24,25)16-8-6-15(26-3)7-9-16/h4-11,13,17,23H,12H2,1-3H3,(H,20,22)/t17-/m1/s1 BSIZUMJRKYHEBR-QGZVFWFLSA-N 50066658 (R)-N-(1-(hydroxyamino)-2-methylpropyl)-4-methoxy-N-(pyridin-3-ylmethyl)benzenesulfonamide hydrochloride::(R)-N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-butyramide::(R)-N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-butyramide; hydrochloride::(R)-N-Hydroxy-2-isopropyl-3-(4-methoxy-benzenesulfonyl)-4-pyridin-3-yl-butyramide; hydrochloride::(R)-N-hydroxy-2-(4-methoxy-N-(pyridin-3-ylmethyl)phenylsulfonamido)-3-methylbutanamide::(S)-N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-butyramide::(S)-N-hydroxy-2-(4-methoxy-N-(pyridin-3-ylmethyl)phenylsulfonamido)-3-methylbutanamide::2-[Benzyl-(4-methoxy-benzenesulfonyl)-amino]-N-hydroxy-3-methyl-butyramide(CGS-27023A)::3-[((R)-1-Hydroxycarbamoyl-2-methyl-propylamino)-methyl]-pyridine-4-sulfonic acid methyl ester::CGS-27023::CGS-27023A::CHEMBL514138::N-Hydroxy-2-[(4-methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-butyramide::N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)-amino]-3-methyl-butanamide Matrix metalloproteinase-16 Homo sapiens 6.8 ChEMBL 10.1021/jm800964f 10.7270/Q2XK8FDN 19053764 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Instituto Superior Técnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50066658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50066658&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search CGS 4AYK,1JIZ,2W0D,3AYK 446504 103961278 CHEMBL514138 DB07556 ZINC06302114 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50442724 CC(C)[C@@H](N(CC(O)=O)S(=O)(=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO InChI=1S/C19H22N2O7S/c1-13(2)18(19(24)20-25)21(12-17(22)23)29(26,27)16-10-8-15(9-11-16)28-14-6-4-3-5-7-14/h3-11,13,18,25H,12H2,1-2H3,(H,20,24)(H,22,23)/t18-/m1/s1 KBZNOZAJAJRTII-GOSISDBHSA-N 50273426 CHEMBL515980::N-(4-Phenoxybenzenesulfonyl)-N-hydroxycarbonylmethyl-D-valinehydroxamicAcid Matrix metalloproteinase-16 Homo sapiens 1.6 ChEMBL 10.1021/jm800964f 10.7270/Q2XK8FDN 19053764 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Instituto Superior Técnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273426 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273426&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 25180867 104117552 CHEMBL515980 ZINC40848697 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50442749 COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)CC(=O)NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C19H24N4O8S2/c1-31-15-4-8-17(9-5-15)33(29,30)23(13-19(25)22-26)12-18(24)21-11-10-14-2-6-16(7-3-14)32(20,27)28/h2-9,26H,10-13H2,1H3,(H,21,24)(H,22,25)(H2,20,27,28) QSOYTCHABFMDFV-UHFFFAOYSA-N 50241251 2-[hydroxycarbamoylmethyl-(4-methoxy-benzenesulfonyl)-amino]-N-[2-(4-sulfamoyl-phenyl)-ethyl]-acetamide::CHEMBL234529::N-(4-Methoxybenzenesulfonyl)-N-{[2-(4-sulfamoylphenyl)ethylcarbamoyl]methyl}aminoacetohydroxamic Acid Matrix metalloproteinase-16 Homo sapiens 44 ChEMBL 10.1021/jm800964f 10.7270/Q2XK8FDN 19053764 Marques, SM; Nuti, E; Rossello, A; Supuran, CT; Tuccinardi, T; Martinelli, A; Santos, MA Instituto Superior Técnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50241251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50241251&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 25181080 104098677 CHEMBL234529 ZINC28819188 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50432268 C[C@@H](N1CC[C@](C)(C1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO InChI=1S/C25H27N3O4/c1-16-14-18(21-6-4-5-7-22(21)26-16)15-32-20-10-8-19(9-11-20)25(3)12-13-28(24(25)30)17(2)23(29)27-31/h4-11,14,17,31H,12-13,15H2,1-3H3,(H,27,29)/t17-,25+/m1/s1 YDMIPBHQKFOFQW-NSYGIPOTSA-N 26526 (2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylquinolin-4-yl)methoxy]phenyl}-2-oxopyrrolidin-1-yl]propanamide::BMCL181958 Compound 1::CHEMBL148169::IK682 Matrix metalloproteinase-16 Homo sapiens 1599 ChEMBL 10.1016/j.bmc.2008.08.058 10.7270/Q2JD4WM2 18790648 Georgiadis, D; Yiotakis, A University of Athens http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26526&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 541 2FV5 6914621 56464963 40083 CHEMBL148169 DB07145 ZINC03820969 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50432280 ONC(=O)[C@H]1CCCOC(=O)NCCCC[C@H](NC(=O)[C@@H]1Cc1ccc(cc1)-c1ccccc1C(F)(F)F)C(=O)NCC(=O)N1CCOCC1 InChI=1S/C34H42F3N5O8/c35-34(36,37)27-8-2-1-6-24(27)23-12-10-22(11-13-23)20-26-25(31(45)41-48)7-5-17-50-33(47)38-14-4-3-9-28(40-30(26)44)32(46)39-21-29(43)42-15-18-49-19-16-42/h1-2,6,8,10-13,25-26,28,48H,3-5,7,9,14-21H2,(H,38,47)(H,39,46)(H,40,44)(H,41,45)/t25-,26+,28-/m0/s1 RWKJBOMUESGCBO-REUBFRLUSA-N 50104975 (8S,11R,12S)-2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide]::(8S,11R,12S)-N12-hydroxy-N8-(2-morpholino-2-oxoethyl)-2,10-dioxo-11-((2'-(trifluoromethyl)biphenyl-4-yl)methyl)-1-oxa-3,9-diazacyclopentadecane-8,12-dicarboxamide::2,10-Dioxo-11-(2'-trifluoromethyl-biphenyl-4-ylmethyl)-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide]::CHEMBL325163 Matrix metalloproteinase-16 Homo sapiens >2000 ChEMBL 10.1016/j.bmc.2008.08.058 10.7270/Q2JD4WM2 18790648 Georgiadis, D; Yiotakis, A University of Athens http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50104975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50104975&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 10395015 104000772 CHEMBL325163 ZINC03944005 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50432319 ONC(=O)[C@H]1COCC[C@H]1NC(=O)c1ccc(Cn2c(nc3ccccc23)C(F)(F)F)cc1 InChI=1S/C22H21F3N4O4/c23-22(24,25)21-27-17-3-1-2-4-18(17)29(21)11-13-5-7-14(8-6-13)19(30)26-16-9-10-33-12-15(16)20(31)28-32/h1-8,15-16,32H,9-12H2,(H,26,30)(H,28,31)/t15-,16+/m0/s1 PGVYYPZKXKGBLD-JKSUJKDBSA-N 26806 (3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl]methyl}benzene)oxane-3,4-diamido::CHEMBL253275::benzimidazole analog., 32 Matrix metalloproteinase-16 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2008.08.058 10.7270/Q2JD4WM2 18790648 Georgiadis, D; Yiotakis, A University of Athens http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26806&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 11294179 57298518 CHEMBL253275 ZINC13982474 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50432510 Cc1cc(COc2ccc(cc2)C(=O)NC2(CC(=O)NO)CCOCC2)c2ccccc2n1 InChI=1S/C25H27N3O5/c1-17-14-19(21-4-2-3-5-22(21)26-17)16-33-20-8-6-18(7-9-20)24(30)27-25(15-23(29)28-31)10-12-32-13-11-25/h2-9,14,31H,10-13,15-16H2,1H3,(H,27,30)(H,28,29) NUVSGXIVCJBRBF-UHFFFAOYSA-N 50183715 CHEMBL207305::N-(4-(2-(hydroxyamino)-2-oxoethyl)-tetrahydro-2H-pyran-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide::N-(4-(2-(hydroxyamino)-2-oxoethyl)tetrahydro-2H-pyran-4-yl)-4-((2-methylquinolin-4-yl)methoxy)benzamide Matrix metalloproteinase-16 Homo sapiens >5554 ChEMBL 10.1016/j.bmc.2008.08.058 10.7270/Q2JD4WM2 18790648 Georgiadis, D; Yiotakis, A University of Athens http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50183715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50183715&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 9868333 104068149 CHEMBL207305 ZINC03817205 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50460435 CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1 OCSMOTCMPXTDND-OUAUKWLOSA-N 50063917 (2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide::CHEMBL279785::cid_119031::marimastat Matrix metalloproteinase-16 Homo sapiens 10000 ChEMBL 10.1021/acs.jmedchem.5b01434 10.7270/Q20G3N0F 26653735 Ruminski, PG; Massa, M; Strohbach, J; Hanau, CE; Schmidt, M; Scholten, JA; Fletcher, TR; Hamper, BC; Carroll, JN; Shieh, HS; Caspers, N; Collins, B; Grapperhaus, M; Palmquist, KE; Collins, J; Baldus, JE; Hitchcock, J; Kleine, HP; Rogers, MD; McDonald, J; Munie, GE; Messing, DM; Portolan, S; Whiteley, LO; Sunyer, T; Schnute, ME Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50063917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50063917&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 097 1R55,3HY7,2JIH 119031 103959089 50662 CHEMBL279785 DB00786 5220 ZINC01544157 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50508408 CC(C)ON(CC(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C17H20N2O5S/c1-13(2)24-19(12-17(20)18-21)25(22,23)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13,21H,12H2,1-2H3,(H,18,20) PHGLPDURIUEELR-UHFFFAOYSA-N 50161331 2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-hydroxy-acetamide::CHEMBL181244::N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide Matrix metalloproteinase-16 Homo sapiens 900 ChEMBL 10.1021/jm900261f 10.7270/Q2JW8DXN 19606871 Nuti, E; Casalini, F; Avramova, SI; Santamaria, S; Cercignani, G; Marinelli, L; La Pietra, V; Novellino, E; Orlandini, E; Nencetti, S; Tuccinardi, T; Martinelli, A; Lim, NH; Visse, R; Nagase, H; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161331&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 10B 4H76,4H3X 10044321 104047647 CHEMBL181244 5140 ZINC03818628 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50508409 CC(C)ON(CC(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccc(OCc2ccc(Cl)cc2)cc1 InChI=1S/C24H25ClN2O6S/c1-17(2)33-27(15-24(28)26-29)34(30,31)23-13-7-20(8-14-23)19-5-11-22(12-6-19)32-16-18-3-9-21(25)10-4-18/h3-14,17,29H,15-16H2,1-2H3,(H,26,28) DKTYDWAJILHINP-UHFFFAOYSA-N 50294124 2-(4'-(4-Chlorobenzyloxy)-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxyacetamide::CHEMBL550350 Matrix metalloproteinase-16 Homo sapiens 15000 ChEMBL 10.1021/jm900261f 10.7270/Q2JW8DXN 19606871 Nuti, E; Casalini, F; Avramova, SI; Santamaria, S; Cercignani, G; Marinelli, L; La Pietra, V; Novellino, E; Orlandini, E; Nencetti, S; Tuccinardi, T; Martinelli, A; Lim, NH; Visse, R; Nagase, H; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294124&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44219901 104135675 CHEMBL550350 ZINC43013084 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50508410 CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccc(OCc2ccc(Cl)cc2)cc1 InChI=1S/C27H31ClN2O6S/c1-18(2)26(27(31)29-32)30(36-19(3)4)37(33,34)25-15-9-22(10-16-25)21-7-13-24(14-8-21)35-17-20-5-11-23(28)12-6-20/h5-16,18-19,26,32H,17H2,1-4H3,(H,29,31)/t26-/m1/s1 UTCUOTDVVXFCLJ-AREMUKBSSA-N 50294131 (R)-2-(4'-(4-Chlorobenzyloxy)-N-isopropoxybiphenyl-4-ylsulfonamido)-N-hydroxy-3-methylbutanamide::CHEMBL550548 Matrix metalloproteinase-16 Homo sapiens 5000 ChEMBL 10.1021/jm900261f 10.7270/Q2JW8DXN 19606871 Nuti, E; Casalini, F; Avramova, SI; Santamaria, S; Cercignani, G; Marinelli, L; La Pietra, V; Novellino, E; Orlandini, E; Nencetti, S; Tuccinardi, T; Martinelli, A; Lim, NH; Visse, R; Nagase, H; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294131&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44220093 104135682 CHEMBL550548 ZINC43018576 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50508411 CC(C)ON(C(C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccc(cc1)C(C)C InChI=1S/C23H32N2O5S/c1-15(2)18-7-9-19(10-8-18)20-11-13-21(14-12-20)31(28,29)25(30-17(5)6)22(16(3)4)23(26)24-27/h7-17,22,27H,1-6H3,(H,24,26) UMEYNLZNXJZVAP-UHFFFAOYSA-N 50294132 CHEMBL561963::N-hydroxy-2-(N-isopropoxy-4'-isopropylbiphenyl-4-ylsulfonamido)-3-methylbutanamide Matrix metalloproteinase-16 Homo sapiens 51 ChEMBL 10.1021/jm900261f 10.7270/Q2JW8DXN 19606871 Nuti, E; Casalini, F; Avramova, SI; Santamaria, S; Cercignani, G; Marinelli, L; La Pietra, V; Novellino, E; Orlandini, E; Nencetti, S; Tuccinardi, T; Martinelli, A; Lim, NH; Visse, R; Nagase, H; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50294132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50294132&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 45268787 104135683 CHEMBL561963 ZINC43075520 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531775 COc1ccc(Oc2ccc(cc2)S(=O)(=O)c2ccccc2CC(=O)NO)cc1 InChI=1S/C21H19NO6S/c1-27-16-6-8-17(9-7-16)28-18-10-12-19(13-11-18)29(25,26)20-5-3-2-4-15(20)14-21(23)22-24/h2-13,24H,14H2,1H3,(H,22,23) YOMXWXIANUYIMH-UHFFFAOYSA-N 50299051 CHEMBL573715::N-Hydroxy-2-{2-[4-(4-methoxy-phenoxy)benzenesulfonyl]-phenyl}acetamide Matrix metalloproteinase-16 Homo sapiens 32 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299051 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299051&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44247751 104140580 CHEMBL573715 ZINC45287050 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531791 CC(C)ON([C@H](C(C)C)C(O)=O)S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C20H25NO5S/c1-14(2)19(20(22)23)21(26-15(3)4)27(24,25)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19H,1-4H3,(H,22,23)/t19-/m1/s1 ABXUEPSHNXWTBZ-LJQANCHMSA-N 50299057 (R)-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanoic acid::CHEMBL575881 Matrix metalloproteinase-16 Homo sapiens 18000 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299057&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 45482676 104140586 CHEMBL575881 ZINC45289527 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531792 CC(C)ON([C@H](C(C)C)C(=O)NO)S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C20H26N2O5S/c1-14(2)19(20(23)21-24)22(27-15(3)4)28(25,26)18-12-10-17(11-13-18)16-8-6-5-7-9-16/h5-15,19,24H,1-4H3,(H,21,23)/t19-/m1/s1 DGZZVIWCMGVHGV-LJQANCHMSA-N 50161330 (R)-2-[(Biphenyl-4-sulfonyl)-isopropoxy-amino]-N-hydroxy-3-methyl-butyramide::(R)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide::CHEMBL179288 Matrix metalloproteinase-16 Homo sapiens 51 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161330&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 11292680 104047646 CHEMBL179288 ZINC13831240 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531818 COc1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO InChI=1S/C15H15NO5S/c1-21-12-6-8-13(9-7-12)22(19,20)14-5-3-2-4-11(14)10-15(17)16-18/h2-9,18H,10H2,1H3,(H,16,17) ITWGWXCEGHFMHT-UHFFFAOYSA-N 50299053 CHEMBL573714::N-Hydroxy-2-(2-(4-methoxyphenylsulfonyl)phenyl)acetamide Matrix metalloproteinase-16 Homo sapiens 130 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299053&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44478926 104140582 CHEMBL573714 ZINC45286734 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531819 COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)c1ccccc1CC(=O)NO InChI=1S/C21H19NO5S/c1-27-18-10-6-15(7-11-18)16-8-12-19(13-9-16)28(25,26)20-5-3-2-4-17(20)14-21(23)22-24/h2-13,24H,14H2,1H3,(H,22,23) DJZNIZCARKSSDE-UHFFFAOYSA-N 50299052 CHEMBL584365::N-Hydroxy-2-[2-(4'-methoxy-biphenyl-4-sulfonyl)phenyl]acetamide Matrix metalloproteinase-16 Homo sapiens 130 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299052&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search LPW 6ENM 44478927 104140581 CHEMBL584365 ZINC45321374 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531821 COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)c1ccccc1C(C)C(=O)NO InChI=1S/C22H21NO5S/c1-15(22(24)23-25)20-5-3-4-6-21(20)29(26,27)19-13-9-17(10-14-19)16-7-11-18(28-2)12-8-16/h3-15,25H,1-2H3,(H,23,24) ZCRWOWSOWBMWGI-UHFFFAOYSA-N 50299056 (+/-)-N-Hydroxy-2-[2-(4'-methoxy-biphenyl-4-sulfonyl)phenyl]propionamide::CHEMBL572780 Matrix metalloproteinase-16 Homo sapiens 150 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299056&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479197 104140585 CHEMBL572780 ZINC45288161 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531825 ONC(=O)Cc1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C20H17NO4S/c22-20(21-23)14-17-8-4-5-9-19(17)26(24,25)18-12-10-16(11-13-18)15-6-2-1-3-7-15/h1-13,23H,14H2,(H,21,22) YYBFXMXFWMJGLB-UHFFFAOYSA-N 50299054 2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-acetamide::CHEMBL574370 Matrix metalloproteinase-16 Homo sapiens 220 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299054&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479460 104140583 CHEMBL574370 ZINC45285274 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50548045 Cc1cc(cc(n1)C(=O)NCc1ccc(F)cc1)-c1nnn(C[C@H]2CC[C@@H](CC2)C(O)=O)n1 InChI=1S/C23H25FN6O3/c1-14-10-18(11-20(26-14)22(31)25-12-15-4-8-19(24)9-5-15)21-27-29-30(28-21)13-16-2-6-17(7-3-16)23(32)33/h4-5,8-11,16-17H,2-3,6-7,12-13H2,1H3,(H,25,31)(H,32,33)/t16-,17- KOTGODCEORJYIF-QAQDUYKDSA-N 50305842 CHEMBL603656::trans-4-((5-(2-(4-fluorobenzylcarbamoyl)-6-methylpyridin-4-yl)-2H-tetrazol-2-yl)methyl)cyclohexanecarboxylic acid Matrix metalloproteinase-16 Homo sapiens >25000 ChEMBL 10.1016/j.bmcl.2009.11.081 10.7270/Q2JS9QHB 20005097 Schnute, ME; O'Brien, PM; Nahra, J; Morris, M; Howard Roark, W; Hanau, CE; Ruminski, PG; Scholten, JA; Fletcher, TR; Hamper, BC; Carroll, JN; Patt, WC; Shieh, HS; Collins, B; Pavlovsky, AG; Palmquist, KE; Aston, KW; Hitchcock, J; Rogers, MD; McDonald, J; Johnson, AR; Munie, GE; Wittwer, AJ; Man, CF; Settle, SL; Nemirovskiy, O; Vickery, LE; Agawal, A; Dyer, RD; Sunyer, T Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50305842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50305842&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 25183768 104160203 CHEMBL603656 ZINC43203228 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531841 CC(C(=O)NO)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C21H19NO4S/c1-15(21(23)22-24)19-9-5-6-10-20(19)27(25,26)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15,24H,1H3,(H,22,23) CPUBMGYGVNFLPZ-UHFFFAOYSA-N 50299058 (+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]N-hydroxy-propionamide::CHEMBL574605 Matrix metalloproteinase-16 Homo sapiens 470 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299058&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479699 104140587 CHEMBL574605 ZINC45287118 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531850 COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)c1ccccc1CC(O)=O InChI=1S/C21H18O5S/c1-26-18-10-6-15(7-11-18)16-8-12-19(13-9-16)27(24,25)20-5-3-2-4-17(20)14-21(22)23/h2-13H,14H2,1H3,(H,22,23) FIPYOKGRSDJCAR-UHFFFAOYSA-N 50299055 CHEMBL573936::[2-(4'-Methoxy-biphenyl-4-sulfonyl)phenyl]acetic Acid Matrix metalloproteinase-16 Homo sapiens 730 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299055&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search BKW 6EOX 44479199 104140584 CHEMBL573936 ZINC45285873 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531858 COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)c1ccccc1C(C)C(O)=O InChI=1S/C22H20O5S/c1-15(22(23)24)20-5-3-4-6-21(20)28(25,26)19-13-9-17(10-14-19)16-7-11-18(27-2)12-8-16/h3-15H,1-2H3,(H,23,24) XORCBTCEBZUVES-UHFFFAOYSA-N 50299060 (+/-)-2-[2-(4'-Methoxy-biphenyl-4-sulfonyl)phenyl]propionic Acid::CHEMBL584147 Matrix metalloproteinase-16 Homo sapiens 1100 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299060&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479703 104140589 CHEMBL584147 ZINC45321352 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531861 COc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)c1ccccc1C(=O)NO InChI=1S/C20H17NO5S/c1-26-16-10-6-14(7-11-16)15-8-12-17(13-9-15)27(24,25)19-5-3-2-4-18(19)20(22)21-23/h2-13,23H,1H3,(H,21,22) OREDIHYKGISTDR-UHFFFAOYSA-N 50299059 CHEMBL573934::N-Hydroxy-2-(4'-methoxybiphenyl-4-ylsulfonyl)benzamide Matrix metalloproteinase-16 Homo sapiens 1200 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299059&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479459 104140588 CHEMBL573934 ZINC45285869 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531864 ONC(=O)c1ccccc1S(=O)(=O)c1ccc(Oc2ccccc2)cc1 InChI=1S/C19H15NO5S/c21-19(20-22)17-8-4-5-9-18(17)26(23,24)16-12-10-15(11-13-16)25-14-6-2-1-3-7-14/h1-13,22H,(H,20,21) MYZHQACPXTZCJY-UHFFFAOYSA-N 50299065 CHEMBL575896::N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide Matrix metalloproteinase-16 Homo sapiens 1300 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299065&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 10155934 104140594 CHEMBL575896 ZINC34337919 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531877 OC(=O)Cc1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C20H16O4S/c21-20(22)14-17-8-4-5-9-19(17)25(23,24)18-12-10-16(11-13-18)15-6-2-1-3-7-15/h1-13H,14H2,(H,21,22) HGICQEUHJFERNR-UHFFFAOYSA-N 50299061 CHEMBL573935::[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid Matrix metalloproteinase-16 Homo sapiens 4300 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299061&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479701 104140590 CHEMBL573935 ZINC45285871 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531879 ONC(=O)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C19H15NO4S/c21-19(20-22)17-8-4-5-9-18(17)25(23,24)16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13,22H,(H,20,21) WQRJSSRVHCJAKB-UHFFFAOYSA-N 50299064 2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide::CHEMBL574589 Matrix metalloproteinase-16 Homo sapiens 5100 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299064&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44478925 104140593 CHEMBL574589 ZINC45286537 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531883 COc1ccc(Oc2ccc(cc2)S(=O)(=O)c2ccccc2C(=O)NO)cc1 InChI=1S/C20H17NO6S/c1-26-14-6-8-15(9-7-14)27-16-10-12-17(13-11-16)28(24,25)19-5-3-2-4-18(19)20(22)21-23/h2-13,23H,1H3,(H,21,22) OAJUMLCSJOEUON-UHFFFAOYSA-N 50299063 CHEMBL584122::N-Hydroxy-2-[4-(4-methoxy-phenoxy)benzenesulfonyl]benzamide Matrix metalloproteinase-16 Homo sapiens 6000 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299063&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44478924 104140592 CHEMBL584122 ZINC45318044 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531884 CC(C(O)=O)c1ccccc1S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C21H18O4S/c1-15(21(22)23)19-9-5-6-10-20(19)26(24,25)18-13-11-17(12-14-18)16-7-3-2-4-8-16/h2-15H,1H3,(H,22,23) HSMGGAWDRKACFW-UHFFFAOYSA-N 50299067 (+/-)-2-[2-(Biphenyl-4-sulfonyl)phenyl]propionic Acid::CHEMBL579068 Matrix metalloproteinase-16 Homo sapiens 6300 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299067&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479702 104140596 CHEMBL579068 ZINC45301904 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531885 COc1ccc(Oc2ccc(cc2)S(=O)(=O)c2ccccc2CC(O)=O)cc1 InChI=1S/C21H18O6S/c1-26-16-6-8-17(9-7-16)27-18-10-12-19(13-11-18)28(24,25)20-5-3-2-4-15(20)14-21(22)23/h2-13H,14H2,1H3,(H,22,23) YMAXKJGQKQACFZ-UHFFFAOYSA-N 50299062 CHEMBL579067::{2-[4-(4-Methoxy-phenoxy)benzenesulfonyl]phenyl}acetic Acid Matrix metalloproteinase-16 Homo sapiens 6500 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299062&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479198 104140591 CHEMBL579067 ZINC45301900 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531909 COc1ccc(cc1)S(=O)(=O)c1ccccc1C(=O)NO InChI=1S/C14H13NO5S/c1-20-10-6-8-11(9-7-10)21(18,19)13-5-3-2-4-12(13)14(16)15-17/h2-9,17H,1H3,(H,15,16) QPFIKHZWPMXTRS-UHFFFAOYSA-N 50299068 CHEMBL575895::N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide Matrix metalloproteinase-16 Homo sapiens 31000 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299068&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479457 104140597 CHEMBL575895 ZINC45290825 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531923 COc1ccc(cc1)S(=O)(=O)c1ccccc1CC(O)=O InChI=1S/C15H14O5S/c1-20-12-6-8-13(9-7-12)21(18,19)14-5-3-2-4-11(14)10-15(16)17/h2-9H,10H2,1H3,(H,16,17) BZWDHUMJSSLVCR-UHFFFAOYSA-N 50299069 2-(2-(4-Methoxyphenylsulfonyl)phenyl)acetic Acid::CHEMBL585376 Matrix metalloproteinase-16 Homo sapiens 93000 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299069&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479700 104140598 CHEMBL585376 ZINC45319688 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50531924 CS(=O)c1ccc(Oc2ccc(cc2)S(=O)(=O)c2ccccc2C(=O)NO)cc1 InChI=1S/C20H17NO6S2/c1-28(24)16-10-6-14(7-11-16)27-15-8-12-17(13-9-15)29(25,26)19-5-3-2-4-18(19)20(22)21-23/h2-13,23H,1H3,(H,21,22) RPBGCJQDVJCGSK-UHFFFAOYSA-N 50299066 CHEMBL576762::N-Hydroxy-2-[4-(4-methanesulfinyl-phenoxy)-benzenesulfonyl]-benzamide Matrix metalloproteinase-16 Homo sapiens 110000 ChEMBL 10.1021/jm900335a 10.7270/Q2HQ3ZZS 19775099 Nuti, E; Panelli, L; Casalini, F; Avramova, SI; Orlandini, E; Santamaria, S; Nencetti, S; Tuccinardi, T; Martinelli, A; Cercignani, G; D'Amelio, N; Maiocchi, A; Uggeri, F; Rossello, A Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50299066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50299066&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44479458 104140595 CHEMBL576762 ZINC45300348 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50711766 COc1ccc(cc1)S(=O)(=O)N1CC(=O)N(O)C(=O)[C@H]1C(C)C InChI=1S/C14H18N2O6S/c1-9(2)13-14(18)16(19)12(17)8-15(13)23(20,21)11-6-4-10(22-3)5-7-11/h4-7,9,13,19H,8H2,1-3H3/t13-/m1/s1 FTRCUXMVUJZMHT-CYBMUJFWSA-N 50361599 CHEMBL1939844 Matrix metalloproteinase-16 Homo sapiens 1100 ChEMBL 10.1021/jm200593b 10.7270/Q2MP53QN 22017477 Marques, SM; Tuccinardi, T; Nuti, E; Santamaria, S; Andre, V; Rossello, A; Martinelli, A; Santos, MA Instituto Superior T£cnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361599&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 56835169 136965661 CHEMBL1939844 ZINC73157513 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50711767 CC(C)[C@H]1N(CC(=O)N(O)C1=O)S(=O)(=O)c1ccc(cc1)-c1ccccc1 InChI=1S/C19H20N2O5S/c1-13(2)18-19(23)21(24)17(22)12-20(18)27(25,26)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13,18,24H,12H2,1-2H3/t18-/m1/s1 JVBFGGAYMSJQBZ-GOSISDBHSA-N 50361600 CHEMBL1939845 Matrix metalloproteinase-16 Homo sapiens 2200 ChEMBL 10.1021/jm200593b 10.7270/Q2MP53QN 22017477 Marques, SM; Tuccinardi, T; Nuti, E; Santamaria, S; Andre, V; Rossello, A; Martinelli, A; Santos, MA Instituto Superior T£cnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361600&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 56835168 136965662 CHEMBL1939845 ZINC73165037 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50711768 CC(C)[C@H]1N(CC(=O)N(O)C1=O)S(=O)(=O)c1ccc(Oc2ccccc2)cc1 InChI=1S/C19H20N2O6S/c1-13(2)18-19(23)21(24)17(22)12-20(18)28(25,26)16-10-8-15(9-11-16)27-14-6-4-3-5-7-14/h3-11,13,18,24H,12H2,1-2H3/t18-/m1/s1 RQCBSNJRFVZHOS-GOSISDBHSA-N 50361601 CHEMBL1939846 Matrix metalloproteinase-16 Homo sapiens 39 ChEMBL 10.1021/jm200593b 10.7270/Q2MP53QN 22017477 Marques, SM; Tuccinardi, T; Nuti, E; Santamaria, S; Andre, V; Rossello, A; Martinelli, A; Santos, MA Instituto Superior T£cnico http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50361601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50361601&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 56835167 136965663 CHEMBL1939846 ZINC73221760 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50720538 C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 GDYIQUFNICPYHF-GOSISDBHSA-N 50365344 CHEMBL1956115 Matrix metalloproteinase-16 Homo sapiens >10000 ChEMBL 10.1021/jm2014748 10.7270/Q2VX0H0W 22175825 Brown, MF; Reilly, U; Abramite, JA; Arcari, JT; Oliver, R; Barham, RA; Che, Y; Chen, JM; Collantes, EM; Chung, SW; Desbonnet, C; Doty, J; Doroski, M; Engtrakul, JJ; Harris, TM; Huband, M; Knafels, JD; Leach, KL; Liu, S; Marfat, A; Marra, A; McElroy, E; Melnick, M; Menard, CA; Montgomery, JI; Mullins, L; Noe, MC; O'Donnell, J; Penzien, J; Plummer, MS; Price, LM; Shanmugasundaram, V; Thoma, C; Uccello, DP; Warmus, JS; Wishka, DG Pfizer Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50365344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50365344&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 51355576 136969406 CHEMBL1956115 ZINC73311685 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50801993 CNC(=O)CNC(=O)[C@@H]1Cc2ccc(OCCC[C@@H]([C@@H](CC(C)C)C(=O)N1)C(=O)NO)cc2 InChI=1S/C23H34N4O6/c1-14(2)11-18-17(22(30)27-32)5-4-10-33-16-8-6-15(7-9-16)12-19(26-21(18)29)23(31)25-13-20(28)24-3/h6-9,14,17-19,32H,4-5,10-13H2,1-3H3,(H,24,28)(H,25,31)(H,26,29)(H,27,30)/t17-,18+,19-/m0/s1 HFAGTNGCAZYYLZ-OTWHNJEPSA-N 50102594 7-Isobutyl-8-oxo-2-oxa-9-aza-bicyclo[10.2.2]hexadeca-1(15),12(16),13-triene-6,10-dicarboxylic acid 6-hydroxyamide 10-methylcarbamoylmethyl-amide(SL422)::CHEMBL88520 Matrix metalloproteinase-16 Homo sapiens 35 ChEMBL 10.1021/jm010127e 10.7270/Q2FB53NR 11472217 Xue, CB; Voss, ME; Nelson, DJ; Duan, JJ; Cherney, RJ; Jacobson, IC; He, X; Roderick, J; Chen, L; Corbett, RL; Wang, L; Meyer, DT; Kennedy, K; DeGradodagger, WF; Hardman, KD; Teleha, CA; Jaffee, BD; Liu, RQ; Copeland, RA; Covington, MB; Christ, DD; Trzaskos, JM; Newton, RC; Magolda, RL; Wexler, RR; Decicco, CP DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102594&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 10344307 103999108 CHEMBL88520 ZINC13863588 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 50802005 CC(C)C[C@@H]1[C@H](CCCOC(=O)NCCCC[C@H](NC1=O)C(=O)NCC(=O)N1CCOCC1)C(=O)NO InChI=1S/C24H41N5O8/c1-16(2)14-18-17(22(32)28-35)6-5-11-37-24(34)25-8-4-3-7-19(27-21(18)31)23(33)26-15-20(30)29-9-12-36-13-10-29/h16-19,35H,3-15H2,1-2H3,(H,25,34)(H,26,33)(H,27,31)(H,28,32)/t17-,18+,19-/m0/s1 DONMTDNLNMLOIC-OTWHNJEPSA-N 50102608 11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide]::11-Isobutyl-2,10-dioxo-1-oxa-3,9-diaza-cyclopentadecane-8,12-dicarboxylic acid 12-hydroxyamide 8-[(2-morpholin-4-yl-2-oxo-ethyl)-amide](SP057)::CHEMBL91636 Matrix metalloproteinase-16 Homo sapiens 107 ChEMBL 10.1021/jm010127e 10.7270/Q2FB53NR 11472217 Xue, CB; Voss, ME; Nelson, DJ; Duan, JJ; Cherney, RJ; Jacobson, IC; He, X; Roderick, J; Chen, L; Corbett, RL; Wang, L; Meyer, DT; Kennedy, K; DeGradodagger, WF; Hardman, KD; Teleha, CA; Jaffee, BD; Liu, RQ; Copeland, RA; Covington, MB; Christ, DD; Trzaskos, JM; Newton, RC; Magolda, RL; Wexler, RR; Decicco, CP DuPont Pharmaceuticals Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50102608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50102608&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 9936728 103999111 CHEMBL91636 ZINC03923778 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48 51469333 ONC(=O)C1N(CCc2cc(O)ccc12)S(=O)(=O)c1cc(Cl)ccc1Cl InChI=1S/C16H14Cl2N2O5S/c17-10-1-4-13(18)14(8-10)26(24,25)20-6-5-9-7-11(21)2-3-12(9)15(20)16(22)19-23/h1-4,7-8,15,21,23H,5-6H2,(H,19,22) QMIAXILIKVOPKK-UHFFFAOYSA-N 50137278 2-(2,5-Dichloro-benzenesulfonyl)-6-hydroxy-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acid hydroxyamide::2-(2,5-dichlorophenylsulfonyl)-N,6-dihydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxamide::CHEMBL424130 Matrix metalloproteinase-16 Homo sapiens 1839 ChEMBL 10.7270/Q2GB281X 35969157 Baidya, SK; Banerjee, S; Adhikari, N; Jha, T Jadavpur University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50137278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001170&target=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50137278&enzyme=Matrix+metalloproteinase-16&column=ki&startPg=0&Increment=50&submit=Search 44364266 104027444 CHEMBL424130 ZINC13588265 1 MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 1RM8 Matrix metalloproteinase-16 MMP16_HUMAN P51512 B2RAN7 Q14824 Q52H48