BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50120804 Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1 InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1 HLCHESOMJVGDSJ-LOYHVIPDSA-N 50119368 (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(3H-[1,2,4]triazol-1-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide::(R)-N-((R)-1-(4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::CHEMBL339053::THIQ Melanocortin receptor 4 Rattus norvegicus 0.600000 ChEMBL 10.1021/jm025539h 10.7270/Q2GT5MH9 12361385 Sebhat, IK; Martin, WJ; Ye, Z; Barakat, K; Mosley, RT; Johnston, DB; Bakshi, R; Palucki, B; Weinberg, DH; MacNeil, T; Kalyani, RN; Tang, R; Stearns, RA; Miller, RR; Tamvakopoulos, C; Strack, AM; McGowan, E; Cashen, DE; Drisko, JE; Hom, GJ; Howard, AD; MacIntyre, DE; van der Ploeg, LH; Patchett, AA; Nargund, RP Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50119368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50119368&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1I8 7F58 9938402 104012586 CHEMBL339053 ZINC36269777 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50129725 CN1C[C@H]2CC[C@@H]1[C@@H](C2)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C InChI=1S/C34H51FN4O3/c1-33(2,3)37-32(42)34(25-8-6-5-7-9-25)16-18-39(19-17-34)31(41)28(21-23-10-13-26(35)14-11-23)36-30(40)27-20-24-12-15-29(27)38(4)22-24/h10-11,13-14,24-25,27-29H,5-9,12,15-22H2,1-4H3,(H,36,40)(H,37,42)/t24-,27+,28+,29+/m0/s1 ARFBDECCXOFCBN-HOLBEBDISA-N 50169442 (1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide::CHEMBL364346 Melanocortin receptor 4 Rattus norvegicus 5000 ChEMBL 10.1016/j.bmcl.2005.05.109 10.7270/Q2Q81CKF 15982875 Ye, Z; Guo, L; Barakat, KJ; Pollard, PG; Palucki, BL; Sebhat, IK; Bakshi, RK; Tang, R; Kalyani, RN; Vongs, A; Chen, AS; Chen, HY; Rosenblum, CI; MacNeil, T; Weinberg, DH; Peng, Q; Tamvakopoulos, C; Miller, RR; Stearns, RA; Cashen, DE; Martin, WJ; Metzger, JM; Strack, AM; MacIntyre, DE; Van der Ploeg, LH; Patchett, AA; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169442&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 6918851 104054247 CHEMBL364346 1337 ZINC14209775 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50216036 Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1 InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1 HLCHESOMJVGDSJ-LOYHVIPDSA-N 50119368 (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(3H-[1,2,4]triazol-1-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide::(R)-N-((R)-1-(4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::CHEMBL339053::THIQ Melanocortin receptor 4 Rattus norvegicus 2.9 ChEMBL 10.1021/jm025539h 10.7270/Q2GT5MH9 12361385 Sebhat, IK; Martin, WJ; Ye, Z; Barakat, K; Mosley, RT; Johnston, DB; Bakshi, R; Palucki, B; Weinberg, DH; MacNeil, T; Kalyani, RN; Tang, R; Stearns, RA; Miller, RR; Tamvakopoulos, C; Strack, AM; McGowan, E; Cashen, DE; Drisko, JE; Hom, GJ; Howard, AD; MacIntyre, DE; van der Ploeg, LH; Patchett, AA; Nargund, RP Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50119368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50119368&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1I8 7F58 9938402 104012586 CHEMBL339053 ZINC36269777 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50209500 CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(Br)cc1F)C(C)(C)C InChI=1S/C31H40BrClFN3O2/c1-6-29(35-19(2)38)25-16-22(33)8-10-23(25)20-11-13-36(14-12-20)30(39)27-18-37(31(3,4)5)17-26(27)24-9-7-21(32)15-28(24)34/h7-10,15-16,20,26-27,29H,6,11-14,17-18H2,1-5H3,(H,35,38)/t26-,27+,29+/m1/s1 MIAUOPQGTJQSKK-XQFUHLNNSA-N 50373476 CHEMBL255286 Melanocortin receptor 4 Rattus norvegicus 10 ChEMBL 10.1016/j.bmcl.2008.04.049 10.7270/Q2W37X5S 18479920 Guo, L; Ye, Z; Ujjainwalla, F; Sings, HL; Sebhat, IK; Huber, J; Weinberg, DH; Tang, R; MacNeil, T; Tamvakopoulos, C; Peng, Q; MacIntyre, E; van der Ploeg, LH; Goulet, MT; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373476&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44448631 160852577 CHEMBL255286 ZINC29043282 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50209514 CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(Br)cc1F)C(C)(C)C InChI=1S/C31H40BrClFN3O2/c1-6-29(35-19(2)38)25-16-22(33)8-10-23(25)20-11-13-36(14-12-20)30(39)27-18-37(31(3,4)5)17-26(27)24-9-7-21(32)15-28(24)34/h7-10,15-16,20,26-27,29H,6,11-14,17-18H2,1-5H3,(H,35,38)/t26-,27+,29-/m0/s1 MIAUOPQGTJQSKK-GKRYNVPLSA-N 50373472 CHEMBL429854 Melanocortin receptor 4 Rattus norvegicus 1.7 ChEMBL 10.1016/j.bmcl.2008.04.049 10.7270/Q2W37X5S 18479920 Guo, L; Ye, Z; Ujjainwalla, F; Sings, HL; Sebhat, IK; Huber, J; Weinberg, DH; Tang, R; MacNeil, T; Tamvakopoulos, C; Peng, Q; MacIntyre, E; van der Ploeg, LH; Goulet, MT; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373472&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44448629 160852573 CHEMBL429854 ZINC29043278 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50306145 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(N)=O InChI=1S/C51H70N18O11S2/c1-27(70)62-33(13-7-17-58-50(53)54)43(74)69-40-25-82-81-24-39(42(52)73)68-47(78)37(20-29-22-60-32-12-6-5-11-31(29)32)66-44(75)34(14-8-18-59-51(55)56)63-46(77)36(19-28-9-3-2-4-10-28)65-48(79)38(21-30-23-57-26-61-30)67-45(76)35(64-49(40)80)15-16-41(71)72/h2-6,9-12,22-23,26,33-40,60H,7-8,13-21,24-25H2,1H3,(H2,52,73)(H,57,61)(H,62,70)(H,63,77)(H,64,80)(H,65,79)(H,66,75)(H,67,76)(H,68,78)(H,69,74)(H,71,72)(H4,53,54,58)(H4,55,56,59)/t33-,34+,35-,36+,37-,38+,39-,40-/m0/s1 UNXFCHHFXJFRRB-ABRXVHCYSA-N 50165936 Ac-dR[CEHdFRWC]-NH2::CHEMBL267900 Melanocortin receptor 4 Rattus norvegicus 0.390000 ChEMBL 10.1021/jm0501432 10.7270/Q2251HQZ 15857110 Mayer, JP; Hsiung, HM; Flora, DB; Edwards, P; Smith, DP; Zhang, XY; Gadski, RA; Heiman, ML; Hertel, JL; Emmerson, PJ; Husain, S; O'brien, TP; Kahl, SD; Smiley, DL; Zhang, L; Dimarchi, RD; Yan, LZ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165936&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44400402 104051399 CHEMBL267900 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50306156 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(O)=O InChI=1S/C90H127N25O26S/c1-47(2)74(87(139)100-43-73(125)126)113-86(138)68-21-13-31-114(68)88(140)59(18-9-10-29-91)102-70(120)42-99-76(128)62(36-50-40-98-55-17-8-7-16-53(50)55)108-77(129)56(19-11-30-97-90(94)95)103-80(132)60(34-48-14-5-4-6-15-48)106-82(134)63(37-51-41-96-46-101-51)109-78(130)57(26-27-71(121)122)104-79(131)58(28-33-142-3)105-83(135)65(44-116)111-81(133)61(35-49-22-24-52(118)25-23-49)107-84(136)66(45-117)112-85(137)67-20-12-32-115(67)89(141)64(39-72(123)124)110-75(127)54(92)38-69(93)119/h4-8,14-17,22-25,40-41,46-47,54,56-68,74,98,116-118H,9-13,18-21,26-39,42-45,91-92H2,1-3H3,(H2,93,119)(H,96,101)(H,99,128)(H,100,139)(H,102,120)(H,103,132)(H,104,131)(H,105,135)(H,106,134)(H,107,136)(H,108,129)(H,109,130)(H,110,127)(H,111,133)(H,112,137)(H,113,138)(H,121,122)(H,123,124)(H,125,126)(H4,94,95,97)/t54-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,74-/m0/s1 BUVGQEXSQXRZQG-LBQSHGEUSA-N 50165931 CHEMBL415165::NDP-SYSMEHFRWGKPVG Melanocortin receptor 4 Rattus norvegicus 0.090000 ChEMBL 10.1021/jm0501432 10.7270/Q2251HQZ 15857110 Mayer, JP; Hsiung, HM; Flora, DB; Edwards, P; Smith, DP; Zhang, XY; Gadski, RA; Heiman, ML; Hertel, JL; Emmerson, PJ; Husain, S; O'brien, TP; Kahl, SD; Smiley, DL; Zhang, L; Dimarchi, RD; Yan, LZ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165931&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91936745 104051394 CHEMBL415165 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50306171 CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]1CSSC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(N)=O InChI=1S/C60H79N19O13S2/c1-32(80)71-43(24-34-15-17-37(81)18-16-34)54(88)72-41(14-8-22-68-60(64)65)52(86)79-48-30-94-93-29-47(50(61)84)78-56(90)45(25-35-27-69-39-12-6-5-11-38(35)39)76-51(85)40(13-7-21-67-59(62)63)73-55(89)44(23-33-9-3-2-4-10-33)75-57(91)46(26-36-28-66-31-70-36)77-53(87)42(74-58(48)92)19-20-49(82)83/h2-6,9-12,15-18,27-28,31,40-48,69,81H,7-8,13-14,19-26,29-30H2,1H3,(H2,61,84)(H,66,70)(H,71,80)(H,72,88)(H,73,89)(H,74,92)(H,75,91)(H,76,85)(H,77,87)(H,78,90)(H,79,86)(H,82,83)(H4,62,63,67)(H4,64,65,68)/t40-,41-,42+,43-,44-,45+,46-,47+,48+/m0/s1 FEKXKTLLBDRSQH-XVRHLUALSA-N 50165930 Ac-YR[CEHdFRWC]-NH2::CHEMBL264352 Melanocortin receptor 4 Rattus norvegicus 0.520000 ChEMBL 10.1021/jm0501432 10.7270/Q2251HQZ 15857110 Mayer, JP; Hsiung, HM; Flora, DB; Edwards, P; Smith, DP; Zhang, XY; Gadski, RA; Heiman, ML; Hertel, JL; Emmerson, PJ; Husain, S; O'brien, TP; Kahl, SD; Smiley, DL; Zhang, L; Dimarchi, RD; Yan, LZ Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50165930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50165930&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44400370 104051393 CHEMBL264352 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50312139 CN1C[C@H]2CC[C@@H]1[C@@H](C2)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C InChI=1S/C34H51FN4O3/c1-33(2,3)37-32(42)34(25-8-6-5-7-9-25)16-18-39(19-17-34)31(41)28(21-23-10-13-26(35)14-11-23)36-30(40)27-20-24-12-15-29(27)38(4)22-24/h10-11,13-14,24-25,27-29H,5-9,12,15-22H2,1-4H3,(H,36,40)(H,37,42)/t24-,27+,28+,29+/m0/s1 ARFBDECCXOFCBN-HOLBEBDISA-N 50169442 (1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide::CHEMBL364346 Melanocortin receptor 4 Rattus norvegicus 3000 ChEMBL 10.1016/j.bmcl.2005.05.109 10.7270/Q2Q81CKF 15982875 Ye, Z; Guo, L; Barakat, KJ; Pollard, PG; Palucki, BL; Sebhat, IK; Bakshi, RK; Tang, R; Kalyani, RN; Vongs, A; Chen, AS; Chen, HY; Rosenblum, CI; MacNeil, T; Weinberg, DH; Peng, Q; Tamvakopoulos, C; Miller, RR; Stearns, RA; Cashen, DE; Martin, WJ; Metzger, JM; Strack, AM; MacIntyre, DE; Van der Ploeg, LH; Patchett, AA; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169442&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 6918851 104054247 CHEMBL364346 1337 ZINC14209775 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50389077 CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)N1CCCC1=O)C(F)(F)F InChI=1S/C29H36ClF3N4O2/c1-19(2)16-24(34)23-18-21(29(31,32)33)7-10-25(23)35-12-14-36(15-13-35)28(39)26(37-11-3-4-27(37)38)17-20-5-8-22(30)9-6-20/h5-10,18-19,24,26H,3-4,11-17,34H2,1-2H3/t24-,26+/m0/s1 GWQJQMUYAJRYAV-AZGAKELHSA-N 50214685 1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifluoromethylphenyl]-piperazin-1-yl}-1-(4-dichlorobenzyl)-2-oxoethyl]pyrrolidin-2-one::CHEMBL439560 Melanocortin receptor 4 Rattus norvegicus 9.1 ChEMBL 10.1016/j.bmc.2007.05.026 10.7270/Q2FF3S2P 17544282 Tran, JA; Tucci, FC; Jiang, W; Marinkovic, D; Chen, CW; Arellano, M; Markison, S; Fleck, BA; Wen, J; White, NS; Pontillo, J; Saunders, J; Marks, D; Hoare, SR; Madan, A; Foster, AC; Chen, C Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214685&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 23661656 104089632 CHEMBL439560 ZINC28825773 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50413190 CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1 InChI=1S/C29H40ClFN4O2/c1-20(2)27(32-26(36)13-14-33(4)5)24-7-6-8-25(31)28(24)34-15-17-35(18-16-34)29(37)21(3)19-22-9-11-23(30)12-10-22/h6-12,20-21,27H,13-19H2,1-5H3,(H,32,36)/t21-,27+/m1/s1 ROSDSGGMKIYLIM-ZBLYBZFDSA-N 50261195 1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine::CHEMBL497746 Melanocortin receptor 4 Rattus norvegicus 5.5 ChEMBL 10.1016/j.bmc.2008.03.072 10.7270/Q2TX3F54 18417348 Chen, C; Tucci, FC; Jiang, W; Tran, JA; Fleck, BA; Hoare, SR; Wen, J; Chen, T; Johns, M; Markison, S; Foster, AC; Marinkovic, D; Chen, CW; Arellano, M; Harman, J; Saunders, J; Bozigian, H; Marks, D Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261195&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44577060 104110404 CHEMBL497746 ZINC40975990 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50398221 CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)N1CCCC1=O InChI=1S/C30H40Cl2FN5O2/c1-20(2)17-26(35-11-10-34)23-5-3-6-25(33)29(23)36-13-15-37(16-14-36)30(40)27(38-12-4-7-28(38)39)18-21-8-9-22(31)19-24(21)32/h3,5-6,8-9,19-20,26-27,35H,4,7,10-18,34H2,1-2H3/t26-,27+/m0/s1 CGANDSYNDFLFKG-RRPNLBNLSA-N 50221120 1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methylbutyl)-6-fluorophenyl)piperazin-1-yl)-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl)pyrrolidin-2-one::CHEMBL393576::N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrrolidinyl)-3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-3-fluorophenyl)-3-methylbutyl]amine Melanocortin receptor 4 Rattus norvegicus 1 ChEMBL 10.1016/j.bmcl.2007.07.097 10.7270/Q2XK8F8V 17822895 Jiang, W; Tucci, FC; Tran, JA; Fleck, BA; Wen, J; Markison, S; Marinkovic, D; Chen, CW; Arellano, M; Hoare, SR; Johns, M; Foster, AC; Saunders, J; Chen, C Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50221120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50221120&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 24180646 104093809 CHEMBL393576 ZINC28823897 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50452168 Cc1cc(Cl)ccc1-c1cccc(COc2ccc(cc2)[C@H](CC(O)=O)c2nccn2C)c1 InChI=1S/C27H25ClN2O3/c1-18-14-22(28)8-11-24(18)21-5-3-4-19(15-21)17-33-23-9-6-20(7-10-23)25(16-26(31)32)27-29-12-13-30(27)2/h3-15,25H,16-17H2,1-2H3,(H,31,32)/t25-/m0/s1 GFFXCPIMXLSUGF-VWLOTQADSA-N 50019939 CHEMBL3287569 Melanocortin receptor 4 Rattus norvegicus 640 ChEMBL 10.1016/j.bmcl.2015.11.050 10.7270/Q21R6SBS 26620255 Ma, Z; Lin, DC; Sharma, R; Liu, J; Zhu, L; Li, AR; Kohn, T; Wang, Y; Liu, JJ; Bartberger, MD; Medina, JC; Zhuang, R; Li, F; Zhang, J; Luo, J; Wong, S; Tonn, GR; Houze, JB Amgen Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019939&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11961321 103930862 CHEMBL3287569 ZINC29485476 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50568323 CC(=O)NC(C)(C)[C@@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 InChI=1S/C34H44ClF2N3O2/c1-20-14-24-27(16-29(20)35)34(17-28(24)33(6,7)38-21(2)41)10-12-39(13-11-34)31(42)26-19-40(32(3,4)5)18-25(26)23-9-8-22(36)15-30(23)37/h8-9,14-16,25-26,28H,10-13,17-19H2,1-7H3,(H,38,41)/t25-,26+,28+/m0/s1 KMNARKQYUZICHM-ZRRKCSAHSA-N 50314764 CHEMBL1093304::trans-N-(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)propan-2-yl)acetamide Melanocortin receptor 4 Rattus norvegicus 2 ChEMBL 10.1016/j.bmcl.2010.02.058 10.7270/Q2QC03NP 20207541 He, S; Ye, Z; Dobbelaar, PH; Sebhat, IK; Guo, L; Liu, J; Jian, T; Lai, Y; Franklin, CL; Bakshi, RK; Dellureficio, JP; Hong, Q; Tsou, NN; Ball, RG; Cashen, DE; Martin, WJ; Weinberg, DH; Macneil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Miller, RR; Stearns, RA; Chen, HY; Chen, AS; Strack, AM; Fong, TM; Macintyre, DE; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314764&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11753695 104149125 CHEMBL1093304 ZINC49781164 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50588235 Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)C#N InChI=1S/C33H38ClF2N3O3/c1-20-14-24-27(16-28(20)34)33(42-30(24)32(2,3)19-37)8-10-38(11-9-33)31(40)26-18-39(22-6-12-41-13-7-22)17-25(26)23-5-4-21(35)15-29(23)36/h4-5,14-16,22,25-26,30H,6-13,17-18H2,1-3H3/t25-,26+,30-/m0/s1 BCFFSQJVHOEAAU-MWSYKCOMSA-N 50323441 2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile::CHEMBL1209788 Melanocortin receptor 4 Rattus norvegicus 1.1 ChEMBL 10.1016/j.bmcl.2010.06.068 10.7270/Q2TB172P 20621473 Guo, L; Ye, Z; Liu, J; He, S; Bakshi, RK; Sebhat, IK; Dobbelaar, PH; Hong, Q; Jian, T; Dellureficio, JP; Tsou, NN; Ball, RG; Weinberg, DH; MacNeil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Chen, HY; Chen, AS; Martin, WJ; MacIntyre, DE; Strack, AM; Fong, TM; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323441&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46919520 117644762 CHEMBL1209788 ZINC58582788 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50859672 CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C InChI=1S/C31H40Cl2FN3O2/c1-6-29(35-19(2)38)25-15-21(32)7-9-23(25)20-11-13-36(14-12-20)30(39)27-18-37(31(3,4)5)17-26(27)24-10-8-22(33)16-28(24)34/h7-10,15-16,20,26-27,29H,6,11-14,17-18H2,1-5H3,(H,35,38)/t26-,27+,29-/m0/s1 PWADIMGJQZHREF-GKRYNVPLSA-N 50373487 CHEMBL254589 Melanocortin receptor 4 Rattus norvegicus 0.900000 ChEMBL 10.1016/j.bmcl.2008.04.049 10.7270/Q2W37X5S 18479920 Guo, L; Ye, Z; Ujjainwalla, F; Sings, HL; Sebhat, IK; Huber, J; Weinberg, DH; Tang, R; MacNeil, T; Tamvakopoulos, C; Peng, Q; MacIntyre, E; van der Ploeg, LH; Goulet, MT; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373487&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44448660 160852588 CHEMBL254589 ZINC29043364 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50859682 CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(cc1)C(F)(F)F)C(C)(C)C InChI=1S/C32H41ClF3N3O2/c1-6-29(37-20(2)40)26-17-24(33)11-12-25(26)22-13-15-38(16-14-22)30(41)28-19-39(31(3,4)5)18-27(28)21-7-9-23(10-8-21)32(34,35)36/h7-12,17,22,27-29H,6,13-16,18-19H2,1-5H3,(H,37,40)/t27-,28+,29+/m1/s1 PNFDTYPRKXTXAO-ULNSLHSMSA-N 50373474 CHEMBL402769 Melanocortin receptor 4 Rattus norvegicus 1 ChEMBL 10.1016/j.bmcl.2008.04.049 10.7270/Q2W37X5S 18479920 Guo, L; Ye, Z; Ujjainwalla, F; Sings, HL; Sebhat, IK; Huber, J; Weinberg, DH; Tang, R; MacNeil, T; Tamvakopoulos, C; Peng, Q; MacIntyre, E; van der Ploeg, LH; Goulet, MT; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373474&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 24857886 160852575 CHEMBL402769 ZINC29043005 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50859683 CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(Br)cc1F)C(C)(C)C InChI=1S/C31H40BrClFN3O2/c1-6-29(35-19(2)38)25-16-22(33)8-10-23(25)20-11-13-36(14-12-20)30(39)27-18-37(31(3,4)5)17-26(27)24-9-7-21(32)15-28(24)34/h7-10,15-16,20,26-27,29H,6,11-14,17-18H2,1-5H3,(H,35,38)/t26-,27+,29+/m1/s1 MIAUOPQGTJQSKK-XQFUHLNNSA-N 50373476 CHEMBL255286 Melanocortin receptor 4 Rattus norvegicus 1.5 ChEMBL 10.1016/j.bmcl.2008.04.049 10.7270/Q2W37X5S 18479920 Guo, L; Ye, Z; Ujjainwalla, F; Sings, HL; Sebhat, IK; Huber, J; Weinberg, DH; Tang, R; MacNeil, T; Tamvakopoulos, C; Peng, Q; MacIntyre, E; van der Ploeg, LH; Goulet, MT; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373476&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44448631 160852577 CHEMBL255286 ZINC29043282 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50859684 CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@H]1CN(C[C@@H]1c1ccc(Cl)cc1Cl)C(C)(C)C InChI=1S/C31H40Cl3N3O2/c1-6-29(35-19(2)38)25-15-21(32)7-9-23(25)20-11-13-36(14-12-20)30(39)27-18-37(31(3,4)5)17-26(27)24-10-8-22(33)16-28(24)34/h7-10,15-16,20,26-27,29H,6,11-14,17-18H2,1-5H3,(H,35,38)/t26-,27+,29+/m1/s1 AZYLFDYQQJPDQC-XQFUHLNNSA-N 50373479 CHEMBL254757 Melanocortin receptor 4 Rattus norvegicus 0.500000 ChEMBL 10.1016/j.bmcl.2008.04.049 10.7270/Q2W37X5S 18479920 Guo, L; Ye, Z; Ujjainwalla, F; Sings, HL; Sebhat, IK; Huber, J; Weinberg, DH; Tang, R; MacNeil, T; Tamvakopoulos, C; Peng, Q; MacIntyre, E; van der Ploeg, LH; Goulet, MT; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373479&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16725559 160852580 CHEMBL254757 ZINC29043544 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50859691 CC[C@H](NC(C)=O)c1cc(Cl)ccc1C1CCN(CC1)C(=O)[C@@H]1CN(C[C@H]1c1ccc(Br)cc1F)C(C)(C)C InChI=1S/C31H40BrClFN3O2/c1-6-29(35-19(2)38)25-16-22(33)8-10-23(25)20-11-13-36(14-12-20)30(39)27-18-37(31(3,4)5)17-26(27)24-9-7-21(32)15-28(24)34/h7-10,15-16,20,26-27,29H,6,11-14,17-18H2,1-5H3,(H,35,38)/t26-,27+,29-/m0/s1 MIAUOPQGTJQSKK-GKRYNVPLSA-N 50373472 CHEMBL429854 Melanocortin receptor 4 Rattus norvegicus 0.500000 ChEMBL 10.1016/j.bmcl.2008.04.049 10.7270/Q2W37X5S 18479920 Guo, L; Ye, Z; Ujjainwalla, F; Sings, HL; Sebhat, IK; Huber, J; Weinberg, DH; Tang, R; MacNeil, T; Tamvakopoulos, C; Peng, Q; MacIntyre, E; van der Ploeg, LH; Goulet, MT; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50373472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50373472&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44448629 160852573 CHEMBL429854 ZINC29043278 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50527852 Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 InChI=1S/C29H32O7S/c1-19-12-25(34-10-5-11-37(3,32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24/h4,6-9,12-14,16,23H,5,10-11,15,17-18H2,1-3H3,(H,30,31)/t23-/m1/s1 BZCALJIHZVNMGJ-HSZRJFAPSA-N 50386790 CHEMBL1829174::CHEMBL2047159::TAK-875 Melanocortin receptor 4 Rattus norvegicus 27000 ChEMBL 10.1021/acsmedchemlett.6b00331 10.7270/Q2K35WN3 27994752 Agarwal, S; Sasane, S; Deshmukh, P; Rami, B; Bandyopadhyay, D; Giri, P; Giri, S; Jain, M; Desai, RC Cadila Healthcare Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386790&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 2YB 4PHU 24857286 160865873 CHEMBL2047159CHEMBL1829174 ZINC68208039 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50527867 [Ca++].CC#C[C@@H](CC([O-])=O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1.CC#C[C@@H](CC([O-])=O)c1ccc(OCc2cccc(CN(Cc3ccsc3)C(C)C)c2)cc1 InChI=1S/2C28H31NO3S.Ca/c2*1-4-6-26(16-28(30)31)25-9-11-27(12-10-25)32-19-23-8-5-7-22(15-23)17-29(21(2)3)18-24-13-14-33-20-24;/h2*5,7-15,20-21,26H,16-19H2,1-3H3,(H,30,31);/q;;+2/p-2/t2*26-;/m00./s1 KESURFVSLTYXJD-FKMBXMNYSA-L 50201670 CHEMBL3930086 Melanocortin receptor 4 Rattus norvegicus 20000 ChEMBL 10.1021/acsmedchemlett.6b00331 10.7270/Q2K35WN3 27994752 Agarwal, S; Sasane, S; Deshmukh, P; Rami, B; Bandyopadhyay, D; Giri, P; Giri, S; Jain, M; Desai, RC Cadila Healthcare Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50201670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50201670&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134137873 375979446 CHEMBL3930086 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50770065 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2c(C)cccc2C)cc1 InChI=1S/C27H25N3O3/c1-4-6-22(15-25(31)32)21-10-12-23(13-11-21)33-17-20-9-14-24-28-27(29-30(24)16-20)26-18(2)7-5-8-19(26)3/h5,7-14,16,22H,15,17H2,1-3H3,(H,31,32)/t22-/m0/s1 FDIWCHYTKOPHPS-QFIPXVFZSA-N 50204020 CHEMBL3927519 Melanocortin receptor 4 Rattus norvegicus 14 ChEMBL 10.1021/acs.jmedchem.7b01411 10.7270/Q2CZ39K5 29236497 Hamdouchi, C; Maiti, P; Warshawsky, AM; DeBaillie, AC; Otto, KA; Wilbur, KL; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Cr, S; Lineswala, JP; Neathery, GL; Bouaichi, C; Diseroad, BA; Campbell, AN; Sweetana, SA; Adams, LA; Cabrera, O; Ma, X; Yumibe, NP; Montrose-Rafizadeh, C; Chen, Y; Miller, AR Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50204020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50204020&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91809187 375980285 CHEMBL3927519 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50770069 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2ccc(cc2)C(C)C)cc1 InChI=1S/C28H27N3O3/c1-4-5-24(16-27(32)33)22-11-13-25(14-12-22)34-18-20-6-15-26-29-28(30-31(26)17-20)23-9-7-21(8-10-23)19(2)3/h6-15,17,19,24H,16,18H2,1-3H3,(H,32,33)/t24-/m0/s1 AUGDZUDMRWARAQ-DEOSSOPVSA-N 50247166 CHEMBL4082711 Melanocortin receptor 4 Rattus norvegicus 30 ChEMBL 10.1021/acs.jmedchem.7b01411 10.7270/Q2CZ39K5 29236497 Hamdouchi, C; Maiti, P; Warshawsky, AM; DeBaillie, AC; Otto, KA; Wilbur, KL; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Cr, S; Lineswala, JP; Neathery, GL; Bouaichi, C; Diseroad, BA; Campbell, AN; Sweetana, SA; Adams, LA; Cabrera, O; Ma, X; Yumibe, NP; Montrose-Rafizadeh, C; Chen, Y; Miller, AR Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247166&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118129999 401960754 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50770071 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2ccc(OCCC(C)(C)O)cc2)cc1 InChI=1S/C30H31N3O5/c1-4-5-24(18-28(34)35)22-7-11-26(12-8-22)38-20-21-6-15-27-31-29(32-33(27)19-21)23-9-13-25(14-10-23)37-17-16-30(2,3)36/h6-15,19,24,36H,16-18,20H2,1-3H3,(H,34,35)/t24-/m0/s1 QEFMCNSQIDKPRX-DEOSSOPVSA-N 50247156 CHEMBL4101472 Melanocortin receptor 4 Rattus norvegicus 68 ChEMBL 10.1021/acs.jmedchem.7b01411 10.7270/Q2CZ39K5 29236497 Hamdouchi, C; Maiti, P; Warshawsky, AM; DeBaillie, AC; Otto, KA; Wilbur, KL; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Cr, S; Lineswala, JP; Neathery, GL; Bouaichi, C; Diseroad, BA; Campbell, AN; Sweetana, SA; Adams, LA; Cabrera, O; Ma, X; Yumibe, NP; Montrose-Rafizadeh, C; Chen, Y; Miller, AR Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247156&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118129981 401960749 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50770072 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2c(C)cc(OCCCS(C)(=O)=O)cc2C)cc1 InChI=1S/C31H33N3O6S/c1-5-7-25(18-29(35)36)24-9-11-26(12-10-24)40-20-23-8-13-28-32-31(33-34(28)19-23)30-21(2)16-27(17-22(30)3)39-14-6-15-41(4,37)38/h8-13,16-17,19,25H,6,14-15,18,20H2,1-4H3,(H,35,36)/t25-/m0/s1 ZJTPBBJGTXYTGN-VWLOTQADSA-N 50247162 CHEMBL4075819 Melanocortin receptor 4 Rattus norvegicus 95 ChEMBL 10.1021/acs.jmedchem.7b01411 10.7270/Q2CZ39K5 29236497 Hamdouchi, C; Maiti, P; Warshawsky, AM; DeBaillie, AC; Otto, KA; Wilbur, KL; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Cr, S; Lineswala, JP; Neathery, GL; Bouaichi, C; Diseroad, BA; Campbell, AN; Sweetana, SA; Adams, LA; Cabrera, O; Ma, X; Yumibe, NP; Montrose-Rafizadeh, C; Chen, Y; Miller, AR Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247162&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118129974 401960750 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50770073 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2ccc(OC(F)F)cc2)cc1 InChI=1S/C26H21F2N3O4/c1-2-3-20(14-24(32)33)18-5-9-21(10-6-18)34-16-17-4-13-23-29-25(30-31(23)15-17)19-7-11-22(12-8-19)35-26(27)28/h4-13,15,20,26H,14,16H2,1H3,(H,32,33)/t20-/m0/s1 HBAPOFLCQDSXTE-FQEVSTJZSA-N 50247167 CHEMBL4097527 Melanocortin receptor 4 Rattus norvegicus 98 ChEMBL 10.1021/acs.jmedchem.7b01411 10.7270/Q2CZ39K5 29236497 Hamdouchi, C; Maiti, P; Warshawsky, AM; DeBaillie, AC; Otto, KA; Wilbur, KL; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Cr, S; Lineswala, JP; Neathery, GL; Bouaichi, C; Diseroad, BA; Campbell, AN; Sweetana, SA; Adams, LA; Cabrera, O; Ma, X; Yumibe, NP; Montrose-Rafizadeh, C; Chen, Y; Miller, AR Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247167&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118151370 401960755 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50770089 COCCOc1ccc(cc1)-c1nc2ccc(COc3ccc(cc3)[C@H](CC(O)=O)C#CC)cn2n1 InChI=1S/C28H27N3O5/c1-3-4-23(17-27(32)33)21-6-10-25(11-7-21)36-19-20-5-14-26-29-28(30-31(26)18-20)22-8-12-24(13-9-22)35-16-15-34-2/h5-14,18,23H,15-17,19H2,1-2H3,(H,32,33)/t23-/m0/s1 GMLOQFPUTGGMQW-QHCPKHFHSA-N 50247165 CHEMBL4077366 Melanocortin receptor 4 Rattus norvegicus 562 ChEMBL 10.1021/acs.jmedchem.7b01411 10.7270/Q2CZ39K5 29236497 Hamdouchi, C; Maiti, P; Warshawsky, AM; DeBaillie, AC; Otto, KA; Wilbur, KL; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Cr, S; Lineswala, JP; Neathery, GL; Bouaichi, C; Diseroad, BA; Campbell, AN; Sweetana, SA; Adams, LA; Cabrera, O; Ma, X; Yumibe, NP; Montrose-Rafizadeh, C; Chen, Y; Miller, AR Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247165&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118129998 401960753 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 50770090 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3nc(nn3c2)-c2ccc(cc2)C#N)cc1 InChI=1S/C26H20N4O3/c1-2-3-22(14-25(31)32)20-9-11-23(12-10-20)33-17-19-6-13-24-28-26(29-30(24)16-19)21-7-4-18(15-27)5-8-21/h4-13,16,22H,14,17H2,1H3,(H,31,32)/t22-/m0/s1 RBQKELFVIZDWRC-QFIPXVFZSA-N 50247163 CHEMBL4059614 Melanocortin receptor 4 Rattus norvegicus 216 ChEMBL 10.1021/acs.jmedchem.7b01411 10.7270/Q2CZ39K5 29236497 Hamdouchi, C; Maiti, P; Warshawsky, AM; DeBaillie, AC; Otto, KA; Wilbur, KL; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Cr, S; Lineswala, JP; Neathery, GL; Bouaichi, C; Diseroad, BA; Campbell, AN; Sweetana, SA; Adams, LA; Cabrera, O; Ma, X; Yumibe, NP; Montrose-Rafizadeh, C; Chen, Y; Miller, AR Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50247163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50247163&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118129979 401960751 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 784729 C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1F)C(O)=O InChI=1S/C30H38ClF2N3O3/c1-18-6-7-20(25(32)12-18)13-27(29(38)39)34-10-11-36(19(2)15-34)28(37)24-17-35(30(3,4)5)16-23(24)22-9-8-21(31)14-26(22)33/h6-9,12,14,19,23-24,27H,10-11,13,15-17H2,1-5H3,(H,38,39)/t19-,23-,24+,27-/m0/s1 NSIPBHNJNZCBMA-UAUZMGQXSA-N 392656 US10301286, Example 4 Melanocortin receptor 4 Rattus norvegicus 1.30 US Patent 10.7270/Q2833VCJ aid1798899 US10301286 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Astellas Pharma Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392656&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134583839 404960984 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 784730 C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2CCCc2c1)C(O)=O InChI=1S/C32H41F2N3O3/c1-20-17-35(29(31(39)40)15-21-8-9-22-6-5-7-23(22)14-21)12-13-37(20)30(38)27-19-36(32(2,3)4)18-26(27)25-11-10-24(33)16-28(25)34/h8-11,14,16,20,26-27,29H,5-7,12-13,15,17-19H2,1-4H3,(H,39,40)/t20-,26-,27+,29-/m0/s1 FTQFOEKMFLMGME-JXWHJRSQSA-N 392657 US10301286, Example 5 Melanocortin receptor 4 Rattus norvegicus 26.0 US Patent 10.7270/Q2833VCJ aid1798899 US10301286 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Astellas Pharma Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392657&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134583833 404960985 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 784731 CCC[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(F)cc1F)C(C)(C)C)[C@@H](Cc1ccc2ccccc2c1)C(O)=O InChI=1S/C35H43F2N3O3/c1-5-8-27-20-38(32(34(42)43)18-23-11-12-24-9-6-7-10-25(24)17-23)15-16-40(27)33(41)30-22-39(35(2,3)4)21-29(30)28-14-13-26(36)19-31(28)37/h6-7,9-14,17,19,27,29-30,32H,5,8,15-16,18,20-22H2,1-4H3,(H,42,43)/t27-,29-,30+,32-/m0/s1 FPSKGXUIOROROW-UMGNPTPLSA-N 392658 US10301286, Example 9 Melanocortin receptor 4 Rattus norvegicus 2.60 US Patent 10.7270/Q2833VCJ aid1798899 US10301286 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Astellas Pharma Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392658&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134583899 404960986 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 784732 C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1ccc(C)cc1)C(O)=O InChI=1S/C30H39ClFN3O3/c1-19-6-8-21(9-7-19)14-27(29(37)38)33-12-13-35(20(2)16-33)28(36)25-18-34(30(3,4)5)17-24(25)23-11-10-22(31)15-26(23)32/h6-11,15,20,24-25,27H,12-14,16-18H2,1-5H3,(H,37,38)/t20-,24-,25+,27-/m0/s1 FKQOUTBMWUASHL-NIXYAPBQSA-N 392659 US10301286, Example 11 Melanocortin receptor 4 Rattus norvegicus 21.0 US Patent 10.7270/Q2833VCJ aid1798899 US10301286 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Astellas Pharma Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392659&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134583809 404960987 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 784733 C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(F)cc(C)cc1F)C(O)=O InChI=1S/C30H37ClF3N3O3/c1-17-10-24(32)21(25(33)11-17)13-27(29(39)40)35-8-9-37(18(2)14-35)28(38)23-16-36(30(3,4)5)15-22(23)20-7-6-19(31)12-26(20)34/h6-7,10-12,18,22-23,27H,8-9,13-16H2,1-5H3,(H,39,40)/t18-,22-,23+,27-/m0/s1 GNDOGBVCQLMCPW-MAUNHCGISA-N 392660 US10301286, Example 76 Melanocortin receptor 4 Rattus norvegicus 1.70 US Patent 10.7270/Q2833VCJ aid1798899 US10301286 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Astellas Pharma Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392660&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 138659797 404960988 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 784734 C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1ccc(C)cc1F)C(O)=O InChI=1S/C31H38ClF2N3O4/c1-19-3-4-21(27(33)13-19)14-29(31(39)40)35-9-10-37(20(2)16-35)30(38)26-18-36(23-7-11-41-12-8-23)17-25(26)24-6-5-22(32)15-28(24)34/h3-6,13,15,20,23,25-26,29H,7-12,14,16-18H2,1-2H3,(H,39,40)/t20-,25-,26+,29-/m0/s1 PZRIXOAEIPPDAC-PJBRVGGZSA-N 392661 US10301286, Example 87 Melanocortin receptor 4 Rattus norvegicus 21.0 US Patent 10.7270/Q2833VCJ aid1798899 US10301286 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Astellas Pharma Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392661&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134583828 404960989 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 784735 C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C1CCOCC1)[C@@H](Cc1c(C)cc(C)cc1F)C(O)=O InChI=1S/C32H40ClF2N3O4/c1-19-12-20(2)25(28(34)13-19)15-30(32(40)41)36-8-9-38(21(3)16-36)31(39)27-18-37(23-6-10-42-11-7-23)17-26(27)24-5-4-22(33)14-29(24)35/h4-5,12-14,21,23,26-27,30H,6-11,15-18H2,1-3H3,(H,40,41)/t21-,26-,27+,30-/m0/s1 SDHWYNKMRJOEAU-NWAHNDBCSA-N 392662 US10301286, Example 88 Melanocortin receptor 4 Rattus norvegicus 11.0 US Patent 10.7270/Q2833VCJ aid1798899 US10301286 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Astellas Pharma Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392662&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134583805 404960990 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 784736 C[C@H]1CN(CCN1C(=O)[C@@H]1CN(C[C@H]1c1ccc(Cl)cc1F)C(C)(C)C)[C@@H](Cc1c(C)cc(C)cc1C)C(O)=O InChI=1S/C32H43ClFN3O3/c1-19-12-20(2)25(21(3)13-19)15-29(31(39)40)35-10-11-37(22(4)16-35)30(38)27-18-36(32(5,6)7)17-26(27)24-9-8-23(33)14-28(24)34/h8-9,12-14,22,26-27,29H,10-11,15-18H2,1-7H3,(H,39,40)/t22-,26-,27+,29-/m0/s1 ADUOPKMZFRVUSL-NNNZQYNTSA-N 392663 US10301286, Example 89 Melanocortin receptor 4 Rattus norvegicus 3.10 US Patent 10.7270/Q2833VCJ aid1798899 US10301286 Sugane, T; Makino, T; Yamashita, D; Yonetoku, Y; Tanabe, D; Mihara, H; Asai, N; Osoda, K; Shimizu, T; Moritomo, H; Sugasawa, K; Maeno, K; Hosogai, N Astellas Pharma Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=392663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=392663&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134583844 404960991 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110471 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(N4CCCCC4C)c3c2)cc1 294016 1-(5-((4-((2S)-1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-2-methylpiperidine::US10106553, Compound 48 Melanocortin receptor 4 Rattus norvegicus 21 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294016&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986250 381617132 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110493 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C)c3c2)cc1 293969 (2S)-5-(2-(4-((3-(2- Methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3-yn- 1-yl)-1H-tetrazole::US10106553, Compound 1 Melanocortin receptor 4 Rattus norvegicus 7.0 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293969&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986294 381617085 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110494 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C)c(-c4ccccc4C)c3c2)cc1 293987 5-((2S)-2-(4-((2-Methyl-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- ynyl)-1H-tetrazole::US10106553, Compound 19 Melanocortin receptor 4 Rattus norvegicus 10.0 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293987&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986401 381617103 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110495 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(F)c(-c4ccccc4C)c3c2)cc1 293971 5-((2S)-2-(4-((2-Fluoro-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- ynyl)-1H-tetrazole::US10106553, Compound 3 Melanocortin receptor 4 Rattus norvegicus 14 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293971&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986072 381617087 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110496 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Cl)c(-c4ccccc4C)c3c2)cc1 293970 5-((2S)-2-(4-((2-Chloro-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- ynyl)-1H-tetrazole::US10106553, Compound 2 Melanocortin receptor 4 Rattus norvegicus 20 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293970&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986050 381617086 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110497 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(I)c(-c4ccccc4C)c3c2)cc1 294003 5-((2S)-2-(4-((2-Iodo-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- ynyl)-1H-tetrazole::US10106553, Compound 35 Melanocortin receptor 4 Rattus norvegicus 33 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294003&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986113 381617119 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110498 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(C#N)c(-c4ccccc4C)c3c2)cc1 294006 5-((2S)-2-(4-((2-Cyano-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 38 Melanocortin receptor 4 Rattus norvegicus 19 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294006&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986051 381617122 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110499 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(c(-c4ccccc4C)c3c2)S(C)(=O)=O)cc1 294007 (2S)-5-(2-(4-((2- (Methylsulfonyl)-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 39 Melanocortin receptor 4 Rattus norvegicus 128 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294007&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986090 381617123 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110500 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(F)c3scc(-c4ccccc4C)c3c2)cc1 294037 (2S)-5-(2-(4-((7-Fluoro-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 69 Melanocortin receptor 4 Rattus norvegicus 30 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294037&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137529001 381617153 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110501 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(Cl)c3scc(-c4ccccc4C)c3c2)cc1 294035 (2S)-5-(2-(4-((7-Chloro-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 67 Melanocortin receptor 4 Rattus norvegicus 108 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294035&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137528999 381617151 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110502 COc1ccc(-c2csc3c(Cl)cc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1 294036 (2S)-5-(2-(4-((7-Chloro-3-(4- methoxy-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 68 Melanocortin receptor 4 Rattus norvegicus 71 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294036&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137529000 381617152 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110503 COCCOc1cccc(-c2csc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c1C 293978 (2S)-5-(2-(4-((3-(3-(2- Methoxyethoxy)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 10 Melanocortin receptor 4 Rattus norvegicus 14 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293978&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986112 381617094 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110504 COCCOc1ccc(C)c(c1)-c1csc2ccc(COc3ccc(cc3)[C@H](Cc3nnn[nH]3)C#CC)cc12 293983 (2S)-5-(2-(4-((3-(5-(2- Methoxyethoxy)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 15 Melanocortin receptor 4 Rattus norvegicus 26 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293983&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986182 381617099 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110505 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC(O)CO)cc4C)c3c2)cc1 293999 3-(4-(5-((4-((2S)-1-(1H- Tetrazol-5-yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-3- methylphenoxy)propane-1,2- diol::US10106553, Compound 31 Melanocortin receptor 4 Rattus norvegicus 19 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293999&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986132 381617115 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110506 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCC5(C)CS(=O)(=O)C5)cc4C)c3c2)cc1 293980 (2S)-3-((4-(5-((4-(1-(1H- Tetrazol-5-yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-3- methylphenoxy)methyl)-3- methylthietane 1,1-dioxide::US10106553, Compound 12 Melanocortin receptor 4 Rattus norvegicus 6.0 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293980 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293980&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986035 381617096 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110507 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccccc4C(F)(F)F)c3c2)cc1 293981 (2S)-5-(2-(4-((3-(2- (Trifluoromethyl)phenyl)benzo [b]thiophen-5- yl)methoxy)phenyl)pent-3-yn-1- yl)-1H-tetrazole::US10106553, Compound 13 Melanocortin receptor 4 Rattus norvegicus 2.0 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293981&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986061 381617097 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110508 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cccnc4C)c3c2)cc1 293979 (2S)-3-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-2-methylpyridine::US10106553, Compound 11 Melanocortin receptor 4 Rattus norvegicus 20 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293979&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986065 381617095 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110509 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccnn4C)c3c2)cc1 293990 (2S)-5-(2-(4-((3-(1-Methyl-1H- pyrazol-5-yl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3-yn- 1-yl)-1H-tetrazole::US10106553, Compound 22 Melanocortin receptor 4 Rattus norvegicus 32 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293990&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986082 381617106 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110510 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CC4)c3c2)cc1 294025 (2S)-5-(2-(4-((3- Cyclopropylbenzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3-yn- 1-yl)-1H-tetrazole::US10106553, Compound 57 Melanocortin receptor 4 Rattus norvegicus 239 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294025&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986162 381617141 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110511 COCCOc1ccc(-c2c(C)sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1 294014 (2S)-5-(2-(4-((3-(4-(2- Methoxyethoxy)-2- methylphenyl)-2- methylbenzo[b]thiophen-5- yl)methoxy)phenyl)pent-3-yn-1- yl)-1H-tetrazole::US10106553, Compound 46 Melanocortin receptor 4 Rattus norvegicus 32 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294014&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986378 381617130 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110512 COCCOc1ccc(-c2c(sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)C(F)(F)F)c(C)c1 294015 5-((2S)-2-(4-((3-(4-(2- Methoxyethoxy)-2- methylphenyl)-2- (trifluoromethyl)benzo[b] thiophen-5-yl)methoxy)phenyl) pent-3-yn-1-yl)-1H-tetrazole::US10106553, Compound 47 Melanocortin receptor 4 Rattus norvegicus 14 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294015&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986027 381617131 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110514 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(C4CCCCC4)c3c2)cc1 294023 (2S)-5-(2-(4-((3- Cyclohexylbenzo[b]thiophen-5- yl)methoxy)phenyl)pent-3-yn-1- yl)-1H-tetrazole::US10106553, Compound 55 Melanocortin receptor 4 Rattus norvegicus 16 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294023&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986147 381617139 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110516 COCCOc1ccc(-c2c(F)sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1 294012 (2S)-5-(2-(4-((2-Fluoro-3-(4-(2- methoxyethoxy)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 44 Melanocortin receptor 4 Rattus norvegicus 24 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294012&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986115 381617128 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110518 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(c(-c4ccccc4C)c3c2)C(F)(F)F)cc1 294004 5-((2S)-2-(4-((2- Trifluoromethyl-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- ynyl)-1H-tetrazole::US10106553, Compound 36 Melanocortin receptor 4 Rattus norvegicus 12 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294004&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986179 381617120 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110519 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCC(C)(C)O)cc4C)c3c2)cc1 293975 (2S)-4-(4-(5-((4-(1-(1H- Tetrazol-5-yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-3-methylphenoxy)- 2-methylbutan-2-ol::US10106553, Compound 7 Melanocortin receptor 4 Rattus norvegicus 4.0 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293975&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986030 381617091 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110524 COc1ccc(-c2csc3c(F)cc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1 294038 (2S)-5-(2-(4-((7-Fluoro-3-(4- methoxy-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 70 Melanocortin receptor 4 Rattus norvegicus 39 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294038&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137529002 381617154 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110527 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3[S+]([O-])C=C(c3c2)c2ccccc2C)cc1 InChI=1S/C28H24N4O2S/c1-3-6-22(16-28-29-31-32-30-28)21-10-12-23(13-11-21)34-17-20-9-14-27-25(15-20)26(18-35(27)33)24-8-5-4-7-19(24)2/h4-5,7-15,18,22H,16-17H2,1-2H3,(H,29,30,31,32)/t22-,35?/m0/s1 GRLHIHJTSFGYPR-DAJKIOHCSA-N 50453343 CHEMBL4211335 Melanocortin receptor 4 Rattus norvegicus 301 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50453343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50453343&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 145965968 433921994 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110528 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3sc(Br)c(-c4ccccc4C)c3c2)cc1 294002 5-((2S)-2-(4-((2-Bromo-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- ynyl)-1H-tetrazole::US10106553, Compound 34 Melanocortin receptor 4 Rattus norvegicus 19 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294002&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986140 381617118 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110529 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2cc(C)c3scc(-c4ccccc4C)c3c2)cc1 294031 (2S)-5-(2-(4-((7-Methyl-3-(2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 63 Melanocortin receptor 4 Rattus norvegicus 213 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294031&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137528998 381617147 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110530 COCCOc1ccc(-c2csc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1 293976 (2S)-5-(2-(4-((3-(4-(2- Methoxyethoxy)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 8 Melanocortin receptor 4 Rattus norvegicus 4.0 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293976&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986295 381617092 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110531 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4ccc(OCCCS(C)(=O)=O)cc4C)c3c2)cc1 293984 (2S)-5-(2-(4-((3-(2-Methyl-4-(3- (methylsulfonyl)propoxy)phenyl) benzo[b]thiophen-5- yl)methoxy)phenyl)pent-3-yn-1- yl)-1H-tetrazole::US10106553, Compound 16 Melanocortin receptor 4 Rattus norvegicus 9.0 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293984&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986116 381617100 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110532 CC#C[C@@H](Cc1nnn[nH]1)c1ccc(OCc2ccc3scc(-c4cncnc4C)c3c2)cc1 293993 (2S)-5-(5-((4-(1-(1H-Tetrazol-5- yl)pent-3-yn-2- yl)phenoxy)methyl)benzo[b] thiophen-3-yl)-4-methylpyrimidine::US10106553, Compound 25 Melanocortin receptor 4 Rattus norvegicus 18 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=293993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=293993&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986075 381617109 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51110533 COCCOc1ccc(-c2c(Cl)sc3ccc(COc4ccc(cc4)[C@H](Cc4nnn[nH]4)C#CC)cc23)c(C)c1 294013 (2S)-5-(2-(4-((2-Chloro-3-(4-(2- methoxyethoxy)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)pent-3- yn-1-yl)-1H-tetrazole::US10106553, Compound 45 Melanocortin receptor 4 Rattus norvegicus 21 ChEMBL 10.1016/j.bmcl.2017.12.022 10.7270/Q2833VN4 29258772 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=294013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=294013&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 131986130 381617129 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51098606 [Na+].COc1ccc(F)c(c1)-c1ccc(cc1)C1CCc2ccc(cc2O1)[C@@H]([C@H](C)C([O-])=O)C1CC1 InChI=1S/C29H29FO4.Na/c1-17(29(31)32)28(21-8-9-21)22-10-7-20-11-14-26(34-27(20)15-22)19-5-3-18(4-6-19)24-16-23(33-2)12-13-25(24)30;/h3-7,10,12-13,15-17,21,26,28H,8-9,11,14H2,1-2H3,(H,31,32);/q;+1/p-1/t17-,26?,28-;/m0./s1 MKKPXKSTHSLXDI-WYQQXALMSA-M 50367218 CHEMBL4159416 Melanocortin receptor 4 Rattus norvegicus 1.2 ChEMBL 10.1021/acsmedchemlett.8b00149 10.7270/Q29C70ZD 30034601 Chen, HY; Plummer, CW; Xiao, D; Chobanian, HR; DeMong, D; Miller, M; Trujillo, ME; Kirkland, M; Kosinski, D; Mane, J; Pachanski, M; Cheewatrakoolpong, B; Di Salvo, J; Thomas-Fowlkes, B; Souza, S; Tatosian, DA; Chen, Q; Hafey, MJ; Houle, R; Nolting, AF; Orr, R; Ehrhart, J; Weinglass, AB; Tschirret-Guth, R; Howard, AD; Colletti, SL Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367218&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 145957609 160846320 ZINC48999231 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51098619 [Na+].COc1cc(ccn1)-c1ccc([C@@H]2CCc3ccc(cc3O2)[C@@H]([C@H](C)C([O-])=O)C2CC2)c(F)c1 InChI=1S/C28H28FNO4.Na/c1-16(28(31)32)27(18-4-5-18)21-6-3-17-8-10-24(34-25(17)14-21)22-9-7-19(13-23(22)29)20-11-12-30-26(15-20)33-2;/h3,6-7,9,11-16,18,24,27H,4-5,8,10H2,1-2H3,(H,31,32);/q;+1/p-1/t16-,24-,27-;/m0./s1 RYYFJYUUBLAVKS-PDUGTDTCSA-M 50367219 CHEMBL4165147 Melanocortin receptor 4 Rattus norvegicus 0.490000 ChEMBL 10.1021/acsmedchemlett.8b00149 10.7270/Q29C70ZD 30034601 Chen, HY; Plummer, CW; Xiao, D; Chobanian, HR; DeMong, D; Miller, M; Trujillo, ME; Kirkland, M; Kosinski, D; Mane, J; Pachanski, M; Cheewatrakoolpong, B; Di Salvo, J; Thomas-Fowlkes, B; Souza, S; Tatosian, DA; Chen, Q; Hafey, MJ; Houle, R; Nolting, AF; Orr, R; Ehrhart, J; Weinglass, AB; Tschirret-Guth, R; Howard, AD; Colletti, SL Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367219&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 145961418 160846321 ZINC49767115 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51098639 [Na+].COc1ccc(F)c(c1)-c1ccc(nc1)C1CCc2ccc(cc2O1)[C@@H]([C@H](C)C([O-])=O)C1CC1 InChI=1S/C28H28FNO4.Na/c1-16(28(31)32)27(18-4-5-18)19-6-3-17-8-12-25(34-26(17)13-19)24-11-7-20(15-30-24)22-14-21(33-2)9-10-23(22)29;/h3,6-7,9-11,13-16,18,25,27H,4-5,8,12H2,1-2H3,(H,31,32);/q;+1/p-1/t16-,25?,27-;/m0./s1 URVJPHDSDQPGJZ-UCXMRBTASA-M 50367222 CHEMBL4162778 Melanocortin receptor 4 Rattus norvegicus 2.3 ChEMBL 10.1021/acsmedchemlett.8b00149 10.7270/Q29C70ZD 30034601 Chen, HY; Plummer, CW; Xiao, D; Chobanian, HR; DeMong, D; Miller, M; Trujillo, ME; Kirkland, M; Kosinski, D; Mane, J; Pachanski, M; Cheewatrakoolpong, B; Di Salvo, J; Thomas-Fowlkes, B; Souza, S; Tatosian, DA; Chen, Q; Hafey, MJ; Houle, R; Nolting, AF; Orr, R; Ehrhart, J; Weinglass, AB; Tschirret-Guth, R; Howard, AD; Colletti, SL Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367222&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 145959985 160846324 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51098640 [Na+].COc1cc(c(F)cn1)-c1ccc(nc1)C1CCc2ccc(cc2O1)[C@@H]([C@H](C)C([O-])=O)C1CC1 InChI=1S/C27H27FN2O4.Na/c1-15(27(31)32)26(17-4-5-17)18-6-3-16-8-10-23(34-24(16)11-18)22-9-7-19(13-29-22)20-12-25(33-2)30-14-21(20)28;/h3,6-7,9,11-15,17,23,26H,4-5,8,10H2,1-2H3,(H,31,32);/q;+1/p-1/t15-,23?,26-;/m0./s1 NVHIVSPHWIVTQD-BMUDFBNSSA-M 50367220 CHEMBL4168422 Melanocortin receptor 4 Rattus norvegicus 5.2 ChEMBL 10.1021/acsmedchemlett.8b00149 10.7270/Q29C70ZD 30034601 Chen, HY; Plummer, CW; Xiao, D; Chobanian, HR; DeMong, D; Miller, M; Trujillo, ME; Kirkland, M; Kosinski, D; Mane, J; Pachanski, M; Cheewatrakoolpong, B; Di Salvo, J; Thomas-Fowlkes, B; Souza, S; Tatosian, DA; Chen, Q; Hafey, MJ; Houle, R; Nolting, AF; Orr, R; Ehrhart, J; Weinglass, AB; Tschirret-Guth, R; Howard, AD; Colletti, SL Merck & Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50367220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50367220&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 145955958 160846322 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51100926 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(cc2)C(=O)N[C@@H]2CCCc3ccccc23)cc1 InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6?,7-,9+,10+,13+/m0/s1 ZJUKTBDSGOFHSH-FNYGQTGPSA-N 50405276 CHEMBL4167323 Melanocortin receptor 4 Rattus norvegicus 14 ChEMBL 10.1016/j.ejmech.2018.04.023 10.7270/Q2FT8PKV 29705709 Chen, T; Ning, M; Ye, Y; Wang, K; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405276&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 145952952 163354300 ZINC71755576 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51100927 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(cc2)C(=O)N[C@H]2CCCc3ccccc23)cc1 InChI=1S/C24H28ClN5O3/c1-16-20(10-9-19-22(31)21-24(27-28-26-21)33-23(16)19)32-14-4-11-29(2)12-13-30(3)15-17-5-7-18(25)8-6-17/h5-10,31H,4,11-15H2,1-3H3 SNHNESYIAOKIDH-UHFFFAOYSA-N 50405293 CHEMBL4166892 Melanocortin receptor 4 Rattus norvegicus 28 ChEMBL 10.1016/j.ejmech.2018.04.023 10.7270/Q2FT8PKV 29705709 Chen, T; Ning, M; Ye, Y; Wang, K; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405293&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 145953365 163354317 ZINC26379013 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51100928 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(s2)C(=O)N2CCN(CC2)c2ccc(F)cc2)cc1 InChI=1S/C28H27FN2O4S/c1-2-3-21(18-27(32)33)20-4-10-24(11-5-20)35-19-25-12-13-26(36-25)28(34)31-16-14-30(15-17-31)23-8-6-22(29)7-9-23/h4-13,21H,14-19H2,1H3,(H,32,33)/t21-/m0/s1 NHWGSOGAHPJZMM-NRFANRHFSA-N 50405440 CHEMBL4172828 Melanocortin receptor 4 Rattus norvegicus 25 ChEMBL 10.1016/j.ejmech.2018.04.023 10.7270/Q2FT8PKV 29705709 Chen, T; Ning, M; Ye, Y; Wang, K; Leng, Y; Shen, J Chinese Academy of Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405440&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 145950347 163354464 ZINC26019102 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277151 COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@H](C2CC2)C(C)(C)C(O)=O)CC1 InChI=1S/C28H35FO4/c1-28(2,27(30)31)26(20-11-12-20)21-5-4-6-23(15-21)33-17-18-7-9-19(10-8-18)24-16-22(32-3)13-14-25(24)29/h4-6,13-16,18-20,26H,7-12,17H2,1-3H3,(H,30,31)/t18-,19-,26-/m0/s1 OVDXPEDIWITCEX-DGUDUIIESA-N 50521263 CHEMBL4541658 Melanocortin receptor 4 Rattus norvegicus 0.310000 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521263&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155551422 440729845 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277158 COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)CC1 InChI=1S/C26H31FO4/c1-30-21-11-12-25(27)24(14-21)19-7-5-17(6-8-19)16-31-22-4-2-3-20(13-22)23(15-26(28)29)18-9-10-18/h2-4,11-14,17-19,23H,5-10,15-16H2,1H3,(H,28,29)/t17-,19-,23-/m0/s1 HIODEEANJKNPJV-LTMIRXACSA-N 50521269 CHEMBL4591657 Melanocortin receptor 4 Rattus norvegicus 4.1 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521269&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134465785 440729851 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277159 COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@@H]([C@H](C)C(O)=O)C2CC2)CC1 InChI=1S/C27H33FO4/c1-17(27(29)30)26(20-10-11-20)21-4-3-5-23(14-21)32-16-18-6-8-19(9-7-18)24-15-22(31-2)12-13-25(24)28/h3-5,12-15,17-20,26H,6-11,16H2,1-2H3,(H,29,30)/t17-,18-,19-,26-/m0/s1 HIZJLJKRIIOELO-YEPDHIAXSA-N 50521266 CHEMBL4463571 Melanocortin receptor 4 Rattus norvegicus 0.400000 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521266&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134465732 440729848 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277160 COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@@H]([C@H](F)C(O)=O)C2CC2)CC1 InChI=1S/C26H30F2O4/c1-31-20-11-12-23(27)22(14-20)17-7-5-16(6-8-17)15-32-21-4-2-3-19(13-21)24(18-9-10-18)25(28)26(29)30/h2-4,11-14,16-18,24-25H,5-10,15H2,1H3,(H,29,30)/t16-,17-,24-,25-/m0/s1 YURMBFWELBCIAZ-SEMUBUJISA-N 50521270 CHEMBL4443853 Melanocortin receptor 4 Rattus norvegicus 163 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521270&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155516498 440729852 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277161 COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@@H]([C@@H](F)C(O)=O)C2CC2)CC1 InChI=1S/C26H30F2O4/c1-31-20-11-12-23(27)22(14-20)17-7-5-16(6-8-17)15-32-21-4-2-3-19(13-21)24(18-9-10-18)25(28)26(29)30/h2-4,11-14,16-18,24-25H,5-10,15H2,1H3,(H,29,30)/t16-,17-,24-,25+/m0/s1 YURMBFWELBCIAZ-BSPFGIBGSA-N 50521271 CHEMBL4534836 Melanocortin receptor 4 Rattus norvegicus 28 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521271 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521271&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155549083 440729853 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277162 COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@H](C2CC2)[C@@](C)(F)C(O)=O)CC1 InChI=1S/C27H32F2O4/c1-27(29,26(30)31)25(19-10-11-19)20-4-3-5-22(14-20)33-16-17-6-8-18(9-7-17)23-15-21(32-2)12-13-24(23)28/h3-5,12-15,17-19,25H,6-11,16H2,1-2H3,(H,30,31)/t17-,18-,25-,27+/m0/s1 OBSQOGHKCGMNEP-WLUNNBRASA-N 50521268 CHEMBL4457303 Melanocortin receptor 4 Rattus norvegicus 0.340000 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521268&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134465794 440729850 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277163 COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@H](C2CC2)C(F)(F)C(O)=O)CC1 InChI=1S/C26H29F3O4/c1-32-20-11-12-23(27)22(14-20)17-7-5-16(6-8-17)15-33-21-4-2-3-19(13-21)24(18-9-10-18)26(28,29)25(30)31/h2-4,11-14,16-18,24H,5-10,15H2,1H3,(H,30,31)/t16-,17-,24-/m0/s1 UXHRJKOTJVKQIJ-UAVUOLJFSA-N 50521264 CHEMBL4459220 Melanocortin receptor 4 Rattus norvegicus 34 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521264&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155526793 440729846 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277175 Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 InChI=1S/C29H32O7S/c1-19-12-25(34-10-5-11-37(3,32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24/h4,6-9,12-14,16,23H,5,10-11,15,17-18H2,1-3H3,(H,30,31)/t23-/m1/s1 BZCALJIHZVNMGJ-HSZRJFAPSA-N 50386790 CHEMBL1829174::CHEMBL2047159::TAK-875 Melanocortin receptor 4 Rattus norvegicus 39 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386790&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 2YB 4PHU 24857286 160865873 CHEMBL2047159CHEMBL1829174 ZINC68208039 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277176 COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@@H]([C@@H](C)C(O)=O)C2CC2)CC1 InChI=1S/C27H33FO4/c1-17(27(29)30)26(20-10-11-20)21-4-3-5-23(14-21)32-16-18-6-8-19(9-7-18)24-15-22(31-2)12-13-25(24)28/h3-5,12-15,17-20,26H,6-11,16H2,1-2H3,(H,29,30)/t17-,18-,19-,26+/m1/s1 HIZJLJKRIIOELO-RHSUCHPKSA-N 50521267 CHEMBL4513748 Melanocortin receptor 4 Rattus norvegicus 4.9 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521267 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521267&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134465730 440729849 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51277177 COc1ccc(F)c(c1)[C@H]1CC[C@H](COc2cccc(c2)[C@H](C2CC2)[C@](C)(F)C(O)=O)CC1 InChI=1S/C27H32F2O4/c1-27(29,26(30)31)25(19-10-11-19)20-4-3-5-22(14-20)33-16-17-6-8-18(9-7-17)23-15-21(32-2)12-13-24(23)28/h3-5,12-15,17-19,25H,6-11,16H2,1-2H3,(H,30,31)/t17-,18-,25-,27-/m0/s1 OBSQOGHKCGMNEP-ZOJRQMPKSA-N 50521265 CHEMBL4464769 Melanocortin receptor 4 Rattus norvegicus 6.9 ChEMBL 10.1021/acsmedchemlett.8b00444 10.7270/Q2X63RBS 30655940 Huang, H; Meegalla, SK; Lanter, JC; Winters, MP; Zhao, S; Littrell, J; Qi, J; Rady, B; Lee, PS; Liu, J; Martin, T; Lam, WW; Xu, F; Lim, HK; Wilde, T; Silva, J; Otieno, M; Pocai, A; Player, MR Janssen Research & Development http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50521265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50521265&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 146316684 440729847 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395661 CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C26H21F3O3/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29/h3,5-15,21H,16-17H2,1H3,(H,30,31)/t21-/m0/s1 ZOPNBMMVVZRSGH-NRFANRHFSA-N 50362690 AMG-837::CHEMBL1829173 Melanocortin receptor 4 Rattus norvegicus 3.2 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50362690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50362690&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46854655 136966752 CHEMBL1829173 ZINC72118116 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395662 Cc1cc(OCCCS(C)(=O)=O)cc(C)c1-c1cccc(COc2ccc3[C@H](CC(O)=O)COc3c2)c1 InChI=1S/C29H32O7S/c1-19-12-25(34-10-5-11-37(3,32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24/h4,6-9,12-14,16,23H,5,10-11,15,17-18H2,1-3H3,(H,30,31)/t23-/m1/s1 BZCALJIHZVNMGJ-HSZRJFAPSA-N 50386790 CHEMBL1829174::CHEMBL2047159::TAK-875 Melanocortin receptor 4 Rattus norvegicus 36 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50386790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50386790&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 2YB 4PHU 24857286 160865873 CHEMBL2047159CHEMBL1829174 ZINC68208039 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395663 OC(=O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)cc2)cc1F InChI=1S/C30H30FNO3/c31-28-19-26(11-9-25(28)10-12-29(33)34)35-21-23-7-5-22(6-8-23)20-32-17-15-30(16-18-32)14-13-24-3-1-2-4-27(24)30/h1-9,11,13-14,19H,10,12,15-18,20-21H2,(H,33,34) ZINQKEIMTDJCFG-UHFFFAOYSA-N 50563837 CHEMBL4783190 Melanocortin receptor 4 Rattus norvegicus 160 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563837&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 58230552 461684175 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395664 OC(=O)CCc1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)cc2)cc1Cl InChI=1S/C30H30ClNO3/c31-28-19-26(11-9-25(28)10-12-29(33)34)35-21-23-7-5-22(6-8-23)20-32-17-15-30(16-18-32)14-13-24-3-1-2-4-27(24)30/h1-9,11,13-14,19H,10,12,15-18,20-21H2,(H,33,34) LFJKGEYLBWLFPM-UHFFFAOYSA-N 50563838 CHEMBL4794904 Melanocortin receptor 4 Rattus norvegicus 540 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563838&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 58230598 461684176 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395665 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)cc2)cc1 InChI=1S/C33H33NO3/c1-2-5-29(22-32(35)36)27-12-14-30(15-13-27)37-24-26-10-8-25(9-11-26)23-34-20-18-33(19-21-34)17-16-28-6-3-4-7-31(28)33/h3-4,6-17,29H,18-24H2,1H3,(H,35,36)/t29-/m0/s1 FHRWHNJJQGSCQC-LJAQVGFWSA-N 50200369 CHEMBL3915620 Melanocortin receptor 4 Rattus norvegicus 2.0 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50200369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50200369&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 51049992 375978853 CHEMBL3915620 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395666 CC#C[C@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)cc2)cc1 InChI=1S/C33H33NO3/c1-2-5-29(22-32(35)36)27-12-14-30(15-13-27)37-24-26-10-8-25(9-11-26)23-34-20-18-33(19-21-34)17-16-28-6-3-4-7-31(28)33/h3-4,6-17,29H,18-24H2,1H3,(H,35,36)/t29-/m1/s1 FHRWHNJJQGSCQC-GDLZYMKVSA-N 50563839 CHEMBL4792027 Melanocortin receptor 4 Rattus norvegicus 120 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563839&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 132578495 461684177 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395667 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)cc2)cc1F InChI=1S/C33H32FNO3/c1-2-5-27(20-32(36)37)29-13-12-28(21-31(29)34)38-23-25-10-8-24(9-11-25)22-35-18-16-33(17-19-35)15-14-26-6-3-4-7-30(26)33/h3-4,6-15,21,27H,16-20,22-23H2,1H3,(H,36,37)/t27-/m0/s1 NEGIWTYBODMDQN-MHZLTWQESA-N 50563840 CHEMBL4787628 Melanocortin receptor 4 Rattus norvegicus 16 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563840&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162667620 461684178 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395668 CC#C[C@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)cc2)cc1F InChI=1S/C33H32FNO3/c1-2-5-27(20-32(36)37)29-13-12-28(21-31(29)34)38-23-25-10-8-24(9-11-25)22-35-18-16-33(17-19-35)15-14-26-6-3-4-7-30(26)33/h3-4,6-15,21,27H,16-20,22-23H2,1H3,(H,36,37)/t27-/m1/s1 NEGIWTYBODMDQN-HHHXNRCGSA-N 50563841 CHEMBL4786299 Melanocortin receptor 4 Rattus norvegicus 420 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563841&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162666840 461684179 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395669 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)c(F)c2)cc1 InChI=1S/C33H32FNO3/c1-2-5-27(21-32(36)37)25-10-12-29(13-11-25)38-23-24-8-9-28(31(34)20-24)22-35-18-16-33(17-19-35)15-14-26-6-3-4-7-30(26)33/h3-4,6-15,20,27H,16-19,21-23H2,1H3,(H,36,37)/t27-/m0/s1 ODKHJVBQRWOSHU-MHZLTWQESA-N 50563842 CHEMBL4798023 Melanocortin receptor 4 Rattus norvegicus 1.3 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563842&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162674998 461684180 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395670 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)c(Cl)c2)cc1 InChI=1S/C33H32ClNO3/c1-2-5-27(21-32(36)37)25-10-12-29(13-11-25)38-23-24-8-9-28(31(34)20-24)22-35-18-16-33(17-19-35)15-14-26-6-3-4-7-30(26)33/h3-4,6-15,20,27H,16-19,21-23H2,1H3,(H,36,37)/t27-/m0/s1 QBCNRSGMLSPYQX-MHZLTWQESA-N 50563843 CHEMBL4798993 Melanocortin receptor 4 Rattus norvegicus 1.000000 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563843&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162674654 461684181 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395671 COc1cc(COc2ccc(cc2)[C@H](CC(O)=O)C#CC)ccc1CN1CCC2(CC1)C=Cc1ccccc21 InChI=1S/C34H35NO4/c1-3-6-28(22-33(36)37)26-11-13-30(14-12-26)39-24-25-9-10-29(32(21-25)38-2)23-35-19-17-34(18-20-35)16-15-27-7-4-5-8-31(27)34/h4-5,7-16,21,28H,17-20,22-24H2,1-2H3,(H,36,37)/t28-/m0/s1 QWYNYEMJGNQUMA-NDEPHWFRSA-N 50563844 CHEMBL4781604 Melanocortin receptor 4 Rattus norvegicus 3.0 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563844&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162664735 461684182 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395672 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)c(C)c2)cc1 InChI=1S/C34H35NO3/c1-3-6-29(22-33(36)37)27-11-13-31(14-12-27)38-24-26-9-10-30(25(2)21-26)23-35-19-17-34(18-20-35)16-15-28-7-4-5-8-32(28)34/h4-5,7-16,21,29H,17-20,22-24H2,1-2H3,(H,36,37)/t29-/m0/s1 GGKYTKCGFFHJRU-LJAQVGFWSA-N 50563845 CHEMBL4793371 Melanocortin receptor 4 Rattus norvegicus 0.540000 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563845&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162673875 461684183 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395673 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)c(c2)C(F)(F)F)cc1 InChI=1S/C34H32F3NO3/c1-2-5-27(21-32(39)40)25-10-12-29(13-11-25)41-23-24-8-9-28(31(20-24)34(35,36)37)22-38-18-16-33(17-19-38)15-14-26-6-3-4-7-30(26)33/h3-4,6-15,20,27H,16-19,21-23H2,1H3,(H,39,40)/t27-/m0/s1 ZFECBEZYHLZTCS-MHZLTWQESA-N 50563846 CHEMBL4787010 Melanocortin receptor 4 Rattus norvegicus 1.1 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563846&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162668378 461684184 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395674 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)o2)cc1 InChI=1S/C31H31NO4/c1-2-5-25(20-30(33)34)23-8-10-26(11-9-23)35-22-28-13-12-27(36-28)21-32-18-16-31(17-19-32)15-14-24-6-3-4-7-29(24)31/h3-4,6-15,25H,16-22H2,1H3,(H,33,34)/t25-/m0/s1 NCQOCNBTDFNURU-VWLOTQADSA-N 50563847 CHEMBL4792075 Melanocortin receptor 4 Rattus norvegicus 4.2 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563847&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 68194476 461684185 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395675 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)C=Cc3ccccc43)s2)cc1 InChI=1S/C31H31NO3S/c1-2-5-25(20-30(33)34)23-8-10-26(11-9-23)35-22-28-13-12-27(36-28)21-32-18-16-31(17-19-32)15-14-24-6-3-4-7-29(24)31/h3-4,6-15,25H,16-22H2,1H3,(H,33,34)/t25-/m0/s1 YSVQUSMRABAJAR-VWLOTQADSA-N 50563848 CHEMBL4782004 Melanocortin receptor 4 Rattus norvegicus 0.930000 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563848&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 52936292 461684186 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395676 CC#C[C@@H](CC(O)=O)c1ccc(OCc2cc(C)c(CN3CCC4(CC3)C=Cc3ccccc43)s2)cc1 InChI=1S/C32H33NO3S/c1-3-6-26(20-31(34)35)24-9-11-27(12-10-24)36-22-28-19-23(2)30(37-28)21-33-17-15-32(16-18-33)14-13-25-7-4-5-8-29(25)32/h4-5,7-14,19,26H,15-18,20-22H2,1-2H3,(H,34,35)/t26-/m0/s1 WZOVXNKWRTVWKI-SANMLTNESA-N 50563849 CHEMBL4797124 Melanocortin receptor 4 Rattus norvegicus 1.1 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563849&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 68194465 461684187 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395677 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ncc(CN3CCC4(CC3)C=Cc3ccccc43)s2)cc1 InChI=1S/C30H30N2O3S/c1-2-5-24(18-29(33)34)22-8-10-25(11-9-22)35-21-28-31-19-26(36-28)20-32-16-14-30(15-17-32)13-12-23-6-3-4-7-27(23)30/h3-4,6-13,19,24H,14-18,20-21H2,1H3,(H,33,34)/t24-/m0/s1 QBQDRXNVVTZECL-DEOSSOPVSA-N 50563850 CHEMBL4795763 Melanocortin receptor 4 Rattus norvegicus 23 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563850&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 68194127 461684188 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395678 CC#C[C@@H](CC(O)=O)c1ccc(OCc2cnc(CN3CCC4(CC3)C=Cc3ccccc43)s2)cc1 InChI=1S/C30H30N2O3S/c1-2-5-24(18-29(33)34)22-8-10-25(11-9-22)35-21-26-19-31-28(36-26)20-32-16-14-30(15-17-32)13-12-23-6-3-4-7-27(23)30/h3-4,6-13,19,24H,14-18,20-21H2,1H3,(H,33,34)/t24-/m0/s1 LJLSDEMEFGKOKZ-DEOSSOPVSA-N 50563851 CHEMBL4790921 Melanocortin receptor 4 Rattus norvegicus 11 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563851&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 68194449 461684189 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395679 CC#C[C@@H](CC(O)=O)c1ccc(OCc2sc(CN3CCC4(CC3)C=Cc3ccccc43)nc2C)cc1 InChI=1S/C31H32N2O3S/c1-3-6-25(19-30(34)35)23-9-11-26(12-10-23)36-21-28-22(2)32-29(37-28)20-33-17-15-31(16-18-33)14-13-24-7-4-5-8-27(24)31/h4-5,7-14,25H,15-21H2,1-2H3,(H,34,35)/t25-/m0/s1 IBBXYPXDPQQROL-VWLOTQADSA-N 50563852 CHEMBL4794233 Melanocortin receptor 4 Rattus norvegicus 100 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563852&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 68194159 461684190 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395680 CC#C[C@@H](CC(O)=O)c1ccc(OCc2nc(C)c(CN3CCC4(CC3)C=Cc3ccccc43)s2)cc1 InChI=1S/C31H32N2O3S/c1-3-6-25(19-30(34)35)23-9-11-26(12-10-23)36-21-29-32-22(2)28(37-29)20-33-17-15-31(16-18-33)14-13-24-7-4-5-8-27(24)31/h4-5,7-14,25H,15-21H2,1-2H3,(H,34,35)/t25-/m0/s1 SXBDSTLZQNSEGA-VWLOTQADSA-N 50563853 CHEMBL4783033 Melanocortin receptor 4 Rattus norvegicus 17 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563853&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 68194237 461684191 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395681 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc45)CC3)cc2)cc1 InChI=1S/C33H35NO3/c1-2-5-29(22-32(35)36)27-12-14-30(15-13-27)37-24-26-10-8-25(9-11-26)23-34-20-18-33(19-21-34)17-16-28-6-3-4-7-31(28)33/h3-4,6-15,29H,16-24H2,1H3,(H,35,36)/t29-/m0/s1 WKVVLTUTCPYXBP-LJAQVGFWSA-N 50563854 CHEMBL4791842 Melanocortin receptor 4 Rattus norvegicus 1.3 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563854&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 67087246 461684192 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395682 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CN(C)c5ccccc45)CC3)cc2)cc1 InChI=1S/C33H36N2O3/c1-3-6-28(21-32(36)37)27-13-15-29(16-14-27)38-23-26-11-9-25(10-12-26)22-35-19-17-33(18-20-35)24-34(2)31-8-5-4-7-30(31)33/h4-5,7-16,28H,17-24H2,1-2H3,(H,36,37)/t28-/m0/s1 QRCCYPSGLCYDNW-NDEPHWFRSA-N 50563855 CHEMBL4780641 Melanocortin receptor 4 Rattus norvegicus 5.5 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563855&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 51357276 461684193 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395683 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CN(C(C)C)c5ccccc45)CC3)cc2)cc1 InChI=1S/C35H40N2O3/c1-4-7-30(22-34(38)39)29-14-16-31(17-15-29)40-24-28-12-10-27(11-13-28)23-36-20-18-35(19-21-36)25-37(26(2)3)33-9-6-5-8-32(33)35/h5-6,8-17,26,30H,18-25H2,1-3H3,(H,38,39)/t30-/m0/s1 DQWYVKIYWPYHFR-PMERELPUSA-N 50563856 CHEMBL4800563 Melanocortin receptor 4 Rattus norvegicus 2.1 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563856&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162676881 461684194 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395684 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CN(c5ccccc45)c4ccccc4)CC3)cc2)cc1 InChI=1S/C38H38N2O3/c1-2-8-32(25-37(41)42)31-17-19-34(20-18-31)43-27-30-15-13-29(14-16-30)26-39-23-21-38(22-24-39)28-40(33-9-4-3-5-10-33)36-12-7-6-11-35(36)38/h3-7,9-20,32H,21-28H2,1H3,(H,41,42)/t32-/m0/s1 YPPVVNXEJUDPRL-YTTGMZPUSA-N 50563857 CHEMBL4797858 Melanocortin receptor 4 Rattus norvegicus 0.830000 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563857&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 67087095 461684195 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395685 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CN(C)c5c4cccc5Cl)CC3)cc2)cc1 InChI=1S/C33H35ClN2O3/c1-3-5-27(20-31(37)38)26-12-14-28(15-13-26)39-22-25-10-8-24(9-11-25)21-36-18-16-33(17-19-36)23-35(2)32-29(33)6-4-7-30(32)34/h4,6-15,27H,16-23H2,1-2H3,(H,37,38)/t27-/m0/s1 QYQPCBXOKNSAPQ-MHZLTWQESA-N 50563858 CHEMBL4785057 Melanocortin receptor 4 Rattus norvegicus 0.890000 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563858&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 67087041 461684196 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395686 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CN(C)c5ccc(C)cc45)CC3)cc2)cc1 InChI=1S/C34H38N2O3/c1-4-5-29(21-33(37)38)28-11-13-30(14-12-28)39-23-27-9-7-26(8-10-27)22-36-18-16-34(17-19-36)24-35(3)32-15-6-25(2)20-31(32)34/h6-15,20,29H,16-19,21-24H2,1-3H3,(H,37,38)/t29-/m0/s1 LCBHFUFPPJJGPP-LJAQVGFWSA-N 50563859 CHEMBL4786335 Melanocortin receptor 4 Rattus norvegicus 4.6 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563859&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 67087173 461684197 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395687 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CN(C)c5ccc(cc45)C(F)(F)F)CC3)cc2)cc1 InChI=1S/C34H35F3N2O3/c1-3-4-27(19-32(40)41)26-9-12-29(13-10-26)42-22-25-7-5-24(6-8-25)21-39-17-15-33(16-18-39)23-38(2)31-14-11-28(20-30(31)33)34(35,36)37/h5-14,20,27H,15-19,21-23H2,1-2H3,(H,40,41)/t27-/m0/s1 KOQJZRRRDHXPJJ-MHZLTWQESA-N 50563860 CHEMBL4788206 Melanocortin receptor 4 Rattus norvegicus 0.590000 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563860&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 67087100 461684198 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395688 COc1ccc2N(C)CC3(CCN(Cc4ccc(COc5ccc(cc5)[C@H](CC(O)=O)C#CC)cc4)CC3)c2c1 InChI=1S/C34H38N2O4/c1-4-5-28(20-33(37)38)27-10-12-29(13-11-27)40-23-26-8-6-25(7-9-26)22-36-18-16-34(17-19-36)24-35(2)32-15-14-30(39-3)21-31(32)34/h6-15,21,28H,16-20,22-24H2,1-3H3,(H,37,38)/t28-/m0/s1 QYMPSBVGDMAOKX-NDEPHWFRSA-N 50563861 CHEMBL4784555 Melanocortin receptor 4 Rattus norvegicus 18 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563861&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 67087160 461684199 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395689 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CC3)CC(=O)c3ccccc3O4)cc2)cc1 InChI=1S/C33H33NO5/c1-2-5-27(20-32(36)37)26-12-14-28(15-13-26)38-23-25-10-8-24(9-11-25)22-34-18-16-33(17-19-34)21-30(35)29-6-3-4-7-31(29)39-33/h3-4,6-15,27H,16-23H2,1H3,(H,36,37)/t27-/m0/s1 CEVBGMGJZAYACN-MHZLTWQESA-N 50563862 CHEMBL4799453 Melanocortin receptor 4 Rattus norvegicus 4.5 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563862&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162676686 461684200 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395690 CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc(CN3CCC4(CCc5ccccc45)CC3)s2)cc1 InChI=1S/C31H33NO3S/c1-2-5-25(20-30(33)34)23-8-10-26(11-9-23)35-22-28-13-12-27(36-28)21-32-18-16-31(17-19-32)15-14-24-6-3-4-7-29(24)31/h3-4,6-13,25H,14-22H2,1H3,(H,33,34)/t25-/m0/s1 LGIUHWQDGPFXSG-VWLOTQADSA-N 50563863 CHEMBL4787498 Melanocortin receptor 4 Rattus norvegicus 1.7 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563863&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 68194743 461684201 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395691 COc1cccc2CCCN(Cc3ccc(COc4ccc(cc4)[C@H](CC(O)=O)C#CC)s3)c12 InChI=1S/C28H29NO4S/c1-3-6-22(17-27(30)31)20-10-12-23(13-11-20)33-19-25-15-14-24(34-25)18-29-16-5-8-21-7-4-9-26(32-2)28(21)29/h4,7,9-15,22H,5,8,16-19H2,1-2H3,(H,30,31)/t22-/m0/s1 VJVDLRVFJTVWEO-QFIPXVFZSA-N 50204012 CHEMBL3955132 Melanocortin receptor 4 Rattus norvegicus 3.0 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50204012 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50204012&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71257551 375980277 CHEMBL3955132 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51395692 OC(=O)C[C@H](c1ccon1)c1ccc(OCc2ccc3nc(nn3c2)-c2ccccc2)cc1 InChI=1S/C25H20N4O4/c30-24(31)14-21(22-12-13-33-28-22)18-7-9-20(10-8-18)32-16-17-6-11-23-26-25(27-29(23)15-17)19-4-2-1-3-5-19/h1-13,15,21H,14,16H2,(H,30,31)/t21-/m0/s1 KIZDOKWMTBVGAP-NRFANRHFSA-N 50563864 CHEMBL4778264 Melanocortin receptor 4 Rattus norvegicus 14000 ChEMBL 10.1021/acs.jmedchem.6b00892 10.7270/Q2GH9NPC 27749056 Hamdouchi, C; Kahl, SD; Patel Lewis, A; Cardona, GR; Zink, RW; Chen, K; Eessalu, TE; Ficorilli, JV; Marcelo, MC; Otto, KA; Wilbur, KL; Lineswala, JP; Piper, JL; Coffey, DS; Sweetana, SA; Haas, JV; Brooks, DA; Pratt, EJ; Belin, RM; Deeg, MA; Ma, X; Cannady, EA; Johnson, JT; Yumibe, NP; Chen, Q; Maiti, P; Montrose-Rafizadeh, C; Chen, Y; Reifel Miller, A Lilly Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50563864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50563864&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162644059 461684202 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355090 COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)C InChI=1S/C27H30FN3O4/c1-16(2)9-24-27(22-11-25(34-3)29-14-23(22)28)30-13-19(31-24)15-35-20-6-4-5-18(10-20)21(12-26(32)33)17-7-8-17/h4-6,10-11,13-14,16-17,21H,7-9,12,15H2,1-3H3,(H,32,33)/t21-/m0/s1 FNXMDDKBLZLDDD-NRFANRHFSA-N 168191 US9688642, 2 Melanocortin receptor 4 Rattus norvegicus 862000 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168191&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645756 363891292 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355091 COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)C InChI=1S/C27H30FN3O4/c1-16(2)9-24-27(22-11-25(34-3)29-14-23(22)28)30-13-19(31-24)15-35-20-6-4-5-18(10-20)21(12-26(32)33)17-7-8-17/h4-6,10-11,13-14,16-17,21H,7-9,12,15H2,1-3H3,(H,32,33)/t21-/m0/s1 FNXMDDKBLZLDDD-NRFANRHFSA-N 168191 US9688642, 2 Melanocortin receptor 4 Rattus norvegicus 547 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168191&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645756 363891292 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355093 CCCCc1nc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cnc1-c1cc(OC)ccc1F InChI=1S/C28H31FN2O4/c1-3-4-8-26-28(24-14-21(34-2)11-12-25(24)29)30-16-20(31-26)17-35-22-7-5-6-19(13-22)23(15-27(32)33)18-9-10-18/h5-7,11-14,16,18,23H,3-4,8-10,15,17H2,1-2H3,(H,32,33)/t23-/m0/s1 CAASMGSVVAKSNP-QHCPKHFHSA-N 168170 US9688642, 3 Melanocortin receptor 4 Rattus norvegicus 28 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168170&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645789 373986961 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355094 COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1-c1cc(C)cc(C)c1 InChI=1S/C32H31FN2O4/c1-19-11-20(2)13-23(12-19)31-32(28-15-25(38-3)9-10-29(28)33)34-17-24(35-31)18-39-26-6-4-5-22(14-26)27(16-30(36)37)21-7-8-21/h4-6,9-15,17,21,27H,7-8,16,18H2,1-3H3,(H,36,37)/t27-/m0/s1 UULGQLZCNJQSHT-MHZLTWQESA-N 168162 US9688642, 10 Melanocortin receptor 4 Rattus norvegicus 31 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168162&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645541 363891266 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355095 COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1N1CC2(CCC2)C1 InChI=1S/C30H32FN3O4/c1-37-22-8-9-26(31)25(13-22)28-29(34-17-30(18-34)10-3-11-30)33-21(15-32-28)16-38-23-5-2-4-20(12-23)24(14-27(35)36)19-6-7-19/h2,4-5,8-9,12-13,15,19,24H,3,6-7,10-11,14,16-18H2,1H3,(H,35,36)/t24-/m0/s1 JYLWVVVEZCMZEJ-DEOSSOPVSA-N 168166 US9688642, 6 Melanocortin receptor 4 Rattus norvegicus 16 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168166&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645526 363891270 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355096 COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1OCC(C)C InChI=1S/C28H31FN2O5/c1-17(2)15-36-28-27(24-12-21(34-3)9-10-25(24)29)30-14-20(31-28)16-35-22-6-4-5-19(11-22)23(13-26(32)33)18-7-8-18/h4-6,9-12,14,17-18,23H,7-8,13,15-16H2,1-3H3,(H,32,33)/t23-/m0/s1 JCCLBNNUYSQXLM-QHCPKHFHSA-N 168182 US9688642, 14 Melanocortin receptor 4 Rattus norvegicus 24 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168182&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645392 363891285 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355097 COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)(C)C InChI=1S/C29H33FN2O4/c1-29(2,3)15-26-28(24-13-21(35-4)10-11-25(24)30)31-16-20(32-26)17-36-22-7-5-6-19(12-22)23(14-27(33)34)18-8-9-18/h5-7,10-13,16,18,23H,8-9,14-15,17H2,1-4H3,(H,33,34)/t23-/m0/s1 WOLFEJUCBJJIIB-QHCPKHFHSA-N 168171 US9688642, 1 Melanocortin receptor 4 Rattus norvegicus 32 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168171&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645685 363891274 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355098 COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1CC(C)C InChI=1S/C27H30FN3O4/c1-16(2)9-24-27(22-11-25(34-3)29-14-23(22)28)30-13-19(31-24)15-35-20-6-4-5-18(10-20)21(12-26(32)33)17-7-8-17/h4-6,10-11,13-14,16-17,21H,7-9,12,15H2,1-3H3,(H,32,33)/t21-/m0/s1 FNXMDDKBLZLDDD-NRFANRHFSA-N 168191 US9688642, 2 Melanocortin receptor 4 Rattus norvegicus 17 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168191&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645756 363891292 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355099 COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C=C(C)C InChI=1S/C28H29FN2O4/c1-17(2)11-26-28(24-13-21(34-3)9-10-25(24)29)30-15-20(31-26)16-35-22-6-4-5-19(12-22)23(14-27(32)33)18-7-8-18/h4-6,9-13,15,18,23H,7-8,14,16H2,1-3H3,(H,32,33)/t23-/m0/s1 HTHLUKBDLHQQTK-QHCPKHFHSA-N 168177 US9688642, 8 Melanocortin receptor 4 Rattus norvegicus 49 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168177&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645671 363891280 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355100 COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C InChI=1S/C30H32FN3O4/c1-30(2)11-5-8-24(30)29-28(23-13-26(37-3)32-16-25(23)31)33-15-20(34-29)17-38-21-7-4-6-19(12-21)22(14-27(35)36)18-9-10-18/h4,6-8,12-13,15-16,18,22H,5,9-11,14,17H2,1-3H3,(H,35,36)/t22-/m0/s1 NEANWAJDBGJJSW-QFIPXVFZSA-N 168184 US9688642, 15::US9688642, 30 Melanocortin receptor 4 Rattus norvegicus 18 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168184&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645715 363891287 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355101 COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C InChI=1S/C31H33FN2O4/c1-31(2)13-5-8-26(31)30-29(25-15-22(37-3)11-12-27(25)32)33-17-21(34-30)18-38-23-7-4-6-20(14-23)24(16-28(35)36)19-9-10-19/h4,6-8,11-12,14-15,17,19,24H,5,9-10,13,16,18H2,1-3H3,(H,35,36)/t24-/m0/s1 RPNNZNQBXGKPGZ-DEOSSOPVSA-N 168156 US9688642, 46 Melanocortin receptor 4 Rattus norvegicus 201 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=168156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=168156&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118645367 363891260 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355102 COc1ccc(F)c(c1)-c1cnc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C InChI=1S/C31H33FN2O4/c1-31(2)13-5-8-26(31)30-25(24-15-21(37-3)11-12-27(24)32)17-33-28(34-30)18-38-22-7-4-6-20(14-22)23(16-29(35)36)19-9-10-19/h4,6-8,11-12,14-15,17,19,23H,5,9-10,13,16,18H2,1-3H3,(H,35,36)/t23-/m0/s1 CCZZWYVXFVNTJG-QHCPKHFHSA-N 50548187 CHEMBL4740846 Melanocortin receptor 4 Rattus norvegicus 70 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548187&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162646017 461678527 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355103 COc1ccc(F)c(c1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cc1C1=CCCC1(C)C InChI=1S/C32H34FNO4/c1-32(2)13-5-8-28(32)26-14-20(18-34-31(26)27-16-23(37-3)11-12-29(27)33)19-38-24-7-4-6-22(15-24)25(17-30(35)36)21-9-10-21/h4,6-8,11-12,14-16,18,21,25H,5,9-10,13,17,19H2,1-3H3,(H,35,36)/t25-/m0/s1 UKYDVZZBAHFCGT-VWLOTQADSA-N 50548188 CHEMBL4749949 Melanocortin receptor 4 Rattus norvegicus 64 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548188&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162652399 461678528 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355104 COc1ccc(F)c(c1)-c1ccc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C InChI=1S/C32H34FNO4/c1-32(2)15-5-8-28(32)31-25(27-17-23(37-3)12-14-29(27)33)13-11-22(34-31)19-38-24-7-4-6-21(16-24)26(18-30(35)36)20-9-10-20/h4,6-8,11-14,16-17,20,26H,5,9-10,15,18-19H2,1-3H3,(H,35,36)/t26-/m0/s1 WSECGFLGUSNJDA-SANMLTNESA-N 50548189 CHEMBL4761101 Melanocortin receptor 4 Rattus norvegicus 45 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548189&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162659599 461678529 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355105 COc1ccc(F)c(c1)-c1cnc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cc1C1=CCCC1(C)C InChI=1S/C32H34FNO4/c1-32(2)13-5-8-29(32)26-15-22(34-18-28(26)27-16-23(37-3)11-12-30(27)33)19-38-24-7-4-6-21(14-24)25(17-31(35)36)20-9-10-20/h4,6-8,11-12,14-16,18,20,25H,5,9-10,13,17,19H2,1-3H3,(H,35,36)/t25-/m0/s1 JGZMKZHCWGDOPI-VWLOTQADSA-N 50548190 CHEMBL4787007 Melanocortin receptor 4 Rattus norvegicus 46 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50548190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50548190&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162668241 461678530 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51355106 COc1ccc(F)c(c1)-c1ccc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cc1C1=CCCC1(C)C InChI=1S/C33H35FO4/c1-33(2)15-5-8-30(33)28-16-21(9-13-26(28)29-18-24(37-3)12-14-31(29)34)20-38-25-7-4-6-23(17-25)27(19-32(35)36)22-10-11-22/h4,6-9,12-14,16-18,22,27H,5,10-11,15,19-20H2,1-3H3,(H,35,36)/t27-/m0/s1 CHEANNSDVJOIBS-MHZLTWQESA-N 50392861 CHEMBL2152070 Melanocortin receptor 4 Rattus norvegicus 11 ChEMBL 10.1016/j.bmcl.2018.01.013 10.7270/Q21R6V4X 29366647 Meegalla, SK; Huang, H; Martin, T; Xu, J; Zhao, S; Liu, J; Hall, M; Gunnet, J; Wang, Y; Rady, B; Silva, J; Otieno, M; Arnoult, E; Paul Lee, S; Pocai, A; Player, MR Janssen Research & Developmen, LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50392861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50392861&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 57706778 163341885 CHEMBL2152070 ZINC95576548 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY Melanocortin receptor 4 MC4R_RAT P70596 51540800 C[C@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O InChI=1S/C49H68N18O9S2/c1-26-41(70)63-37(20-30-22-55-25-59-30)46(75)64-35(18-28-10-4-3-5-11-28)44(73)62-34(15-9-17-57-49(53)54)43(72)65-36(19-29-21-58-32-13-7-6-12-31(29)32)45(74)66-38(40(50)69)23-77-78-24-39(47(76)60-26)67-42(71)33(61-27(2)68)14-8-16-56-48(51)52/h3-7,10-13,21-22,25-26,33-39,58H,8-9,14-20,23-24H2,1-2H3,(H2,50,69)(H,55,59)(H,60,76)(H,61,68)(H,62,73)(H,63,70)(H,64,75)(H,65,72)(H,66,74)(H,67,71)(H4,51,52,56)(H4,53,54,57)/t26-,33+,34+,35-,36+,37+,38+,39+/m1/s1 HDHDTKMUACZDAA-PHNIDTBTSA-N 50581319 BIM-22493::RM-493::SETMELANOTIDE::Setmelanotide Melanocortin receptor 4 Rattus norvegicus 0.280000 ChEMBL 10.1016/j.ejmech.2022.114742 10.7270/Q2GT5SHC 36155354 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50581319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50581319&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11993702 476026324 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_RAT P70596 51533983 COc1cc([C@@H](C)C(=O)N2CC[C@]3(C2)COc2cc(c(C)nc2N3)-c2ncccn2)c(F)cn1 InChI=1S/C24H25FN6O3/c1-14(16-10-20(33-3)28-11-18(16)25)23(32)31-8-5-24(12-31)13-34-19-9-17(15(2)29-22(19)30-24)21-26-6-4-7-27-21/h4,6-7,9-11,14H,5,8,12-13H2,1-3H3,(H,29,30)/t14-,24+/m1/s1 GDRJSPPVRGELGB-SHACYNPGSA-N 50617048 CHEMBL5432266 Melanocortin receptor 4 Rattus norvegicus 0.520000 ChEMBL 10.1021/acs.jmedchem.2c02012 10.7270/Q2KP86H1 36802610 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50617048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001133&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50617048&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_RAT P70596