BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51299846 COc1cc(\C=C\C(=O)O[C@H]2[C@@H](C[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC=C3[C@@H]5[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]43C)C(O)=O)C2(C)C)OC(C)=O)ccc1O InChI=1S/C42H58O9/c1-24-16-19-42(36(46)47)21-20-39(6)27(34(42)41(24,8)48)12-14-32-38(5)23-30(50-25(2)43)35(37(3,4)31(38)17-18-40(32,39)7)51-33(45)15-11-26-10-13-28(44)29(22-26)49-9/h10-13,15,22,24,30-32,34-35,44,48H,14,16-21,23H2,1-9H3,(H,46,47)/b15-11+/t24-,30-,31+,32-,34-,35+,38+,39-,40-,41-,42+/m1/s1 KVCWSRZTJGVXQK-ZNTLCHEGSA-N 50529620 CHEMBL4558600 Glycogen [starch] synthase, liver 4100 ChEMBL 10.1021/acs.jnatprod.8b00079 10.7270/Q2VM4GRR 30336025 Kasangana, PB; Haddad, PS; Eid, HM; Nachar, A; Stevanovic, T Universit£ Laval http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529620&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 155557513 440738202 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 51299848 COc1cc(\C=C\C(=O)O[C@H]2[C@@H](C[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC=C3[C@@H]5[C@](C)(O)[C@H](C)CC[C@@]5(CC[C@@]43C)C(O)=O)C2(C)C)OC(C)=O)ccc1O InChI=1S/C42H58O9/c1-24-16-19-42(36(46)47)21-20-39(6)27(34(42)41(24,8)48)12-14-32-38(5)23-30(50-25(2)43)35(37(3,4)31(38)17-18-40(32,39)7)51-33(45)15-11-26-10-13-28(44)29(22-26)49-9/h10-13,15,22,24,30-32,34-35,44,48H,14,16-21,23H2,1-9H3,(H,46,47)/b15-11+/t24-,30-,31+,32-,34-,35+,38+,39-,40-,41-,42+/m1/s1 KVCWSRZTJGVXQK-ZNTLCHEGSA-N 50529620 CHEMBL4558600 Glycogen [starch] synthase, liver 4100 ChEMBL 10.1021/acs.jnatprod.8b00079 10.7270/Q2VM4GRR 30336025 Kasangana, PB; Haddad, PS; Eid, HM; Nachar, A; Stevanovic, T Universit£ Laval http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50529620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50529620&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 155557513 440738202 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349701 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(o1)C(F)F)c1ccccc1 InChI=1S/C26H26F4N4O3/c1-14(2)18-9-8-16(10-19(18)28)23(15-6-4-3-5-7-15)31-25(36)20-11-17(27)13-34(20)22(35)12-21-32-33-26(37-21)24(29)30/h3-10,14,17,20,23-24H,11-13H2,1-2H3,(H,31,36)/t17-,20+,23+/m1/s1 ZWGDUALSLOOGHN-MONBJTKQSA-N 634934 US11814367, Compound 383 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634934&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349702 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnnc1)c1ccccc1 InChI=1S/C25H27F2N5O2/c1-16(2)20-9-8-18(10-21(20)27)24(17-6-4-3-5-7-17)30-25(34)22-11-19(26)12-32(22)23(33)13-31-14-28-29-15-31/h3-10,14-16,19,22,24H,11-13H2,1-2H3,(H,30,34)/t19-,22+,24+/m1/s1 DIWKRVVNQICHIU-UCFCWBNQSA-N 634935 US11814367, Compound 384 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634935&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349703 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 634936 US11814367, Compound 385 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634936&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349704 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C)c(=O)n(C)c1=O)c1ccccc1 InChI=1S/C28H31F2N5O4/c1-16(2)20-10-11-21(31-25(20)30)24(18-8-6-5-7-9-18)32-26(37)22-12-19(29)14-35(22)23(36)15-34-13-17(3)27(38)33(4)28(34)39/h5-11,13,16,19,22,24H,12,14-15H2,1-4H3,(H,32,37)/t19-,22+,24+/m1/s1 MIQLBDJOBGVDGS-UCFCWBNQSA-N 634937 US11814367, Compound 386::US11814367, Compound 777 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634937&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349705 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cccc2nc(C)ccc12)c1ccccc1 InChI=1S/C32H32F2N4O2/c1-19(2)24-14-15-27(36-31(24)34)30(21-8-5-4-6-9-21)37-32(40)28-17-23(33)18-38(28)29(39)16-22-10-7-11-26-25(22)13-12-20(3)35-26/h4-15,19,23,28,30H,16-18H2,1-3H3,(H,37,40)/t23-,28+,30+/m1/s1 LGNNNBSEVAEHFW-SLTKKEMYSA-N 634938 US11814367, Compound 387 Glycogen [starch] synthase, liver 36220 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634938&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349706 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C)c(=O)[nH]c1=O)c1ccccc1 634939 US11814367, Compound 388::US11814367, Compound 778 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634939&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349707 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnc2ccccc12)c1ccccc1 InChI=1S/C29H29F2N5O2/c1-18(2)21-12-13-23(33-28(21)31)27(19-8-4-3-5-9-19)34-29(38)25-14-20(30)15-36(25)26(37)16-35-17-32-22-10-6-7-11-24(22)35/h3-13,17-18,20,25,27H,14-16H2,1-2H3,(H,34,38)/t20-,25+,27+/m1/s1 NFMJCVNRRJSWAT-RAHIQWLESA-N 634940 US11814367, Compound 389 Glycogen [starch] synthase, liver >90290 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634940&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349708 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnnc1)c1ccccc1 InChI=1S/C24H26F2N6O2/c1-15(2)18-8-9-19(29-23(18)26)22(16-6-4-3-5-7-16)30-24(34)20-10-17(25)11-32(20)21(33)12-31-13-27-28-14-31/h3-9,13-15,17,20,22H,10-12H2,1-2H3,(H,30,34)/t17-,20+,22+/m1/s1 KGRVUYKUQBNXCE-AGHHOFFYSA-N 634941 US11814367, Compound 390 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634941&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349709 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cccn2c1n[nH]c2=O)c1ccccc1 634942 US11814367, Compound 391 Glycogen [starch] synthase, liver 89320 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634942&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349710 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ncc(n1)N(C)C)c1ccccc1 InChI=1S/C26H31F2N7O2/c1-16(2)19-10-11-20(30-25(19)28)24(17-8-6-5-7-9-17)31-26(37)21-12-18(27)14-34(21)23(36)15-35-29-13-22(32-35)33(3)4/h5-11,13,16,18,21,24H,12,14-15H2,1-4H3,(H,31,37)/t18-,21+,24+/m1/s1 QTSVMBLRZSEMNG-ZHRMCQFGSA-N 634943 US11814367, Compound 392 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634943&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349711 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(nn1)N(C)C)c1ccccc1 InChI=1S/C26H31F2N7O2/c1-16(2)19-10-11-20(29-25(19)28)24(17-8-6-5-7-9-17)30-26(37)21-12-18(27)13-35(21)23(36)15-34-14-22(31-32-34)33(3)4/h5-11,14,16,18,21,24H,12-13,15H2,1-4H3,(H,30,37)/t18-,21+,24+/m1/s1 KEEBYMBLLYQATM-ZHRMCQFGSA-N 634944 US11814367, Compound 393 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634944&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349712 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N(C)C)c1ccccc1 InChI=1S/C25H31F2N5O3/c1-15(2)18-10-11-19(29-23(18)27)22(16-8-6-5-7-9-16)30-24(34)20-12-17(26)14-32(20)21(33)13-28-25(35)31(3)4/h5-11,15,17,20,22H,12-14H2,1-4H3,(H,28,35)(H,30,34)/t17-,20+,22+/m1/s1 HVKKBBCCIFDZKX-AGHHOFFYSA-N 634945 US11814367, Compound 394 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634945&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349713 CNC(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C(C)C)c(F)n1 InChI=1S/C24H29F2N5O3/c1-14(2)17-9-10-18(29-22(17)26)21(15-7-5-4-6-8-15)30-23(33)19-11-16(25)13-31(19)20(32)12-28-24(34)27-3/h4-10,14,16,19,21H,11-13H2,1-3H3,(H,30,33)(H2,27,28,34)/t16-,19+,21+/m1/s1 UGTCUWUCHSSXJO-PBEJRMEISA-N 634946 US11814367, Compound 395 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634946&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349714 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(N)=O)c1ccccc1 InChI=1S/C23H27F2N5O3/c1-13(2)16-8-9-17(28-21(16)25)20(14-6-4-3-5-7-14)29-22(32)18-10-15(24)12-30(18)19(31)11-27-23(26)33/h3-9,13,15,18,20H,10-12H2,1-2H3,(H,29,32)(H3,26,27,33)/t15-,18+,20+/m1/s1 BMKKPFMGZCHYLW-BPAFIMBUSA-N 634947 US11814367, Compound 396 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634947&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349715 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1n[nH]c(=O)n1C)c1ccccc1 634949 US11814367, Compound 398 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634949&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349716 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CCC1)c1ccccc1 InChI=1S/C26H31F2N5O3/c1-16(2)19-9-10-20(30-24(19)28)23(17-7-4-3-5-8-17)31-25(35)21-13-18(27)15-33(21)22(34)14-29-26(36)32-11-6-12-32/h3-5,7-10,16,18,21,23H,6,11-15H2,1-2H3,(H,29,36)(H,31,35)/t18-,21+,23+/m1/s1 ZEYNGBROMVMGCE-JZWVFAODSA-N 634950 US11814367, Compound 399 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634950&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349717 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nnnc1C(F)F)c1ccccc1 InChI=1S/C24H25F4N7O2/c1-13(2)16-8-9-17(29-22(16)28)20(14-6-4-3-5-7-14)30-24(37)18-10-15(25)11-34(18)19(36)12-35-23(21(26)27)31-32-33-35/h3-9,13,15,18,20-21H,10-12H2,1-2H3,(H,30,37)/t15-,18+,20+/m1/s1 IYKFKSHCDFLOOM-BPAFIMBUSA-N 634951 US11814367, Compound 400 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634951&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349718 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nn(C)c(=O)o1)c1ccccc1 InChI=1S/C25H27F2N5O4/c1-14(2)17-9-10-18(28-23(17)27)22(15-7-5-4-6-8-15)29-24(34)19-11-16(26)13-32(19)21(33)12-20-30-31(3)25(35)36-20/h4-10,14,16,19,22H,11-13H2,1-3H3,(H,29,34)/t16-,19+,22+/m1/s1 KACGYALCMZPZTH-WVBUVRCRSA-N 634952 US11814367, Compound 401 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634952&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349719 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1noc(=O)n1C)c1ccccc1 InChI=1S/C25H27F2N5O4/c1-14(2)17-9-10-18(28-23(17)27)22(15-7-5-4-6-8-15)29-24(34)19-11-16(26)13-32(19)21(33)12-20-30-36-25(35)31(20)3/h4-10,14,16,19,22H,11-13H2,1-3H3,(H,29,34)/t16-,19+,22+/m1/s1 UYIJYFUYVHFSHY-WVBUVRCRSA-N 634953 US11814367, Compound 402 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634953&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349720 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1[nH]nnc1C(F)(F)F)c1ccccc1 634954 US11814367, Compound 403 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634954&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349721 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNc1ccnc(C)n1)c1ccccc1 InChI=1S/C27H30F2N6O2/c1-16(2)20-9-10-21(33-26(20)29)25(18-7-5-4-6-8-18)34-27(37)22-13-19(28)15-35(22)24(36)14-31-23-11-12-30-17(3)32-23/h4-12,16,19,22,25H,13-15H2,1-3H3,(H,34,37)(H,30,31,32)/t19-,22+,25+/m1/s1 LLXYIDOTWOZCGZ-WPWBMXPQSA-N 634955 US11814367, Compound 404 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634955&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349722 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@H](C)NC(=O)N(C)C)c1ccccc1 InChI=1S/C26H33F2N5O3/c1-15(2)19-11-12-20(30-23(19)28)22(17-9-7-6-8-10-17)31-24(34)21-13-18(27)14-33(21)25(35)16(3)29-26(36)32(4)5/h6-12,15-16,18,21-22H,13-14H2,1-5H3,(H,29,36)(H,31,34)/t16-,18+,21-,22-/m0/s1 BENDHJHCYHGXBI-REIYTJMXSA-N 634956 US11814367, Compound 405 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634956&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349723 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@H](C)NC(=O)N(C)C)c1ccccc1 InChI=1S/C26H33F2N5O3/c1-15(2)19-11-12-20(30-23(19)28)22(17-9-7-6-8-10-17)31-24(34)21-13-18(27)14-33(21)25(35)16(3)29-26(36)32(4)5/h6-12,15-16,18,21-22H,13-14H2,1-5H3,(H,29,36)(H,31,34)/t16-,18-,21+,22+/m1/s1 BENDHJHCYHGXBI-IIPCHUTBSA-N 634957 US11814367, Compound 406 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634957&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349724 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ncco1)c1ccccc1 InChI=1S/C25H26F2N4O3/c1-15(2)18-8-9-19(29-24(18)27)23(16-6-4-3-5-7-16)30-25(33)20-12-17(26)14-31(20)22(32)13-21-28-10-11-34-21/h3-11,15,17,20,23H,12-14H2,1-2H3,(H,30,33)/t17-,20+,23+/m1/s1 PICSGPUGWDZESP-MONBJTKQSA-N 634958 US11814367, Compound 407 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634958&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349725 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ncc(C)o1)c1ccccc1 InChI=1S/C26H28F2N4O3/c1-15(2)19-9-10-20(30-25(19)28)24(17-7-5-4-6-8-17)31-26(34)21-11-18(27)14-32(21)23(33)12-22-29-13-16(3)35-22/h4-10,13,15,18,21,24H,11-12,14H2,1-3H3,(H,31,34)/t18-,21+,24+/m1/s1 QUTVOHRTHWTQPK-ZHRMCQFGSA-N 634959 US11814367, Compound 408 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634959&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349726 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nc(C)co1)c1ccccc1 InChI=1S/C26H28F2N4O3/c1-15(2)19-9-10-20(30-25(19)28)24(17-7-5-4-6-8-17)31-26(34)21-11-18(27)13-32(21)23(33)12-22-29-16(3)14-35-22/h4-10,14-15,18,21,24H,11-13H2,1-3H3,(H,31,34)/t18-,21+,24+/m1/s1 GVTXCOXTMPQIKU-ZHRMCQFGSA-N 634960 US11814367, Compound 409 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634960&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349727 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CC(F)(F)C1)c1ccccc1 InChI=1S/C26H29F4N5O3/c1-15(2)18-8-9-19(32-23(18)28)22(16-6-4-3-5-7-16)33-24(37)20-10-17(27)12-35(20)21(36)11-31-25(38)34-13-26(29,30)14-34/h3-9,15,17,20,22H,10-14H2,1-2H3,(H,31,38)(H,33,37)/t17-,20+,22+/m1/s1 OIBFXDIQCCLTHZ-AGHHOFFYSA-N 634961 US11814367, Compound 410 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634961&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349728 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C)oc1=O)c1ccccc1 InChI=1S/C25H27F2N5O4/c1-14(2)18-9-10-19(28-23(18)27)22(16-7-5-4-6-8-16)29-24(34)20-11-17(26)12-31(20)21(33)13-32-25(35)36-15(3)30-32/h4-10,14,17,20,22H,11-13H2,1-3H3,(H,29,34)/t17-,20+,22+/m1/s1 WTXPSJTYTOSYIP-AGHHOFFYSA-N 634962 US11814367, Compound 411 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634962&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349729 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ncc(n1)N1CCC1)c1ccccc1 InChI=1S/C27H31F2N7O2/c1-17(2)20-9-10-21(31-26(20)29)25(18-7-4-3-5-8-18)32-27(38)22-13-19(28)15-35(22)24(37)16-36-30-14-23(33-36)34-11-6-12-34/h3-5,7-10,14,17,19,22,25H,6,11-13,15-16H2,1-2H3,(H,32,38)/t19-,22+,25+/m1/s1 HRAHCIHCOWHCRB-WPWBMXPQSA-N 634963 US11814367, Compound 412 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634963&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349730 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ncc(n1)N1CC(F)(F)C1)c1ccccc1 InChI=1S/C27H29F4N7O2/c1-16(2)19-8-9-20(33-25(19)29)24(17-6-4-3-5-7-17)34-26(40)21-10-18(28)12-37(21)23(39)13-38-32-11-22(35-38)36-14-27(30,31)15-36/h3-9,11,16,18,21,24H,10,12-15H2,1-2H3,(H,34,40)/t18-,21+,24+/m1/s1 RHWVYOAVFCOPSE-ZHRMCQFGSA-N 634964 US11814367, Compound 413 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634964&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349731 CCN(CC)c1cnn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C(C)C)c(F)n2)n1 InChI=1S/C28H35F2N7O2/c1-5-35(6-2)24-15-31-37(34-24)17-25(38)36-16-20(29)14-23(36)28(39)33-26(19-10-8-7-9-11-19)22-13-12-21(18(3)4)27(30)32-22/h7-13,15,18,20,23,26H,5-6,14,16-17H2,1-4H3,(H,33,39)/t20-,23+,26+/m1/s1 KULULFLLYSOPLS-SEIBCYHCSA-N 634965 US11814367, Compound 414 Glycogen [starch] synthase, liver 78660 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634965&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349732 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1[C@H]2C[C@H]2CN1C(=O)Cc1cnn[nH]1)c1ccccc1 634966 US11814367, Compound 415 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634966&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349733 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1CC[C@H](C)N1C(=O)Cc1cnn[nH]1)c1ccccc1 634967 US11814367, Compound 416 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634967&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349734 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cnc2ccccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C30H28F2N4O2/c31-22-15-27(36(16-22)28(37)17-35-18-33-25-8-4-5-9-26(25)35)30(38)34-29(20-6-2-1-3-7-20)21-12-13-23(19-10-11-19)24(32)14-21/h1-9,12-14,18-19,22,27,29H,10-11,15-17H2,(H,34,38)/t22-,27+,29+/m1/s1 ZKBRGQJIZMYLLB-RVBRUHEGSA-N 634968 US11814367, Compound 417 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634968&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349735 CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C23H24F2N2O2/c1-14(28)27-13-18(24)12-21(27)23(29)26-22(16-5-3-2-4-6-16)17-9-10-19(15-7-8-15)20(25)11-17/h2-6,9-11,15,18,21-22H,7-8,12-13H2,1H3,(H,26,29)/t18-,21+,22+/m1/s1 MISBRYMTSPRBLP-COPCDDAFSA-N 634969 US11814367, Compound 418 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634969&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349736 CC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C25H28FN3O3/c1-16(30)27-15-23(31)29-13-5-8-22(29)25(32)28-24(18-6-3-2-4-7-18)19-11-12-20(17-9-10-17)21(26)14-19/h2-4,6-7,11-12,14,17,22,24H,5,8-10,13,15H2,1H3,(H,27,30)(H,28,32)/t22-,24-/m0/s1 RRGJPOVTMDFGJD-UPVQGACJSA-N 634972 US11814367, Compound 421 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634972&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349737 F[C@@H]1C[C@H](N(C1)C(=O)CCc1ncco1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C27H27F2N3O3/c28-20-15-23(32(16-20)25(33)11-10-24-30-12-13-35-24)27(34)31-26(18-4-2-1-3-5-18)19-8-9-21(17-6-7-17)22(29)14-19/h1-5,8-9,12-14,17,20,23,26H,6-7,10-11,15-16H2,(H,31,34)/t20-,23+,26+/m1/s1 DKKFYWJJJCIRKJ-SEIBCYHCSA-N 634973 US11814367, Compound 422 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634973&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349738 F[C@@H]1C[C@H](N(C1)C(=O)CN1CCOC1=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C26H27F2N3O4/c27-19-13-22(31(14-19)23(32)15-30-10-11-35-26(30)34)25(33)29-24(17-4-2-1-3-5-17)18-8-9-20(16-6-7-16)21(28)12-18/h1-5,8-9,12,16,19,22,24H,6-7,10-11,13-15H2,(H,29,33)/t19-,22+,24+/m1/s1 PEVYRKHXMCHMHM-UCFCWBNQSA-N 634975 US11814367, Compound 424 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634975&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349739 CN1CCN(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)C1=O InChI=1S/C27H30F2N4O3/c1-31-11-12-32(27(31)36)16-24(34)33-15-20(28)14-23(33)26(35)30-25(18-5-3-2-4-6-18)19-9-10-21(17-7-8-17)22(29)13-19/h2-6,9-10,13,17,20,23,25H,7-8,11-12,14-16H2,1H3,(H,30,35)/t20-,23+,25+/m1/s1 GCABEMUGPKJAGO-PBXXJUDPSA-N 634976 US11814367, Compound 425 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634976&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349740 F[C@@H]1C[C@H](N(C1)C(=O)Cc1nnco1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C25H24F2N4O3/c26-18-11-21(31(13-18)23(32)12-22-30-28-14-34-22)25(33)29-24(16-4-2-1-3-5-16)17-8-9-19(15-6-7-15)20(27)10-17/h1-5,8-10,14-15,18,21,24H,6-7,11-13H2,(H,29,33)/t18-,21+,24+/m1/s1 CGKGBVIEBGVDGP-ZHRMCQFGSA-N 634977 US11814367, Compound 426 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634977&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349741 FC(F)c1nnc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)o1 InChI=1S/C26H24F4N4O3/c27-17-11-20(34(13-17)22(35)12-21-32-33-26(37-21)24(29)30)25(36)31-23(15-4-2-1-3-5-15)16-8-9-18(14-6-7-14)19(28)10-16/h1-5,8-10,14,17,20,23-24H,6-7,11-13H2,(H,31,36)/t17-,20+,23+/m1/s1 GQKKMGNYSFZXOR-MONBJTKQSA-N 634978 US11814367, Compound 427 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634978&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349742 F[C@@H]1C[C@H](N(C1)C(=O)Cc1nnc(o1)C(F)(F)F)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C26H23F5N4O3/c27-17-11-20(35(13-17)22(36)12-21-33-34-25(38-21)26(29,30)31)24(37)32-23(15-4-2-1-3-5-15)16-8-9-18(14-6-7-14)19(28)10-16/h1-5,8-10,14,17,20,23H,6-7,11-13H2,(H,32,37)/t17-,20+,23+/m1/s1 FWOKTFWHOODWCB-MONBJTKQSA-N 634979 US11814367, Compound 428 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634979&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349743 F[C@@H]1C[C@H](N(C1)C(=O)Cc1nnn[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 634981 US11814367, Compound 430 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634981&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349744 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cnnn1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C24H24F2N6O2/c25-18-11-21(32(12-18)22(33)13-31-14-27-29-30-31)24(34)28-23(16-4-2-1-3-5-16)17-8-9-19(15-6-7-15)20(26)10-17/h1-5,8-10,14-15,18,21,23H,6-7,11-13H2,(H,28,34)/t18-,21+,23+/m1/s1 DLEONLMYCCSZCO-JZWVFAODSA-N 634982 US11814367, Compound 431 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634982&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349745 Cc1nnnn1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C25H26F2N6O2/c1-15-29-30-31-33(15)14-23(34)32-13-19(26)12-22(32)25(35)28-24(17-5-3-2-4-6-17)18-9-10-20(16-7-8-16)21(27)11-18/h2-6,9-11,16,19,22,24H,7-8,12-14H2,1H3,(H,28,35)/t19-,22+,24+/m1/s1 VMMHHCVDTZTEER-UCFCWBNQSA-N 634983 US11814367, Compound 432 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634983 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634983&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349746 Cc1nnn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)n1 InChI=1S/C25H26F2N6O2/c1-15-29-31-33(30-15)14-23(34)32-13-19(26)12-22(32)25(35)28-24(17-5-3-2-4-6-17)18-9-10-20(16-7-8-16)21(27)11-18/h2-6,9-11,16,19,22,24H,7-8,12-14H2,1H3,(H,28,35)/t19-,22+,24+/m1/s1 CVXBTJCROTYKFL-UCFCWBNQSA-N 634984 US11814367, Compound 433 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634984 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634984&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349747 Cc1nnc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)[nH]1 634985 US11814367, Compound 434 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634985 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634985&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349748 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cccn1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C26H26F2N4O2/c27-20-14-23(32(15-20)24(33)16-31-12-4-11-29-31)26(34)30-25(18-5-2-1-3-6-18)19-9-10-21(17-7-8-17)22(28)13-19/h1-6,9-13,17,20,23,25H,7-8,14-16H2,(H,30,34)/t20-,23+,25+/m1/s1 PFABTZLILLOJFJ-PBXXJUDPSA-N 634986 US11814367, Compound 435 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634986 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634986&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349749 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ccn[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 634987 US11814367, Compound 436 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634987&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349750 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cn[nH]c1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 634988 US11814367, Compound 437 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634988&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349751 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cnn[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 634990 US11814367, Compound 439 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634990&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349752 CN(C)C(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C26H30F2N4O3/c1-31(2)26(35)29-14-23(33)32-15-19(27)13-22(32)25(34)30-24(17-6-4-3-5-7-17)18-10-11-20(16-8-9-16)21(28)12-18/h3-7,10-12,16,19,22,24H,8-9,13-15H2,1-2H3,(H,29,35)(H,30,34)/t19-,22+,24+/m1/s1 XPUUNOFZEYSUST-UCFCWBNQSA-N 634992 US11814367, Compound 441 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634992 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634992&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349753 Cc1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)c(=O)[nH]c1=O 634993 US11814367, Compound 442 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634993 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634993&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349754 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cccc2ncccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C32H29F2N3O2/c33-24-18-29(37(19-24)30(38)17-22-8-4-10-28-26(22)9-5-15-35-28)32(39)36-31(21-6-2-1-3-7-21)23-13-14-25(20-11-12-20)27(34)16-23/h1-10,13-16,20,24,29,31H,11-12,17-19H2,(H,36,39)/t24-,29+,31+/m1/s1 UUNMAPGDMYACLZ-AVKNQKEWSA-N 634994 US11814367, Compound 443 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634994&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349755 Cc1n[nH]c(C)c1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 634995 US11814367, Compound 444 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634995 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634995&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349756 CN1CCN(CC1)C(=O)OCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C29H34F2N4O4/c1-33-11-13-34(14-12-33)29(38)39-18-26(36)35-17-22(30)16-25(35)28(37)32-27(20-5-3-2-4-6-20)21-9-10-23(19-7-8-19)24(31)15-21/h2-6,9-10,15,19,22,25,27H,7-8,11-14,16-18H2,1H3,(H,32,37)/t22-,25+,27+/m1/s1 CMLOCODOOTXKBB-PWMMPXSUSA-N 634996 US11814367, Compound 445 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634996 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634996&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349757 F[C@@H]1C[C@H](N(C1)C(=O)COC(=O)N1CCN(CC(F)(F)F)CC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C30H33F5N4O4/c31-22-15-25(39(16-22)26(40)17-43-29(42)38-12-10-37(11-13-38)18-30(33,34)35)28(41)36-27(20-4-2-1-3-5-20)21-8-9-23(19-6-7-19)24(32)14-21/h1-5,8-9,14,19,22,25,27H,6-7,10-13,15-18H2,(H,36,41)/t22-,25+,27+/m1/s1 BWXMANLFGKYEIR-PWMMPXSUSA-N 634997 US11814367, Compound 446 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634997 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634997&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349758 F[C@@H]1C[C@H](N(C1)C(=O)COC(=O)N1CCN(CC2CC2)CC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C32H38F2N4O4/c33-25-17-28(38(19-25)29(39)20-42-32(41)37-14-12-36(13-15-37)18-21-6-7-21)31(40)35-30(23-4-2-1-3-5-23)24-10-11-26(22-8-9-22)27(34)16-24/h1-5,10-11,16,21-22,25,28,30H,6-9,12-15,17-20H2,(H,35,40)/t25-,28+,30+/m1/s1 QRCYRMAIZMXCOW-YRGIIOSFSA-N 634998 US11814367, Compound 447 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634998 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634998&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349759 COCCN1CCN(CC1)C(=O)OCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C31H38F2N4O5/c1-41-16-15-35-11-13-36(14-12-35)31(40)42-20-28(38)37-19-24(32)18-27(37)30(39)34-29(22-5-3-2-4-6-22)23-9-10-25(21-7-8-21)26(33)17-23/h2-6,9-10,17,21,24,27,29H,7-8,11-16,18-20H2,1H3,(H,34,39)/t24-,27+,29+/m1/s1 PGLWXBCRVHBTLT-QXGAZULMSA-N 634999 US11814367, Compound 448 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634999&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349760 Cn1c(=O)ccn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)c1=O InChI=1S/C28H28F2N4O4/c1-32-24(35)11-12-33(28(32)38)16-25(36)34-15-20(29)14-23(34)27(37)31-26(18-5-3-2-4-6-18)19-9-10-21(17-7-8-17)22(30)13-19/h2-6,9-13,17,20,23,26H,7-8,14-16H2,1H3,(H,31,37)/t20-,23+,26+/m1/s1 JBYNGEHWUNOOFI-SEIBCYHCSA-N 635000 US11814367, Compound 449 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635000 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635000&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349761 F[C@@H]1C[C@H](N(C1)C(=O)Cn1nnc2ccccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C29H27F2N5O2/c30-21-15-26(35(16-21)27(37)17-36-25-9-5-4-8-24(25)33-34-36)29(38)32-28(19-6-2-1-3-7-19)20-12-13-22(18-10-11-18)23(31)14-20/h1-9,12-14,18,21,26,28H,10-11,15-17H2,(H,32,38)/t21-,26+,28+/m1/s1 PQUKGVNJLPDIEE-LARUCZGFSA-N 635001 US11814367, Compound 450 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635001 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635001&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349762 F[C@@H]1C[C@H](N(C1)C(=O)COC(=O)N1CCC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C27H29F2N3O4/c28-20-14-23(32(15-20)24(33)16-36-27(35)31-11-4-12-31)26(34)30-25(18-5-2-1-3-6-18)19-9-10-21(17-7-8-17)22(29)13-19/h1-3,5-6,9-10,13,17,20,23,25H,4,7-8,11-12,14-16H2,(H,30,34)/t20-,23+,25+/m1/s1 ZBJKDFXHZAMESX-PBXXJUDPSA-N 635002 US11814367, Compound 451 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635002&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349763 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CCOCC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C28H32F2N4O4/c29-21-15-24(34(17-21)25(35)16-31-28(37)33-10-12-38-13-11-33)27(36)32-26(19-4-2-1-3-5-19)20-8-9-22(18-6-7-18)23(30)14-20/h1-5,8-9,14,18,21,24,26H,6-7,10-13,15-17H2,(H,31,37)(H,32,36)/t21-,24+,26+/m1/s1 KUPNFAIMJFLNMF-DSBYRVASSA-N 635003 US11814367, Compound 452 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635003 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635003&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349764 F[C@@H]1C[C@H](N(C1)C(=O)CN1Cc2ccccc2C1=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C31H29F2N3O3/c32-23-15-27(36(17-23)28(37)18-35-16-22-8-4-5-9-25(22)31(35)39)30(38)34-29(20-6-2-1-3-7-20)21-12-13-24(19-10-11-19)26(33)14-21/h1-9,12-14,19,23,27,29H,10-11,15-18H2,(H,34,38)/t23-,27+,29+/m1/s1 LGXYIJYTQBHANL-OVTKCHPXSA-N 635004 US11814367, Compound 453 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635004&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349765 F[C@@H]1C[C@H](N(C1)C(=O)CN1C(=O)Cc2ccccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C31H29F2N3O3/c32-23-16-27(35(17-23)29(38)18-36-26-9-5-4-8-21(26)15-28(36)37)31(39)34-30(20-6-2-1-3-7-20)22-12-13-24(19-10-11-19)25(33)14-22/h1-9,12-14,19,23,27,30H,10-11,15-18H2,(H,34,39)/t23-,27+,30+/m1/s1 HJLWLJWWPPWQIP-MGTSJQRLSA-N 635005 US11814367, Compound 454 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635005 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635005&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349766 CN1C(=O)C(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)c2ccccc12 InChI=1S/C32H31F2N3O3/c1-36-27-10-6-5-9-24(27)25(32(36)40)17-29(38)37-18-22(33)16-28(37)31(39)35-30(20-7-3-2-4-8-20)21-13-14-23(19-11-12-19)26(34)15-21/h2-10,13-15,19,22,25,28,30H,11-12,16-18H2,1H3,(H,35,39)/t22-,25?,28+,30+/m1/s1 XCMZUBWEVJWVHV-NYPWMIJKSA-N 635006 US11814367, Compound 455 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635006 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635006&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349767 F[C@@H]1C[C@H](N(C1)C(=O)Cn1c2ccccc2[nH]c1=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 635007 US11814367, Compound 456 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635007 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635007&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349768 Cn1c2ccccc2n(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)c1=O InChI=1S/C31H30F2N4O3/c1-35-25-9-5-6-10-26(25)37(31(35)40)18-28(38)36-17-22(32)16-27(36)30(39)34-29(20-7-3-2-4-8-20)21-13-14-23(19-11-12-19)24(33)15-21/h2-10,13-15,19,22,27,29H,11-12,16-18H2,1H3,(H,34,39)/t22-,27+,29+/m1/s1 ZMZFBTMVNAEKSD-RVBRUHEGSA-N 635008 US11814367, Compound 457 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635008&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349769 F[C@@H]1C[C@H](N(C1)C(=O)Cc1n[nH]c2ccccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 635009 US11814367, Compound 458 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635009 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635009&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349770 Cn1nc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)c2ccccc12 InChI=1S/C31H30F2N4O2/c1-36-27-10-6-5-9-24(27)26(35-36)17-29(38)37-18-22(32)16-28(37)31(39)34-30(20-7-3-2-4-8-20)21-13-14-23(19-11-12-19)25(33)15-21/h2-10,13-15,19,22,28,30H,11-12,16-18H2,1H3,(H,34,39)/t22-,28+,30+/m1/s1 HBWJATWQSJOGFG-JPDBUEETSA-N 635010 US11814367, Compound 459 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635010&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349771 Cn1c(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)cc2ccccc12 InChI=1S/C32H31F2N3O2/c1-36-25(15-22-9-5-6-10-28(22)36)18-30(38)37-19-24(33)17-29(37)32(39)35-31(21-7-3-2-4-8-21)23-13-14-26(20-11-12-20)27(34)16-23/h2-10,13-16,20,24,29,31H,11-12,17-19H2,1H3,(H,35,39)/t24-,29+,31+/m1/s1 BGRIEMIMNLWMCR-AVKNQKEWSA-N 635013 US11814367, Compound 462 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635013&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349772 Cn1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)c2ccccc12 InChI=1S/C32H31F2N3O2/c1-36-18-23(26-9-5-6-10-28(26)36)16-30(38)37-19-24(33)17-29(37)32(39)35-31(21-7-3-2-4-8-21)22-13-14-25(20-11-12-20)27(34)15-22/h2-10,13-15,18,20,24,29,31H,11-12,16-17,19H2,1H3,(H,35,39)/t24-,29+,31+/m1/s1 AHLUJRNMPVGALH-AVKNQKEWSA-N 635014 US11814367, Compound 463 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635014 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635014&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349773 Cc1nc2ccccc2n1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C31H30F2N4O2/c1-19-34-26-9-5-6-10-27(26)36(19)18-29(38)37-17-23(32)16-28(37)31(39)35-30(21-7-3-2-4-8-21)22-13-14-24(20-11-12-20)25(33)15-22/h2-10,13-15,20,23,28,30H,11-12,16-18H2,1H3,(H,35,39)/t23-,28+,30+/m1/s1 YCFSWUXZHDAXNR-SLTKKEMYSA-N 635015 US11814367, Compound 464 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635015 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635015&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349774 F[C@@H]1C[C@H](N(C1)C(=O)CN1CCNCC1=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C27H30F2N4O3/c28-20-13-23(33(15-20)25(35)16-32-11-10-30-14-24(32)34)27(36)31-26(18-4-2-1-3-5-18)19-8-9-21(17-6-7-17)22(29)12-19/h1-5,8-9,12,17,20,23,26,30H,6-7,10-11,13-16H2,(H,31,36)/t20-,23+,26+/m1/s1 ZUYDKDHASRBWLY-SEIBCYHCSA-N 635016 US11814367, Compound 465 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635016 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635016&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349775 F[C@@H]1C[C@H](N(C1)C(=O)CN1CCN(CC(F)(F)F)CC1=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C29H31F5N4O3/c30-21-13-24(38(14-21)26(40)16-37-11-10-36(15-25(37)39)17-29(32,33)34)28(41)35-27(19-4-2-1-3-5-19)20-8-9-22(18-6-7-18)23(31)12-20/h1-5,8-9,12,18,21,24,27H,6-7,10-11,13-17H2,(H,35,41)/t21-,24+,27+/m1/s1 MYJANAFKDTWPLL-QURRFSBHSA-N 635017 US11814367, Compound 466 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635017 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635017&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349776 F[C@@H]1C[C@H](N(C1)C(=O)CC1C(=O)Nc2ccccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C31H29F2N3O3/c32-21-15-27(36(17-21)28(37)16-24-23-8-4-5-9-26(23)34-30(24)38)31(39)35-29(19-6-2-1-3-7-19)20-12-13-22(18-10-11-18)25(33)14-20/h1-9,12-14,18,21,24,27,29H,10-11,15-17H2,(H,34,38)(H,35,39)/t21-,24?,27+,29+/m1/s1 MFJUIOSWCZNRRB-MGRUEMFBSA-N 635018 US11814367, Compound 467 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635018&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349777 Cc1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)cn1 InChI=1S/C27H28F2N4O2/c1-17-13-32(16-30-17)15-25(34)33-14-21(28)12-24(33)27(35)31-26(19-5-3-2-4-6-19)20-9-10-22(18-7-8-18)23(29)11-20/h2-6,9-11,13,16,18,21,24,26H,7-8,12,14-15H2,1H3,(H,31,35)/t21-,24+,26+/m1/s1 DNQUTROYZFEJSZ-DSBYRVASSA-N 635019 US11814367, Compound 468 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635019&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349778 CCn1cc(NCC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)nn1 InChI=1S/C27H30F2N6O2/c1-2-34-16-24(32-33-34)30-14-25(36)35-15-20(28)13-23(35)27(37)31-26(18-6-4-3-5-7-18)19-10-11-21(17-8-9-17)22(29)12-19/h3-7,10-12,16-17,20,23,26,30H,2,8-9,13-15H2,1H3,(H,31,37)/t20-,23+,26+/m1/s1 YGOJEKGXEIBABN-SEIBCYHCSA-N 635020 US11814367, Compound 469 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635020 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635020&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349779 CCn1ncc(NCC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)n1 InChI=1S/C27H30F2N6O2/c1-2-35-31-14-24(33-35)30-15-25(36)34-16-20(28)13-23(34)27(37)32-26(18-6-4-3-5-7-18)19-10-11-21(17-8-9-17)22(29)12-19/h3-7,10-12,14,17,20,23,26H,2,8-9,13,15-16H2,1H3,(H,30,33)(H,32,37)/t20-,23+,26+/m1/s1 ZVKLHMNPCAYHME-SEIBCYHCSA-N 635021 US11814367, Compound 470 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635021 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635021&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349780 F[C@@H]1C[C@H](N(C1)C(=O)CNc1cnccn1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C27H27F2N5O2/c28-20-13-23(34(16-20)25(35)15-32-24-14-30-10-11-31-24)27(36)33-26(18-4-2-1-3-5-18)19-8-9-21(17-6-7-17)22(29)12-19/h1-5,8-12,14,17,20,23,26H,6-7,13,15-16H2,(H,31,32)(H,33,36)/t20-,23+,26+/m1/s1 CTZJQSPIYHLDOL-SEIBCYHCSA-N 635022 US11814367, Compound 471 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635022 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635022&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349781 Cc1nccc(NCC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)n1 InChI=1S/C28H29F2N5O2/c1-17-31-12-11-25(33-17)32-15-26(36)35-16-21(29)14-24(35)28(37)34-27(19-5-3-2-4-6-19)20-9-10-22(18-7-8-18)23(30)13-20/h2-6,9-13,18,21,24,27H,7-8,14-16H2,1H3,(H,34,37)(H,31,32,33)/t21-,24+,27+/m1/s1 FUROKHYLFDDURF-QURRFSBHSA-N 635023 US11814367, Compound 472 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635023&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349782 CCn1ncc(n1)N(C)CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C28H32F2N6O2/c1-3-36-31-15-25(33-36)34(2)17-26(37)35-16-21(29)14-24(35)28(38)32-27(19-7-5-4-6-8-19)20-11-12-22(18-9-10-18)23(30)13-20/h4-8,11-13,15,18,21,24,27H,3,9-10,14,16-17H2,1-2H3,(H,32,38)/t21-,24+,27+/m1/s1 XMGGWZNBVGGLLK-QURRFSBHSA-N 635025 US11814367, Compound 474 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635025&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349783 CN(CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1)c1cnccn1 InChI=1S/C28H29F2N5O2/c1-34(25-15-31-11-12-32-25)17-26(36)35-16-21(29)14-24(35)28(37)33-27(19-5-3-2-4-6-19)20-9-10-22(18-7-8-18)23(30)13-20/h2-6,9-13,15,18,21,24,27H,7-8,14,16-17H2,1H3,(H,33,37)/t21-,24+,27+/m1/s1 MNIRAHXNVMLJHJ-QURRFSBHSA-N 635026 US11814367, Compound 475 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635026&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349784 CN(CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1)c1cncc(C)n1 InChI=1S/C29H31F2N5O2/c1-18-14-32-15-26(33-18)35(2)17-27(37)36-16-22(30)13-25(36)29(38)34-28(20-6-4-3-5-7-20)21-10-11-23(19-8-9-19)24(31)12-21/h3-7,10-12,14-15,19,22,25,28H,8-9,13,16-17H2,1-2H3,(H,34,38)/t22-,25+,28+/m1/s1 HKGSTAMUMZVVFN-ATILKMQGSA-N 635027 US11814367, Compound 476 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635027&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349785 Cc1ccc2c(CC(=O)N3C[C@H](F)C[C@H]3C(=O)N[C@@H](c3ccccc3)c3ccc(C4CC4)c(F)c3)cccc2n1 InChI=1S/C33H31F2N3O2/c1-20-10-14-27-23(8-5-9-29(27)36-20)17-31(39)38-19-25(34)18-30(38)33(40)37-32(22-6-3-2-4-7-22)24-13-15-26(21-11-12-21)28(35)16-24/h2-10,13-16,21,25,30,32H,11-12,17-19H2,1H3,(H,37,40)/t25-,30+,32+/m1/s1 NCGHAEOVJJRJMG-HFYAYSLXSA-N 635028 US11814367, Compound 477 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635028&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349786 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ccc2ncnn2c1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C29H27F2N5O2/c30-22-14-25(35(16-22)27(37)12-18-6-11-26-32-17-33-36(26)15-18)29(38)34-28(20-4-2-1-3-5-20)21-9-10-23(19-7-8-19)24(31)13-21/h1-6,9-11,13,15,17,19,22,25,28H,7-8,12,14,16H2,(H,34,38)/t22-,25+,28+/m1/s1 BBHPOXMCGUGXPB-ATILKMQGSA-N 635029 US11814367, Compound 478 Glycogen [starch] synthase, liver 68220 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635029&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349787 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cnc2ccccn12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C30H28F2N4O2/c31-22-15-26(36(18-22)28(37)16-23-17-33-27-8-4-5-13-35(23)27)30(38)34-29(20-6-2-1-3-7-20)21-11-12-24(19-9-10-19)25(32)14-21/h1-8,11-14,17,19,22,26,29H,9-10,15-16,18H2,(H,34,38)/t22-,26+,29+/m1/s1 HEMVKAPAFRPZCQ-DVTKYRPYSA-N 635030 US11814367, Compound 479 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635030&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349788 Cc1ccc2cc(CC(=O)N3C[C@H](F)C[C@H]3C(=O)N[C@@H](c3ccccc3)c3ccc(C4CC4)c(F)c3)ccc2n1 InChI=1S/C33H31F2N3O2/c1-20-7-9-24-15-21(8-14-29(24)36-20)16-31(39)38-19-26(34)18-30(38)33(40)37-32(23-5-3-2-4-6-23)25-12-13-27(22-10-11-22)28(35)17-25/h2-9,12-15,17,22,26,30,32H,10-11,16,18-19H2,1H3,(H,37,40)/t26-,30+,32+/m1/s1 CXZJHAKKLHIUSJ-XKLAPMPNSA-N 635031 US11814367, Compound 480 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635031&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349789 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cnnc1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C25H25F2N5O2/c26-19-11-22(32(12-19)23(33)13-31-14-28-29-15-31)25(34)30-24(17-4-2-1-3-5-17)18-8-9-20(16-6-7-16)21(27)10-18/h1-5,8-10,14-16,19,22,24H,6-7,11-13H2,(H,30,34)/t19-,22+,24+/m1/s1 JVCLPOWNPWBXKK-UCFCWBNQSA-N 635032 US11814367, Compound 481 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635032&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349790 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cccn2c1n[nH]c2=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 635033 US11814367, Compound 482 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635033&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349791 CN(C)c1cnn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)n1 InChI=1S/C27H30F2N6O2/c1-33(2)24-14-30-35(32-24)16-25(36)34-15-20(28)13-23(34)27(37)31-26(18-6-4-3-5-7-18)19-10-11-21(17-8-9-17)22(29)12-19/h3-7,10-12,14,17,20,23,26H,8-9,13,15-16H2,1-2H3,(H,31,37)/t20-,23+,26+/m1/s1 BWMVWGJCSOQTQZ-SEIBCYHCSA-N 635034 US11814367, Compound 483 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635034&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349792 CN(C)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)nn1 InChI=1S/C27H30F2N6O2/c1-33(2)24-15-34(32-31-24)16-25(36)35-14-20(28)13-23(35)27(37)30-26(18-6-4-3-5-7-18)19-10-11-21(17-8-9-17)22(29)12-19/h3-7,10-12,15,17,20,23,26H,8-9,13-14,16H2,1-2H3,(H,30,37)/t20-,23+,26+/m1/s1 OBNLIDLLFKCTKB-SEIBCYHCSA-N 635035 US11814367, Compound 484 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635035&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349793 CC(C)(C)OC(=O)NCc1nnc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)c2)o1 InChI=1S/C31H35F2N5O5/c1-31(2,3)43-30(41)34-16-26-37-36-25(42-26)15-27(39)38-17-21(32)14-24(38)29(40)35-28(19-7-5-4-6-8-19)20-11-12-22(18-9-10-18)23(33)13-20/h4-8,11-13,18,21,24,28H,9-10,14-17H2,1-3H3,(H,34,41)(H,35,40)/t21-,24+,28+/m1/s1 XKLCMTYUOKITDJ-NZRVCZAQSA-N 635036 US11814367, Compound 485 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635036&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349794 CN1CCN(CC1)C(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C29H35F2N5O3/c1-34-11-13-35(14-12-34)29(39)32-17-26(37)36-18-22(30)16-25(36)28(38)33-27(20-5-3-2-4-6-20)21-9-10-23(19-7-8-19)24(31)15-21/h2-6,9-10,15,19,22,25,27H,7-8,11-14,16-18H2,1H3,(H,32,39)(H,33,38)/t22-,25+,27+/m1/s1 CJETYKRIKSWIDQ-PWMMPXSUSA-N 635037 US11814367, Compound 486 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635037&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349795 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CCN(CC(F)(F)F)CC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C30H34F5N5O3/c31-22-15-25(40(17-22)26(41)16-36-29(43)39-12-10-38(11-13-39)18-30(33,34)35)28(42)37-27(20-4-2-1-3-5-20)21-8-9-23(19-6-7-19)24(32)14-21/h1-5,8-9,14,19,22,25,27H,6-7,10-13,15-18H2,(H,36,43)(H,37,42)/t22-,25+,27+/m1/s1 NBKBTUKSHARRLW-PWMMPXSUSA-N 635038 US11814367, Compound 487 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635038&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349796 COCCN1CCN(CC1)C(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C31H39F2N5O4/c1-42-16-15-36-11-13-37(14-12-36)31(41)34-19-28(39)38-20-24(32)18-27(38)30(40)35-29(22-5-3-2-4-6-22)23-9-10-25(21-7-8-21)26(33)17-23/h2-6,9-10,17,21,24,27,29H,7-8,11-16,18-20H2,1H3,(H,34,41)(H,35,40)/t24-,27+,29+/m1/s1 DKKXYBBEHJFYBT-QXGAZULMSA-N 635039 US11814367, Compound 488 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635039&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349797 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CCN(CC2CC2)CC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C32H39F2N5O3/c33-25-17-28(39(20-25)29(40)18-35-32(42)38-14-12-37(13-15-38)19-21-6-7-21)31(41)36-30(23-4-2-1-3-5-23)24-10-11-26(22-8-9-22)27(34)16-24/h1-5,10-11,16,21-22,25,28,30H,6-9,12-15,17-20H2,(H,35,42)(H,36,41)/t25-,28+,30+/m1/s1 FCUUZIXSYPIBFN-YRGIIOSFSA-N 635041 US11814367, Compound 490 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635041&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349798 F[C@@H]1C[C@H](N(C1)C(=O)Cc1n[nH]c(=O)[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C25H23F2N5O3/c26-17-11-20(32(13-17)22(33)12-21-28-25(35)31-30-21)24(34)29-23(15-4-2-1-3-5-15)16-8-9-18(14-6-7-14)19(27)10-16/h1-5,8-10,14,17,20,23H,6-7,11-13H2,(H,29,34)/t17-,20+,23+/m1/s1 DOULLJDHBYPPFP-MONBJTKQSA-N 635042 US11814367, Compound 491 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635042&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349799 F[C@@H]1C[C@H](N(C1)C(=O)Cc1noc(=O)[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 635043 US11814367, Compound 492 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635043&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349800 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CC(F)(F)C1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C27H28F4N4O3/c28-19-11-22(35(13-19)23(36)12-32-26(38)34-14-27(30,31)15-34)25(37)33-24(17-4-2-1-3-5-17)18-8-9-20(16-6-7-16)21(29)10-18/h1-5,8-10,16,19,22,24H,6-7,11-15H2,(H,32,38)(H,33,37)/t19-,22+,24+/m1/s1 GYNHZMJWMHDLAE-UCFCWBNQSA-N 635046 US11814367, Compound 495 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635046 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635046&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349801 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CC(C1)C(F)(F)F)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1 InChI=1S/C28H29F5N4O3/c29-20-11-23(37(15-20)24(38)12-34-27(40)36-13-19(14-36)28(31,32)33)26(39)35-25(17-4-2-1-3-5-17)18-8-9-21(16-6-7-16)22(30)10-18/h1-5,8-10,16,19-20,23,25H,6-7,11-15H2,(H,34,40)(H,35,39)/t20-,23+,25+/m1/s1 CMVPKERYJRNYAU-PBXXJUDPSA-N 635047 US11814367, Compound 496 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635047 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635047&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349802 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cnn[nH]1)C(=O)NC(c1ccccc1)c1ccc(cn1)C1CC1 635048 US11814367, Compound 497::US11814367, Compound 498 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635048 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635048&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349803 CCn1c(=O)c(C)cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)n2)c1=O InChI=1S/C30H31F4N5O4/c1-3-38-28(42)17(2)14-37(29(38)43)16-24(40)39-15-20(31)11-23(39)27(41)36-25(18-7-5-4-6-8-18)22-10-9-21(26(32)35-22)19-12-30(33,34)13-19/h4-10,14,19-20,23,25H,3,11-13,15-16H2,1-2H3,(H,36,41)/t20-,23+,25+/m1/s1 RKXLMTOUUNAEPD-PBXXJUDPSA-N 635052 US11814367, Compound 501 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635052 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635052&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349804 Cc1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)n2)c(=O)o1 InChI=1S/C26H25F4N5O4/c1-14-33-35(25(38)39-14)13-21(36)34-12-17(27)9-20(34)24(37)32-22(15-5-3-2-4-6-15)19-8-7-18(23(28)31-19)16-10-26(29,30)11-16/h2-8,16-17,20,22H,9-13H2,1H3,(H,32,37)/t17-,20+,22+/m1/s1 OQBGOXVADHOIBZ-AGHHOFFYSA-N 635053 US11814367, Compound 502 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635053&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349805 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CCC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 InChI=1S/C27H29F4N5O3/c28-18-11-21(36(15-18)22(37)14-32-26(39)35-9-4-10-35)25(38)34-23(16-5-2-1-3-6-16)20-8-7-19(24(29)33-20)17-12-27(30,31)13-17/h1-3,5-8,17-18,21,23H,4,9-15H2,(H,32,39)(H,34,38)/t18-,21+,23+/m1/s1 PVTQAUMSTUYZME-JZWVFAODSA-N 635054 US11814367, Compound 503 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635054 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635054&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349806 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cnc2ccccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 InChI=1S/C30H27F4N5O2/c31-20-12-25(39(15-20)26(40)16-38-17-35-22-8-4-5-9-24(22)38)29(41)37-27(18-6-2-1-3-7-18)23-11-10-21(28(32)36-23)19-13-30(33,34)14-19/h1-11,17,19-20,25,27H,12-16H2,(H,37,41)/t20-,25+,27+/m1/s1 MQTYAVBLUZSAPO-RAHIQWLESA-N 635055 US11814367, Compound 504 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635055 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635055&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349807 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ncco1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 InChI=1S/C26H24F4N4O3/c27-17-10-20(34(14-17)22(35)11-21-31-8-9-37-21)25(36)33-23(15-4-2-1-3-5-15)19-7-6-18(24(28)32-19)16-12-26(29,30)13-16/h1-9,16-17,20,23H,10-14H2,(H,33,36)/t17-,20+,23+/m1/s1 NACCXFBCZGSBSL-MONBJTKQSA-N 635056 US11814367, Compound 505 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635056 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635056&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349808 Cc1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)n2)c(=O)[nH]c1=O 635057 US11814367, Compound 506 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635057&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349809 CN(C)C(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 InChI=1S/C26H29F4N5O3/c1-34(2)25(38)31-13-21(36)35-14-17(27)10-20(35)24(37)33-22(15-6-4-3-5-7-15)19-9-8-18(23(28)32-19)16-11-26(29,30)12-16/h3-9,16-17,20,22H,10-14H2,1-2H3,(H,31,38)(H,33,37)/t17-,20+,22+/m1/s1 UKWNSNIMSKRQOG-AGHHOFFYSA-N 635058 US11814367, Compound 507 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635058&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349810 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cnn[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 635059 US11814367, Compound 508 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635059&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349811 Cc1cnc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)n2)o1 InChI=1S/C27H26F4N4O3/c1-15-13-32-22(38-15)10-23(36)35-14-18(28)9-21(35)26(37)34-24(16-5-3-2-4-6-16)20-8-7-19(25(29)33-20)17-11-27(30,31)12-17/h2-8,13,17-18,21,24H,9-12,14H2,1H3,(H,34,37)/t18-,21+,24+/m1/s1 FPCXWAJLYWVBCG-ZHRMCQFGSA-N 635060 US11814367, Compound 509 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635060 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635060&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349812 F[C@@H]1C[C@H](N(C1)C(=O)Cc1[nH]nnc1C(F)(F)F)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 635061 US11814367, Compound 510 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635061&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349813 Cc1coc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)n2)n1 InChI=1S/C27H26F4N4O3/c1-15-14-38-22(32-15)10-23(36)35-13-18(28)9-21(35)26(37)34-24(16-5-3-2-4-6-16)20-8-7-19(25(29)33-20)17-11-27(30,31)12-17/h2-8,14,17-18,21,24H,9-13H2,1H3,(H,34,37)/t18-,21+,24+/m1/s1 NAXNBMWIIKEDGV-ZHRMCQFGSA-N 635062 US11814367, Compound 511 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635062&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349814 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CC(F)(F)C1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 InChI=1S/C27H27F6N5O3/c28-17-8-20(38(12-17)21(39)11-34-25(41)37-13-27(32,33)14-37)24(40)36-22(15-4-2-1-3-5-15)19-7-6-18(23(29)35-19)16-9-26(30,31)10-16/h1-7,16-17,20,22H,8-14H2,(H,34,41)(H,36,40)/t17-,20+,22+/m1/s1 MMCLWMZXTAUPBF-AGHHOFFYSA-N 635063 US11814367, Compound 512 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635063&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349815 FC(F)c1nnnn1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 InChI=1S/C25H23F6N7O2/c26-15-8-18(37(11-15)19(39)12-38-23(21(27)28)34-35-36-38)24(40)33-20(13-4-2-1-3-5-13)17-7-6-16(22(29)32-17)14-9-25(30,31)10-14/h1-7,14-15,18,20-21H,8-12H2,(H,33,40)/t15-,18+,20+/m1/s1 JMHCVEKKTBDSJH-BPAFIMBUSA-N 635064 US11814367, Compound 513 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635064 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635064&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349816 F[C@@H]1C[C@H](N(C1)C(=O)Cn1ccc(=O)[nH]c1=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 635065 US11814367, Compound 514 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635065&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349817 CCn1c(=O)ccn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)n2)c1=O InChI=1S/C29H29F4N5O4/c1-2-37-23(39)10-11-36(28(37)42)16-24(40)38-15-19(30)12-22(38)27(41)35-25(17-6-4-3-5-7-17)21-9-8-20(26(31)34-21)18-13-29(32,33)14-18/h3-11,18-19,22,25H,2,12-16H2,1H3,(H,35,41)/t19-,22+,25+/m1/s1 IMJIZDNFMQGNDO-WPWBMXPQSA-N 635066 US11814367, Compound 515 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635066&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349818 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ccc(=O)[nH]c1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 635067 US11814367, Compound 516 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635067&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349819 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ccc[nH]c1=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 635068 US11814367, Compound 517 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635068&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349820 CCn1c(=O)c(C)cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)n2)c1=O InChI=1S/C30H31F4N5O4/c1-3-38-28(42)17(2)14-37(29(38)43)16-24(40)39-15-20(31)11-23(39)27(41)36-25(18-7-5-4-6-8-18)22-10-9-21(26(32)35-22)19-12-30(33,34)13-19/h4-10,14,19-20,23,25H,3,11-13,15-16H2,1-2H3,(H,36,41)/t20-,23+,25-/m1/s1 RKXLMTOUUNAEPD-JHMXWDHMSA-N 635069 US11814367, Compound 518 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635069&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349821 CCn1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)n2)ccc1=O InChI=1S/C30H30F4N4O3/c1-2-37-16-18(8-11-25(37)39)12-26(40)38-17-21(31)13-24(38)29(41)36-27(19-6-4-3-5-7-19)23-10-9-22(28(32)35-23)20-14-30(33,34)15-20/h3-11,16,20-21,24,27H,2,12-15,17H2,1H3,(H,36,41)/t21-,24+,27+/m1/s1 BVXBUTWPSLBZGE-QURRFSBHSA-N 635070 US11814367, Compound 519 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635070&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349822 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ccc(=O)[nH]c1)C(=O)N[C@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)n1 635071 US11814367, Compound 520 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635071&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349823 Cc1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)n2)c[nH]c1=O 635073 US11814367, Compound 522 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635073&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349824 CN(C)C(=O)NCC(=O)N1C[C@H](F)CC1C(=O)N[C@@H](c1ccccc1)c1ccc(cn1)C1CC(F)(F)C1 InChI=1S/C26H30F3N5O3/c1-33(2)25(37)31-14-22(35)34-15-19(27)10-21(34)24(36)32-23(16-6-4-3-5-7-16)20-9-8-17(13-30-20)18-11-26(28,29)12-18/h3-9,13,18-19,21,23H,10-12,14-15H2,1-2H3,(H,31,37)(H,32,36)/t19-,21?,23+/m1/s1 AGDTXEXHEHJSMA-DHGPAQJLSA-N 635083 US11814367, Compound 532 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635083&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349825 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CCC1)C(=O)N[C@@H](c1ccccc1)c1ccc(cn1)C1CC(F)(F)C1 InChI=1S/C27H30F3N5O3/c28-20-11-22(35(16-20)23(36)15-32-26(38)34-9-4-10-34)25(37)33-24(17-5-2-1-3-6-17)21-8-7-18(14-31-21)19-12-27(29,30)13-19/h1-3,5-8,14,19-20,22,24H,4,9-13,15-16H2,(H,32,38)(H,33,37)/t20-,22+,24+/m1/s1 YCEANMBZKLTEJK-SFLYRZDNSA-N 635084 US11814367, Compound 533 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635084&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349826 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cnn[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(cn1)C1CC(F)(F)C1 635085 US11814367, Compound 534 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635085&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349827 Cc1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cn2)C2CC(F)(F)C2)c(=O)[nH]c1=O 635086 US11814367, Compound 535 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635086&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349828 Cc1cnc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cn2)C2CC(F)(F)C2)o1 InChI=1S/C27H27F3N4O3/c1-16-13-32-23(37-16)10-24(35)34-15-20(28)9-22(34)26(36)33-25(17-5-3-2-4-6-17)21-8-7-18(14-31-21)19-11-27(29,30)12-19/h2-8,13-14,19-20,22,25H,9-12,15H2,1H3,(H,33,36)/t20-,22+,25+/m1/s1 FNAUREXCQYLQJG-KJWPAHLWSA-N 635087 US11814367, Compound 536 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635087&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349829 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cnc2ccccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(cn1)C1CC(F)(F)C1 InChI=1S/C30H28F3N5O2/c31-22-12-26(38(16-22)27(39)17-37-18-35-23-8-4-5-9-25(23)37)29(40)36-28(19-6-2-1-3-7-19)24-11-10-20(15-34-24)21-13-30(32,33)14-21/h1-11,15,18,21-22,26,28H,12-14,16-17H2,(H,36,40)/t22-,26+,28+/m1/s1 WSZWZVMHZAPIOP-ZEZZXZOMSA-N 635088 US11814367, Compound 537 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635088&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349830 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CC(F)(F)C1)C(=O)N[C@@H](c1ccccc1)c1ccc(cn1)C1CC(F)(F)C1 InChI=1S/C27H28F5N5O3/c28-19-8-21(37(13-19)22(38)12-34-25(40)36-14-27(31,32)15-36)24(39)35-23(16-4-2-1-3-5-16)20-7-6-17(11-33-20)18-9-26(29,30)10-18/h1-7,11,18-19,21,23H,8-10,12-15H2,(H,34,40)(H,35,39)/t19-,21+,23+/m1/s1 XAHIEWHTCCIJNL-NWSQWKLXSA-N 635089 US11814367, Compound 538 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635089&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349831 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ncco1)C(=O)N[C@@H](c1ccccc1)c1ccc(cn1)C1CC(F)(F)C1 InChI=1S/C26H25F3N4O3/c27-19-10-21(33(15-19)23(34)11-22-30-8-9-36-22)25(35)32-24(16-4-2-1-3-5-16)20-7-6-17(14-31-20)18-12-26(28,29)13-18/h1-9,14,18-19,21,24H,10-13,15H2,(H,32,35)/t19-,21+,24+/m1/s1 COTTVTPLUIOTFC-IZIIKQMZSA-N 635090 US11814367, Compound 539 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635090&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349832 Cc1coc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cn2)C2CC(F)(F)C2)n1 InChI=1S/C27H27F3N4O3/c1-16-15-37-23(32-16)10-24(35)34-14-20(28)9-22(34)26(36)33-25(17-5-3-2-4-6-17)21-8-7-18(13-31-21)19-11-27(29,30)12-19/h2-8,13,15,19-20,22,25H,9-12,14H2,1H3,(H,33,36)/t20-,22+,25+/m1/s1 GPWJKJZDUOADCZ-KJWPAHLWSA-N 635091 US11814367, Compound 540 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635091&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349833 Cc1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cn2)C2CC(F)(F)C2)c(=O)o1 InChI=1S/C26H26F3N5O4/c1-15-32-34(25(37)38-15)14-22(35)33-13-19(27)9-21(33)24(36)31-23(16-5-3-2-4-6-16)20-8-7-17(12-30-20)18-10-26(28,29)11-18/h2-8,12,18-19,21,23H,9-11,13-14H2,1H3,(H,31,36)/t19-,21+,23+/m1/s1 VPKUQDMMYSGXEF-NWSQWKLXSA-N 635092 US11814367, Compound 541 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635092&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349834 F[C@@H]1C[C@H](N(C1)C(=O)Cc1[nH]nnc1C(F)(F)F)C(=O)N[C@@H](c1ccccc1)c1ccc(cn1)C1CC(F)(F)C1 635093 US11814367, Compound 542 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635093&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349835 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CCC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)c1 InChI=1S/C28H30F4N4O3/c29-20-12-23(36(16-20)24(37)15-33-27(39)35-9-4-10-35)26(38)34-25(17-5-2-1-3-6-17)18-7-8-21(22(30)11-18)19-13-28(31,32)14-19/h1-3,5-8,11,19-20,23,25H,4,9-10,12-16H2,(H,33,39)(H,34,38)/t20-,23+,25+/m1/s1 VTUMKSGWVQLHBU-PBXXJUDPSA-N 635095 US11814367, Compound 544 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635095&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349836 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cnn[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)c1 635097 US11814367, Compound 546 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635097&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349837 CN(C)C(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)c1 InChI=1S/C27H30F4N4O3/c1-34(2)26(38)32-14-23(36)35-15-19(28)11-22(35)25(37)33-24(16-6-4-3-5-7-16)17-8-9-20(21(29)10-17)18-12-27(30,31)13-18/h3-10,18-19,22,24H,11-15H2,1-2H3,(H,32,38)(H,33,37)/t19-,22+,24+/m1/s1 PVTKZJUAOADKOT-UCFCWBNQSA-N 635098 US11814367, Compound 547 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635098&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349838 CN(C)C(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)c1 InChI=1S/C27H30F4N4O3/c1-34(2)26(38)32-14-23(36)35-15-19(28)11-22(35)25(37)33-24(16-6-4-3-5-7-16)17-8-9-20(21(29)10-17)18-12-27(30,31)13-18/h3-10,18-19,22,24H,11-15H2,1-2H3,(H,32,38)(H,33,37)/t19-,22+,24-/m1/s1 PVTKZJUAOADKOT-WNOPAQSVSA-N 635099 US11814367, Compound 548 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635099&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349839 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cnc2ccccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)c1 InChI=1S/C31H28F4N4O2/c32-22-13-27(39(16-22)28(40)17-38-18-36-25-8-4-5-9-26(25)38)30(41)37-29(19-6-2-1-3-7-19)20-10-11-23(24(33)12-20)21-14-31(34,35)15-21/h1-12,18,21-22,27,29H,13-17H2,(H,37,41)/t22-,27+,29+/m1/s1 DHKNOSMXNAPPFH-RVBRUHEGSA-N 635100 US11814367, Compound 549 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635100&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349840 Cc1cnc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)c2)o1 InChI=1S/C28H27F4N3O3/c1-16-14-33-24(38-16)11-25(36)35-15-20(29)10-23(35)27(37)34-26(17-5-3-2-4-6-17)18-7-8-21(22(30)9-18)19-12-28(31,32)13-19/h2-9,14,19-20,23,26H,10-13,15H2,1H3,(H,34,37)/t20-,23+,26+/m1/s1 BSEWUFPOJWYQNP-SEIBCYHCSA-N 635101 US11814367, Compound 550 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635101&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349841 Cc1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)c2)c(=O)[nH]c1=O 635102 US11814367, Compound 551 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635102&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349842 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ncco1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)c1 InChI=1S/C27H25F4N3O3/c28-19-11-22(34(15-19)24(35)12-23-32-8-9-37-23)26(36)33-25(16-4-2-1-3-5-16)17-6-7-20(21(29)10-17)18-13-27(30,31)14-18/h1-10,18-19,22,25H,11-15H2,(H,33,36)/t19-,22+,25+/m1/s1 FNEBFZFJDMBBBN-WPWBMXPQSA-N 635103 US11814367, Compound 552 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635103&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349843 F[C@@H]1C[C@H](N(C1)C(=O)Cc1[nH]nnc1C(F)(F)F)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC(F)(F)C2)c(F)c1 635104 US11814367, Compound 553 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635104&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349844 Cc1coc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC(F)(F)C3)c(F)c2)n1 InChI=1S/C28H27F4N3O3/c1-16-15-38-24(33-16)11-25(36)35-14-20(29)10-23(35)27(37)34-26(17-5-3-2-4-6-17)18-7-8-21(22(30)9-18)19-12-28(31,32)13-19/h2-9,15,19-20,23,26H,10-14H2,1H3,(H,34,37)/t20-,23+,26+/m1/s1 XEXBUDCGZJLHIQ-SEIBCYHCSA-N 635105 US11814367, Compound 554 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635105&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349845 Cc1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)c2)C2(C)CC2)c(=O)[nH]c1=O 635107 US11814367, Compound 556 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635107&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349846 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635109 US11814367, Compound 558 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635109&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349847 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)COC(=O)N1CCC1)c1ccccc1 InChI=1S/C28H31F2N3O4/c1-28(10-11-28)21-9-8-19(14-22(21)30)25(18-6-3-2-4-7-18)31-26(35)23-15-20(29)16-33(23)24(34)17-37-27(36)32-12-5-13-32/h2-4,6-9,14,20,23,25H,5,10-13,15-17H2,1H3,(H,31,35)/t20-,23+,25+/m1/s1 QKTUCWSRFBPXFG-PBXXJUDPSA-N 635111 US11814367, Compound 560 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635111&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349848 Cn1c(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)c2)C2(C)CC2)cc2ccccc12 InChI=1S/C33H33F2N3O2/c1-33(14-15-33)26-13-12-23(17-27(26)35)31(21-8-4-3-5-9-21)36-32(40)29-18-24(34)20-38(29)30(39)19-25-16-22-10-6-7-11-28(22)37(25)2/h3-13,16-17,24,29,31H,14-15,18-20H2,1-2H3,(H,36,40)/t24-,29+,31+/m1/s1 NXPGLEIHCSMAQK-AVKNQKEWSA-N 635112 US11814367, Compound 561 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635112&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349849 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CCNCC1=O)c1ccccc1 InChI=1S/C28H32F2N4O3/c1-28(9-10-28)21-8-7-19(13-22(21)30)26(18-5-3-2-4-6-18)32-27(37)23-14-20(29)16-34(23)25(36)17-33-12-11-31-15-24(33)35/h2-8,13,20,23,26,31H,9-12,14-17H2,1H3,(H,32,37)/t20-,23+,26+/m1/s1 MUZZLAMSCFMIEC-SEIBCYHCSA-N 635113 US11814367, Compound 562 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635113&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349850 Cn1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)c2)C2(C)CC2)c2ccccc12 InChI=1S/C33H33F2N3O2/c1-33(14-15-33)26-13-12-22(16-27(26)35)31(21-8-4-3-5-9-21)36-32(40)29-18-24(34)20-38(29)30(39)17-23-19-37(2)28-11-7-6-10-25(23)28/h3-13,16,19,24,29,31H,14-15,17-18,20H2,1-2H3,(H,36,40)/t24-,29+,31+/m1/s1 OGTQMFCCXGGZHL-AVKNQKEWSA-N 635114 US11814367, Compound 563 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635114&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349851 Cn1nc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)c2)C2(C)CC2)c2ccccc12 InChI=1S/C32H32F2N4O2/c1-32(14-15-32)24-13-12-21(16-25(24)34)30(20-8-4-3-5-9-20)35-31(40)28-17-22(33)19-38(28)29(39)18-26-23-10-6-7-11-27(23)37(2)36-26/h3-13,16,22,28,30H,14-15,17-19H2,1-2H3,(H,35,40)/t22-,28+,30+/m1/s1 WJWLUPKBKOENFB-JPDBUEETSA-N 635115 US11814367, Compound 564 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635115&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349852 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CCOCC1)c1ccccc1 InChI=1S/C29H34F2N4O4/c1-29(9-10-29)22-8-7-20(15-23(22)31)26(19-5-3-2-4-6-19)33-27(37)24-16-21(30)18-35(24)25(36)17-32-28(38)34-11-13-39-14-12-34/h2-8,15,21,24,26H,9-14,16-18H2,1H3,(H,32,38)(H,33,37)/t21-,24+,26+/m1/s1 DMRWDWDGHMIMBU-DSBYRVASSA-N 635116 US11814367, Compound 565 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635116&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349853 Cc1nc2ccccc2n1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(c(F)c1)C1(C)CC1 InChI=1S/C32H32F2N4O2/c1-20-35-26-10-6-7-11-27(26)37(20)19-29(39)38-18-23(33)17-28(38)31(40)36-30(21-8-4-3-5-9-21)22-12-13-24(25(34)16-22)32(2)14-15-32/h3-13,16,23,28,30H,14-15,17-19H2,1-2H3,(H,36,40)/t23-,28+,30+/m1/s1 WSLHLSWXBWVOSN-SLTKKEMYSA-N 635117 US11814367, Compound 566 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635117&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349854 CC(C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(c(F)c1)C1(C)CC1)n1cnc2ccccc12 InChI=1S/C32H32F2N4O2/c1-20(38-19-35-26-10-6-7-11-27(26)38)31(40)37-18-23(33)17-28(37)30(39)36-29(21-8-4-3-5-9-21)22-12-13-24(25(34)16-22)32(2)14-15-32/h3-13,16,19-20,23,28-29H,14-15,17-18H2,1-2H3,(H,36,39)/t20?,23-,28+,29+/m1/s1 HAXZRNRUYMBWFB-XVTCUHATSA-N 635118 US11814367, Compound 567::US11814367, Compound 574 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635118&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349855 Cn1c2ccccc2n(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)c2)C2(C)CC2)c1=O InChI=1S/C32H32F2N4O3/c1-32(14-15-32)23-13-12-21(16-24(23)34)29(20-8-4-3-5-9-20)35-30(40)27-17-22(33)18-37(27)28(39)19-38-26-11-7-6-10-25(26)36(2)31(38)41/h3-13,16,22,27,29H,14-15,17-19H2,1-2H3,(H,35,40)/t22-,27+,29+/m1/s1 KLJULYDJWVNEFC-RVBRUHEGSA-N 635119 US11814367, Compound 568::US11814367, Compound 577 Glycogen [starch] synthase, liver 94240 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635119&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349856 Cn1c(=O)ccn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)c2)C2(C)CC2)c1=O InChI=1S/C29H30F2N4O4/c1-29(11-12-29)21-9-8-19(14-22(21)31)26(18-6-4-3-5-7-18)32-27(38)23-15-20(30)16-35(23)25(37)17-34-13-10-24(36)33(2)28(34)39/h3-10,13-14,20,23,26H,11-12,15-17H2,1-2H3,(H,32,38)/t20-,23+,26+/m1/s1 NMQAMZCAIZNLPX-SEIBCYHCSA-N 635120 US11814367, Compound 569 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635120&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349857 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1c2ccccc2[nH]c1=O)c1ccccc1 635121 US11814367, Compound 570 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635121&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349858 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1n[nH]c2ccccc12)c1ccccc1 635122 US11814367, Compound 571 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635122&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349859 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CC(=O)NCC1=O)c1ccccc1 InChI=1S/C28H30F2N4O4/c1-28(9-10-28)20-8-7-18(11-21(20)30)26(17-5-3-2-4-6-17)32-27(38)22-12-19(29)14-34(22)25(37)16-33-15-23(35)31-13-24(33)36/h2-8,11,19,22,26H,9-10,12-16H2,1H3,(H,31,35)(H,32,38)/t19-,22+,26+/m1/s1 YKRVFSILFRQSPH-GSPPDTAYSA-N 635123 US11814367, Compound 572 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635123&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349860 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1Cc2ccccc2C1=O)c1ccccc1 InChI=1S/C32H31F2N3O3/c1-32(13-14-32)25-12-11-21(15-26(25)34)29(20-7-3-2-4-8-20)35-30(39)27-16-23(33)18-37(27)28(38)19-36-17-22-9-5-6-10-24(22)31(36)40/h2-12,15,23,27,29H,13-14,16-19H2,1H3,(H,35,39)/t23-,27+,29+/m1/s1 AUFBLONFTKEBLT-OVTKCHPXSA-N 635124 US11814367, Compound 573 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635124&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349861 CC(C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(c(F)c1)C1(C)CC1)n1cnc2ccccc12 InChI=1S/C32H32F2N4O2/c1-20(38-19-35-26-10-6-7-11-27(26)38)31(40)37-18-23(33)17-28(37)30(39)36-29(21-8-4-3-5-9-21)22-12-13-24(25(34)16-22)32(2)14-15-32/h3-13,16,19-20,23,28-29H,14-15,17-18H2,1-2H3,(H,36,39)/t20?,23-,28+,29+/m1/s1 HAXZRNRUYMBWFB-XVTCUHATSA-N 635118 US11814367, Compound 567::US11814367, Compound 574 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635118&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349862 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nnc2ccccc12)c1ccccc1 InChI=1S/C30H29F2N5O2/c1-30(13-14-30)22-12-11-20(15-23(22)32)28(19-7-3-2-4-8-19)33-29(39)26-16-21(31)17-36(26)27(38)18-37-25-10-6-5-9-24(25)34-35-37/h2-12,15,21,26,28H,13-14,16-18H2,1H3,(H,33,39)/t21-,26+,28+/m1/s1 PZOSFBHTUMAIML-LARUCZGFSA-N 635126 US11814367, Compound 575 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635126&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349863 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1C(=O)Cc2ccccc12)c1ccccc1 InChI=1S/C32H31F2N3O3/c1-32(13-14-32)24-12-11-22(15-25(24)34)30(20-7-3-2-4-8-20)35-31(40)27-17-23(33)18-36(27)29(39)19-37-26-10-6-5-9-21(26)16-28(37)38/h2-12,15,23,27,30H,13-14,16-19H2,1H3,(H,35,40)/t23-,27+,30+/m1/s1 ZQPTYLKLULNODK-MGTSJQRLSA-N 635127 US11814367, Compound 576 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635127&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349864 Cn1c2ccccc2n(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)c2)C2(C)CC2)c1=O InChI=1S/C32H32F2N4O3/c1-32(14-15-32)23-13-12-21(16-24(23)34)29(20-8-4-3-5-9-20)35-30(40)27-17-22(33)18-37(27)28(39)19-38-26-11-7-6-10-25(26)36(2)31(38)41/h3-13,16,22,27,29H,14-15,17-19H2,1-2H3,(H,35,40)/t22-,27+,29+/m1/s1 KLJULYDJWVNEFC-RVBRUHEGSA-N 635119 US11814367, Compound 568::US11814367, Compound 577 Glycogen [starch] synthase, liver 41180 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635119&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349865 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CCN(CC1=O)C(=O)OCC(F)(F)F)c1ccccc1 InChI=1S/C31H33F5N4O5/c1-30(9-10-30)22-8-7-20(13-23(22)33)27(19-5-3-2-4-6-19)37-28(43)24-14-21(32)15-40(24)26(42)17-38-11-12-39(16-25(38)41)29(44)45-18-31(34,35)36/h2-8,13,21,24,27H,9-12,14-18H2,1H3,(H,37,43)/t21-,24+,27+/m1/s1 ZYIDOACTOWJPHA-QURRFSBHSA-N 635129 US11814367, Compound 578 Glycogen [starch] synthase, liver 79270 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635129&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349866 COCCN1CCN(CC1)C(=O)OCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(c(F)c1)C1(C)CC1 InChI=1S/C32H40F2N4O5/c1-32(10-11-32)25-9-8-23(18-26(25)34)29(22-6-4-3-5-7-22)35-30(40)27-19-24(33)20-38(27)28(39)21-43-31(41)37-14-12-36(13-15-37)16-17-42-2/h3-9,18,24,27,29H,10-17,19-21H2,1-2H3,(H,35,40)/t24-,27+,29+/m1/s1 SWIHAXCCWRCFAE-QXGAZULMSA-N 635130 US11814367, Compound 579 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635130&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349867 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CCN(CC(F)(F)F)CC1=O)c1ccccc1 InChI=1S/C30H33F5N4O3/c1-29(9-10-29)22-8-7-20(13-23(22)32)27(19-5-3-2-4-6-19)36-28(42)24-14-21(31)15-39(24)26(41)17-38-12-11-37(16-25(38)40)18-30(33,34)35/h2-8,13,21,24,27H,9-12,14-18H2,1H3,(H,36,42)/t21-,24+,27+/m1/s1 CINBWLBTNFSOML-QURRFSBHSA-N 635131 US11814367, Compound 580 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635131&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349868 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CC1C(=O)Nc2ccccc12)c1ccccc1 InChI=1S/C32H31F2N3O3/c1-32(13-14-32)24-12-11-20(15-25(24)34)29(19-7-3-2-4-8-19)36-31(40)27-16-21(33)18-37(27)28(38)17-23-22-9-5-6-10-26(22)35-30(23)39/h2-12,15,21,23,27,29H,13-14,16-18H2,1H3,(H,35,39)(H,36,40)/t21-,23?,27+,29+/m1/s1 ALQZJJRFCOSTNK-ZHVXBTQQSA-N 635132 US11814367, Compound 581 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635132&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349869 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnnc1)c1ccccc1 InChI=1S/C26H27F2N5O2/c1-26(9-10-26)20-8-7-18(11-21(20)28)24(17-5-3-2-4-6-17)31-25(35)22-12-19(27)13-33(22)23(34)14-32-15-29-30-16-32/h2-8,11,15-16,19,22,24H,9-10,12-14H2,1H3,(H,31,35)/t19-,22+,24+/m1/s1 TWUCERZJXCDDDA-UCFCWBNQSA-N 635133 US11814367, Compound 582 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635133&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349870 CN1CCN(CC1)C(=O)OCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(c(F)c1)C1(C)CC1 InChI=1S/C30H36F2N4O4/c1-30(10-11-30)23-9-8-21(16-24(23)32)27(20-6-4-3-5-7-20)33-28(38)25-17-22(31)18-36(25)26(37)19-40-29(39)35-14-12-34(2)13-15-35/h3-9,16,22,25,27H,10-15,17-19H2,1-2H3,(H,33,38)/t22-,25+,27+/m1/s1 JZVZTJMMSNBQND-PWMMPXSUSA-N 635134 US11814367, Compound 583 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635134&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349871 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)COC(=O)N1CCN(CC2CC2)CC1)c1ccccc1 InChI=1S/C33H40F2N4O4/c1-33(11-12-33)26-10-9-24(17-27(26)35)30(23-5-3-2-4-6-23)36-31(41)28-18-25(34)20-39(28)29(40)21-43-32(42)38-15-13-37(14-16-38)19-22-7-8-22/h2-6,9-10,17,22,25,28,30H,7-8,11-16,18-21H2,1H3,(H,36,41)/t25-,28+,30+/m1/s1 JHLULJZDHJXHPP-YRGIIOSFSA-N 635135 US11814367, Compound 584 Glycogen [starch] synthase, liver >91760 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635135&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349872 CC1(CC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)COC(=O)N1CCN(CC(F)(F)F)CC1)c1ccccc1 InChI=1S/C31H35F5N4O4/c1-30(9-10-30)23-8-7-21(15-24(23)33)27(20-5-3-2-4-6-20)37-28(42)25-16-22(32)17-40(25)26(41)18-44-29(43)39-13-11-38(12-14-39)19-31(34,35)36/h2-8,15,22,25,27H,9-14,16-19H2,1H3,(H,37,42)/t22-,25+,27+/m1/s1 QXWLZQRPGIISOV-PWMMPXSUSA-N 635136 US11814367, Compound 585 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635136&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349873 CC(C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(c(F)n1)C1(C)CC1)n1cnc2ccccc12 InChI=1S/C31H31F2N5O2/c1-19(38-18-34-23-10-6-7-11-25(23)38)30(40)37-17-21(32)16-26(37)29(39)36-27(20-8-4-3-5-9-20)24-13-12-22(28(33)35-24)31(2)14-15-31/h3-13,18-19,21,26-27H,14-17H2,1-2H3,(H,36,39)/t19?,21-,26+,27+/m1/s1 YJUXQZZDNMZHSE-WWKOXFJPSA-N 635137 US11814367, Compound 586::US11814367, Compound 587 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635137&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349874 CC(C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(c(F)n1)C1(C)CC1)n1cnc2ccccc12 InChI=1S/C31H31F2N5O2/c1-19(38-18-34-23-10-6-7-11-25(23)38)30(40)37-17-21(32)16-26(37)29(39)36-27(20-8-4-3-5-9-20)24-13-12-22(28(33)35-24)31(2)14-15-31/h3-13,18-19,21,26-27H,14-17H2,1-2H3,(H,36,39)/t19?,21-,26+,27+/m1/s1 YJUXQZZDNMZHSE-WWKOXFJPSA-N 635137 US11814367, Compound 586::US11814367, Compound 587 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635137&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349875 CC1(CC1)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1n[nH]c2ccccc12)c1ccccc1 635139 US11814367, Compound 588 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635139 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635139&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349876 CC1(CC1)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CCOCC1)c1ccccc1 InChI=1S/C28H33F2N5O4/c1-28(9-10-28)20-7-8-21(32-25(20)30)24(18-5-3-2-4-6-18)33-26(37)22-15-19(29)17-35(22)23(36)16-31-27(38)34-11-13-39-14-12-34/h2-8,19,22,24H,9-17H2,1H3,(H,31,38)(H,33,37)/t19-,22+,24+/m1/s1 FGNXIZBMVWLJSF-UCFCWBNQSA-N 635140 US11814367, Compound 589 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635140&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349877 CC1(CC1)c1ccc(nc1F)[C@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1n[nH]c2ccccc12)c1ccccc1 635141 US11814367, Compound 590 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635141&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349878 Cn1c(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)n2)C2(C)CC2)cc2ccccc12 InChI=1S/C32H32F2N4O2/c1-32(14-15-32)24-12-13-25(35-30(24)34)29(20-8-4-3-5-9-20)36-31(40)27-17-22(33)19-38(27)28(39)18-23-16-21-10-6-7-11-26(21)37(23)2/h3-13,16,22,27,29H,14-15,17-19H2,1-2H3,(H,36,40)/t22-,27+,29+/m1/s1 CDFNKKRSKBIQRN-RVBRUHEGSA-N 635142 US11814367, Compound 591 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635142&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349879 Cn1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)n2)C2(C)CC2)c2ccccc12 InChI=1S/C32H32F2N4O2/c1-32(14-15-32)24-12-13-25(35-30(24)34)29(20-8-4-3-5-9-20)36-31(40)27-17-22(33)19-38(27)28(39)16-21-18-37(2)26-11-7-6-10-23(21)26/h3-13,18,22,27,29H,14-17,19H2,1-2H3,(H,36,40)/t22-,27+,29+/m1/s1 VDKWLSWZQQRTAX-RVBRUHEGSA-N 635143 US11814367, Compound 592 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635143 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635143&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349880 Cc1nc2ccccc2n1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(c(F)n1)C1(C)CC1 InChI=1S/C31H31F2N5O2/c1-19-34-23-10-6-7-11-25(23)37(19)18-27(39)38-17-21(32)16-26(38)30(40)36-28(20-8-4-3-5-9-20)24-13-12-22(29(33)35-24)31(2)14-15-31/h3-13,21,26,28H,14-18H2,1-2H3,(H,36,40)/t21-,26+,28+/m1/s1 YKWGERSFOZZMBK-LARUCZGFSA-N 635144 US11814367, Compound 593 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635144&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349881 CC1(CC1)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nnc2ccccc12)c1ccccc1 InChI=1S/C29H28F2N6O2/c1-29(13-14-29)20-11-12-22(32-27(20)31)26(18-7-3-2-4-8-18)33-28(39)24-15-19(30)16-36(24)25(38)17-37-23-10-6-5-9-21(23)34-35-37/h2-12,19,24,26H,13-17H2,1H3,(H,33,39)/t19-,24+,26+/m1/s1 UFZZELSWIBVWBZ-LUPFDQBXSA-N 635145 US11814367, Compound 594 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635145&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349882 CC1(CC1)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnc2ccccc12)c1ccccc1 InChI=1S/C30H29F2N5O2/c1-30(13-14-30)21-11-12-23(34-28(21)32)27(19-7-3-2-4-8-19)35-29(39)25-15-20(31)16-37(25)26(38)17-36-18-33-22-9-5-6-10-24(22)36/h2-12,18,20,25,27H,13-17H2,1H3,(H,35,39)/t20-,25+,27+/m1/s1 DOVOQWBIUKIKCN-RAHIQWLESA-N 635146 US11814367, Compound 595 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635146&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349883 Cn1nc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)n2)C2(C)CC2)c2ccccc12 InChI=1S/C31H31F2N5O2/c1-31(14-15-31)22-12-13-23(34-29(22)33)28(19-8-4-3-5-9-19)35-30(40)26-16-20(32)18-38(26)27(39)17-24-21-10-6-7-11-25(21)37(2)36-24/h3-13,20,26,28H,14-18H2,1-2H3,(H,35,40)/t20-,26+,28+/m1/s1 QKBABOAMYISMPW-PBZMZIQDSA-N 635147 US11814367, Compound 596 Glycogen [starch] synthase, liver >96680 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635147&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349884 CN1C(=O)C(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)n2)C2(C)CC2)c2ccccc12 InChI=1S/C32H32F2N4O3/c1-32(14-15-32)23-12-13-24(35-29(23)34)28(19-8-4-3-5-9-19)36-30(40)26-16-20(33)18-38(26)27(39)17-22-21-10-6-7-11-25(21)37(2)31(22)41/h3-13,20,22,26,28H,14-18H2,1-2H3,(H,36,40)/t20-,22?,26+,28+/m1/s1 IGPZPGHRKGLHND-ZWDGKEEKSA-N 635148 US11814367, Compound 597 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635148&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349885 CC1(CC1)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1c2ccccc2[nH]c1=O)c1ccccc1 635150 US11814367, Compound 599 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635150&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349886 Cn1c2ccccc2n(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(c(F)n2)C2(C)CC2)c1=O InChI=1S/C31H31F2N5O3/c1-31(14-15-31)21-12-13-22(34-28(21)33)27(19-8-4-3-5-9-19)35-29(40)25-16-20(32)17-37(25)26(39)18-38-24-11-7-6-10-23(24)36(2)30(38)41/h3-13,20,25,27H,14-18H2,1-2H3,(H,35,40)/t20-,25+,27+/m1/s1 JMWVGDFYEZFTCY-RAHIQWLESA-N 635151 US11814367, Compound 600 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635151&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349887 CC(C)c1cnc(cc1C)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(o1)C(F)F)c1ccccc1 InChI=1S/C26H28F3N5O3/c1-14(2)18-12-30-19(9-15(18)3)23(16-7-5-4-6-8-16)31-25(36)20-10-17(27)13-34(20)22(35)11-21-32-33-26(37-21)24(28)29/h4-9,12,14,17,20,23-24H,10-11,13H2,1-3H3,(H,31,36)/t17-,20+,23+/m1/s1 VJFLVNWWMIGBGQ-MONBJTKQSA-N 635153 US11814367, Compound 602 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635153 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635153&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349888 CC(=O)N1C[C@H](F)C[C@H]1C(=O)NC(c1ccccc1)c1ccc(cn1)C1CCC1 InChI=1S/C23H26FN3O2/c1-15(28)27-14-19(24)12-21(27)23(29)26-22(17-6-3-2-4-7-17)20-11-10-18(13-25-20)16-8-5-9-16/h2-4,6-7,10-11,13,16,19,21-22H,5,8-9,12,14H2,1H3,(H,26,29)/t19-,21+,22?/m1/s1 VWHNWUBBMWGINU-DOYJUQJDSA-N 635154 US11814367, Compound 603 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635154&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349889 CC(C)c1cnc(cc1C)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635155 US11814367, Compound 604 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635155&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349890 CC(C)c1cnc(cc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635156 US11814367, Compound 605 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635156&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349891 CC(C)c1ccc(nc1C)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635158 US11814367, Compound 607 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635158&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349892 CC(C)c1ccc(nc1C)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(o1)C(F)F)c1ccccc1 InChI=1S/C26H28F3N5O3/c1-14(2)18-9-10-19(30-15(18)3)23(16-7-5-4-6-8-16)31-25(36)20-11-17(27)13-34(20)22(35)12-21-32-33-26(37-21)24(28)29/h4-10,14,17,20,23-24H,11-13H2,1-3H3,(H,31,36)/t17-,20+,23?/m1/s1 DTKNJCGRGXBJPB-LRNSAUPQSA-N 635160 US11814367, Compound 609 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635160&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349893 CC(C)(C)c1ccc(nc1)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635162 US11814367, Compound 611 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635162&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349894 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1cccnc1N 635164 US11814367, Compound 613 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635164&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349895 CC(C)c1ccc(cc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccc(N)nc1 635171 US11814367, Compound 620 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635171&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349896 CC(C)c1ccc(cc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccn[nH]1 635174 US11814367, Compound 623 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635174&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349897 CC(C)c1ccc(cc1C)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c(C)nn(C)c1C)c1cccnc1N InChI=1S/C29H37FN6O2/c1-16(2)22-10-9-20(12-17(22)3)27(23-8-7-11-32-28(23)31)33-29(38)25-13-21(30)15-36(25)26(37)14-24-18(4)34-35(6)19(24)5/h7-12,16,21,25,27H,13-15H2,1-6H3,(H2,31,32)(H,33,38)/t21-,25+,27?/m1/s1 MIVYKPMFLCZCTR-ROEJTFNWSA-N 635176 US11814367, Compound 625 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635176&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349898 CC(C)c1ccc(nc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ncco1)c1ccn[nH]1 635181 US11814367, Compound 630 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635181&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349899 CC(C)c1ccc(nc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccn2cncc2c1 635182 US11814367, Compound 631 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635182&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349900 CC(C)c1ccc(nc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccc2cn[nH]c2c1 635183 US11814367, Compound 632::US11814367, Compound 633 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635183&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349901 COc1ccccc1[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)c1ccc(cc1)C(C)C InChI=1S/C24H30N2O3/c1-16(2)18-11-13-19(14-12-18)23(20-8-5-6-10-22(20)29-4)25-24(28)21-9-7-15-26(21)17(3)27/h5-6,8,10-14,16,21,23H,7,9,15H2,1-4H3,(H,25,28)/t21-,23+/m0/s1 AVIUCDAEOCEXGX-JTHBVZDNSA-N 635190 US11814367, Compound 639::US11814367, Compound 640 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635190&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349902 COc1ccccc1[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)c1ccc(cc1)C(C)C InChI=1S/C24H30N2O3/c1-16(2)18-11-13-19(14-12-18)23(20-8-5-6-10-22(20)29-4)25-24(28)21-9-7-15-26(21)17(3)27/h5-6,8,10-14,16,21,23H,7,9,15H2,1-4H3,(H,25,28)/t21-,23+/m0/s1 AVIUCDAEOCEXGX-JTHBVZDNSA-N 635190 US11814367, Compound 639::US11814367, Compound 640 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635190&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349903 CC(C)c1ccc(cc1)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(C)=O)c1ccccc1N InChI=1S/C23H28FN3O2/c1-14(2)16-8-10-17(11-9-16)22(19-6-4-5-7-20(19)25)26-23(29)21-12-18(24)13-27(21)15(3)28/h4-11,14,18,21-22H,12-13,25H2,1-3H3,(H,26,29)/t18-,21+,22?/m1/s1 ZOSDSCOUPPJINV-LJDIEGPPSA-N 635193 US11814367, Compound 642 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635193&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349904 CC(C)c1ccc(cc1)C(NC(=O)[C@@H]1CCCN1C(=O)Cc1cnn[nH]1)c1cccc2[nH]c(=O)[nH]c12 635195 US11814367, Compound 644 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635195&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349905 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1cccc(F)c1 635196 US11814367, Compound 645 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635196&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349906 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccc(F)cc1 635197 US11814367, Compound 646 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635197&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349907 COc1cccc(c1)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccc(C(C)C)c(F)n1 635202 US11814367, Compound 651 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635202&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349908 CC(C)c1ccc(nc1F)C(CC1CC1)NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1 635204 US11814367, Compound 653 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635204&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349909 CC(C)c1c(F)cc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1S(=O)(=O)Cc1cnn[nH]1)c1ccccc1 635210 US11814367, Compound 659 Glycogen [starch] synthase, liver 17530 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635210&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349910 CC(=O)N1C[C@H](F)C[C@H]1C(=O)NC(c1ccccc1)c1ccc(C2CCC2)c(F)c1 InChI=1S/C24H26F2N2O2/c1-15(29)28-14-19(25)13-22(28)24(30)27-23(17-6-3-2-4-7-17)18-10-11-20(21(26)12-18)16-8-5-9-16/h2-4,6-7,10-12,16,19,22-23H,5,8-9,13-14H2,1H3,(H,27,30)/t19-,22+,23?/m1/s1 ZFFTXTDKSDFUOX-BSJAROSPSA-N 635211 US11814367, Compound 660 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635211&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349911 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ncco1)C(=O)NC(c1ccccc1)c1cc(F)c(C2CC2)c(F)c1 InChI=1S/C26H24F3N3O3/c27-18-12-21(32(14-18)23(33)13-22-30-8-9-35-22)26(34)31-25(16-4-2-1-3-5-16)17-10-19(28)24(15-6-7-15)20(29)11-17/h1-5,8-11,15,18,21,25H,6-7,12-14H2,(H,31,34)/t18-,21+,25?/m1/s1 PQWJSRTUUWVULS-XQVBRHIYSA-N 635212 US11814367, Compound 661::US11814367, Compound 662 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635212&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349912 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ncco1)C(=O)NC(c1ccccc1)c1cc(F)c(C2CC2)c(F)c1 InChI=1S/C26H24F3N3O3/c27-18-12-21(32(14-18)23(33)13-22-30-8-9-35-22)26(34)31-25(16-4-2-1-3-5-16)17-10-19(28)24(15-6-7-15)20(29)11-17/h1-5,8-11,15,18,21,25H,6-7,12-14H2,(H,31,34)/t18-,21+,25?/m1/s1 PQWJSRTUUWVULS-XQVBRHIYSA-N 635212 US11814367, Compound 661::US11814367, Compound 662 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635212&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349913 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cnn[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(Cl)c1 635215 US11814367, Compound 664 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635215&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349914 Cc1cc(ccc1C1CC1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635216 US11814367, Compound 665 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635216&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349915 CC(C)c1c(F)cc(cc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635217 US11814367, Compound 666::US11814367, Compound 667 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635217&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349916 CC(C)c1c(F)cc(cc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccnn1)c1ccccc1 InChI=1S/C25H26F3N5O2/c1-15(2)23-19(27)10-17(11-20(23)28)24(16-6-4-3-5-7-16)30-25(35)21-12-18(26)13-33(21)22(34)14-32-9-8-29-31-32/h3-11,15,18,21,24H,12-14H2,1-2H3,(H,30,35)/t18-,21+,24?/m1/s1 YGFROUPHCPRWFQ-BGNYOVEWSA-N 635219 US11814367, Compound 668 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635219&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349917 CC(C)c1c(F)cc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnnn1)c1ccccc1 InChI=1S/C24H25F3N6O2/c1-14(2)22-18(26)8-16(9-19(22)27)23(15-6-4-3-5-7-15)29-24(35)20-10-17(25)11-33(20)21(34)12-32-13-28-30-31-32/h3-9,13-14,17,20,23H,10-12H2,1-2H3,(H,29,35)/t17-,20+,23+/m1/s1 HAZFGFJTQNOGPK-MONBJTKQSA-N 635220 US11814367, Compound 669 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635220&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349918 CC(C)c1ccc(cc1C)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635221 US11814367, Compound 670 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635221&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349919 CC(C)c1ccc(cc1Cl)[C@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635222 US11814367, Compound 671 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635222&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349920 CC(C)c1ccc(cc1Cl)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635223 US11814367, Compound 672 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635223&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349921 F[C@@H]1C[C@H](N(C1)C(=O)Cc1cnn[nH]1)C(=O)NC(c1ccccc1)c1ccc(C2CCC2)c(F)c1 635224 US11814367, Compound 673::US11814367, Compound 674 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635224&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349922 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cnnn1)C(=O)NC(c1ccccc1)c1ccc(C2CCC2)c(F)c1 InChI=1S/C25H26F2N6O2/c26-19-12-22(33(13-19)23(34)14-32-15-28-30-31-32)25(35)29-24(17-5-2-1-3-6-17)18-9-10-20(21(27)11-18)16-7-4-8-16/h1-3,5-6,9-11,15-16,19,22,24H,4,7-8,12-14H2,(H,29,35)/t19-,22+,24?/m1/s1 UHJNQMNSCAPQMU-LOMQJKJHSA-N 635226 US11814367, Compound 675 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635226&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349923 CCC(C)c1ccc(cc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635227 US11814367, Compound 676::US11814367, Compound 677 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635227&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349924 CCC(C)c1ccc(cc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635227 US11814367, Compound 676::US11814367, Compound 677 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635227&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349925 CC(C)c1ccc(cc1C(F)F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635230 US11814367, Compound 679 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635230&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349926 CC(C)c1c(C)cc(cc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635229 US11814367, Compound 678::US11814367, Compound 680 Glycogen [starch] synthase, liver 93000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635229&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349927 CC1(CCC1)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635232 US11814367, Compound 681 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635232&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349928 Cc1nnn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)NC(c2ccccc2)c2cc(C)c(C3CC3)c(F)c2)n1 InChI=1S/C26H28F2N6O2/c1-15-10-19(11-21(28)24(15)17-8-9-17)25(18-6-4-3-5-7-18)29-26(36)22-12-20(27)13-33(22)23(35)14-34-31-16(2)30-32-34/h3-7,10-11,17,20,22,25H,8-9,12-14H2,1-2H3,(H,29,36)/t20-,22+,25?/m1/s1 VDFCLPVCJFPKLU-BOQQILRGSA-N 635233 US11814367, Compound 682 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635233&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349929 CC(C)(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 635236 US11814367, Compound 685 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635236&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349930 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1cccc(c1)-c1ccn[nH]1 635237 US11814367, Compound 686 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635237&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349931 CC(C)c1ccc(nc1F)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(C)=O)c1cccc(c1)-c1ccn[nH]1 635241 US11814367, Compound 690 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635241&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349932 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nn(C)c(=O)n1C)c1ccccc1 InChI=1S/C26H31FN6O3/c1-16(2)18-10-11-20(28-14-18)24(17-8-6-5-7-9-17)29-25(35)21-12-19(27)15-33(21)23(34)13-22-30-32(4)26(36)31(22)3/h5-11,14,16,19,21,24H,12-13,15H2,1-4H3,(H,29,35)/t19-,21+,24+/m1/s1 WIIQFKWWPCJUIB-IZIIKQMZSA-N 635260 US11814367, Compound 710 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635260&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349933 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(nn1)N1CCC1)c1ccccc1 InChI=1S/C27H32FN7O2/c1-18(2)20-9-10-22(29-14-20)26(19-7-4-3-5-8-19)30-27(37)23-13-21(28)15-35(23)25(36)17-34-16-24(31-32-34)33-11-6-12-33/h3-5,7-10,14,16,18,21,23,26H,6,11-13,15,17H2,1-2H3,(H,30,37)/t21-,23+,26+/m1/s1 GOEUXQHPMGKROJ-JJTGBXKASA-N 635261 US11814367, Compound 711 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635261 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635261&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349934 Cn1c(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)noc1=O InChI=1S/C25H25F2N5O4/c1-31-20(30-36-25(31)35)12-21(33)32-13-16(26)11-19(32)24(34)29-22(15-5-3-2-4-6-15)18-10-9-17(14-7-8-14)23(27)28-18/h2-6,9-10,14,16,19,22H,7-8,11-13H2,1H3,(H,29,34)/t16-,19+,22+/m1/s1 BSPTWQJTDQEGOQ-WVBUVRCRSA-N 635269 US11814367, Compound 719 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635269 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635269&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349935 Cn1nc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)n(C)c1=O InChI=1S/C26H28F2N6O3/c1-32-21(31-33(2)26(32)37)13-22(35)34-14-17(27)12-20(34)25(36)30-23(16-6-4-3-5-7-16)19-11-10-18(15-8-9-15)24(28)29-19/h3-7,10-11,15,17,20,23H,8-9,12-14H2,1-2H3,(H,30,36)/t17-,20+,23+/m1/s1 QYWLJUIAJGUTLD-MONBJTKQSA-N 635272 US11814367, Compound 722 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635272 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635272&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349936 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cccn1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C25H25F2N5O2/c26-18-13-21(32(14-18)22(33)15-31-12-4-11-28-31)25(34)30-23(17-5-2-1-3-6-17)20-10-9-19(16-7-8-16)24(27)29-20/h1-6,9-12,16,18,21,23H,7-8,13-15H2,(H,30,34)/t18-,21+,23+/m1/s1 KIFCYLGTMFDESX-JZWVFAODSA-N 635273 US11814367, Compound 723 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635273&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349937 Cc1ccnn1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C26H27F2N5O2/c1-16-11-12-29-33(16)15-23(34)32-14-19(27)13-22(32)26(35)31-24(18-5-3-2-4-6-18)21-10-9-20(17-7-8-17)25(28)30-21/h2-6,9-12,17,19,22,24H,7-8,13-15H2,1H3,(H,31,35)/t19-,22+,24+/m1/s1 PICVTTDMDKKOBO-UCFCWBNQSA-N 635274 US11814367, Compound 724 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635274 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635274&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349938 FC(F)c1ccnn1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C26H25F4N5O2/c27-17-12-21(34(13-17)22(36)14-35-20(24(28)29)10-11-31-35)26(37)33-23(16-4-2-1-3-5-16)19-9-8-18(15-6-7-15)25(30)32-19/h1-5,8-11,15,17,21,23-24H,6-7,12-14H2,(H,33,37)/t17-,21+,23+/m1/s1 DMBNVTPVMJQEGF-FHZYATBESA-N 635275 US11814367, Compound 725 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635275&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349939 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cc(nn1)N1CCC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C27H29F2N7O2/c28-19-13-22(36(14-19)24(37)16-35-15-23(32-33-35)34-11-4-12-34)27(38)31-25(18-5-2-1-3-6-18)21-10-9-20(17-7-8-17)26(29)30-21/h1-3,5-6,9-10,15,17,19,22,25H,4,7-8,11-14,16H2,(H,31,38)/t19-,22+,25+/m1/s1 XGTDLYLKLWYWQH-WPWBMXPQSA-N 635276 US11814367, Compound 726 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635276&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349940 F[C@@H]1C[C@H](N(C1)C(=O)Cn1ccc(=O)[nH]c1=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 635277 US11814367, Compound 727 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635277&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349941 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cc(cn1)C(F)(F)F)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C26H24F5N5O2/c27-18-10-21(36(13-18)22(37)14-35-12-17(11-32-35)26(29,30)31)25(38)34-23(16-4-2-1-3-5-16)20-9-8-19(15-6-7-15)24(28)33-20/h1-5,8-9,11-12,15,18,21,23H,6-7,10,13-14H2,(H,34,38)/t18-,21+,23+/m1/s1 RCRPLCTWHKFCBS-JZWVFAODSA-N 635278 US11814367, Compound 728 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635278&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349942 FC(F)c1ccn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)n1 InChI=1S/C26H25F4N5O2/c27-17-12-21(35(13-17)22(36)14-34-11-10-20(33-34)24(28)29)26(37)32-23(16-4-2-1-3-5-16)19-9-8-18(15-6-7-15)25(30)31-19/h1-5,8-11,15,17,21,23-24H,6-7,12-14H2,(H,32,37)/t17-,21+,23+/m1/s1 RAUQYYFJTGCLSS-FHZYATBESA-N 635279 US11814367, Compound 729 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635279 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635279&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349943 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ccc[nH]c1=O)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 635281 US11814367, Compound 731 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635281 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635281&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349944 Cc1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)c[nH]c1=O 635282 US11814367, Compound 732 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635282 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635282&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349945 CCn1c(=O)c(C)cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)c1=O InChI=1S/C29H31F2N5O4/c1-3-35-28(39)17(2)14-34(29(35)40)16-24(37)36-15-20(30)13-23(36)27(38)33-25(19-7-5-4-6-8-19)22-12-11-21(18-9-10-18)26(31)32-22/h4-8,11-12,14,18,20,23,25H,3,9-10,13,15-16H2,1-2H3,(H,33,38)/t20-,23+,25+/m1/s1 MBBHIEMQRGXSNP-PBXXJUDPSA-N 635283 US11814367, Compound 733 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635283&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349946 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ccc(=O)[nH]c1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 635284 US11814367, Compound 734 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635284&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349947 CCn1c(=O)ccn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)c1=O InChI=1S/C28H29F2N5O4/c1-2-34-23(36)12-13-33(28(34)39)16-24(37)35-15-19(29)14-22(35)27(38)32-25(18-6-4-3-5-7-18)21-11-10-20(17-8-9-17)26(30)31-21/h3-7,10-13,17,19,22,25H,2,8-9,14-16H2,1H3,(H,32,38)/t19-,22+,25+/m1/s1 QJFBOFFNQUAYLE-WPWBMXPQSA-N 635285 US11814367, Compound 735 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635285 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635285&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349948 CCn1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)ccc1=O InChI=1S/C29H30F2N4O3/c1-2-34-16-18(8-13-25(34)36)14-26(37)35-17-21(30)15-24(35)29(38)33-27(20-6-4-3-5-7-20)23-12-11-22(19-9-10-19)28(31)32-23/h3-8,11-13,16,19,21,24,27H,2,9-10,14-15,17H2,1H3,(H,33,38)/t21-,24+,27+/m1/s1 MTFFAMAEAXVDSL-QURRFSBHSA-N 635286 US11814367, Compound 736 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635286&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349949 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@H](CC(N)=O)NC(C)=O)c1ccccc1 InChI=1S/C27H32F2N4O4/c1-15(2)20-10-9-18(11-21(20)29)25(17-7-5-4-6-8-17)32-26(36)23-12-19(28)14-33(23)27(37)22(13-24(30)35)31-16(3)34/h4-11,15,19,22-23,25H,12-14H2,1-3H3,(H2,30,35)(H,31,34)(H,32,36)/t19-,22+,23+,25+/m1/s1 VFVFKJFEAGTPHD-SXPAWZJZSA-N 635315 US11814367, Compound 765 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635315&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349950 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)n1cnnn1)c1ccccc1 InChI=1S/C25H28F2N6O2/c1-15(2)20-10-9-18(11-21(20)27)23(17-7-5-4-6-8-17)29-24(34)22-12-19(26)13-32(22)25(35)16(3)33-14-28-30-31-33/h4-11,14-16,19,22-23H,12-13H2,1-3H3,(H,29,34)/t16?,19-,22+,23+/m1/s1 PIBRYCOTHDGQDP-YKTIAARLSA-N 635316 US11814367, Compound 766::US11814367, Compound 767 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635316&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349951 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)n1cnnn1)c1ccccc1 InChI=1S/C25H28F2N6O2/c1-15(2)20-10-9-18(11-21(20)27)23(17-7-5-4-6-8-17)29-24(34)22-12-19(26)13-32(22)25(35)16(3)33-14-28-30-31-33/h4-11,14-16,19,22-23H,12-13H2,1-3H3,(H,29,34)/t16?,19-,22+,23+/m1/s1 PIBRYCOTHDGQDP-YKTIAARLSA-N 635316 US11814367, Compound 766::US11814367, Compound 767 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635316&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349952 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)n1ccnc1)c1ccccc1 InChI=1S/C27H30F2N4O2/c1-17(2)22-10-9-20(13-23(22)29)25(19-7-5-4-6-8-19)31-26(34)24-14-21(28)15-33(24)27(35)18(3)32-12-11-30-16-32/h4-13,16-18,21,24-25H,14-15H2,1-3H3,(H,31,34)/t18?,21-,24+,25+/m1/s1 KNEXPWDULWDGKL-UBZUIKNHSA-N 635318 US11814367, Compound 768::US11814367, Compound 771 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635318&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349953 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)c1cnn[nH]1)c1ccccc1 635319 US11814367, Compound 769::US11814367, Compound 770 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635319&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349954 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)c1cnn[nH]1)c1ccccc1 635319 US11814367, Compound 769::US11814367, Compound 770 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635319&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349955 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)n1ccnc1)c1ccccc1 InChI=1S/C27H30F2N4O2/c1-17(2)22-10-9-20(13-23(22)29)25(19-7-5-4-6-8-19)31-26(34)24-14-21(28)15-33(24)27(35)18(3)32-12-11-30-16-32/h4-13,16-18,21,24-25H,14-15H2,1-3H3,(H,31,34)/t18?,21-,24+,25+/m1/s1 KNEXPWDULWDGKL-UBZUIKNHSA-N 635318 US11814367, Compound 768::US11814367, Compound 771 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635318&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349956 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1S(=O)(=O)Cc1cnn[nH]1)c1ccccc1 635322 US11814367, Compound 772 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635322&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349957 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(O)c1cnn[nH]1)c1ccccc1 635323 US11814367, Compound 773::US11814367, Compound 774 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635323&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349958 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(O)c1cnn[nH]1)c1ccccc1 635323 US11814367, Compound 773::US11814367, Compound 774 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635323&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349959 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C)c(=O)n(C)c1=O)c1ccccc1 InChI=1S/C28H31F2N5O4/c1-16(2)20-10-11-21(31-25(20)30)24(18-8-6-5-7-9-18)32-26(37)22-12-19(29)14-35(22)23(36)15-34-13-17(3)27(38)33(4)28(34)39/h5-11,13,16,19,22,24H,12,14-15H2,1-4H3,(H,32,37)/t19-,22+,24+/m1/s1 MIQLBDJOBGVDGS-UCFCWBNQSA-N 634937 US11814367, Compound 386::US11814367, Compound 777 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634937&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349960 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nn(C)c(=O)n1C)c1ccccc1 InChI=1S/C26H30F2N6O3/c1-15(2)18-10-11-19(29-24(18)28)23(16-8-6-5-7-9-16)30-25(36)20-12-17(27)14-34(20)22(35)13-21-31-33(4)26(37)32(21)3/h5-11,15,17,20,23H,12-14H2,1-4H3,(H,30,36)/t17-,20+,23+/m1/s1 XSELZAMLHWMLMZ-MONBJTKQSA-N 635329 US11814367, Compound 779 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635329&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349961 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCn1nc2ccccn2c1=O)c1ccccc1 InChI=1S/C29H30F2N6O3/c1-18(2)21-11-12-22(32-27(21)31)26(19-8-4-3-5-9-19)33-28(39)23-16-20(30)17-36(23)25(38)13-15-37-29(40)35-14-7-6-10-24(35)34-37/h3-12,14,18,20,23,26H,13,15-17H2,1-2H3,(H,33,39)/t20-,23+,26+/m1/s1 YFRNYWFYAVHGMV-SEIBCYHCSA-N 635330 US11814367, Compound 780 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635330&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349962 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cccn1)c1ccccc1 InChI=1S/C25H27F2N5O2/c1-16(2)19-9-10-20(29-24(19)27)23(17-7-4-3-5-8-17)30-25(34)21-13-18(26)14-32(21)22(33)15-31-12-6-11-28-31/h3-12,16,18,21,23H,13-15H2,1-2H3,(H,30,34)/t18-,21+,23+/m1/s1 GRBIMBAEJPYSOO-JZWVFAODSA-N 635331 US11814367, Compound 781 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635331&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349963 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nccc1C)c1ccccc1 InChI=1S/C26H29F2N5O2/c1-16(2)20-9-10-21(30-25(20)28)24(18-7-5-4-6-8-18)31-26(35)22-13-19(27)14-32(22)23(34)15-33-17(3)11-12-29-33/h4-12,16,19,22,24H,13-15H2,1-3H3,(H,31,35)/t19-,22+,24+/m1/s1 AIGHNESKYHFFNI-UCFCWBNQSA-N 635332 US11814367, Compound 782 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635332&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349964 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nccc1C(F)F)c1ccccc1 InChI=1S/C26H27F4N5O2/c1-15(2)18-8-9-19(32-25(18)30)23(16-6-4-3-5-7-16)33-26(37)21-12-17(27)13-34(21)22(36)14-35-20(24(28)29)10-11-31-35/h3-11,15,17,21,23-24H,12-14H2,1-2H3,(H,33,37)/t17-,21+,23+/m1/s1 JQFIOXJEIMCNNR-FHZYATBESA-N 635333 US11814367, Compound 783 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635333&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349965 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c[nH]c(=O)c(C)c1)c1ccccc1 635334 US11814367, Compound 784 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635334&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349966 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccc(=O)[nH]c1=O)c1ccccc1 635335 US11814367, Compound 785 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635335&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349967 CCn1c(=O)ccn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C(C)C)c(F)n2)c1=O InChI=1S/C28H31F2N5O4/c1-4-34-23(36)12-13-33(28(34)39)16-24(37)35-15-19(29)14-22(35)27(38)32-25(18-8-6-5-7-9-18)21-11-10-20(17(2)3)26(30)31-21/h5-13,17,19,22,25H,4,14-16H2,1-3H3,(H,32,38)/t19-,22+,25+/m1/s1 ROGLZVQNWXCUDF-WPWBMXPQSA-N 635336 US11814367, Compound 786 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635336&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349968 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(nn1)N1CCC1)c1ccccc1 InChI=1S/C27H31F2N7O2/c1-17(2)20-9-10-21(30-26(20)29)25(18-7-4-3-5-8-18)31-27(38)22-13-19(28)14-36(22)24(37)16-35-15-23(32-33-35)34-11-6-12-34/h3-5,7-10,15,17,19,22,25H,6,11-14,16H2,1-2H3,(H,31,38)/t19-,22+,25+/m1/s1 VRBFPNWSVWWGKP-WPWBMXPQSA-N 635337 US11814367, Compound 787 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635337&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349969 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(cn1)C(F)(F)F)c1ccccc1 InChI=1S/C26H26F5N5O2/c1-15(2)19-8-9-20(33-24(19)28)23(16-6-4-3-5-7-16)34-25(38)21-10-18(27)13-36(21)22(37)14-35-12-17(11-32-35)26(29,30)31/h3-9,11-12,15,18,21,23H,10,13-14H2,1-2H3,(H,34,38)/t18-,21+,23+/m1/s1 UJWHNDXHIDPBAG-JZWVFAODSA-N 635338 US11814367, Compound 788 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635338&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349970 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccc(n1)C(F)F)c1ccccc1 InChI=1S/C26H27F4N5O2/c1-15(2)18-8-9-19(31-25(18)30)23(16-6-4-3-5-7-16)32-26(37)21-12-17(27)13-35(21)22(36)14-34-11-10-20(33-34)24(28)29/h3-11,15,17,21,23-24H,12-14H2,1-2H3,(H,32,37)/t17-,21+,23+/m1/s1 ZDQPWVDNHXOANU-FHZYATBESA-N 635339 US11814367, Compound 789 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635339&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349971 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccc(n1)C(F)(F)F)c1ccccc1 InChI=1S/C26H26F5N5O2/c1-15(2)18-8-9-19(32-24(18)28)23(16-6-4-3-5-7-16)33-25(38)20-12-17(27)13-36(20)22(37)14-35-11-10-21(34-35)26(29,30)31/h3-11,15,17,20,23H,12-14H2,1-2H3,(H,33,38)/t17-,20+,23+/m1/s1 OGZIUDPLWQZKNK-MONBJTKQSA-N 635340 US11814367, Compound 790 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635340&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349972 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccc(=O)[nH]c1)c1ccccc1 635341 US11814367, Compound 791 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635341&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349973 CCn1cc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C(C)C)c(F)n2)ccc1=O InChI=1S/C29H32F2N4O3/c1-4-34-16-19(10-13-25(34)36)14-26(37)35-17-21(30)15-24(35)29(38)33-27(20-8-6-5-7-9-20)23-12-11-22(18(2)3)28(31)32-23/h5-13,16,18,21,24,27H,4,14-15,17H2,1-3H3,(H,33,38)/t21-,24+,27+/m1/s1 WTIKNYAIDCYZBR-QURRFSBHSA-N 635342 US11814367, Compound 792 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635342&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349974 CC(C)c1ccc(nc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccc[nH]c1=O)c1ccccc1 635343 US11814367, Compound 793 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635343&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349975 CCn1c(=O)c(C)cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C(C)C)c(F)n2)c1=O InChI=1S/C29H33F2N5O4/c1-5-35-28(39)18(4)14-34(29(35)40)16-24(37)36-15-20(30)13-23(36)27(38)33-25(19-9-7-6-8-10-19)22-12-11-21(17(2)3)26(31)32-22/h6-12,14,17,20,23,25H,5,13,15-16H2,1-4H3,(H,33,38)/t20-,23+,25+/m1/s1 JWHVRFIDHDYJPC-PBXXJUDPSA-N 635344 US11814367, Compound 794 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635344&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349976 CCn1cccc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C(C)C)c(F)n2)c1=O InChI=1S/C29H32F2N4O3/c1-4-34-14-8-11-20(29(34)38)15-25(36)35-17-21(30)16-24(35)28(37)33-26(19-9-6-5-7-10-19)23-13-12-22(18(2)3)27(31)32-23/h5-14,18,21,24,26H,4,15-17H2,1-3H3,(H,33,37)/t21-,24+,26+/m1/s1 GRMXQLSMDGCEBR-DSBYRVASSA-N 635345 US11814367, Compound 795 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635345&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349977 CC(C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1)n1cnc2ccccc12 InChI=1S/C31H30F2N4O2/c1-19(37-18-34-26-9-5-6-10-27(26)37)31(39)36-17-23(32)16-28(36)30(38)35-29(21-7-3-2-4-8-21)22-13-14-24(20-11-12-20)25(33)15-22/h2-10,13-15,18-20,23,28-29H,11-12,16-17H2,1H3,(H,35,38)/t19?,23-,28+,29+/m1/s1 JDNCGEICQPGCJQ-CDJUCRPNSA-N 635359 US11814367, Compound 809::US11814367, Compound 810 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635359&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349978 CC(C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)c1)n1cnc2ccccc12 InChI=1S/C31H30F2N4O2/c1-19(37-18-34-26-9-5-6-10-27(26)37)31(39)36-17-23(32)16-28(36)30(38)35-29(21-7-3-2-4-8-21)22-13-14-24(20-11-12-20)25(33)15-22/h2-10,13-15,18-20,23,28-29H,11-12,16-17H2,1H3,(H,35,38)/t19?,23-,28+,29+/m1/s1 JDNCGEICQPGCJQ-CDJUCRPNSA-N 635359 US11814367, Compound 809::US11814367, Compound 810 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=635359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=635359&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349396 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 634552 US11814367, Compound 1 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634552 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634552&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349397 CC(C)c1ccc(cc1)[C@@H](NC(=O)C1C[C@@H](F)CN1C(=O)CCN(C(C)=O)c1ccn(C)n1)c1ccccc1 InChI=1S/C30H36FN5O3/c1-20(2)22-10-12-24(13-11-22)29(23-8-6-5-7-9-23)32-30(39)26-18-25(31)19-36(26)28(38)15-17-35(21(3)37)27-14-16-34(4)33-27/h5-14,16,20,25-26,29H,15,17-19H2,1-4H3,(H,32,39)/t25-,26?,29+/m1/s1 WEUGMFTXIDDNMT-VJHAGTGTSA-N 634553 US11814367, Compound 2 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634553 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634553&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349398 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@]12COC[C@@H]1CN(C2)C(C)=O)c1ccccc1 InChI=1S/C30H36FN3O4/c1-19(2)21-9-11-23(12-10-21)27(22-7-5-4-6-8-22)32-28(36)26-13-25(31)15-34(26)29(37)30-17-33(20(3)35)14-24(30)16-38-18-30/h4-12,19,24-27H,13-18H2,1-3H3,(H,32,36)/t24-,25+,26-,27-,30-/m0/s1 IYYBJXYLGVLORG-JAUZHHQJSA-N 634554 US11814367, Compound 3 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634554 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634554&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349399 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CNC(=O)[C@]11CCN(C1)C(C)=O)c1ccccc1 InChI=1S/C31H37FN4O4/c1-19(2)21-9-11-23(12-10-21)27(22-7-5-4-6-8-22)34-28(38)26-15-24(32)17-36(26)29(39)25-16-33-30(40)31(25)13-14-35(18-31)20(3)37/h4-12,19,24-27H,13-18H2,1-3H3,(H,33,40)(H,34,38)/t24-,25?,26+,27+,31+/m1/s1 ZURSKQIQXOZYIU-BCDQZJFBSA-N 634557 US11814367, Compound 6 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634557&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349400 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CC1CCCC11CN(C1)C(C)=O)c1ccccc1 InChI=1S/C32H40FN3O3/c1-21(2)23-11-13-25(14-12-23)30(24-8-5-4-6-9-24)34-31(39)28-17-27(33)18-36(28)29(38)16-26-10-7-15-32(26)19-35(20-32)22(3)37/h4-6,8-9,11-14,21,26-28,30H,7,10,15-20H2,1-3H3,(H,34,39)/t26?,27-,28+,30+/m1/s1 BRGOLOCKDACCKG-PHNBDNRTSA-N 634558 US11814367, Compound 7 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634558&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349401 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@H]1CNC(=O)O1)c1ccccc1 InChI=1S/C25H28FN3O4/c1-15(2)16-8-10-18(11-9-16)22(17-6-4-3-5-7-17)28-23(30)20-12-19(26)14-29(20)24(31)21-13-27-25(32)33-21/h3-11,15,19-22H,12-14H2,1-2H3,(H,27,32)(H,28,30)/t19-,20+,21+,22+/m1/s1 PKWOVVQMFQCVAU-MLNNCEHLSA-N 634559 US11814367, Compound 8 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634559&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349402 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnnn1)c1ccccc1 InChI=1S/C24H27FN6O2/c1-16(2)17-8-10-19(11-9-17)23(18-6-4-3-5-7-18)27-24(33)21-12-20(25)13-31(21)22(32)14-30-15-26-28-29-30/h3-11,15-16,20-21,23H,12-14H2,1-2H3,(H,27,33)/t20-,21+,23+/m1/s1 ATPAPPLCLWGQOU-GIWBLDEGSA-N 634560 US11814367, Compound 9 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634560&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349403 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(C)o1)c1ccccc1 InChI=1S/C26H29FN4O3/c1-16(2)18-9-11-20(12-10-18)25(19-7-5-4-6-8-19)28-26(33)22-13-21(27)15-31(22)24(32)14-23-30-29-17(3)34-23/h4-12,16,21-22,25H,13-15H2,1-3H3,(H,28,33)/t21-,22+,25+/m1/s1 KPUZTSQFAMAJFV-SLSDLSHTSA-N 634561 US11814367, Compound 10 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634561&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349404 CC(C)c1ccc(cc1)[C@@H](NC(=O)C1C[C@@H](F)CN1C(=O)CCn1ccnn1)c1ccccc1 InChI=1S/C26H30FN5O2/c1-18(2)19-8-10-21(11-9-19)25(20-6-4-3-5-7-20)29-26(34)23-16-22(27)17-32(23)24(33)12-14-31-15-13-28-30-31/h3-11,13,15,18,22-23,25H,12,14,16-17H2,1-2H3,(H,29,34)/t22-,23?,25+/m1/s1 FMFAJVBAVHDCOP-XOTJBQCQSA-N 634562 US11814367, Compound 11 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634562&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349405 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCC#N)c1ccccc1 InChI=1S/C25H28FN3O2/c1-17(2)18-10-12-20(13-11-18)24(19-7-4-3-5-8-19)28-25(31)22-15-21(26)16-29(22)23(30)9-6-14-27/h3-5,7-8,10-13,17,21-22,24H,6,9,15-16H2,1-2H3,(H,28,31)/t21-,22+,24+/m1/s1 UBIBFZLLDRWBBX-GPXNEJASSA-N 634564 US11814367, Compound 13 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634564&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349406 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CS(C)(=O)=O)c1ccccc1 InChI=1S/C24H29FN2O4S/c1-16(2)17-9-11-19(12-10-17)23(18-7-5-4-6-8-18)26-24(29)21-13-20(25)14-27(21)22(28)15-32(3,30)31/h4-12,16,20-21,23H,13-15H2,1-3H3,(H,26,29)/t20-,21+,23+/m1/s1 FCWVLPXWVHQMPR-GIWBLDEGSA-N 634565 US11814367, Compound 14 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634565&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349407 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cscn1)c1ccccc1 InChI=1S/C26H28FN3O2S/c1-17(2)18-8-10-20(11-9-18)25(19-6-4-3-5-7-19)29-26(32)23-12-21(27)14-30(23)24(31)13-22-15-33-16-28-22/h3-11,15-17,21,23,25H,12-14H2,1-2H3,(H,29,32)/t21-,23+,25+/m1/s1 GONZJUNDBTXIFF-VTZPFEBOSA-N 634566 US11814367, Compound 15 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634566&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349408 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cncn1)c1ccccc1 InChI=1S/C25H28FN5O2/c1-17(2)18-8-10-20(11-9-18)24(19-6-4-3-5-7-19)29-25(33)22-12-21(26)13-31(22)23(32)14-30-16-27-15-28-30/h3-11,15-17,21-22,24H,12-14H2,1-2H3,(H,29,33)/t21-,22+,24+/m1/s1 FRBNKHBUOLGIBD-GPXNEJASSA-N 634567 US11814367, Compound 16 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634567&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349409 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nccn1)c1ccccc1 InChI=1S/C25H28FN5O2/c1-17(2)18-8-10-20(11-9-18)24(19-6-4-3-5-7-19)29-25(33)22-14-21(26)15-30(22)23(32)16-31-27-12-13-28-31/h3-13,17,21-22,24H,14-16H2,1-2H3,(H,29,33)/t21-,22+,24+/m1/s1 VWXPWCMAZIAOBA-GPXNEJASSA-N 634568 US11814367, Compound 17 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634568&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349410 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c[nH]cn1)c1ccccc1 634569 US11814367, Compound 18 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634569&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349411 CC(C)c1ccc(cc1)[C@@H](NC(=O)C1C[C@@H](F)CN1C(=O)COc1cccnn1)c1ccccc1 InChI=1S/C27H29FN4O3/c1-18(2)19-10-12-21(13-11-19)26(20-7-4-3-5-8-20)30-27(34)23-15-22(28)16-32(23)25(33)17-35-24-9-6-14-29-31-24/h3-14,18,22-23,26H,15-17H2,1-2H3,(H,30,34)/t22-,23?,26+/m1/s1 FHNRAFMZJWAIJA-SATOSQONSA-N 634572 US11814367, Compound 21 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634572&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349412 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cccn1)c1ccccc1 InChI=1S/C26H29FN4O2/c1-18(2)19-9-11-21(12-10-19)25(20-7-4-3-5-8-20)29-26(33)23-15-22(27)16-31(23)24(32)17-30-14-6-13-28-30/h3-14,18,22-23,25H,15-17H2,1-2H3,(H,29,33)/t22-,23+,25+/m1/s1 WWBJWTCVIFGDEJ-CUYJMHBOSA-N 634573 US11814367, Compound 22::US11814367, Compound 221 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634573&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349413 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccnc1)c1ccccc1 InChI=1S/C26H29FN4O2/c1-18(2)19-8-10-21(11-9-19)25(20-6-4-3-5-7-20)29-26(33)23-14-22(27)15-31(23)24(32)16-30-13-12-28-17-30/h3-13,17-18,22-23,25H,14-16H2,1-2H3,(H,29,33)/t22-,23+,25+/m1/s1 PZPRCZPKEWBYEN-CUYJMHBOSA-N 634574 US11814367, Compound 23 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634574&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349414 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)n1cnnn1)c1ccccc1 InChI=1S/C25H29FN6O2/c1-16(2)18-9-11-20(12-10-18)23(19-7-5-4-6-8-19)28-24(33)22-13-21(26)14-31(22)25(34)17(3)32-15-27-29-30-32/h4-12,15-17,21-23H,13-14H2,1-3H3,(H,28,33)/t17?,21-,22+,23+/m1/s1 IBSBOSZNKUZZNQ-KNFJIDDQSA-N 634575 US11814367, Compound 24 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634575&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349415 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1(C)COC1)c1ccccc1 InChI=1S/C26H31FN2O3/c1-17(2)18-9-11-20(12-10-18)23(19-7-5-4-6-8-19)28-24(30)22-13-21(27)14-29(22)25(31)26(3)15-32-16-26/h4-12,17,21-23H,13-16H2,1-3H3,(H,28,30)/t21-,22+,23+/m1/s1 WRKHCWXFNOFXMR-VJBWXMMDSA-N 634576 US11814367, Compound 25 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634576&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349416 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnccn1)c1ccccc1 InChI=1S/C27H29FN4O2/c1-18(2)19-8-10-21(11-9-19)26(20-6-4-3-5-7-20)31-27(34)24-14-22(28)17-32(24)25(33)15-23-16-29-12-13-30-23/h3-13,16,18,22,24,26H,14-15,17H2,1-2H3,(H,31,34)/t22-,24+,26+/m1/s1 VEWDJIOGFJKHSJ-CWDLOFLHSA-N 634577 US11814367, Compound 26::US11814367, Compound 28 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634577&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349417 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cncnc1)c1ccccc1 InChI=1S/C27H29FN4O2/c1-18(2)20-8-10-22(11-9-20)26(21-6-4-3-5-7-21)31-27(34)24-13-23(28)16-32(24)25(33)12-19-14-29-17-30-15-19/h3-11,14-15,17-18,23-24,26H,12-13,16H2,1-2H3,(H,31,34)/t23-,24+,26+/m1/s1 PIEAWXLUCMZBLW-USZFVNFHSA-N 634578 US11814367, Compound 27 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634578&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349418 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnccn1)c1ccccc1 InChI=1S/C27H29FN4O2/c1-18(2)19-8-10-21(11-9-19)26(20-6-4-3-5-7-20)31-27(34)24-14-22(28)17-32(24)25(33)15-23-16-29-12-13-30-23/h3-13,16,18,22,24,26H,14-15,17H2,1-2H3,(H,31,34)/t22-,24+,26+/m1/s1 VEWDJIOGFJKHSJ-CWDLOFLHSA-N 634577 US11814367, Compound 26::US11814367, Compound 28 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634577&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349419 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1noc(C)n1)c1ccccc1 InChI=1S/C26H29FN4O3/c1-16(2)18-9-11-20(12-10-18)25(19-7-5-4-6-8-19)29-26(33)22-13-21(27)15-31(22)24(32)14-23-28-17(3)34-30-23/h4-12,16,21-22,25H,13-15H2,1-3H3,(H,29,33)/t21-,22+,25+/m1/s1 JGRRHORGKJXOSL-SLSDLSHTSA-N 634580 US11814367, Compound 29 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634580&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349420 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nc(C)no1)c1ccccc1 InChI=1S/C26H29FN4O3/c1-16(2)18-9-11-20(12-10-18)25(19-7-5-4-6-8-19)29-26(33)22-13-21(27)15-31(22)24(32)14-23-28-17(3)30-34-23/h4-12,16,21-22,25H,13-15H2,1-3H3,(H,29,33)/t21-,22+,25+/m1/s1 CCXREDQBJCYFBY-SLSDLSHTSA-N 634582 US11814367, Compound 31 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634582&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349421 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccncc1=O)c1ccccc1 InChI=1S/C27H29FN4O3/c1-18(2)19-8-10-21(11-9-19)26(20-6-4-3-5-7-20)30-27(35)23-14-22(28)16-32(23)25(34)17-31-13-12-29-15-24(31)33/h3-13,15,18,22-23,26H,14,16-17H2,1-2H3,(H,30,35)/t22-,23+,26+/m1/s1 STAOVCVCZRAASD-UMFSSWHCSA-N 634583 US11814367, Compound 32 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634583&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349422 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)n1ccnn1)c1ccccc1 InChI=1S/C26H30FN5O2/c1-17(2)19-9-11-21(12-10-19)24(20-7-5-4-6-8-20)29-25(33)23-15-22(27)16-31(23)26(34)18(3)32-14-13-28-30-32/h4-14,17-18,22-24H,15-16H2,1-3H3,(H,29,33)/t18?,22-,23+,24+/m1/s1 QTECECWKPTUMBL-IGBKMDQPSA-N 634584 US11814367, Compound 33 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634584&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349423 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)n1cncn1)c1ccccc1 InChI=1S/C26H30FN5O2/c1-17(2)19-9-11-21(12-10-19)24(20-7-5-4-6-8-20)30-25(33)23-13-22(27)14-31(23)26(34)18(3)32-16-28-15-29-32/h4-12,15-18,22-24H,13-14H2,1-3H3,(H,30,33)/t18?,22-,23+,24+/m1/s1 XOMVKQICOFKJPT-IGBKMDQPSA-N 634585 US11814367, Compound 34 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634585&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349424 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCn1cncn1)c1ccccc1 InChI=1S/C26H30FN5O2/c1-18(2)19-8-10-21(11-9-19)25(20-6-4-3-5-7-20)30-26(34)23-14-22(27)15-32(23)24(33)12-13-31-17-28-16-29-31/h3-11,16-18,22-23,25H,12-15H2,1-2H3,(H,30,34)/t22-,23+,25+/m1/s1 BLCGUDLTZVCQMA-CUYJMHBOSA-N 634586 US11814367, Compound 35 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634586&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349425 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccc(F)cn1)c1ccccc1 InChI=1S/C28H29F2N3O2/c1-18(2)19-8-10-21(11-9-19)27(20-6-4-3-5-7-20)32-28(35)25-14-23(30)17-33(25)26(34)15-24-13-12-22(29)16-31-24/h3-13,16,18,23,25,27H,14-15,17H2,1-2H3,(H,32,35)/t23-,25+,27+/m1/s1 KCTUVAPTXOJQSR-NIYJGHKDSA-N 634587 US11814367, Compound 36 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634587&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349426 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccccn1)c1ccccc1 InChI=1S/C28H30FN3O2/c1-19(2)20-11-13-22(14-12-20)27(21-8-4-3-5-9-21)31-28(34)25-16-23(29)18-32(25)26(33)17-24-10-6-7-15-30-24/h3-15,19,23,25,27H,16-18H2,1-2H3,(H,31,34)/t23-,25+,27+/m1/s1 WHAFIVQIADSJRF-NIYJGHKDSA-N 634588 US11814367, Compound 37::US11814367, Compound 38 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634588&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349427 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccccn1)c1ccccc1 InChI=1S/C28H30FN3O2/c1-19(2)20-11-13-22(14-12-20)27(21-8-4-3-5-9-21)31-28(34)25-16-23(29)18-32(25)26(33)17-24-10-6-7-15-30-24/h3-15,19,23,25,27H,16-18H2,1-2H3,(H,31,34)/t23-,25+,27+/m1/s1 WHAFIVQIADSJRF-NIYJGHKDSA-N 634588 US11814367, Compound 37::US11814367, Compound 38 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634588&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349428 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cc(C)no1)c1ccccc1 InChI=1S/C27H30FN3O3/c1-17(2)19-9-11-21(12-10-19)26(20-7-5-4-6-8-20)29-27(33)24-14-22(28)16-31(24)25(32)15-23-13-18(3)30-34-23/h4-13,17,22,24,26H,14-16H2,1-3H3,(H,29,33)/t22-,24+,26+/m1/s1 VEXYZKFELKDOCB-CWDLOFLHSA-N 634591 US11814367, Compound 40 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634591&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349429 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnc(C)s1)c1ccccc1 InChI=1S/C27H30FN3O2S/c1-17(2)19-9-11-21(12-10-19)26(20-7-5-4-6-8-20)30-27(33)24-13-22(28)16-31(24)25(32)14-23-15-29-18(3)34-23/h4-12,15,17,22,24,26H,13-14,16H2,1-3H3,(H,30,33)/t22-,24+,26+/m1/s1 LRUWSSUAVQSYMO-CWDLOFLHSA-N 634592 US11814367, Compound 41 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634592&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349430 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)n1ccnc1)c1ccccc1 InChI=1S/C27H31FN4O2/c1-18(2)20-9-11-22(12-10-20)25(21-7-5-4-6-8-21)30-26(33)24-15-23(28)16-32(24)27(34)19(3)31-14-13-29-17-31/h4-14,17-19,23-25H,15-16H2,1-3H3,(H,30,33)/t19?,23-,24+,25+/m1/s1 FQWZAOGEBMRWSL-YXEUUWGCSA-N 634595 US11814367, Compound 44 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634595&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349431 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1cn[nH]c1)c1ccccc1 634597 US11814367, Compound 46 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634597&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349432 CC(C)c1ccc(cc1)[C@@H](NC(=O)C1C[C@@H](F)CN1C(=O)COc1cccnc1)c1ccccc1 InChI=1S/C28H30FN3O3/c1-19(2)20-10-12-22(13-11-20)27(21-7-4-3-5-8-21)31-28(34)25-15-23(29)17-32(25)26(33)18-35-24-9-6-14-30-16-24/h3-14,16,19,23,25,27H,15,17-18H2,1-2H3,(H,31,34)/t23-,25?,27+/m1/s1 OVAPWRBQMXIPLA-JBGVBMOJSA-N 634599 US11814367, Compound 48 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634599&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349433 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccn(C)n1)c1ccccc1 InChI=1S/C27H31FN4O2/c1-18(2)19-9-11-21(12-10-19)26(20-7-5-4-6-8-20)29-27(34)24-15-22(28)17-32(24)25(33)16-23-13-14-31(3)30-23/h4-14,18,22,24,26H,15-17H2,1-3H3,(H,29,34)/t22-,24+,26+/m1/s1 QLFQARPOIHTAJO-CWDLOFLHSA-N 634600 US11814367, Compound 49 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634600&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349434 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn(C)c1)c1ccccc1 InChI=1S/C27H31FN4O2/c1-18(2)20-9-11-22(12-10-20)26(21-7-5-4-6-8-21)30-27(34)24-14-23(28)17-32(24)25(33)13-19-15-29-31(3)16-19/h4-12,15-16,18,23-24,26H,13-14,17H2,1-3H3,(H,30,34)/t23-,24+,26+/m1/s1 MFXPGXGUFMNFRC-USZFVNFHSA-N 634601 US11814367, Compound 50 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634601&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349435 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccccc1=O)c1ccccc1 InChI=1S/C28H30FN3O3/c1-19(2)20-11-13-22(14-12-20)27(21-8-4-3-5-9-21)30-28(35)24-16-23(29)17-32(24)26(34)18-31-15-7-6-10-25(31)33/h3-15,19,23-24,27H,16-18H2,1-2H3,(H,30,35)/t23-,24+,27+/m1/s1 IBSQAQOLUVATKF-DXBVXKBHSA-N 634602 US11814367, Compound 51 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634602&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349436 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1csc(C)n1)c1ccccc1 InChI=1S/C27H30FN3O2S/c1-17(2)19-9-11-21(12-10-19)26(20-7-5-4-6-8-20)30-27(33)24-13-22(28)15-31(24)25(32)14-23-16-34-18(3)29-23/h4-12,16-17,22,24,26H,13-15H2,1-3H3,(H,30,33)/t22-,24+,26+/m1/s1 ZZSHZTAVPFITTQ-CWDLOFLHSA-N 634603 US11814367, Compound 52 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634603&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349437 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccc(C)n1)c1ccccc1 InChI=1S/C27H31FN4O2/c1-18(2)20-9-11-22(12-10-20)26(21-7-5-4-6-8-21)29-27(34)24-15-23(28)16-32(24)25(33)17-31-14-13-19(3)30-31/h4-14,18,23-24,26H,15-17H2,1-3H3,(H,29,34)/t23-,24+,26+/m1/s1 FJBJHYRWJJEZKO-USZFVNFHSA-N 634606 US11814367, Compound 55 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634606&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349438 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C)cn1)c1ccccc1 InChI=1S/C27H31FN4O2/c1-18(2)20-9-11-22(12-10-20)26(21-7-5-4-6-8-21)30-27(34)24-13-23(28)16-32(24)25(33)17-31-15-19(3)14-29-31/h4-12,14-15,18,23-24,26H,13,16-17H2,1-3H3,(H,30,34)/t23-,24+,26+/m1/s1 XYISZGFWKUNAML-USZFVNFHSA-N 634607 US11814367, Compound 56 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634607&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349439 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@H]1CCC(=O)N1C)c1ccccc1 InChI=1S/C27H32FN3O3/c1-17(2)18-9-11-20(12-10-18)25(19-7-5-4-6-8-19)29-26(33)23-15-21(28)16-31(23)27(34)22-13-14-24(32)30(22)3/h4-12,17,21-23,25H,13-16H2,1-3H3,(H,29,33)/t21-,22+,23+,25+/m1/s1 QKKADBWRHDQXIH-FVEXOFTDSA-N 634608 US11814367, Compound 57 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634608&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349440 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CCC(=O)NC1)c1ccccc1 InChI=1S/C27H32FN3O3/c1-17(2)18-8-10-20(11-9-18)25(19-6-4-3-5-7-19)30-26(33)23-14-22(28)16-31(23)27(34)21-12-13-24(32)29-15-21/h3-11,17,21-23,25H,12-16H2,1-2H3,(H,29,32)(H,30,33)/t21?,22-,23+,25+/m1/s1 DMLKXNOMADJPHP-XTDMVTQSSA-N 634609 US11814367, Compound 58 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634609&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349441 CC(C)c1ccc(cc1)[C@@H](NC(=O)C1C[C@@H](F)CN1C(=O)CCc1cnccn1)c1ccccc1 InChI=1S/C28H31FN4O2/c1-19(2)20-8-10-22(11-9-20)27(21-6-4-3-5-7-21)32-28(35)25-16-23(29)18-33(25)26(34)13-12-24-17-30-14-15-31-24/h3-11,14-15,17,19,23,25,27H,12-13,16,18H2,1-2H3,(H,32,35)/t23-,25?,27+/m1/s1 YIVJMGPJRWYSDR-JBGVBMOJSA-N 634610 US11814367, Compound 59 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634610&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349442 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1cncnc1)c1ccccc1 InChI=1S/C28H31FN4O2/c1-19(2)21-9-11-23(12-10-21)27(22-6-4-3-5-7-22)32-28(35)25-14-24(29)17-33(25)26(34)13-8-20-15-30-18-31-16-20/h3-7,9-12,15-16,18-19,24-25,27H,8,13-14,17H2,1-2H3,(H,32,35)/t24-,25+,27+/m1/s1 NFQJECHLAJXESQ-OBDYRVMHSA-N 634611 US11814367, Compound 60 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634611&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349443 COc1nn(C)cc1C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(cc1)C(C)C InChI=1S/C27H31FN4O3/c1-17(2)18-10-12-20(13-11-18)24(19-8-6-5-7-9-19)29-25(33)23-14-21(28)15-32(23)27(34)22-16-31(3)30-26(22)35-4/h5-13,16-17,21,23-24H,14-15H2,1-4H3,(H,29,33)/t21-,23+,24+/m1/s1 HZUMCNPUTQDZGG-NHTMILBNSA-N 634612 US11814367, Compound 61 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634612&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349444 CC(C)c1ccc(cc1)C(NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1nnc(C)s1)c1ccccc1 InChI=1S/C27H31FN4O2S/c1-17(2)19-9-11-21(12-10-19)26(20-7-5-4-6-8-20)29-27(34)23-15-22(28)16-32(23)25(33)14-13-24-31-30-18(3)35-24/h4-12,17,22-23,26H,13-16H2,1-3H3,(H,29,34)/t22-,23+,26?/m1/s1 NLSDOGPCVUKTGE-DBRKUKIDSA-N 634613 US11814367, Compound 62 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634613&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349445 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cc(F)ccc1Cl)c1ccccc1 InChI=1S/C29H29ClF2N2O2/c1-18(2)19-8-10-21(11-9-19)28(20-6-4-3-5-7-20)33-29(36)26-16-24(32)17-34(26)27(35)15-22-14-23(31)12-13-25(22)30/h3-14,18,24,26,28H,15-17H2,1-2H3,(H,33,36)/t24-,26+,28+/m1/s1 MUHKAOCEPMWHHT-XDIPAPSNSA-N 634614 US11814367, Compound 63 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634614&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349446 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)c1ccccn1)c1ccccc1 InChI=1S/C29H32FN3O2/c1-19(2)21-12-14-23(15-13-21)27(22-9-5-4-6-10-22)32-28(34)26-17-24(30)18-33(26)29(35)20(3)25-11-7-8-16-31-25/h4-16,19-20,24,26-27H,17-18H2,1-3H3,(H,32,34)/t20?,24-,26+,27+/m1/s1 SMDAMOXYWJTTJD-WKBUYWNLSA-N 634615 US11814367, Compound 64 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634615&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349447 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1ccccn1)c1ccccc1 InChI=1S/C29H32FN3O2/c1-20(2)21-11-13-23(14-12-21)28(22-8-4-3-5-9-22)32-29(35)26-18-24(30)19-33(26)27(34)16-15-25-10-6-7-17-31-25/h3-14,17,20,24,26,28H,15-16,18-19H2,1-2H3,(H,32,35)/t24-,26+,28+/m1/s1 KMMZZMYHAJSDEC-XDIPAPSNSA-N 634616 US11814367, Compound 65 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634616&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349448 CC(C)C(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(cc1)C(C)C InChI=1S/C27H34FN3O3/c1-17(2)19-10-12-21(13-11-19)25(20-8-6-5-7-9-20)30-27(34)23-14-22(28)16-31(23)24(32)15-29-26(33)18(3)4/h5-13,17-18,22-23,25H,14-16H2,1-4H3,(H,29,33)(H,30,34)/t22-,23+,25+/m1/s1 NOTXJVGVOBKDOR-CUYJMHBOSA-N 634618 US11814367, Compound 67 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634618&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349449 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nnc2ccccc12)c1ccccc1 InChI=1S/C29H30FN5O2/c1-19(2)20-12-14-22(15-13-20)28(21-8-4-3-5-9-21)31-29(37)26-16-23(30)17-34(26)27(36)18-35-25-11-7-6-10-24(25)32-33-35/h3-15,19,23,26,28H,16-18H2,1-2H3,(H,31,37)/t23-,26+,28+/m1/s1 BARKAFAMFDCENP-KHGZIGHDSA-N 634619 US11814367, Compound 68 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634619&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349450 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nc(C)sc1C)c1ccccc1 InChI=1S/C28H32FN3O2S/c1-17(2)20-10-12-22(13-11-20)27(21-8-6-5-7-9-21)31-28(34)25-14-23(29)16-32(25)26(33)15-24-18(3)35-19(4)30-24/h5-13,17,23,25,27H,14-16H2,1-4H3,(H,31,34)/t23-,25+,27+/m1/s1 UJTCHFOAMVQYHD-NIYJGHKDSA-N 634620 US11814367, Compound 69 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634620&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349451 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c(C)noc1C)c1ccccc1 InChI=1S/C28H32FN3O3/c1-17(2)20-10-12-22(13-11-20)27(21-8-6-5-7-9-21)30-28(34)25-14-23(29)16-32(25)26(33)15-24-18(3)31-35-19(24)4/h5-13,17,23,25,27H,14-16H2,1-4H3,(H,30,34)/t23-,25+,27+/m1/s1 WPQKKTUZNDFAGC-NIYJGHKDSA-N 634621 US11814367, Compound 70 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634621&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349452 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)n1ccccc1=O)c1ccccc1 InChI=1S/C29H32FN3O3/c1-19(2)21-12-14-23(15-13-21)27(22-9-5-4-6-10-22)31-28(35)25-17-24(30)18-33(25)29(36)20(3)32-16-8-7-11-26(32)34/h4-16,19-20,24-25,27H,17-18H2,1-3H3,(H,31,35)/t20?,24-,25+,27+/m1/s1 OKBYMNDGNPDZKW-JTJYHYRWSA-N 634624 US11814367, Compound 73 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634624&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349453 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCCn1ccnc1)c1ccccc1 InChI=1S/C28H33FN4O2/c1-20(2)21-10-12-23(13-11-21)27(22-7-4-3-5-8-22)31-28(35)25-17-24(29)18-33(25)26(34)9-6-15-32-16-14-30-19-32/h3-5,7-8,10-14,16,19-20,24-25,27H,6,9,15,17-18H2,1-2H3,(H,31,35)/t24-,25+,27+/m1/s1 CMLIHXPGFMCDLQ-OBDYRVMHSA-N 634626 US11814367, Compound 75 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634626&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349454 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1cnn(C)c1)c1ccccc1 InChI=1S/C28H33FN4O2/c1-19(2)21-10-12-23(13-11-21)27(22-7-5-4-6-8-22)31-28(35)25-15-24(29)18-33(25)26(34)14-9-20-16-30-32(3)17-20/h4-8,10-13,16-17,19,24-25,27H,9,14-15,18H2,1-3H3,(H,31,35)/t24-,25+,27+/m1/s1 NHQYFROPLKAFGS-OBDYRVMHSA-N 634627 US11814367, Compound 76 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634627&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349455 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnc2ccccc12)c1ccccc1 InChI=1S/C30H31FN4O2/c1-20(2)21-12-14-23(15-13-21)29(22-8-4-3-5-9-22)33-30(37)27-16-24(31)17-35(27)28(36)18-34-19-32-25-10-6-7-11-26(25)34/h3-15,19-20,24,27,29H,16-18H2,1-2H3,(H,33,37)/t24-,27+,29+/m1/s1 BXFGSGIRRVUNBG-QXGAZULMSA-N 634628 US11814367, Compound 77 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634628&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349456 COc1cccc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cc2)C(C)C)n1 InChI=1S/C29H32FN3O3/c1-19(2)20-12-14-22(15-13-20)28(21-8-5-4-6-9-21)32-29(35)25-16-23(30)18-33(25)27(34)17-24-10-7-11-26(31-24)36-3/h4-15,19,23,25,28H,16-18H2,1-3H3,(H,32,35)/t23-,25+,28+/m1/s1 HHRLMASLZUNRKR-CRRLPVGBSA-N 634632 US11814367, Compound 81 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634632&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349457 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cc(C)n(C)n1)c1ccccc1 InChI=1S/C28H33FN4O2/c1-18(2)20-10-12-22(13-11-20)27(21-8-6-5-7-9-21)30-28(35)25-15-23(29)17-33(25)26(34)16-24-14-19(3)32(4)31-24/h5-14,18,23,25,27H,15-17H2,1-4H3,(H,30,35)/t23-,25+,27+/m1/s1 ZOZJAWPISAYAKB-NIYJGHKDSA-N 634634 US11814367, Compound 83 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634634&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349458 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c(C)n[nH]c1C)c1ccccc1 634635 US11814367, Compound 84 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634635&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349459 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CCCCC1=O)c1ccccc1 InChI=1S/C28H34FN3O3/c1-19(2)20-11-13-22(14-12-20)27(21-8-4-3-5-9-21)30-28(35)24-16-23(29)17-32(24)26(34)18-31-15-7-6-10-25(31)33/h3-5,8-9,11-14,19,23-24,27H,6-7,10,15-18H2,1-2H3,(H,30,35)/t23-,24+,27+/m1/s1 FBBUQMYZXRTKIB-DXBVXKBHSA-N 634636 US11814367, Compound 85 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634636&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349460 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c[nH]c2ccccc12)c1ccccc1 634637 US11814367, Compound 86 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634637&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349461 CC(C)c1nc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cc2)C(C)C)no1 InChI=1S/C28H33FN4O3/c1-17(2)19-10-12-21(13-11-19)26(20-8-6-5-7-9-20)31-27(35)23-14-22(29)16-33(23)25(34)15-24-30-28(18(3)4)36-32-24/h5-13,17-18,22-23,26H,14-16H2,1-4H3,(H,31,35)/t22-,23+,26+/m1/s1 LTFPEQSVNCXCKA-UMFSSWHCSA-N 634638 US11814367, Compound 87 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634638&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349462 COc1ccc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cc2)C(C)C)cc1 InChI=1S/C30H33FN2O3/c1-20(2)22-11-13-24(14-12-22)29(23-7-5-4-6-8-23)32-30(35)27-18-25(31)19-33(27)28(34)17-21-9-15-26(36-3)16-10-21/h4-16,20,25,27,29H,17-19H2,1-3H3,(H,32,35)/t25-,27+,29+/m1/s1 BMJFAHNFPFFTCZ-WBJKNQCFSA-N 634639 US11814367, Compound 88 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634639&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349463 COc1ccc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cc2)C(C)C)cc1F InChI=1S/C30H32F2N2O3/c1-19(2)21-10-12-23(13-11-21)29(22-7-5-4-6-8-22)33-30(36)26-17-24(31)18-34(26)28(35)16-20-9-14-27(37-3)25(32)15-20/h4-15,19,24,26,29H,16-18H2,1-3H3,(H,33,36)/t24-,26+,29+/m1/s1 VBBUPVNWDXJRSV-AZIXZEHSSA-N 634640 US11814367, Compound 89 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634640&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349464 COc1ccc(F)cc1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(cc1)C(C)C InChI=1S/C30H32F2N2O3/c1-19(2)20-9-11-22(12-10-20)29(21-7-5-4-6-8-21)33-30(36)26-17-25(32)18-34(26)28(35)16-23-15-24(31)13-14-27(23)37-3/h4-15,19,25-26,29H,16-18H2,1-3H3,(H,33,36)/t25-,26+,29+/m1/s1 NGZRFNGNWMRTDV-ALTZYDRJSA-N 634641 US11814367, Compound 90 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634641&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349465 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)COc1ccccc1C)c1ccccc1 InChI=1S/C30H33FN2O3/c1-20(2)22-13-15-24(16-14-22)29(23-10-5-4-6-11-23)32-30(35)26-17-25(31)18-33(26)28(34)19-36-27-12-8-7-9-21(27)3/h4-16,20,25-26,29H,17-19H2,1-3H3,(H,32,35)/t25-,26+,29+/m1/s1 QZCSKNLCNVCUDE-ALTZYDRJSA-N 634642 US11814367, Compound 91 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634642&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349466 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CCNC(=O)C1)c1ccccc1 InChI=1S/C27H32FN3O3/c1-17(2)18-8-10-20(11-9-18)25(19-6-4-3-5-7-19)30-26(33)23-15-22(28)16-31(23)27(34)21-12-13-29-24(32)14-21/h3-11,17,21-23,25H,12-16H2,1-2H3,(H,29,32)(H,30,33)/t21?,22-,23+,25+/m1/s1 IXMAFESUPIRNDS-XTDMVTQSSA-N 634644 US11814367, Compound 93 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634644&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349467 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCCc1cccnc1)c1ccccc1 InChI=1S/C30H34FN3O2/c1-21(2)23-13-15-25(16-14-23)29(24-10-4-3-5-11-24)33-30(36)27-18-26(31)20-34(27)28(35)12-6-8-22-9-7-17-32-19-22/h3-5,7,9-11,13-17,19,21,26-27,29H,6,8,12,18,20H2,1-2H3,(H,33,36)/t26-,27+,29+/m1/s1 YITYAVKKWDRJRZ-XQFUHLNNSA-N 634645 US11814367, Compound 94 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634645&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349468 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCCc1ccncc1)c1ccccc1 InChI=1S/C30H34FN3O2/c1-21(2)23-11-13-25(14-12-23)29(24-8-4-3-5-9-24)33-30(36)27-19-26(31)20-34(27)28(35)10-6-7-22-15-17-32-18-16-22/h3-5,8-9,11-18,21,26-27,29H,6-7,10,19-20H2,1-2H3,(H,33,36)/t26-,27+,29+/m1/s1 XWPNBBUYZSGETE-XQFUHLNNSA-N 634646 US11814367, Compound 95 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634646&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349469 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccc2ncccc2c1)c1ccccc1 InChI=1S/C32H32FN3O2/c1-21(2)23-11-13-25(14-12-23)31(24-7-4-3-5-8-24)35-32(38)29-19-27(33)20-36(29)30(37)18-22-10-15-28-26(17-22)9-6-16-34-28/h3-17,21,27,29,31H,18-20H2,1-2H3,(H,35,38)/t27-,29+,31+/m1/s1 WCQCEMYRAVDUNX-QKMMQOFESA-N 634647 US11814367, Compound 96 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634647&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349470 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)Cc1ccncc1)c1ccccc1 InChI=1S/C30H34FN3O2/c1-20(2)23-9-11-25(12-10-23)28(24-7-5-4-6-8-24)33-29(35)27-18-26(31)19-34(27)30(36)21(3)17-22-13-15-32-16-14-22/h4-16,20-21,26-28H,17-19H2,1-3H3,(H,33,35)/t21?,26-,27+,28+/m1/s1 MOGZOAAWYALSFT-CWCMMENHSA-N 634649 US11814367, Compound 98 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634649&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349471 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1ccnc(C)c1)c1ccccc1 InChI=1S/C30H34FN3O2/c1-20(2)23-10-12-25(13-11-23)29(24-7-5-4-6-8-24)33-30(36)27-18-26(31)19-34(27)28(35)14-9-22-15-16-32-21(3)17-22/h4-8,10-13,15-17,20,26-27,29H,9,14,18-19H2,1-3H3,(H,33,36)/t26-,27+,29+/m1/s1 MOLNJHXZTUFKQH-XQFUHLNNSA-N 634650 US11814367, Compound 99 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634650&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349472 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1ccc(C)nc1)c1ccccc1 InChI=1S/C30H34FN3O2/c1-20(2)23-12-14-25(15-13-23)29(24-7-5-4-6-8-24)33-30(36)27-17-26(31)19-34(27)28(35)16-11-22-10-9-21(3)32-18-22/h4-10,12-15,18,20,26-27,29H,11,16-17,19H2,1-3H3,(H,33,36)/t26-,27+,29+/m1/s1 SDDBXONUCFLNAK-XQFUHLNNSA-N 634651 US11814367, Compound 100 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634651&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349473 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1ccc(C)cn1)c1ccccc1 InChI=1S/C30H34FN3O2/c1-20(2)22-10-12-24(13-11-22)29(23-7-5-4-6-8-23)33-30(36)27-17-25(31)19-34(27)28(35)16-15-26-14-9-21(3)18-32-26/h4-14,18,20,25,27,29H,15-17,19H2,1-3H3,(H,33,36)/t25-,27+,29+/m1/s1 UHWYNHBVSUQSRZ-WBJKNQCFSA-N 634652 US11814367, Compound 101 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634652&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349474 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1cccnc1C)c1ccccc1 InChI=1S/C30H34FN3O2/c1-20(2)22-11-13-25(14-12-22)29(24-8-5-4-6-9-24)33-30(36)27-18-26(31)19-34(27)28(35)16-15-23-10-7-17-32-21(23)3/h4-14,17,20,26-27,29H,15-16,18-19H2,1-3H3,(H,33,36)/t26-,27+,29+/m1/s1 XQAXRKBMMPHLHQ-XQFUHLNNSA-N 634653 US11814367, Compound 102 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634653&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349475 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1c(C)noc1C)c1ccccc1 InChI=1S/C29H34FN3O3/c1-18(2)21-10-12-23(13-11-21)28(22-8-6-5-7-9-22)31-29(35)26-16-24(30)17-33(26)27(34)15-14-25-19(3)32-36-20(25)4/h5-13,18,24,26,28H,14-17H2,1-4H3,(H,31,35)/t24-,26+,28+/m1/s1 GKNIXSYBBFCZSO-XDIPAPSNSA-N 634654 US11814367, Compound 103 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634654&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349476 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1c[nH]c2ncccc12)c1ccccc1 634655 US11814367, Compound 104 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634655&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349477 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCCn1ccnc1C)c1ccccc1 InChI=1S/C29H35FN4O2/c1-20(2)22-11-13-24(14-12-22)28(23-8-5-4-6-9-23)32-29(36)26-18-25(30)19-34(26)27(35)10-7-16-33-17-15-31-21(33)3/h4-6,8-9,11-15,17,20,25-26,28H,7,10,16,18-19H2,1-3H3,(H,32,36)/t25-,26+,28+/m1/s1 MWHNGJVHLHTYBT-PBWSGDRGSA-N 634656 US11814367, Compound 105 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634656&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349478 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCn1nc(C)cc1C)c1ccccc1 InChI=1S/C29H35FN4O2/c1-19(2)22-10-12-24(13-11-22)28(23-8-6-5-7-9-23)31-29(36)26-17-25(30)18-33(26)27(35)14-15-34-21(4)16-20(3)32-34/h5-13,16,19,25-26,28H,14-15,17-18H2,1-4H3,(H,31,36)/t25-,26+,28+/m1/s1 CSRRIUHUWHZXHD-PBWSGDRGSA-N 634657 US11814367, Compound 106 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634657&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349479 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccc(NC(C)=O)cc1)c1ccccc1 InChI=1S/C31H34FN3O3/c1-20(2)23-11-13-25(14-12-23)30(24-7-5-4-6-8-24)34-31(38)28-18-26(32)19-35(28)29(37)17-22-9-15-27(16-10-22)33-21(3)36/h4-16,20,26,28,30H,17-19H2,1-3H3,(H,33,36)(H,34,38)/t26-,28+,30+/m1/s1 XPRUOSIGCCDVLQ-BOACMQGQSA-N 634658 US11814367, Compound 107 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634658&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349480 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCC(=O)N1CCCC1)c1ccccc1 InChI=1S/C29H36FN3O3/c1-20(2)21-10-12-23(13-11-21)28(22-8-4-3-5-9-22)31-29(36)25-18-24(30)19-33(25)27(35)15-14-26(34)32-16-6-7-17-32/h3-5,8-13,20,24-25,28H,6-7,14-19H2,1-2H3,(H,31,36)/t24-,25+,28+/m1/s1 MVTFVZJJDGUBKA-QQNWGBJXSA-N 634659 US11814367, Compound 108 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634659&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349481 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1c[nH]c2ccccc12)c1ccccc1 634660 US11814367, Compound 109 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634660&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349482 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1ccc(C)nc1C)c1ccccc1 InChI=1S/C31H36FN3O2/c1-20(2)23-12-14-26(15-13-23)30(25-8-6-5-7-9-25)34-31(37)28-18-27(32)19-35(28)29(36)17-16-24-11-10-21(3)33-22(24)4/h5-15,20,27-28,30H,16-19H2,1-4H3,(H,34,37)/t27-,28+,30+/m1/s1 QKCHLKVYQRPIPJ-UNRZKBSHSA-N 634661 US11814367, Compound 110 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634661&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349483 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1ccc(=O)[nH]n1)c1ccccc1 634665 US11814367, Compound 114 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634665&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349484 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1C(=O)CNC1=O)c1ccccc1 InChI=1S/C26H29FN4O4/c1-16(2)17-8-10-19(11-9-17)24(18-6-4-3-5-7-18)29-25(34)21-12-20(27)14-30(21)23(33)15-31-22(32)13-28-26(31)35/h3-11,16,20-21,24H,12-15H2,1-2H3,(H,28,35)(H,29,34)/t20-,21+,24+/m1/s1 AXYGWIGHTBIEQS-DPLHUUCSSA-N 634668 US11814367, Compound 117 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634668&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349485 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccc2ncnn2c1)c1ccccc1 InChI=1S/C29H30FN5O2/c1-19(2)21-9-11-23(12-10-21)28(22-6-4-3-5-7-22)33-29(37)25-15-24(30)17-34(25)27(36)14-20-8-13-26-31-18-32-35(26)16-20/h3-13,16,18-19,24-25,28H,14-15,17H2,1-2H3,(H,33,37)/t24-,25+,28+/m1/s1 BNCNXHWDPGEHLJ-QQNWGBJXSA-N 634669 US11814367, Compound 118 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634669&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349486 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1noc2ccccc12)c1ccccc1 InChI=1S/C30H30FN3O3/c1-19(2)20-12-14-22(15-13-20)29(21-8-4-3-5-9-21)32-30(36)26-16-23(31)18-34(26)28(35)17-25-24-10-6-7-11-27(24)37-33-25/h3-15,19,23,26,29H,16-18H2,1-2H3,(H,32,36)/t23-,26+,29+/m1/s1 SCXYZBWWCUQLPQ-IXLXJOPFSA-N 634670 US11814367, Compound 119 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634670&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349487 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnc2ccccn12)c1ccccc1 InChI=1S/C30H31FN4O2/c1-20(2)21-11-13-23(14-12-21)29(22-8-4-3-5-9-22)33-30(37)26-16-24(31)19-35(26)28(36)17-25-18-32-27-10-6-7-15-34(25)27/h3-15,18,20,24,26,29H,16-17,19H2,1-2H3,(H,33,37)/t24-,26+,29+/m1/s1 KYUAMACYAUWNKY-AZIXZEHSSA-N 634672 US11814367, Compound 121 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634672&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349488 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C)cc1C)c1ccccc1 InChI=1S/C28H33FN4O2/c1-18(2)21-10-12-23(13-11-21)27(22-8-6-5-7-9-22)30-28(35)25-15-24(29)16-32(25)26(34)17-33-20(4)14-19(3)31-33/h5-14,18,24-25,27H,15-17H2,1-4H3,(H,30,35)/t24-,25+,27+/m1/s1 ZOMGIRPRYBVDBM-OBDYRVMHSA-N 634676 US11814367, Compound 125 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634676&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349489 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C)c(=O)[nH]c1=O)c1ccccc1 634677 US11814367, Compound 126 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634677&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349490 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccc2c(F)cccc12)c1ccccc1 InChI=1S/C31H31F2N3O2/c1-20(2)21-11-13-23(14-12-21)30(22-7-4-3-5-8-22)34-31(38)28-17-24(32)18-36(28)29(37)19-35-16-15-25-26(33)9-6-10-27(25)35/h3-16,20,24,28,30H,17-19H2,1-2H3,(H,34,38)/t24-,28+,30+/m1/s1 KWMXBHVFKVUVFS-HZXVKSMZSA-N 634679 US11814367, Compound 128 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634679&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349491 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CS(=O)(=O)N1CCCC1)c1ccccc1 InChI=1S/C27H34FN3O4S/c1-19(2)20-10-12-22(13-11-20)26(21-8-4-3-5-9-21)29-27(33)24-16-23(28)17-31(24)25(32)18-36(34,35)30-14-6-7-15-30/h3-5,8-13,19,23-24,26H,6-7,14-18H2,1-2H3,(H,29,33)/t23-,24+,26+/m1/s1 OZEGBYVLTQQRBW-USZFVNFHSA-N 634680 US11814367, Compound 129 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634680&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349492 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cccc2ncccc12)c1ccccc1 InChI=1S/C32H32FN3O2/c1-21(2)22-13-15-24(16-14-22)31(23-8-4-3-5-9-23)35-32(38)29-19-26(33)20-36(29)30(37)18-25-10-6-12-28-27(25)11-7-17-34-28/h3-17,21,26,29,31H,18-20H2,1-2H3,(H,35,38)/t26-,29+,31+/m1/s1 LARIXPBHQOKWOH-ZVAUBVARSA-N 634681 US11814367, Compound 130 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634681&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349493 COc1ccc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cc2)C(C)C)c(c1)C#N InChI=1S/C31H32FN3O3/c1-20(2)21-9-11-23(12-10-21)30(22-7-5-4-6-8-22)34-31(37)28-17-26(32)19-35(28)29(36)16-24-13-14-27(38-3)15-25(24)18-33/h4-15,20,26,28,30H,16-17,19H2,1-3H3,(H,34,37)/t26-,28+,30+/m1/s1 INWUSGJFKNWLLL-BOACMQGQSA-N 634684 US11814367, Compound 133 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634684&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349494 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1cnc2[nH]ccc2c1)c1ccccc1 634685 US11814367, Compound 134 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634685&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349495 COc1cccnc1CCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(cc1)C(C)C InChI=1S/C30H34FN3O3/c1-20(2)21-11-13-23(14-12-21)29(22-8-5-4-6-9-22)33-30(36)26-18-24(31)19-34(26)28(35)16-15-25-27(37-3)10-7-17-32-25/h4-14,17,20,24,26,29H,15-16,18-19H2,1-3H3,(H,33,36)/t24-,26+,29+/m1/s1 ZETFHAKCROKWOO-AZIXZEHSSA-N 634686 US11814367, Compound 135 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634686&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349496 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c(C)nn(C)c1C)c1ccccc1 InChI=1S/C29H35FN4O2/c1-18(2)21-11-13-23(14-12-21)28(22-9-7-6-8-10-22)31-29(36)26-15-24(30)17-34(26)27(35)16-25-19(3)32-33(5)20(25)4/h6-14,18,24,26,28H,15-17H2,1-5H3,(H,31,36)/t24-,26+,28+/m1/s1 UUSXQDFMCQPADQ-XDIPAPSNSA-N 634687 US11814367, Compound 136 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634687&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349497 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cc2ccccc2n1C)c1ccccc1 InChI=1S/C32H34FN3O2/c1-21(2)22-13-15-24(16-14-22)31(23-9-5-4-6-10-23)34-32(38)29-18-26(33)20-36(29)30(37)19-27-17-25-11-7-8-12-28(25)35(27)3/h4-17,21,26,29,31H,18-20H2,1-3H3,(H,34,38)/t26-,29+,31+/m1/s1 ODTYENZTJWEUPK-ZVAUBVARSA-N 634688 US11814367, Compound 137 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634688&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349498 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c[nH]c2ccc(C)cc12)c1ccccc1 634689 US11814367, Compound 138 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634689&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349499 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@H]1CCN([C@H]1c1cccnc1)C(C)=O)c1ccccc1 InChI=1S/C33H37FN4O3/c1-21(2)23-11-13-25(14-12-23)30(24-8-5-4-6-9-24)36-32(40)29-18-27(34)20-38(29)33(41)28-15-17-37(22(3)39)31(28)26-10-7-16-35-19-26/h4-14,16,19,21,27-31H,15,17-18,20H2,1-3H3,(H,36,40)/t27-,28-,29+,30+,31+/m1/s1 MLUIQZMIHDSTLG-YOGXEWEVSA-N 634691 US11814367, Compound 140 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634691&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349500 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CN(CCO1)C(C)=O)c1ccccc1 InChI=1S/C28H34FN3O4/c1-18(2)20-9-11-22(12-10-20)26(21-7-5-4-6-8-21)30-27(34)24-15-23(29)16-32(24)28(35)25-17-31(19(3)33)13-14-36-25/h4-12,18,23-26H,13-17H2,1-3H3,(H,30,34)/t23-,24+,25?,26+/m1/s1 CIWKTPUOQQDMDL-NNQWSVJYSA-N 634692 US11814367, Compound 141 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634692&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349501 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN(C)C(C)=O)c1ccccc1 InChI=1S/C26H32FN3O3/c1-17(2)19-10-12-21(13-11-19)25(20-8-6-5-7-9-20)28-26(33)23-14-22(27)15-30(23)24(32)16-29(4)18(3)31/h5-13,17,22-23,25H,14-16H2,1-4H3,(H,28,33)/t22-,23+,25+/m1/s1 KOMVCGXOYJRQNN-CUYJMHBOSA-N 634693 US11814367, Compound 142 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634693&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349502 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CCN(CC1)C(C)=O)c1ccccc1 InChI=1S/C29H36FN3O3/c1-19(2)21-9-11-23(12-10-21)27(22-7-5-4-6-8-22)31-28(35)26-17-25(30)18-33(26)29(36)24-13-15-32(16-14-24)20(3)34/h4-12,19,24-27H,13-18H2,1-3H3,(H,31,35)/t25-,26+,27+/m1/s1 UBDMIQKFWZPTQT-PVHODMMVSA-N 634695 US11814367, Compound 144 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634695&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349503 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1(C)CN(C1)C(C)=O)c1ccccc1 InChI=1S/C28H34FN3O3/c1-18(2)20-10-12-22(13-11-20)25(21-8-6-5-7-9-21)30-26(34)24-14-23(29)15-32(24)27(35)28(4)16-31(17-28)19(3)33/h5-13,18,23-25H,14-17H2,1-4H3,(H,30,34)/t23-,24+,25+/m1/s1 GDALLZUHJUOMNR-DSITVLBTSA-N 634697 US11814367, Compound 146 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634697&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349504 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CCN(C1)C(C)=O)c1ccccc1 InChI=1S/C28H34FN3O3/c1-18(2)20-9-11-22(12-10-20)26(21-7-5-4-6-8-21)30-27(34)25-15-24(29)17-32(25)28(35)23-13-14-31(16-23)19(3)33/h4-12,18,23-26H,13-17H2,1-3H3,(H,30,34)/t23?,24-,25+,26+/m1/s1 IJOPRJWSKJLBBJ-CSQIJOFWSA-N 634698 US11814367, Compound 147 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634698&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349505 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1=NOC2(CN(C2)C(C)=O)C1)c1ccccc1 InChI=1S/C29H33FN4O4/c1-18(2)20-9-11-22(12-10-20)26(21-7-5-4-6-8-21)31-27(36)25-13-23(30)15-34(25)28(37)24-14-29(38-32-24)16-33(17-29)19(3)35/h4-12,18,23,25-26H,13-17H2,1-3H3,(H,31,36)/t23-,25+,26+/m1/s1 RSNUOZBGJGLORU-AFESJLNVSA-N 634702 US11814367, Compound 151 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634702&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349506 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CC1(C)CN(C1)C(C)=O)c1ccccc1 InChI=1S/C29H36FN3O3/c1-19(2)21-10-12-23(13-11-21)27(22-8-6-5-7-9-22)31-28(36)25-14-24(30)16-33(25)26(35)15-29(4)17-32(18-29)20(3)34/h5-13,19,24-25,27H,14-18H2,1-4H3,(H,31,36)/t24-,25+,27+/m1/s1 MEPIGSQMRGQFSH-OBDYRVMHSA-N 634705 US11814367, Compound 154 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634705 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634705&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349507 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C[C@H]1CCCC1C(C)=O)c1ccccc1 InChI=1S/C30H37FN2O3/c1-19(2)21-12-14-23(15-13-21)29(22-8-5-4-6-9-22)32-30(36)27-17-25(31)18-33(27)28(35)16-24-10-7-11-26(24)20(3)34/h4-6,8-9,12-15,19,24-27,29H,7,10-11,16-18H2,1-3H3,(H,32,36)/t24-,25-,26?,27+,29+/m1/s1 YXDBNVXBWQDAJM-RAQDTNGZSA-N 634706 US11814367, Compound 155 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634706&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349508 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@H]1CN(CCCO1)C(C)=O)c1ccccc1 InChI=1S/C29H36FN3O4/c1-19(2)21-10-12-23(13-11-21)27(22-8-5-4-6-9-22)31-28(35)25-16-24(30)17-33(25)29(36)26-18-32(20(3)34)14-7-15-37-26/h4-6,8-13,19,24-27H,7,14-18H2,1-3H3,(H,31,35)/t24-,25+,26-,27+/m1/s1 FTBJGLZQCZSVRN-RAVGUYNFSA-N 634709 US11814367, Compound 158 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634709&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349509 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CCN(CC1=O)C(C)=O)c1ccccc1 InChI=1S/C29H35FN4O4/c1-19(2)21-9-11-23(12-10-21)28(22-7-5-4-6-8-22)31-29(38)25-15-24(30)16-34(25)27(37)18-33-14-13-32(20(3)35)17-26(33)36/h4-12,19,24-25,28H,13-18H2,1-3H3,(H,31,38)/t24-,25+,28+/m1/s1 JRGYBRACIUHUEE-QQNWGBJXSA-N 634711 US11814367, Compound 160 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634711&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349510 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@H]1C[C@@H]2CN(C[C@@H]2O1)C(C)=O)c1ccccc1 InChI=1S/C30H36FN3O4/c1-18(2)20-9-11-22(12-10-20)28(21-7-5-4-6-8-21)32-29(36)25-14-24(31)16-34(25)30(37)26-13-23-15-33(19(3)35)17-27(23)38-26/h4-12,18,23-28H,13-17H2,1-3H3,(H,32,36)/t23-,24-,25+,26-,27+,28+/m1/s1 YLPRWAUNZBZGIS-PZIBSJIKSA-N 634713 US11814367, Compound 162 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634713&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349511 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CCC2(CN(C2)C(C)=O)O1)c1ccccc1 InChI=1S/C30H36FN3O4/c1-19(2)21-9-11-23(12-10-21)27(22-7-5-4-6-8-22)32-28(36)25-15-24(31)16-34(25)29(37)26-13-14-30(38-26)17-33(18-30)20(3)35/h4-12,19,24-27H,13-18H2,1-3H3,(H,32,36)/t24-,25+,26?,27+/m1/s1 HMCNTSFOASBSRH-ZSELOXDISA-N 634714 US11814367, Compound 163 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634714&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349512 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@H]1CN([C@@H]2CCO[C@H]12)C(C)=O)c1ccccc1 InChI=1S/C30H36FN3O4/c1-18(2)20-9-11-22(12-10-20)27(21-7-5-4-6-8-21)32-29(36)26-15-23(31)16-34(26)30(37)24-17-33(19(3)35)25-13-14-38-28(24)25/h4-12,18,23-28H,13-17H2,1-3H3,(H,32,36)/t23-,24+,25-,26+,27+,28-/m1/s1 NPYYUZRPJLZHJW-XZTPWNLHSA-N 634717 US11814367, Compound 166 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634717&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349513 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1Cc2nccnc2CN1C(C)=O)c1ccccc1 InChI=1S/C31H34FN5O3/c1-19(2)21-9-11-23(12-10-21)29(22-7-5-4-6-8-22)35-30(39)27-15-24(32)17-37(27)31(40)28-16-25-26(34-14-13-33-25)18-36(28)20(3)38/h4-14,19,24,27-29H,15-18H2,1-3H3,(H,35,39)/t24-,27+,28?,29+/m1/s1 DKHRCRCLJICHOR-HTNHSPBJSA-N 634718 US11814367, Compound 167 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634718&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349514 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CCCN(CC1)C(C)=O)c1ccccc1 InChI=1S/C30H38FN3O3/c1-20(2)22-11-13-24(14-12-22)28(23-8-5-4-6-9-23)32-29(36)27-18-26(31)19-34(27)30(37)25-10-7-16-33(17-15-25)21(3)35/h4-6,8-9,11-14,20,25-28H,7,10,15-19H2,1-3H3,(H,32,36)/t25?,26-,27+,28+/m1/s1 BVSSSXSIFQAVJI-LEAHPRTDSA-N 634720 US11814367, Compound 169 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634720&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349515 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C[C@@H]1CCCN(C1)C(C)=O)c1ccccc1 InChI=1S/C30H38FN3O3/c1-20(2)23-11-13-25(14-12-23)29(24-9-5-4-6-10-24)32-30(37)27-17-26(31)19-34(27)28(36)16-22-8-7-15-33(18-22)21(3)35/h4-6,9-14,20,22,26-27,29H,7-8,15-19H2,1-3H3,(H,32,37)/t22-,26+,27-,29-/m0/s1 VEKIZDAOROQPMI-IPRRSYPOSA-N 634722 US11814367, Compound 171 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634722&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349516 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCC1CCCN1C(C)=O)c1ccccc1 InChI=1S/C30H38FN3O3/c1-20(2)22-11-13-24(14-12-22)29(23-8-5-4-6-9-23)32-30(37)27-18-25(31)19-34(27)28(36)16-15-26-10-7-17-33(26)21(3)35/h4-6,8-9,11-14,20,25-27,29H,7,10,15-19H2,1-3H3,(H,32,37)/t25-,26?,27+,29+/m1/s1 LHPQAMHCCQXWSP-KFYVJBMYSA-N 634723 US11814367, Compound 172 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634723&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349517 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CC11CCN(CC1)C(C)=O)c1ccccc1 InChI=1S/C31H38FN3O3/c1-20(2)22-9-11-24(12-10-22)28(23-7-5-4-6-8-23)33-29(37)27-17-25(32)19-35(27)30(38)26-18-31(26)13-15-34(16-14-31)21(3)36/h4-12,20,25-28H,13-19H2,1-3H3,(H,33,37)/t25-,26?,27+,28+/m1/s1 OCXSFSUWZLWDEF-LBSFNXSNSA-N 634725 US11814367, Compound 174 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634725&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349518 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CCCN(C1C)C(C)=O)c1ccccc1 InChI=1S/C30H38FN3O3/c1-19(2)22-12-14-24(15-13-22)28(23-9-6-5-7-10-23)32-29(36)27-17-25(31)18-34(27)30(37)26-11-8-16-33(20(26)3)21(4)35/h5-7,9-10,12-15,19-20,25-28H,8,11,16-18H2,1-4H3,(H,32,36)/t20?,25-,26?,27+,28+/m1/s1 BAAMCEAYPUKDST-DYSHZBFDSA-N 634729 US11814367, Compound 178 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634729&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349519 CC[C@@H]1CN(C[C@@H]1C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(cc1)C(C)C)C(C)=O InChI=1S/C30H38FN3O3/c1-5-21-16-33(20(4)35)18-26(21)30(37)34-17-25(31)15-27(34)29(36)32-28(23-9-7-6-8-10-23)24-13-11-22(12-14-24)19(2)3/h6-14,19,21,25-28H,5,15-18H2,1-4H3,(H,32,36)/t21-,25-,26+,27+,28+/m1/s1 PXNUEWFHAMKACL-NUIVWNOOSA-N 634730 US11814367, Compound 179 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634730&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349520 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)C1CCN(CC1)C(C)=O)c1ccccc1 InChI=1S/C31H40FN3O3/c1-20(2)23-10-12-26(13-11-23)29(25-8-6-5-7-9-25)33-30(37)28-18-27(32)19-35(28)31(38)21(3)24-14-16-34(17-15-24)22(4)36/h5-13,20-21,24,27-29H,14-19H2,1-4H3,(H,33,37)/t21?,27-,28+,29+/m1/s1 RINYYBUUGFTJCM-KMHIBMORSA-N 634731 US11814367, Compound 180 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634731&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349521 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@H]1CCC[C@@H]2CN(C[C@H]12)C(C)=O)c1ccccc1 InChI=1S/C32H40FN3O3/c1-20(2)22-12-14-24(15-13-22)30(23-8-5-4-6-9-23)34-31(38)29-16-26(33)18-36(29)32(39)27-11-7-10-25-17-35(21(3)37)19-28(25)27/h4-6,8-9,12-15,20,25-30H,7,10-11,16-19H2,1-3H3,(H,34,38)/t25-,26-,27-,28+,29+,30+/m1/s1 UDCLVFMWBHKQAS-OKXKEXSSSA-N 634734 US11814367, Compound 183 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634734&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349522 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1CCC2(C1)CCN(CC2)C(C)=O)c1ccccc1 InChI=1S/C33H42FN3O3/c1-22(2)24-9-11-26(12-10-24)30(25-7-5-4-6-8-25)35-31(39)29-19-28(34)21-37(29)32(40)27-13-14-33(20-27)15-17-36(18-16-33)23(3)38/h4-12,22,27-30H,13-21H2,1-3H3,(H,35,39)/t27?,28-,29+,30+/m1/s1 CRTQYBGQMXVAAG-WDSZSSPESA-N 634735 US11814367, Compound 184 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634735&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349523 CC(C)C(O)C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(cc1)C(C)C InChI=1S/C26H33FN2O3/c1-16(2)18-10-12-20(13-11-18)23(19-8-6-5-7-9-19)28-25(31)22-14-21(27)15-29(22)26(32)24(30)17(3)4/h5-13,16-17,21-24,30H,14-15H2,1-4H3,(H,28,31)/t21-,22+,23+,24?/m1/s1 OWEZLJDEGNNUMJ-XDXUOVRZSA-N 634736 US11814367, Compound 185 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634736&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349524 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)C(F)(F)F)c1ccccc1 InChI=1S/C25H27F4N3O3/c1-15(2)16-8-10-18(11-9-16)22(17-6-4-3-5-7-17)31-23(34)20-12-19(26)14-32(20)21(33)13-30-24(35)25(27,28)29/h3-11,15,19-20,22H,12-14H2,1-2H3,(H,30,35)(H,31,34)/t19-,20+,22+/m1/s1 QYTILDWOHPQVPK-URVUXULASA-N 634738 US11814367, Compound 187 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634738&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349525 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CC#N)c1ccccc1 InChI=1S/C24H26FN3O2/c1-16(2)17-8-10-19(11-9-17)23(18-6-4-3-5-7-18)27-24(30)21-14-20(25)15-28(21)22(29)12-13-26/h3-11,16,20-21,23H,12,14-15H2,1-2H3,(H,27,30)/t20-,21+,23+/m1/s1 ZQYATPYSLFKZKG-GIWBLDEGSA-N 634739 US11814367, Compound 188 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634739&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349526 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN(CC(N)=O)C(C)=O)c1ccccc1 InChI=1S/C27H33FN4O4/c1-17(2)19-9-11-21(12-10-19)26(20-7-5-4-6-8-20)30-27(36)23-13-22(28)14-32(23)25(35)16-31(18(3)33)15-24(29)34/h4-12,17,22-23,26H,13-16H2,1-3H3,(H2,29,34)(H,30,36)/t22-,23+,26+/m1/s1 FFNOFOFFWVKILE-UMFSSWHCSA-N 634740 US11814367, Compound 189 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634740&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349527 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCNC(C)=O)c1ccccc1 InChI=1S/C26H32FN3O3/c1-17(2)19-9-11-21(12-10-19)25(20-7-5-4-6-8-20)29-26(33)23-15-22(27)16-30(23)24(32)13-14-28-18(3)31/h4-12,17,22-23,25H,13-16H2,1-3H3,(H,28,31)(H,29,33)/t22-,23+,25+/m1/s1 DQCOJZPIUHEAAX-CUYJMHBOSA-N 634741 US11814367, Compound 190 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634741&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349528 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCCNC(C)=O)c1ccccc1 InChI=1S/C27H34FN3O3/c1-18(2)20-11-13-22(14-12-20)26(21-8-5-4-6-9-21)30-27(34)24-16-23(28)17-31(24)25(33)10-7-15-29-19(3)32/h4-6,8-9,11-14,18,23-24,26H,7,10,15-17H2,1-3H3,(H,29,32)(H,30,34)/t23-,24+,26+/m1/s1 TUYVZYIWOVYKAS-USZFVNFHSA-N 634742 US11814367, Compound 191 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634742&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349529 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CCCC1=O)c1ccccc1 InChI=1S/C27H32FN3O3/c1-18(2)19-10-12-21(13-11-19)26(20-7-4-3-5-8-20)29-27(34)23-15-22(28)16-31(23)25(33)17-30-14-6-9-24(30)32/h3-5,7-8,10-13,18,22-23,26H,6,9,14-17H2,1-2H3,(H,29,34)/t22-,23+,26+/m1/s1 IYRNYXSGIWFSIO-UMFSSWHCSA-N 634743 US11814367, Compound 192 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634743&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349530 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC1(C)COC1)c1ccccc1 InChI=1S/C27H34FN3O3/c1-18(2)19-9-11-21(12-10-19)25(20-7-5-4-6-8-20)30-26(33)23-13-22(28)15-31(23)24(32)14-29-27(3)16-34-17-27/h4-12,18,22-23,25,29H,13-17H2,1-3H3,(H,30,33)/t22-,23+,25+/m1/s1 NOQMNDOHUPRDBJ-CUYJMHBOSA-N 634744 US11814367, Compound 193 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634744&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349531 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc[nH]1)c1ccccc1 634745 US11814367, Compound 194 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634745&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349532 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnco1)c1ccccc1 InChI=1S/C26H28FN3O3/c1-17(2)18-8-10-20(11-9-18)25(19-6-4-3-5-7-19)29-26(32)23-12-21(27)15-30(23)24(31)13-22-14-28-16-33-22/h3-11,14,16-17,21,23,25H,12-13,15H2,1-2H3,(H,29,32)/t21-,23+,25+/m1/s1 USPZGNRXCSHPAY-VTZPFEBOSA-N 634746 US11814367, Compound 195 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634746&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349533 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@H](CCC(O)=O)NC(C)=O)c1ccccc1 InChI=1S/C28H34FN3O5/c1-17(2)19-9-11-21(12-10-19)26(20-7-5-4-6-8-20)31-27(36)24-15-22(29)16-32(24)28(37)23(30-18(3)33)13-14-25(34)35/h4-12,17,22-24,26H,13-16H2,1-3H3,(H,30,33)(H,31,36)(H,34,35)/t22-,23+,24+,26+/m1/s1 BXCLYNWWEABXSO-APFRJGHOSA-N 634747 US11814367, Compound 196 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634747&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349534 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@H](CCC(O)=O)NC(C)=O)c1ccccc1 InChI=1S/C28H34FN3O5/c1-17(2)19-9-11-21(12-10-19)26(20-7-5-4-6-8-20)31-27(36)24-15-22(29)16-32(24)28(37)23(30-18(3)33)13-14-25(34)35/h4-12,17,22-24,26H,13-16H2,1-3H3,(H,30,33)(H,31,36)(H,34,35)/t22-,23-,24+,26+/m1/s1 BXCLYNWWEABXSO-BIATYSSJSA-N 634748 US11814367, Compound 197 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634748&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349535 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNc1ncco1)c1ccccc1 InChI=1S/C26H29FN4O3/c1-17(2)18-8-10-20(11-9-18)24(19-6-4-3-5-7-19)30-25(33)22-14-21(27)16-31(22)23(32)15-29-26-28-12-13-34-26/h3-13,17,21-22,24H,14-16H2,1-2H3,(H,28,29)(H,30,33)/t21-,22+,24+/m1/s1 ZKMZAJJJIREMBV-GPXNEJASSA-N 634749 US11814367, Compound 198 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634749&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349536 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnnc1)c1ccccc1 InChI=1S/C25H28FN5O2/c1-17(2)18-8-10-20(11-9-18)24(19-6-4-3-5-7-19)29-25(33)22-12-21(26)13-31(22)23(32)14-30-15-27-28-16-30/h3-11,15-17,21-22,24H,12-14H2,1-2H3,(H,29,33)/t21-,22+,24+/m1/s1 HLJDYBCCSNSENO-GPXNEJASSA-N 634753 US11814367, Compound 202 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634753&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349537 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)C1CC1)c1ccccc1 InChI=1S/C25H30N2O2/c1-17(2)18-10-12-20(13-11-18)23(19-7-4-3-5-8-19)26-24(28)22-9-6-16-27(22)25(29)21-14-15-21/h3-5,7-8,10-13,17,21-23H,6,9,14-16H2,1-2H3,(H,26,28)/t22-,23-/m0/s1 LWSJSVXTRVEFRP-GOTSBHOMSA-N 634754 US11814367, Compound 203 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634754&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349538 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@H](O)CN1C(C)=O)c1ccccc1 InChI=1S/C23H28N2O3/c1-15(2)17-9-11-19(12-10-17)22(18-7-5-4-6-8-18)24-23(28)21-13-20(27)14-25(21)16(3)26/h4-12,15,20-22,27H,13-14H2,1-3H3,(H,24,28)/t20-,21-,22-/m0/s1 IMSQTAXOMUQGHH-FKBYEOEOSA-N 634755 US11814367, Compound 204 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634755&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349539 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(C)=O)c1ccccc1 InChI=1S/C23H28N2O3/c1-15(2)17-9-11-19(12-10-17)22(18-7-5-4-6-8-18)24-23(28)21-13-20(27)14-25(21)16(3)26/h4-12,15,20-22,27H,13-14H2,1-3H3,(H,24,28)/t20-,21+,22+/m1/s1 IMSQTAXOMUQGHH-FSSWDIPSSA-N 634756 US11814367, Compound 205 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634756&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349540 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1[C@@H](O)CCN1C(C)=O)c1ccccc1 InChI=1S/C23H28N2O3/c1-15(2)17-9-11-19(12-10-17)21(18-7-5-4-6-8-18)24-23(28)22-20(27)13-14-25(22)16(3)26/h4-12,15,20-22,27H,13-14H2,1-3H3,(H,24,28)/t20-,21-,22-/m0/s1 RQOAAEMRKHUZDO-FKBYEOEOSA-N 634757 US11814367, Compound 206 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634757&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349541 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(C)=O)c1ccccc1 InChI=1S/C23H27FN2O2/c1-15(2)17-9-11-19(12-10-17)22(18-7-5-4-6-8-18)25-23(28)21-13-20(24)14-26(21)16(3)27/h4-12,15,20-22H,13-14H2,1-3H3,(H,25,28)/t20-,21+,22+/m1/s1 USDVNHLSXBKOBW-FSSWDIPSSA-N 634758 US11814367, Compound 207 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634758&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349542 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@H](CC(N)=O)NC(C)=O)c1ccccc1 InChI=1S/C27H33FN4O4/c1-16(2)18-9-11-20(12-10-18)25(19-7-5-4-6-8-19)31-26(35)23-13-21(28)15-32(23)27(36)22(14-24(29)34)30-17(3)33/h4-12,16,21-23,25H,13-15H2,1-3H3,(H2,29,34)(H,30,33)(H,31,35)/t21-,22+,23+,25+/m1/s1 RHKOUHRRASCKNL-FVEXOFTDSA-N 634759 US11814367, Compound 208 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634759&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349543 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@H](CC(N)=O)NC(C)=O)c1ccccc1 InChI=1S/C27H33FN4O4/c1-16(2)18-9-11-20(12-10-18)25(19-7-5-4-6-8-19)31-26(35)23-13-21(28)15-32(23)27(36)22(14-24(29)34)30-17(3)33/h4-12,16,21-23,25H,13-15H2,1-3H3,(H2,29,34)(H,30,33)(H,31,35)/t21-,22-,23+,25+/m1/s1 RHKOUHRRASCKNL-AHCIIZGASA-N 634760 US11814367, Compound 209 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634760&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349544 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)OC(C)(C)C)c1ccccc1 InChI=1S/C28H37N3O4/c1-19(2)20-13-15-22(16-14-20)25(21-10-7-6-8-11-21)30-26(33)23-12-9-17-31(23)24(32)18-29-27(34)35-28(3,4)5/h6-8,10-11,13-16,19,23,25H,9,12,17-18H2,1-5H3,(H,29,34)(H,30,33)/t23-,25-/m0/s1 CPIBOFGQTJLMMV-ZCYQVOJMSA-N 634761 US11814367, Compound 210 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634761&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349545 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)CCC(N)=O)c1ccccc1 InChI=1S/C25H31N3O3/c1-17(2)18-10-12-20(13-11-18)24(19-7-4-3-5-8-19)27-25(31)21-9-6-16-28(21)23(30)15-14-22(26)29/h3-5,7-8,10-13,17,21,24H,6,9,14-16H2,1-2H3,(H2,26,29)(H,27,31)/t21-,24-/m0/s1 WBOIKQAYRDBTPX-URXFXBBRSA-N 634764 US11814367, Compound 213 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634764&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349546 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1CC[C@H](C)N1C(C)=O)c1ccccc1 InChI=1S/C24H30N2O2/c1-16(2)19-11-13-21(14-12-19)23(20-8-6-5-7-9-20)25-24(28)22-15-10-17(3)26(22)18(4)27/h5-9,11-14,16-17,22-23H,10,15H2,1-4H3,(H,25,28)/t17-,22-,23-/m0/s1 CAELKSSNLGBMIJ-RTFZILSDSA-N 634765 US11814367, Compound 214 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634765&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349547 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)Cc1ncco1)c1ccccc1 InChI=1S/C26H29N3O3/c1-18(2)19-10-12-21(13-11-19)25(20-7-4-3-5-8-20)28-26(31)22-9-6-15-29(22)24(30)17-23-27-14-16-32-23/h3-5,7-8,10-14,16,18,22,25H,6,9,15,17H2,1-2H3,(H,28,31)/t22-,25-/m0/s1 XAWNMVPPCMRHNZ-DHLKQENFSA-N 634767 US11814367, Compound 216 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634767&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349548 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CCOC1=O)c1ccccc1 InChI=1S/C26H30FN3O4/c1-17(2)18-8-10-20(11-9-18)24(19-6-4-3-5-7-19)28-25(32)22-14-21(27)15-30(22)23(31)16-29-12-13-34-26(29)33/h3-11,17,21-22,24H,12-16H2,1-2H3,(H,28,32)/t21-,22+,24+/m1/s1 RPAIEBXYOQNWHW-GPXNEJASSA-N 634768 US11814367, Compound 217 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634768&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349549 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CC1COC1)c1ccccc1 InChI=1S/C26H31FN2O3/c1-17(2)19-8-10-21(11-9-19)25(20-6-4-3-5-7-20)28-26(31)23-13-22(27)14-29(23)24(30)12-18-15-32-16-18/h3-11,17-18,22-23,25H,12-16H2,1-2H3,(H,28,31)/t22-,23+,25+/m1/s1 ZMZKWJWADZNIFG-CUYJMHBOSA-N 634769 US11814367, Compound 218 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634769&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349550 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CCOCC1=O)c1ccccc1 InChI=1S/C27H32FN3O4/c1-18(2)19-8-10-21(11-9-19)26(20-6-4-3-5-7-20)29-27(34)23-14-22(28)15-31(23)24(32)16-30-12-13-35-17-25(30)33/h3-11,18,22-23,26H,12-17H2,1-2H3,(H,29,34)/t22-,23+,26+/m1/s1 KWMXNNJIBNEEAR-UMFSSWHCSA-N 634770 US11814367, Compound 219 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634770&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349551 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccnn1C)c1ccccc1 InChI=1S/C27H31FN4O2/c1-18(2)19-9-11-21(12-10-19)26(20-7-5-4-6-8-20)30-27(34)24-15-22(28)17-32(24)25(33)16-23-13-14-29-31(23)3/h4-14,18,22,24,26H,15-17H2,1-3H3,(H,30,34)/t22-,24+,26+/m1/s1 LSCXQNXEMVLHJH-CWDLOFLHSA-N 634771 US11814367, Compound 220 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634771&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349552 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cccn1)c1ccccc1 InChI=1S/C26H29FN4O2/c1-18(2)19-9-11-21(12-10-19)25(20-7-4-3-5-8-20)29-26(33)23-15-22(27)16-31(23)24(32)17-30-14-6-13-28-30/h3-14,18,22-23,25H,15-17H2,1-2H3,(H,29,33)/t22-,23+,25+/m1/s1 WWBJWTCVIFGDEJ-CUYJMHBOSA-N 634573 US11814367, Compound 22::US11814367, Compound 221 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634573&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349553 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccnn1)c1ccccc1 InChI=1S/C25H28FN5O2/c1-17(2)18-8-10-20(11-9-18)24(19-6-4-3-5-7-19)28-25(33)22-14-21(26)15-31(22)23(32)16-30-13-12-27-29-30/h3-13,17,21-22,24H,14-16H2,1-2H3,(H,28,33)/t21-,22+,24+/m1/s1 BXQFPEGFEKFETK-GPXNEJASSA-N 634773 US11814367, Compound 222 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634773&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349554 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nn[nH]n1)c1ccccc1 634774 US11814367, Compound 223 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634774&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349555 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnco1)c1ccccc1 InChI=1S/C25H27FN4O3/c1-16(2)17-8-10-19(11-9-17)24(18-6-4-3-5-7-18)28-25(32)21-12-20(26)14-30(21)23(31)13-22-29-27-15-33-22/h3-11,15-16,20-21,24H,12-14H2,1-2H3,(H,28,32)/t20-,21+,24+/m1/s1 GLUAUIWKLRJTTK-DPLHUUCSSA-N 634775 US11814367, Compound 224 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634775&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349556 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nnnc1C)c1ccccc1 InChI=1S/C25H29FN6O2/c1-16(2)18-9-11-20(12-10-18)24(19-7-5-4-6-8-19)27-25(34)22-13-21(26)14-31(22)23(33)15-32-17(3)28-29-30-32/h4-12,16,21-22,24H,13-15H2,1-3H3,(H,27,34)/t21-,22+,24+/m1/s1 YONVHCRFLDNCAH-GPXNEJASSA-N 634777 US11814367, Compound 226 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634777&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349557 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nncn1C)c1ccccc1 InChI=1S/C26H30FN5O2/c1-17(2)18-9-11-20(12-10-18)25(19-7-5-4-6-8-19)29-26(34)22-13-21(27)15-32(22)24(33)14-23-30-28-16-31(23)3/h4-12,16-17,21-22,25H,13-15H2,1-3H3,(H,29,34)/t21-,22+,25+/m1/s1 OYQKLDLCRQZJPE-SLSDLSHTSA-N 634778 US11814367, Compound 227 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634778&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349558 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnnn1C)c1ccccc1 InChI=1S/C26H30FN5O2/c1-17(2)18-9-11-20(12-10-18)25(19-7-5-4-6-8-19)29-26(34)23-13-21(27)16-32(23)24(33)14-22-15-28-30-31(22)3/h4-12,15,17,21,23,25H,13-14,16H2,1-3H3,(H,29,34)/t21-,23+,25+/m1/s1 UHTKGSWFIUIZRF-VTZPFEBOSA-N 634779 US11814367, Compound 228 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634779&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349559 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cn(C)nn1)c1ccccc1 InChI=1S/C26H30FN5O2/c1-17(2)18-9-11-20(12-10-18)25(19-7-5-4-6-8-19)28-26(34)23-13-21(27)15-32(23)24(33)14-22-16-31(3)30-29-22/h4-12,16-17,21,23,25H,13-15H2,1-3H3,(H,28,34)/t21-,23+,25+/m1/s1 PJBKECGKVAJLIK-VTZPFEBOSA-N 634780 US11814367, Compound 229 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634780&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349560 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccon1)c1ccccc1 InChI=1S/C26H28FN3O3/c1-17(2)18-8-10-20(11-9-18)25(19-6-4-3-5-7-19)28-26(32)23-14-21(27)16-30(23)24(31)15-22-12-13-33-29-22/h3-13,17,21,23,25H,14-16H2,1-2H3,(H,28,32)/t21-,23+,25+/m1/s1 GJBPHDFPQHKPKR-VTZPFEBOSA-N 634782 US11814367, Compound 231 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634782&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349561 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nc(C)n[nH]1)c1ccccc1 634783 US11814367, Compound 232 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634783&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349562 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)(C)c1ncn[nH]1)c1ccccc1 634784 US11814367, Compound 233 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634784&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349563 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C)oc1=O)c1ccccc1 InChI=1S/C26H29FN4O4/c1-16(2)18-9-11-20(12-10-18)24(19-7-5-4-6-8-19)28-25(33)22-13-21(27)14-30(22)23(32)15-31-26(34)35-17(3)29-31/h4-12,16,21-22,24H,13-15H2,1-3H3,(H,28,33)/t21-,22+,24+/m1/s1 WYZKJCITJLPYPB-GPXNEJASSA-N 634787 US11814367, Compound 236 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634787&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349564 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(CNC(=O)OC(C)(C)C)o1)c1ccccc1 InChI=1S/C31H38FN5O5/c1-19(2)20-11-13-22(14-12-20)28(21-9-7-6-8-10-21)34-29(39)24-15-23(32)18-37(24)27(38)16-25-35-36-26(41-25)17-33-30(40)42-31(3,4)5/h6-14,19,23-24,28H,15-18H2,1-5H3,(H,33,40)(H,34,39)/t23-,24+,28+/m1/s1 GFVVIHQNDUMTLI-NYULUDCUSA-N 634788 US11814367, Compound 237 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634788&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349565 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(CN)o1)c1ccccc1 InChI=1S/C26H30FN5O3/c1-16(2)17-8-10-19(11-9-17)25(18-6-4-3-5-7-18)29-26(34)21-12-20(27)15-32(21)24(33)13-22-30-31-23(14-28)35-22/h3-11,16,20-21,25H,12-15,28H2,1-2H3,(H,29,34)/t20-,21+,25+/m1/s1 VMAGDQSKDUUBTQ-CZSZKKDXSA-N 634789 US11814367, Compound 238 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634789&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349566 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(CNC(C)=O)o1)c1ccccc1 InChI=1S/C28H32FN5O4/c1-17(2)19-9-11-21(12-10-19)27(20-7-5-4-6-8-20)31-28(37)23-13-22(29)16-34(23)26(36)14-24-32-33-25(38-24)15-30-18(3)35/h4-12,17,22-23,27H,13-16H2,1-3H3,(H,30,35)(H,31,37)/t22-,23+,27+/m1/s1 FCAMXAPFBUAVQE-KHVXQDHOSA-N 634790 US11814367, Compound 239 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634790&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349567 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nncc1CN)c1ccccc1 InChI=1S/C26H31FN6O2/c1-17(2)18-8-10-20(11-9-18)25(19-6-4-3-5-7-19)30-26(35)23-12-21(27)15-32(23)24(34)16-33-22(13-28)14-29-31-33/h3-11,14,17,21,23,25H,12-13,15-16,28H2,1-2H3,(H,30,35)/t21-,23+,25+/m1/s1 WNNMYRCDZARLOC-VTZPFEBOSA-N 634791 US11814367, Compound 240 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634791&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349568 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nncc1CN(C)C)c1ccccc1 InChI=1S/C28H35FN6O2/c1-19(2)20-10-12-22(13-11-20)27(21-8-6-5-7-9-21)31-28(37)25-14-23(29)16-34(25)26(36)18-35-24(15-30-32-35)17-33(3)4/h5-13,15,19,23,25,27H,14,16-18H2,1-4H3,(H,31,37)/t23-,25+,27+/m1/s1 NJJOLQOXRXBFKR-NIYJGHKDSA-N 634792 US11814367, Compound 241 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634792&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349569 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(CN(C)C)o1)c1ccccc1 InChI=1S/C28H34FN5O3/c1-18(2)19-10-12-21(13-11-19)27(20-8-6-5-7-9-20)30-28(36)23-14-22(29)16-34(23)26(35)15-24-31-32-25(37-24)17-33(3)4/h5-13,18,22-23,27H,14-17H2,1-4H3,(H,30,36)/t22-,23+,27+/m1/s1 AAQQJWAWXLCBJK-KHVXQDHOSA-N 634793 US11814367, Compound 242 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634793&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349570 CC(C)c1ccc(cc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nncc1CNC(C)=O)c1ccccc1 InChI=1S/C28H33FN6O3/c1-18(2)20-9-11-22(12-10-20)27(21-7-5-4-6-8-21)32-28(38)25-13-23(29)16-34(25)26(37)17-35-24(15-31-33-35)14-30-19(3)36/h4-12,15,18,23,25,27H,13-14,16-17H2,1-3H3,(H,30,36)(H,32,38)/t23-,25+,27+/m1/s1 LPOAHZZUKJBZEE-NIYJGHKDSA-N 634794 US11814367, Compound 243 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634794&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349571 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 634795 US11814367, Compound 244 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634795&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349572 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1CCCN1C(C)=O)c1ccccc1 InChI=1S/C22H27N3O2/c1-15(2)18-11-12-19(23-14-18)21(17-8-5-4-6-9-17)24-22(27)20-10-7-13-25(20)16(3)26/h4-6,8-9,11-12,14-15,20-21H,7,10,13H2,1-3H3,(H,24,27)/t20-,21-/m0/s1 IMOKDWIAZJEIEV-SFTDATJTSA-N 634796 US11814367, Compound 245 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634796&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349573 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c(C)n[nH]c1C)c1ccccc1 634797 US11814367, Compound 246 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634797&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349574 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cccc2ncccc12)c1ccccc1 InChI=1S/C31H31FN4O2/c1-20(2)23-13-14-27(34-18-23)30(21-8-4-3-5-9-21)35-31(38)28-17-24(32)19-36(28)29(37)16-22-10-6-12-26-25(22)11-7-15-33-26/h3-15,18,20,24,28,30H,16-17,19H2,1-2H3,(H,35,38)/t24-,28+,30+/m1/s1 WIWBIQFOJKIYHB-HZXVKSMZSA-N 634798 US11814367, Compound 247 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634798&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349575 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnc2ccccc12)c1ccccc1 InChI=1S/C29H30FN5O2/c1-19(2)21-12-13-24(31-15-21)28(20-8-4-3-5-9-20)33-29(37)26-14-22(30)16-35(26)27(36)17-34-18-32-23-10-6-7-11-25(23)34/h3-13,15,18-19,22,26,28H,14,16-17H2,1-2H3,(H,33,37)/t22-,26+,28+/m1/s1 GRNDWUBMUNQXQQ-ZEZZXZOMSA-N 634799 US11814367, Compound 248 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634799&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349576 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C)c(=O)[nH]c1=O)c1ccccc1 634800 US11814367, Compound 249 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634800&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349577 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N(C)C)c1ccccc1 InChI=1S/C25H32FN5O3/c1-16(2)18-10-11-20(27-13-18)23(17-8-6-5-7-9-17)29-24(33)21-12-19(26)15-31(21)22(32)14-28-25(34)30(3)4/h5-11,13,16,19,21,23H,12,14-15H2,1-4H3,(H,28,34)(H,29,33)/t19-,21+,23+/m1/s1 CNEWCOCQRVQETR-NWSQWKLXSA-N 634801 US11814367, Compound 250::US11814367, Compound 273 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634801&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349578 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)COC(=O)N(C)C)c1ccccc1 InChI=1S/C25H31FN4O4/c1-16(2)18-10-11-20(27-13-18)23(17-8-6-5-7-9-17)28-24(32)21-12-19(26)14-30(21)22(31)15-34-25(33)29(3)4/h5-11,13,16,19,21,23H,12,14-15H2,1-4H3,(H,28,32)/t19-,21+,23+/m1/s1 UKBAEMAXUDSRQC-NWSQWKLXSA-N 634802 US11814367, Compound 251 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634802&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349579 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnnn1)c1ccccc1 InChI=1S/C23H26FN7O2/c1-15(2)17-8-9-19(25-11-17)22(16-6-4-3-5-7-16)27-23(33)20-10-18(24)12-31(20)21(32)13-30-14-26-28-29-30/h3-9,11,14-15,18,20,22H,10,12-13H2,1-2H3,(H,27,33)/t18-,20+,22+/m1/s1 GHZPVTLRKMNXJI-CBQOVEMMSA-N 634803 US11814367, Compound 252 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634803&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349580 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(o1)C(F)F)c1ccccc1 InChI=1S/C25H26F3N5O3/c1-14(2)16-8-9-18(29-12-16)22(15-6-4-3-5-7-15)30-24(35)19-10-17(26)13-33(19)21(34)11-20-31-32-25(36-20)23(27)28/h3-9,12,14,17,19,22-23H,10-11,13H2,1-2H3,(H,30,35)/t17-,19+,22+/m1/s1 GAXJTWMXJMKPDK-LZNRXBQRSA-N 634804 US11814367, Compound 253 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634804&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349581 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nnnc1C(F)F)c1ccccc1 InChI=1S/C24H26F3N7O2/c1-14(2)16-8-9-18(28-11-16)21(15-6-4-3-5-7-15)29-24(36)19-10-17(25)12-33(19)20(35)13-34-23(22(26)27)30-31-32-34/h3-9,11,14,17,19,21-22H,10,12-13H2,1-2H3,(H,29,36)/t17-,19+,21+/m1/s1 BVQVBBMLVMHROT-LMNJBCLMSA-N 634805 US11814367, Compound 254 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634805&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349582 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nnc(n1)C(F)(F)F)c1ccccc1 InChI=1S/C24H25F4N7O2/c1-14(2)16-8-9-18(29-11-16)21(15-6-4-3-5-7-15)30-22(37)19-10-17(25)12-34(19)20(36)13-35-32-23(31-33-35)24(26,27)28/h3-9,11,14,17,19,21H,10,12-13H2,1-2H3,(H,30,37)/t17-,19+,21+/m1/s1 QDNRZQJWGHOXPQ-LMNJBCLMSA-N 634806 US11814367, Compound 255 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634806&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349583 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nnc(n1)C(F)F)c1ccccc1 InChI=1S/C24H26F3N7O2/c1-14(2)16-8-9-18(28-11-16)21(15-6-4-3-5-7-15)29-24(36)19-10-17(25)12-33(19)20(35)13-34-31-23(22(26)27)30-32-34/h3-9,11,14,17,19,21-22H,10,12-13H2,1-2H3,(H,29,36)/t17-,19+,21+/m1/s1 MNUXFRNEVXZIEK-LMNJBCLMSA-N 634807 US11814367, Compound 256 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634807&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349584 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cccc2nc(C)ccc12)c1ccccc1 InChI=1S/C32H33FN4O2/c1-20(2)24-13-15-28(34-18-24)31(22-8-5-4-6-9-22)36-32(39)29-17-25(33)19-37(29)30(38)16-23-10-7-11-27-26(23)14-12-21(3)35-27/h4-15,18,20,25,29,31H,16-17,19H2,1-3H3,(H,36,39)/t25-,29+,31+/m1/s1 KAWYFXHIKRMWAS-IDTFQEBLSA-N 634808 US11814367, Compound 257 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634808&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349585 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cccn2c1n[nH]c2=O)c1ccccc1 634809 US11814367, Compound 258 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634809 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634809&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349586 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ncc(n1)N(C)C)c1ccccc1 InChI=1S/C26H32FN7O2/c1-17(2)19-10-11-21(28-13-19)25(18-8-6-5-7-9-18)30-26(36)22-12-20(27)15-33(22)24(35)16-34-29-14-23(31-34)32(3)4/h5-11,13-14,17,20,22,25H,12,15-16H2,1-4H3,(H,30,36)/t20-,22+,25+/m1/s1 RRCNKAOZBCQFLR-KJWPAHLWSA-N 634810 US11814367, Compound 259 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634810&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349587 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(nn1)N(C)C)c1ccccc1 InChI=1S/C26H32FN7O2/c1-17(2)19-10-11-21(28-13-19)25(18-8-6-5-7-9-18)29-26(36)22-12-20(27)14-34(22)24(35)16-33-15-23(30-31-33)32(3)4/h5-11,13,15,17,20,22,25H,12,14,16H2,1-4H3,(H,29,36)/t20-,22+,25+/m1/s1 FWULMSZHOBPPJD-KJWPAHLWSA-N 634811 US11814367, Compound 260 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634811&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349588 CNC(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(cn1)C(C)C InChI=1S/C24H30FN5O3/c1-15(2)17-9-10-19(27-12-17)22(16-7-5-4-6-8-16)29-23(32)20-11-18(25)14-30(20)21(31)13-28-24(33)26-3/h4-10,12,15,18,20,22H,11,13-14H2,1-3H3,(H,29,32)(H2,26,28,33)/t18-,20+,22+/m1/s1 MBMLMSIWVUVDLR-CBQOVEMMSA-N 634812 US11814367, Compound 261 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634812&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349589 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(N)=O)c1ccccc1 InChI=1S/C23H28FN5O3/c1-14(2)16-8-9-18(26-11-16)21(15-6-4-3-5-7-15)28-22(31)19-10-17(24)13-29(19)20(30)12-27-23(25)32/h3-9,11,14,17,19,21H,10,12-13H2,1-2H3,(H,28,31)(H3,25,27,32)/t17-,19+,21+/m1/s1 DZCJBHPCCVGCPP-LMNJBCLMSA-N 634813 US11814367, Compound 262 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634813&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349590 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nn(C)c(=O)[nH]1)c1ccccc1 634814 US11814367, Compound 263 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634814&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349591 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1n[nH]c(=O)n1C)c1ccccc1 634815 US11814367, Compound 264 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634815&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349592 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CCC1)c1ccccc1 InChI=1S/C26H32FN5O3/c1-17(2)19-9-10-21(28-14-19)24(18-7-4-3-5-8-18)30-25(34)22-13-20(27)16-32(22)23(33)15-29-26(35)31-11-6-12-31/h3-5,7-10,14,17,20,22,24H,6,11-13,15-16H2,1-2H3,(H,29,35)(H,30,34)/t20-,22+,24+/m1/s1 TXONDXOBMPKAEH-SFLYRZDNSA-N 634816 US11814367, Compound 265 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634816&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349593 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nn(C)c(=O)o1)c1ccccc1 InChI=1S/C25H28FN5O4/c1-15(2)17-9-10-19(27-13-17)23(16-7-5-4-6-8-16)28-24(33)20-11-18(26)14-31(20)22(32)12-21-29-30(3)25(34)35-21/h4-10,13,15,18,20,23H,11-12,14H2,1-3H3,(H,28,33)/t18-,20+,23+/m1/s1 QLUBVRGJFXMLDI-RFWXGWTQSA-N 634817 US11814367, Compound 266 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634817&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349594 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1[nH]nnc1C(F)(F)F)c1ccccc1 634819 US11814367, Compound 268 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634819&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349595 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNc1ccnc(C)n1)c1ccccc1 InChI=1S/C27H31FN6O2/c1-17(2)20-9-10-22(30-14-20)26(19-7-5-4-6-8-19)33-27(36)23-13-21(28)16-34(23)25(35)15-31-24-11-12-29-18(3)32-24/h4-12,14,17,21,23,26H,13,15-16H2,1-3H3,(H,33,36)(H,29,31,32)/t21-,23+,26+/m1/s1 ZHZYRXKSJQRIQO-JJTGBXKASA-N 634820 US11814367, Compound 269 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634820&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349596 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ncco1)c1ccccc1 InChI=1S/C25H27FN4O3/c1-16(2)18-8-9-20(28-14-18)24(17-6-4-3-5-7-17)29-25(32)21-12-19(26)15-30(21)23(31)13-22-27-10-11-33-22/h3-11,14,16,19,21,24H,12-13,15H2,1-2H3,(H,29,32)/t19-,21+,24+/m1/s1 KEUNMCCAMSAYIB-IZIIKQMZSA-N 634821 US11814367, Compound 270 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634821&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349597 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ncc(C)o1)c1ccccc1 InChI=1S/C26H29FN4O3/c1-16(2)19-9-10-21(28-14-19)25(18-7-5-4-6-8-18)30-26(33)22-11-20(27)15-31(22)24(32)12-23-29-13-17(3)34-23/h4-10,13-14,16,20,22,25H,11-12,15H2,1-3H3,(H,30,33)/t20-,22+,25+/m1/s1 RCXPKKXNZOUFOM-KJWPAHLWSA-N 634822 US11814367, Compound 271 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634822&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349598 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nc(C)co1)c1ccccc1 InChI=1S/C26H29FN4O3/c1-16(2)19-9-10-21(28-13-19)25(18-7-5-4-6-8-18)30-26(33)22-11-20(27)14-31(22)24(32)12-23-29-17(3)15-34-23/h4-10,13,15-16,20,22,25H,11-12,14H2,1-3H3,(H,30,33)/t20-,22+,25+/m1/s1 GXYCIDPFBKHKAZ-KJWPAHLWSA-N 634823 US11814367, Compound 272 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634823&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349599 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N(C)C)c1ccccc1 InChI=1S/C25H32FN5O3/c1-16(2)18-10-11-20(27-13-18)23(17-8-6-5-7-9-17)29-24(33)21-12-19(26)15-31(21)22(32)14-28-25(34)30(3)4/h5-11,13,16,19,21,23H,12,14-15H2,1-4H3,(H,28,34)(H,29,33)/t19-,21+,23+/m1/s1 CNEWCOCQRVQETR-NWSQWKLXSA-N 634801 US11814367, Compound 250::US11814367, Compound 273 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634801&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349600 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@H](C)NC(=O)N(C)C)c1ccccc1 InChI=1S/C26H34FN5O3/c1-16(2)19-11-12-21(28-14-19)23(18-9-7-6-8-10-18)30-24(33)22-13-20(27)15-32(22)25(34)17(3)29-26(35)31(4)5/h6-12,14,16-17,20,22-23H,13,15H2,1-5H3,(H,29,35)(H,30,33)/t17-,20-,22+,23+/m1/s1 FAVYKGKGVPWIMX-QRRACGJLSA-N 634825 US11814367, Compound 274 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634825&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349601 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nc(C)oc1=O)c1ccccc1 InChI=1S/C25H28FN5O4/c1-15(2)18-9-10-20(27-12-18)23(17-7-5-4-6-8-17)28-24(33)21-11-19(26)13-30(21)22(32)14-31-25(34)35-16(3)29-31/h4-10,12,15,19,21,23H,11,13-14H2,1-3H3,(H,28,33)/t19-,21+,23+/m1/s1 JPJYZOIEWDTKGV-NWSQWKLXSA-N 634826 US11814367, Compound 275 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634826&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349602 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ncc(n1)N1CCC1)c1ccccc1 InChI=1S/C27H32FN7O2/c1-18(2)20-9-10-22(29-14-20)26(19-7-4-3-5-8-19)31-27(37)23-13-21(28)16-34(23)25(36)17-35-30-15-24(32-35)33-11-6-12-33/h3-5,7-10,14-15,18,21,23,26H,6,11-13,16-17H2,1-2H3,(H,31,37)/t21-,23+,26+/m1/s1 DRQHBJIZYAKNSV-JJTGBXKASA-N 634827 US11814367, Compound 276 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634827&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349603 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ncc(n1)N1CC(F)(F)C1)c1ccccc1 InChI=1S/C27H30F3N7O2/c1-17(2)19-8-9-21(31-11-19)25(18-6-4-3-5-7-18)33-26(39)22-10-20(28)13-36(22)24(38)14-37-32-12-23(34-37)35-15-27(29,30)16-35/h3-9,11-12,17,20,22,25H,10,13-16H2,1-2H3,(H,33,39)/t20-,22+,25+/m1/s1 HOLSLEBZEZEAKI-KJWPAHLWSA-N 634828 US11814367, Compound 277 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634828&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349604 CCN(CC)c1cnn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(cn2)C(C)C)n1 InChI=1S/C28H36FN7O2/c1-5-34(6-2)25-16-31-36(33-25)18-26(37)35-17-22(29)14-24(35)28(38)32-27(20-10-8-7-9-11-20)23-13-12-21(15-30-23)19(3)4/h7-13,15-16,19,22,24,27H,5-6,14,17-18H2,1-4H3,(H,32,38)/t22-,24+,27+/m1/s1 FAIBJWXKQDQSFQ-SHQBLQIYSA-N 634829 US11814367, Compound 278 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634829&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349605 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1[C@H]2C[C@H]2CN1C(=O)Cc1cnn[nH]1)c1ccccc1 634830 US11814367, Compound 279 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634830&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349606 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1CC[C@H](C)N1C(=O)Cc1cnn[nH]1)c1ccccc1 634831 US11814367, Compound 280 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634831&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349607 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CCN(CC(F)(F)F)CC1)c1ccccc1 InChI=1S/C29H36F4N6O3/c1-19(2)21-8-9-23(34-15-21)26(20-6-4-3-5-7-20)36-27(41)24-14-22(30)17-39(24)25(40)16-35-28(42)38-12-10-37(11-13-38)18-29(31,32)33/h3-9,15,19,22,24,26H,10-14,16-18H2,1-2H3,(H,35,42)(H,36,41)/t22-,24+,26+/m1/s1 FRHYYWVIUWVLSR-CWDLOFLHSA-N 634832 US11814367, Compound 281 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634832&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349608 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CCN(CC2CC2)CC1)c1ccccc1 InChI=1S/C31H41FN6O3/c1-21(2)24-10-11-26(33-17-24)29(23-6-4-3-5-7-23)35-30(40)27-16-25(32)20-38(27)28(39)18-34-31(41)37-14-12-36(13-15-37)19-22-8-9-22/h3-7,10-11,17,21-22,25,27,29H,8-9,12-16,18-20H2,1-2H3,(H,34,41)(H,35,40)/t25-,27+,29+/m1/s1 BRYRBYRSXZWYLW-WBJKNQCFSA-N 634833 US11814367, Compound 282 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634833&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349609 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CCN(C)CC1)c1ccccc1 InChI=1S/C28H37FN6O3/c1-19(2)21-9-10-23(30-16-21)26(20-7-5-4-6-8-20)32-27(37)24-15-22(29)18-35(24)25(36)17-31-28(38)34-13-11-33(3)12-14-34/h4-10,16,19,22,24,26H,11-15,17-18H2,1-3H3,(H,31,38)(H,32,37)/t22-,24+,26+/m1/s1 MGRDHFQKPXOGPJ-CWDLOFLHSA-N 634834 US11814367, Compound 283 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634834&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349610 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1n[nH]c(=O)[nH]1)c1ccccc1 InChI=1S/C24H25FN6O3/c1-14(2)16-8-9-18(26-12-16)22(15-6-4-3-5-7-15)28-23(33)19-10-17(25)13-31(19)21(32)11-20-27-24(34)30-29-20/h3-9,12,14,17,19,22H,10-11,13H2,1-2H3,(H,28,33)/t17-,19+,22+/m1/s1 APHFRCSGKAWXFM-LZNRXBQRSA-N 634835 US11814367, Compound 284 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634835&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349611 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCc1n[nH]c(=O)[nH]1)c1ccccc1 InChI=1S/C25H27FN6O3/c1-15(2)17-8-9-19(27-13-17)23(16-6-4-3-5-7-16)29-24(34)20-12-18(26)14-32(20)22(33)11-10-21-28-25(35)31-30-21/h3-9,13,15,18,20,23H,10-12,14H2,1-2H3,(H,29,34)/t18-,20+,23+/m1/s1 ZFOZEXJDZXLAJV-RFWXGWTQSA-N 634838 US11814367, Compound 287 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634838&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349612 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cn[nH]c1=O)c1ccccc1 634839 US11814367, Compound 288 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634839&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349613 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CCn1nc2ccccn2c1=O)c1ccccc1 InChI=1S/C29H31FN6O3/c1-19(2)21-11-12-23(31-17-21)27(20-8-4-3-5-9-20)32-28(38)24-16-22(30)18-35(24)26(37)13-15-36-29(39)34-14-7-6-10-25(34)33-36/h3-12,14,17,19,22,24,27H,13,15-16,18H2,1-2H3,(H,32,38)/t22-,24+,27+/m1/s1 OESXDTMWEDZLEI-SHQBLQIYSA-N 634840 US11814367, Compound 289 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634840&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349614 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CC(F)(F)C1)c1ccccc1 InChI=1S/C26H30F3N5O3/c1-16(2)18-8-9-20(30-11-18)23(17-6-4-3-5-7-17)32-24(36)21-10-19(27)13-34(21)22(35)12-31-25(37)33-14-26(28,29)15-33/h3-9,11,16,19,21,23H,10,12-15H2,1-2H3,(H,31,37)(H,32,36)/t19-,21+,23+/m1/s1 LORLBFSTXDZTNF-NWSQWKLXSA-N 634841 US11814367, Compound 290 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634841&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349615 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CC(C1)C(F)(F)F)c1ccccc1 InChI=1S/C27H31F4N5O3/c1-16(2)18-8-9-21(32-11-18)24(17-6-4-3-5-7-17)34-25(38)22-10-20(28)15-36(22)23(37)12-33-26(39)35-13-19(14-35)27(29,30)31/h3-9,11,16,19-20,22,24H,10,12-15H2,1-2H3,(H,33,39)(H,34,38)/t20-,22+,24+/m1/s1 HDYRWDDQLWCKQL-SFLYRZDNSA-N 634842 US11814367, Compound 291 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634842&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349616 CC(C)c1ccc(nc1)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cccn1)c1ccccc1 InChI=1S/C25H28FN5O2/c1-17(2)19-9-10-21(27-14-19)24(18-7-4-3-5-8-18)29-25(33)22-13-20(26)15-31(22)23(32)16-30-12-6-11-28-30/h3-12,14,17,20,22,24H,13,15-16H2,1-2H3,(H,29,33)/t20-,22+,24+/m1/s1 HJQOOBNFNFXFBX-SFLYRZDNSA-N 634843 US11814367, Compound 292 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634843&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349617 FC(F)c1nnnn1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C24H23F4N7O2/c25-15-10-18(34(11-15)19(36)12-35-23(21(26)27)31-32-33-35)24(37)30-20(14-4-2-1-3-5-14)17-9-8-16(13-6-7-13)22(28)29-17/h1-5,8-9,13,15,18,20-21H,6-7,10-12H2,(H,30,37)/t15-,18+,20+/m1/s1 YZAPCISAJZDABO-BPAFIMBUSA-N 634844 US11814367, Compound 293 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634844&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349618 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cnc2ccccc12)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C29H27F2N5O2/c30-20-14-25(36(15-20)26(37)16-35-17-32-22-8-4-5-9-24(22)35)29(38)34-27(19-6-2-1-3-7-19)23-13-12-21(18-10-11-18)28(31)33-23/h1-9,12-13,17-18,20,25,27H,10-11,14-16H2,(H,34,38)/t20-,25+,27+/m1/s1 CAAQWGIUWXCDPY-RAHIQWLESA-N 634845 US11814367, Compound 294 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634845&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349619 Cc1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)c(=O)[nH]c1=O 634846 US11814367, Compound 295 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634846&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349620 F[C@@H]1C[C@H](N(C1)C(=O)Cn1cnnc1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C24H24F2N6O2/c25-17-10-20(32(11-17)21(33)12-31-13-27-28-14-31)24(34)30-22(16-4-2-1-3-5-16)19-9-8-18(15-6-7-15)23(26)29-19/h1-5,8-9,13-15,17,20,22H,6-7,10-12H2,(H,30,34)/t17-,20+,22+/m1/s1 SJFYPIFGNSEIND-AGHHOFFYSA-N 634847 US11814367, Compound 296 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634847&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349621 CN(C)c1cnnn1CC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C26H29F2N7O2/c1-33(2)22-13-29-32-35(22)15-23(36)34-14-18(27)12-21(34)26(37)31-24(17-6-4-3-5-7-17)20-11-10-19(16-8-9-16)25(28)30-20/h3-7,10-11,13,16,18,21,24H,8-9,12,14-15H2,1-2H3,(H,31,37)/t18-,21+,24+/m1/s1 VTEIWDRHIKLWBV-ZHRMCQFGSA-N 634849 US11814367, Compound 298 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634849&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349622 CN(C)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)nn1 InChI=1S/C26H29F2N7O2/c1-33(2)22-14-34(32-31-22)15-23(36)35-13-18(27)12-21(35)26(37)30-24(17-6-4-3-5-7-17)20-11-10-19(16-8-9-16)25(28)29-20/h3-7,10-11,14,16,18,21,24H,8-9,12-13,15H2,1-2H3,(H,30,37)/t18-,21+,24+/m1/s1 VQULISCHXIHZGB-ZHRMCQFGSA-N 634850 US11814367, Compound 299 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634850&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349623 CN(C)C(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C25H29F2N5O3/c1-31(2)25(35)28-13-21(33)32-14-17(26)12-20(32)24(34)30-22(16-6-4-3-5-7-16)19-11-10-18(15-8-9-15)23(27)29-19/h3-7,10-11,15,17,20,22H,8-9,12-14H2,1-2H3,(H,28,35)(H,30,34)/t17-,20+,22+/m1/s1 PLPOFTMMEIPSLN-AGHHOFFYSA-N 634851 US11814367, Compound 300 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634851&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349624 CNC(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C24H27F2N5O3/c1-27-24(34)28-12-20(32)31-13-16(25)11-19(31)23(33)30-21(15-5-3-2-4-6-15)18-10-9-17(14-7-8-14)22(26)29-18/h2-6,9-10,14,16,19,21H,7-8,11-13H2,1H3,(H,30,33)(H2,27,28,34)/t16-,19+,21+/m1/s1 FPACQMZJGZKUGA-PBEJRMEISA-N 634852 US11814367, Compound 301 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634852&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349625 NC(=O)NCC(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C23H25F2N5O3/c24-15-10-18(30(12-15)19(31)11-27-23(26)33)22(32)29-20(14-4-2-1-3-5-14)17-9-8-16(13-6-7-13)21(25)28-17/h1-5,8-9,13,15,18,20H,6-7,10-12H2,(H,29,32)(H3,26,27,33)/t15-,18+,20+/m1/s1 KMUXAWARPTUZQD-BPAFIMBUSA-N 634853 US11814367, Compound 302 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634853&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349626 Cn1nc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)[nH]c1=O 634854 US11814367, Compound 303 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634854&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349627 Cn1c(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)n[nH]c1=O 634855 US11814367, Compound 304 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634855&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349628 Cn1nc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)oc1=O InChI=1S/C25H25F2N5O4/c1-31-25(35)36-20(30-31)12-21(33)32-13-16(26)11-19(32)24(34)29-22(15-5-3-2-4-6-15)18-10-9-17(14-7-8-14)23(27)28-18/h2-6,9-10,14,16,19,22H,7-8,11-13H2,1H3,(H,29,34)/t16-,19+,22+/m1/s1 MRFCKWFMDYEPCS-WVBUVRCRSA-N 634857 US11814367, Compound 306 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634857&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349629 F[C@@H]1C[C@H](N(C1)C(=O)Cc1[nH]nnc1C(F)(F)F)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 634858 US11814367, Compound 307 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634858&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349630 Nc1nccc(NCC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)n1 InChI=1S/C26H27F2N7O2/c27-17-12-20(35(14-17)22(36)13-31-21-10-11-30-26(29)33-21)25(37)34-23(16-4-2-1-3-5-16)19-9-8-18(15-6-7-15)24(28)32-19/h1-5,8-11,15,17,20,23H,6-7,12-14H2,(H,34,37)(H3,29,30,31,33)/t17-,20+,23+/m1/s1 QJYIKJPKGDNNIS-MONBJTKQSA-N 634859 US11814367, Compound 308 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634859&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349631 F[C@@H]1C[C@H](N(C1)C(=O)CNc1ncco1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C25H25F2N5O3/c26-17-12-20(32(14-17)21(33)13-29-25-28-10-11-35-25)24(34)31-22(16-4-2-1-3-5-16)19-9-8-18(15-6-7-15)23(27)30-19/h1-5,8-11,15,17,20,22H,6-7,12-14H2,(H,28,29)(H,31,34)/t17-,20+,22+/m1/s1 BCECUOHYILIMLB-AGHHOFFYSA-N 634860 US11814367, Compound 309 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634860&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349632 C[C@H](NC(=O)N(C)C)C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C26H31F2N5O3/c1-15(29-26(36)32(2)3)25(35)33-14-18(27)13-21(33)24(34)31-22(17-7-5-4-6-8-17)20-12-11-19(16-9-10-16)23(28)30-20/h4-8,11-12,15-16,18,21-22H,9-10,13-14H2,1-3H3,(H,29,36)(H,31,34)/t15-,18+,21-,22-/m0/s1 DMJXUXNRKJYMIB-XSLZUNGDSA-N 634861 US11814367, Compound 310 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634861&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349633 C[C@@H](NC(=O)N(C)C)C(=O)N1C[C@H](F)C[C@H]1C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C26H31F2N5O3/c1-15(29-26(36)32(2)3)25(35)33-14-18(27)13-21(33)24(34)31-22(17-7-5-4-6-8-17)20-12-11-19(16-9-10-16)23(28)30-20/h4-8,11-12,15-16,18,21-22H,9-10,13-14H2,1-3H3,(H,29,36)(H,31,34)/t15-,18-,21+,22+/m1/s1 DMJXUXNRKJYMIB-ALALXSPKSA-N 634862 US11814367, Compound 311 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634862&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349634 F[C@@H]1C[C@H](N(C1)C(=O)Cc1ncco1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C25H24F2N4O3/c26-17-12-20(31(14-17)22(32)13-21-28-10-11-34-21)25(33)30-23(16-4-2-1-3-5-16)19-9-8-18(15-6-7-15)24(27)29-19/h1-5,8-11,15,17,20,23H,6-7,12-14H2,(H,30,33)/t17-,20+,23+/m1/s1 GAGJEQKLPHEJGB-MONBJTKQSA-N 634863 US11814367, Compound 312 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634863&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349635 Cc1cnc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)o1 InChI=1S/C26H26F2N4O3/c1-15-13-29-22(35-15)12-23(33)32-14-18(27)11-21(32)26(34)31-24(17-5-3-2-4-6-17)20-10-9-19(16-7-8-16)25(28)30-20/h2-6,9-10,13,16,18,21,24H,7-8,11-12,14H2,1H3,(H,31,34)/t18-,21+,24+/m1/s1 GAVBKFPPEDMJNB-ZHRMCQFGSA-N 634864 US11814367, Compound 313 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634864&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349636 Cc1coc(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)n1 InChI=1S/C26H26F2N4O3/c1-15-14-35-22(29-15)12-23(33)32-13-18(27)11-21(32)26(34)31-24(17-5-3-2-4-6-17)20-10-9-19(16-7-8-16)25(28)30-20/h2-6,9-10,14,16,18,21,24H,7-8,11-13H2,1H3,(H,31,34)/t18-,21+,24+/m1/s1 FILKICMELBITTQ-ZHRMCQFGSA-N 634865 US11814367, Compound 314 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634865&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349637 F[C@@H]1C[C@H](N(C1)C(=O)CNC(=O)N1CC(F)(F)C1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C26H27F4N5O3/c27-17-10-20(35(12-17)21(36)11-31-25(38)34-13-26(29,30)14-34)24(37)33-22(16-4-2-1-3-5-16)19-9-8-18(15-6-7-15)23(28)32-19/h1-5,8-9,15,17,20,22H,6-7,10-14H2,(H,31,38)(H,33,37)/t17-,20+,22+/m1/s1 KCENTJDZHADJCZ-AGHHOFFYSA-N 634866 US11814367, Compound 315 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634866&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349638 Cc1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)c(=O)o1 InChI=1S/C25H25F2N5O4/c1-14-30-32(25(35)36-14)13-21(33)31-12-17(26)11-20(31)24(34)29-22(16-5-3-2-4-6-16)19-10-9-18(15-7-8-15)23(27)28-19/h2-6,9-10,15,17,20,22H,7-8,11-13H2,1H3,(H,29,34)/t17-,20+,22+/m1/s1 VNMFDRJCCVRBCN-AGHHOFFYSA-N 634867 US11814367, Compound 316 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634867&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349639 F[C@@H]1C[C@H](N(C1)C(=O)Cn1ncc(n1)N1CCC1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C27H29F2N7O2/c28-19-13-22(35(15-19)24(37)16-36-30-14-23(33-36)34-11-4-12-34)27(38)32-25(18-5-2-1-3-6-18)21-10-9-20(17-7-8-17)26(29)31-21/h1-3,5-6,9-10,14,17,19,22,25H,4,7-8,11-13,15-16H2,(H,32,38)/t19-,22+,25+/m1/s1 MFFKBDYVRYZYPY-WPWBMXPQSA-N 634868 US11814367, Compound 317 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634868&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349640 F[C@@H]1C[C@H](N(C1)C(=O)Cn1ncc(n1)N1CC(F)(F)C1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 InChI=1S/C27H27F4N7O2/c28-18-10-21(37(12-18)23(39)13-38-32-11-22(35-38)36-14-27(30,31)15-36)26(40)34-24(17-4-2-1-3-5-17)20-9-8-19(16-6-7-16)25(29)33-20/h1-5,8-9,11,16,18,21,24H,6-7,10,12-15H2,(H,34,40)/t18-,21+,24+/m1/s1 YPMAUZASWDWAPB-ZHRMCQFGSA-N 634869 US11814367, Compound 318 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634869&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349641 CCN(CC)c1cnn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)N[C@@H](c2ccccc2)c2ccc(C3CC3)c(F)n2)n1 InChI=1S/C28H33F2N7O2/c1-3-35(4-2)24-15-31-37(34-24)17-25(38)36-16-20(29)14-23(36)28(39)33-26(19-8-6-5-7-9-19)22-13-12-21(18-10-11-18)27(30)32-22/h5-9,12-13,15,18,20,23,26H,3-4,10-11,14,16-17H2,1-2H3,(H,33,39)/t20-,23+,26+/m1/s1 MAMGVGMAHRLJME-SEIBCYHCSA-N 634870 US11814367, Compound 319 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634870&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349642 Fc1nc(ccc1C1CC1)[C@@H](NC(=O)[C@@H]1[C@H]2C[C@H]2CN1C(=O)Cc1cnn[nH]1)c1ccccc1 634871 US11814367, Compound 320 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634871&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349643 C[C@H]1CC[C@H](N1C(=O)Cc1cnn[nH]1)C(=O)N[C@@H](c1ccccc1)c1ccc(C2CC2)c(F)n1 634872 US11814367, Compound 321 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634872&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349644 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nncc1C(F)(F)F)c1ccccc1 InChI=1S/C26H26F5N5O2/c1-15(2)19-9-8-17(10-20(19)28)24(16-6-4-3-5-7-16)33-25(38)21-11-18(27)13-35(21)23(37)14-36-22(12-32-34-36)26(29,30)31/h3-10,12,15,18,21,24H,11,13-14H2,1-2H3,(H,33,38)/t18-,21+,24+/m1/s1 NKLXYGRWDALSJM-ZHRMCQFGSA-N 634873 US11814367, Compound 322 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634873&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349645 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1CC[C@H](C)N1C(=O)Cc1cnn[nH]1)c1ccccc1 634874 US11814367, Compound 323 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634874&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349646 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H]2C[C@@H]2N1C(=O)Cc1cnn[nH]1)c1ccccc1 634875 US11814367, Compound 324 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634875&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349647 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1[C@H]2C[C@H]2CN1C(=O)Cc1cnn[nH]1)c1ccccc1 634876 US11814367, Compound 325 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634876&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349648 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn[nH]1)c1ccccc1 634877 US11814367, Compound 326 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634877&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349649 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnn[nH]1)c1ccccc1 634879 US11814367, Compound 328 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634879&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349650 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnnn1)c1ccccc1 InChI=1S/C24H26F2N6O2/c1-15(2)19-9-8-17(10-20(19)26)23(16-6-4-3-5-7-16)28-24(34)21-11-18(25)12-32(21)22(33)13-31-14-27-29-30-31/h3-10,14-15,18,21,23H,11-13H2,1-2H3,(H,28,34)/t18-,21+,23+/m1/s1 ZXDPCSQRMSZOQC-JZWVFAODSA-N 634881 US11814367, Compound 330 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634881&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349651 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccnn1)c1ccccc1 InChI=1S/C25H27F2N5O2/c1-16(2)20-9-8-18(12-21(20)27)24(17-6-4-3-5-7-17)29-25(34)22-13-19(26)14-32(22)23(33)15-31-11-10-28-30-31/h3-12,16,19,22,24H,13-15H2,1-2H3,(H,29,34)/t19-,22+,24+/m1/s1 RFZZQQMDRVUKBO-UCFCWBNQSA-N 634882 US11814367, Compound 331 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634882&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349652 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1nnc(C)o1)c1ccccc1 InChI=1S/C26H28F2N4O3/c1-15(2)20-10-9-18(11-21(20)28)25(17-7-5-4-6-8-17)29-26(34)22-12-19(27)14-32(22)24(33)13-23-31-30-16(3)35-23/h4-11,15,19,22,25H,12-14H2,1-3H3,(H,29,34)/t19-,22+,25+/m1/s1 PBHITBBSAVVVGI-WPWBMXPQSA-N 634883 US11814367, Compound 332 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634883&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349653 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C1(CC1)c1nnco1)c1ccccc1 InChI=1S/C27H28F2N4O3/c1-16(2)20-9-8-18(12-21(20)29)23(17-6-4-3-5-7-17)31-24(34)22-13-19(28)14-33(22)26(35)27(10-11-27)25-32-30-15-36-25/h3-9,12,15-16,19,22-23H,10-11,13-14H2,1-2H3,(H,31,34)/t19-,22+,23+/m1/s1 LMIQEBNXZSNDCI-OIBXWCBGSA-N 634884 US11814367, Compound 333 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634884&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349654 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)C(C)(C)c1nnco1)c1ccccc1 InChI=1S/C27H30F2N4O3/c1-16(2)20-11-10-18(12-21(20)29)23(17-8-6-5-7-9-17)31-24(34)22-13-19(28)14-33(22)26(35)27(3,4)25-32-30-15-36-25/h5-12,15-16,19,22-23H,13-14H2,1-4H3,(H,31,34)/t19-,22+,23+/m1/s1 BHSICXCLPDVSCX-OIBXWCBGSA-N 634885 US11814367, Compound 334 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634885&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349655 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnnn1C)c1ccccc1 InChI=1S/C26H29F2N5O2/c1-16(2)21-10-9-18(11-22(21)28)25(17-7-5-4-6-8-17)30-26(35)23-12-19(27)15-33(23)24(34)13-20-14-29-31-32(20)3/h4-11,14,16,19,23,25H,12-13,15H2,1-3H3,(H,30,35)/t19-,23+,25+/m1/s1 USJAVUIJAUUBLW-VPHKFGTKSA-N 634886 US11814367, Compound 335 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634886&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349656 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cn(C)nn1)c1ccccc1 InChI=1S/C26H29F2N5O2/c1-16(2)21-10-9-18(11-22(21)28)25(17-7-5-4-6-8-17)29-26(35)23-12-19(27)14-33(23)24(34)13-20-15-32(3)31-30-20/h4-11,15-16,19,23,25H,12-14H2,1-3H3,(H,29,35)/t19-,23+,25+/m1/s1 CMHRTCAGTYDYMT-VPHKFGTKSA-N 634887 US11814367, Compound 336 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634887&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349657 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccnn1C)c1ccccc1 InChI=1S/C27H30F2N4O2/c1-17(2)22-10-9-19(13-23(22)29)26(18-7-5-4-6-8-18)31-27(35)24-14-20(28)16-33(24)25(34)15-21-11-12-30-32(21)3/h4-13,17,20,24,26H,14-16H2,1-3H3,(H,31,35)/t20-,24+,26+/m1/s1 ADAFYKXFAAEJKZ-PSUQPPDWSA-N 634888 US11814367, Compound 337 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634888&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349658 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccno1)c1ccccc1 InChI=1S/C26H27F2N3O3/c1-16(2)21-9-8-18(12-22(21)28)25(17-6-4-3-5-7-17)30-26(33)23-13-19(27)15-31(23)24(32)14-20-10-11-29-34-20/h3-12,16,19,23,25H,13-15H2,1-2H3,(H,30,33)/t19-,23+,25+/m1/s1 KUCRVLBIDANTEJ-VPHKFGTKSA-N 634889 US11814367, Compound 338 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634889&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349659 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN1CC(=O)N(C)CC1=O)c1ccccc1 InChI=1S/C28H32F2N4O4/c1-17(2)21-10-9-19(11-22(21)30)27(18-7-5-4-6-8-18)31-28(38)23-12-20(29)13-34(23)26(37)16-33-15-24(35)32(3)14-25(33)36/h4-11,17,20,23,27H,12-16H2,1-3H3,(H,31,38)/t20-,23+,27+/m1/s1 QETLIEGKKPEKLD-CGHRXAFASA-N 634890 US11814367, Compound 339 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634890&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349660 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)[C@H](C)N1C(=O)Cc1cnn[nH]1)c1ccccc1 634891 US11814367, Compound 340 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634891&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349661 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccnnc1)c1ccccc1 InChI=1S/C27H28F2N4O2/c1-17(2)22-9-8-20(13-23(22)29)26(19-6-4-3-5-7-19)32-27(35)24-14-21(28)16-33(24)25(34)12-18-10-11-30-31-15-18/h3-11,13,15,17,21,24,26H,12,14,16H2,1-2H3,(H,32,35)/t21-,24+,26+/m1/s1 BYSHVVHKIMUGDQ-DSBYRVASSA-N 634893 US11814367, Compound 342 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634893&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349662 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cccnn1)c1ccccc1 InChI=1S/C27H28F2N4O2/c1-17(2)22-11-10-19(13-23(22)29)26(18-7-4-3-5-8-18)31-27(35)24-14-20(28)16-33(24)25(34)15-21-9-6-12-30-32-21/h3-13,17,20,24,26H,14-16H2,1-2H3,(H,31,35)/t20-,24+,26+/m1/s1 LQDWSTOPZFBLCW-PSUQPPDWSA-N 634894 US11814367, Compound 343 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634894&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349663 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnccn1)c1ccccc1 InChI=1S/C27H28F2N4O2/c1-17(2)22-9-8-19(12-23(22)29)26(18-6-4-3-5-7-18)32-27(35)24-13-20(28)16-33(24)25(34)14-21-15-30-10-11-31-21/h3-12,15,17,20,24,26H,13-14,16H2,1-2H3,(H,32,35)/t20-,24+,26+/m1/s1 CSMTVBITIAVKAP-PSUQPPDWSA-N 634895 US11814367, Compound 344 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634895&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349664 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cncnc1)c1ccccc1 InChI=1S/C27H28F2N4O2/c1-17(2)22-9-8-20(11-23(22)29)26(19-6-4-3-5-7-19)32-27(35)24-12-21(28)15-33(24)25(34)10-18-13-30-16-31-14-18/h3-9,11,13-14,16-17,21,24,26H,10,12,15H2,1-2H3,(H,32,35)/t21-,24+,26+/m1/s1 YICZTINJWHEXRP-DSBYRVASSA-N 634896 US11814367, Compound 345 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634896&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349665 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccncn1)c1ccccc1 InChI=1S/C27H28F2N4O2/c1-17(2)22-9-8-19(12-23(22)29)26(18-6-4-3-5-7-18)32-27(35)24-13-20(28)15-33(24)25(34)14-21-10-11-30-16-31-21/h3-12,16-17,20,24,26H,13-15H2,1-2H3,(H,32,35)/t20-,24+,26+/m1/s1 MJOWLOOWSMWSAC-PSUQPPDWSA-N 634897 US11814367, Compound 346 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634897&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349666 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccncc1)c1ccccc1 InChI=1S/C28H29F2N3O2/c1-18(2)23-9-8-21(15-24(23)30)27(20-6-4-3-5-7-20)32-28(35)25-16-22(29)17-33(25)26(34)14-19-10-12-31-13-11-19/h3-13,15,18,22,25,27H,14,16-17H2,1-2H3,(H,32,35)/t22-,25+,27+/m1/s1 OCTQTALXHASOFO-PWMMPXSUSA-N 634898 US11814367, Compound 347 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634898&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349667 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cccnc1)c1ccccc1 InChI=1S/C28H29F2N3O2/c1-18(2)23-11-10-21(14-24(23)30)27(20-8-4-3-5-9-20)32-28(35)25-15-22(29)17-33(25)26(34)13-19-7-6-12-31-16-19/h3-12,14,16,18,22,25,27H,13,15,17H2,1-2H3,(H,32,35)/t22-,25+,27+/m1/s1 UNZSQLUOSDDPIV-PWMMPXSUSA-N 634899 US11814367, Compound 348 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634899&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349668 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccccn1)c1ccccc1 InChI=1S/C28H29F2N3O2/c1-18(2)23-12-11-20(14-24(23)30)27(19-8-4-3-5-9-19)32-28(35)25-15-21(29)17-33(25)26(34)16-22-10-6-7-13-31-22/h3-14,18,21,25,27H,15-17H2,1-2H3,(H,32,35)/t21-,25+,27+/m1/s1 NAJPICQRDJLXCX-UDZXTKBFSA-N 634900 US11814367, Compound 349 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634900&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349669 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccn(C)n1)c1ccccc1 InChI=1S/C27H30F2N4O2/c1-17(2)22-10-9-19(13-23(22)29)26(18-7-5-4-6-8-18)30-27(35)24-14-20(28)16-33(24)25(34)15-21-11-12-32(3)31-21/h4-13,17,20,24,26H,14-16H2,1-3H3,(H,30,35)/t20-,24+,26+/m1/s1 RBJZBOAVLAYPCM-PSUQPPDWSA-N 634901 US11814367, Compound 350 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634901&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349670 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1c(C)nn(C)c1C)c1ccccc1 InChI=1S/C29H34F2N4O2/c1-17(2)23-12-11-21(13-25(23)31)28(20-9-7-6-8-10-20)32-29(37)26-14-22(30)16-35(26)27(36)15-24-18(3)33-34(5)19(24)4/h6-13,17,22,26,28H,14-16H2,1-5H3,(H,32,37)/t22-,26+,28+/m1/s1 UQQRSEFQROLYAY-ZEZZXZOMSA-N 634902 US11814367, Compound 351 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634902&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349671 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C)c(=O)[nH]c1=O)c1ccccc1 634903 US11814367, Compound 352 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634903&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349672 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C)c(=O)n(C)c1=O)c1ccccc1 InChI=1S/C29H32F2N4O4/c1-17(2)22-11-10-20(12-23(22)31)26(19-8-6-5-7-9-19)32-27(37)24-13-21(30)15-35(24)25(36)16-34-14-18(3)28(38)33(4)29(34)39/h5-12,14,17,21,24,26H,13,15-16H2,1-4H3,(H,32,37)/t21-,24+,26+/m1/s1 QHHQVKWFGTVKQC-DSBYRVASSA-N 634904 US11814367, Compound 353 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634904&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349673 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cnc2ccccc12)c1ccccc1 InChI=1S/C30H30F2N4O2/c1-19(2)23-13-12-21(14-24(23)32)29(20-8-4-3-5-9-20)34-30(38)27-15-22(31)16-36(27)28(37)17-35-18-33-25-10-6-7-11-26(25)35/h3-14,18-19,22,27,29H,15-17H2,1-2H3,(H,34,38)/t22-,27+,29+/m1/s1 AJYAGZCYBYATIT-RVBRUHEGSA-N 634905 US11814367, Compound 354 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634905&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349674 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnn(C)c1)c1ccccc1 InChI=1S/C27H30F2N4O2/c1-17(2)22-10-9-20(12-23(22)29)26(19-7-5-4-6-8-19)31-27(35)24-13-21(28)16-33(24)25(34)11-18-14-30-32(3)15-18/h4-10,12,14-15,17,21,24,26H,11,13,16H2,1-3H3,(H,31,35)/t21-,24+,26+/m1/s1 VAHLTZMFIMRCMG-DSBYRVASSA-N 634906 US11814367, Compound 355 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634906&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349675 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cnc2ccccn12)c1ccccc1 InChI=1S/C30H30F2N4O2/c1-19(2)24-12-11-21(14-25(24)32)29(20-8-4-3-5-9-20)34-30(38)26-15-22(31)18-36(26)28(37)16-23-17-33-27-10-6-7-13-35(23)27/h3-14,17,19,22,26,29H,15-16,18H2,1-2H3,(H,34,38)/t22-,26+,29+/m1/s1 JAAQYGAYIBMICL-DVTKYRPYSA-N 634907 US11814367, Compound 356 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634907 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634907&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349676 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccc2ncccc2c1)c1ccccc1 InChI=1S/C32H31F2N3O2/c1-20(2)26-12-11-24(17-27(26)34)31(22-7-4-3-5-8-22)36-32(39)29-18-25(33)19-37(29)30(38)16-21-10-13-28-23(15-21)9-6-14-35-28/h3-15,17,20,25,29,31H,16,18-19H2,1-2H3,(H,36,39)/t25-,29+,31+/m1/s1 ZROIRUGAUUEWNL-IDTFQEBLSA-N 634908 US11814367, Compound 357 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634908 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634908&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349677 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1ccc2ncnn2c1)c1ccccc1 InChI=1S/C29H29F2N5O2/c1-18(2)23-10-9-21(13-24(23)31)28(20-6-4-3-5-7-20)34-29(38)25-14-22(30)16-35(25)27(37)12-19-8-11-26-32-17-33-36(26)15-19/h3-11,13,15,17-18,22,25,28H,12,14,16H2,1-2H3,(H,34,38)/t22-,25+,28+/m1/s1 BZRHIRLGHCYCFZ-ATILKMQGSA-N 634909 US11814367, Compound 358 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634909 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634909&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349678 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nnnc1C(F)(F)F)c1ccccc1 InChI=1S/C25H25F5N6O2/c1-14(2)18-9-8-16(10-19(18)27)22(15-6-4-3-5-7-15)31-23(38)20-11-17(26)12-35(20)21(37)13-36-24(25(28,29)30)32-33-34-36/h3-10,14,17,20,22H,11-13H2,1-2H3,(H,31,38)/t17-,20+,22+/m1/s1 AZUSJXJPXHZNEM-AGHHOFFYSA-N 634910 US11814367, Compound 359 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634910&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349679 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)COC(=O)N(C)C)c1ccccc1 InChI=1S/C26H31F2N3O4/c1-16(2)20-11-10-18(12-21(20)28)24(17-8-6-5-7-9-17)29-25(33)22-13-19(27)14-31(22)23(32)15-35-26(34)30(3)4/h5-12,16,19,22,24H,13-15H2,1-4H3,(H,29,33)/t19-,22+,24+/m1/s1 MVYSLEQUCWOEON-UCFCWBNQSA-N 634911 US11814367, Compound 360 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634911 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634911&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349680 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N(C)C)c1ccccc1 InChI=1S/C26H32F2N4O3/c1-16(2)20-11-10-18(12-21(20)28)24(17-8-6-5-7-9-17)30-25(34)22-13-19(27)15-32(22)23(33)14-29-26(35)31(3)4/h5-12,16,19,22,24H,13-15H2,1-4H3,(H,29,35)(H,30,34)/t19-,22+,24+/m1/s1 LDDXOTPIMMAFNT-UCFCWBNQSA-N 634912 US11814367, Compound 361 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634912&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349681 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CN(C)C(=O)N(C)C)c1ccccc1 InChI=1S/C27H34F2N4O3/c1-17(2)21-12-11-19(13-22(21)29)25(18-9-7-6-8-10-18)30-26(35)23-14-20(28)15-33(23)24(34)16-32(5)27(36)31(3)4/h6-13,17,20,23,25H,14-16H2,1-5H3,(H,30,35)/t20-,23+,25+/m1/s1 RLLWDGWRYXFJCT-PBXXJUDPSA-N 634913 US11814367, Compound 362 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634913&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349682 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)COC(=O)N1CCNCC1)c1ccccc1 InChI=1S/C28H34F2N4O4/c1-18(2)22-9-8-20(14-23(22)30)26(19-6-4-3-5-7-19)32-27(36)24-15-21(29)16-34(24)25(35)17-38-28(37)33-12-10-31-11-13-33/h3-9,14,18,21,24,26,31H,10-13,15-17H2,1-2H3,(H,32,36)/t21-,24+,26+/m1/s1 BURSJTCFXAGZBS-DSBYRVASSA-N 634914 US11814367, Compound 363 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634914&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349683 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)COC(=O)N1CCN(CC1)C(=O)OC(C)(C)C)c1ccccc1 InChI=1S/C33H42F2N4O6/c1-21(2)25-12-11-23(17-26(25)35)29(22-9-7-6-8-10-22)36-30(41)27-18-24(34)19-39(27)28(40)20-44-31(42)37-13-15-38(16-14-37)32(43)45-33(3,4)5/h6-12,17,21,24,27,29H,13-16,18-20H2,1-5H3,(H,36,41)/t24-,27+,29+/m1/s1 KAKAITAWHVCJPT-QXGAZULMSA-N 634915 US11814367, Compound 364 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634915 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634915&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349684 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CCNCC1)c1ccccc1 InChI=1S/C28H35F2N5O3/c1-18(2)22-9-8-20(14-23(22)30)26(19-6-4-3-5-7-19)33-27(37)24-15-21(29)17-35(24)25(36)16-32-28(38)34-12-10-31-11-13-34/h3-9,14,18,21,24,26,31H,10-13,15-17H2,1-2H3,(H,32,38)(H,33,37)/t21-,24+,26+/m1/s1 YSBXNEURXKYECH-DSBYRVASSA-N 634916 US11814367, Compound 365 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634916&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349685 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)CNC(=O)N1CCN(CC1)C(=O)OC(C)(C)C)c1ccccc1 InChI=1S/C33H43F2N5O5/c1-21(2)25-12-11-23(17-26(25)35)29(22-9-7-6-8-10-22)37-30(42)27-18-24(34)20-40(27)28(41)19-36-31(43)38-13-15-39(16-14-38)32(44)45-33(3,4)5/h6-12,17,21,24,27,29H,13-16,18-20H2,1-5H3,(H,36,43)(H,37,42)/t24-,27+,29+/m1/s1 BXHMYRBRMJCTAU-QXGAZULMSA-N 634917 US11814367, Compound 366 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634917&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349686 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1[nH]nnc1C)c1ccccc1 634918 US11814367, Compound 367 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634918&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349687 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1[nH]nnc1C(F)(F)F)c1ccccc1 634919 US11814367, Compound 368 Glycogen [starch] synthase, liver >82290 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634919&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349688 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1[nH]nnc1N1CCNCC1)c1ccccc1 634920 US11814367, Compound 369 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634920&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349689 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1[nH]nnc1N1CCOCC1)c1ccccc1 634922 US11814367, Compound 371 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634922&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349690 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(nn1)C(F)(F)F)c1ccccc1 InChI=1S/C26H26F5N5O2/c1-15(2)19-9-8-17(10-20(19)28)24(16-6-4-3-5-7-16)32-25(38)21-11-18(27)12-36(21)23(37)14-35-13-22(33-34-35)26(29,30)31/h3-10,13,15,18,21,24H,11-12,14H2,1-2H3,(H,32,38)/t18-,21+,24+/m1/s1 SPZQAIFEPSGIPV-ZHRMCQFGSA-N 634923 US11814367, Compound 372 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634923&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349691 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(C)nn1)c1ccccc1 InChI=1S/C26H29F2N5O2/c1-16(2)21-10-9-19(11-22(21)28)25(18-7-5-4-6-8-18)29-26(35)23-12-20(27)14-33(23)24(34)15-32-13-17(3)30-31-32/h4-11,13,16,20,23,25H,12,14-15H2,1-3H3,(H,29,35)/t20-,23+,25+/m1/s1 MIDNXZOXDIECFU-PBXXJUDPSA-N 634924 US11814367, Compound 373 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634924&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349692 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1nncc1C)c1ccccc1 InChI=1S/C26H29F2N5O2/c1-16(2)21-10-9-19(11-22(21)28)25(18-7-5-4-6-8-18)30-26(35)23-12-20(27)14-32(23)24(34)15-33-17(3)13-29-31-33/h4-11,13,16,20,23,25H,12,14-15H2,1-3H3,(H,30,35)/t20-,23+,25+/m1/s1 OINAEQOBOQZNCM-PBXXJUDPSA-N 634925 US11814367, Compound 374 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634925&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349693 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(nn1)N1CCNCC1)c1ccccc1 InChI=1S/C29H35F2N7O2/c1-19(2)23-9-8-21(14-24(23)31)28(20-6-4-3-5-7-20)33-29(40)25-15-22(30)16-38(25)27(39)18-37-17-26(34-35-37)36-12-10-32-11-13-36/h3-9,14,17,19,22,25,28,32H,10-13,15-16,18H2,1-2H3,(H,33,40)/t22-,25+,28+/m1/s1 VNEWALJZMYTWJX-ATILKMQGSA-N 634926 US11814367, Compound 375 Glycogen [starch] synthase, liver >77430 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634926&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349694 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ncc(n1)N1CCNCC1)c1ccccc1 InChI=1S/C29H35F2N7O2/c1-19(2)23-9-8-21(14-24(23)31)28(20-6-4-3-5-7-20)34-29(40)25-15-22(30)17-37(25)27(39)18-38-33-16-26(35-38)36-12-10-32-11-13-36/h3-9,14,16,19,22,25,28,32H,10-13,15,17-18H2,1-2H3,(H,34,40)/t22-,25+,28+/m1/s1 YNFHEKZBZLPSMN-ATILKMQGSA-N 634927 US11814367, Compound 376 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634927&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349695 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1cc(nn1)N(C)C)c1ccccc1 InChI=1S/C27H32F2N6O2/c1-17(2)21-11-10-19(12-22(21)29)26(18-8-6-5-7-9-18)30-27(37)23-13-20(28)14-35(23)25(36)16-34-15-24(31-32-34)33(3)4/h5-12,15,17,20,23,26H,13-14,16H2,1-4H3,(H,30,37)/t20-,23+,26+/m1/s1 DFEPVXLMBBSWQA-SEIBCYHCSA-N 634928 US11814367, Compound 377 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634928&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349696 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ncc(n1)N(C)C)c1ccccc1 InChI=1S/C27H32F2N6O2/c1-17(2)21-11-10-19(12-22(21)29)26(18-8-6-5-7-9-18)31-27(37)23-13-20(28)15-34(23)25(36)16-35-30-14-24(32-35)33(3)4/h5-12,14,17,20,23,26H,13,15-16H2,1-4H3,(H,31,37)/t20-,23+,26+/m1/s1 VXSNWFYFAAKWBK-SEIBCYHCSA-N 634929 US11814367, Compound 378 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634929&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349697 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cc1cccn2c1n[nH]c2=O)c1ccccc1 634930 US11814367, Compound 379 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634930&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349698 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)Cn1ccnc1)c1ccccc1 InChI=1S/C26H28F2N4O2/c1-17(2)21-9-8-19(12-22(21)28)25(18-6-4-3-5-7-18)30-26(34)23-13-20(27)14-32(23)24(33)15-31-11-10-29-16-31/h3-12,16-17,20,23,25H,13-15H2,1-2H3,(H,30,34)/t20-,23+,25+/m1/s1 PZKZHICKWQAAGF-PBXXJUDPSA-N 634931 US11814367, Compound 380 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634931&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349699 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@@H]1CNC(=O)O1)c1ccccc1 InChI=1S/C25H27F2N3O4/c1-14(2)18-9-8-16(10-19(18)27)22(15-6-4-3-5-7-15)29-23(31)20-11-17(26)13-30(20)24(32)21-12-28-25(33)34-21/h3-10,14,17,20-22H,11-13H2,1-2H3,(H,28,33)(H,29,31)/t17-,20+,21+,22+/m1/s1 IHZDWYKSRLNKHI-MNAPGUCWSA-N 634932 US11814367, Compound 381 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634932 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634932&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8 1349700 CC(C)c1ccc(cc1F)[C@@H](NC(=O)[C@@H]1C[C@@H](F)CN1C(=O)[C@H]1CNC(=O)O1)c1ccccc1 InChI=1S/C25H27F2N3O4/c1-14(2)18-9-8-16(10-19(18)27)22(15-6-4-3-5-7-15)29-23(31)20-11-17(26)13-30(20)24(32)21-12-28-25(33)34-21/h3-10,14,17,20-22H,11-13H2,1-2H3,(H,28,33)(H,29,31)/t17-,20+,21-,22+/m1/s1 IHZDWYKSRLNKHI-YCZSINBZSA-N 634933 US11814367, Compound 382 Glycogen [starch] synthase, liver >100000 US Patent 10.7270/Q2Z60T60 US11814367 Morgans, Jr., DJ; Mellem, K; Powers, HL; Lee, PS; Won, W; Sinz, CJ Maze Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=634933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000701&target=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=634933&enzyme=Glycogen+%5Bstarch%5D+synthase%2C+liver&column=ki&startPg=0&Increment=50&submit=Search 1 MLRGRSLSVTSLGGLPQWEVEELPVEELLLFEVAWEVTNKVGGIYTVIQTKAKTTADEWGENYFLIGPYFEHNMKTQVEQCEPVNDAVRRAVDAMNKHGCQVHFGRWLIEGSPYVVLFDIGYSAWNLDRWKGDLWEACSVGIPYHDREANDMLIFGSLTAWFLKEVTDHADGKYVVAQFHEWQAGIGLILSRARKLPIATIFTTHATLLGRYLCAANIDFYNHLDKFNIDKEAGERQIYHRYCMERASVHCAHVFTTVSEITAIEAEHMLKRKPDVVTPNGLNVKKFSAVHEFQNLHAMYKARIQDFVRGHFYGHLDFDLEKTLFLFIAGRYEFSNKGADIFLESLSRLNFLLRMHKSDITVMVFFIMPAKTNNFNVETLKGQAVRKQLWDVAHSVKEKFGKKLYDALLRGEIPDLNDILDRDDLTIMKRAIFSTQRQSLPPVTTHNMIDDSTDPILSTIRRIGLFNNRTDRVKVILHPEFLSSTSPLLPMDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSVTTNLSGFGCFMQEHVADPTAYGIYIVDRRFRSPDDSCNQLTKFLYGFCKQSRRQRIIQRNRTERLSDLLDWRYLGRYYQHARHLTLSRAFPDKFHVELTSPPTTEGFKYPRPSSVPPSPSGSQASSPQSSDVEDEVEDERYDEEEEAERDRLNIKSPFSLSHVPHGKKKLHGEYKN Glycogen [starch] synthase, liver GYS2_HUMAN P54840 A0AVD8