BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50174433 OC(=O)c1cc(nc2ccc(I)cc12)-c1ccc(Br)cc1 InChI=1S/C16H9BrINO2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,(H,20,21) CLZXCWTYHJAVPT-UHFFFAOYSA-N 50097082 2-(4-Bromo-phenyl)-6-iodo-quinoline-4-carboxylic acid::CHEMBL357572 Proline--tRNA ligase, cytoplasmic Candida albicans 19 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097082 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097082&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 1016084 103994476 CHEMBL357572 ZINC08443064 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174435 Cc1cc(Cl)cc2nc(cc(C(O)=O)c12)-c1ccc(Br)cc1 InChI=1S/C17H11BrClNO2/c1-9-6-12(19)7-15-16(9)13(17(21)22)8-14(20-15)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) GLZCFQBZWMFBMI-UHFFFAOYSA-N 50097084 2-(4-Bromo-phenyl)-7-chloro-5-methyl-quinoline-4-carboxylic acid::CHEMBL151769 Proline--tRNA ligase, cytoplasmic Candida albicans 1500 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097084&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275527 103994478 CHEMBL151769 ZINC27620096 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174439 OC(=O)\C=C\c1ccc2nc(cc(C(O)=O)c2c1)-c1ccc(Br)cc1 InChI=1S/C19H12BrNO4/c20-13-5-3-12(4-6-13)17-10-15(19(24)25)14-9-11(2-8-18(22)23)1-7-16(14)21-17/h1-10H,(H,22,23)(H,24,25)/b8-2+ OQYGDBLJHDKCPQ-KRXBUXKQSA-N 50097087 2-(4-Bromo-phenyl)-6-((E)-2-carboxy-vinyl)-quinoline-4-carboxylic acid::CHEMBL150306 Proline--tRNA ligase, cytoplasmic Candida albicans 1300 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097087&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275525 103994481 CHEMBL150306 ZINC27628106 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174441 OC(=O)c1cc(nc2ccc(Cl)cc12)-c1ccc(Br)cc1 InChI=1S/C16H9BrClNO2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,(H,20,21) LCUJVPKQAPUUAQ-UHFFFAOYSA-N 50097090 2-(4-Bromo-phenyl)-6-chloro-quinoline-4-carboxylic acid::CHEMBL153238 Proline--tRNA ligase, cytoplasmic Candida albicans 26 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097090&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 1038445 103994484 CHEMBL153238 ZINC00709344 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174442 OC(=O)c1cc(nc2ccccc12)-c1ccco1 InChI=1S/C14H9NO3/c16-14(17)10-8-12(13-6-3-7-18-13)15-11-5-2-1-4-9(10)11/h1-8H,(H,16,17) WWEKTFINADFAEC-UHFFFAOYSA-N 35453 2-(2-furanyl)-4-quinolinecarboxylic acid::2-(2-furyl)cinchoninic acid::2-(furan-2-yl)quinoline-4-carboxylic acid::2-Furan-2-yl-quinoline-4-carboxylic acid::CC-PMLSC-DMA-P117::CHEMBL150924::cid_697640 Proline--tRNA ligase, cytoplasmic Candida albicans >100000 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35453&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 697640 252617718 CHEMBL150924 ZINC00074195 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174443 OC(=O)c1cc(nc2ccccc12)-c1ccc(Cl)c(Cl)c1 InChI=1S/C16H9Cl2NO2/c17-12-6-5-9(7-13(12)18)15-8-11(16(20)21)10-3-1-2-4-14(10)19-15/h1-8H,(H,20,21) METUEFNOMUIMQR-UHFFFAOYSA-N 50097083 2-(3,4-Dichloro-phenyl)-quinoline-4-carboxylic acid::CHEMBL150249 Proline--tRNA ligase, cytoplasmic Candida albicans 19000 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097083&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 695258 103994477 CHEMBL150249 ZINC00069324 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174445 OC(=O)c1cc(nc2cc(Cl)cc(Cl)c12)-c1ccc(Br)cc1 InChI=1S/C16H8BrCl2NO2/c17-9-3-1-8(2-4-9)13-7-11(16(21)22)15-12(19)5-10(18)6-14(15)20-13/h1-7H,(H,21,22) HQKJAPNOOSHIBL-UHFFFAOYSA-N 50097091 2-(4-Bromo-phenyl)-5,7-dichloro-quinoline-4-carboxylic acid::CHEMBL358675 Proline--tRNA ligase, cytoplasmic Candida albicans 140 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097091&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275530 103994485 CHEMBL358675 ZINC27620879 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174450 Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)Oc1nnn[nH]1 InChI=1S/C18H11BrClN5O2/c1-9-6-12(20)7-13-14(17(26)27-18-22-24-25-23-18)8-15(21-16(9)13)10-2-4-11(19)5-3-10/h2-8H,1H3,(H,22,23,24,25) FFBGLVSIBIKUOL-UHFFFAOYSA-N 50097086 2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-carboxylic acid 1H-tetrazol-5-yl ester::CHEMBL151039 Proline--tRNA ligase, cytoplasmic Candida albicans 30 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097086&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44367066 103994480 CHEMBL151039 ZINC27622289 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174451 Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(O)=O InChI=1S/C17H11BrClNO2/c1-9-6-12(19)7-13-14(17(21)22)8-15(20-16(9)13)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) TZOKMWXGAXPQIM-UHFFFAOYSA-N 50097096 2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-carboxylic acid::CHEMBL357355 Proline--tRNA ligase, cytoplasmic Candida albicans 5 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097096&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 487529 103994490 CHEMBL357355 ZINC01490481 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174453 OC(=O)c1cc(nc2ccccc12)-c1ccc(Br)cc1 InChI=1S/C16H10BrNO2/c17-11-7-5-10(6-8-11)15-9-13(16(19)20)12-3-1-2-4-14(12)18-15/h1-9H,(H,19,20) JEUYPXDMAWIMOG-UHFFFAOYSA-N 50097094 2-(4-Bromo-phenyl)-quinoline-4-carboxylic acid::CHEMBL440534 Proline--tRNA ligase, cytoplasmic Candida albicans 500 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097094&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 230595 103994488 CHEMBL440534 ZINC00035846 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174454 Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)OCc1ccc(Cl)c(Cl)c1 InChI=1S/C24H15BrCl3NO2/c1-13-8-17(26)10-18-19(24(30)31-12-14-2-7-20(27)21(28)9-14)11-22(29-23(13)18)15-3-5-16(25)6-4-15/h2-11H,12H2,1H3 VNPWROBHJGLIMQ-UHFFFAOYSA-N 50097095 2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-carboxylic acid 3,4-dichloro-benzyl ester::CHEMBL345331 Proline--tRNA ligase, cytoplasmic Candida albicans 20 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097095&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275537 103994489 CHEMBL345331 ZINC27631290 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174456 OC(=O)c1cc(nc2ccccc12)-c1ccc(Cl)s1 InChI=1S/C14H8ClNO2S/c15-13-6-5-12(19-13)11-7-9(14(17)18)8-3-1-2-4-10(8)16-11/h1-7H,(H,17,18) GNBCDNSGZAPUEF-UHFFFAOYSA-N 50097098 2-(5-Chloro-thiophen-2-yl)-quinoline-4-carboxylic acid::CHEMBL153072::cid_625773 Proline--tRNA ligase, cytoplasmic Candida albicans 32000 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097098&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 625773 103994492 CHEMBL153072 ZINC00035849 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174459 OC(=O)c1cc(nc2ccccc12)-c1ccccc1 InChI=1S/C16H11NO2/c18-16(19)13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,(H,18,19) YTRMTPPVNRALON-UHFFFAOYSA-N 50097100 2-Phenyl-quinoline-4-carboxylic acid::2-phenylquinoline-4-carboxylic acid::CHEMBL348000::Cinchophen Proline--tRNA ligase, cytoplasmic Candida albicans >100000 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097100&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 8593 103994494 CHEMBL348000 ZINC00125047 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174461 OC(=O)c1cc(nc2ccccc12)-c1ccc2ccccc2c1 InChI=1S/C20H13NO2/c22-20(23)17-12-19(21-18-8-4-3-7-16(17)18)15-10-9-13-5-1-2-6-14(13)11-15/h1-12H,(H,22,23) LLMCWSJMTWWINZ-UHFFFAOYSA-N 50097101 2-Naphthalen-2-yl-quinoline-4-carboxylic acid::CHEMBL345300 Proline--tRNA ligase, cytoplasmic Candida albicans 3600 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097101&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 680333 103994495 CHEMBL345300 ZINC00044904 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174463 Cc1cc(C)c2nc(cc(C(O)=O)c2c1)-c1ccc(Br)cc1 InChI=1S/C18H14BrNO2/c1-10-7-11(2)17-14(8-10)15(18(21)22)9-16(20-17)12-3-5-13(19)6-4-12/h3-9H,1-2H3,(H,21,22) GBORHFHYPAQPQQ-UHFFFAOYSA-N 50097088 2-(4-Bromo-phenyl)-6,8-dimethyl-quinoline-4-carboxylic acid::CHEMBL150993 Proline--tRNA ligase, cytoplasmic Candida albicans 25000 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097088&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 997453 103994482 CHEMBL150993 ZINC04651885 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174465 Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)OCc1ccco1 InChI=1S/C22H15BrClNO3/c1-13-9-16(24)10-18-19(22(26)28-12-17-3-2-8-27-17)11-20(25-21(13)18)14-4-6-15(23)7-5-14/h2-11H,12H2,1H3 FFOCYOZUAILUNQ-UHFFFAOYSA-N 50097102 2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-carboxylic acid furan-2-ylmethyl ester::CHEMBL150266 Proline--tRNA ligase, cytoplasmic Candida albicans 70.0 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097102&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275538 103994496 CHEMBL150266 ZINC27622215 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174468 OC(=O)c1cc(nc2ccccc12)-c1ccncc1 InChI=1S/C15H10N2O2/c18-15(19)12-9-14(10-5-7-16-8-6-10)17-13-4-2-1-3-11(12)13/h1-9H,(H,18,19) IBXRRNLSWGROLA-UHFFFAOYSA-N 50097097 2-Pyridin-4-yl-quinoline-4-carboxylic acid::CHEMBL415737 Proline--tRNA ligase, cytoplasmic Candida albicans >100000 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097097&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 26587 103994491 CHEMBL415737 ZINC00065268 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174470 Nc1ccc2nc(cc(C(O)=O)c2c1)-c1ccc(Br)cc1 InChI=1S/C16H11BrN2O2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,18H2,(H,20,21) MQSHNAJWQYMTOJ-UHFFFAOYSA-N 50097099 6-Amino-2-(4-bromo-phenyl)-quinoline-4-carboxylic acid::CHEMBL356452 Proline--tRNA ligase, cytoplasmic Candida albicans 3300 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097099&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275524 103994493 CHEMBL356452 ZINC27632690 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174473 Cc1cc(Cl)c2nc(cc(C(O)=O)c2c1)-c1ccc(Br)cc1 InChI=1S/C17H11BrClNO2/c1-9-6-12-13(17(21)22)8-15(20-16(12)14(19)7-9)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) DGNPBMMKWKJHTC-UHFFFAOYSA-N 50097106 2-(4-Bromo-phenyl)-8-chloro-6-methyl-quinoline-4-carboxylic acid::CHEMBL150488 Proline--tRNA ligase, cytoplasmic Candida albicans 25 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097106&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275528 103994500 CHEMBL150488 ZINC27624555 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174475 OC(=O)c1cc(nc2ccc(cc12)S(O)(=O)=O)-c1ccc(Br)cc1 InChI=1S/C16H10BrNO5S/c17-10-3-1-9(2-4-10)15-8-13(16(19)20)12-7-11(24(21,22)23)5-6-14(12)18-15/h1-8H,(H,19,20)(H,21,22,23) UBLBOXFCHGYNRT-UHFFFAOYSA-N 50097085 2-(4-Bromo-phenyl)-6-sulfo-quinoline-4-carboxylic acid::CHEMBL153066 Proline--tRNA ligase, cytoplasmic Candida albicans 15000 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097085&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44367351 103994479 CHEMBL153066 ZINC27631171 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174477 Cc1c(F)ccc2c(cc(nc12)-c1ccc(Br)cc1)C(O)=O InChI=1S/C17H11BrFNO2/c1-9-14(19)7-6-12-13(17(21)22)8-15(20-16(9)12)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) QJUZISYXDUDJQC-UHFFFAOYSA-N 50097107 2-(4-Bromo-phenyl)-7-fluoro-8-methyl-quinoline-4-carboxylic acid::CHEMBL346646 Proline--tRNA ligase, cytoplasmic Candida albicans 120 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097107&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275533 103994501 CHEMBL346646 ZINC27619176 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174479 OC(=O)c1cc(nc2ccc(cc12)-c1ccc(O)cc1)-c1ccc(Br)cc1 InChI=1S/C22H14BrNO3/c23-16-6-1-14(2-7-16)21-12-19(22(26)27)18-11-15(5-10-20(18)24-21)13-3-8-17(25)9-4-13/h1-12,25H,(H,26,27) RPWZLVCFUYJNGM-UHFFFAOYSA-N 50097103 2-(4-Bromo-phenyl)-6-(4-hydroxy-phenyl)-quinoline-4-carboxylic acid::CHEMBL150896 Proline--tRNA ligase, cytoplasmic Candida albicans 350 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097103&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275526 103994497 CHEMBL150896 ZINC27629155 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174481 Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)OCc1ccc(cc1)-c1ccccc1 InChI=1S/C30H21BrClNO2/c1-19-15-25(32)16-26-27(17-28(33-29(19)26)23-11-13-24(31)14-12-23)30(34)35-18-20-7-9-22(10-8-20)21-5-3-2-4-6-21/h2-17H,18H2,1H3 NJLFIHLPSYNLGF-UHFFFAOYSA-N 50097108 2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-carboxylic acid biphenyl-4-ylmethyl ester::CHEMBL153564 Proline--tRNA ligase, cytoplasmic Candida albicans 8800.0 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097108&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275536 103994502 CHEMBL153564 ZINC27631296 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174482 OC(=O)c1cc(nc2ccc(Br)cc12)-c1ccc(Br)cc1 InChI=1S/C16H9Br2NO2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,(H,20,21) JTOIYLWKTKYNBG-UHFFFAOYSA-N 50097105 6-Bromo-2-(4-bromo-phenyl)-quinoline-4-carboxylic acid::CHEMBL153347 Proline--tRNA ligase, cytoplasmic Candida albicans 25 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097105&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 1223599 103994499 CHEMBL153347 ZINC00999583 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174483 Cc1cc(Cl)cc2c(COS(N)(=O)=O)cc(nc12)-c1ccc(Br)cc1 InChI=1S/C17H14BrClN2O3S/c1-10-6-14(19)8-15-12(9-24-25(20,22)23)7-16(21-17(10)15)11-2-4-13(18)5-3-11/h2-8H,9H2,1H3,(H2,20,22,23) DRDAWQHWJPWHAN-UHFFFAOYSA-N 50097111 CHEMBL150305::Sulfamic acid 2-(4-bromo-phenyl)-6-chloro-8-methyl-quinolin-4-ylmethyl ester Proline--tRNA ligase, cytoplasmic Candida albicans 2400 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097111&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275534 103994505 CHEMBL150305 ZINC27628100 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174485 Cc1c(Br)ccc2c(cc(nc12)-c1ccc(Br)cc1)C(O)=O InChI=1S/C17H11Br2NO2/c1-9-14(19)7-6-12-13(17(21)22)8-15(20-16(9)12)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) JTYPFFVADGWNGS-UHFFFAOYSA-N 50097093 7-Bromo-2-(4-bromo-phenyl)-8-methyl-quinoline-4-carboxylic acid::CHEMBL348184 Proline--tRNA ligase, cytoplasmic Candida albicans 150 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097093&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275532 103994487 CHEMBL348184 ZINC27621212 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174486 COC(=O)C(Cc1ccccc1)NC(=O)c1cc(nc2c(C)cc(Cl)cc12)-c1ccc(Br)cc1 InChI=1S/C27H22BrClN2O3/c1-16-12-20(29)14-21-22(15-23(30-25(16)21)18-8-10-19(28)11-9-18)26(32)31-24(27(33)34-2)13-17-6-4-3-5-7-17/h3-12,14-15,24H,13H2,1-2H3,(H,31,32) GPPJAYKTCZLBKF-UHFFFAOYSA-N 50097092 2-{[2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-carbonyl]-amino}-3-phenyl-propionic acid methyl ester::CHEMBL434852 Proline--tRNA ligase, cytoplasmic Candida albicans 5700 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097092&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275535 103994486 CHEMBL434852 ZINC27631309 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174487 OC(=O)c1cc(nc2ccccc12)-c1ccc(cc1)C(F)(F)F InChI=1S/C17H10F3NO2/c18-17(19,20)11-7-5-10(6-8-11)15-9-13(16(22)23)12-3-1-2-4-14(12)21-15/h1-9H,(H,22,23) DYBCZSIHZLWHTQ-UHFFFAOYSA-N 50097110 2-(4-Trifluoromethyl-phenyl)-quinoline-4-carboxylic acid::CHEMBL151890 Proline--tRNA ligase, cytoplasmic Candida albicans >100000 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097110&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 4038525 103994504 CHEMBL151890 ZINC03757850 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174489 COc1ccc(cc1)-c1cc(C(O)=O)c2ccccc2n1 InChI=1S/C17H13NO3/c1-21-12-8-6-11(7-9-12)16-10-14(17(19)20)13-4-2-3-5-15(13)18-16/h2-10H,1H3,(H,19,20) ZCNPYYVKVXSLQF-UHFFFAOYSA-N 50097112 2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid::CHEMBL149961 Proline--tRNA ligase, cytoplasmic Candida albicans >100000 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097112&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 676325 103994506 CHEMBL149961 ZINC00039344 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174492 OCc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(O)=O InChI=1S/C17H11BrClNO3/c18-11-3-1-9(2-4-11)15-7-14(17(22)23)13-6-12(19)5-10(8-21)16(13)20-15/h1-7,21H,8H2,(H,22,23) DUOBHYYPJLHJLP-UHFFFAOYSA-N 50097109 2-(4-Bromo-phenyl)-6-chloro-8-hydroxymethyl-quinoline-4-carboxylic acid::CHEMBL150407 Proline--tRNA ligase, cytoplasmic Candida albicans 1500 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097109&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 44367229 103994503 CHEMBL150407 ZINC27620891 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174494 OC(=O)c1cc(nc2ccc(OC(F)(F)F)cc12)-c1ccc(Br)cc1 InChI=1S/C17H9BrF3NO3/c18-10-3-1-9(2-4-10)15-8-13(16(23)24)12-7-11(25-17(19,20)21)5-6-14(12)22-15/h1-8H,(H,23,24) BWQDDNKERUHLMM-UHFFFAOYSA-N 50097113 2-(4-Bromo-phenyl)-6-trifluoromethoxy-quinoline-4-carboxylic acid::CHEMBL153295 Proline--tRNA ligase, cytoplasmic Candida albicans 53.0 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097113&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275522 103994507 CHEMBL153295 ZINC27634884 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600 50174496 OC(=O)c1cc(nc2c(cc(Br)cc12)C(F)(F)F)-c1ccc(Br)cc1 InChI=1S/C17H8Br2F3NO2/c18-9-3-1-8(2-4-9)14-7-12(16(24)25)11-5-10(19)6-13(15(11)23-14)17(20,21)22/h1-7H,(H,24,25) FBQTXJDDFXHOGW-UHFFFAOYSA-N 50097104 6-Bromo-2-(4-bromo-phenyl)-8-trifluoromethyl-quinoline-4-carboxylic acid::CHEMBL149973 Proline--tRNA ligase, cytoplasmic Candida albicans 220 ChEMBL 10.1016/s0960-894x(00)00697-1 10.7270/Q2Q23ZH8 11229766 Yu, XY; Hill, JM; Yu, G; Yang, Y; Kluge, AF; Keith, D; Finn, J; Gallant, P; Silverman, J; Lim, A Cubist Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50097104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000662&target=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50097104&enzyme=Proline--tRNA+ligase%2C+cytoplasmic&column=ki&startPg=0&Increment=50&submit=Search 5275531 103994498 CHEMBL149973 ZINC27621218 1 MIIIKRFLHIKTVPKSYGNQLSKFKYSKQIPTHEVLTKLGYITYPRAGLVNWSKMGLLIQNKISQIIRQRMDEIQFEEVSLSLISHKELWKLTNRWDQEEIFKLVGDEYLLVPTAEEEITNYVKKQFLESYKNFPLALYQINPKFRNEKRPRGGLLRGKEFLMKDAYSFDLNESEAMKTYEKVVGAYHKIFQDLGIPYVKAEADSGDIGGSLSHEWHYLNSSGEDTVFECNECHNVSNMEKALSYPKEIDETIEVSVIYFTTEDKSTLICAYYPSNRVLEPKFIQNEIPDIDLDSINDLSEFNHDISTRIVRIMDSRLSSRSKFPDFPISNFINRSLITTLTDIPIVLAQEGEICGHCEEGKLSASSAIEVGHTFYLGDKYSKPLDLEVDVPTSNNSIEKQRIMMGCYGIGISRIIAAIAEINRDEKGLKWPRSIAPWEVTVVEVSKQKQLKNVNDNNHHNNPQDNFQEIYNILNQANIDYRLDNRSDSMGKKLKQSDLLGIPLSIILGNQYPIIEIEVRGNKKNNNNNSWLQSYTENKDQFDWKVETDAQGNDTKHYIHKDGLVTVVNSLLNDM Proline--tRNA ligase, cytoplasmic SYPC_CANAX P78600