BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51034313 CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O InChI=1S/C107H152N28O27S2/c1-55(2)45-79(105(161)162)131-93(149)70(29-18-19-41-108)123-91(147)71(30-20-42-115-106(111)112)122-87(143)57(4)118-94(150)73(49-65-33-37-67(137)38-34-65)129-101(157)81-54-164-163-53-80(132-99(155)75(50-66-35-39-68(138)40-36-66)126-89(145)59(6)121-103(159)85(61(8)136)134-90(146)60(7)117-86(142)56(3)120-102(158)82-32-22-44-135(82)104(160)69(109)51-84(140)141)100(156)124-72(31-21-43-116-107(113)114)92(148)127-76(47-63-25-14-10-15-26-63)96(152)128-77(48-64-27-16-11-17-28-64)97(153)130-78(52-83(110)139)95(151)119-58(5)88(144)125-74(98(154)133-81)46-62-23-12-9-13-24-62/h9-17,23-28,33-40,55-61,69-82,85,136-138H,18-22,29-32,41-54,108-109H2,1-8H3,(H2,110,139)(H,117,142)(H,118,150)(H,119,151)(H,120,158)(H,121,159)(H,122,143)(H,123,147)(H,124,156)(H,125,144)(H,126,145)(H,127,148)(H,128,152)(H,129,157)(H,130,153)(H,131,149)(H,132,155)(H,133,154)(H,134,146)(H,140,141)(H,161,162)(H4,111,112,115)(H4,113,114,116)/t56-,57-,58-,59-,60-,61+,69-,70-,71-,72+,73-,74-,75-,76+,77-,78-,79-,80-,81-,82-,85-/m0/s1 CELKUTCQMPOERU-CFQMNPQXSA-N 50422955 CHEMBL2304248 Melanocortin receptor 4 Mus musculus 8300 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422955&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71717865 164151830 CHEMBL2304248 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51034314 CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O InChI=1S/C107H152N28O27S2/c1-55(2)45-79(105(161)162)131-93(149)70(29-18-19-41-108)123-91(147)71(30-20-42-115-106(111)112)122-87(143)57(4)118-94(150)73(49-65-33-37-67(137)38-34-65)129-101(157)81-54-164-163-53-80(132-99(155)75(50-66-35-39-68(138)40-36-66)126-89(145)59(6)121-103(159)85(61(8)136)134-90(146)60(7)117-86(142)56(3)120-102(158)82-32-22-44-135(82)104(160)69(109)51-84(140)141)100(156)124-72(31-21-43-116-107(113)114)92(148)127-76(47-63-25-14-10-15-26-63)96(152)128-77(48-64-27-16-11-17-28-64)97(153)130-78(52-83(110)139)95(151)119-58(5)88(144)125-74(98(154)133-81)46-62-23-12-9-13-24-62/h9-17,23-28,33-40,55-61,69-82,85,136-138H,18-22,29-32,41-54,108-109H2,1-8H3,(H2,110,139)(H,117,142)(H,118,150)(H,119,151)(H,120,158)(H,121,159)(H,122,143)(H,123,147)(H,124,156)(H,125,144)(H,126,145)(H,127,148)(H,128,152)(H,129,157)(H,130,153)(H,131,149)(H,132,155)(H,133,154)(H,134,146)(H,140,141)(H,161,162)(H4,111,112,115)(H4,113,114,116)/t56-,57-,58-,59-,60-,61+,69-,70-,71-,72-,73-,74-,75-,76?,77+,78-,79-,80-,81-,82-,85-/m0/s1 CELKUTCQMPOERU-FVEMCSNLSA-N 50422956 CHEMBL2304249 Melanocortin receptor 4 Mus musculus 6240 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422956&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71719701 164151831 CHEMBL2304249 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51034318 CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O InChI=1S/C107H152N28O27S2/c1-55(2)45-79(105(161)162)131-93(149)70(29-18-19-41-108)123-91(147)71(30-20-42-115-106(111)112)122-87(143)57(4)118-94(150)73(49-65-33-37-67(137)38-34-65)129-101(157)81-54-164-163-53-80(132-99(155)75(50-66-35-39-68(138)40-36-66)126-89(145)59(6)121-103(159)85(61(8)136)134-90(146)60(7)117-86(142)56(3)120-102(158)82-32-22-44-135(82)104(160)69(109)51-84(140)141)100(156)124-72(31-21-43-116-107(113)114)92(148)127-76(47-63-25-14-10-15-26-63)96(152)128-77(48-64-27-16-11-17-28-64)97(153)130-78(52-83(110)139)95(151)119-58(5)88(144)125-74(98(154)133-81)46-62-23-12-9-13-24-62/h9-17,23-28,33-40,55-61,69-82,85,136-138H,18-22,29-32,41-54,108-109H2,1-8H3,(H2,110,139)(H,117,142)(H,118,150)(H,119,151)(H,120,158)(H,121,159)(H,122,143)(H,123,147)(H,124,156)(H,125,144)(H,126,145)(H,127,148)(H,128,152)(H,129,157)(H,130,153)(H,131,149)(H,132,155)(H,133,154)(H,134,146)(H,140,141)(H,161,162)(H4,111,112,115)(H4,113,114,116)/t56-,57-,58-,59-,60-,61+,69-,70-,71-,72+,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,85-/m0/s1 CELKUTCQMPOERU-FKOFVIELSA-N 50422957 CHEMBL2304250 Melanocortin receptor 4 Mus musculus 37700 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422957&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71716059 164151832 CHEMBL2304250 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51034323 CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O InChI=1S/C107H152N28O27S2/c1-55(2)45-79(105(161)162)131-93(149)70(29-18-19-41-108)123-91(147)71(30-20-42-115-106(111)112)122-87(143)57(4)118-94(150)73(49-65-33-37-67(137)38-34-65)129-101(157)81-54-164-163-53-80(132-99(155)75(50-66-35-39-68(138)40-36-66)126-89(145)59(6)121-103(159)85(61(8)136)134-90(146)60(7)117-86(142)56(3)120-102(158)82-32-22-44-135(82)104(160)69(109)51-84(140)141)100(156)124-72(31-21-43-116-107(113)114)92(148)127-76(47-63-25-14-10-15-26-63)96(152)128-77(48-64-27-16-11-17-28-64)97(153)130-78(52-83(110)139)95(151)119-58(5)88(144)125-74(98(154)133-81)46-62-23-12-9-13-24-62/h9-17,23-28,33-40,55-61,69-82,85,136-138H,18-22,29-32,41-54,108-109H2,1-8H3,(H2,110,139)(H,117,142)(H,118,150)(H,119,151)(H,120,158)(H,121,159)(H,122,143)(H,123,147)(H,124,156)(H,125,144)(H,126,145)(H,127,148)(H,128,152)(H,129,157)(H,130,153)(H,131,149)(H,132,155)(H,133,154)(H,134,146)(H,140,141)(H,161,162)(H4,111,112,115)(H4,113,114,116)/t56-,57-,58-,59-,60-,61+,69-,70-,71-,72-,73-,74-,75-,76+,77-,78-,79-,80-,81-,82-,85-/m0/s1 CELKUTCQMPOERU-IQOAFJSOSA-N 50422954 CHEMBL2304247 Melanocortin receptor 4 Mus musculus 6.9 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422954&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900217 164151829 CHEMBL2304247 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51034327 CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O InChI=1S/C107H152N28O27S2/c1-55(2)45-79(105(161)162)131-93(149)70(29-18-19-41-108)123-91(147)71(30-20-42-115-106(111)112)122-87(143)57(4)118-94(150)73(49-65-33-37-67(137)38-34-65)129-101(157)81-54-164-163-53-80(132-99(155)75(50-66-35-39-68(138)40-36-66)126-89(145)59(6)121-103(159)85(61(8)136)134-90(146)60(7)117-86(142)56(3)120-102(158)82-32-22-44-135(82)104(160)69(109)51-84(140)141)100(156)124-72(31-21-43-116-107(113)114)92(148)127-76(47-63-25-14-10-15-26-63)96(152)128-77(48-64-27-16-11-17-28-64)97(153)130-78(52-83(110)139)95(151)119-58(5)88(144)125-74(98(154)133-81)46-62-23-12-9-13-24-62/h9-17,23-28,33-40,55-61,69-82,85,136-138H,18-22,29-32,41-54,108-109H2,1-8H3,(H2,110,139)(H,117,142)(H,118,150)(H,119,151)(H,120,158)(H,121,159)(H,122,143)(H,123,147)(H,124,156)(H,125,144)(H,126,145)(H,127,148)(H,128,152)(H,129,157)(H,130,153)(H,131,149)(H,132,155)(H,133,154)(H,134,146)(H,140,141)(H,161,162)(H4,111,112,115)(H4,113,114,116)/t56-,57-,58-,59-,60-,61+,69-,70-,71-,72+,73-,74-,75-,76-,77+,78-,79-,80-,81-,82-,85-/m0/s1 CELKUTCQMPOERU-GDIOOMNQSA-N 50422958 CHEMBL2304246 Melanocortin receptor 4 Mus musculus 8330 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422958&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71717864 164151833 CHEMBL2304246 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51034331 CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O InChI=1S/C107H152N28O27S2/c1-55(2)45-79(105(161)162)131-93(149)70(29-18-19-41-108)123-91(147)71(30-20-42-115-106(111)112)122-87(143)57(4)118-94(150)73(49-65-33-37-67(137)38-34-65)129-101(157)81-54-164-163-53-80(132-99(155)75(50-66-35-39-68(138)40-36-66)126-89(145)59(6)121-103(159)85(61(8)136)134-90(146)60(7)117-86(142)56(3)120-102(158)82-32-22-44-135(82)104(160)69(109)51-84(140)141)100(156)124-72(31-21-43-116-107(113)114)92(148)127-76(47-63-25-14-10-15-26-63)96(152)128-77(48-64-27-16-11-17-28-64)97(153)130-78(52-83(110)139)95(151)119-58(5)88(144)125-74(98(154)133-81)46-62-23-12-9-13-24-62/h9-17,23-28,33-40,55-61,69-82,85,136-138H,18-22,29-32,41-54,108-109H2,1-8H3,(H2,110,139)(H,117,142)(H,118,150)(H,119,151)(H,120,158)(H,121,159)(H,122,143)(H,123,147)(H,124,156)(H,125,144)(H,126,145)(H,127,148)(H,128,152)(H,129,157)(H,130,153)(H,131,149)(H,132,155)(H,133,154)(H,134,146)(H,140,141)(H,161,162)(H4,111,112,115)(H4,113,114,116)/t56-,57-,58-,59-,60-,61+,69-,70-,71-,72-,73-,74-,75-,76?,77+,78-,79-,80-,81-,82-,85-/m0/s1 CELKUTCQMPOERU-FVEMCSNLSA-N 50422956 CHEMBL2304249 Melanocortin receptor 4 Mus musculus 3700 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422956&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71719701 164151831 CHEMBL2304249 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51034335 CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O InChI=1S/C107H152N28O27S2/c1-55(2)45-79(105(161)162)131-93(149)70(29-18-19-41-108)123-91(147)71(30-20-42-115-106(111)112)122-87(143)57(4)118-94(150)73(49-65-33-37-67(137)38-34-65)129-101(157)81-54-164-163-53-80(132-99(155)75(50-66-35-39-68(138)40-36-66)126-89(145)59(6)121-103(159)85(61(8)136)134-90(146)60(7)117-86(142)56(3)120-102(158)82-32-22-44-135(82)104(160)69(109)51-84(140)141)100(156)124-72(31-21-43-116-107(113)114)92(148)127-76(47-63-25-14-10-15-26-63)96(152)128-77(48-64-27-16-11-17-28-64)97(153)130-78(52-83(110)139)95(151)119-58(5)88(144)125-74(98(154)133-81)46-62-23-12-9-13-24-62/h9-17,23-28,33-40,55-61,69-82,85,136-138H,18-22,29-32,41-54,108-109H2,1-8H3,(H2,110,139)(H,117,142)(H,118,150)(H,119,151)(H,120,158)(H,121,159)(H,122,143)(H,123,147)(H,124,156)(H,125,144)(H,126,145)(H,127,148)(H,128,152)(H,129,157)(H,130,153)(H,131,149)(H,132,155)(H,133,154)(H,134,146)(H,140,141)(H,161,162)(H4,111,112,115)(H4,113,114,116)/t56-,57-,58-,59-,60-,61+,69-,70-,71-,72-,73-,74-,75-,76+,77-,78-,79-,80-,81-,82-,85-/m0/s1 CELKUTCQMPOERU-IQOAFJSOSA-N 50422954 CHEMBL2304247 Melanocortin receptor 4 Mus musculus 6.6 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422954&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900217 164151829 CHEMBL2304247 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51034338 CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)CC(O)=O)[C@@H](C)O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(O)=O InChI=1S/C107H152N28O27S2/c1-55(2)45-79(105(161)162)131-93(149)70(29-18-19-41-108)123-91(147)71(30-20-42-115-106(111)112)122-87(143)57(4)118-94(150)73(49-65-33-37-67(137)38-34-65)129-101(157)81-54-164-163-53-80(132-99(155)75(50-66-35-39-68(138)40-36-66)126-89(145)59(6)121-103(159)85(61(8)136)134-90(146)60(7)117-86(142)56(3)120-102(158)82-32-22-44-135(82)104(160)69(109)51-84(140)141)100(156)124-72(31-21-43-116-107(113)114)92(148)127-76(47-63-25-14-10-15-26-63)96(152)128-77(48-64-27-16-11-17-28-64)97(153)130-78(52-83(110)139)95(151)119-58(5)88(144)125-74(98(154)133-81)46-62-23-12-9-13-24-62/h9-17,23-28,33-40,55-61,69-82,85,136-138H,18-22,29-32,41-54,108-109H2,1-8H3,(H2,110,139)(H,117,142)(H,118,150)(H,119,151)(H,120,158)(H,121,159)(H,122,143)(H,123,147)(H,124,156)(H,125,144)(H,126,145)(H,127,148)(H,128,152)(H,129,157)(H,130,153)(H,131,149)(H,132,155)(H,133,154)(H,134,146)(H,140,141)(H,161,162)(H4,111,112,115)(H4,113,114,116)/t56-,57-,58-,59-,60-,61+,69-,70-,71-,72+,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,85-/m0/s1 CELKUTCQMPOERU-FKOFVIELSA-N 50422957 CHEMBL2304250 Melanocortin receptor 4 Mus musculus 8330 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50422957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50422957&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71716059 164151832 CHEMBL2304250 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50020371 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 82411 CAS_75921-69-6::NDP-MSH Melanocortin receptor 4 Mus musculus 120 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82411&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91898441 136350382 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50065324 Fc1cccc(F)c1CSc1ccccc1C1=NCCCN1 InChI=1S/C17H16F2N2S/c18-14-6-3-7-15(19)13(14)11-22-16-8-2-1-5-12(16)17-20-9-4-10-21-17/h1-3,5-8H,4,9-11H2,(H,20,21) IIXSESNTPZDVOB-UHFFFAOYSA-N 50142892 2-[2-(2,6-Difluoro-benzylsulfanyl)-phenyl]-1,4,5,6-tetrahydro-pyrimidine::CHEMBL289532 Melanocortin receptor 4 Mus musculus 15800 ChEMBL 10.1021/jm034244g 10.7270/Q2JQ10GG 15027849 Vos, TJ; Caracoti, A; Che, JL; Dai, M; Farrer, CA; Forsyth, NE; Drabic, SV; Horlick, RA; Lamppu, D; Yowe, DL; Balani, S; Li, P; Zeng, H; Joseph, IB; Rodriguez, LE; Maguire, MP; Patane, MA; Claiborne, CF Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142892&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 2804382 104032207 CHEMBL289532 ZINC00139183 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50065325 COc1ccc(Br)cc1CCc1c(F)cccc1C1=NCCN1 InChI=1S/C18H18BrFN2O/c1-23-17-8-6-13(19)11-12(17)5-7-14-15(3-2-4-16(14)20)18-21-9-10-22-18/h2-4,6,8,11H,5,7,9-10H2,1H3,(H,21,22) WCPPZGPJRHLSKP-UHFFFAOYSA-N 50142895 2-(2-(5-bromo-2-methoxyphenethyl)-3-fluorophenyl)-4,5-dihydro-1H-imidazole::2-phenylimidazoline::2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-3-fluoro-phenyl}-4,5-dihydro-1H-imidazole::CHEMBL40711::ML-253764 Melanocortin receptor 4 Mus musculus 160 ChEMBL 10.1021/jm034244g 10.7270/Q2JQ10GG 15027849 Vos, TJ; Caracoti, A; Che, JL; Dai, M; Farrer, CA; Forsyth, NE; Drabic, SV; Horlick, RA; Lamppu, D; Yowe, DL; Balani, S; Li, P; Zeng, H; Joseph, IB; Rodriguez, LE; Maguire, MP; Patane, MA; Claiborne, CF Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142895&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9842665 104032210 CHEMBL40711 ZINC03938671 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50065326 COc1ccc(Br)cc1CSc1ccccc1C1=NCCCN1 InChI=1S/C18H19BrN2OS/c1-22-16-8-7-14(19)11-13(16)12-23-17-6-3-2-5-15(17)18-20-9-4-10-21-18/h2-3,5-8,11H,4,9-10,12H2,1H3,(H,20,21) QMSDCVRXVFCLRL-UHFFFAOYSA-N 50142894 2-[2-(5-Bromo-2-methoxy-benzylsulfanyl)-phenyl]-1,4,5,6-tetrahydro-pyrimidine::CHEMBL416244 Melanocortin receptor 4 Mus musculus 67 ChEMBL 10.1021/jm034244g 10.7270/Q2JQ10GG 15027849 Vos, TJ; Caracoti, A; Che, JL; Dai, M; Farrer, CA; Forsyth, NE; Drabic, SV; Horlick, RA; Lamppu, D; Yowe, DL; Balani, S; Li, P; Zeng, H; Joseph, IB; Rodriguez, LE; Maguire, MP; Patane, MA; Claiborne, CF Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142894&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10293816 104032209 CHEMBL416244 ZINC00590622 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50065327 COc1ccc(Br)cc1CCc1ccccc1C1=NCCN1 InChI=1S/C18H19BrN2O/c1-22-17-9-8-15(19)12-14(17)7-6-13-4-2-3-5-16(13)18-20-10-11-21-18/h2-5,8-9,12H,6-7,10-11H2,1H3,(H,20,21) UGEWWDGQZJPIRF-UHFFFAOYSA-N 50142891 2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-phenyl}-4,5-dihydro-1H-imidazole::CHEMBL435368 Melanocortin receptor 4 Mus musculus 39 ChEMBL 10.1021/jm034244g 10.7270/Q2JQ10GG 15027849 Vos, TJ; Caracoti, A; Che, JL; Dai, M; Farrer, CA; Forsyth, NE; Drabic, SV; Horlick, RA; Lamppu, D; Yowe, DL; Balani, S; Li, P; Zeng, H; Joseph, IB; Rodriguez, LE; Maguire, MP; Patane, MA; Claiborne, CF Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142891&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11245316 104032206 CHEMBL435368 ZINC13559856 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50065328 Clc1cc(CSc2ccccc2C2=NCCCN2)c(Cl)s1 InChI=1S/C15H14Cl2N2S2/c16-13-8-10(14(17)21-13)9-20-12-5-2-1-4-11(12)15-18-6-3-7-19-15/h1-2,4-5,8H,3,6-7,9H2,(H,18,19) LTWCBBRXEBVHTH-UHFFFAOYSA-N 50142893 2-[2-(2,5-Dichloro-thiophen-3-ylmethylsulfanyl)-phenyl]-1,4,5,6-tetrahydro-pyrimidine::CHEMBL287895 Melanocortin receptor 4 Mus musculus 2200 ChEMBL 10.1021/jm034244g 10.7270/Q2JQ10GG 15027849 Vos, TJ; Caracoti, A; Che, JL; Dai, M; Farrer, CA; Forsyth, NE; Drabic, SV; Horlick, RA; Lamppu, D; Yowe, DL; Balani, S; Li, P; Zeng, H; Joseph, IB; Rodriguez, LE; Maguire, MP; Patane, MA; Claiborne, CF Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142893&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 2806083 104032208 CHEMBL287895 ZINC04323439 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50065331 COc1ccc(Br)cc1CCc1ccccc1C1=NCCCN1 InChI=1S/C19H21BrN2O/c1-23-18-10-9-16(20)13-15(18)8-7-14-5-2-3-6-17(14)19-21-11-4-12-22-19/h2-3,5-6,9-10,13H,4,7-8,11-12H2,1H3,(H,21,22) WMSIKZDVBSROMD-UHFFFAOYSA-N 50142897 2-{2-[2-(5-Bromo-2-methoxy-phenyl)-ethyl]-phenyl}-1,4,5,6-tetrahydro-pyrimidine::CHEMBL40233 Melanocortin receptor 4 Mus musculus 220 ChEMBL 10.1021/jm034244g 10.7270/Q2JQ10GG 15027849 Vos, TJ; Caracoti, A; Che, JL; Dai, M; Farrer, CA; Forsyth, NE; Drabic, SV; Horlick, RA; Lamppu, D; Yowe, DL; Balani, S; Li, P; Zeng, H; Joseph, IB; Rodriguez, LE; Maguire, MP; Patane, MA; Claiborne, CF Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142897&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9864301 104032212 CHEMBL40233 ZINC13559855 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50065333 Fc1cccc(Cl)c1CSc1ccccc1C1=NCCCN1 InChI=1S/C17H16ClFN2S/c18-14-6-3-7-15(19)13(14)11-22-16-8-2-1-5-12(16)17-20-9-4-10-21-17/h1-3,5-8H,4,9-11H2,(H,20,21) LTKNAMJHFJKCLP-UHFFFAOYSA-N 50142896 2-[2-(2-Chloro-6-fluoro-benzylsulfanyl)-phenyl]-1,4,5,6-tetrahydro-pyrimidine::CHEMBL40857 Melanocortin receptor 4 Mus musculus 2700 ChEMBL 10.1021/jm034244g 10.7270/Q2JQ10GG 15027849 Vos, TJ; Caracoti, A; Che, JL; Dai, M; Farrer, CA; Forsyth, NE; Drabic, SV; Horlick, RA; Lamppu, D; Yowe, DL; Balani, S; Li, P; Zeng, H; Joseph, IB; Rodriguez, LE; Maguire, MP; Patane, MA; Claiborne, CF Millennium Pharmaceuticals Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50142896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50142896&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 605683 104032211 CHEMBL40857 ZINC00139184 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50099972 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(cc1)[N+]([O-])=O)C(N)=O InChI=1S/C36H37IN8O7/c1-21(46)41-30(17-27-18-39-20-40-27)34(48)43-31(15-22-6-10-26(37)11-7-22)36(50)44-19-25-5-3-2-4-24(25)16-32(44)35(49)42-29(33(38)47)14-23-8-12-28(13-9-23)45(51)52/h2-13,18,20,29-32H,14-17,19H2,1H3,(H2,38,47)(H,39,40)(H,41,46)(H,42,49)(H,43,48)/t29-,30+,31-,32?/m1/s1 IRYMLYQXVLFVAF-NUMJAJDCSA-N 50017128 CHEMBL3287322 Melanocortin receptor 4 Mus musculus 2.4 ChEMBL 10.1021/jm500064t 10.7270/Q2VQ347J 24517312 Haslach, EM; Huang, H; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Doering, SR; Walters, MA; Houghten, RA; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017128&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 90643802 103928456 CHEMBL3287322 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50099973 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O InChI=1S/C32H40I2N10O5/c1-18(45)41-27(15-23-16-38-17-40-23)31(49)44-26(14-20-6-10-22(34)11-7-20)30(48)42-24(3-2-12-39-32(36)37)29(47)43-25(28(35)46)13-19-4-8-21(33)9-5-19/h4-11,16-17,24-27H,2-3,12-15H2,1H3,(H2,35,46)(H,38,40)(H,41,45)(H,42,48)(H,43,47)(H,44,49)(H4,36,37,39)/t24-,25-,26+,27-/m0/s1 VRQUIVOUDQMPCM-NFGXINMFSA-N 50017130 CHEMBL3287323 Melanocortin receptor 4 Mus musculus 0.700000 ChEMBL 10.1021/jm500064t 10.7270/Q2VQ347J 24517312 Haslach, EM; Huang, H; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Doering, SR; Walters, MA; Houghten, RA; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017130&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 90643803 242041718 CHEMBL3287323 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50099974 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(cc1)[N+]([O-])=O)C(N)=O InChI=1S/C36H42IN9O7/c1-21(47)42-28(7-4-16-41-36(39)40)33(49)44-30(18-22-8-12-26(37)13-9-22)35(51)45-20-25-6-3-2-5-24(25)19-31(45)34(50)43-29(32(38)48)17-23-10-14-27(15-11-23)46(52)53/h2-3,5-6,8-15,28-31H,4,7,16-20H2,1H3,(H2,38,48)(H,42,47)(H,43,50)(H,44,49)(H4,39,40,41)/t28-,29+,30+,31?/m0/s1 LVZVUZUDRDMDPR-LVCGBWMPSA-N 50017131 CHEMBL3287324 Melanocortin receptor 4 Mus musculus 2.7 ChEMBL 10.1021/jm500064t 10.7270/Q2VQ347J 24517312 Haslach, EM; Huang, H; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Doering, SR; Walters, MA; Houghten, RA; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017131&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 90643804 242041719 CHEMBL3287324 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50099975 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O InChI=1S/C32H45I2N11O5/c1-18(46)42-23(4-2-14-40-31(36)37)28(48)45-26(17-20-8-12-22(34)13-9-20)30(50)43-24(5-3-15-41-32(38)39)29(49)44-25(27(35)47)16-19-6-10-21(33)11-7-19/h6-13,23-26H,2-5,14-17H2,1H3,(H2,35,47)(H,42,46)(H,43,50)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t23-,24-,25-,26+/m0/s1 PHPBSUCWKAPUKN-ASDGIDEWSA-N 50017132 CHEMBL3287325 Melanocortin receptor 4 Mus musculus 4.3 ChEMBL 10.1021/jm500064t 10.7270/Q2VQ347J 24517312 Haslach, EM; Huang, H; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Doering, SR; Walters, MA; Houghten, RA; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017132&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 90643805 242041720 CHEMBL3287325 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50099976 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(cc1)[N+]([O-])=O)C(N)=O InChI=1S/C36H37ClN8O7/c1-21(46)41-30(17-27-18-39-20-40-27)34(48)43-31(15-22-6-10-26(37)11-7-22)36(50)44-19-25-5-3-2-4-24(25)16-32(44)35(49)42-29(33(38)47)14-23-8-12-28(13-9-23)45(51)52/h2-13,18,20,29-32H,14-17,19H2,1H3,(H2,38,47)(H,39,40)(H,41,46)(H,42,49)(H,43,48)/t29-,30+,31-,32?/m1/s1 YWGVRYQGDWGUEQ-NUMJAJDCSA-N 50017133 CHEMBL3287326 Melanocortin receptor 4 Mus musculus 5.2 ChEMBL 10.1021/jm500064t 10.7270/Q2VQ347J 24517312 Haslach, EM; Huang, H; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Doering, SR; Walters, MA; Houghten, RA; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017133&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 90643806 242041721 CHEMBL3287326 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50099977 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O InChI=1S/C32H40ClIN10O5/c1-18(45)41-27(15-23-16-38-17-40-23)31(49)44-26(14-19-4-8-21(33)9-5-19)30(48)42-24(3-2-12-39-32(36)37)29(47)43-25(28(35)46)13-20-6-10-22(34)11-7-20/h4-11,16-17,24-27H,2-3,12-15H2,1H3,(H2,35,46)(H,38,40)(H,41,45)(H,42,48)(H,43,47)(H,44,49)(H4,36,37,39)/t24-,25-,26+,27-/m0/s1 QZGVEZCPDSNBNU-NFGXINMFSA-N 50017134 CHEMBL3287327 Melanocortin receptor 4 Mus musculus 3.1 ChEMBL 10.1021/jm500064t 10.7270/Q2VQ347J 24517312 Haslach, EM; Huang, H; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Doering, SR; Walters, MA; Houghten, RA; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017134&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 90643807 242041722 CHEMBL3287327 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50099978 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@H](Cc1ccc(cc1)[N+]([O-])=O)C(N)=O InChI=1S/C36H42ClN9O7/c1-21(47)42-28(7-4-16-41-36(39)40)33(49)44-30(18-22-8-12-26(37)13-9-22)35(51)45-20-25-6-3-2-5-24(25)19-31(45)34(50)43-29(32(38)48)17-23-10-14-27(15-11-23)46(52)53/h2-3,5-6,8-15,28-31H,4,7,16-20H2,1H3,(H2,38,48)(H,42,47)(H,43,50)(H,44,49)(H4,39,40,41)/t28-,29+,30+,31?/m0/s1 VUNSGMTWWHNMCR-LVCGBWMPSA-N 50017135 CHEMBL3287328 Melanocortin receptor 4 Mus musculus 7.6 ChEMBL 10.1021/jm500064t 10.7270/Q2VQ347J 24517312 Haslach, EM; Huang, H; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Doering, SR; Walters, MA; Houghten, RA; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017135&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 90643808 242041723 CHEMBL3287328 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50099979 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(I)cc1)C(N)=O InChI=1S/C32H45ClIN11O5/c1-18(46)42-23(4-2-14-40-31(36)37)28(48)45-26(17-19-6-10-21(33)11-7-19)30(50)43-24(5-3-15-41-32(38)39)29(49)44-25(27(35)47)16-20-8-12-22(34)13-9-20/h6-13,23-26H,2-5,14-17H2,1H3,(H2,35,47)(H,42,46)(H,43,50)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t23-,24-,25-,26+/m0/s1 XNNYSCVYNQVQJY-ASDGIDEWSA-N 50017136 CHEMBL3287329 Melanocortin receptor 4 Mus musculus 7.4 ChEMBL 10.1021/jm500064t 10.7270/Q2VQ347J 24517312 Haslach, EM; Huang, H; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Doering, SR; Walters, MA; Houghten, RA; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017136&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 90643809 242041724 CHEMBL3287329 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50100103 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.120000 ChEMBL 10.1021/jm500064t 10.7270/Q2VQ347J 24517312 Haslach, EM; Huang, H; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Doering, SR; Walters, MA; Houghten, RA; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50124792 CC[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(O)=O)NC(=O)[C@H](CC)NC(=O)[C@H](N)CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CSSC[C@H](NC(=O)[C@@H](Cc3ccc(O)cc3)NC(=O)[C@H](CC)NC(=O)[C@@H](NC(=O)[C@@H](C)NC1=O)[C@@H](C)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O InChI=1S/C116H166N30O29S4/c1-9-72-96(156)126-62(7)94(154)145-92(63(8)147)112(172)130-74(11-3)97(157)135-81(52-67-36-40-69(148)41-37-67)106(166)143-87-58-178-179-59-88(144-105(165)78(49-64-26-15-12-16-27-64)134-93(153)61(6)127-102(162)83(54-90(119)150)139-104(164)80(51-66-30-19-14-20-31-66)137-103(163)79(50-65-28-17-13-18-29-65)136-100(160)77(133-109(87)169)34-24-46-125-116(122)123)110(170)138-82(53-68-38-42-70(149)43-39-68)107(167)142-86(108(168)132-76(33-23-45-124-115(120)121)99(159)131-75(32-21-22-44-117)101(161)141-85(114(174)175)48-60(4)5)57-177-176-56-71(118)95(155)128-73(10-2)98(158)140-84(55-91(151)152)113(173)146-47-25-35-89(146)111(171)129-72/h12-20,26-31,36-43,60-63,71-89,92,147-149H,9-11,21-25,32-35,44-59,117-118H2,1-8H3,(H2,119,150)(H,126,156)(H,127,162)(H,128,155)(H,129,171)(H,130,172)(H,131,159)(H,132,168)(H,133,169)(H,134,153)(H,135,157)(H,136,160)(H,137,163)(H,138,170)(H,139,164)(H,140,158)(H,141,161)(H,142,167)(H,143,166)(H,144,165)(H,145,154)(H,151,152)(H,174,175)(H4,120,121,124)(H4,122,123,125)/t61-,62-,63-,71?,72?,73?,74?,75+,76+,77?,78+,79+,80-,81-,82+,83?,84?,85+,86+,87+,88-,89+,92+/m1/s1 WEGMWHQAGOCAEG-AXFKQYECSA-N 50155865 CHEMBL2373991::CUDPUATUYCRFFNAFCYCRKL Melanocortin receptor 4 Mus musculus 10 ChEMBL 10.1021/jm049620r 10.7270/Q21N80MK 15509165 Wilczynski, A; Wang, XS; Bauzo, RM; Xiang, Z; Shaw, AM; Millard, WJ; Richards, NG; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50155865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50155865&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 73348775 104043232 CHEMBL2373991 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50129704 CN1C[C@H]2CC[C@@H]1[C@@H](C2)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C InChI=1S/C34H51FN4O3/c1-33(2,3)37-32(42)34(25-8-6-5-7-9-25)16-18-39(19-17-34)31(41)28(21-23-10-13-26(35)14-11-23)36-30(40)27-20-24-12-15-29(27)38(4)22-24/h10-11,13-14,24-25,27-29H,5-9,12,15-22H2,1-4H3,(H,36,40)(H,37,42)/t24-,27+,28+,29+/m0/s1 ARFBDECCXOFCBN-HOLBEBDISA-N 50169442 (1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide::CHEMBL364346 Melanocortin receptor 4 Mus musculus 6000 ChEMBL 10.1016/j.bmcl.2005.05.109 10.7270/Q2Q81CKF 15982875 Ye, Z; Guo, L; Barakat, KJ; Pollard, PG; Palucki, BL; Sebhat, IK; Bakshi, RK; Tang, R; Kalyani, RN; Vongs, A; Chen, AS; Chen, HY; Rosenblum, CI; MacNeil, T; Weinberg, DH; Peng, Q; Tamvakopoulos, C; Miller, RR; Stearns, RA; Cashen, DE; Martin, WJ; Metzger, JM; Strack, AM; MacIntyre, DE; Van der Ploeg, LH; Patchett, AA; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169442&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 6918851 104054247 CHEMBL364346 1337 ZINC14209775 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50129739 CN1C[C@H]2CC[C@@H]1[C@@H](C2)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(CC1)(C1CCCCC1)C(=O)NC(C)(C)C InChI=1S/C34H51FN4O3/c1-33(2,3)37-32(42)34(25-8-6-5-7-9-25)16-18-39(19-17-34)31(41)28(21-23-10-13-26(35)14-11-23)36-30(40)27-20-24-12-15-29(27)38(4)22-24/h10-11,13-14,24-25,27-29H,5-9,12,15-22H2,1-4H3,(H,36,40)(H,37,42)/t24-,27+,28+,29+/m0/s1 ARFBDECCXOFCBN-HOLBEBDISA-N 50169442 (1R,4S,6R)-2-Methyl-2-aza-bicyclo[2.2.2]octane-6-carboxylic acid [(R)-2-(4-tert-butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethyl]-amide::CHEMBL364346 Melanocortin receptor 4 Mus musculus 3000 ChEMBL 10.1016/j.bmcl.2005.05.109 10.7270/Q2Q81CKF 15982875 Ye, Z; Guo, L; Barakat, KJ; Pollard, PG; Palucki, BL; Sebhat, IK; Bakshi, RK; Tang, R; Kalyani, RN; Vongs, A; Chen, AS; Chen, HY; Rosenblum, CI; MacNeil, T; Weinberg, DH; Peng, Q; Tamvakopoulos, C; Miller, RR; Stearns, RA; Cashen, DE; Martin, WJ; Metzger, JM; Strack, AM; MacIntyre, DE; Van der Ploeg, LH; Patchett, AA; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169442 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169442&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 6918851 104054247 CHEMBL364346 1337 ZINC14209775 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50142773 CC(C)C[C@H](N)c1cc(ccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)N1CCCC1=O)C(F)(F)F InChI=1S/C29H36ClF3N4O2/c1-19(2)16-24(34)23-18-21(29(31,32)33)7-10-25(23)35-12-14-36(15-13-35)28(39)26(37-11-3-4-27(37)38)17-20-5-8-22(30)9-6-20/h5-10,18-19,24,26H,3-4,11-17,34H2,1-2H3/t24-,26+/m0/s1 GWQJQMUYAJRYAV-AZGAKELHSA-N 50214685 1-[(R)-2-{4-[2-((S)-1-amino-3-methylbutyl)-4-trifluoromethylphenyl]-piperazin-1-yl}-1-(4-dichlorobenzyl)-2-oxoethyl]pyrrolidin-2-one::CHEMBL439560 Melanocortin receptor 4 Mus musculus 5.5 ChEMBL 10.1016/j.bmc.2007.05.026 10.7270/Q2FF3S2P 17544282 Tran, JA; Tucci, FC; Jiang, W; Marinkovic, D; Chen, CW; Arellano, M; Markison, S; Fleck, BA; Wen, J; White, NS; Pontillo, J; Saunders, J; Marks, D; Hoare, SR; Madan, A; Foster, AC; Chen, C Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214685&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 23661656 104089632 CHEMBL439560 ZINC28825773 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50145403 COc1ccc(CNCC2(CCCCC2)N2CCN(CC2)C(=O)[C@H]2CN(C[C@@H]2c2ccc(Cl)cc2)C(C)C)cc1F InChI=1S/C33H46ClFN4O2/c1-24(2)38-21-28(26-8-10-27(34)11-9-26)29(22-38)32(40)37-15-17-39(18-16-37)33(13-5-4-6-14-33)23-36-20-25-7-12-31(41-3)30(35)19-25/h7-12,19,24,28-29,36H,4-6,13-18,20-23H2,1-3H3/t28-,29+/m1/s1 UQIQXCRYYCAMIP-WDYNHAJCSA-N 50225589 (4-(1-((3-fluoro-4-methoxybenzylamino)methyl)cyclohexyl)piperazin-1-yl)((3R,4S)-4-(4-chlorophenyl)-1-isopropylpyrrolidin-3-yl)methanone::CHEMBL398929 Melanocortin receptor 4 Mus musculus 0.600000 ChEMBL 10.1016/j.bmcl.2007.10.032 10.7270/Q2862G5Z 17964151 Chen, CW; Tran, JA; Fleck, BA; Tucci, FC; Jiang, W; Chen, C Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50225589&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44443035 104096767 CHEMBL398929 ZINC28954011 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50145683 CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)N1CCCC1=O InChI=1S/C30H40Cl2FN5O2/c1-20(2)17-26(35-11-10-34)23-5-3-6-25(33)29(23)36-13-15-37(16-14-36)30(40)27(38-12-4-7-28(38)39)18-21-8-9-22(31)19-24(21)32/h3,5-6,8-9,19-20,26-27,35H,4,7,10-18,34H2,1-2H3/t26-,27+/m0/s1 CGANDSYNDFLFKG-RRPNLBNLSA-N 50221120 1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methylbutyl)-6-fluorophenyl)piperazin-1-yl)-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl)pyrrolidin-2-one::CHEMBL393576::N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrrolidinyl)-3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-3-fluorophenyl)-3-methylbutyl]amine Melanocortin receptor 4 Mus musculus 0.710000 ChEMBL 10.1021/jm701137s 10.7270/Q2P84BM9 17994683 Tran, JA; Jiang, W; Tucci, FC; Fleck, BA; Wen, J; Sai, Y; Madan, A; Chen, TK; Markison, S; Foster, AC; Hoare, SR; Marks, D; Harman, J; Chen, CW; Arellano, M; Marinkovic, D; Bozigian, H; Saunders, J; Chen, C Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50221120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50221120&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 24180646 104093809 CHEMBL393576 ZINC28823897 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50147816 CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1 InChI=1S/C29H40ClFN4O2/c1-20(2)27(32-26(36)13-14-33(4)5)24-7-6-8-25(31)28(24)34-15-17-35(18-16-34)29(37)21(3)19-22-9-11-23(30)12-10-22/h6-12,20-21,27H,13-19H2,1-5H3,(H,32,36)/t21-,27+/m1/s1 ROSDSGGMKIYLIM-ZBLYBZFDSA-N 50261195 1-{2-[(1S)-(3-Dimethylaminopropionamino)-2-methylpropyl]-6-fluorophenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine::CHEMBL497746 Melanocortin receptor 4 Mus musculus 3.5 ChEMBL 10.1016/j.bmc.2008.03.072 10.7270/Q2TX3F54 18417348 Chen, C; Tucci, FC; Jiang, W; Tran, JA; Fleck, BA; Hoare, SR; Wen, J; Chen, T; Johns, M; Markison, S; Foster, AC; Marinkovic, D; Chen, CW; Arellano, M; Harman, J; Saunders, J; Bozigian, H; Marks, D Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50261195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50261195&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44577060 104110404 CHEMBL497746 ZINC40975990 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50145691 CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1 InChI=1S/C30H42Cl2N4O2/c1-21(2)18-27(33-29(37)12-13-34(4)5)26-20-25(32)10-11-28(26)35-14-16-36(17-15-35)30(38)22(3)19-23-6-8-24(31)9-7-23/h6-11,20-22,27H,12-19H2,1-5H3,(H,33,37)/t22-,27+/m1/s1 NICHJJOSEXYBED-AMGIVPHBSA-N 50226629 CHEMBL266647::N-(1S-[2-{4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]-1-piperazinyl}-5-chlorophenyl]-3-methylbutyl)-3-(dimethylamino)propionamide Melanocortin receptor 4 Mus musculus 18 ChEMBL 10.1021/jm701137s 10.7270/Q2P84BM9 17994683 Tran, JA; Jiang, W; Tucci, FC; Fleck, BA; Wen, J; Sai, Y; Madan, A; Chen, TK; Markison, S; Foster, AC; Hoare, SR; Marks, D; Harman, J; Chen, CW; Arellano, M; Marinkovic, D; Bozigian, H; Saunders, J; Chen, C Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50226629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50226629&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 24180592 104097185 CHEMBL266647 ZINC28826793 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50144938 CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)N1CCCC1=O InChI=1S/C30H40Cl2FN5O2/c1-20(2)17-26(35-11-10-34)23-5-3-6-25(33)29(23)36-13-15-37(16-14-36)30(40)27(38-12-4-7-28(38)39)18-21-8-9-22(31)19-24(21)32/h3,5-6,8-9,19-20,26-27,35H,4,7,10-18,34H2,1-2H3/t26-,27+/m0/s1 CGANDSYNDFLFKG-RRPNLBNLSA-N 50221120 1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methylbutyl)-6-fluorophenyl)piperazin-1-yl)-3-(2,4-dichlorophenyl)-1-oxopropan-2-yl)pyrrolidin-2-one::CHEMBL393576::N-(1-aminoethyl)-N-[(1S)-(2-{4-[(2R)-(2-oxo-1-pyrrolidinyl)-3-(2,4-dichlorophenyl)propionyl]-1-piperazinyl}-3-fluorophenyl)-3-methylbutyl]amine Melanocortin receptor 4 Mus musculus 0.710000 ChEMBL 10.1016/j.bmcl.2007.07.097 10.7270/Q2XK8F8V 17822895 Jiang, W; Tucci, FC; Tran, JA; Fleck, BA; Wen, J; Markison, S; Marinkovic, D; Chen, CW; Arellano, M; Hoare, SR; Johns, M; Foster, AC; Saunders, J; Chen, C Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50221120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50221120&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 24180646 104093809 CHEMBL393576 ZINC28823897 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50145295 CC(C)[C@H](NC(=O)CCN(C)C)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1 InChI=1S/C30H43ClN4O2/c1-21(2)29(32-28(36)13-14-33(5)6)26-19-22(3)7-12-27(26)34-15-17-35(18-16-34)30(37)23(4)20-24-8-10-25(31)11-9-24/h7-12,19,21,23,29H,13-18,20H2,1-6H3,(H,32,36)/t23-,29+/m1/s1 FRHBHVROLQSPMW-BTYSJIOQSA-N 50224181 1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methylpropyl]-4-methylphenyl}-4-[(2R)-methyl-3-(4-chlorophenyl)propionyl]piperazine::CHEMBL427860::N-((S)-1-(2-(4-((R)-3-(4-chlorophenyl)-2-methylpropanoyl)piperazin-1-yl)-5-methylphenyl)-2-methylpropyl)-3-(dimethylamino)propanamide Melanocortin receptor 4 Mus musculus 3.2 ChEMBL 10.1021/jm070806a 10.7270/Q29C6X6B 17918824 Chen, C; Jiang, W; Tucci, F; Tran, JA; Fleck, BA; Hoare, SR; Joppa, M; Markison, S; Wen, J; Sai, Y; Johns, M; Madan, A; Chen, T; Chen, CW; Marinkovic, D; Arellano, M; Saunders, J; Foster, AC Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50224181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50224181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 23635235 104095909 CHEMBL427860 ZINC28867163 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160033 NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N(Cc2ccccc2)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C43H53N11O7/c44-36(55)26-53-21-20-47-37(56)17-18-38(57)51-34(22-28-10-3-1-4-11-28)42(61)54(25-29-12-5-2-6-13-29)27-39(58)50-33(16-9-19-48-43(45)46)40(59)52-35(41(53)60)23-30-24-49-32-15-8-7-14-31(30)32/h1-8,10-15,24,33-35,49H,9,16-23,25-27H2,(H2,44,55)(H,47,56)(H,50,58)(H,51,57)(H,52,59)(H4,45,46,48)/t33-,34-,35-/m0/s1 HJUBFBDOZXYEPW-IMKBVMFZSA-N 50310320 2-((6S,9S,15S)-6-((1H-indol-3-yl)methyl)-13,15-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,20-hexaoxo-1,4,7,10,13,16-hexaazacycloicosan-4-yl)acetamide::CHEMBL589516 Melanocortin receptor 4 Mus musculus 3830 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310320&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232221 104144681 CHEMBL589516 ZINC95543258 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160036 NC(=O)CN1CCNC(=O)CCC(=O)N(Cc2ccccc2)CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C43H53N11O7/c44-36(55)26-53-21-20-47-37(56)17-18-39(58)54(25-29-12-5-2-6-13-29)27-38(57)50-34(22-28-10-3-1-4-11-28)41(60)51-33(16-9-19-48-43(45)46)40(59)52-35(42(53)61)23-30-24-49-32-15-8-7-14-31(30)32/h1-8,10-15,24,33-35,49H,9,16-23,25-27H2,(H2,44,55)(H,47,56)(H,50,57)(H,51,60)(H,52,59)(H4,45,46,48)/t33-,34+,35-/m0/s1 ORYWRHNGBVOBHL-XFQWPLCWSA-N 50310321 2-((6S,9S,12R)-6-((1H-indol-3-yl)methyl)-12,16-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,20-hexaoxo-1,4,7,10,13,16-hexaazacycloicosan-4-yl)acetamide::CHEMBL602652 Melanocortin receptor 4 Mus musculus 1370 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310321&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232220 104144682 CHEMBL602652 ZINC95537508 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160038 CC(=O)NCC(=O)N(CC(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)Cc1ccccc1)Cc1ccccc1 InChI=1S/C41H51N11O7/c1-27(53)46-22-37(56)52(24-29-13-6-3-7-14-29)26-38(57)51(23-28-11-4-2-5-12-28)25-36(55)49-33(17-10-18-45-41(43)44)40(59)50-34(39(58)48-21-35(42)54)19-30-20-47-32-16-9-8-15-31(30)32/h2-9,11-16,20,33-34,47H,10,17-19,21-26H2,1H3,(H2,42,54)(H,46,53)(H,48,58)(H,49,55)(H,50,59)(H4,43,44,45)/t33-,34-/m0/s1 UENCACMFJICPLI-HEVIKAOCSA-N 50310326 (S)-2-(2-(2-(2-acetamido-N-benzylacetamido)-N-benzylacetamido)acetamido)-N-((S)-1-(2-amino-2-oxoethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide::CHEMBL589308 Melanocortin receptor 4 Mus musculus 11 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310326&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232219 104144687 CHEMBL589308 ZINC95537459 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160039 CC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)Cc1ccccc1 InChI=1S/C41H51N11O7/c1-26(53)46-23-36(55)50-34(19-27-11-4-2-5-12-27)40(59)52(24-28-13-6-3-7-14-28)25-37(56)49-32(17-10-18-45-41(43)44)39(58)51-33(38(57)48-22-35(42)54)20-29-21-47-31-16-9-8-15-30(29)31/h2-9,11-16,21,32-34,47H,10,17-20,22-25H2,1H3,(H2,42,54)(H,46,53)(H,48,57)(H,49,56)(H,50,55)(H,51,58)(H4,43,44,45)/t32-,33-,34-/m0/s1 NNWTYMHQMMPOOT-AFEGWXKPSA-N 50310322 (S)-2-(2-((S)-2-(2-acetamidoacetamido)-N-benzyl-3-phenylpropanamido)acetamido)-N-((S)-1-(2-amino-2-oxoethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide::CHEMBL602651 Melanocortin receptor 4 Mus musculus 8.8 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310322&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232218 104144683 CHEMBL602651 ZINC95537507 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160042 CC(=O)NCC(=O)N(CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O)Cc1ccccc1 InChI=1S/C41H51N11O7/c1-26(53)46-23-37(56)52(24-28-13-6-3-7-14-28)25-36(55)49-33(19-27-11-4-2-5-12-27)40(59)50-32(17-10-18-45-41(43)44)39(58)51-34(38(57)48-22-35(42)54)20-29-21-47-31-16-9-8-15-30(29)31/h2-9,11-16,21,32-34,47H,10,17-20,22-25H2,1H3,(H2,42,54)(H,46,53)(H,48,57)(H,49,55)(H,50,59)(H,51,58)(H4,43,44,45)/t32-,33+,34-/m0/s1 YBYMKNFNNNSTAX-GMTSZFNJSA-N 50310323 (S)-2-((R)-2-(2-(2-acetamido-N-benzylacetamido)acetamido)-3-phenylpropanamido)-N-((S)-1-(2-amino-2-oxoethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-5-guanidinopentanamide::CHEMBL602650 Melanocortin receptor 4 Mus musculus 9820 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310323&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232217 104144684 CHEMBL602650 ZINC95537506 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160048 N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H43N9O4/c36-26(18-22-10-3-1-4-11-22)32(46)44-30(19-23-12-5-2-6-13-23)34(48)42-28(16-9-17-40-35(38)39)33(47)43-29(31(37)45)20-24-21-41-27-15-8-7-14-25(24)27/h1-8,10-15,21,26,28-30,41H,9,16-20,36H2,(H2,37,45)(H,42,48)(H,43,47)(H,44,46)(H4,38,39,40)/t26-,28-,29-,30+/m0/s1 NYOUWNQJCVZGBR-ZVVXMFRTSA-N 50310324 CHEMBL589515::Phe-D-Phe-Arg-Trp-NH2 Melanocortin receptor 4 Mus musculus 71 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310324&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11411207 104144685 CHEMBL589515 ZINC49746266 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160049 NC(=O)CN1CCNC(=O)CCC(=O)N(Cc2ccccc2)CC(=O)N(Cc2ccccc2)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C43H53N11O7/c44-36(55)26-52-21-20-47-37(56)17-18-39(58)54(25-30-12-5-2-6-13-30)28-40(59)53(24-29-10-3-1-4-11-29)27-38(57)50-34(16-9-19-48-43(45)46)41(60)51-35(42(52)61)22-31-23-49-33-15-8-7-14-32(31)33/h1-8,10-15,23,34-35,49H,9,16-22,24-28H2,(H2,44,55)(H,47,56)(H,50,57)(H,51,60)(H4,45,46,48)/t34-,35-/m0/s1 XVDUHIYVXSMUJO-PXLJZGITSA-N 50310319 2-((6S,9S)-6-((1H-indol-3-yl)methyl)-13,16-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,20-hexaoxo-1,4,7,10,13,16-hexaazacycloicosan-4-yl)acetamide::CHEMBL602653 Melanocortin receptor 4 Mus musculus 1960 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310319&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232222 104144680 CHEMBL602653 ZINC95543416 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160050 NC(=O)CN1CCNC(=O)CCCCC(=O)N(Cc2ccccc2)CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C45H57N11O7/c46-38(57)28-55-23-22-49-39(58)19-9-10-20-41(60)56(27-31-14-5-2-6-15-31)29-40(59)52-36(24-30-12-3-1-4-13-30)43(62)53-35(18-11-21-50-45(47)48)42(61)54-37(44(55)63)25-32-26-51-34-17-8-7-16-33(32)34/h1-8,12-17,26,35-37,51H,9-11,18-25,27-29H2,(H2,46,57)(H,49,58)(H,52,59)(H,53,62)(H,54,61)(H4,47,48,50)/t35-,36+,37-/m0/s1 KJIJKOIUSIULPV-QOEXFKEZSA-N 50310325 2-((6S,9S,12R)-6-((1H-indol-3-yl)methyl)-12,16-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,22-hexaoxo-1,4,7,10,13,16-hexaazacyclodocosan-4-yl)acetamide::CHEMBL602853 Melanocortin receptor 4 Mus musculus 49 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310325&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232226 104144686 CHEMBL602853 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160052 NC(=O)CN1CCNC(=O)CCCC(=O)N(Cc2ccccc2)CC(=O)N(Cc2ccccc2)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C44H55N11O7/c45-37(56)27-53-22-21-48-38(57)18-9-19-40(59)55(26-31-13-5-2-6-14-31)29-41(60)54(25-30-11-3-1-4-12-30)28-39(58)51-35(17-10-20-49-44(46)47)42(61)52-36(43(53)62)23-32-24-50-34-16-8-7-15-33(32)34/h1-8,11-16,24,35-36,50H,9-10,17-23,25-29H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H4,46,47,49)/t35-,36-/m0/s1 SMOLPOMQFBNJFJ-ZPGRZCPFSA-N 50310316 2-((6S,9S)-6-((1H-indol-3-yl)methyl)-13,16-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,21-hexaoxo-1,4,7,10,13,16-hexaazacyclohenicosan-4-yl)acetamide::CHEMBL602852 Melanocortin receptor 4 Mus musculus 2250 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310316&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232225 104144677 CHEMBL602852 ZINC95537967 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160058 NC(=O)CN1CCNC(=O)CCCC(=O)N(Cc2ccccc2)CC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C44H55N11O7/c45-37(56)27-54-22-21-48-38(57)18-9-19-40(59)55(26-30-13-5-2-6-14-30)28-39(58)51-35(23-29-11-3-1-4-12-29)42(61)52-34(17-10-20-49-44(46)47)41(60)53-36(43(54)62)24-31-25-50-33-16-8-7-15-32(31)33/h1-8,11-16,25,34-36,50H,9-10,17-24,26-28H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H4,46,47,49)/t34-,35+,36-/m0/s1 DVNWJYATAPNBQI-PDHQKIGBSA-N 50310318 2-((6S,9S,12R)-6-((1H-indol-3-yl)methyl)-12,16-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,21-hexaoxo-1,4,7,10,13,16-hexaazacyclohenicosan-4-yl)acetamide::CHEMBL589468 Melanocortin receptor 4 Mus musculus 640 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310318&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232223 104144679 CHEMBL589468 ZINC95537458 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160066 NC(=O)CN1CCNC(=O)CCCCC(=O)N(Cc2ccccc2)CC(=O)N(Cc2ccccc2)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C45H57N11O7/c46-38(57)28-54-23-22-49-39(58)19-9-10-20-41(60)56(27-32-14-5-2-6-15-32)30-42(61)55(26-31-12-3-1-4-13-31)29-40(59)52-36(18-11-21-50-45(47)48)43(62)53-37(44(54)63)24-33-25-51-35-17-8-7-16-34(33)35/h1-8,12-17,25,36-37,51H,9-11,18-24,26-30H2,(H2,46,57)(H,49,58)(H,52,59)(H,53,62)(H4,47,48,50)/t36-,37-/m0/s1 IFVMGZUEGABMFC-BCRBLDSWSA-N 50310314 2-((6S,9S)-6-((1H-indol-3-yl)methyl)-13,16-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,22-hexaoxo-1,4,7,10,13,16-hexaazacyclodocosan-4-yl)acetamide::CHEMBL602299 Melanocortin receptor 4 Mus musculus 1700 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310314&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232228 104144675 CHEMBL602299 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50160067 NC(=O)CN1CCNC(=O)CCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N(Cc2ccccc2)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C45H57N11O7/c46-38(57)28-55-23-22-49-39(58)19-9-10-20-40(59)53-36(24-30-12-3-1-4-13-30)44(63)56(27-31-14-5-2-6-15-31)29-41(60)52-35(18-11-21-50-45(47)48)42(61)54-37(43(55)62)25-32-26-51-34-17-8-7-16-33(32)34/h1-8,12-17,26,35-37,51H,9-11,18-25,27-29H2,(H2,46,57)(H,49,58)(H,52,60)(H,53,59)(H,54,61)(H4,47,48,50)/t35-,36-,37-/m0/s1 UFTHOJUCAJELPF-FSEITFBQSA-N 50310315 2-((6S,9S,15S)-6-((1H-indol-3-yl)methyl)-13,15-dibenzyl-9-(3-guanidinopropyl)-5,8,11,14,17,22-hexaoxo-1,4,7,10,13,16-hexaazacyclodocosan-4-yl)acetamide::CHEMBL589517 Melanocortin receptor 4 Mus musculus 3300 ChEMBL 10.1016/j.bmc.2009.12.010 10.7270/Q20Z73C3 20056544 Ovadia, O; Linde, Y; Haskell-Luevano, C; Dirain, ML; Sheynis, T; Jelinek, R; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50310315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50310315&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46232227 104144676 CHEMBL589517 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50172077 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H94N20O15S3/c1-42-67(103)90-56(29-43-11-4-2-5-12-43)70(106)96-62(74(110)89-55(66(80)102)28-46-20-24-51(99)25-21-46)39-115-114-38-61(94-68(104)53(78)27-45-18-22-50(98)23-19-45)75(111)92-58(32-49-35-83-41-86-49)72(108)91-57(30-44-13-6-3-7-14-44)71(107)95-60-37-113-40-65(101)97(36-48(88-73(60)109)15-10-26-84-77(81)82)63(31-47-34-85-54-17-9-8-16-52(47)54)76(112)93-59(33-64(79)100)69(105)87-42/h2-9,11-14,16-25,34-35,41-42,48,53,55-63,85,98-99H,10,15,26-33,36-40,78H2,1H3,(H2,79,100)(H2,80,102)(H,83,86)(H,87,105)(H,88,109)(H,89,110)(H,90,103)(H,91,108)(H,92,111)(H,93,112)(H,94,104)(H,95,107)(H,96,106)(H4,81,82,84)/t42-,48-,53-,55-,56-,57+,58-,59-,60-,61-,62-,63-/m0/s1 SAUMKWJPJZDAEN-CNEXOMJLSA-N 50339346 (R)-trans-(2S,5S,8S,11S,14R,19R,22S,25R,28R,31S)-22-((1H-imidazol-5-yl)methyl)-2-((1H-indol-3-yl)methyl)-5-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-19-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-11,25-dibenzyl-31-(3-guanidinopropyl)-8-methyl-3,6,9,12,20,23,26,29,33-nonaoxo-16,17,35-trithia-1,4,7,10,13,21,24,27,30-nonaazabicyclo[26.4.4]hexatriacontane-14-carboxamide::CHEMBL1688110 Melanocortin receptor 4 Mus musculus 85 ChEMBL 10.1021/jm101425m 10.7270/Q2FB537C 21306168 Singh, A; Wilczynski, A; Holder, JR; Witek, RM; Dirain, ML; Xiang, Z; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339346&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932359 125089448 CHEMBL1688110 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50172079 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H94N20O15S3/c1-42-67(103)90-56(29-43-11-4-2-5-12-43)70(106)96-62(74(110)89-55(66(80)102)28-46-20-24-51(99)25-21-46)39-115-114-38-61(94-68(104)53(78)27-45-18-22-50(98)23-19-45)75(111)92-58(32-49-35-83-41-86-49)72(108)91-57(30-44-13-6-3-7-14-44)71(107)95-60-37-113-40-65(101)97(36-48(88-73(60)109)15-10-26-84-77(81)82)63(31-47-34-85-54-17-9-8-16-52(47)54)76(112)93-59(33-64(79)100)69(105)87-42/h2-9,11-14,16-25,34-35,41-42,48,53,55-63,85,98-99H,10,15,26-33,36-40,78H2,1H3,(H2,79,100)(H2,80,102)(H,83,86)(H,87,105)(H,88,109)(H,89,110)(H,90,103)(H,91,108)(H,92,111)(H,93,112)(H,94,104)(H,95,107)(H,96,106)(H4,81,82,84)/t42-,48-,53-,55-,56-,57+,58-,59-,60+,61-,62-,63-/m0/s1 SAUMKWJPJZDAEN-FHILOCCJSA-N 50339347 (S)-cis-(2S,5S,8S,11S,14R,19R,22S,25R,28S,31S)-22-((1H-imidazol-5-yl)methyl)-2-((1H-indol-3-yl)methyl)-5-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-19-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-11,25-dibenzyl-31-(3-guanidinopropyl)-8-methyl-3,6,9,12,20,23,26,29,33-nonaoxo-16,17,35-trithia-1,4,7,10,13,21,24,27,30-nonaazabicyclo[26.4.4]hexatriacontane-14-carboxamide::CHEMBL1688111 Melanocortin receptor 4 Mus musculus 780 ChEMBL 10.1021/jm101425m 10.7270/Q2FB537C 21306168 Singh, A; Wilczynski, A; Holder, JR; Witek, RM; Dirain, ML; Xiang, Z; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339347&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932360 125089449 CHEMBL1688111 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50172081 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C72H87N19O14S2/c1-39-62(96)85-53(29-40-11-4-2-5-12-40)67(101)91-59(70(104)84-52(61(75)95)28-43-20-24-47(93)25-21-43)37-107-106-36-58(90-63(97)49(73)27-42-18-22-46(92)23-19-42)71(105)88-56(32-45-35-78-38-81-45)69(103)86-54(30-41-13-6-3-7-14-41)66(100)83-51(17-10-26-79-72(76)77)64(98)87-55(31-44-34-80-50-16-9-8-15-48(44)50)68(102)89-57(33-60(74)94)65(99)82-39/h2-9,11-16,18-25,34-35,38-39,49,51-59,80,92-93H,10,17,26-33,36-37,73H2,1H3,(H2,74,94)(H2,75,95)(H,78,81)(H,82,99)(H,83,100)(H,84,104)(H,85,96)(H,86,103)(H,87,98)(H,88,105)(H,89,102)(H,90,97)(H,91,101)(H4,76,77,79)/t39-,49-,51-,52-,53-,54+,55-,56-,57-,58-,59-/m0/s1 VEIBXMZRLHAMLO-LANMVBEMSA-N 50339348 (4R,7S,10S,13S,16S,19S,22R,25S,28R)-25-((1H-imidazol-4-yl)methyl)-16-((1H-indol-3-yl)methyl)-13-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-28-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-7,22-dibenzyl-19-(3-guanidinopropyl)-10-methyl-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxamide::CHEMBL1688107 Melanocortin receptor 4 Mus musculus 0.270000 ChEMBL 10.1021/jm101425m 10.7270/Q2FB537C 21306168 Singh, A; Wilczynski, A; Holder, JR; Witek, RM; Dirain, ML; Xiang, Z; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339348&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932361 125089450 CHEMBL1688107 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50172084 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H]1CSCC(=O)N(C[C@H](CCCN=C(N)N)NC1=O)[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C39H50N12O6S/c1-23(52)47-31(16-27-18-43-22-46-27)37(56)49-30(14-24-8-3-2-4-9-24)36(55)50-32-20-58-21-34(53)51(19-26(48-38(32)57)10-7-13-44-39(41)42)33(35(40)54)15-25-17-45-29-12-6-5-11-28(25)29/h2-6,8-9,11-12,17-18,22,26,30-33,45H,7,10,13-16,19-21H2,1H3,(H2,40,54)(H,43,46)(H,47,52)(H,48,57)(H,49,56)(H,50,55)(H4,41,42,44)/t26-,30+,31-,32+,33-/m0/s1 DPRUDGOHUWTPRM-KELWCDABSA-N 50339349 (S)-2-acetamido-N-((R)-1-((6S,9S)-4-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-6-(3-guanidinopropyl)-3,8-dioxo-1,4,7-thiadiazecan-9-ylamino)-1-oxo-3-phenylpropan-2-yl)-3-(1H-imidazol-4-yl)propanamide::CHEMBL1688108 Melanocortin receptor 4 Mus musculus 650 ChEMBL 10.1021/jm101425m 10.7270/Q2FB537C 21306168 Singh, A; Wilczynski, A; Holder, JR; Witek, RM; Dirain, ML; Xiang, Z; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339349&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 53318436 125089451 CHEMBL1688108 ZINC95547374 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50172087 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.200000 ChEMBL 10.1021/jm101425m 10.7270/Q2FB537C 21306168 Singh, A; Wilczynski, A; Holder, JR; Witek, RM; Dirain, ML; Xiang, Z; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50172089 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H94N20O15S3/c1-42-67(103)90-56(30-44-13-6-3-7-14-44)70(106)96-62(74(110)89-55(66(80)102)29-46-20-24-51(99)25-21-46)39-115-114-38-61(94-68(104)53(78)28-45-18-22-50(98)23-19-45)75(111)91-58(32-48-35-83-41-86-48)72(108)95-60-37-113-40-65(101)97(36-49(88-73(60)109)27-43-11-4-2-5-12-43)63(17-10-26-84-77(81)82)76(112)93-57(31-47-34-85-54-16-9-8-15-52(47)54)71(107)92-59(33-64(79)100)69(105)87-42/h2-9,11-16,18-25,34-35,41-42,49,53,55-63,85,98-99H,10,17,26-33,36-40,78H2,1H3,(H2,79,100)(H2,80,102)(H,83,86)(H,87,105)(H,88,109)(H,89,110)(H,90,103)(H,91,111)(H,92,107)(H,93,112)(H,94,104)(H,95,108)(H,96,106)(H4,81,82,84)/t42-,49+,53-,55-,56-,57-,58-,59-,60-,61-,62-,63-/m0/s1 LDYAQMAQKPCOKX-KAILQHMVSA-N 50339344 (R)-trans-(2S,5S,8S,11S,14S,17S,22R,25S,28R,31R)-25-((1H-imidazol-5-yl)methyl)-5-((1H-indol-3-yl)methyl)-8-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-22-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-14,31-dibenzyl-2-(3-guanidinopropyl)-11-methyl-3,6,9,12,15,23,26,29,33-nonaoxo-19,20,35-trithia-1,4,7,10,13,16,24,27,30-nonaazabicyclo[26.4.4]hexatriacontane-17-carboxamide::CHEMBL1688109 Melanocortin receptor 4 Mus musculus 2730 ChEMBL 10.1021/jm101425m 10.7270/Q2FB537C 21306168 Singh, A; Wilczynski, A; Holder, JR; Witek, RM; Dirain, ML; Xiang, Z; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339344&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932357 125089446 CHEMBL1688109 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50172093 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CSCC2=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H94N20O15S3/c1-42-67(103)91-57(29-43-11-4-2-5-12-43)71(107)96-62(74(110)90-56(66(80)102)28-46-20-24-51(99)25-21-46)39-115-114-38-61(94-68(104)53(78)27-45-18-22-50(98)23-19-45)75(111)95-60-37-113-40-65(101)97(36-49(88-73(60)109)32-48-35-83-41-86-48)63(30-44-13-6-3-7-14-44)76(112)89-55(17-10-26-84-77(81)82)69(105)92-58(31-47-34-85-54-16-9-8-15-52(47)54)72(108)93-59(33-64(79)100)70(106)87-42/h2-9,11-16,18-25,34-35,41-42,49,53,55-63,85,98-99H,10,17,26-33,36-40,78H2,1H3,(H2,79,100)(H2,80,102)(H,83,86)(H,87,106)(H,88,109)(H,89,112)(H,90,110)(H,91,103)(H,92,105)(H,93,108)(H,94,104)(H,95,111)(H,96,107)(H4,81,82,84)/t42-,49-,53-,55-,56-,57-,58-,59-,60-,61-,62-,63+/m0/s1 LJABAIOSDNQOHO-FBOVWTABSA-N 50339350 (R)-trans-(2R,5S,8S,11S,14S,17S,20R,25R,28R,31S)-31-((1H-imidazol-5-yl)methyl)-8-((1H-indol-3-yl)methyl)-11-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-25-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-2,17-dibenzyl-5-(3-guanidinopropyl)-14-methyl-3,6,9,12,15,18,26,29,33-nonaoxo-22,23,35-trithia-1,4,7,10,13,16,19,27,30-nonaazabicyclo[26.4.4]hexatriacontane-20-carboxamide::CHEMBL1688104 Melanocortin receptor 4 Mus musculus 350 ChEMBL 10.1021/jm101425m 10.7270/Q2FB537C 21306168 Singh, A; Wilczynski, A; Holder, JR; Witek, RM; Dirain, ML; Xiang, Z; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339350&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932362 125089452 CHEMBL1688104 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50172095 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)N2C[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H94N20O15S3/c1-42-67(103)91-57(29-43-11-4-2-5-12-43)71(107)96-62(74(110)90-56(66(80)102)28-46-20-24-51(99)25-21-46)39-115-114-38-61(94-68(104)53(78)27-45-18-22-50(98)23-19-45)75(111)95-60-37-113-40-65(101)97(36-49(88-73(60)109)32-48-35-83-41-86-48)63(30-44-13-6-3-7-14-44)76(112)89-55(17-10-26-84-77(81)82)69(105)92-58(31-47-34-85-54-16-9-8-15-52(47)54)72(108)93-59(33-64(79)100)70(106)87-42/h2-9,11-16,18-25,34-35,41-42,49,53,55-63,85,98-99H,10,17,26-33,36-40,78H2,1H3,(H2,79,100)(H2,80,102)(H,83,86)(H,87,106)(H,88,109)(H,89,112)(H,90,110)(H,91,103)(H,92,105)(H,93,108)(H,94,104)(H,95,111)(H,96,107)(H4,81,82,84)/t42-,49-,53-,55-,56-,57-,58-,59-,60+,61-,62-,63+/m0/s1 LJABAIOSDNQOHO-AGOVHYEISA-N 50339343 (S)-cis-(2R,5S,8S,11S,14S,17S,20R,25R,28S,31S)-31-((1H-imidazol-5-yl)methyl)-8-((1H-indol-3-yl)methyl)-11-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-25-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-2,17-dibenzyl-5-(3-guanidinopropyl)-14-methyl-3,6,9,12,15,18,26,29,33-nonaoxo-22,23,35-trithia-1,4,7,10,13,16,19,27,30-nonaazabicyclo[26.4.4]hexatriacontane-20-carboxamide::CHEMBL1688105 Melanocortin receptor 4 Mus musculus 3060 ChEMBL 10.1021/jm101425m 10.7270/Q2FB537C 21306168 Singh, A; Wilczynski, A; Holder, JR; Witek, RM; Dirain, ML; Xiang, Z; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339343&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932356 125089445 CHEMBL1688105 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50172097 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)N2C[C@@H](Cc3ccccc3)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H94N20O15S3/c1-42-67(103)90-56(30-44-13-6-3-7-14-44)70(106)96-62(74(110)89-55(66(80)102)29-46-20-24-51(99)25-21-46)39-115-114-38-61(94-68(104)53(78)28-45-18-22-50(98)23-19-45)75(111)91-58(32-48-35-83-41-86-48)72(108)95-60-37-113-40-65(101)97(36-49(88-73(60)109)27-43-11-4-2-5-12-43)63(17-10-26-84-77(81)82)76(112)93-57(31-47-34-85-54-16-9-8-15-52(47)54)71(107)92-59(33-64(79)100)69(105)87-42/h2-9,11-16,18-25,34-35,41-42,49,53,55-63,85,98-99H,10,17,26-33,36-40,78H2,1H3,(H2,79,100)(H2,80,102)(H,83,86)(H,87,105)(H,88,109)(H,89,110)(H,90,103)(H,91,111)(H,92,107)(H,93,112)(H,94,104)(H,95,108)(H,96,106)(H4,81,82,84)/t42-,49+,53-,55-,56-,57-,58-,59-,60+,61-,62-,63-/m0/s1 LDYAQMAQKPCOKX-JRSPOBCWSA-N 50339345 (S)-cis-(2S,5S,8S,11S,14S,17S,22R,25S,28S,31R)-25-((1H-imidazol-5-yl)methyl)-5-((1H-indol-3-yl)methyl)-8-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-22-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-14,31-dibenzyl-2-(3-guanidinopropyl)-11-methyl-3,6,9,12,15,23,26,29,33-nonaoxo-19,20,35-trithia-1,4,7,10,13,16,24,27,30-nonaazabicyclo[26.4.4]hexatriacontane-17-carboxamide::CHEMBL1688106 Melanocortin receptor 4 Mus musculus 3210 ChEMBL 10.1021/jm101425m 10.7270/Q2FB537C 21306168 Singh, A; Wilczynski, A; Holder, JR; Witek, RM; Dirain, ML; Xiang, Z; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339345&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932358 125089447 CHEMBL1688106 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50161580 CC(=O)NC(C)(C)[C@@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 InChI=1S/C34H44ClF2N3O2/c1-20-14-24-27(16-29(20)35)34(17-28(24)33(6,7)38-21(2)41)10-12-39(13-11-34)31(42)26-19-40(32(3,4)5)18-25(26)23-9-8-22(36)15-30(23)37/h8-9,14-16,25-26,28H,10-13,17-19H2,1-7H3,(H,38,41)/t25-,26+,28+/m0/s1 KMNARKQYUZICHM-ZRRKCSAHSA-N 50314764 CHEMBL1093304::trans-N-(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)propan-2-yl)acetamide Melanocortin receptor 4 Mus musculus 22 ChEMBL 10.1016/j.bmcl.2010.02.058 10.7270/Q2QC03NP 20207541 He, S; Ye, Z; Dobbelaar, PH; Sebhat, IK; Guo, L; Liu, J; Jian, T; Lai, Y; Franklin, CL; Bakshi, RK; Dellureficio, JP; Hong, Q; Tsou, NN; Ball, RG; Cashen, DE; Martin, WJ; Weinberg, DH; Macneil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Miller, RR; Stearns, RA; Chen, HY; Chen, AS; Strack, AM; Fong, TM; Macintyre, DE; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314764&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11753695 104149125 CHEMBL1093304 ZINC49781164 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50164128 Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]3CN(C[C@H]3c3ccc(F)cc3F)C3CCOCC3)c2cc1Cl)C(C)(C)C#N InChI=1S/C33H38ClF2N3O3/c1-20-14-24-27(16-28(20)34)33(42-30(24)32(2,3)19-37)8-10-38(11-9-33)31(40)26-18-39(22-6-12-41-13-7-22)17-25(26)23-5-4-21(35)15-29(23)36/h4-5,14-16,22,25-26,30H,6-13,17-18H2,1-3H3/t25-,26+,30-/m0/s1 BCFFSQJVHOEAAU-MWSYKCOMSA-N 50323441 2-((S)-6-chloro-1'-((3S,4R)-4-(2,4-difluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)pyrrolidine-3-carbonyl)-5-methyl-3H-spiro[isobenzofuran-1,4'-piperidine]-3-yl)-2-methylpropanenitrile::CHEMBL1209788 Melanocortin receptor 4 Mus musculus 3.4 ChEMBL 10.1016/j.bmcl.2010.06.068 10.7270/Q2TB172P 20621473 Guo, L; Ye, Z; Liu, J; He, S; Bakshi, RK; Sebhat, IK; Dobbelaar, PH; Hong, Q; Jian, T; Dellureficio, JP; Tsou, NN; Ball, RG; Weinberg, DH; MacNeil, T; Tang, R; Tamvakopoulos, C; Peng, Q; Chen, HY; Chen, AS; Martin, WJ; MacIntyre, DE; Strack, AM; Fong, TM; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50323441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50323441&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 46919520 117644762 CHEMBL1209788 ZINC58582788 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50205830 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.290000 ChEMBL 10.1021/jm030452x 10.7270/Q2XP75PK 14998337 Han, G; Haskell-Luevano, C; Kendall, L; Bonner, G; Hadley, ME; Cone, RD; Hruby, VJ University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245333 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O 50027084 Melatonan Melanocortin receptor 4 Mus musculus 0.060000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50027084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50027084&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 92432 277286650 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245334 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(CC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 50031469 CHEMBL3358552 Melanocortin receptor 4 Mus musculus 0.067000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031469&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722944 313066067 CHEMBL3358552 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245335 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(CC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 50031470 CHEMBL3358551 Melanocortin receptor 4 Mus musculus 0.140000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031470&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722943 313066068 CHEMBL3358551 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245336 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cn2cc(CCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 50031471 CHEMBL3358550 Melanocortin receptor 4 Mus musculus 0.140000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031471&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722942 313066069 CHEMBL3358550 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245337 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCn2cc(CCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 50031473 CHEMBL3358549 Melanocortin receptor 4 Mus musculus 0.048000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031473&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722941 103940104 CHEMBL3358549 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245338 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCn2cc(CC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 InChI=1S/C51H69N17O8/c1-3-4-15-38(59-30(2)69)45(71)61-40-18-11-22-68-28-33(66-67-68)19-20-37(44(52)70)60-49(75)42(24-32-26-57-36-16-9-8-14-35(32)36)64-46(72)39(17-10-21-56-51(53)54)62-48(74)41(23-31-12-6-5-7-13-31)63-50(76)43(65-47(40)73)25-34-27-55-29-58-34/h5-9,12-14,16,26-29,37-43,57H,3-4,10-11,15,17-25H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,75)(H,61,71)(H,62,74)(H,63,76)(H,64,72)(H,65,73)(H4,53,54,56)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 QILKOMANHAGCIP-PMHRFVFWSA-N 50031476 CHEMBL3358548 Melanocortin receptor 4 Mus musculus 0.850000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031476&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722940 103940107 CHEMBL3358548 ZINC34633724 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245339 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCn2cc(C[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 InChI=1S/C51H69N17O8/c1-3-4-16-37(59-30(2)69)45(71)60-38-18-10-11-21-68-28-34(66-67-68)25-40(44(52)70)62-49(75)42(23-32-26-57-36-17-9-8-15-35(32)36)64-47(73)39(19-12-20-56-51(53)54)61-48(74)41(22-31-13-6-5-7-14-31)63-50(76)43(65-46(38)72)24-33-27-55-29-58-33/h5-9,13-15,17,26-29,37-43,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,71)(H,61,74)(H,62,75)(H,63,76)(H,64,73)(H,65,72)(H4,53,54,56)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 PIOLFYWBAQKAOU-PMHRFVFWSA-N 50031477 CHEMBL3358547 Melanocortin receptor 4 Mus musculus 0.580000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031477&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722939 103940108 CHEMBL3358547 ZINC34633728 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245340 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCCc2cn(C[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 InChI=1S/C51H69N17O8/c1-3-4-17-37(59-30(2)69)45(71)60-38-19-10-8-15-33-27-68(67-66-33)28-43(44(52)70)65-49(75)41(23-32-25-57-36-18-11-9-16-35(32)36)63-47(73)39(20-12-21-56-51(53)54)61-48(74)40(22-31-13-6-5-7-14-31)62-50(76)42(64-46(38)72)24-34-26-55-29-58-34/h5-7,9,11,13-14,16,18,25-27,29,37-43,57H,3-4,8,10,12,15,17,19-24,28H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,71)(H,61,74)(H,62,76)(H,63,73)(H,64,72)(H,65,75)(H4,53,54,56)/t37-,38-,39-,40+,41-,42-,43-/m0/s1 YMFIKOFGKXEQLT-ZRBRQIMBSA-N 50031478 CHEMBL3358546 Melanocortin receptor 4 Mus musculus 0.140000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031478&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722938 103940109 CHEMBL3358546 ZINC34633732 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245341 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCCc2cn(CC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 InChI=1S/C51H69N17O8/c1-3-4-16-38(59-30(2)69)45(71)61-39-18-10-14-33-28-68(67-66-33)22-20-37(44(52)70)60-49(75)42(24-32-26-57-36-17-9-8-15-35(32)36)64-47(73)40(19-11-21-56-51(53)54)62-48(74)41(23-31-12-6-5-7-13-31)63-50(76)43(65-46(39)72)25-34-27-55-29-58-34/h5-9,12-13,15,17,26-29,37-43,57H,3-4,10-11,14,16,18-25H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,75)(H,61,71)(H,62,74)(H,63,76)(H,64,73)(H,65,72)(H4,53,54,56)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 OGFCDQWHBMDEHB-PMHRFVFWSA-N 50031479 CHEMBL3358545 Melanocortin receptor 4 Mus musculus 0.051000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031479&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722937 103940110 CHEMBL3358545 ZINC34633736 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245342 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CCc2cn(CCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 InChI=1S/C51H69N17O8/c1-3-4-15-38(59-30(2)69)45(71)62-40-20-19-33-28-68(67-66-33)22-11-18-37(44(52)70)60-49(75)42(24-32-26-57-36-16-9-8-14-35(32)36)64-46(72)39(17-10-21-56-51(53)54)61-48(74)41(23-31-12-6-5-7-13-31)63-50(76)43(65-47(40)73)25-34-27-55-29-58-34/h5-9,12-14,16,26-29,37-43,57H,3-4,10-11,15,17-25H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,75)(H,61,74)(H,62,71)(H,63,76)(H,64,72)(H,65,73)(H4,53,54,56)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 KRBJCNKRJSCANK-PMHRFVFWSA-N 50031486 CHEMBL3358544 Melanocortin receptor 4 Mus musculus 0.220000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031486&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722936 103940117 CHEMBL3358544 ZINC26397787 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245343 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1Cc2cn(CCCC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](Cc3cnc[nH]3)NC1=O)C(N)=O)nn2 InChI=1S/C51H69N17O8/c1-3-4-16-38(59-30(2)69)45(71)64-43-25-34-28-68(67-66-34)21-11-10-18-37(44(52)70)60-48(74)41(23-32-26-57-36-17-9-8-15-35(32)36)63-46(72)39(19-12-20-56-51(53)54)61-47(73)40(22-31-13-6-5-7-14-31)62-49(75)42(65-50(43)76)24-33-27-55-29-58-33/h5-9,13-15,17,26-29,37-43,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,52,70)(H,55,58)(H,59,69)(H,60,74)(H,61,73)(H,62,75)(H,63,72)(H,64,71)(H,65,76)(H4,53,54,56)/t37-,38-,39-,40+,41-,42-,43-/m0/s1 KXPGBMNMTKVKHX-ZRBRQIMBSA-N 50031487 CHEMBL3358543 Melanocortin receptor 4 Mus musculus 1.6 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031487&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722935 103940118 CHEMBL3358543 ZINC26401378 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245344 CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCNC(C)=O)C(N)=O InChI=1S/C52H74N16O10/c1-29(2)21-39(62-31(4)70)47(74)68-43(25-44(53)71)51(78)67-42(24-34-27-57-28-61-34)50(77)65-40(22-32-13-6-5-7-14-32)48(75)64-38(18-12-20-59-52(55)56)46(73)66-41(23-33-26-60-36-16-9-8-15-35(33)36)49(76)63-37(45(54)72)17-10-11-19-58-30(3)69/h5-9,13-16,26-29,37-43,60H,10-12,17-25H2,1-4H3,(H2,53,71)(H2,54,72)(H,57,61)(H,58,69)(H,62,70)(H,63,76)(H,64,75)(H,65,77)(H,66,73)(H,67,78)(H,68,74)(H4,55,56,59)/t37-,38-,39-,40+,41-,42-,43-/m0/s1 VYNGHUMPDYNLGJ-ZRBRQIMBSA-N 50031499 CHEMBL3358542 Melanocortin receptor 4 Mus musculus 0.310000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031499&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722934 103940130 CHEMBL3358542 ZINC26404589 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245345 CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O InChI=1S/C50H71N15O10/c1-3-4-16-36(59-29(2)66)44(70)65-41(25-42(67)68)49(75)64-40(24-32-27-55-28-58-32)48(74)62-38(22-30-13-6-5-7-14-30)46(72)61-37(19-12-21-56-50(53)54)45(71)63-39(23-31-26-57-34-17-9-8-15-33(31)34)47(73)60-35(43(52)69)18-10-11-20-51/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25,51H2,1-2H3,(H2,52,69)(H,55,58)(H,59,66)(H,60,73)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,67,68)(H4,53,54,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1 VYTCDVWNUIRJEU-MFVUMRCOSA-N 50031500 CHEMBL2372859 Melanocortin receptor 4 Mus musculus 0.210000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031500&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9919669 103940131 CHEMBL2372859 C00615 ZINC26471062 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245346 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.200000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245347 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O InChI=1S/C50H71N17O8/c1-4-6-17-36(43(51)69)61-48(74)41(25-32-27-57-35-19-12-11-16-34(32)35)65-45(71)38(20-13-22-56-50(52)53)62-47(73)40(24-31-14-9-8-10-15-31)64-49(75)42(26-33-28-55-29-58-33)66-46(72)39(21-23-59-67-54)63-44(70)37(18-7-5-2)60-30(3)68/h8-12,14-16,19,27-29,36-42,57H,4-7,13,17-18,20-26H2,1-3H3,(H2,51,69)(H,55,58)(H,60,68)(H,61,74)(H,62,73)(H,63,70)(H,64,75)(H,65,71)(H,66,72)(H4,52,53,56)/t36-,37-,38-,39-,40+,41-,42-/m0/s1 NMYXFCWJVYVJBL-PCYFNTAWSA-N 50031488 CHEMBL3358541 Melanocortin receptor 4 Mus musculus 0.058000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031488&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722933 103940119 CHEMBL3358541 ZINC26475304 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245348 CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O InChI=1S/C50H71N17O8/c1-4-6-17-37(60-30(3)68)44(70)62-38(18-7-5-2)45(71)66-42(26-33-28-55-29-58-33)49(75)64-40(24-31-14-9-8-10-15-31)47(73)63-39(20-13-22-56-50(52)53)46(72)65-41(25-32-27-57-35-19-12-11-16-34(32)35)48(74)61-36(43(51)69)21-23-59-67-54/h8-12,14-16,19,27-29,36-42,57H,4-7,13,17-18,20-26H2,1-3H3,(H2,51,69)(H,55,58)(H,60,68)(H,61,74)(H,62,70)(H,63,73)(H,64,75)(H,65,72)(H,66,71)(H4,52,53,56)/t36-,37-,38-,39-,40+,41-,42-/m0/s1 FAONKRMCZFSASU-PCYFNTAWSA-N 50031489 CHEMBL3352878 Melanocortin receptor 4 Mus musculus 0.290000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031489&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722932 103940120 CHEMBL3352878 ZINC26403021 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245349 CCCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O InChI=1S/C51H73N17O8/c1-4-6-8-12-21-37(44(52)70)62-48(74)41(25-33-27-58-36-20-14-13-18-35(33)36)65-46(72)39(22-15-23-57-51(53)54)63-47(73)40(24-32-16-10-9-11-17-32)64-49(75)42(26-34-28-56-30-59-34)66-50(76)43(29-60-68-55)67-45(71)38(19-7-5-2)61-31(3)69/h9-11,13-14,16-18,20,27-28,30,37-43,58H,4-8,12,15,19,21-26,29H2,1-3H3,(H2,52,70)(H,56,59)(H,61,69)(H,62,74)(H,63,73)(H,64,75)(H,65,72)(H,66,76)(H,67,71)(H4,53,54,57)/t37-,38-,39-,40+,41-,42-,43-/m0/s1 NQOHSNNZYWQEMU-ZRBRQIMBSA-N 50031490 CHEMBL3358540 Melanocortin receptor 4 Mus musculus 0.140000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031490&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722931 103940121 CHEMBL3358540 ZINC13741878 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245350 CCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O InChI=1S/C51H73N17O8/c1-4-6-9-20-37(44(52)70)62-49(75)42(26-33-28-58-36-19-13-12-17-35(33)36)66-46(72)39(21-14-23-57-51(53)54)63-48(74)41(25-32-15-10-8-11-16-32)65-50(76)43(27-34-29-56-30-59-34)67-47(73)40(22-24-60-68-55)64-45(71)38(18-7-5-2)61-31(3)69/h8,10-13,15-17,19,28-30,37-43,58H,4-7,9,14,18,20-27H2,1-3H3,(H2,52,70)(H,56,59)(H,61,69)(H,62,75)(H,63,74)(H,64,71)(H,65,76)(H,66,72)(H,67,73)(H4,53,54,57)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 IEQKKCKIIGHHAM-PMHRFVFWSA-N 50031492 CHEMBL3358539 Melanocortin receptor 4 Mus musculus 0.098000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031492 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031492&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722930 103940123 CHEMBL3358539 ZINC26472968 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245351 CCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)[C@H](CCCC)NC(C)=O)C(N)=O InChI=1S/C51H73N17O8/c1-4-6-18-37(44(52)70)62-49(75)42(26-33-28-58-36-20-12-11-17-35(33)36)66-46(72)39(21-13-23-57-51(53)54)64-48(74)41(25-32-15-9-8-10-16-32)65-50(76)43(27-34-29-56-30-59-34)67-47(73)40(22-14-24-60-68-55)63-45(71)38(19-7-5-2)61-31(3)69/h8-12,15-17,20,28-30,37-43,58H,4-7,13-14,18-19,21-27H2,1-3H3,(H2,52,70)(H,56,59)(H,61,69)(H,62,75)(H,63,71)(H,64,74)(H,65,76)(H,66,72)(H,67,73)(H4,53,54,57)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 XSZXAQQQODZNFG-PMHRFVFWSA-N 50031493 CHEMBL3358538 Melanocortin receptor 4 Mus musculus 2.2 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031493 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031493&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722929 103940124 CHEMBL3358538 ZINC26470082 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245352 CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCCN=[N+]=[N-])C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC#C)C(N)=O InChI=1S/C51H69N17O8/c1-4-6-19-38(61-31(3)69)45(71)63-39(21-12-13-24-60-68-55)46(72)67-43(27-34-29-56-30-59-34)50(76)65-41(25-32-16-8-7-9-17-32)48(74)64-40(22-14-23-57-51(53)54)47(73)66-42(49(75)62-37(15-5-2)44(52)70)26-33-28-58-36-20-11-10-18-35(33)36/h2,7-11,16-18,20,28-30,37-43,58H,4,6,12-15,19,21-27H2,1,3H3,(H2,52,70)(H,56,59)(H,61,69)(H,62,75)(H,63,71)(H,64,74)(H,65,76)(H,66,73)(H,67,72)(H4,53,54,57)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 DIDFXWFVHNRNMN-PMHRFVFWSA-N 50031494 CHEMBL3358537 Melanocortin receptor 4 Mus musculus 0.810000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031494 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031494&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722928 103940125 CHEMBL3358537 ZINC26403870 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245353 CCCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CN=[N+]=[N-])C(N)=O InChI=1S/C51H73N17O8/c1-4-6-8-12-21-38(62-45(71)37(19-7-5-2)61-31(3)69)46(72)66-42(26-34-28-56-30-59-34)50(76)64-40(24-32-16-10-9-11-17-32)48(74)63-39(22-15-23-57-51(53)54)47(73)65-41(49(75)67-43(44(52)70)29-60-68-55)25-33-27-58-36-20-14-13-18-35(33)36/h9-11,13-14,16-18,20,27-28,30,37-43,58H,4-8,12,15,19,21-26,29H2,1-3H3,(H2,52,70)(H,56,59)(H,61,69)(H,62,71)(H,63,74)(H,64,76)(H,65,73)(H,66,72)(H,67,75)(H4,53,54,57)/t37-,38-,39-,40+,41-,42-,43-/m0/s1 GMRAYQVDTHJHDB-ZRBRQIMBSA-N 50031495 CHEMBL3358536 Melanocortin receptor 4 Mus musculus 0.190000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031495&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722927 103940126 CHEMBL3358536 ZINC26470089 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245354 CCCCC[C@H](NC(=O)[C@H](CCCC)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCN=[N+]=[N-])C(N)=O InChI=1S/C51H73N17O8/c1-4-6-9-20-39(63-45(71)38(18-7-5-2)61-31(3)69)46(72)67-43(27-34-29-56-30-59-34)50(76)65-41(25-32-15-10-8-11-16-32)48(74)64-40(21-14-23-57-51(53)54)47(73)66-42(26-33-28-58-36-19-13-12-17-35(33)36)49(75)62-37(44(52)70)22-24-60-68-55/h8,10-13,15-17,19,28-30,37-43,58H,4-7,9,14,18,20-27H2,1-3H3,(H2,52,70)(H,56,59)(H,61,69)(H,62,75)(H,63,71)(H,64,74)(H,65,76)(H,66,73)(H,67,72)(H4,53,54,57)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 XKDVAFONAIGHHA-PMHRFVFWSA-N 50031496 CHEMBL3358535 Melanocortin receptor 4 Mus musculus 0.130000 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031496&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722926 103940127 CHEMBL3358535 ZINC13741883 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245355 CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=[N+]=[N-])C(N)=O InChI=1S/C51H73N17O8/c1-4-6-18-38(61-31(3)69)45(71)63-39(19-7-5-2)46(72)67-43(27-34-29-56-30-59-34)50(76)65-41(25-32-15-9-8-10-16-32)48(74)64-40(22-13-23-57-51(53)54)47(73)66-42(26-33-28-58-36-20-12-11-17-35(33)36)49(75)62-37(44(52)70)21-14-24-60-68-55/h8-12,15-17,20,28-30,37-43,58H,4-7,13-14,18-19,21-27H2,1-3H3,(H2,52,70)(H,56,59)(H,61,69)(H,62,75)(H,63,71)(H,64,74)(H,65,76)(H,66,73)(H,67,72)(H4,53,54,57)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 ODNNSKWWOYPWAO-PMHRFVFWSA-N 50031497 CHEMBL3358534 Melanocortin receptor 4 Mus musculus 2.2 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031497&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722925 103940128 CHEMBL3358534 ZINC26468408 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50245356 CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC#C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN=[N+]=[N-])C(N)=O InChI=1S/C51H69N17O8/c1-4-6-19-39(61-31(3)69)46(72)63-38(15-5-2)45(71)67-43(27-34-29-56-30-59-34)50(76)65-41(25-32-16-8-7-9-17-32)48(74)64-40(22-14-23-57-51(53)54)47(73)66-42(26-33-28-58-36-20-11-10-18-35(33)36)49(75)62-37(44(52)70)21-12-13-24-60-68-55/h2,7-11,16-18,20,28-30,37-43,58H,4,6,12-15,19,21-27H2,1,3H3,(H2,52,70)(H,56,59)(H,61,69)(H,62,75)(H,63,72)(H,64,74)(H,65,76)(H,66,73)(H,67,71)(H4,53,54,57)/t37-,38-,39-,40-,41+,42-,43-/m0/s1 LWUHWHABBRUJHH-PMHRFVFWSA-N 50031498 CHEMBL3358533 Melanocortin receptor 4 Mus musculus 1.5 ChEMBL 10.1021/jm501027w 10.7270/Q21G0NVT 25347033 Testa, C; Scrima, M; Grimaldi, M; D'Ursi, AM; Dirain, ML; Lubin-Germain, N; Singh, A; Haskell-Luevano, C; Chorev, M; Rovero, P; Papini, AM University of Cergy-Pontoise http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031498&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118722924 103940129 CHEMBL3358533 ZINC26403331 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327872 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O 50027084 Melatonan Melanocortin receptor 4 Mus musculus 0.050000 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50027084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50027084&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 92432 277286650 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327873 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O 50080576 CHEMBL3422426 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080576&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9898183 313074187 CHEMBL3422426 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327874 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 5.4 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327875 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 50080583 CHEMBL3422427 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080583&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118735604 313074194 CHEMBL3422427 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327876 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O 50080582 CHEMBL3422428 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080582&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118735605 313074193 CHEMBL3422428 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327877 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O 50080581 CHEMBL3422429 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080581&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118735606 313074192 CHEMBL3422429 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327878 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O 50080578 CHEMBL3422432 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080578&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118735609 313074189 CHEMBL3422432 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327879 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O 50080577 CHEMBL3422433 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080577&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118735610 313074188 CHEMBL3422433 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327880 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O 50080578 CHEMBL3422432 Melanocortin receptor 4 Mus musculus <6.0 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080578&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118735609 313074189 CHEMBL3422432 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50327881 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O 50080577 CHEMBL3422433 Melanocortin receptor 4 Mus musculus <6.0 ChEMBL 10.1021/ml500340z 10.7270/Q2NC62W2 25699138 Doering, SR; Todorovic, A; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080577&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 118735610 313074188 CHEMBL3422433 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343092 C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O InChI=1S/C74H92N16O15/c1-42-62(94)82-52(22-13-33-78-74(76)77)65(97)84-55(37-46-18-9-5-10-19-46)69(101)85-56(38-47-20-11-6-12-21-47)70(102)86-57(41-61(75)93)68(100)81-43(2)63(95)83-53(36-45-16-7-4-8-17-45)66(98)80-44(3)64(96)88-58(40-49-27-31-51(92)32-28-49)72(104)90-35-15-24-60(90)73(105)89-34-14-23-59(89)71(103)87-54(67(99)79-42)39-48-25-29-50(91)30-26-48/h4-12,16-21,25-32,42-44,52-60,91-92H,13-15,22-24,33-41H2,1-3H3,(H2,75,93)(H,79,99)(H,80,98)(H,81,100)(H,82,94)(H,83,95)(H,84,97)(H,85,101)(H,86,102)(H,87,103)(H,88,96)(H4,76,77,78)/t42-,43-,44-,52-,53-,54-,55-,56-,57-,58-,59-,60+/m0/s1 XYIDQVLTFQUKGG-NKWBYMEMSA-N 50089424 CHEMBL3577979 Melanocortin receptor 4 Mus musculus 160 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089424 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089424&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178149 318472606 CHEMBL3577979 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343093 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H64N12O9/c1-30-42(64)60-38(28-33-18-9-4-10-19-33)48(70)62-25-13-22-40(62)49(71)61-24-12-21-39(61)47(69)56-34(20-11-23-54-50(52)53)43(65)57-35(26-31-14-5-2-6-15-31)45(67)58-36(27-32-16-7-3-8-17-32)46(68)59-37(29-41(51)63)44(66)55-30/h2-10,14-19,30,34-40H,11-13,20-29H2,1H3,(H2,51,63)(H,55,66)(H,56,69)(H,57,65)(H,58,67)(H,59,68)(H,60,64)(H4,52,53,54)/t30-,34-,35-,36-,37-,38-,39-,40+/m0/s1 MTKQTEXYJKPBQD-GNDHHEKASA-N 50089398 CHEMBL3577981 Melanocortin receptor 4 Mus musculus 20 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089398&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178151 103988187 CHEMBL3577981 ZINC26489473 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343094 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)-c2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C56H68N12O9/c1-34-48(70)66-44(32-36-16-7-3-8-17-36)54(76)68-29-13-22-46(68)55(77)67-28-12-21-45(67)53(75)62-40(20-11-27-60-56(58)59)49(71)63-42(31-37-23-25-39(26-24-37)38-18-9-4-10-19-38)51(73)64-41(30-35-14-5-2-6-15-35)52(74)65-43(33-47(57)69)50(72)61-34/h2-10,14-19,23-26,34,40-46H,11-13,20-22,27-33H2,1H3,(H2,57,69)(H,61,72)(H,62,75)(H,63,71)(H,64,73)(H,65,74)(H,66,70)(H4,58,59,60)/t34-,40-,41-,42-,43-,44-,45-,46+/m0/s1 VOZOJZLWKUURJE-DYRRNQNHSA-N 50089399 CHEMBL3577982 Melanocortin receptor 4 Mus musculus 160 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089399&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178152 103988188 CHEMBL3577982 ZINC36152156 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343095 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(CCc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C51H66N12O9/c1-31-43(65)61-39(29-34-18-9-4-10-19-34)49(71)63-27-13-22-41(63)50(72)62-26-12-21-40(62)48(70)58-35(20-11-25-55-51(53)54)44(66)57-36(24-23-32-14-5-2-6-15-32)45(67)59-37(28-33-16-7-3-8-17-33)47(69)60-38(30-42(52)64)46(68)56-31/h2-10,14-19,31,35-41H,11-13,20-30H2,1H3,(H2,52,64)(H,56,68)(H,57,66)(H,58,70)(H,59,67)(H,60,69)(H,61,65)(H4,53,54,55)/t31-,35-,36?,37-,38-,39-,40-,41+/m0/s1 ABDZRUUUDYEBLY-UZKRJQGBSA-N 50089402 CHEMBL3577985 Melanocortin receptor 4 Mus musculus 100 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089402&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178155 318472585 CHEMBL3577985 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343096 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C54H66N12O9/c1-32-46(68)64-42(29-34-16-6-3-7-17-34)52(74)66-27-13-24-44(66)53(75)65-26-12-23-43(65)51(73)60-38(22-11-25-58-54(56)57)47(69)62-40(30-36-20-10-19-35-18-8-9-21-37(35)36)50(72)61-39(28-33-14-4-2-5-15-33)49(71)63-41(31-45(55)67)48(70)59-32/h2-10,14-21,32,38-44H,11-13,22-31H2,1H3,(H2,55,67)(H,59,70)(H,60,73)(H,61,72)(H,62,69)(H,63,71)(H,64,68)(H4,56,57,58)/t32-,38-,39-,40?,41-,42-,43-,44+/m0/s1 CUCIWQUVTBPPBH-JHQNEBCVSA-N 50089404 CHEMBL3577986 Melanocortin receptor 4 Mus musculus 16 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089404&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178157 318472587 CHEMBL3577986 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343097 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)C(Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C54H66N12O9/c1-32-46(68)64-42(29-34-15-6-3-7-16-34)52(74)66-26-12-21-44(66)53(75)65-25-11-20-43(65)51(73)60-38(19-10-24-58-54(56)57)47(69)61-40(30-35-22-23-36-17-8-9-18-37(36)27-35)50(72)62-39(28-33-13-4-2-5-14-33)49(71)63-41(31-45(55)67)48(70)59-32/h2-9,13-18,22-23,27,32,38-44H,10-12,19-21,24-26,28-31H2,1H3,(H2,55,67)(H,59,70)(H,60,73)(H,61,69)(H,62,72)(H,63,71)(H,64,68)(H4,56,57,58)/t32-,38-,39-,40?,41-,42-,43-,44+/m0/s1 MCWLVPXLYJOXFN-JHQNEBCVSA-N 50089405 CHEMBL3577987 Melanocortin receptor 4 Mus musculus 100 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089405&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178158 318472588 CHEMBL3577987 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343098 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc(cc2)-c2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C56H68N12O9/c1-34-48(70)66-44(32-36-16-7-3-8-17-36)54(76)68-29-13-22-46(68)55(77)67-28-12-21-45(67)53(75)62-40(20-11-27-60-56(58)59)49(71)63-41(30-35-14-5-2-6-15-35)51(73)64-42(52(74)65-43(33-47(57)69)50(72)61-34)31-37-23-25-39(26-24-37)38-18-9-4-10-19-38/h2-10,14-19,23-26,34,40-46H,11-13,20-22,27-33H2,1H3,(H2,57,69)(H,61,72)(H,62,75)(H,63,71)(H,64,73)(H,65,74)(H,66,70)(H4,58,59,60)/t34-,40-,41-,42-,43-,44-,45-,46+/m0/s1 LSXYNCPPYBOAHI-DYRRNQNHSA-N 50089406 CHEMBL3577988 Melanocortin receptor 4 Mus musculus 160 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089406&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178159 318472589 CHEMBL3577988 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343099 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O)c1ccccc1 InChI=1S/C49H62N12O9/c1-29-41(63)58-36(27-31-16-7-3-8-17-31)47(69)61-25-13-22-38(61)48(70)60-24-12-21-37(60)45(67)55-33(20-11-23-53-49(51)52)42(64)56-34(26-30-14-5-2-6-15-30)44(66)59-40(32-18-9-4-10-19-32)46(68)57-35(28-39(50)62)43(65)54-29/h2-10,14-19,29,33-38,40H,11-13,20-28H2,1H3,(H2,50,62)(H,54,65)(H,55,67)(H,56,64)(H,57,68)(H,58,63)(H,59,66)(H4,51,52,53)/t29-,33-,34-,35-,36-,37-,38+,40?/m0/s1 XKBSPKDFMWAVMQ-JMUQTYQMSA-N 50089408 CHEMBL3577990 Melanocortin receptor 4 Mus musculus 1300 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089408&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178161 318472591 CHEMBL3577990 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343100 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C(CCc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C51H66N12O9/c1-31-43(65)61-39(29-34-18-9-4-10-19-34)49(71)63-27-13-22-41(63)50(72)62-26-12-21-40(62)48(70)58-35(20-11-25-55-51(53)54)44(66)59-37(28-33-16-7-3-8-17-33)47(69)57-36(24-23-32-14-5-2-6-15-32)45(67)60-38(30-42(52)64)46(68)56-31/h2-10,14-19,31,35-41H,11-13,20-30H2,1H3,(H2,52,64)(H,56,68)(H,57,69)(H,58,70)(H,59,66)(H,60,67)(H,61,65)(H4,53,54,55)/t31-,35-,36?,37-,38-,39-,40-,41+/m0/s1 BWTFBDOLYUCQEU-UZKRJQGBSA-N 50089409 CHEMBL3577991 Melanocortin receptor 4 Mus musculus 6.3 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089409&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178162 318472592 CHEMBL3577991 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343101 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C(Cc2cccc3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C54H66N12O9/c1-32-46(68)64-42(29-34-16-6-3-7-17-34)52(74)66-27-13-24-44(66)53(75)65-26-12-23-43(65)51(73)60-38(22-11-25-58-54(56)57)47(69)61-39(28-33-14-4-2-5-15-33)49(71)62-40(50(72)63-41(31-45(55)67)48(70)59-32)30-36-20-10-19-35-18-8-9-21-37(35)36/h2-10,14-21,32,38-44H,11-13,22-31H2,1H3,(H2,55,67)(H,59,70)(H,60,73)(H,61,69)(H,62,71)(H,63,72)(H,64,68)(H4,56,57,58)/t32-,38-,39-,40?,41-,42-,43-,44+/m0/s1 FNNIXVXBPJLPNQ-JHQNEBCVSA-N 50089411 CHEMBL3577993 Melanocortin receptor 4 Mus musculus 16 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089411&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178164 318472594 CHEMBL3577993 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343102 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)C(Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C54H66N12O9/c1-32-46(68)64-42(29-34-15-6-3-7-16-34)52(74)66-26-12-21-44(66)53(75)65-25-11-20-43(65)51(73)60-38(19-10-24-58-54(56)57)47(69)61-39(28-33-13-4-2-5-14-33)49(71)62-40(50(72)63-41(31-45(55)67)48(70)59-32)30-35-22-23-36-17-8-9-18-37(36)27-35/h2-9,13-18,22-23,27,32,38-44H,10-12,19-21,24-26,28-31H2,1H3,(H2,55,67)(H,59,70)(H,60,73)(H,61,69)(H,62,71)(H,63,72)(H,64,68)(H4,56,57,58)/t32-,38-,39-,40?,41-,42-,43-,44+/m0/s1 DNVIWLKKWIYAKK-JHQNEBCVSA-N 50089412 CHEMBL3577994 Melanocortin receptor 4 Mus musculus 63 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089412&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178165 318472595 CHEMBL3577994 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343103 C[C@@H]1NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C48H61N11O8/c1-30-41(61)57-37(28-33-18-9-4-10-19-33)46(66)59-25-13-22-39(59)47(67)58-24-12-21-38(58)45(65)54-34(20-11-23-51-48(49)50)43(63)56-36(27-32-16-7-3-8-17-32)44(64)55-35(26-31-14-5-2-6-15-31)42(62)52-29-40(60)53-30/h2-10,14-19,30,34-39H,11-13,20-29H2,1H3,(H,52,62)(H,53,60)(H,54,65)(H,55,64)(H,56,63)(H,57,61)(H4,49,50,51)/t30-,34-,35-,36-,37-,38-,39+/m0/s1 WMSRBVZRMJAEOB-VTXVSAOZSA-N 50089413 CHEMBL3577995 Melanocortin receptor 4 Mus musculus 4.0 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089413&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178166 318472596 CHEMBL3577995 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343104 C[C@@H]1NC(=O)C(CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O8/c1-30-41(62)58-37(28-33-18-9-4-10-19-33)47(68)61-25-13-22-40(61)48(69)60-24-12-21-39(60)46(67)55-34(20-11-23-53-49(51)52)42(63)56-35(26-31-14-5-2-6-15-31)43(64)57-36(27-32-16-7-3-8-17-32)44(65)59-38(29-50)45(66)54-30/h2-10,14-19,30,34-40H,11-13,20-29,50H2,1H3,(H,54,66)(H,55,67)(H,56,63)(H,57,64)(H,58,62)(H,59,65)(H4,51,52,53)/t30-,34-,35-,36-,37-,38?,39-,40+/m0/s1 IJUWOYISGCBYSL-KVDLRQQCSA-N 50089414 CHEMBL3577996 Melanocortin receptor 4 Mus musculus 0.790000 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089414&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178167 318472597 CHEMBL3577996 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343105 C[C@@H]1NC(=O)C(CCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H66N12O8/c1-31-42(63)60-39(30-34-18-9-4-10-19-34)48(69)62-27-13-22-41(62)49(70)61-26-12-21-40(61)47(68)57-35(20-11-25-54-50(52)53)44(65)58-38(29-33-16-7-3-8-17-33)46(67)59-37(28-32-14-5-2-6-15-32)45(66)56-36(23-24-51)43(64)55-31/h2-10,14-19,31,35-41H,11-13,20-30,51H2,1H3,(H,55,64)(H,56,66)(H,57,68)(H,58,65)(H,59,67)(H,60,63)(H4,52,53,54)/t31-,35-,36?,37-,38-,39-,40-,41+/m0/s1 IDMQXEOIBQUTEE-UZKRJQGBSA-N 50089415 CHEMBL3577997 Melanocortin receptor 4 Mus musculus 4.0 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089415&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178168 318472598 CHEMBL3577997 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343106 C[C@@H]1NC(=O)C(CCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C51H68N12O8/c1-32-43(64)61-40(31-35-19-9-4-10-20-35)49(70)63-28-14-24-42(63)50(71)62-27-13-23-41(62)48(69)58-37(22-12-26-55-51(53)54)45(66)59-39(30-34-17-7-3-8-18-34)47(68)60-38(29-33-15-5-2-6-16-33)46(67)57-36(21-11-25-52)44(65)56-32/h2-10,15-20,32,36-42H,11-14,21-31,52H2,1H3,(H,56,65)(H,57,67)(H,58,69)(H,59,66)(H,60,68)(H,61,64)(H4,53,54,55)/t32-,36?,37-,38-,39-,40-,41-,42+/m0/s1 DOFWVHHZMVXZDY-JMUIZCTFSA-N 50089416 CHEMBL3577998 Melanocortin receptor 4 Mus musculus 5.0 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089416 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089416&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178169 318472599 CHEMBL3577998 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343107 C[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C52H70N12O8/c1-33-44(65)62-41(32-36-20-9-4-10-21-36)50(71)64-29-15-25-43(64)51(72)63-28-14-24-42(63)49(70)59-38(23-13-27-56-52(54)55)46(67)60-40(31-35-18-7-3-8-19-35)48(69)61-39(30-34-16-5-2-6-17-34)47(68)58-37(45(66)57-33)22-11-12-26-53/h2-10,16-21,33,37-43H,11-15,22-32,53H2,1H3,(H,57,66)(H,58,68)(H,59,70)(H,60,67)(H,61,69)(H,62,65)(H4,54,55,56)/t33-,37-,38-,39-,40-,41-,42-,43+/m0/s1 GECURXWEFHHWFQ-LVXPXGLXSA-N 50089417 CHEMBL3577999 Melanocortin receptor 4 Mus musculus 5.0 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089417&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178170 318472600 CHEMBL3577999 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343108 C[C@@H]1NC(=O)[C@H](CCCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C53H72N14O8/c1-33-44(68)65-41(32-36-20-9-4-10-21-36)50(74)67-29-15-25-43(67)51(75)66-28-14-24-42(66)49(73)62-38(23-13-27-59-53(56)57)46(70)63-40(31-35-18-7-3-8-19-35)48(72)64-39(30-34-16-5-2-6-17-34)47(71)61-37(45(69)60-33)22-11-12-26-58-52(54)55/h2-10,16-21,33,37-43H,11-15,22-32H2,1H3,(H,60,69)(H,61,71)(H,62,73)(H,63,70)(H,64,72)(H,65,68)(H4,54,55,58)(H4,56,57,59)/t33-,37-,38-,39-,40-,41-,42-,43+/m0/s1 KEMPMTFFIIKEBA-LVXPXGLXSA-N 50089418 CHEMBL3578000 Melanocortin receptor 4 Mus musculus 4.0 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089418 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089418&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178171 318472601 CHEMBL3578000 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343000 C[C@@H](O)[C@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C82H110N22O19S2/c1-43(68(111)95-55(67(84)110)23-15-33-89-81(85)86)91-72(115)57(38-51-25-29-53(107)30-26-51)101-79(122)64-42-125-124-41-63(103-77(120)59(39-52-27-31-54(108)32-28-52)98-70(113)45(3)93-80(123)66(46(4)105)94-47(5)106)78(121)96-56(24-16-34-90-82(87)88)71(114)99-60(36-49-19-11-7-12-20-49)74(117)100-61(37-50-21-13-8-14-22-50)75(118)102-62(40-65(83)109)73(116)92-44(2)69(112)97-58(76(119)104-64)35-48-17-9-6-10-18-48/h6-14,17-22,25-32,43-46,55-64,66,105,107-108H,15-16,23-24,33-42H2,1-5H3,(H2,83,109)(H2,84,110)(H,91,115)(H,92,116)(H,93,123)(H,94,106)(H,95,111)(H,96,121)(H,97,112)(H,98,113)(H,99,114)(H,100,117)(H,101,122)(H,102,118)(H,103,120)(H,104,119)(H4,85,86,89)(H4,87,88,90)/t43-,44-,45-,46+,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,66-/m0/s1 HUXCMOSLMQJMGG-IJXJEDSYSA-N 50089420 CHEMBL3577976 Melanocortin receptor 4 Mus musculus 320 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089420 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089420&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178146 318472603 CHEMBL3577976 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343001 C[C@@H](O)[C@H](NC(C)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C84H114N22O21S2/c1-43-70(115)97-57(35-48-17-9-6-10-18-48)75(120)104-64(79(124)100-61(39-52-27-31-54(112)32-28-52)77(122)105-67(45(3)108)80(125)95-55(69(86)114)23-15-33-91-83(87)88)42-129-128-41-63(103-76(121)60(38-51-25-29-53(111)30-26-51)102-81(126)68(46(4)109)106-82(127)66(44(2)107)94-47(5)110)78(123)96-56(24-16-34-92-84(89)90)71(116)98-58(36-49-19-11-7-12-20-49)73(118)99-59(37-50-21-13-8-14-22-50)74(119)101-62(40-65(85)113)72(117)93-43/h6-14,17-22,25-32,43-46,55-64,66-68,107-109,111-112H,15-16,23-24,33-42H2,1-5H3,(H2,85,113)(H2,86,114)(H,93,117)(H,94,110)(H,95,125)(H,96,123)(H,97,115)(H,98,116)(H,99,118)(H,100,124)(H,101,119)(H,102,126)(H,103,121)(H,104,120)(H,105,122)(H,106,127)(H4,87,88,91)(H4,89,90,92)/t43-,44+,45+,46+,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,66-,67-,68-/m0/s1 CZAFJQFHVPEMKH-LXMWGWPASA-N 50089421 CHEMBL3577977 Melanocortin receptor 4 Mus musculus 160 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089421 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089421&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178147 318472604 CHEMBL3577977 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50343002 C[C@@H](O)[C@H](NC(C)=O)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CSSC[C@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C82H108N22O19S4/c1-43-68(111)95-55(33-46-15-7-4-8-16-46)73(116)103-63-41-126-125-40-62(77(120)94-54(22-14-32-90-82(87)88)69(112)96-56(34-47-17-9-5-10-18-47)71(114)97-57(35-48-19-11-6-12-20-48)72(115)100-60(38-65(83)109)70(113)91-43)102-75(118)59(37-50-25-29-52(108)30-26-50)99-79(122)64(104-80(123)66(44(2)105)92-45(3)106)42-127-124-39-61(76(119)93-53(67(84)110)21-13-31-89-81(85)86)101-74(117)58(98-78(63)121)36-49-23-27-51(107)28-24-49/h4-12,15-20,23-30,43-44,53-64,66,105,107-108H,13-14,21-22,31-42H2,1-3H3,(H2,83,109)(H2,84,110)(H,91,113)(H,92,106)(H,93,119)(H,94,120)(H,95,111)(H,96,112)(H,97,114)(H,98,121)(H,99,122)(H,100,115)(H,101,117)(H,102,118)(H,103,116)(H,104,123)(H4,85,86,89)(H4,87,88,90)/t43-,44+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63+,64-,66-/m0/s1 SJAAJSMNJLZUJU-KSROMGJUSA-N 50089422 CHEMBL3577978 Melanocortin receptor 4 Mus musculus 63 ChEMBL 10.1021/acs.jmedchem.5b00184 10.7270/Q2T155C9 25898270 Ericson, MD; Wilczynski, A; Sorensen, NB; Xiang, Z; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089422&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178148 318472605 CHEMBL3577978 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50349053 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 5.6 ChEMBL 10.1021/acsmedchemlett.5b00053 10.7270/Q2PZ5BJP 26005535 Singh, A; Tala, SR; Flores, V; Freeman, K; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50349054 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28-,29-/m0/s1 DFCJPPDAOZROBS-DZUOILHNSA-N 50034910 (S)-2-{(S)-2-[(S)-2-acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amideAc-His-DPhe-DArg-Trp-NH2::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide(Ac-His-Phe-Arg-Trp-NH2)::Ac-His-D-Phe-Arg-D-Trp-NH2::Ac-His-DPhe-Arg-Trp-NH2::Ac-His-Phe-Arg-Trp-NH2::CHEMBL50056 Melanocortin receptor 4 Mus musculus 1210 ChEMBL 10.1021/acsmedchemlett.5b00053 10.7270/Q2PZ5BJP 26005535 Singh, A; Tala, SR; Flores, V; Freeman, K; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034910&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10484741 103943035 CHEMBL50056 ZINC27638796 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50349055 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C28H36N8O4/c1-17(37)34-24(14-18-8-3-2-4-9-18)27(40)35-22(12-7-13-32-28(30)31)26(39)36-23(25(29)38)15-19-16-33-21-11-6-5-10-20(19)21/h2-6,8-11,16,22-24,33H,7,12-15H2,1H3,(H2,29,38)(H,34,37)(H,35,40)(H,36,39)(H4,30,31,32)/t22-,23-,24-/m0/s1 LUCUFURZWPZEOH-HJOGWXRNSA-N 50100754 Ac-Phe-Arg-Trp-NH2::CHEMBL441988 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.5b00053 10.7270/Q2PZ5BJP 26005535 Singh, A; Tala, SR; Flores, V; Freeman, K; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100754&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9828958 103997482 CHEMBL441988 ZINC26376986 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50349056 CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)Cc1ccccc1 50092136 CHEMBL3582443 Melanocortin receptor 4 Mus musculus 7678 ChEMBL 10.1021/acsmedchemlett.5b00053 10.7270/Q2PZ5BJP 26005535 Singh, A; Tala, SR; Flores, V; Freeman, K; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092136 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092136&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122179549 318473172 CHEMBL3582443 C00615 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50349057 CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O 50092134 CHEMBL3582445 Melanocortin receptor 4 Mus musculus 70 ChEMBL 10.1021/acsmedchemlett.5b00053 10.7270/Q2PZ5BJP 26005535 Singh, A; Tala, SR; Flores, V; Freeman, K; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092134&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122179551 318473170 CHEMBL3582445 C00615 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50349058 CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(N)=O)Cc1c[nH]c2ccccc12 InChI=1S/C34H44N4.2HI/c1-2-6-14-24-36-32-22-28-38(34-20-12-10-18-30(32)34)26-16-8-4-3-7-15-25-37-27-21-31(35-23-13-5-1)29-17-9-11-19-33(29)37;;/h9-12,17-22,27-28H,1-8,13-16,23-26H2;2*1H/b35-31+,36-32?;; MQUPWPHXBFNALI-JCJVBQLMSA-N 50092133 CHEMBL3582446 Melanocortin receptor 4 Mus musculus 12 ChEMBL 10.1021/acsmedchemlett.5b00053 10.7270/Q2PZ5BJP 26005535 Singh, A; Tala, SR; Flores, V; Freeman, K; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50092133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50092133&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122179552 103990336 CHEMBL3582446 C00615 ZINC13813218 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50349059 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 1.7 ChEMBL 10.1021/acsmedchemlett.5b00053 10.7270/Q2PZ5BJP 26005535 Singh, A; Tala, SR; Flores, V; Freeman, K; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50430750 CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C74H119N19O20/c1-15-38(9)58(91-65(105)48(83-43(14)95)25-27-54(97)98)72(112)82-41(12)63(103)85-49(26-28-55(99)100)66(106)90-57(37(7)8)71(111)87-50(31-35(3)4)67(107)81-40(11)62(102)84-47(23-19-29-78-74(76)77)64(104)86-51(32-44-33-79-46-22-18-17-21-45(44)46)68(108)92-60(42(13)94)70(110)80-34-53(96)88-59(39(10)16-2)73(113)93-30-20-24-52(93)69(109)89-56(36(5)6)61(75)101/h17-18,21-22,33,35-42,47-52,56-60,79,94H,15-16,19-20,23-32,34H2,1-14H3,(H2,75,101)(H,80,110)(H,81,107)(H,82,112)(H,83,95)(H,84,102)(H,85,103)(H,86,104)(H,87,111)(H,88,96)(H,89,109)(H,90,106)(H,91,105)(H,92,108)(H,97,98)(H,99,100)(H4,76,77,78)/t38-,39-,40-,41-,42+,47-,48-,49-,50-,51-,52-,56-,57-,58-,59-,60-/m0/s1 YPCGYAJVWZFDRM-FARYQAKQSA-N 50128359 CHEMBL3629476 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1016/j.bmcl.2015.09.046 10.7270/Q2V40X0X 26433448 Ericson, MD; Schnell, SM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128359&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122194336 104020124 CHEMBL3629476 ZINC13490050 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50430751 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 2.9 ChEMBL 10.1016/j.bmcl.2015.09.046 10.7270/Q2V40X0X 26433448 Ericson, MD; Schnell, SM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50430752 CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52?,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-DZZRGNEZSA-N 50128358 CHEMBL3629347 Melanocortin receptor 4 Mus musculus 0.340000 ChEMBL 10.1016/j.bmcl.2015.09.046 10.7270/Q2V40X0X 26433448 Ericson, MD; Schnell, SM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128358&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122194229 104020123 CHEMBL3629347 ZINC13490048 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492112 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 214 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492113 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O InChI=1S/C48H69N13O11/c1-32(62)58-41(26-35-28-52-31-57-35)47(68)60-39(24-33-10-3-2-4-11-33)46(67)59-38(14-7-15-55-48(50)51)45(66)61-40(25-34-27-56-37-13-6-5-12-36(34)37)44(65)54-17-9-19-70-21-23-71-22-20-69-18-8-16-53-43(64)30-72-29-42(49)63/h2-6,10-13,27-28,31,38-41,56H,7-9,14-26,29-30H2,1H3,(H2,49,63)(H,52,57)(H,53,64)(H,54,65)(H,58,62)(H,59,67)(H,60,68)(H,61,66)(H4,50,51,55)/t38-,39+,40-,41-/m0/s1 UBCQDVLHVQEUPW-XRFUAQTBSA-N 50164799 CHEMBL3797690 Melanocortin receptor 4 Mus musculus 83 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164799&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127046235 341097544 CHEMBL3797690 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492114 NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C46H67N13O10/c47-14-7-17-66-19-21-68-22-20-67-18-8-16-52-40(60)28-69-29-41(61)56-39(25-33-27-51-30-55-33)45(65)59-38(23-31-9-2-1-3-10-31)44(64)57-36(13-6-15-53-46(49)50)43(63)58-37(42(48)62)24-32-26-54-35-12-5-4-11-34(32)35/h1-5,9-12,26-27,30,36-39,54H,6-8,13-25,28-29,47H2,(H2,48,62)(H,51,55)(H,52,60)(H,56,61)(H,57,64)(H,58,63)(H,59,65)(H4,49,50,53)/t36-,37-,38+,39-/m0/s1 AQJDAJIMJIJQME-RUPCYPOASA-N 50164806 CHEMBL3799563 Melanocortin receptor 4 Mus musculus 292 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164806&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047913 341097551 CHEMBL3799563 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492115 CC(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(N)=O InChI=1S/C76H103N23O17/c1-44(100)90-52(34-47-36-80-43-89-47)68(109)92-51(32-45-14-3-2-4-15-45)67(108)91-50(18-7-25-81-76(78)79)66(107)93-53(33-46-35-82-49-17-6-5-16-48(46)49)75(116)99-31-13-24-59(99)74(115)88-42-65(106)98-30-12-23-58(98)73(114)87-41-64(105)97-29-11-22-57(97)72(113)86-40-63(104)96-28-10-21-56(96)71(112)85-39-62(103)95-27-9-20-55(95)70(111)84-38-61(102)94-26-8-19-54(94)69(110)83-37-60(77)101/h2-6,14-17,35-36,43,50-59,82H,7-13,18-34,37-42H2,1H3,(H2,77,101)(H,80,89)(H,83,110)(H,84,111)(H,85,112)(H,86,113)(H,87,114)(H,88,115)(H,90,100)(H,91,108)(H,92,109)(H,93,107)(H4,78,79,81)/t50-,51+,52-,53-,54-,55-,56-,57-,58-,59-/m0/s1 YTZSQMFKINJFMG-ZIJIQSQMSA-N 50164805 CHEMBL3798845 Melanocortin receptor 4 Mus musculus 841 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164805&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047209 341097550 CHEMBL3798845 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492116 NC(=N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C74H101N23O16/c75-64(104)50(32-44-34-81-47-16-5-4-15-46(44)47)91-66(106)49(18-7-25-80-74(76)77)90-67(107)51(31-43-13-2-1-3-14-43)92-68(108)52(33-45-35-78-42-88-45)89-58(98)36-82-69(109)53-19-8-26-93(53)60(100)38-84-71(111)55-21-10-28-95(55)62(102)40-86-73(113)57-23-12-30-97(57)63(103)41-87-72(112)56-22-11-29-96(56)61(101)39-85-70(110)54-20-9-27-94(54)59(99)37-83-65(105)48-17-6-24-79-48/h1-5,13-16,34-35,42,48-57,79,81H,6-12,17-33,36-41H2,(H2,75,104)(H,78,88)(H,82,109)(H,83,105)(H,84,111)(H,85,110)(H,86,113)(H,87,112)(H,89,98)(H,90,107)(H,91,106)(H,92,108)(H4,76,77,80)/t48-,49-,50-,51+,52-,53-,54-,55-,56-,57-/m0/s1 BBSFNUWKFPLIJR-JDRZNSOUSA-N 50164798 CHEMBL3799094 Melanocortin receptor 4 Mus musculus 258 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164798&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127046977 341097543 CHEMBL3799094 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492117 CC(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C108H141N33O21/c1-62(142)128-78(48-67-52-114-60-126-67)98(154)133-76(44-63-20-4-2-5-21-63)96(152)131-74(29-13-37-117-108(112)113)95(151)135-80(47-66-51-119-72-27-11-9-25-70(66)72)106(162)141-43-19-35-86(141)105(161)125-59-92(148)140-42-18-34-85(140)104(160)124-58-91(147)139-41-17-33-84(139)103(159)123-57-90(146)138-40-16-32-83(138)102(158)122-56-89(145)137-39-15-31-82(137)101(157)121-55-88(144)136-38-14-30-81(136)100(156)120-54-87(143)129-79(49-68-53-115-61-127-68)99(155)134-77(45-64-22-6-3-7-23-64)97(153)130-73(28-12-36-116-107(110)111)94(150)132-75(93(109)149)46-65-50-118-71-26-10-8-24-69(65)71/h2-11,20-27,50-53,60-61,73-86,118-119H,12-19,28-49,54-59H2,1H3,(H2,109,149)(H,114,126)(H,115,127)(H,120,156)(H,121,157)(H,122,158)(H,123,159)(H,124,160)(H,125,161)(H,128,142)(H,129,143)(H,130,153)(H,131,152)(H,132,150)(H,133,154)(H,134,155)(H,135,151)(H4,110,111,116)(H4,112,113,117)/t73-,74-,75-,76+,77+,78-,79?,80-,81-,82-,83-,84-,85-,86-/m0/s1 IMIABEFKOHFRBE-ASYFAHLQSA-N 50164797 CHEMBL3797808 Melanocortin receptor 4 Mus musculus 33 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164797&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127048118 341097542 CHEMBL3797808 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492118 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C80H107N23O15/c1-50(104)96-67(40-55-44-86-48-94-55)77(113)101-64(36-51-16-4-2-5-17-51)75(111)99-62(25-13-27-91-80(84)85)74(110)103-66(39-54-43-93-60-23-11-9-21-58(54)60)72(108)89-29-15-31-116-33-35-117-34-32-115-30-14-28-88-69(105)46-118-47-70(106)97-68(41-56-45-87-49-95-56)78(114)102-65(37-52-18-6-3-7-19-52)76(112)98-61(24-12-26-90-79(82)83)73(109)100-63(71(81)107)38-53-42-92-59-22-10-8-20-57(53)59/h2-11,16-23,42-45,48-49,61-68,92-93H,12-15,24-41,46-47H2,1H3,(H2,81,107)(H,86,94)(H,87,95)(H,88,105)(H,89,108)(H,96,104)(H,97,106)(H,98,112)(H,99,111)(H,100,109)(H,101,113)(H,102,114)(H,103,110)(H4,82,83,90)(H4,84,85,91)/t61-,62-,63-,64+,65+,66-,67-,68-/m0/s1 CDSFGYYJZFLWLX-HJJFOVLISA-N 50164804 CHEMBL3798421 Melanocortin receptor 4 Mus musculus 9.9 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164804&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047475 341097549 CHEMBL3798421 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492119 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C94H133N25O21/c1-62(120)112-79(50-67-54-100-60-110-67)91(131)117-76(46-63-18-4-2-5-19-63)89(129)115-74(27-13-29-107-94(98)99)88(128)119-78(49-66-53-109-72-25-11-9-23-70(66)72)86(126)105-33-17-37-136-41-45-138-44-40-134-35-15-31-103-82(122)57-139-56-81(121)102-30-14-34-133-38-42-137-43-39-135-36-16-32-104-83(123)58-140-59-84(124)113-80(51-68-55-101-61-111-68)92(132)118-77(47-64-20-6-3-7-21-64)90(130)114-73(26-12-28-106-93(96)97)87(127)116-75(85(95)125)48-65-52-108-71-24-10-8-22-69(65)71/h2-11,18-25,52-55,60-61,73-80,108-109H,12-17,26-51,56-59H2,1H3,(H2,95,125)(H,100,110)(H,101,111)(H,102,121)(H,103,122)(H,104,123)(H,105,126)(H,112,120)(H,113,124)(H,114,130)(H,115,129)(H,116,127)(H,117,131)(H,118,132)(H,119,128)(H4,96,97,106)(H4,98,99,107)/t73-,74-,75-,76+,77+,78-,79-,80-/m0/s1 KJUUQMJYKGOSKZ-VAMAGGONSA-N 50164803 CHEMBL3799955 Melanocortin receptor 4 Mus musculus 54 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164803&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047853 341097548 CHEMBL3799955 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492120 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C38H45N11O5/c1-22(50)46-33(18-27-20-42-21-45-27)37(54)49-32(16-23-12-13-24-7-2-3-8-25(24)15-23)36(53)47-30(11-6-14-43-38(40)41)35(52)48-31(34(39)51)17-26-19-44-29-10-5-4-9-28(26)29/h2-5,7-10,12-13,15,19-21,30-33,44H,6,11,14,16-18H2,1H3,(H2,39,51)(H,42,45)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,40,41,43)/t30-,31-,32+,33-/m0/s1 OHBCPCNJWIQQPW-SSNHPIBPSA-N 50115362 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-naphthalen-2-yl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL103817 Melanocortin receptor 4 Mus musculus 26 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115362&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11039918 104009339 CHEMBL103817 ZINC26834920 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492121 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O InChI=1S/C52H71N13O11/c1-34(66)62-45(28-39-30-56-33-61-39)51(72)64-43(26-35-14-15-36-9-2-3-10-37(36)25-35)50(71)63-42(13-6-16-59-52(54)55)49(70)65-44(27-38-29-60-41-12-5-4-11-40(38)41)48(69)58-18-8-20-74-22-24-75-23-21-73-19-7-17-57-47(68)32-76-31-46(53)67/h2-5,9-12,14-15,25,29-30,33,42-45,60H,6-8,13,16-24,26-28,31-32H2,1H3,(H2,53,67)(H,56,61)(H,57,68)(H,58,69)(H,62,66)(H,63,71)(H,64,72)(H,65,70)(H4,54,55,59)/t42-,43+,44-,45-/m0/s1 RXENDXVKKZXQPW-CSYVQODNSA-N 50164802 CHEMBL3799408 Melanocortin receptor 4 Mus musculus 11 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164802&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047624 341097547 CHEMBL3799408 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492122 NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C50H69N13O10/c51-15-6-18-70-20-22-72-23-21-71-19-7-17-56-44(64)30-73-31-45(65)60-43(27-37-29-55-32-59-37)49(69)63-42(25-33-13-14-34-8-1-2-9-35(34)24-33)48(68)61-40(12-5-16-57-50(53)54)47(67)62-41(46(52)66)26-36-28-58-39-11-4-3-10-38(36)39/h1-4,8-11,13-14,24,28-29,32,40-43,58H,5-7,12,15-23,25-27,30-31,51H2,(H2,52,66)(H,55,59)(H,56,64)(H,60,65)(H,61,68)(H,62,67)(H,63,69)(H4,53,54,57)/t40-,41-,42+,43-/m0/s1 CVDQYXOEEAGKLB-HPYHLGIWSA-N 50164801 CHEMBL3798912 Melanocortin receptor 4 Mus musculus 22 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164801&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127046262 341097546 CHEMBL3798912 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492123 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C88H111N23O15/c1-54(112)104-75(44-63-48-94-52-102-63)85(121)109-72(40-55-24-26-57-14-2-4-16-59(57)38-55)83(119)107-70(23-11-29-99-88(92)93)82(118)111-74(43-62-47-101-68-21-9-7-19-66(62)68)80(116)97-31-13-33-124-35-37-125-36-34-123-32-12-30-96-77(113)50-126-51-78(114)105-76(45-64-49-95-53-103-64)86(122)110-73(41-56-25-27-58-15-3-5-17-60(58)39-56)84(120)106-69(22-10-28-98-87(90)91)81(117)108-71(79(89)115)42-61-46-100-67-20-8-6-18-65(61)67/h2-9,14-21,24-27,38-39,46-49,52-53,69-76,100-101H,10-13,22-23,28-37,40-45,50-51H2,1H3,(H2,89,115)(H,94,102)(H,95,103)(H,96,113)(H,97,116)(H,104,112)(H,105,114)(H,106,120)(H,107,119)(H,108,117)(H,109,121)(H,110,122)(H,111,118)(H4,90,91,98)(H4,92,93,99)/t69-,70-,71-,72+,73+,74-,75-,76-/m0/s1 JCKLYCFJKXMTIR-YQCXOBAMSA-N 50164800 CHEMBL3798768 Melanocortin receptor 4 Mus musculus 10 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164800&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047336 341097545 CHEMBL3798768 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492124 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 1.1 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492151 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 14 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492152 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(N)=O InChI=1S/C48H69N13O11/c1-32(62)58-41(26-35-28-52-31-57-35)47(68)60-39(24-33-10-3-2-4-11-33)46(67)59-38(14-7-15-55-48(50)51)45(66)61-40(25-34-27-56-37-13-6-5-12-36(34)37)44(65)54-17-9-19-70-21-23-71-22-20-69-18-8-16-53-43(64)30-72-29-42(49)63/h2-6,10-13,27-28,31,38-41,56H,7-9,14-26,29-30H2,1H3,(H2,49,63)(H,52,57)(H,53,64)(H,54,65)(H,58,62)(H,59,67)(H,60,68)(H,61,66)(H4,50,51,55)/t38-,39+,40-,41-/m0/s1 UBCQDVLHVQEUPW-XRFUAQTBSA-N 50164799 CHEMBL3797690 Melanocortin receptor 4 Mus musculus 5.7 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164799&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127046235 341097544 CHEMBL3797690 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492153 NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C46H67N13O10/c47-14-7-17-66-19-21-68-22-20-67-18-8-16-52-40(60)28-69-29-41(61)56-39(25-33-27-51-30-55-33)45(65)59-38(23-31-9-2-1-3-10-31)44(64)57-36(13-6-15-53-46(49)50)43(63)58-37(42(48)62)24-32-26-54-35-12-5-4-11-34(32)35/h1-5,9-12,26-27,30,36-39,54H,6-8,13-25,28-29,47H2,(H2,48,62)(H,51,55)(H,52,60)(H,56,61)(H,57,64)(H,58,63)(H,59,65)(H4,49,50,53)/t36-,37-,38+,39-/m0/s1 AQJDAJIMJIJQME-RUPCYPOASA-N 50164806 CHEMBL3799563 Melanocortin receptor 4 Mus musculus 19 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164806&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047913 341097551 CHEMBL3799563 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492154 CC(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(N)=O InChI=1S/C76H103N23O17/c1-44(100)90-52(34-47-36-80-43-89-47)68(109)92-51(32-45-14-3-2-4-15-45)67(108)91-50(18-7-25-81-76(78)79)66(107)93-53(33-46-35-82-49-17-6-5-16-48(46)49)75(116)99-31-13-24-59(99)74(115)88-42-65(106)98-30-12-23-58(98)73(114)87-41-64(105)97-29-11-22-57(97)72(113)86-40-63(104)96-28-10-21-56(96)71(112)85-39-62(103)95-27-9-20-55(95)70(111)84-38-61(102)94-26-8-19-54(94)69(110)83-37-60(77)101/h2-6,14-17,35-36,43,50-59,82H,7-13,18-34,37-42H2,1H3,(H2,77,101)(H,80,89)(H,83,110)(H,84,111)(H,85,112)(H,86,113)(H,87,114)(H,88,115)(H,90,100)(H,91,108)(H,92,109)(H,93,107)(H4,78,79,81)/t50-,51+,52-,53-,54-,55-,56-,57-,58-,59-/m0/s1 YTZSQMFKINJFMG-ZIJIQSQMSA-N 50164805 CHEMBL3798845 Melanocortin receptor 4 Mus musculus 74 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164805&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047209 341097550 CHEMBL3798845 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492155 NC(=N)NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C74H101N23O16/c75-64(104)50(32-44-34-81-47-16-5-4-15-46(44)47)91-66(106)49(18-7-25-80-74(76)77)90-67(107)51(31-43-13-2-1-3-14-43)92-68(108)52(33-45-35-78-42-88-45)89-58(98)36-82-69(109)53-19-8-26-93(53)60(100)38-84-71(111)55-21-10-28-95(55)62(102)40-86-73(113)57-23-12-30-97(57)63(103)41-87-72(112)56-22-11-29-96(56)61(101)39-85-70(110)54-20-9-27-94(54)59(99)37-83-65(105)48-17-6-24-79-48/h1-5,13-16,34-35,42,48-57,79,81H,6-12,17-33,36-41H2,(H2,75,104)(H,78,88)(H,82,109)(H,83,105)(H,84,111)(H,85,110)(H,86,113)(H,87,112)(H,89,98)(H,90,107)(H,91,106)(H,92,108)(H4,76,77,80)/t48-,49-,50-,51+,52-,53-,54-,55-,56-,57-/m0/s1 BBSFNUWKFPLIJR-JDRZNSOUSA-N 50164798 CHEMBL3799094 Melanocortin receptor 4 Mus musculus 15 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164798&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127046977 341097543 CHEMBL3799094 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492156 CC(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)N1CCCC1C(=O)NCC(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C108H141N33O21/c1-62(142)128-78(48-67-52-114-60-126-67)98(154)133-76(44-63-20-4-2-5-21-63)96(152)131-74(29-13-37-117-108(112)113)95(151)135-80(47-66-51-119-72-27-11-9-25-70(66)72)106(162)141-43-19-35-86(141)105(161)125-59-92(148)140-42-18-34-85(140)104(160)124-58-91(147)139-41-17-33-84(139)103(159)123-57-90(146)138-40-16-32-83(138)102(158)122-56-89(145)137-39-15-31-82(137)101(157)121-55-88(144)136-38-14-30-81(136)100(156)120-54-87(143)129-79(49-68-53-115-61-127-68)99(155)134-77(45-64-22-6-3-7-23-64)97(153)130-73(28-12-36-116-107(110)111)94(150)132-75(93(109)149)46-65-50-118-71-26-10-8-24-69(65)71/h2-11,20-27,50-53,60-61,73-86,118-119H,12-19,28-49,54-59H2,1H3,(H2,109,149)(H,114,126)(H,115,127)(H,120,156)(H,121,157)(H,122,158)(H,123,159)(H,124,160)(H,125,161)(H,128,142)(H,129,143)(H,130,153)(H,131,152)(H,132,150)(H,133,154)(H,134,155)(H,135,151)(H4,110,111,116)(H4,112,113,117)/t73-,74-,75-,76+,77+,78-,79?,80-,81-,82-,83-,84-,85-,86-/m0/s1 IMIABEFKOHFRBE-ASYFAHLQSA-N 50164797 CHEMBL3797808 Melanocortin receptor 4 Mus musculus 9.2 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164797&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127048118 341097542 CHEMBL3797808 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492157 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C80H107N23O15/c1-50(104)96-67(40-55-44-86-48-94-55)77(113)101-64(36-51-16-4-2-5-17-51)75(111)99-62(25-13-27-91-80(84)85)74(110)103-66(39-54-43-93-60-23-11-9-21-58(54)60)72(108)89-29-15-31-116-33-35-117-34-32-115-30-14-28-88-69(105)46-118-47-70(106)97-68(41-56-45-87-49-95-56)78(114)102-65(37-52-18-6-3-7-19-52)76(112)98-61(24-12-26-90-79(82)83)73(109)100-63(71(81)107)38-53-42-92-59-22-10-8-20-57(53)59/h2-11,16-23,42-45,48-49,61-68,92-93H,12-15,24-41,46-47H2,1H3,(H2,81,107)(H,86,94)(H,87,95)(H,88,105)(H,89,108)(H,96,104)(H,97,106)(H,98,112)(H,99,111)(H,100,109)(H,101,113)(H,102,114)(H,103,110)(H4,82,83,90)(H4,84,85,91)/t61-,62-,63-,64+,65+,66-,67-,68-/m0/s1 CDSFGYYJZFLWLX-HJJFOVLISA-N 50164804 CHEMBL3798421 Melanocortin receptor 4 Mus musculus 3.6 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164804&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047475 341097549 CHEMBL3798421 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492158 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C94H133N25O21/c1-62(120)112-79(50-67-54-100-60-110-67)91(131)117-76(46-63-18-4-2-5-19-63)89(129)115-74(27-13-29-107-94(98)99)88(128)119-78(49-66-53-109-72-25-11-9-23-70(66)72)86(126)105-33-17-37-136-41-45-138-44-40-134-35-15-31-103-82(122)57-139-56-81(121)102-30-14-34-133-38-42-137-43-39-135-36-16-32-104-83(123)58-140-59-84(124)113-80(51-68-55-101-61-111-68)92(132)118-77(47-64-20-6-3-7-21-64)90(130)114-73(26-12-28-106-93(96)97)87(127)116-75(85(95)125)48-65-52-108-71-24-10-8-22-69(65)71/h2-11,18-25,52-55,60-61,73-80,108-109H,12-17,26-51,56-59H2,1H3,(H2,95,125)(H,100,110)(H,101,111)(H,102,121)(H,103,122)(H,104,123)(H,105,126)(H,112,120)(H,113,124)(H,114,130)(H,115,129)(H,116,127)(H,117,131)(H,118,132)(H,119,128)(H4,96,97,106)(H4,98,99,107)/t73-,74-,75-,76+,77+,78-,79-,80-/m0/s1 KJUUQMJYKGOSKZ-VAMAGGONSA-N 50164803 CHEMBL3799955 Melanocortin receptor 4 Mus musculus 7.3 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164803&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127047853 341097548 CHEMBL3799955 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492159 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.460000 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492160 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 4.0 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50492161 CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(O)=O InChI=1S/C74H99N21O16S/c1-41(2)62(95-63(102)49(75)30-44-22-24-47(96)25-23-44)72(111)90-53(26-29-112-3)64(103)84-38-59(97)87-57(34-46-37-80-40-86-46)70(109)92-55(32-43-16-8-5-9-17-43)68(107)88-52(21-13-28-82-74(78)79)67(106)93-56(33-45-36-83-50-19-11-10-18-48(45)50)69(108)94-58(35-60(98)99)71(110)89-51(20-12-27-81-73(76)77)66(105)91-54(65(104)85-39-61(100)101)31-42-14-6-4-7-15-42/h4-11,14-19,22-25,36-37,40-41,49,51-58,62,83,96H,12-13,20-21,26-35,38-39,75H2,1-3H3,(H,80,86)(H,84,103)(H,85,104)(H,87,97)(H,88,107)(H,89,110)(H,90,111)(H,91,105)(H,92,109)(H,93,106)(H,94,108)(H,95,102)(H,98,99)(H,100,101)(H4,76,77,81)(H4,78,79,82)/t49-,51-,52-,53-,54-,55-,56+,57-,58-,62-/m0/s1 GZWUQPQBOGLSIM-MDMVXOTPSA-N 50026884 CHEMBL405282 Melanocortin receptor 4 Mus musculus 869 ChEMBL 10.1021/acs.jmedchem.5b01894 10.7270/Q2R2139S 26959173 Lensing, CJ; Freeman, KT; Schnell, SM; Adank, DN; Speth, RC; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026884&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44387680 103936468 CHEMBL405282 C00615 ZINC05140790 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50649908 CC(=O)NC(C)(C)[C@@H]1CC2(CCN(CC2)C(=O)[C@@H]2CN(C[C@H]2c2ccc(F)cc2F)C(C)(C)C)c2cc(Cl)c(C)cc12 InChI=1S/C34H44ClF2N3O2/c1-20-14-24-27(16-29(20)35)34(17-28(24)33(6,7)38-21(2)41)10-12-39(13-11-34)31(42)26-19-40(32(3,4)5)18-25(26)23-9-8-22(36)15-30(23)37/h8-9,14-16,25-26,28H,10-13,17-19H2,1-7H3,(H,38,41)/t25-,26+,28+/m0/s1 KMNARKQYUZICHM-ZRRKCSAHSA-N 50314764 CHEMBL1093304::trans-N-(2-((R)-1'-((3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-carbonyl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-3-yl)propan-2-yl)acetamide Melanocortin receptor 4 Mus musculus 22 ChEMBL 10.1016/j.bmcl.2010.06.062 10.7270/Q23F4Q07 20598882 He, S; Ye, Z; Dobbelaar, PH; Sebhat, IK; Guo, L; Liu, J; Jian, T; Lai, Y; Franklin, CL; Bakshi, RK; Dellureficio, JP; Hong, Q; Weinberg, DH; Macneil, T; Tang, R; Strack, AM; Tamvakopoulos, C; Peng, Q; Miller, RR; Stearns, RA; Chen, HY; Chen, AS; Fong, TM; Wyvratt, MJ; Nargund, RP Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50314764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50314764&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11753695 104149125 CHEMBL1093304 ZINC49781164 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739494 Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2ccccc2Cn2cnnc2)cc1 InChI=1S/C32H34ClN7O2/c33-27-11-9-23(10-12-27)17-29(37-31(41)28-18-24-5-1-2-6-25(24)19-34-28)32(42)40-15-13-39(14-16-40)30-8-4-3-7-26(30)20-38-21-35-36-22-38/h1-12,21-22,28-29,34H,13-20H2,(H,37,41)/t28-,29-/m1/s1 SQUPSEKHAYZJTP-FQLXRVMXSA-N 50134488 (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-[1,2,4]triazol-4-ylmethyl-phenyl)-piperazin-1-yl]-ethyl}-amide::CHEMBL333283 Melanocortin receptor 4 Mus musculus 38 ChEMBL 10.1016/s0960-894x(03)00796-0 10.7270/Q2P26ZNW 14552781 Dyck, B; Parker, J; Phillips, T; Carter, L; Murphy, B; Summers, R; Hermann, J; Baker, T; Cismowski, M; Saunders, J; Goodfellow, V Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134488&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44349019 104025042 CHEMBL333283 ZINC27216632 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739498 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 8.80 ChEMBL 10.1016/s0960-894x(03)00796-0 10.7270/Q2P26ZNW 14552781 Dyck, B; Parker, J; Phillips, T; Carter, L; Murphy, B; Summers, R; Hermann, J; Baker, T; Cismowski, M; Saunders, J; Goodfellow, V Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739522 Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1 InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1 HLCHESOMJVGDSJ-LOYHVIPDSA-N 50119368 (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::(R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-[4-cyclohexyl-4-(3H-[1,2,4]triazol-1-ylmethyl)-piperidin-1-yl]-2-oxo-ethyl}-amide::(R)-N-((R)-1-(4-((1H-1,2,4-triazol-1-yl)methyl)-4-cyclohexylpiperidin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [(R)-1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::CHEMBL339053::THIQ Melanocortin receptor 4 Mus musculus 7.6 ChEMBL 10.1016/s0960-894x(03)00796-0 10.7270/Q2P26ZNW 14552781 Dyck, B; Parker, J; Phillips, T; Carter, L; Murphy, B; Summers, R; Hermann, J; Baker, T; Cismowski, M; Saunders, J; Goodfellow, V Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50119368 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50119368&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1I8 7F58 9938402 104012586 CHEMBL339053 ZINC36269777 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739531 Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCN(CC2)c2ccccc2Cn2cncn2)cc1 InChI=1S/C32H34ClN7O2/c33-27-11-9-23(10-12-27)17-29(37-31(41)28-18-24-5-1-2-6-25(24)19-35-28)32(42)39-15-13-38(14-16-39)30-8-4-3-7-26(30)20-40-22-34-21-36-40/h1-12,21-22,28-29,35H,13-20H2,(H,37,41)/t28-,29-/m1/s1 PKHOEKKVDQTOOR-FQLXRVMXSA-N 50134486 (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-[1,2,4]triazol-1-ylmethyl-phenyl)-piperazin-1-yl]-ethyl}-amide::(R)-N-((R)-1-(4-(2-((1H-1,2,4-triazol-1-yl)methyl)phenyl)piperazin-1-yl)-3-(4-chlorophenyl)-1-oxopropan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide::1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-[1,2,4]triazol-1-ylmethyl-phenyl)-piperazin-1-yl]-ethyl}-amide::CHEMBL340355 Melanocortin receptor 4 Mus musculus 59 ChEMBL 10.1016/s0960-894x(03)00796-0 10.7270/Q2P26ZNW 14552781 Dyck, B; Parker, J; Phillips, T; Carter, L; Murphy, B; Summers, R; Hermann, J; Baker, T; Cismowski, M; Saunders, J; Goodfellow, V Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50134486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50134486&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 24848995 104025040 CHEMBL340355 ZINC27215901 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739872 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(CCCNC(N)=N)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-21(46)42-28(16-24-18-38-20-41-24)32(49)44-29(14-22-8-3-2-4-9-22)33(50)45(13-7-12-39-34(36)37)19-30(47)43-27(31(35)48)15-23-17-40-26-11-6-5-10-25(23)26/h2-6,8-11,17-18,20,27-29,40H,7,12-16,19H2,1H3,(H2,35,48)(H,38,41)(H,42,46)(H,43,47)(H,44,49)(H4,36,37,39)/t27-,28-,29-/m0/s1 OJCGTUCBGQEMMX-AWCRTANDSA-N 50136742 (S)-2-{2-[{(S)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionyl}-(3-guanidino-propyl)-amino]-acetylamino}-3-(1H-indol-3-yl)-propionamide::CHEMBL343094 Melanocortin receptor 4 Mus musculus 1100 ChEMBL 10.1016/j.bmcl.2003.08.078 10.7270/Q2N29XHH 14643357 Holder, JR; Bauzo, RM; Xiang, Z; Scott, J; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50136742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50136742&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44359590 104026954 CHEMBL343094 ZINC27522728 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739873 CC(=O)N(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)Cc1ccccc1 InChI=1S/C37H45N9O5/c1-24(47)46(22-26-13-6-3-7-14-26)23-33(48)43-32(19-25-11-4-2-5-12-25)36(51)44-30(17-10-18-41-37(39)40)35(50)45-31(34(38)49)20-27-21-42-29-16-9-8-15-28(27)29/h2-9,11-16,21,30-32,42H,10,17-20,22-23H2,1H3,(H2,38,49)(H,43,48)(H,44,51)(H,45,50)(H4,39,40,41)/t30-,31-,32-/m0/s1 CSOVRHGSAPSVOO-CPCREDONSA-N 50136743 (S)-2-{(S)-2-[2-(Acetyl-benzyl-amino)-acetylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL138771 Melanocortin receptor 4 Mus musculus 260 ChEMBL 10.1016/j.bmcl.2003.08.078 10.7270/Q2N29XHH 14643357 Holder, JR; Bauzo, RM; Xiang, Z; Scott, J; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50136743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50136743&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44359291 104026955 CHEMBL138771 ZINC27517508 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739876 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 5.4 ChEMBL 10.1016/j.bmcl.2003.08.078 10.7270/Q2N29XHH 14643357 Holder, JR; Bauzo, RM; Xiang, Z; Scott, J; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739888 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 17 ChEMBL 10.1016/j.bmcl.2003.08.078 10.7270/Q2N29XHH 14643357 Holder, JR; Bauzo, RM; Xiang, Z; Scott, J; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739891 CC(=O)N(CCc1cnc[nH]1)CC(=O)N(CC(=O)N(CCCCN)CC(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O)Cc1ccccc1 InChI=1S/C36H47N9O5/c1-27(46)42(18-14-30-20-39-26-41-30)23-36(50)45(21-28-9-3-2-4-10-28)25-35(49)43(16-8-7-15-37)24-34(48)44(22-33(38)47)17-13-29-19-40-32-12-6-5-11-31(29)32/h2-6,9-12,19-20,26,40H,7-8,13-18,21-25,37H2,1H3,(H2,38,47)(H,39,41) YYBOUVZNKIGKBH-UHFFFAOYSA-N 50136749 2-{{2-[{2-[(2-{Acetyl-[2-(1H-imidazol-4-yl)-ethyl]-amino}-acetyl)-benzyl-amino]-acetyl}-(4-amino-butyl)-amino]-acetyl}-[2-(1H-indol-3-yl)-ethyl]-amino}-acetamide::CHEMBL140324 Melanocortin receptor 4 Mus musculus 27200 ChEMBL 10.1016/j.bmcl.2003.08.078 10.7270/Q2N29XHH 14643357 Holder, JR; Bauzo, RM; Xiang, Z; Scott, J; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50136749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50136749&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44359589 104026961 CHEMBL140324 ZINC27522725 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739895 CC(=O)N(CCc1cnc[nH]1)CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H45N11O5/c1-22(47)46(15-13-25-19-39-21-42-25)20-31(48)43-30(16-23-8-3-2-4-9-23)34(51)44-28(12-7-14-40-35(37)38)33(50)45-29(32(36)49)17-24-18-41-27-11-6-5-10-26(24)27/h2-6,8-11,18-19,21,28-30,41H,7,12-17,20H2,1H3,(H2,36,49)(H,39,42)(H,43,48)(H,44,51)(H,45,50)(H4,37,38,40)/t28-,29-,30-/m0/s1 LQSYLOZZPPJYIZ-DTXPUJKBSA-N 50136746 (S)-2-[(S)-2-(2-{Acetyl-[2-(1H-imidazol-4-yl)-ethyl]-amino}-acetylamino)-3-phenyl-propionylamino]-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL140847 Melanocortin receptor 4 Mus musculus 880 ChEMBL 10.1016/j.bmcl.2003.08.078 10.7270/Q2N29XHH 14643357 Holder, JR; Bauzo, RM; Xiang, Z; Scott, J; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50136746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50136746&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44359591 104026958 CHEMBL140847 ZINC27522922 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50739900 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N(CCc1c[nH]c2ccccc12)CC(N)=O InChI=1S/C35H45N11O5/c1-22(47)43-30(17-25-19-39-21-42-25)33(50)45-29(16-23-8-3-2-4-9-23)32(49)44-28(12-7-14-40-35(37)38)34(51)46(20-31(36)48)15-13-24-18-41-27-11-6-5-10-26(24)27/h2-6,8-11,18-19,21,28-30,41H,7,12-17,20H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,49)(H,45,50)(H4,37,38,40)/t28-,29-,30-/m0/s1 DNTXCPMOMVOUSI-DTXPUJKBSA-N 50136748 (S)-2-{(S)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid carbamoylmethyl-[2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL138212 Melanocortin receptor 4 Mus musculus 640 ChEMBL 10.1016/j.bmcl.2003.08.078 10.7270/Q2N29XHH 14643357 Holder, JR; Bauzo, RM; Xiang, Z; Scott, J; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50136748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50136748&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44359731 104026960 CHEMBL138212 ZINC27518830 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738202 NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCC(Cc2ccccc2)CC1 InChI=1S/C28H38N6O2/c29-14-6-7-15-30-27(35)26(19-23-20-31-25-11-5-4-10-24(23)25)32-28(36)33-34-16-12-22(13-17-34)18-21-8-2-1-3-9-21/h1-5,8-11,20,22,26,31H,6-7,12-19,29H2,(H,30,35)(H2,32,33,36)/t26-/m0/s1 VUYFAMFIIFAPOD-SANMLTNESA-N 50129185 CHEMBL63850::N-(4-Amino-butyl)-2-[3-(4-benzyl-piperidin-1-yl)-ureido]-3-(1H-indol-3-yl)-propionamide Melanocortin receptor 4 Mus musculus 100000 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129185&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305763 104020827 CHEMBL63850 ZINC26181618 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738212 NCCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1 InChI=1S/C25H33N5O2/c26-14-8-1-2-9-15-27-24(31)23(16-20-18-28-22-13-7-6-12-21(20)22)30-25(32)29-17-19-10-4-3-5-11-19/h3-7,10-13,18,23,28H,1-2,8-9,14-17,26H2,(H,27,31)(H2,29,30,32)/t23-/m0/s1 UGXCXESQVHWUAG-QHCPKHFHSA-N 50129187 CHEMBL303283::N-(6-Amino-hexyl)-2-((S)-3-benzyl-ureido)-3-(1H-indol-3-yl)-propionamide Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129187&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305806 104020829 CHEMBL303283 ZINC13490466 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738213 CC1CCN(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)CC1 InChI=1S/C26H33N5O2/c1-19-11-13-31(14-12-19)18-29-25(32)24(15-21-17-27-23-10-6-5-9-22(21)23)30-26(33)28-16-20-7-3-2-4-8-20/h2-10,17,19,24,27H,11-16,18H2,1H3,(H,29,32)(H2,28,30,33)/t24-/m0/s1 MYTYZMBNMDOGRW-DEOSSOPVSA-N 50129182 2-(3-Benzyl-ureido)-3-(1H-indol-3-yl)-N-(4-methyl-piperidin-1-ylmethyl)-propionamide::CHEMBL64967 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129182&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305784 104020824 CHEMBL64967 ZINC26175348 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738221 NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NC1CCN(Cc2ccccc2)CC1 InChI=1S/C28H38N6O2/c29-14-6-7-15-30-27(35)26(18-22-19-31-25-11-5-4-10-24(22)25)33-28(36)32-23-12-16-34(17-13-23)20-21-8-2-1-3-9-21/h1-5,8-11,19,23,26,31H,6-7,12-18,20,29H2,(H,30,35)(H2,32,33,36)/t26-/m0/s1 OXMXHGSZCHXXHV-SANMLTNESA-N 50129181 CHEMBL305132::N-(4-Amino-butyl)-2-[3-(1-benzyl-piperidin-4-yl)-ureido]-3-(1H-indol-3-yl)-propionamide Melanocortin receptor 4 Mus musculus 2800 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305956 104020823 CHEMBL305132 ZINC26182829 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738224 NCCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1 InChI=1S/C24H31N5O2/c25-13-7-2-8-14-26-23(30)22(15-19-17-27-21-12-6-5-11-20(19)21)29-24(31)28-16-18-9-3-1-4-10-18/h1,3-6,9-12,17,22,27H,2,7-8,13-16,25H2,(H,26,30)(H2,28,29,31)/t22-/m0/s1 CWJHVSDNADCVQK-QFIPXVFZSA-N 50129186 CHEMBL305391::N-(5-Amino-pentyl)-2-((S)-3-benzyl-ureido)-3-(1H-indol-3-yl)-propionamide Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129186&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305712 104020828 CHEMBL305391 ZINC13490465 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738225 NCCCCNC(=O)[C@H](CCc1ccccc1)NC(=O)NCc1ccccc1 InChI=1S/C22H30N4O2/c23-15-7-8-16-24-21(27)20(14-13-18-9-3-1-4-10-18)26-22(28)25-17-19-11-5-2-6-12-19/h1-6,9-12,20H,7-8,13-17,23H2,(H,24,27)(H2,25,26,28)/t20-/m0/s1 ZYEKZRBOJZGNEJ-FQEVSTJZSA-N 50129178 (S)-N-(4-Amino-butyl)-2-(3-benzyl-ureido)-4-phenyl-butyramide::CHEMBL291870 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129178&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305844 104020820 CHEMBL291870 ZINC13490474 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738228 NCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1 InChI=1S/C22H27N5O2/c23-11-6-12-24-21(28)20(13-17-15-25-19-10-5-4-9-18(17)19)27-22(29)26-14-16-7-2-1-3-8-16/h1-5,7-10,15,20,25H,6,11-14,23H2,(H,24,28)(H2,26,27,29)/t20-/m0/s1 LTPXHKJHVKQPSW-FQEVSTJZSA-N 50129184 CHEMBL293673::N-(3-Amino-propyl)-2-((S)-3-benzyl-ureido)-3-(1H-indol-3-yl)-propionamide Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129184&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305805 104020826 CHEMBL293673 ZINC13490464 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738235 NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCCc1ccccc1 InChI=1S/C24H31N5O2/c25-13-6-7-14-26-23(30)22(16-19-17-28-21-11-5-4-10-20(19)21)29-24(31)27-15-12-18-8-2-1-3-9-18/h1-5,8-11,17,22,28H,6-7,12-16,25H2,(H,26,30)(H2,27,29,31)/t22-/m0/s1 ALCIJSWNWVGYMD-QFIPXVFZSA-N 50129192 CHEMBL431523::N-(4-Amino-butyl)-3-(1H-indol-3-yl)-2-(3-phenethyl-ureido)-propionamide Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129192&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305753 104020834 CHEMBL431523 ZINC13490470 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738237 Cc1cccc(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)c1 InChI=1S/C27H28N4O2/c1-19-8-7-11-21(14-19)17-29-26(32)25(15-22-18-28-24-13-6-5-12-23(22)24)31-27(33)30-16-20-9-3-2-4-10-20/h2-14,18,25,28H,15-17H2,1H3,(H,29,32)(H2,30,31,33)/t25-/m0/s1 IBFSTESMBHZKAL-VWLOTQADSA-N 50129183 2-(3-Benzyl-ureido)-3-(1H-indol-3-yl)-N-(3-methyl-benzyl)-propionamide::CHEMBL61681 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129183&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305815 104020825 CHEMBL61681 ZINC26171482 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738242 NCCCCNC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)NCc1ccccc1 InChI=1S/C28H34N4O3/c29-17-7-8-18-30-27(33)26(32-28(34)31-20-23-9-3-1-4-10-23)19-22-13-15-25(16-14-22)35-21-24-11-5-2-6-12-24/h1-6,9-16,26H,7-8,17-21,29H2,(H,30,33)(H2,31,32,34)/t26-/m0/s1 LJBHFCJUGLSHFE-SANMLTNESA-N 50129188 (S)-N-(4-Amino-butyl)-3-(4-benzyloxy-phenyl)-2-(3-benzyl-ureido)-propionamide::CHEMBL63867 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129188 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129188&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305885 104020830 CHEMBL63867 ZINC26183154 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738245 NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1 InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m0/s1 CKUHVWJCONRCIC-NRFANRHFSA-N 50129191 CHEMBL305559::N-(4-Amino-butyl)-2-(3-benzyl-ureido)-3-(1H-indol-3-yl)-propionamide Melanocortin receptor 4 Mus musculus 23700 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129191&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305790 104020833 CHEMBL305559 ZINC13490463 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738248 NCCCCNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NN1CCc2ccccc2C1 InChI=1S/C25H32N6O2/c26-12-5-6-13-27-24(32)23(15-20-16-28-22-10-4-3-9-21(20)22)29-25(33)30-31-14-11-18-7-1-2-8-19(18)17-31/h1-4,7-10,16,23,28H,5-6,11-15,17,26H2,(H,27,32)(H2,29,30,33)/t23-/m0/s1 BLQZIVNHYRDWGF-QHCPKHFHSA-N 50129180 CHEMBL62228::N-(4-Amino-butyl)-2-[3-(3,4-dihydro-1H-isoquinolin-2-yl)-ureido]-3-(1H-indol-3-yl)-propionamide Melanocortin receptor 4 Mus musculus 3400 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129180&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305770 104020822 CHEMBL62228 ZINC26171815 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738251 NCCCCNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)NCc1ccccc1 InChI=1S/C23H29N5O2/c24-12-6-7-13-25-22(29)21(14-18-16-26-20-11-5-4-10-19(18)20)28-23(30)27-15-17-8-2-1-3-9-17/h1-5,8-11,16,21,26H,6-7,12-15,24H2,(H,25,29)(H2,27,28,30)/t21-/m1/s1 CKUHVWJCONRCIC-OAQYLSRUSA-N 50129189 CHEMBL64954::N-(4-Amino-butyl)-2-(3-benzyl-ureido)-3-(1H-indol-3-yl)-propionamide Melanocortin receptor 4 Mus musculus 23700 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129189&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44305704 104020831 CHEMBL64954 ZINC13490476 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50738253 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 2470 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801607 CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C28H36N8O4/c1-17(37)34-24(14-18-8-3-2-4-9-18)27(40)35-22(12-7-13-32-28(30)31)26(39)36-23(25(29)38)15-19-16-33-21-11-6-5-10-20(19)21/h2-6,8-11,16,22-24,33H,7,12-15H2,1H3,(H2,29,38)(H,34,37)(H,35,40)(H,36,39)(H4,30,31,32)/t22-,23+,24+/m0/s1 LUCUFURZWPZEOH-RBZQAINGSA-N 50058961 (S)-2-((R)-2-Acetylamino-3-phenyl-propionylamino)-5-guanidino-pentanoic acid [(R)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-DPhe-Arg-DTrp-NH2::CHEMBL65339 Melanocortin receptor 4 Mus musculus 11200 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50058961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50058961&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9893728 103954863 CHEMBL65339 ZINC26182401 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801610 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 3.07 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801611 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 10.2 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801613 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C28H36N8O4/c1-17(37)34-24(14-18-8-3-2-4-9-18)27(40)35-22(12-7-13-32-28(30)31)26(39)36-23(25(29)38)15-19-16-33-21-11-6-5-10-20(19)21/h2-6,8-11,16,22-24,33H,7,12-15H2,1H3,(H2,29,38)(H,34,37)(H,35,40)(H,36,39)(H4,30,31,32)/t22-,23-,24-/m0/s1 LUCUFURZWPZEOH-HJOGWXRNSA-N 50100754 Ac-Phe-Arg-Trp-NH2::CHEMBL441988 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100754&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9828958 103997482 CHEMBL441988 ZINC26376986 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801621 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.32 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801626 CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C45H61N13O9/c1-3-4-14-32(53-26(2)59)40(63)55-34(17-18-38(60)61)42(65)58-37(22-29-24-49-25-52-29)44(67)57-36(20-27-11-6-5-7-12-27)43(66)54-33(16-10-19-50-45(47)48)41(64)56-35(39(46)62)21-28-23-51-31-15-9-8-13-30(28)31/h5-9,11-13,15,23-25,32-37,51H,3-4,10,14,16-22H2,1-2H3,(H2,46,62)(H,49,52)(H,53,59)(H,54,66)(H,55,63)(H,56,64)(H,57,67)(H,58,65)(H,60,61)(H4,47,48,50)/t32-,33-,34-,35-,36+,37-/m0/s1 UXUHFYAAKVDWBE-BWBQVKFQSA-N 50100758 Ac-Nle-Glu-His-DPhe-Arg-Trp-NH2::CHEMBL267794 Melanocortin receptor 4 Mus musculus 0.45 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100758&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10240594 103997486 CHEMBL267794 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801631 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27+,28+,29-/m0/s1 DFCJPPDAOZROBS-AUAHOFGGSA-N 50058963 Ac-His-DPhe-Arg-DTrp-NH2::Ac-His-DPhe-DArg-DTrp-NH2::CHEMBL433296 Melanocortin receptor 4 Mus musculus 154 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50058963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50058963&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9896284 103954865 CHEMBL433296 ZINC26253811 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801634 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C60H80N16O15/c1-3-4-14-41(70-59(91)49(31-78)76-56(88)46(25-35-17-19-38(80)20-18-35)74-58(90)48(30-77)68-33(2)79)52(84)71-43(21-22-50(81)82)54(86)75-47(27-37-29-64-32-67-37)57(89)73-45(24-34-11-6-5-7-12-34)55(87)69-42(16-10-23-65-60(62)63)53(85)72-44(51(61)83)26-36-28-66-40-15-9-8-13-39(36)40/h5-9,11-13,15,17-20,28-29,32,41-49,66,77-78,80H,3-4,10,14,16,21-27,30-31H2,1-2H3,(H2,61,83)(H,64,67)(H,68,79)(H,69,87)(H,70,91)(H,71,84)(H,72,85)(H,73,89)(H,74,90)(H,75,86)(H,76,88)(H,81,82)(H4,62,63,65)/t41-,42-,43-,44-,45+,46-,47-,48-,49-/m0/s1 JGQHJNHOTSHMQR-JYZGIZETSA-N 50100753 Ac-Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-NH2::CHEMBL410763 Melanocortin receptor 4 Mus musculus 0.780 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100753&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25077729 103997481 CHEMBL410763 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801638 CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C39H50N12O8/c1-22(52)47-29(13-14-33(53)54)36(57)51-32(18-25-20-43-21-46-25)38(59)50-31(16-23-8-3-2-4-9-23)37(58)48-28(12-7-15-44-39(41)42)35(56)49-30(34(40)55)17-24-19-45-27-11-6-5-10-26(24)27/h2-6,8-11,19-21,28-32,45H,7,12-18H2,1H3,(H2,40,55)(H,43,46)(H,47,52)(H,48,58)(H,49,56)(H,50,59)(H,51,57)(H,53,54)(H4,41,42,44)/t28-,29-,30-,31+,32-/m0/s1 IBSSPYAGEMWLBR-NRQMHRBESA-N 50100751 Ac-Glu-His-DPhe-Arg-Trp-NH2::CHEMBL307457 Melanocortin receptor 4 Mus musculus 4.31 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100751&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10952895 103997479 CHEMBL307457 ZINC95610176 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801643 CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(N)=O InChI=1S/C52H74N16O9/c1-30(2)44(45(54)71)67-50(76)42-19-12-22-68(42)51(77)38(17-9-10-20-53)63-43(70)28-60-46(72)40(24-33-26-59-36-16-8-7-15-35(33)36)66-47(73)37(18-11-21-58-52(55)56)64-48(74)39(23-32-13-5-4-6-14-32)65-49(75)41(62-31(3)69)25-34-27-57-29-61-34/h4-8,13-16,26-27,29-30,37-42,44,59H,9-12,17-25,28,53H2,1-3H3,(H2,54,71)(H,57,61)(H,60,72)(H,62,69)(H,63,70)(H,64,74)(H,65,75)(H,66,73)(H,67,76)(H4,55,56,58)/t37-,38-,39+,40-,41-,42-,44-/m0/s1 CZJLEWKLJVYQIZ-NTACYJAKSA-N 50100755 Ac-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL405335 Melanocortin receptor 4 Mus musculus 0.45 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100755&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10898423 103997483 CHEMBL405335 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801645 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(N)=O InChI=1S/C68H95N19O17/c1-3-4-16-47(81-67(104)55(36-89)87-64(101)51(29-40-20-22-43(91)23-21-40)84-66(103)54(35-88)78-38(2)90)60(97)82-49(24-25-57(93)94)62(99)86-53(31-42-33-73-37-77-42)65(102)83-50(28-39-13-6-5-7-14-39)63(100)80-48(19-12-27-74-68(71)72)61(98)85-52(30-41-32-75-45-17-9-8-15-44(41)45)59(96)76-34-56(92)79-46(58(70)95)18-10-11-26-69/h5-9,13-15,17,20-23,32-33,37,46-55,75,88-89,91H,3-4,10-12,16,18-19,24-31,34-36,69H2,1-2H3,(H2,70,95)(H,73,77)(H,76,96)(H,78,90)(H,79,92)(H,80,100)(H,81,104)(H,82,97)(H,83,102)(H,84,103)(H,85,98)(H,86,99)(H,87,101)(H,93,94)(H4,71,72,74)/t46-,47-,48-,49-,50+,51-,52-,53-,54-,55-/m0/s1 WAKZWGDSQCKJTJ-IJSCXIAKSA-N 50100757 Ac-Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-NH2::CHEMBL386081 Melanocortin receptor 4 Mus musculus 0.440 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100757&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25091968 103997485 CHEMBL386081 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801647 CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C28H36N8O4/c1-17(37)34-24(14-18-8-3-2-4-9-18)27(40)35-22(12-7-13-32-28(30)31)26(39)36-23(25(29)38)15-19-16-33-21-11-6-5-10-20(19)21/h2-6,8-11,16,22-24,33H,7,12-15H2,1H3,(H2,29,38)(H,34,37)(H,35,40)(H,36,39)(H4,30,31,32)/t22-,23-,24+/m0/s1 LUCUFURZWPZEOH-KMDXXIMOSA-N 50034912 (S)-2-((R)-2-Acetylamino-3-phenyl-propionylamino)-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-DPhe-Arg-Trp-NH2::CHEMBL432895 Melanocortin receptor 4 Mus musculus 2320 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034912 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034912&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10918643 103943036 CHEMBL432895 ZINC29465128 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801648 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28-,29-/m0/s1 DFCJPPDAOZROBS-DZUOILHNSA-N 50034910 (S)-2-{(S)-2-[(S)-2-acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amideAc-His-DPhe-DArg-Trp-NH2::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide(Ac-His-Phe-Arg-Trp-NH2)::Ac-His-D-Phe-Arg-D-Trp-NH2::Ac-His-DPhe-Arg-Trp-NH2::Ac-His-Phe-Arg-Trp-NH2::CHEMBL50056 Melanocortin receptor 4 Mus musculus 2110 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034910&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10484741 103943035 CHEMBL50056 ZINC27638796 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801650 CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C63H92N18O13/c1-5-6-19-43(73-37(4)82)56(88)76-45(24-25-52(84)85)58(90)79-49(31-40-33-68-35-72-40)60(92)77-47(29-38-16-8-7-9-17-38)59(91)75-44(22-14-27-69-63(66)67)57(89)78-48(30-39-32-70-42-20-11-10-18-41(39)42)55(87)71-34-51(83)74-46(21-12-13-26-64)62(94)81-28-15-23-50(81)61(93)80-53(36(2)3)54(65)86/h7-11,16-18,20,32-33,35-36,43-50,53,70H,5-6,12-15,19,21-31,34,64H2,1-4H3,(H2,65,86)(H,68,72)(H,71,87)(H,73,82)(H,74,83)(H,75,91)(H,76,88)(H,77,92)(H,78,89)(H,79,90)(H,80,93)(H,84,85)(H4,66,67,69)/t43-,44-,45-,46-,47+,48-,49-,50-,53-/m0/s1 PYBMRTRMVZCBQQ-KZTMAIBYSA-N 50100752 Ac-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL429236 Melanocortin receptor 4 Mus musculus 0.32 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100752&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10876972 103997480 CHEMBL429236 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801660 CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O InChI=1S/C47H64N14O10/c1-3-4-14-33(56-27(2)62)42(67)58-35(17-18-40(64)65)44(69)61-38(22-30-24-51-26-55-30)46(71)59-36(20-28-11-6-5-7-12-28)45(70)57-34(16-10-19-52-47(49)50)43(68)60-37(41(66)54-25-39(48)63)21-29-23-53-32-15-9-8-13-31(29)32/h5-9,11-13,15,23-24,26,33-38,53H,3-4,10,14,16-22,25H2,1-2H3,(H2,48,63)(H,51,55)(H,54,66)(H,56,62)(H,57,70)(H,58,67)(H,59,71)(H,60,68)(H,61,69)(H,64,65)(H4,49,50,52)/t33-,34-,35-,36+,37-,38-/m0/s1 ZHFBHJALAOQGNU-ZPRVLUMXSA-N 50100756 Ac-Nle-Glu-His-DPhe-Arg-Trp-Gly-NH2::CHEMBL264536 Melanocortin receptor 4 Mus musculus 0.940 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50100756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50100756&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10290587 103997484 CHEMBL264536 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50801662 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27+,28-,29-/m0/s1 DFCJPPDAOZROBS-CRNKYVSFSA-N 50058958 2-{2-[2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amideAc-His-Phe-Arg-DTrp-NH2::Ac-His-Phe-Arg-DTrp-NH2::CHEMBL302703 Melanocortin receptor 4 Mus musculus 6620 ChEMBL 10.1021/jm010061n 10.7270/Q2GB24S4 11405661 Haskell-Luevano, C; Holder, JR; Monck, EK; Bauzo, RM University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50058958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50058958&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11966875 103954860 CHEMBL302703 ZINC26250130 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805687 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C41H47N9O5/c1-25(51)47-35(22-27-17-18-28-12-5-6-13-29(28)20-27)39(54)50-36(21-26-10-3-2-4-11-26)40(55)48-33(16-9-19-45-41(43)44)38(53)49-34(37(42)52)23-30-24-46-32-15-8-7-14-31(30)32/h2-8,10-15,17-18,20,24,33-36,46H,9,16,19,21-23H2,1H3,(H2,42,52)(H,47,51)(H,48,55)(H,49,53)(H,50,54)(H4,43,44,45)/t33-,34-,35-,36+/m0/s1 KUGJWPLOGLBSEC-SKXFTCKDSA-N 50114737 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[1-methylcarboxamido-2-(2-naphthyl)-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL94369 Melanocortin receptor 4 Mus musculus 2900 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114737&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10952751 104008808 CHEMBL94369 ZINC95545553 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805690 CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C39H46N10O5/c1-23(50)46-34(20-26-22-45-30-15-8-6-13-28(26)30)38(54)49-33(18-24-10-3-2-4-11-24)37(53)47-31(16-9-17-43-39(41)42)36(52)48-32(35(40)51)19-25-21-44-29-14-7-5-12-27(25)29/h2-8,10-15,21-22,31-34,44-45H,9,16-20H2,1H3,(H2,40,51)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,41,42,43)/t31-,32-,33+,34+/m0/s1 YSBBQLMGIDMSEJ-PSWJWLENSA-N 50114738 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-3-indolyl)-1-methylcarboxamido-(1R)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL432027 Melanocortin receptor 4 Mus musculus 6200 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114738&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11147006 104008809 CHEMBL432027 ZINC26670940 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805692 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C41H47N9O5/c1-25(51)47-35(22-27-17-18-28-12-5-6-13-29(28)20-27)39(54)50-36(21-26-10-3-2-4-11-26)40(55)48-33(16-9-19-45-41(43)44)38(53)49-34(37(42)52)23-30-24-46-32-15-8-7-14-31(30)32/h2-8,10-15,17-18,20,24,33-36,46H,9,16,19,21-23H2,1H3,(H2,42,52)(H,47,51)(H,48,55)(H,49,53)(H,50,54)(H4,43,44,45)/t33-,34-,35+,36+/m0/s1 KUGJWPLOGLBSEC-CLLHQPRTSA-N 50114744 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[1-methylcarboxamido-2-(2-naphthyl)-(1R)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL329490 Melanocortin receptor 4 Mus musculus 1500 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114744&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11072679 104008815 CHEMBL329490 ZINC95611067 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805693 C[C@H](NC(C)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C31H41N9O5/c1-18(37-19(2)41)28(43)40-26(15-20-9-4-3-5-10-20)30(45)38-24(13-8-14-35-31(33)34)29(44)39-25(27(32)42)16-21-17-36-23-12-7-6-11-22(21)23/h3-7,9-12,17-18,24-26,36H,8,13-16H2,1-2H3,(H2,32,42)(H,37,41)(H,38,45)(H,39,44)(H,40,43)(H4,33,34,35)/t18-,24-,25-,26+/m0/s1 RGORAYVOQFUNIL-YCYYUTJKSA-N 50114743 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL330233 Melanocortin receptor 4 Mus musculus 1000 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114743&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11124973 104008814 CHEMBL330233 C04341 ZINC26665294 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805694 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C38H45N9O5/c1-23(48)47-22-26-13-6-5-12-25(26)20-33(47)37(52)46-32(18-24-10-3-2-4-11-24)36(51)44-30(16-9-17-42-38(40)41)35(50)45-31(34(39)49)19-27-21-43-29-15-8-7-14-28(27)29/h2-8,10-15,21,30-33,43H,9,16-20,22H2,1H3,(H2,39,49)(H,44,51)(H,45,50)(H,46,52)(H4,40,41,42)/t30-,31-,32+,33-/m0/s1 YVMNAKQQXPYPRY-SSNHPIBPSA-N 50114733 3N-[1-[4-amino(imino)methylamino-1-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethylcarbamoyl]-(1S)-butylcarbamoyl]-2-phenyl-(1R)-ethyl]-2-acetyl-(3S)-1,4-dihydro-3-isoquinolinecarboxamide::CHEMBL96871 Melanocortin receptor 4 Mus musculus 2900 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114733&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10897829 104008804 CHEMBL96871 ZINC26721320 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805698 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.21 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805710 CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29+/m0/s1 DFCJPPDAOZROBS-QUAHOIDUSA-N 50114735 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1R)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL94391 Melanocortin receptor 4 Mus musculus 506 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114735&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11050721 104008806 CHEMBL94391 ZINC26673289 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805716 CC(=O)N1Cc2ccccc2C[C@@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C38H45N9O5/c1-23(48)47-22-26-13-6-5-12-25(26)20-33(47)37(52)46-32(18-24-10-3-2-4-11-24)36(51)44-30(16-9-17-42-38(40)41)35(50)45-31(34(39)49)19-27-21-43-29-15-8-7-14-28(27)29/h2-8,10-15,21,30-33,43H,9,16-20,22H2,1H3,(H2,39,49)(H,44,51)(H,45,50)(H,46,52)(H4,40,41,42)/t30-,31-,32+,33+/m0/s1 YVMNAKQQXPYPRY-UYEZAFAQSA-N 50114734 3N-[1-[4-amino(imino)methylamino-1-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethylcarbamoyl]-(1S)-butylcarbamoyl]-2-phenyl-(1R)-ethyl]-2-acetyl-(3R)-1,4-dihydro-3-isoquinolinecarboxamide::CHEMBL275303 Melanocortin receptor 4 Mus musculus 11700 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114734&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10996121 104008805 CHEMBL275303 ZINC26722114 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805722 CC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H43N9O5S/c1-21(45)41-30(19-24-11-8-16-50-24)34(49)44-29(17-22-9-3-2-4-10-22)33(48)42-27(14-7-15-39-35(37)38)32(47)43-28(31(36)46)18-23-20-40-26-13-6-5-12-25(23)26/h2-6,8-13,16,20,27-30,40H,7,14-15,17-19H2,1H3,(H2,36,46)(H,41,45)(H,42,48)(H,43,47)(H,44,49)(H4,37,38,39)/t27-,28-,29+,30-/m0/s1 ULBOINVSOBKOSI-ZXYZSCNASA-N 50114748 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[1-methylcarboxamido-2-(2-thienyl)-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL330561 Melanocortin receptor 4 Mus musculus 91.20 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114748&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11146896 104008819 CHEMBL330561 ZINC26673444 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805723 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C39H45N9O5S/c1-23(49)45-33(20-26-22-54-34-16-8-6-13-28(26)34)38(53)48-32(18-24-10-3-2-4-11-24)37(52)46-30(15-9-17-43-39(41)42)36(51)47-31(35(40)50)19-25-21-44-29-14-7-5-12-27(25)29/h2-8,10-14,16,21-22,30-33,44H,9,15,17-20H2,1H3,(H2,40,50)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,41,42,43)/t30-,31-,32+,33-/m0/s1 SCMBDULKOAKNSG-SSNHPIBPSA-N 50114742 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-benzo[b]thiophen-3-yl-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL431092 Melanocortin receptor 4 Mus musculus 211 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114742&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10941679 104008813 CHEMBL431092 ZINC95540749 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805727 CC(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C36H44N10O5/c1-22(47)43-30(19-24-13-16-40-17-14-24)34(50)46-31(18-23-8-3-2-4-9-23)35(51)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)20-25-21-42-27-11-6-5-10-26(25)27/h2-6,8-11,13-14,16-17,21,28-31,42H,7,12,15,18-20H2,1H3,(H2,37,48)(H,43,47)(H,44,51)(H,45,49)(H,46,50)(H4,38,39,41)/t28-,29-,30-,31+/m0/s1 JXXVTKYSEJEATG-XHPANXIASA-N 50114741 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[1-methylcarboxamido-2-(4-pyridyl)-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL317968 Melanocortin receptor 4 Mus musculus 128 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114741&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11966921 104008812 CHEMBL317968 ZINC26717966 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805731 CC(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C36H44N10O5/c1-22(47)43-30(18-24-11-7-15-40-20-24)34(50)46-31(17-23-9-3-2-4-10-23)35(51)44-28(14-8-16-41-36(38)39)33(49)45-29(32(37)48)19-25-21-42-27-13-6-5-12-26(25)27/h2-7,9-13,15,20-21,28-31,42H,8,14,16-19H2,1H3,(H2,37,48)(H,43,47)(H,44,51)(H,45,49)(H,46,50)(H4,38,39,41)/t28-,29-,30-,31+/m0/s1 UIBDIGUMWQQJIJ-XHPANXIASA-N 50114746 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[1-methylcarboxamido-2-(3-pyridyl)-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL317969 Melanocortin receptor 4 Mus musculus 887 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114746&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11136229 104008817 CHEMBL317969 ZINC26717971 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805735 CC(=O)NC1(CCc2ccccc2C1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C39H47N9O5/c1-24(49)48-39(18-17-26-12-5-6-13-27(26)22-39)37(53)47-33(20-25-10-3-2-4-11-25)36(52)45-31(16-9-19-43-38(41)42)35(51)46-32(34(40)50)21-28-23-44-30-15-8-7-14-29(28)30/h2-8,10-15,23,31-33,44H,9,16-22H2,1H3,(H2,40,50)(H,45,52)(H,46,51)(H,47,53)(H,48,49)(H4,41,42,43)/t31-,32-,33+,39?/m0/s1 OQLULEULDRFDPX-BQWZEOMXSA-N 50114740 1N-{2-[1-[4-amino(imino)methylamino-1-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethylcarbamoyl]-(1S)-butylcarbamoyl]-2-phenyl-(1R)-ethylcarbamoyl]-1,2,3,4-tetrahydro-2-naphthalenyl}acetamide::CHEMBL96531 Melanocortin receptor 4 Mus musculus 714 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114740&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11828678 104008811 CHEMBL96531 ZINC26671724 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805741 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C39H46N10O5/c1-23(50)46-34(20-26-22-45-30-15-8-6-13-28(26)30)38(54)49-33(18-24-10-3-2-4-11-24)37(53)47-31(16-9-17-43-39(41)42)36(52)48-32(35(40)51)19-25-21-44-29-14-7-5-12-27(25)29/h2-8,10-15,21-22,31-34,44-45H,9,16-20H2,1H3,(H2,40,51)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,41,42,43)/t31-,32-,33+,34-/m0/s1 YSBBQLMGIDMSEJ-HVRNLMOBSA-N 50114739 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-3-indolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL432201 Melanocortin receptor 4 Mus musculus 528 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114739&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10996232 104008810 CHEMBL432201 ZINC26670944 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805745 CCCC[C@H](NC(C)=O)C(=O)N1[C@@H](CC(O)=O)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCCN)C1=O InChI=1S/C50H68N14O10/c1-3-4-16-36(58-29(2)65)48(73)64-41(25-42(66)67)47(72)63-40(24-32-27-54-28-57-32)46(71)61-38(22-30-13-6-5-7-14-30)44(69)59-35(19-12-21-55-50(52)53)43(68)62-39(23-31-26-56-34-17-9-8-15-33(31)34)45(70)60-37(49(64)74)18-10-11-20-51/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25,51H2,1-2H3,(H,54,57)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,66,67)(H4,52,53,55)/t35-,36+,37-,38+,39+,40-,41+/m1/s1 ULUABNVCTYCFOE-UHDHNNMDSA-N 50114736 CHEMBL386583::[1-(2-Acetylamino-hexanoyl)-17-(4-amino-butyl)-8-benzyl-11-(3-guanidino-propyl)-5-(3H-imidazol-4-ylmethyl)-14-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16hexaaza-cyclooctadec-2-yl]-acetic acid(MTII) Melanocortin receptor 4 Mus musculus 0.0870 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114736&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44327392 104008807 CHEMBL386583 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805747 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 17.2 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805751 CC(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C37H45N9O5/c1-23(47)43-31(19-24-11-4-2-5-12-24)35(50)46-32(20-25-13-6-3-7-14-25)36(51)44-29(17-10-18-41-37(39)40)34(49)45-30(33(38)48)21-26-22-42-28-16-9-8-15-27(26)28/h2-9,11-16,22,29-32,42H,10,17-21H2,1H3,(H2,38,48)(H,43,47)(H,44,51)(H,45,49)(H,46,50)(H4,39,40,41)/t29-,30-,31+,32+/m0/s1 MFTYXDJIYBBSIZ-GASGPIRDSA-N 50114749 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[1-methylcarboxamido-2-phenyl-(1R)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL329847 Melanocortin receptor 4 Mus musculus 2170 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114749&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11083009 104008820 CHEMBL329847 ZINC26673285 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805753 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 5.37 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805756 CC(=O)Nc1cc2ccccc2cc1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C39H43N9O5/c1-23(49)45-32-20-26-13-6-5-12-25(26)19-29(32)36(51)48-34(18-24-10-3-2-4-11-24)38(53)46-31(16-9-17-43-39(41)42)37(52)47-33(35(40)50)21-27-22-44-30-15-8-7-14-28(27)30/h2-8,10-15,19-20,22,31,33-34,44H,9,16-18,21H2,1H3,(H2,40,50)(H,45,49)(H,46,53)(H,47,52)(H,48,51)(H4,41,42,43)/t31-,33-,34+/m0/s1 HQOYMPPRYNULSG-FZCBKRAZSA-N 50114745 1N-{3-[1-[4-amino(imino)methylamino-1-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethylcarbamoyl]-(1S)-butylcarbamoyl]-2-phenyl-(1R)-ethylcarbamoyl]-2-naphthyl}acetamide::CHEMBL405174 Melanocortin receptor 4 Mus musculus 21.1 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114745&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10101361 104008816 CHEMBL405174 ZINC26673441 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805758 CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C33H43N9O5/c1-20(43)42-16-8-14-28(42)32(47)41-27(17-21-9-3-2-4-10-21)31(46)39-25(13-7-15-37-33(35)36)30(45)40-26(29(34)44)18-22-19-38-24-12-6-5-11-23(22)24/h2-6,9-12,19,25-28,38H,7-8,13-18H2,1H3,(H2,34,44)(H,39,46)(H,40,45)(H,41,47)(H4,35,36,37)/t25-,26-,27+,28-/m0/s1 NSISWBCOSAKMBT-BPXGVECKSA-N 50114750 3-{2-[1-[1-[1-acetyl-(5S)-dihydro-1H-5-pyrrolylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-4-amino(imino)methylamino-(1S)-butylcarboxamido]-2-carbamoylethyl}-1H-indole::CHEMBL320157 Melanocortin receptor 4 Mus musculus 1500 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114750&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10995854 104008821 CHEMBL320157 ZINC26670033 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805762 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C37H45N9O5/c1-23(47)43-31(19-24-11-4-2-5-12-24)35(50)46-32(20-25-13-6-3-7-14-25)36(51)44-29(17-10-18-41-37(39)40)34(49)45-30(33(38)48)21-26-22-42-28-16-9-8-15-27(26)28/h2-9,11-16,22,29-32,42H,10,17-21H2,1H3,(H2,38,48)(H,43,47)(H,44,51)(H,45,49)(H,46,50)(H4,39,40,41)/t29-,30-,31-,32+/m0/s1 MFTYXDJIYBBSIZ-RTNMLALUSA-N 50114747 1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[1-methylcarboxamido-2-phenyl-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::CHEMBL327479 Melanocortin receptor 4 Mus musculus 70.6 ChEMBL 10.1021/jm0104872 10.7270/Q27945DV 12061882 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10952584 104008818 CHEMBL327479 ZINC26673514 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805852 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C36H44N12O5/c1-20(49)45-31(15-23-18-40-19-44-23)35(53)48-30(14-22-17-43-27-10-5-3-8-25(22)27)34(52)46-28(11-6-12-41-36(38)39)33(51)47-29(32(37)50)13-21-16-42-26-9-4-2-7-24(21)26/h2-5,7-10,16-19,28-31,42-43H,6,11-15H2,1H3,(H2,37,50)(H,40,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,38,39,41)/t28-,29-,30-,31-/m0/s1 LUHDZKBXWWFQLS-ORYMTKCHSA-N 50115363 2-[2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL431242 Melanocortin receptor 4 Mus musculus 34300 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115363&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11125447 104009340 CHEMBL431242 ZINC26828752 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805856 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O6/c1-19(46)42-29(15-22-17-38-18-41-22)33(51)45-28(13-20-8-10-23(47)11-9-20)32(50)43-26(7-4-12-39-34(36)37)31(49)44-27(30(35)48)14-21-16-40-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,40,47H,4,7,12-15H2,1H3,(H2,35,48)(H,38,41)(H,42,46)(H,43,50)(H,44,49)(H,45,51)(H4,36,37,39)/t26-,27-,28-,29-/m0/s1 FGCBZBMPOFJXID-DZUOILHNSA-N 50115364 2-[2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL104880 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115364&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10919573 104009341 CHEMBL104880 ZINC26830634 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805859 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 5.37 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805863 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccncc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C33H42N12O5/c1-19(46)42-28(15-22-17-38-18-41-22)32(50)45-27(13-20-8-11-37-12-9-20)31(49)43-25(7-4-10-39-33(35)36)30(48)44-26(29(34)47)14-21-16-40-24-6-3-2-5-23(21)24/h2-3,5-6,8-9,11-12,16-18,25-28,40H,4,7,10,13-15H2,1H3,(H2,34,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,35,36,39)/t25-,26-,27-,28-/m0/s1 JNZPDTSWERXJKG-LJWNLINESA-N 50115369 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-pyridin-4-yl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL430489 Melanocortin receptor 4 Mus musculus 24400 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115369&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11814465 104009346 CHEMBL430489 ZINC26838410 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805868 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C38H45N11O5/c1-22(50)46-33(18-27-20-42-21-45-27)37(54)49-32(16-23-12-13-24-7-2-3-8-25(24)15-23)36(53)47-30(11-6-14-43-38(40)41)35(52)48-31(34(39)51)17-26-19-44-29-10-5-4-9-28(26)29/h2-5,7-10,12-13,15,19-21,30-33,44H,6,11,14,16-18H2,1H3,(H2,39,51)(H,42,45)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,40,41,43)/t30-,31-,32+,33-/m0/s1 OHBCPCNJWIQQPW-SSNHPIBPSA-N 50115362 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-naphthalen-2-yl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL103817 Melanocortin receptor 4 Mus musculus 7.78 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115362&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11039918 104009339 CHEMBL103817 ZINC26834920 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805870 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)c1ccccc1 InChI=1S/C33H41N11O5/c1-19(45)41-27(15-22-17-37-18-40-22)31(48)44-28(20-8-3-2-4-9-20)32(49)42-25(12-7-13-38-33(35)36)30(47)43-26(29(34)46)14-21-16-39-24-11-6-5-10-23(21)24/h2-6,8-11,16-18,25-28,39H,7,12-15H2,1H3,(H2,34,46)(H,37,40)(H,41,45)(H,42,49)(H,43,47)(H,44,48)(H4,35,36,38)/t25-,26-,27-,28-/m0/s1 YXCLDFLLWJXJPD-LJWNLINESA-N 50115365 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-2-phenyl-acetylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL317228 Melanocortin receptor 4 Mus musculus 40500 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115365 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115365&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11039662 104009342 CHEMBL317228 ZINC26826413 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805874 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NC1(CCc2ccccc2C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C36H45N11O5/c1-21(48)44-30(16-25-19-40-20-43-25)33(51)47-36(13-12-22-7-2-3-8-23(22)17-36)34(52)46-28(11-6-14-41-35(38)39)32(50)45-29(31(37)49)15-24-18-42-27-10-5-4-9-26(24)27/h2-5,7-10,18-20,28-30,42H,6,11-17H2,1H3,(H2,37,49)(H,40,43)(H,44,48)(H,45,50)(H,46,52)(H,47,51)(H4,38,39,41)/t28-,29-,30-,36?/m0/s1 MXPMNTOAZLMXKC-KUYBKGITSA-N 50115360 2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid {1-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butyl}-amide::CHEMBL102688 Melanocortin receptor 4 Mus musculus 1780 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115360&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44335147 104009337 CHEMBL102688 ZINC26824345 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805876 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C38H45N11O5/c1-22(50)46-33(18-26-20-42-21-45-26)37(54)49-32(16-24-10-6-9-23-8-2-3-11-27(23)24)36(53)47-30(14-7-15-43-38(40)41)35(52)48-31(34(39)51)17-25-19-44-29-13-5-4-12-28(25)29/h2-6,8-13,19-21,30-33,44H,7,14-18H2,1H3,(H2,39,51)(H,42,45)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,40,41,43)/t30-,31-,32-,33-/m0/s1 ZJZJSTFJNWUUAH-YRCZKMHPSA-N 50115374 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-naphthalen-1-yl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL319922 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115374&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11050892 104009351 CHEMBL319922 ZINC26830890 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805882 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NC1(CCc2ccccc2C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C36H45N11O5/c1-21(48)44-30(16-25-19-40-20-43-25)33(51)47-36(13-12-22-7-2-3-8-23(22)17-36)34(52)46-28(11-6-14-41-35(38)39)32(50)45-29(31(37)49)15-24-18-42-27-10-5-4-9-26(24)27/h2-5,7-10,18-20,28-30,42H,6,11-17H2,1H3,(H2,37,49)(H,40,43)(H,44,48)(H,45,50)(H,46,52)(H,47,51)(H4,38,39,41)/t28-,29-,30-,36?/m0/s1 MXPMNTOAZLMXKC-KUYBKGITSA-N 50115360 2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid {1-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butyl}-amide::CHEMBL102688 Melanocortin receptor 4 Mus musculus 7130 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115360&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44335147 104009337 CHEMBL102688 ZINC26824345 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805890 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C40H47N11O5/c1-24(52)48-33(20-28-22-44-23-47-28)38(55)51-35(34(25-11-4-2-5-12-25)26-13-6-3-7-14-26)39(56)49-31(17-10-18-45-40(42)43)37(54)50-32(36(41)53)19-27-21-46-30-16-9-8-15-29(27)30/h2-9,11-16,21-23,31-35,46H,10,17-20H2,1H3,(H2,41,53)(H,44,47)(H,48,52)(H,49,56)(H,50,54)(H,51,55)(H4,42,43,45)/t31-,32-,33-,35+/m0/s1 JDVCDJBHKUIJSL-UJWBSGRQSA-N 50115377 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3,3-diphenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL106959 Melanocortin receptor 4 Mus musculus 5000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115377 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115377&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10887200 104009354 CHEMBL106959 ZINC95546261 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805895 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H42IN11O5/c1-19(47)43-29(15-23-17-39-18-42-23)33(51)46-28(13-20-8-10-22(35)11-9-20)32(50)44-26(7-4-12-40-34(37)38)31(49)45-27(30(36)48)14-21-16-41-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,41H,4,7,12-15H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,37,38,40)/t26-,27-,28+,29-/m0/s1 OBADRSUMIBIHEX-FKWFRFQNSA-N 50115373 2-[2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-(4-iodo-phenyl)-propionylamino]-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe(pI)-Arg-Trp-NH2::CHEMBL322610 Melanocortin receptor 4 Mus musculus 25 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115373&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9875763 104009350 CHEMBL322610 ZINC95610762 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805905 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C38H45N11O5/c1-22(50)46-33(18-26-20-42-21-45-26)37(54)49-32(16-24-10-6-9-23-8-2-3-11-27(23)24)36(53)47-30(14-7-15-43-38(40)41)35(52)48-31(34(39)51)17-25-19-44-29-13-5-4-12-28(25)29/h2-6,8-13,19-21,30-33,44H,7,14-18H2,1H3,(H2,39,51)(H,42,45)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,40,41,43)/t30-,31-,32+,33-/m0/s1 ZJZJSTFJNWUUAH-SSNHPIBPSA-N 50115376 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-naphthalen-1-yl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL321870 Melanocortin receptor 4 Mus musculus 303 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115376 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115376&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10985482 104009353 CHEMBL321870 ZINC26839011 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805906 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C36H44N12O5/c1-20(49)45-31(15-23-18-40-19-44-23)35(53)48-30(14-22-17-43-27-10-5-3-8-25(22)27)34(52)46-28(11-6-12-41-36(38)39)33(51)47-29(32(37)50)13-21-16-42-26-9-4-2-7-24(21)26/h2-5,7-10,16-19,28-31,42-43H,6,11-15H2,1H3,(H2,37,50)(H,40,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,38,39,41)/t28-,29-,30+,31-/m0/s1 LUHDZKBXWWFQLS-MBEDZMRZSA-N 50115382 2-[2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL322889 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115382 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115382&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11104545 104009359 CHEMBL322889 ZINC26831561 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805908 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 17.2 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805909 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O6/c1-19(46)42-29(15-22-17-38-18-41-22)33(51)45-28(13-20-8-10-23(47)11-9-20)32(50)43-26(7-4-12-39-34(36)37)31(49)44-27(30(35)48)14-21-16-40-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,40,47H,4,7,12-15H2,1H3,(H2,35,48)(H,38,41)(H,42,46)(H,43,50)(H,44,49)(H,45,51)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 FGCBZBMPOFJXID-FKWFRFQNSA-N 50115366 2-[2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DTyr-Arg-Trp-NH2::CHEMBL105113 Melanocortin receptor 4 Mus musculus 2400 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115366&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11039787 104009343 CHEMBL105113 ZINC26828757 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805913 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C40H47N11O5/c1-24(52)48-33(20-28-22-44-23-47-28)38(55)51-35(34(25-11-4-2-5-12-25)26-13-6-3-7-14-26)39(56)49-31(17-10-18-45-40(42)43)37(54)50-32(36(41)53)19-27-21-46-30-16-9-8-15-29(27)30/h2-9,11-16,21-23,31-35,46H,10,17-20H2,1H3,(H2,41,53)(H,44,47)(H,48,52)(H,49,56)(H,50,54)(H,51,55)(H4,42,43,45)/t31-,32-,33-,35-/m0/s1 JDVCDJBHKUIJSL-TUCRWICHSA-N 50115380 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3,3-diphenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL432018 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115380 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115380&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11061667 104009357 CHEMBL432018 ZINC95614646 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805918 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)c1ccccc1 InChI=1S/C33H41N11O5/c1-19(45)41-27(15-22-17-37-18-40-22)31(48)44-28(20-8-3-2-4-9-20)32(49)42-25(12-7-13-38-33(35)36)30(47)43-26(29(34)46)14-21-16-39-24-11-6-5-10-23(21)24/h2-6,8-11,16-18,25-28,39H,7,12-15H2,1H3,(H2,34,46)(H,37,40)(H,41,45)(H,42,49)(H,43,47)(H,44,48)(H4,35,36,38)/t25-,26-,27-,28+/m0/s1 YXCLDFLLWJXJPD-LAJGZZDBSA-N 50115378 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-2-phenyl-acetylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL318119 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115378 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115378&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11767559 104009355 CHEMBL318119 ZINC26826013 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805923 C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C28H39N11O5/c1-15(36-27(44)23(37-16(2)40)11-18-13-32-14-35-18)25(42)38-21(8-5-9-33-28(30)31)26(43)39-22(24(29)41)10-17-12-34-20-7-4-3-6-19(17)20/h3-4,6-7,12-15,21-23,34H,5,8-11H2,1-2H3,(H2,29,41)(H,32,35)(H,36,44)(H,37,40)(H,38,42)(H,39,43)(H4,30,31,33)/t15-,21-,22-,23-/m0/s1 POSGXQYVXRDBTO-OBAATPRFSA-N 50115361 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL317210 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115361&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10984921 104009338 CHEMBL317210 ZINC26824334 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805925 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H43N11O5/c1-20(47)43-29(15-24-17-39-19-42-24)34(51)46-18-22-8-3-2-7-21(22)14-30(46)33(50)44-27(11-6-12-40-35(37)38)32(49)45-28(31(36)48)13-23-16-41-26-10-5-4-9-25(23)26/h2-5,7-10,16-17,19,27-30,41H,6,11-15,18H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H4,37,38,40)/t27-,28-,29-,30?/m0/s1 DOONUQVQAZPUIE-UNVCSADESA-N 50115367 (2S)-N-[(1S)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]-5-[(diaminomethylidene)amino]-2-({2-[(2S)-2-acetamido-3-(1H-imidazol-4-yl)propanoyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}formamido)pentanamide::2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {1-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butyl}-amide Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115367&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44334946 104009344 ZINC26829520 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805926 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C38H45N11O5/c1-22(50)46-33(18-27-20-42-21-45-27)37(54)49-32(16-23-12-13-24-7-2-3-8-25(24)15-23)36(53)47-30(11-6-14-43-38(40)41)35(52)48-31(34(39)51)17-26-19-44-29-10-5-4-9-28(26)29/h2-5,7-10,12-13,15,19-21,30-33,44H,6,11,14,16-18H2,1H3,(H2,39,51)(H,42,45)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,40,41,43)/t30-,31-,32-,33-/m0/s1 OHBCPCNJWIQQPW-YRCZKMHPSA-N 50115370 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-naphthalen-2-yl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL104397 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115370&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10439966 104009347 CHEMBL104397 ZINC26834924 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805931 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H45N11O5/c1-21(47)43-30(17-24-19-39-20-42-24)34(51)45-28(14-13-22-8-3-2-4-9-22)33(50)44-27(12-7-15-40-35(37)38)32(49)46-29(31(36)48)16-23-18-41-26-11-6-5-10-25(23)26/h2-6,8-11,18-20,27-30,41H,7,12-17H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,51)(H,46,49)(H4,37,38,40)/t27-,28-,29-,30-/m0/s1 KFJXIWLXGNVXSU-KRCBVYEFSA-N 50115384 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-4-phenyl-butyrylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL102391 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115384 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115384&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10865389 104009361 CHEMBL102391 ZINC26827285 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805932 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28-,29-/m0/s1 DFCJPPDAOZROBS-DZUOILHNSA-N 50034910 (S)-2-{(S)-2-[(S)-2-acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amideAc-His-DPhe-DArg-Trp-NH2::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide(Ac-His-Phe-Arg-Trp-NH2)::Ac-His-D-Phe-Arg-D-Trp-NH2::Ac-His-DPhe-Arg-Trp-NH2::Ac-His-Phe-Arg-Trp-NH2::CHEMBL50056 Melanocortin receptor 4 Mus musculus 2.11 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034910&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10484741 103943035 CHEMBL50056 ZINC27638796 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805935 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C31H41N13O5/c1-17(45)41-25(10-19-13-35-15-39-19)29(48)44-26(11-20-14-36-16-40-20)30(49)42-23(7-4-8-37-31(33)34)28(47)43-24(27(32)46)9-18-12-38-22-6-3-2-5-21(18)22/h2-3,5-6,12-16,23-26,38H,4,7-11H2,1H3,(H2,32,46)(H,35,39)(H,36,40)(H,41,45)(H,42,49)(H,43,47)(H,44,48)(H4,33,34,37)/t23-,24-,25-,26-/m0/s1 ZACRQOAPRSMDDR-CQJMVLFOSA-N 50115383 2-[2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-(3H-imidazol-4-yl)-propionylamino]-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL104010 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115383&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10865319 104009360 CHEMBL104010 ZINC26837159 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805957 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C33H42N12O5/c1-19(46)42-28(14-22-17-38-18-41-22)32(50)45-27(12-20-6-4-10-37-15-20)31(49)43-25(9-5-11-39-33(35)36)30(48)44-26(29(34)47)13-21-16-40-24-8-3-2-7-23(21)24/h2-4,6-8,10,15-18,25-28,40H,5,9,11-14H2,1H3,(H2,34,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,35,36,39)/t25-,26-,27-,28-/m0/s1 AWPSZBFASWADLU-LJWNLINESA-N 50115379 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-pyridin-3-yl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL104052 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115379 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115379&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11061440 104009356 CHEMBL104052 ZINC26838414 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805960 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H43N11O5/c1-20(47)43-29(15-24-17-39-19-42-24)34(51)46-18-22-8-3-2-7-21(22)14-30(46)33(50)44-27(11-6-12-40-35(37)38)32(49)45-28(31(36)48)13-23-16-41-26-10-5-4-9-25(23)26/h2-5,7-10,16-17,19,27-30,41H,6,11-15,18H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H4,37,38,40)/t27-,28-,29-,30?/m0/s1 DOONUQVQAZPUIE-UNVCSADESA-N 50115367 (2S)-N-[(1S)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]-5-[(diaminomethylidene)amino]-2-({2-[(2S)-2-acetamido-3-(1H-imidazol-4-yl)propanoyl]-1,2,3,4-tetrahydroisoquinolin-3-yl}formamido)pentanamide::2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid {1-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butyl}-amide Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115367 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115367&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44334946 104009344 ZINC26829520 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805962 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](CCc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H45N11O5/c1-21(47)43-30(17-24-19-39-20-42-24)34(51)45-28(14-13-22-8-3-2-4-9-22)33(50)44-27(12-7-15-40-35(37)38)32(49)46-29(31(36)48)16-23-18-41-26-11-6-5-10-25(23)26/h2-6,8-11,18-20,27-30,41H,7,12-17H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,51)(H,46,49)(H4,37,38,40)/t27-,28+,29-,30-/m0/s1 KFJXIWLXGNVXSU-XJYHXZFBSA-N 50115372 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-4-phenyl-butyrylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL430843 Melanocortin receptor 4 Mus musculus 11100 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115372 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115372&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11083039 104009349 CHEMBL430843 ZINC26826871 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805963 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C40H47N11O5/c1-24(52)48-35(20-29-22-44-23-47-29)39(56)51-34(18-25-13-15-27(16-14-25)26-8-3-2-4-9-26)38(55)49-32(12-7-17-45-40(42)43)37(54)50-33(36(41)53)19-28-21-46-31-11-6-5-10-30(28)31/h2-6,8-11,13-16,21-23,32-35,46H,7,12,17-20H2,1H3,(H2,41,53)(H,44,47)(H,48,52)(H,49,55)(H,50,54)(H,51,56)(H4,42,43,45)/t32-,33-,34+,35-/m0/s1 UBLNHOLZZIWLTH-KMSCUOMXSA-N 50115381 2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-biphenyl-4-yl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL319871 Melanocortin receptor 4 Mus musculus 68.4 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115381 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115381&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10974712 104009358 CHEMBL319871 ZINC95610606 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50805964 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.21 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809458 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28-,29-/m0/s1 DFCJPPDAOZROBS-DZUOILHNSA-N 50034910 (S)-2-{(S)-2-[(S)-2-acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amideAc-His-DPhe-DArg-Trp-NH2::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide(Ac-His-Phe-Arg-Trp-NH2)::Ac-His-D-Phe-Arg-D-Trp-NH2::Ac-His-DPhe-Arg-Trp-NH2::Ac-His-Phe-Arg-Trp-NH2::CHEMBL50056 Melanocortin receptor 4 Mus musculus 240 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034910&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10484741 103943035 CHEMBL50056 ZINC27638796 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809464 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.21 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809467 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCc2ccccc2C1)C(N)=O InChI=1S/C34H44N10O5/c1-21(45)41-28(17-25-19-38-20-40-25)30(47)43-27(16-22-8-3-2-4-9-22)29(46)42-26(12-7-15-39-33(36)37)31(48)44-34(32(35)49)14-13-23-10-5-6-11-24(23)18-34/h2-6,8-11,19-20,26-28H,7,12-18H2,1H3,(H2,35,49)(H,38,40)(H,41,45)(H,42,46)(H,43,47)(H,44,48)(H4,36,37,39)/t26-,27-,28-,34?/m0/s1 FKKJYDBNNXYKOI-XFMMDKQPSA-N 50122062 Ac-His-D-Phe-Arg-Atc-NH2::CHEMBL153420 Melanocortin receptor 4 Mus musculus 3460 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122062&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369139 104014775 CHEMBL153420 ZINC27638251 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809471 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25-,26-,27-/m0/s1 LIEAUBZBWVCSAC-FWEHEUNISA-N 50122069 Ac-His-D-Phe-Arg-D-Phe-NH2::CHEMBL154251 Melanocortin receptor 4 Mus musculus 1000 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122069 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122069&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369097 104014782 CHEMBL154251 ZINC27648243 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809472 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31+,32-,33-/m0/s1 RERCBFQKZPDEAT-YGXYGYJOSA-N 50122063 Ac-His-D-Phe-Arg-Bip-NH2::CHEMBL347364 Melanocortin receptor 4 Mus musculus 2700 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122063&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369187 104014776 CHEMBL347364 ZINC27650717 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809473 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O InChI=1S/C38H46N10O5/c1-24(49)45-33(21-29-22-42-23-44-29)37(53)48-32(20-25-9-4-2-5-10-25)36(52)46-30(13-8-18-43-38(40)41)35(51)47-31(34(39)50)19-26-14-16-28(17-15-26)27-11-6-3-7-12-27/h2-7,9-12,14-17,22-23,30-33H,8,13,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,51)(H,48,53)(H4,40,41,43)/t30-,31-,32-,33-/m0/s1 RERCBFQKZPDEAT-YRCZKMHPSA-N 50122070 Ac-His-D-Phe-Arg-D-Bip-NH2::CHEMBL348901 Melanocortin receptor 4 Mus musculus 1500 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122070 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122070&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369167 104014783 CHEMBL348901 ZINC27647665 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809479 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cnc[nH]1)C(N)=O InChI=1S/C29H40N12O5/c1-17(42)38-24(12-20-14-34-16-37-20)28(46)41-23(10-18-6-3-2-4-7-18)27(45)39-21(8-5-9-35-29(31)32)26(44)40-22(25(30)43)11-19-13-33-15-36-19/h2-4,6-7,13-16,21-24H,5,8-12H2,1H3,(H2,30,43)(H,33,36)(H,34,37)(H,38,42)(H,39,45)(H,40,44)(H,41,46)(H4,31,32,35)/t21-,22+,23-,24-/m0/s1 MRXXHRTVXCNCKC-KIHHCIJBSA-N 50122071 Ac-His-D-Phe-Arg-His-NH2::CHEMBL350012 Melanocortin receptor 4 Mus musculus 27600 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122071&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369239 104014784 CHEMBL350012 ZINC27652002 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809485 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccccc1)C(N)=O InChI=1S/C32H42N10O5/c1-20(43)39-27(17-23-18-36-19-38-23)31(47)42-26(16-22-11-6-3-7-12-22)30(46)40-24(13-8-14-37-32(34)35)29(45)41-25(28(33)44)15-21-9-4-2-5-10-21/h2-7,9-12,18-19,24-27H,8,13-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,34,35,37)/t24-,25+,26-,27-/m0/s1 LIEAUBZBWVCSAC-XUJYPJAKSA-N 50122061 Ac-His-D-Phe-Arg-Phe-NH2::CHEMBL152986 Melanocortin receptor 4 Mus musculus 7800 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122061&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369216 104014774 CHEMBL152986 ZINC27636745 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809492 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cccc2ccccc12)C(N)=O InChI=1S/C36H44N10O5/c1-22(47)43-31(19-26-20-40-21-42-26)35(51)46-30(17-23-9-3-2-4-10-23)34(50)44-28(15-8-16-41-36(38)39)33(49)45-29(32(37)48)18-25-13-7-12-24-11-5-6-14-27(24)25/h2-7,9-14,20-21,28-31H,8,15-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29-,30-,31-/m0/s1 ZOSNQMLKRGKNRN-ORYMTKCHSA-N 50122067 Ac-His-D-Phe-Arg-D-Nal(1')-NH2::CHEMBL346925 Melanocortin receptor 4 Mus musculus 5400 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122067 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122067&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44368979 104014780 CHEMBL346925 ZINC27649846 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809496 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1csc2ccccc12)C(N)=O InChI=1S/C34H42N10O5S/c1-20(45)41-28(16-23-17-38-19-40-23)33(49)44-27(14-21-8-3-2-4-9-21)32(48)42-25(11-7-13-39-34(36)37)31(47)43-26(30(35)46)15-22-18-50-29-12-6-5-10-24(22)29/h2-6,8-10,12,17-19,25-28H,7,11,13-16H2,1H3,(H2,35,46)(H,38,40)(H,41,45)(H,42,48)(H,43,47)(H,44,49)(H4,36,37,39)/t25-,26+,27-,28-/m0/s1 GDPLVOFFSHSVQV-PUHABZHSSA-N 50122074 Ac-His-D-Phe-Arg-3Bal-NH2::CHEMBL151906 Melanocortin receptor 4 Mus musculus 143 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122074 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122074&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369165 104014787 CHEMBL151906 ZINC27644313 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809511 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cccc2ccccc12)C(N)=O InChI=1S/C36H44N10O5/c1-22(47)43-31(19-26-20-40-21-42-26)35(51)46-30(17-23-9-3-2-4-10-23)34(50)44-28(15-8-16-41-36(38)39)33(49)45-29(32(37)48)18-25-13-7-12-24-11-5-6-14-27(24)25/h2-7,9-14,20-21,28-31H,8,15-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1 ZOSNQMLKRGKNRN-JVVMDBNWSA-N 50122073 Ac-His-D-Phe-Arg-Nal(1')-NH2::CHEMBL154153 Melanocortin receptor 4 Mus musculus 260 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122073 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122073&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44368898 104014786 CHEMBL154153 ZINC27652077 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809512 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC(Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27?,28-,29-/m0/s1 DFCJPPDAOZROBS-YFTKSLQMSA-N 50122059 Ac-His-D-Phe-Arg-Trp-NH2::CHEMBL152612 Melanocortin receptor 4 Mus musculus 17.2 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122059 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122059&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369234 104014772 CHEMBL152612 ZINC27638796 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809516 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29+,30-,31-/m0/s1 GWBNFTMMLYSBAT-JVVMDBNWSA-N 50122066 Ac-His-D-Phe-Arg-Nal(2')-NH2::CHEMBL357558 Melanocortin receptor 4 Mus musculus 15.8 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122066 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122066&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369098 104014779 CHEMBL357558 ZINC27642244 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809518 CC(NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(N)=O InChI=1S/C26H38N10O5/c1-15(22(27)38)33-23(39)19(9-6-10-31-26(28)29)35-24(40)20(11-17-7-4-3-5-8-17)36-25(41)21(34-16(2)37)12-18-13-30-14-32-18/h3-5,7-8,13-15,19-21H,6,9-12H2,1-2H3,(H2,27,38)(H,30,32)(H,33,39)(H,34,37)(H,35,40)(H,36,41)(H4,28,29,31)/t15?,19-,20-,21-/m0/s1 QSPZOBJUSPJZKO-IGYPZXGCSA-N 50122068 Ac-His-D-Phe-Arg-Ala-NH2::CHEMBL359318 Melanocortin receptor 4 Mus musculus 43700 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122068 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122068&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369233 104014781 CHEMBL359318 ZINC27638304 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809519 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccncc1)C(N)=O InChI=1S/C31H41N11O5/c1-19(43)39-26(16-22-17-36-18-38-22)30(47)42-25(15-20-6-3-2-4-7-20)29(46)40-23(8-5-11-37-31(33)34)28(45)41-24(27(32)44)14-21-9-12-35-13-10-21/h2-4,6-7,9-10,12-13,17-18,23-26H,5,8,11,14-16H2,1H3,(H2,32,44)(H,36,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,33,34,37)/t23-,24+,25-,26-/m0/s1 GVMPDJLBXVWWIQ-QYOOZWMWSA-N 50122075 Ac-His-D-Phe-Arg-4Pal-NH2::CHEMBL433522 Melanocortin receptor 4 Mus musculus 30000 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122075&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369166 104014788 CHEMBL433522 ZINC27647139 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809524 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(c1ccccc1)c1ccccc1)C(N)=O InChI=1S/C38H46N10O5/c1-24(49)45-31(21-28-22-42-23-44-28)37(53)47-30(20-25-12-5-2-6-13-25)36(52)46-29(18-11-19-43-38(40)41)35(51)48-33(34(39)50)32(26-14-7-3-8-15-26)27-16-9-4-10-17-27/h2-10,12-17,22-23,29-33H,11,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,53)(H,48,51)(H4,40,41,43)/t29-,30-,31-,33+/m0/s1 NHKOQCMKWPGYPI-DKWHRJCPSA-N 50122072 Ac-His-D-Phe-Arg-Dip-NH2::CHEMBL152555 Melanocortin receptor 4 Mus musculus 11600 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122072 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122072&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369099 104014785 CHEMBL152555 ZINC27639965 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809531 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(N)=O InChI=1S/C38H46N10O5/c1-24(49)45-31(21-28-22-42-23-44-28)37(53)47-30(20-25-12-5-2-6-13-25)36(52)46-29(18-11-19-43-38(40)41)35(51)48-33(34(39)50)32(26-14-7-3-8-15-26)27-16-9-4-10-17-27/h2-10,12-17,22-23,29-33H,11,18-21H2,1H3,(H2,39,50)(H,42,44)(H,45,49)(H,46,52)(H,47,53)(H,48,51)(H4,40,41,43)/t29-,30-,31-,33-/m0/s1 NHKOQCMKWPGYPI-QUUJSONZSA-N 50122058 Ac-His-D-Phe-Arg-D-Dip-NH2::CHEMBL358833 Melanocortin receptor 4 Mus musculus 7800 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122058 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122058&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369215 104014771 CHEMBL358833 ZINC27638224 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809536 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1(CCc2ccccc2C1)C(N)=O InChI=1S/C34H44N10O5/c1-21(45)41-28(17-25-19-38-20-40-25)30(47)43-27(16-22-8-3-2-4-9-22)29(46)42-26(12-7-15-39-33(36)37)31(48)44-34(32(35)49)14-13-23-10-5-6-11-24(23)18-34/h2-6,8-11,19-20,26-28H,7,12-18H2,1H3,(H2,35,49)(H,38,40)(H,41,45)(H,42,46)(H,43,47)(H,44,48)(H4,36,37,39)/t26-,27-,28-,34?/m0/s1 FKKJYDBNNXYKOI-XFMMDKQPSA-N 50122062 Ac-His-D-Phe-Arg-Atc-NH2::CHEMBL153420 Melanocortin receptor 4 Mus musculus 8800 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122062 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122062&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369139 104014775 CHEMBL153420 ZINC27638251 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809537 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1cccs1)C(N)=O InChI=1S/C30H40N10O5S/c1-18(41)37-25(14-20-16-34-17-36-20)29(45)40-24(13-19-7-3-2-4-8-19)28(44)38-22(10-5-11-35-30(32)33)27(43)39-23(26(31)42)15-21-9-6-12-46-21/h2-4,6-9,12,16-17,22-25H,5,10-11,13-15H2,1H3,(H2,31,42)(H,34,36)(H,37,41)(H,38,44)(H,39,43)(H,40,45)(H4,32,33,35)/t22-,23+,24-,25-/m0/s1 GPEVQQNWXZZSBB-NDBXHCKUSA-N 50122065 Ac-His-D-Phe-Arg-2Thi-NH2::CHEMBL349795 Melanocortin receptor 4 Mus musculus 8120 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122065 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122065&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44369140 104014778 CHEMBL349795 ZINC27651510 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809542 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C36H44N10O5/c1-22(47)43-31(19-27-20-40-21-42-27)35(51)46-30(17-23-8-3-2-4-9-23)34(50)44-28(12-7-15-41-36(38)39)33(49)45-29(32(37)48)18-24-13-14-25-10-5-6-11-26(25)16-24/h2-6,8-11,13-14,16,20-21,28-31H,7,12,15,17-19H2,1H3,(H2,37,48)(H,40,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,38,39,41)/t28-,29-,30-,31-/m0/s1 GWBNFTMMLYSBAT-ORYMTKCHSA-N 50122076 Ac-His-D-Phe-Arg-D-Nal(2')-NH2::CHEMBL347216 Melanocortin receptor 4 Mus musculus 46.20 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50122076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50122076&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44368978 104014789 CHEMBL347216 ZINC27649841 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50809545 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 5.37 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832062 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.16 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832076 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 1.93 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832161 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 1.59 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832166 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.14 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832167 CCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C48H71N11O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-26-43(60)56-42(30-36-32-52-33-55-36)47(64)59-41(28-34-21-15-14-16-22-34)46(63)57-39(25-20-27-53-48(50)51)45(62)58-40(44(49)61)29-35-31-54-38-24-19-18-23-37(35)38/h14-16,18-19,21-24,31-33,39-42,54H,2-13,17,20,25-30H2,1H3,(H2,49,61)(H,52,55)(H,56,60)(H,57,63)(H,58,62)(H,59,64)(H4,50,51,53)/t39-,40-,41+,42-/m0/s1 FTHMBGYIBAGPMD-GFUJKPJOSA-N 50166126 CHEMBL265236::Hexadecanoic acid [(S)-1-((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-amide Melanocortin receptor 4 Mus musculus 26.6 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166126&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11423083 104051534 CHEMBL265236 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832173 CCCCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C42H59N11O5/c1-2-3-4-5-6-7-11-20-37(54)50-36(24-30-26-46-27-49-30)41(58)53-35(22-28-15-9-8-10-16-28)40(57)51-33(19-14-21-47-42(44)45)39(56)52-34(38(43)55)23-29-25-48-32-18-13-12-17-31(29)32/h8-10,12-13,15-18,25-27,33-36,48H,2-7,11,14,19-24H2,1H3,(H2,43,55)(H,46,49)(H,50,54)(H,51,57)(H,52,56)(H,53,58)(H4,44,45,47)/t33-,34-,35+,36-/m0/s1 WYJVKNNXBOJBLQ-KFIZHRIMSA-N 50166129 CHEMBL426282::Decanoic acid [(S)-1-((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-amide Melanocortin receptor 4 Mus musculus 14.4 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166129&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11181928 104051537 CHEMBL426282 ZINC95614468 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832183 CCCCCCCCCCCCN[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C44H65N11O4/c1-2-3-4-5-6-7-8-9-10-16-23-49-38(27-33-29-48-30-52-33)42(58)55-39(25-31-18-12-11-13-19-31)43(59)53-36(22-17-24-50-44(46)47)41(57)54-37(40(45)56)26-32-28-51-35-21-15-14-20-34(32)35/h11-15,18-21,28-30,36-39,49,51H,2-10,16-17,22-27H2,1H3,(H2,45,56)(H,48,52)(H,53,59)(H,54,57)(H,55,58)(H4,46,47,50)/t36-,37-,38-,39+/m0/s1 FLNONEPLTTUUMZ-BTSKBWHGSA-N 50166128 (S)-2-{(R)-2-[(S)-2-Dodecylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL195468 Melanocortin receptor 4 Mus musculus 23.4 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166128&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44400403 104051536 CHEMBL195468 ZINC95541406 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832184 CCCCC(NC(C)=O)C(=O)N1[C@@H](CC(O)=O)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCCN)C1=O InChI=1S/C50H68N14O10/c1-3-4-16-36(58-29(2)65)48(73)64-41(25-42(66)67)47(72)63-40(24-32-27-54-28-57-32)46(71)61-38(22-30-13-6-5-7-14-30)44(69)59-35(19-12-21-55-50(52)53)43(68)62-39(23-31-26-56-34-17-9-8-15-33(31)34)45(70)60-37(49(64)74)18-10-11-20-51/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25,51H2,1-2H3,(H,54,57)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,66,67)(H4,52,53,55)/t35-,36?,37-,38-,39+,40-,41+/m1/s1 ULUABNVCTYCFOE-UALIOAIOSA-N 50166123 CHEMBL408600::[(2S,5R,8R,11R,14S,17R)-1-(2-Acetylamino-hexanoyl)-17-(4-amino-butyl)-8-benzyl-11-(3-guanidino-propyl)-5-(3H-imidazol-4-ylmethyl)-14-(1H-indol-3-ylmethyl)-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16hexaaza-cyclooctadec-2-yl]-acetic acid Melanocortin receptor 4 Mus musculus 0.06 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166123&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44400308 104051531 CHEMBL408600 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832185 CCCCCCCCCCCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C49H73N11O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-27-44(61)57-43(31-37-33-53-34-56-37)48(65)60-42(29-35-22-16-15-17-23-35)47(64)58-40(26-21-28-54-49(51)52)46(63)59-41(45(50)62)30-36-32-55-39-25-20-19-24-38(36)39/h15-17,19-20,22-25,32-34,40-43,55H,2-14,18,21,26-31H2,1H3,(H2,50,62)(H,53,56)(H,57,61)(H,58,64)(H,59,63)(H,60,65)(H4,51,52,54)/t40-,41-,42+,43-/m0/s1 CYIRWWLUWGUZJP-HPYHLGIWSA-N 50166131 CHEMBL191304::Heptadecanoic acid [(S)-1-((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-amide Melanocortin receptor 4 Mus musculus 21.4 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166131&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11263053 104051539 CHEMBL191304 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832186 CCCCCCCCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C46H67N11O5/c1-2-3-4-5-6-7-8-9-10-11-15-24-41(58)54-40(28-34-30-50-31-53-34)45(62)57-39(26-32-19-13-12-14-20-32)44(61)55-37(23-18-25-51-46(48)49)43(60)56-38(42(47)59)27-33-29-52-36-22-17-16-21-35(33)36/h12-14,16-17,19-22,29-31,37-40,52H,2-11,15,18,23-28H2,1H3,(H2,47,59)(H,50,53)(H,54,58)(H,55,61)(H,56,60)(H,57,62)(H4,48,49,51)/t37-,38-,39+,40-/m0/s1 DPZNJGKLXUVILJ-YOEXWAKESA-N 50166132 CHEMBL370261::Tetradecanoic acid [(S)-1-((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-amide Melanocortin receptor 4 Mus musculus 10.5 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166132&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11239907 104051540 CHEMBL370261 ZINC95612647 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832187 CCCCCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C43H61N11O5/c1-2-3-4-5-6-7-8-12-21-38(55)51-37(25-31-27-47-28-50-31)42(59)54-36(23-29-16-10-9-11-17-29)41(58)52-34(20-15-22-48-43(45)46)40(57)53-35(39(44)56)24-30-26-49-33-19-14-13-18-32(30)33/h9-11,13-14,16-19,26-28,34-37,49H,2-8,12,15,20-25H2,1H3,(H2,44,56)(H,47,50)(H,51,55)(H,52,58)(H,53,57)(H,54,59)(H4,45,46,48)/t34-,35-,36+,37-/m0/s1 KKCJAOUVBPLGAL-FBBJYXRJSA-N 50166127 CHEMBL194217::Undecanoic acid [(S)-1-((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-amide Melanocortin receptor 4 Mus musculus 19 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166127&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11787684 104051535 CHEMBL194217 ZINC95606703 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832193 CCCCCCCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C45H65N11O5/c1-2-3-4-5-6-7-8-9-10-14-23-40(57)53-39(27-33-29-49-30-52-33)44(61)56-38(25-31-18-12-11-13-19-31)43(60)54-36(22-17-24-50-45(47)48)42(59)55-37(41(46)58)26-32-28-51-35-21-16-15-20-34(32)35/h11-13,15-16,18-21,28-30,36-39,51H,2-10,14,17,22-27H2,1H3,(H2,46,58)(H,49,52)(H,53,57)(H,54,60)(H,55,59)(H,56,61)(H4,47,48,50)/t36-,37-,38+,39-/m0/s1 JRCLQINIPLXOIZ-RUPCYPOASA-N 50166133 CHEMBL190366::Tridecanoic acid [(S)-1-((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-amide Melanocortin receptor 4 Mus musculus 20.6 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166133&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11491374 104051541 CHEMBL190366 ZINC95606653 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832199 CCCCCCCCCCCCCCCCCCN[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C50H77N11O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-22-29-55-44(33-39-35-54-36-58-39)48(64)61-45(31-37-24-18-17-19-25-37)49(65)59-42(28-23-30-56-50(52)53)47(63)60-43(46(51)62)32-38-34-57-41-27-21-20-26-40(38)41/h17-21,24-27,34-36,42-45,55,57H,2-16,22-23,28-33H2,1H3,(H2,51,62)(H,54,58)(H,59,65)(H,60,63)(H,61,64)(H4,52,53,56)/t42-,43-,44-,45+/m0/s1 KLMXUFZOBSDDIW-RCFLWTTFSA-N 50166122 (S)-5-Guanidino-2-{(R)-2-[(S)-3-(3H-imidazol-4-yl)-2-octadecylamino-propionylamino]-3-phenyl-propionylamino}-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL364726 Melanocortin receptor 4 Mus musculus 13.4 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166122&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44400428 104051530 CHEMBL364726 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832201 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 10.7 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832206 CCCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C41H57N11O5/c1-2-3-4-5-6-10-19-36(53)49-35(23-29-25-45-26-48-29)40(57)52-34(21-27-14-8-7-9-15-27)39(56)50-32(18-13-20-46-41(43)44)38(55)51-33(37(42)54)22-28-24-47-31-17-12-11-16-30(28)31/h7-9,11-12,14-17,24-26,32-35,47H,2-6,10,13,18-23H2,1H3,(H2,42,54)(H,45,48)(H,49,53)(H,50,56)(H,51,55)(H,52,57)(H4,43,44,46)/t32-,33-,34+,35-/m0/s1 UHJKAYUBNMRGHO-KMSCUOMXSA-N 50166130 CHEMBL195439::Nonanoic acid [(S)-1-((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-amide Melanocortin receptor 4 Mus musculus 1.14 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166130&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11158573 104051538 CHEMBL195439 ZINC95606706 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832207 N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C32H41N11O4/c33-23(15-21-17-37-18-40-21)29(45)43-27(13-19-7-2-1-3-8-19)31(47)41-25(11-6-12-38-32(35)36)30(46)42-26(28(34)44)14-20-16-39-24-10-5-4-9-22(20)24/h1-5,7-10,16-18,23,25-27,39H,6,11-15,33H2,(H2,34,44)(H,37,40)(H,41,47)(H,42,46)(H,43,45)(H4,35,36,38)/t23-,25-,26-,27+/m0/s1 OVIZBCMXCJAPHP-PGXSJUQOSA-N 50166124 (S)-2-{(R)-2-[(S)-2-Amino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::CHEMBL370254 Melanocortin receptor 4 Mus musculus 18.5 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166124&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 20806319 104051532 CHEMBL370254 ZINC28475989 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832215 CCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C40H55N11O5/c1-2-3-4-5-9-18-35(52)48-34(22-28-24-44-25-47-28)39(56)51-33(20-26-13-7-6-8-14-26)38(55)49-31(17-12-19-45-40(42)43)37(54)50-32(36(41)53)21-27-23-46-30-16-11-10-15-29(27)30/h6-8,10-11,13-16,23-25,31-34,46H,2-5,9,12,17-22H2,1H3,(H2,41,53)(H,44,47)(H,48,52)(H,49,55)(H,50,54)(H,51,56)(H4,42,43,45)/t31-,32-,33+,34-/m0/s1 HEAWAGYKTOLXON-HVRNLMOBSA-N 50166125 CHEMBL191303::Octanoic acid [(S)-1-((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-amide Melanocortin receptor 4 Mus musculus 2.52 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166125&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10078903 104051533 CHEMBL191303 C16236 ZINC95606666 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50832223 CCCCCCCCCCCCCCC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C47H69N11O5/c1-2-3-4-5-6-7-8-9-10-11-12-16-25-42(59)55-41(29-35-31-51-32-54-35)46(63)58-40(27-33-20-14-13-15-21-33)45(62)56-38(24-19-26-52-47(49)50)44(61)57-39(43(48)60)28-34-30-53-37-23-18-17-22-36(34)37/h13-15,17-18,20-23,30-32,38-41,53H,2-12,16,19,24-29H2,1H3,(H2,48,60)(H,51,54)(H,55,59)(H,56,62)(H,57,61)(H,58,63)(H4,49,50,52)/t38-,39-,40+,41-/m0/s1 ZCYDDEYLARALIR-SHOCBOQASA-N 50166134 CHEMBL193151::Pentadecanoic acid [(S)-1-((R)-1-{(S)-1-[(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-4-guanidino-butylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(3H-imidazol-4-yl)-ethyl]-amide Melanocortin receptor 4 Mus musculus 13.2 ChEMBL 10.1021/jm0490843 10.7270/Q29K4C0B 15857138 Todorovic, A; Holder, JR; Bauzo, RM; Scott, JW; Kavanagh, R; Abdel-Malek, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50166134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50166134&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11308957 104051542 CHEMBL193151 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820918 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](CC(=O)NC(NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NN[C@H]1Cc2ccc(O)cc2NC1=O InChI=1S/C73H85N21O17/c1-37-62(100)84-52(27-39-13-6-3-7-14-39)68(106)90-61(71(109)94-91-50(60(99)72(110)111)25-40-18-21-44(95)22-19-40)89-59(98)33-57(93-92-56-28-41-20-23-45(96)31-49(41)83-69(56)107)70(108)87-54(30-43-35-77-36-80-43)67(105)85-51(26-38-11-4-2-5-12-38)65(103)82-48(17-10-24-78-73(75)76)63(101)86-53(29-42-34-79-47-16-9-8-15-46(42)47)66(104)88-55(32-58(74)97)64(102)81-37/h2-9,11-16,18-23,31,34-37,48,50-57,61,79,91-93,95-96H,10,17,24-30,32-33H2,1H3,(H2,74,97)(H,77,80)(H,81,102)(H,82,103)(H,83,107)(H,84,100)(H,85,105)(H,86,101)(H,87,108)(H,88,104)(H,89,98)(H,90,106)(H,94,109)(H,110,111)(H4,75,76,78)/t37-,48+,50-,51+,52+,53-,54+,55+,56-,57+,61?/m0/s1 IURJLDFCJBKSNA-YVLNVRPBSA-N 50144869 CHEMBL411775::Tyr-c[Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 0.96 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144869&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932907 104033894 CHEMBL411775 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820920 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)NC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)76-45(17-10-26-73-68(70)71)59(94)78-48(29-37-13-6-3-7-14-37)61(96)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,97)(H,77,93)(H,78,94)(H,79,98)(H,80,96)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47+,48+,49-,50+,51-,52-,57?/m0/s1 XEZOOYRFZJZPBS-UOCTVQLESA-N 50144870 CHEMBL410091::Tyr-c[Asp-Trp-Arg-DPhe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus >10000 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144870&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932908 104033895 CHEMBL410091 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820925 CC(C)C[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)ONCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O InChI=1S/C50H69N15O10/c1-28(2)20-37(59-29(3)66)45(70)65-41-24-42(67)75-58-19-10-9-16-35(43(51)68)60-47(72)39(22-31-25-56-34-15-8-7-14-33(31)34)63-44(69)36(17-11-18-55-50(52)53)61-46(71)38(21-30-12-5-4-6-13-30)62-48(73)40(64-49(41)74)23-32-26-54-27-57-32/h4-8,12-15,25-28,35-41,56,58H,9-11,16-24H2,1-3H3,(H2,51,68)(H,54,57)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,69)(H,64,74)(H,65,70)(H4,52,53,55)/t35-,36+,37+,38+,39-,40+,41+/m1/s1 AQZUWHBMAIRHAI-ZVMIYURWSA-N 50144873 Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Gly-Lys]-NH2::CHEMBL216295 Melanocortin receptor 4 Mus musculus 0.0870 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144873&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310104 104033898 CHEMBL216295 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820928 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](CC(=O)NC(NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NN[C@H]1Cc2ccc(O)cc2NC1=O InChI=1S/C73H85N21O17/c1-37-62(100)84-52(27-39-13-6-3-7-14-39)68(106)90-61(71(109)94-91-50(60(99)72(110)111)25-40-18-21-44(95)22-19-40)89-59(98)33-57(93-92-56-28-41-20-23-45(96)31-49(41)83-69(56)107)70(108)87-54(30-43-35-77-36-80-43)67(105)85-51(26-38-11-4-2-5-12-38)65(103)82-48(17-10-24-78-73(75)76)63(101)86-53(29-42-34-79-47-16-9-8-15-46(42)47)66(104)88-55(32-58(74)97)64(102)81-37/h2-9,11-16,18-23,31,34-37,48,50-57,61,79,91-93,95-96H,10,17,24-30,32-33H2,1H3,(H2,74,97)(H,77,80)(H,81,102)(H,82,103)(H,83,107)(H,84,100)(H,85,105)(H,86,101)(H,87,108)(H,88,104)(H,89,98)(H,90,106)(H,94,109)(H,110,111)(H4,75,76,78)/t37-,48+,50-,51+,52+,53-,54+,55+,56-,57+,61?/m0/s1 IURJLDFCJBKSNA-YVLNVRPBSA-N 50144869 CHEMBL411775::Tyr-c[Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 0.26 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144869&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932907 104033894 CHEMBL411775 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820934 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](CC(=O)NC(NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NN[C@H]1Cc2ccc(O)cc2NC1=O InChI=1S/C71H84N20O17/c1-37-60(97)81-51(29-40-16-9-4-10-17-40)66(103)87-59(69(106)91-88-48(58(96)70(107)108)26-41-19-22-44(92)23-20-41)86-57(95)34-55(90-89-54-30-42-21-24-45(93)32-47(42)80-67(54)104)68(105)84-52(31-43-35-75-36-77-43)65(102)79-46(18-11-25-76-71(73)74)61(98)82-49(27-38-12-5-2-6-13-38)63(100)83-50(28-39-14-7-3-8-15-39)64(101)85-53(33-56(72)94)62(99)78-37/h2-10,12-17,19-24,32,35-37,46,48-55,59,88-90,92-93H,11,18,25-31,33-34H2,1H3,(H2,72,94)(H,75,77)(H,78,99)(H,79,102)(H,80,104)(H,81,97)(H,82,98)(H,83,100)(H,84,105)(H,85,101)(H,86,95)(H,87,103)(H,91,106)(H,107,108)(H4,73,74,76)/t37-,46-,48-,49+,50-,51+,52+,53+,54-,55+,59?/m0/s1 BXRPCYASTSTGKR-FHJBMNMKSA-N 50144875 CHEMBL414900::Tyr-c[Asp-His-Arg-Phe-Phe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144875&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932910 104033900 CHEMBL414900 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820935 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 4.22 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820938 C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)NC(NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)78-48(29-37-13-6-3-7-14-37)61(96)76-45(17-10-26-73-68(70)71)59(94)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,96)(H,77,93)(H,78,98)(H,79,94)(H,80,97)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47-,48+,49-,50+,51-,52-,57?/m1/s1 BXPSHOXUOUAVOO-DTLZHJRJSA-N 50144879 CHEMBL406550::Tyr-c[Asp-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 3100 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144879&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932912 104033904 CHEMBL406550 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820939 CC(C)C[C@@H]1NC(=O)[C@@H]2CSSSSC[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSSSSC[C@H](NNC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4c[nH]cn4)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N2)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSSSC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC3=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C(C)C)[C@@H](C)O InChI=1S/C169H244N50O47S16/c1-80(2)58-103-138(238)184-69-127(228)189-100(47-50-124(170)225)141(241)192-101(48-51-125(171)226)143(243)214-131(83(7)8)166(266)219-57-27-38-123(219)162(262)211-119-76-272-279-275-267-71-114(153(253)190-97(133(233)134(173)234)34-23-53-181-167(174)175)206-149(249)108(63-92-39-43-95(223)44-40-92)200-156(256)116-73-269-277-276-268-72-115(154(254)191-98(35-24-54-182-168(176)177)139(239)198-106(61-90-30-19-15-20-31-90)146(246)199-107(62-91-32-21-16-22-33-91)147(247)203-111(66-126(172)227)144(244)187-85(10)136(236)195-105(148(248)208-116)60-89-28-17-14-18-29-89)207-150(250)109(64-93-41-45-96(224)46-42-93)201-157(257)120-77-273-280-278-270-74-117(155(255)196-103)209-152(252)113(70-220)205-142(242)102(49-52-128(229)230)193-151(251)110(65-94-68-180-79-185-94)202-145(245)104(59-81(3)4)197-140(240)99(36-25-55-183-169(178)179)194-163(263)130(82(5)6)213-160(260)121(217-216-88(13)222)78-274-282-281-271-75-118(210-159(119)259)158(258)204-112(67-129(231)232)165(265)218-56-26-37-122(218)161(261)188-84(9)135(235)186-86(11)137(237)215-132(87(12)221)164(264)212-120/h14-22,28-33,39-46,68,79-87,97-123,130-132,217,220-221,223-224H,23-27,34-38,47-67,69-78H2,1-13H3,(H2,170,225)(H2,171,226)(H2,172,227)(H2,173,234)(H,180,185)(H,184,238)(H,186,235)(H,187,244)(H,188,261)(H,189,228)(H,190,253)(H,191,254)(H,192,241)(H,193,251)(H,194,263)(H,195,236)(H,196,255)(H,197,240)(H,198,239)(H,199,246)(H,200,256)(H,201,257)(H,202,245)(H,203,247)(H,204,258)(H,205,242)(H,206,249)(H,207,250)(H,208,248)(H,209,252)(H,210,259)(H,211,262)(H,212,264)(H,213,260)(H,214,243)(H,215,237)(H,216,222)(H,229,230)(H,231,232)(H4,174,175,181)(H4,176,177,182)(H4,178,179,183)/t84-,85-,86-,87+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,130-,131-,132-/m0/s1 MYQDHXIMPMJXBQ-MNQAAEEESA-N 50144871 CHEMBL428134 Melanocortin receptor 4 Mus musculus 4.74 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144871&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310103 104033896 CHEMBL428134 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820940 C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)NC(NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)78-48(29-37-13-6-3-7-14-37)61(96)76-45(17-10-26-73-68(70)71)59(94)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,96)(H,77,93)(H,78,98)(H,79,94)(H,80,97)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47-,48+,49-,50+,51-,52-,57?/m1/s1 BXPSHOXUOUAVOO-DTLZHJRJSA-N 50144879 CHEMBL406550::Tyr-c[Asp-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 450 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144879&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932912 104033904 CHEMBL406550 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820941 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](CC(=O)NC(NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NN[C@H]1Cc2ccc(O)cc2NC1=O InChI=1S/C73H85N21O17/c1-37-62(100)84-52(27-39-13-6-3-7-14-39)68(106)90-61(71(109)94-91-50(60(99)72(110)111)25-40-18-21-44(95)22-19-40)89-59(98)33-57(93-92-56-28-41-20-23-45(96)31-49(41)83-69(56)107)70(108)87-54(30-43-35-77-36-80-43)67(105)85-51(26-38-11-4-2-5-12-38)65(103)82-48(17-10-24-78-73(75)76)63(101)86-53(29-42-34-79-47-16-9-8-15-46(42)47)66(104)88-55(32-58(74)97)64(102)81-37/h2-9,11-16,18-23,31,34-37,48,50-57,61,79,91-93,95-96H,10,17,24-30,32-33H2,1H3,(H2,74,97)(H,77,80)(H,81,102)(H,82,103)(H,83,107)(H,84,100)(H,85,105)(H,86,101)(H,87,108)(H,88,104)(H,89,98)(H,90,106)(H,94,109)(H,110,111)(H4,75,76,78)/t37-,48+,50-,51-,52+,53-,54+,55+,56-,57+,61?/m0/s1 IURJLDFCJBKSNA-SMZVWYTNSA-N 50144880 CHEMBL406032::Tyr-c[Asp-His-Phe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 57.1 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144880&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932913 104033905 CHEMBL406032 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820942 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)NC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)76-45(17-10-26-73-68(70)71)59(94)78-48(29-37-13-6-3-7-14-37)61(96)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,97)(H,77,93)(H,78,94)(H,79,98)(H,80,96)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47+,48+,49-,50+,51-,52-,57?/m0/s1 XEZOOYRFZJZPBS-UOCTVQLESA-N 50144870 CHEMBL410091::Tyr-c[Asp-Trp-Arg-DPhe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus >10000 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144870&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932908 104033895 CHEMBL410091 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820943 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 5.37 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820948 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(=O)NC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C66H79N17O16/c1-35-57(91)75-45(29-36-12-5-2-6-13-36)54(89)64(98)81-56(65(99)83-82-46(53(88)55(69)90)30-40-21-25-42(85)26-22-40)80-52(87)34-50(76-58(92)43(67)28-39-19-23-41(84)24-20-39)63(97)74-44(18-11-27-72-66(70)71)59(93)77-47(31-37-14-7-3-8-15-37)61(95)78-48(32-38-16-9-4-10-17-38)62(96)79-49(33-51(68)86)60(94)73-35/h2-10,12-17,19-26,35,43-50,56,82,84-85H,11,18,27-34,67H2,1H3,(H2,68,86)(H2,69,90)(H,73,94)(H,74,97)(H,75,91)(H,76,92)(H,77,93)(H,78,95)(H,79,96)(H,80,87)(H,81,98)(H,83,99)(H4,70,71,72)/t35-,43-,44-,45+,46+,47+,48-,49+,50-,56?/m0/s1 IACONDRWYPLPQZ-WKNXYHTMSA-N 50144878 CHEMBL402258::Tyr-c[Asp-Arg-Phe-Phe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 4800 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144878&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932911 104033903 CHEMBL402258 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820949 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(=O)NC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C66H79N17O16/c1-35-57(91)75-45(29-36-12-5-2-6-13-36)54(89)64(98)81-56(65(99)83-82-46(53(88)55(69)90)30-40-21-25-42(85)26-22-40)80-52(87)34-50(76-58(92)43(67)28-39-19-23-41(84)24-20-39)63(97)74-44(18-11-27-72-66(70)71)59(93)77-47(31-37-14-7-3-8-15-37)61(95)78-48(32-38-16-9-4-10-17-38)62(96)79-49(33-51(68)86)60(94)73-35/h2-10,12-17,19-26,35,43-50,56,82,84-85H,11,18,27-34,67H2,1H3,(H2,68,86)(H2,69,90)(H,73,94)(H,74,97)(H,75,91)(H,76,92)(H,77,93)(H,78,95)(H,79,96)(H,80,87)(H,81,98)(H,83,99)(H4,70,71,72)/t35-,43-,44-,45+,46+,47+,48-,49+,50-,56?/m0/s1 IACONDRWYPLPQZ-WKNXYHTMSA-N 50144878 CHEMBL402258::Tyr-c[Asp-Arg-Phe-Phe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 3200 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144878&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932911 104033903 CHEMBL402258 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820951 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](CC(=O)NC(NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NN[C@H]1Cc2ccc(O)cc2NC1=O InChI=1S/C73H85N21O17/c1-37-62(100)84-52(27-39-13-6-3-7-14-39)68(106)90-61(71(109)94-91-50(60(99)72(110)111)25-40-18-21-44(95)22-19-40)89-59(98)33-57(93-92-56-28-41-20-23-45(96)31-49(41)83-69(56)107)70(108)87-54(30-43-35-77-36-80-43)67(105)85-51(26-38-11-4-2-5-12-38)65(103)82-48(17-10-24-78-73(75)76)63(101)86-53(29-42-34-79-47-16-9-8-15-46(42)47)66(104)88-55(32-58(74)97)64(102)81-37/h2-9,11-16,18-23,31,34-37,48,50-57,61,79,91-93,95-96H,10,17,24-30,32-33H2,1H3,(H2,74,97)(H,77,80)(H,81,102)(H,82,103)(H,83,107)(H,84,100)(H,85,105)(H,86,101)(H,87,108)(H,88,104)(H,89,98)(H,90,106)(H,94,109)(H,110,111)(H4,75,76,78)/t37-,48+,50-,51-,52+,53-,54+,55+,56-,57+,61?/m0/s1 IURJLDFCJBKSNA-SMZVWYTNSA-N 50144880 CHEMBL406032::Tyr-c[Asp-His-Phe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 290 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144880&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932913 104033905 CHEMBL406032 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820952 CC(C)C[C@@H]1NC(=O)[C@@H]2CSSSSC[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSSSSC[C@H](NNC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4c[nH]cn4)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N2)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSSSC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC3=O)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)NN(Cc3ccccc3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C(C)C)[C@@H](C)O InChI=1S/C176H251N55O48S16/c1-83(2)57-109-144(250)193-70-133(240)199-106(46-49-130(177)237)147(253)201-107(47-50-131(178)238)149(255)224-137(86(7)8)172(278)230-56-26-37-129(230)168(274)220-125-78-285-292-288-280-73-120(158(264)200-103(139(245)140(180)246)33-22-52-189-173(181)182)215-153(259)112(60-93-38-42-99(235)43-39-93)207-160(266)121-74-281-289-290-282-75-122(161(267)211-116(64-98-69-188-82-195-98)166(272)228-231(71-95-29-18-15-19-30-95)176(279)222-105(35-24-54-191-175(185)186)146(252)209-114(62-96-67-192-102-32-21-20-31-101(96)102)155(261)212-117(65-132(179)239)150(256)197-88(10)142(248)204-111(152(258)216-121)59-92-27-16-14-17-28-92)217-154(260)113(61-94-40-44-100(236)45-41-94)208-162(268)126-79-286-293-291-283-76-123(159(265)205-109)218-157(263)119(72-232)214-148(254)108(48-51-134(241)242)202-156(262)115(63-97-68-187-81-194-97)210-151(257)110(58-84(3)4)206-145(251)104(34-23-53-190-174(183)184)203-169(275)136(85(5)6)223-165(271)127(227-226-91(13)234)80-287-295-294-284-77-124(219-164(125)270)163(269)213-118(66-135(243)244)171(277)229-55-25-36-128(229)167(273)198-87(9)141(247)196-89(11)143(249)225-138(90(12)233)170(276)221-126/h14-21,27-32,38-45,67-69,81-90,103-129,136-138,192,227,232-233,235-236H,22-26,33-37,46-66,70-80H2,1-13H3,(H2,177,237)(H2,178,238)(H2,179,239)(H2,180,246)(H,187,194)(H,188,195)(H,193,250)(H,196,247)(H,197,256)(H,198,273)(H,199,240)(H,200,264)(H,201,253)(H,202,262)(H,203,275)(H,204,248)(H,205,265)(H,206,251)(H,207,266)(H,208,268)(H,209,252)(H,210,257)(H,211,267)(H,212,261)(H,213,269)(H,214,254)(H,215,259)(H,216,258)(H,217,260)(H,218,263)(H,219,270)(H,220,274)(H,221,276)(H,222,279)(H,223,271)(H,224,255)(H,225,249)(H,226,234)(H,228,272)(H,241,242)(H,243,244)(H4,181,182,189)(H4,183,184,190)(H4,185,186,191)/t87-,88-,89-,90+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,136-,137-,138-/m0/s1 VXPXNPZGHGRGER-GVUQCVNKSA-N 50144877 CHEMBL269274 Melanocortin receptor 4 Mus musculus 1.46 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144877&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310344 104033902 CHEMBL269274 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820956 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)NC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)76-45(17-10-26-73-68(70)71)59(94)78-48(29-37-13-6-3-7-14-37)61(96)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,97)(H,77,93)(H,78,94)(H,79,98)(H,80,96)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47+,48-,49-,50+,51-,52-,57?/m0/s1 XEZOOYRFZJZPBS-AGAQULSSSA-N 50144881 CHEMBL413465::Tyr-c[Asp-Trp-Arg-Phe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 15900 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144881&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932914 104033906 CHEMBL413465 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820958 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)NC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)76-45(17-10-26-73-68(70)71)59(94)78-48(29-37-13-6-3-7-14-37)61(96)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,97)(H,77,93)(H,78,94)(H,79,98)(H,80,96)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47+,48-,49-,50+,51-,52-,57?/m0/s1 XEZOOYRFZJZPBS-AGAQULSSSA-N 50144881 CHEMBL413465::Tyr-c[Asp-Trp-Arg-Phe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 10300 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144881&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932914 104033906 CHEMBL413465 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820962 CSCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CSSSSC[C@@H]3NC(=O)[C@@H]4CCCN4C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@@H]5CCCN5C(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSSSSC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2)C(C)C)[C@@H](C)O InChI=1S/C217H327N65O62S21/c1-102(2)74-131-174(304)238-88-162(295)275-167(110(14)285)208(338)242-108(12)170(300)244-130(64-73-345-17)182(312)262-141(84-160(223)293)210(340)280-70-33-47-154(280)205(335)272-151(202(332)265-143(89-283)193(323)246-126(46-32-69-236-217(230)231)183(313)279-169(112(16)287)213(343)344)98-353-363-358-347-92-145-195(325)241-109(13)172(302)278-168(111(15)286)209(339)274-153-100-355-365-362-352-96-149-198(328)254-132(75-103(3)4)175(305)237-87-161(294)243-127(58-61-157(220)290)180(310)249-128(59-62-158(221)291)184(314)277-166(106(9)10)212(342)282-72-35-49-156(282)206(336)273-152(203(333)270-150(201(331)263-142(85-164(298)299)211(341)281-71-34-48-155(281)204(334)271-145)97-348-357-356-346-91-121(219)173(303)276-165(105(7)8)207(337)251-125(45-31-68-235-216(228)229)179(309)255-133(76-104(5)6)186(316)260-139(82-118-86-232-101-239-118)192(322)250-129(60-63-163(296)297)181(311)264-144(90-284)194(324)269-149)99-354-364-360-350-93-146(196(326)247-123(43-29-66-233-214(224)225)176(306)245-122(177(307)253-131)42-27-28-65-218)266-190(320)137(80-116-50-54-119(288)55-51-116)258-199(329)148-95-351-361-359-349-94-147(267-191(321)138(259-200(153)330)81-117-52-56-120(289)57-53-117)197(327)248-124(44-30-67-234-215(226)227)178(308)256-135(78-114-38-23-19-24-39-114)187(317)257-136(79-115-40-25-20-26-41-115)188(318)261-140(83-159(222)292)185(315)240-107(11)171(301)252-134(189(319)268-148)77-113-36-21-18-22-37-113/h18-26,36-41,50-57,86,101-112,121-156,165-169,283-289H,27-35,42-49,58-85,87-100,218-219H2,1-17H3,(H2,220,290)(H2,221,291)(H2,222,292)(H2,223,293)(H,232,239)(H,237,305)(H,238,304)(H,240,315)(H,241,325)(H,242,338)(H,243,294)(H,244,300)(H,245,306)(H,246,323)(H,247,326)(H,248,327)(H,249,310)(H,250,322)(H,251,337)(H,252,301)(H,253,307)(H,254,328)(H,255,309)(H,256,308)(H,257,317)(H,258,329)(H,259,330)(H,260,316)(H,261,318)(H,262,312)(H,263,331)(H,264,311)(H,265,332)(H,266,320)(H,267,321)(H,268,319)(H,269,324)(H,270,333)(H,271,334)(H,272,335)(H,273,336)(H,274,339)(H,275,295)(H,276,303)(H,277,314)(H,278,302)(H,279,313)(H,296,297)(H,298,299)(H,343,344)(H4,224,225,233)(H4,226,227,234)(H4,228,229,235)(H4,230,231,236)/t107-,108-,109-,110+,111+,112+,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,165-,166-,167-,168-,169-/m0/s1 ZLKHOOSBNUOOBR-LXDMXSLBSA-N 50144882 CHEMBL266288 Melanocortin receptor 4 Mus musculus 9.4 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144882&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310343 104033907 CHEMBL266288 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820963 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)NC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)76-45(17-10-26-73-68(70)71)59(94)78-48(29-37-13-6-3-7-14-37)61(96)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,97)(H,77,93)(H,78,94)(H,79,98)(H,80,96)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47+,48+,49-,50+,51-,52-,57?/m0/s1 XEZOOYRFZJZPBS-UOCTVQLESA-N 50144870 CHEMBL410091::Tyr-c[Asp-Trp-Arg-DPhe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 10900 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144870&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932908 104033895 CHEMBL410091 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820964 CSCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]2CSSSSC[C@@H]3NC(=O)[C@@H]4CCCN4C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]4CSSSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@@H]5CCCN5C(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSSSSC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CSSSSC[C@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCCN=C(N)N)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2)C(C)C)[C@@H](C)O InChI=1S/C217H327N65O62S21/c1-102(2)74-131-174(304)238-88-162(295)275-167(110(14)285)208(338)242-108(12)170(300)244-130(64-73-345-17)182(312)262-141(84-160(223)293)210(340)280-70-33-47-154(280)205(335)272-151(202(332)265-143(89-283)193(323)246-126(46-32-69-236-217(230)231)183(313)279-169(112(16)287)213(343)344)98-353-363-358-347-92-145-195(325)241-109(13)172(302)278-168(111(15)286)209(339)274-153-100-355-365-362-352-96-149-198(328)254-132(75-103(3)4)175(305)237-87-161(294)243-127(58-61-157(220)290)180(310)249-128(59-62-158(221)291)184(314)277-166(106(9)10)212(342)282-72-35-49-156(282)206(336)273-152(203(333)270-150(201(331)263-142(85-164(298)299)211(341)281-71-34-48-155(281)204(334)271-145)97-348-357-356-346-91-121(219)173(303)276-165(105(7)8)207(337)251-125(45-31-68-235-216(228)229)179(309)255-133(76-104(5)6)186(316)260-139(82-118-86-232-101-239-118)192(322)250-129(60-63-163(296)297)181(311)264-144(90-284)194(324)269-149)99-354-364-360-350-93-146(196(326)247-123(43-29-66-233-214(224)225)176(306)245-122(177(307)253-131)42-27-28-65-218)266-190(320)137(80-116-50-54-119(288)55-51-116)258-199(329)148-95-351-361-359-349-94-147(267-191(321)138(259-200(153)330)81-117-52-56-120(289)57-53-117)197(327)248-124(44-30-67-234-215(226)227)178(308)256-135(78-114-38-23-19-24-39-114)187(317)257-136(79-115-40-25-20-26-41-115)188(318)261-140(83-159(222)292)185(315)240-107(11)171(301)252-134(189(319)268-148)77-113-36-21-18-22-37-113/h18-26,36-41,50-57,86,101-112,121-156,165-169,283-289H,27-35,42-49,58-85,87-100,218-219H2,1-17H3,(H2,220,290)(H2,221,291)(H2,222,292)(H2,223,293)(H,232,239)(H,237,305)(H,238,304)(H,240,315)(H,241,325)(H,242,338)(H,243,294)(H,244,300)(H,245,306)(H,246,323)(H,247,326)(H,248,327)(H,249,310)(H,250,322)(H,251,337)(H,252,301)(H,253,307)(H,254,328)(H,255,309)(H,256,308)(H,257,317)(H,258,329)(H,259,330)(H,260,316)(H,261,318)(H,262,312)(H,263,331)(H,264,311)(H,265,332)(H,266,320)(H,267,321)(H,268,319)(H,269,324)(H,270,333)(H,271,334)(H,272,335)(H,273,336)(H,274,339)(H,275,295)(H,276,303)(H,277,314)(H,278,302)(H,279,313)(H,296,297)(H,298,299)(H,343,344)(H4,224,225,233)(H4,226,227,234)(H4,228,229,235)(H4,230,231,236)/t107-,108-,109-,110+,111+,112+,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,165-,166-,167-,168-,169-/m0/s1 ZLKHOOSBNUOOBR-LXDMXSLBSA-N 50144882 CHEMBL266288 Melanocortin receptor 4 Mus musculus 5.48 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144882&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310343 104033907 CHEMBL266288 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820965 C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)NC(NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)78-48(29-37-13-6-3-7-14-37)61(96)76-45(17-10-26-73-68(70)71)59(94)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,96)(H,77,93)(H,78,98)(H,79,94)(H,80,97)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47-,48+,49-,50+,51-,52-,57?/m1/s1 BXPSHOXUOUAVOO-DTLZHJRJSA-N 50144879 CHEMBL406550::Tyr-c[Asp-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 6800 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144879&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932912 104033904 CHEMBL406550 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820966 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](CC(=O)NC(NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NN[C@H]1Cc2ccc(O)cc2NC1=O InChI=1S/C73H85N21O17/c1-37-62(100)84-52(27-39-13-6-3-7-14-39)68(106)90-61(71(109)94-91-50(60(99)72(110)111)25-40-18-21-44(95)22-19-40)89-59(98)33-57(93-92-56-28-41-20-23-45(96)31-49(41)83-69(56)107)70(108)87-54(30-43-35-77-36-80-43)67(105)85-51(26-38-11-4-2-5-12-38)65(103)82-48(17-10-24-78-73(75)76)63(101)86-53(29-42-34-79-47-16-9-8-15-46(42)47)66(104)88-55(32-58(74)97)64(102)81-37/h2-9,11-16,18-23,31,34-37,48,50-57,61,79,91-93,95-96H,10,17,24-30,32-33H2,1H3,(H2,74,97)(H,77,80)(H,81,102)(H,82,103)(H,83,107)(H,84,100)(H,85,105)(H,86,101)(H,87,108)(H,88,104)(H,89,98)(H,90,106)(H,94,109)(H,110,111)(H4,75,76,78)/t37-,48+,50-,51+,52+,53-,54+,55+,56-,57+,61?/m0/s1 IURJLDFCJBKSNA-YVLNVRPBSA-N 50144869 CHEMBL411775::Tyr-c[Asp-His-DPhe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 0.18 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144869&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932907 104033894 CHEMBL411775 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820969 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)NC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)76-45(17-10-26-73-68(70)71)59(94)78-48(29-37-13-6-3-7-14-37)61(96)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,97)(H,77,93)(H,78,94)(H,79,98)(H,80,96)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47+,48-,49-,50+,51-,52-,57?/m0/s1 XEZOOYRFZJZPBS-AGAQULSSSA-N 50144881 CHEMBL413465::Tyr-c[Asp-Trp-Arg-Phe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 7300 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144881&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932914 104033906 CHEMBL413465 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820974 C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)NC(NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)78-48(29-37-13-6-3-7-14-37)61(96)76-45(17-10-26-73-68(70)71)59(94)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,96)(H,77,93)(H,78,98)(H,79,94)(H,80,97)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47-,48-,49-,50+,51-,52+,57?/m1/s1 BXPSHOXUOUAVOO-XLFZXRFMSA-N 50144874 CHEMBL440633::Tyr-c[Asp-Phe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 13400 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144874&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932909 104033899 CHEMBL440633 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820976 CC(C)C[C@@H]1NC(=O)[C@@H]2CSSSSC[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSSSSC[C@H](NNC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4c[nH]cn4)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N2)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSSSC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC3=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C(C)C)[C@@H](C)O InChI=1S/C169H244N50O47S16/c1-80(2)58-103-138(238)184-69-127(228)189-100(47-50-124(170)225)141(241)192-101(48-51-125(171)226)143(243)214-131(83(7)8)166(266)219-57-27-38-123(219)162(262)211-119-76-272-279-275-267-71-114(153(253)190-97(133(233)134(173)234)34-23-53-181-167(174)175)206-149(249)108(63-92-39-43-95(223)44-40-92)200-156(256)116-73-269-277-276-268-72-115(154(254)191-98(35-24-54-182-168(176)177)139(239)198-106(61-90-30-19-15-20-31-90)146(246)199-107(62-91-32-21-16-22-33-91)147(247)203-111(66-126(172)227)144(244)187-85(10)136(236)195-105(148(248)208-116)60-89-28-17-14-18-29-89)207-150(250)109(64-93-41-45-96(224)46-42-93)201-157(257)120-77-273-280-278-270-74-117(155(255)196-103)209-152(252)113(70-220)205-142(242)102(49-52-128(229)230)193-151(251)110(65-94-68-180-79-185-94)202-145(245)104(59-81(3)4)197-140(240)99(36-25-55-183-169(178)179)194-163(263)130(82(5)6)213-160(260)121(217-216-88(13)222)78-274-282-281-271-75-118(210-159(119)259)158(258)204-112(67-129(231)232)165(265)218-56-26-37-122(218)161(261)188-84(9)135(235)186-86(11)137(237)215-132(87(12)221)164(264)212-120/h14-22,28-33,39-46,68,79-87,97-123,130-132,217,220-221,223-224H,23-27,34-38,47-67,69-78H2,1-13H3,(H2,170,225)(H2,171,226)(H2,172,227)(H2,173,234)(H,180,185)(H,184,238)(H,186,235)(H,187,244)(H,188,261)(H,189,228)(H,190,253)(H,191,254)(H,192,241)(H,193,251)(H,194,263)(H,195,236)(H,196,255)(H,197,240)(H,198,239)(H,199,246)(H,200,256)(H,201,257)(H,202,245)(H,203,247)(H,204,258)(H,205,242)(H,206,249)(H,207,250)(H,208,248)(H,209,252)(H,210,259)(H,211,262)(H,212,264)(H,213,260)(H,214,243)(H,215,237)(H,216,222)(H,229,230)(H,231,232)(H4,174,175,181)(H4,176,177,182)(H4,178,179,183)/t84-,85-,86-,87+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,130-,131-,132-/m0/s1 MYQDHXIMPMJXBQ-MNQAAEEESA-N 50144871 CHEMBL428134 Melanocortin receptor 4 Mus musculus 29.8 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144871&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310103 104033896 CHEMBL428134 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820977 C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)NC(NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)78-48(29-37-13-6-3-7-14-37)61(96)76-45(17-10-26-73-68(70)71)59(94)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,96)(H,77,93)(H,78,98)(H,79,94)(H,80,97)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47-,48-,49-,50+,51-,52+,57?/m1/s1 BXPSHOXUOUAVOO-XLFZXRFMSA-N 50144874 CHEMBL440633::Tyr-c[Asp-Phe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 9200 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144874&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932909 104033899 CHEMBL440633 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820978 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.21 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820983 CC(C)C[C@@H]1NC(=O)[C@@H]2CSSSSC[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSSSSC[C@H](NNC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4c[nH]cn4)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N2)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSSSC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC3=O)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)NN(Cc3ccccc3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C(C)C)[C@@H](C)O InChI=1S/C176H251N55O48S16/c1-83(2)57-109-144(250)193-70-133(240)199-106(46-49-130(177)237)147(253)201-107(47-50-131(178)238)149(255)224-137(86(7)8)172(278)230-56-26-37-129(230)168(274)220-125-78-285-292-288-280-73-120(158(264)200-103(139(245)140(180)246)33-22-52-189-173(181)182)215-153(259)112(60-93-38-42-99(235)43-39-93)207-160(266)121-74-281-289-290-282-75-122(161(267)211-116(64-98-69-188-82-195-98)166(272)228-231(71-95-29-18-15-19-30-95)176(279)222-105(35-24-54-191-175(185)186)146(252)209-114(62-96-67-192-102-32-21-20-31-101(96)102)155(261)212-117(65-132(179)239)150(256)197-88(10)142(248)204-111(152(258)216-121)59-92-27-16-14-17-28-92)217-154(260)113(61-94-40-44-100(236)45-41-94)208-162(268)126-79-286-293-291-283-76-123(159(265)205-109)218-157(263)119(72-232)214-148(254)108(48-51-134(241)242)202-156(262)115(63-97-68-187-81-194-97)210-151(257)110(58-84(3)4)206-145(251)104(34-23-53-190-174(183)184)203-169(275)136(85(5)6)223-165(271)127(227-226-91(13)234)80-287-295-294-284-77-124(219-164(125)270)163(269)213-118(66-135(243)244)171(277)229-55-25-36-128(229)167(273)198-87(9)141(247)196-89(11)143(249)225-138(90(12)233)170(276)221-126/h14-21,27-32,38-45,67-69,81-90,103-129,136-138,192,227,232-233,235-236H,22-26,33-37,46-66,70-80H2,1-13H3,(H2,177,237)(H2,178,238)(H2,179,239)(H2,180,246)(H,187,194)(H,188,195)(H,193,250)(H,196,247)(H,197,256)(H,198,273)(H,199,240)(H,200,264)(H,201,253)(H,202,262)(H,203,275)(H,204,248)(H,205,265)(H,206,251)(H,207,266)(H,208,268)(H,209,252)(H,210,257)(H,211,267)(H,212,261)(H,213,269)(H,214,254)(H,215,259)(H,216,258)(H,217,260)(H,218,263)(H,219,270)(H,220,274)(H,221,276)(H,222,279)(H,223,271)(H,224,255)(H,225,249)(H,226,234)(H,228,272)(H,241,242)(H,243,244)(H4,181,182,189)(H4,183,184,190)(H4,185,186,191)/t87-,88-,89-,90+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,136-,137-,138-/m0/s1 VXPXNPZGHGRGER-GVUQCVNKSA-N 50144877 CHEMBL269274 Melanocortin receptor 4 Mus musculus 1.4 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144877&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310344 104033902 CHEMBL269274 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820984 CNC(=O)C[C@H]1NC(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)NCC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O)C(=O)NC(Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C52H68N14O15/c1-25-44(73)58-27(3)47(76)63-36(22-40(69)55-5)48(77)60-28(4)46(75)61-34(19-29-9-7-6-8-10-29)42(71)52(81)65-39(51(80)62-35(43(53)72)20-30-11-15-32(67)16-12-30)24-56-41(70)23-37(49(78)59-26(2)45(74)57-25)64-50(79)38(66-54)21-31-13-17-33(68)18-14-31/h6-18,25-28,34-39,66-68H,19-24,54H2,1-5H3,(H2,53,72)(H,55,69)(H,56,70)(H,57,74)(H,58,73)(H,59,78)(H,60,77)(H,61,75)(H,62,80)(H,63,76)(H,64,79)(H,65,81)/t25-,26+,27+,28+,34-,35?,36-,37+,38+,39?/m1/s1 YUHAAKMAZYVMDB-ROAFZXINSA-N 50144872 CHEMBL384224::Tyr-c[Asp-Ala-Ala-Ala-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144872&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310199 104033897 CHEMBL384224 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820985 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@@H](CC(=O)NC(NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NN[C@H]1Cc2ccc(O)cc2NC1=O InChI=1S/C73H85N21O17/c1-37-62(100)84-52(27-39-13-6-3-7-14-39)68(106)90-61(71(109)94-91-50(60(99)72(110)111)25-40-18-21-44(95)22-19-40)89-59(98)33-57(93-92-56-28-41-20-23-45(96)31-49(41)83-69(56)107)70(108)87-54(30-43-35-77-36-80-43)67(105)85-51(26-38-11-4-2-5-12-38)65(103)82-48(17-10-24-78-73(75)76)63(101)86-53(29-42-34-79-47-16-9-8-15-46(42)47)66(104)88-55(32-58(74)97)64(102)81-37/h2-9,11-16,18-23,31,34-37,48,50-57,61,79,91-93,95-96H,10,17,24-30,32-33H2,1H3,(H2,74,97)(H,77,80)(H,81,102)(H,82,103)(H,83,107)(H,84,100)(H,85,105)(H,86,101)(H,87,108)(H,88,104)(H,89,98)(H,90,106)(H,94,109)(H,110,111)(H4,75,76,78)/t37-,48+,50-,51-,52+,53-,54+,55+,56-,57+,61?/m0/s1 IURJLDFCJBKSNA-SMZVWYTNSA-N 50144880 CHEMBL406032::Tyr-c[Asp-His-Phe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 540 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144880&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932913 104033905 CHEMBL406032 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820986 C[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(=O)NC(NC(=O)C(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C68H80N18O17/c1-35-58(93)77-46(27-36-11-4-2-5-12-36)55(91)65(100)83-57(66(101)86-85-47(56(92)67(102)103)28-38-18-22-41(87)23-19-38)82-54(90)33-51(81-64(99)52(84-72)30-39-20-24-42(88)25-21-39)63(98)78-48(29-37-13-6-3-7-14-37)61(96)76-45(17-10-26-73-68(70)71)59(94)79-49(31-40-34-74-44-16-9-8-15-43(40)44)62(97)80-50(32-53(69)89)60(95)75-35/h2-9,11-16,18-25,34-35,45-52,57,74,84-85,87-88H,10,17,26-33,72H2,1H3,(H2,69,89)(H,75,95)(H,76,96)(H,77,93)(H,78,98)(H,79,94)(H,80,97)(H,81,99)(H,82,90)(H,83,100)(H,86,101)(H,102,103)(H4,70,71,73)/t35-,45+,46+,47-,48-,49-,50+,51-,52+,57?/m1/s1 BXPSHOXUOUAVOO-XLFZXRFMSA-N 50144874 CHEMBL440633::Tyr-c[Asp-Phe-Arg-Trp-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 4100 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144874&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932909 104033899 CHEMBL440633 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820989 CC(C)C[C@@H]1NC(=O)[C@@H]2CSSSSC[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSSSSC[C@H](NNC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4c[nH]cn4)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N2)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSSSC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC3=O)C(=O)N[C@@H](Cc3c[nH]cn3)C(=O)NN(Cc3ccccc3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C(C)C)[C@@H](C)O InChI=1S/C176H251N55O48S16/c1-83(2)57-109-144(250)193-70-133(240)199-106(46-49-130(177)237)147(253)201-107(47-50-131(178)238)149(255)224-137(86(7)8)172(278)230-56-26-37-129(230)168(274)220-125-78-285-292-288-280-73-120(158(264)200-103(139(245)140(180)246)33-22-52-189-173(181)182)215-153(259)112(60-93-38-42-99(235)43-39-93)207-160(266)121-74-281-289-290-282-75-122(161(267)211-116(64-98-69-188-82-195-98)166(272)228-231(71-95-29-18-15-19-30-95)176(279)222-105(35-24-54-191-175(185)186)146(252)209-114(62-96-67-192-102-32-21-20-31-101(96)102)155(261)212-117(65-132(179)239)150(256)197-88(10)142(248)204-111(152(258)216-121)59-92-27-16-14-17-28-92)217-154(260)113(61-94-40-44-100(236)45-41-94)208-162(268)126-79-286-293-291-283-76-123(159(265)205-109)218-157(263)119(72-232)214-148(254)108(48-51-134(241)242)202-156(262)115(63-97-68-187-81-194-97)210-151(257)110(58-84(3)4)206-145(251)104(34-23-53-190-174(183)184)203-169(275)136(85(5)6)223-165(271)127(227-226-91(13)234)80-287-295-294-284-77-124(219-164(125)270)163(269)213-118(66-135(243)244)171(277)229-55-25-36-128(229)167(273)198-87(9)141(247)196-89(11)143(249)225-138(90(12)233)170(276)221-126/h14-21,27-32,38-45,67-69,81-90,103-129,136-138,192,227,232-233,235-236H,22-26,33-37,46-66,70-80H2,1-13H3,(H2,177,237)(H2,178,238)(H2,179,239)(H2,180,246)(H,187,194)(H,188,195)(H,193,250)(H,196,247)(H,197,256)(H,198,273)(H,199,240)(H,200,264)(H,201,253)(H,202,262)(H,203,275)(H,204,248)(H,205,265)(H,206,251)(H,207,266)(H,208,268)(H,209,252)(H,210,257)(H,211,267)(H,212,261)(H,213,269)(H,214,254)(H,215,259)(H,216,258)(H,217,260)(H,218,263)(H,219,270)(H,220,274)(H,221,276)(H,222,279)(H,223,271)(H,224,255)(H,225,249)(H,226,234)(H,228,272)(H,241,242)(H,243,244)(H4,181,182,189)(H4,183,184,190)(H4,185,186,191)/t87-,88-,89-,90+,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,136-,137-,138-/m0/s1 VXPXNPZGHGRGER-GVUQCVNKSA-N 50144877 CHEMBL269274 Melanocortin receptor 4 Mus musculus 4.45 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144877&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310344 104033902 CHEMBL269274 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820404 C[C@@H](O)[C@H](NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O InChI=1S/C55H72N16O10/c1-31(72)46(47(57)74)71-50(77)39-19-10-11-21-61-45(73)27-44(67-48(75)37(56)23-32-13-4-2-5-14-32)54(81)70-43(26-35-29-60-30-64-35)53(80)68-41(24-33-15-6-3-7-16-33)51(78)66-40(20-12-22-62-55(58)59)49(76)69-42(52(79)65-39)25-34-28-63-38-18-9-8-17-36(34)38/h2-9,13-18,28-31,37,39-44,46,63,72H,10-12,19-27,56H2,1H3,(H2,57,74)(H,60,64)(H,61,73)(H,65,79)(H,66,78)(H,67,75)(H,68,80)(H,69,76)(H,70,81)(H,71,77)(H4,58,59,62)/t31-,37+,39-,40+,41-,42-,43+,44+,46+/m1/s1 OZQPRMAYOQICHP-LOBOJTKKSA-N 50141018 1N-(1-carbamoyl-2-hydroxypropyl)-7-[3-amino(imino)methylaminopropyl]-16-(1-amino-2-phenylethylcarboxamido)-10-benzyl-13-(1H-5-imidazolylmethyl)-4-(1H-3-indolylmethyl)-3,6,9,12,15,18-hexaoxo-2,5,8,11,14,19-hexaazacyclotricosane-1-carboxamide::CHEMBL414965 Melanocortin receptor 4 Mus musculus 0.380000 ChEMBL 10.1021/jm030452x 10.7270/Q2XP75PK 14998337 Han, G; Haskell-Luevano, C; Kendall, L; Bonner, G; Hadley, ME; Cone, RD; Hruby, VJ University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50141018 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50141018&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44285133 104030530 CHEMBL414965 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820410 C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37-,38-,39-,40+,41-,42+/m1/s1 HGUGDVPBNFFDAR-NVKXZJFQSA-N 50141023 1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino)methylaminopropyl]-6-(1-amino-2-phenylethylcarboxamido)-12-benzyl-9-(1H-5-imidazolylmethyl)-18-(1H-3-indolylmethyl)-7,10,13,16,19-pentaoxo-3,4-dithia-8,11,14,17,20-pentaazacycloicosane-1-carboxam::CHEMBL405087 Melanocortin receptor 4 Mus musculus 0.200000 ChEMBL 10.1021/jm030452x 10.7270/Q2XP75PK 14998337 Han, G; Haskell-Luevano, C; Kendall, L; Bonner, G; Hadley, ME; Cone, RD; Hruby, VJ University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50141023 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50141023&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44285237 104030535 CHEMBL405087 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820434 C[C@H](O)[C@@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O InChI=1S/C51H64ClN15O9S2/c1-27(68)42(43(54)69)67-50(76)41-25-78-77-24-40(65-44(70)34(53)18-28-8-3-2-4-9-28)49(75)64-39(21-32-23-57-26-60-32)48(74)62-37(19-29-13-15-31(52)16-14-29)46(72)61-36(12-7-17-58-51(55)56)45(71)63-38(47(73)66-41)20-30-22-59-35-11-6-5-10-33(30)35/h2-6,8-11,13-16,22-23,26-27,34,36-42,59,68H,7,12,17-21,24-25,53H2,1H3,(H2,54,69)(H,57,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,58)/t27-,34+,36-,37-,38+,39-,40-,41+,42+/m0/s1 WZAMLQNJEPHSTH-JMCLYXOWSA-N 50141027 1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino)methylaminopropyl]-6-(1-amino-2-phenylethylcarboxamido)-12-(4-chlorobenzyl)-9-(1H-5-imidazolylmethyl)-18-(1H-3-indolylmethyl)-7,10,13,16,19-pentaoxo-3,4-dithia-8,11,14,17,20-pentaazacycloicosane-::CHEMBL406842 Melanocortin receptor 4 Mus musculus 0.670000 ChEMBL 10.1021/jm030452x 10.7270/Q2XP75PK 14998337 Han, G; Haskell-Luevano, C; Kendall, L; Bonner, G; Hadley, ME; Cone, RD; Hruby, VJ University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50141027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50141027&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44285234 104030539 CHEMBL406842 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820445 C[C@@H](O)[C@H](NC(=O)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc1ccccc1)C(N)=O InChI=1S/C53H69N15O9S2/c1-29(69)42(44(55)70)67-51(77)43-53(2,3)79-78-27-41(66-45(71)35(54)21-30-13-6-4-7-14-30)50(76)65-40(24-33-26-58-28-61-33)48(74)63-38(22-31-15-8-5-9-16-31)47(73)62-37(19-12-20-59-52(56)57)46(72)64-39(49(75)68-43)23-32-25-60-36-18-11-10-17-34(32)36/h4-11,13-18,25-26,28-29,35,37-43,60,69H,12,19-24,27,54H2,1-3H3,(H2,55,70)(H,58,61)(H,62,73)(H,63,74)(H,64,72)(H,65,76)(H,66,71)(H,67,77)(H,68,75)(H4,56,57,59)/t29-,35-,37+,38-,39-,40-,41+,42+,43+/m1/s1 HJGHPWYMORIUAG-FFQQBTGJSA-N 50141019 CHEMBL411400::H-D-Phe-c[Cys-His-D-Phe-Arg-Trp-Pen]-Thr-NH2 Melanocortin receptor 4 Mus musculus 20 ChEMBL 10.1021/jm030452x 10.7270/Q2XP75PK 14998337 Han, G; Haskell-Luevano, C; Kendall, L; Bonner, G; Hadley, ME; Cone, RD; Hruby, VJ University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50141019 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50141019&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44285238 104030531 CHEMBL411400 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820446 C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(CCCN)CC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O InChI=1S/C50H63N13O9S2/c1-29(64)43(44(53)66)62-49(71)41-27-74-73-26-40(60-45(67)35(52)19-30-11-4-2-5-12-30)48(70)58-38(22-33-24-54-28-56-33)47(69)59-39(20-31-13-6-3-7-14-31)50(72)63(18-10-17-51)25-42(65)57-37(46(68)61-41)21-32-23-55-36-16-9-8-15-34(32)36/h2-9,11-16,23-24,28-29,35,37-41,43,55,64H,10,17-22,25-27,51-52H2,1H3,(H2,53,66)(H,54,56)(H,57,65)(H,58,70)(H,59,69)(H,60,67)(H,61,68)(H,62,71)/t29-,35-,37-,38+,39+,40+,41-,43+/m1/s1 DWRYDXIVRLJQFS-KWGBNJDESA-N 50141030 1N-(1-carbamoyl-2-hydroxypropyl)-6-(1-amino-2-phenylethylcarboxamido)-14-(3-aminopropyl)-12-benzyl-9-(1H-5-imidazolylmethyl)-18-(1H-3-indolylmethyl)-7,10,13,16,19-pentaoxo-3,4-dithia-8,11,14,17,20-pentaazacycloicosane-1-carboxamide::CHEMBL415200 Melanocortin receptor 4 Mus musculus 180 ChEMBL 10.1021/jm030452x 10.7270/Q2XP75PK 14998337 Han, G; Haskell-Luevano, C; Kendall, L; Bonner, G; Hadley, ME; Cone, RD; Hruby, VJ University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50141030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50141030&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44285388 104030542 CHEMBL415200 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820447 C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc(C)[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O InChI=1S/C52H67N15O9S2/c1-28(68)43(44(54)69)67-51(76)42-27-78-77-26-41(65-45(70)35(53)20-30-12-5-3-6-13-30)50(75)64-40(23-33-25-58-29(2)60-33)49(74)62-38(21-31-14-7-4-8-15-31)47(72)61-37(18-11-19-57-52(55)56)46(71)63-39(48(73)66-42)22-32-24-59-36-17-10-9-16-34(32)36/h3-10,12-17,24-25,28,35,37-43,59,68H,11,18-23,26-27,53H2,1-2H3,(H2,54,69)(H,58,60)(H,61,72)(H,62,74)(H,63,71)(H,64,75)(H,65,70)(H,66,73)(H,67,76)(H4,55,56,57)/t28-,35+,37+,38-,39-,40+,41+,42-,43+/m1/s1 HEOQNUAQOHARQX-UCJIMMPYSA-N 50141029 1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino)methylaminopropyl]-6-(1-amino-2-phenylethylcarboxamido)-12-benzyl-18-(1H-3-indolylmethyl)-9-(2-methyl-1H-5-imidazolylmethyl)-7,10,13,16,19-pentaoxo-3,4-dithia-8,11,14,17,20-pentaazacycloicosane-1::CHEMBL411378 Melanocortin receptor 4 Mus musculus 8.9 ChEMBL 10.1021/jm030452x 10.7270/Q2XP75PK 14998337 Han, G; Haskell-Luevano, C; Kendall, L; Bonner, G; Hadley, ME; Cone, RD; Hruby, VJ University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50141029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50141029&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44285102 104030541 CHEMBL411378 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820458 C[C@@H](O)[C@H](NC(=O)[C@H]1CCSSC[C@H](NC(=O)[C@@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O InChI=1S/C52H67N15O9S2/c1-29(68)43(44(54)69)67-47(72)38-18-20-77-78-27-42(66-45(70)35(53)21-30-11-4-2-5-12-30)51(76)65-41(24-33-26-57-28-60-33)50(75)63-39(22-31-13-6-3-7-14-31)48(73)61-37(17-10-19-58-52(55)56)46(71)64-40(49(74)62-38)23-32-25-59-36-16-9-8-15-34(32)36/h2-9,11-16,25-26,28-29,35,37-43,59,68H,10,17-24,27,53H2,1H3,(H2,54,69)(H,57,60)(H,61,73)(H,62,74)(H,63,75)(H,64,71)(H,65,76)(H,66,70)(H,67,72)(H4,55,56,58)/t29-,35+,37+,38-,39-,40-,41+,42+,43+/m1/s1 BGHGOKPNEQCGCY-RSTNRAGRSA-N 50141028 1N-(1-carbamoyl-2-hydroxypropyl)-16-[3-amino(imino)methylaminopropyl]-7-(1-amino-2-phenylethylcarboxamido)-13-benzyl-10-(1H-5-imidazolylmethyl)-19-(1H-3-indolylmethyl)-8,11,14,17,20-pentaoxo-4,5-dithia-9,12,15,18,21-pentaazacyclohenicosane-1-carb::CHEMBL406891 Melanocortin receptor 4 Mus musculus 51 ChEMBL 10.1021/jm030452x 10.7270/Q2XP75PK 14998337 Han, G; Haskell-Luevano, C; Kendall, L; Bonner, G; Hadley, ME; Cone, RD; Hruby, VJ University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50141028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50141028&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44285432 104030540 CHEMBL406891 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50820460 C[C@@H](O)[C@H](NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1)C(N)=O InChI=1S/C51H65N15O9S2/c1-28(67)42(43(53)68)66-50(75)41-26-77-76-25-40(64-44(69)34(52)19-29-11-4-2-5-12-29)49(74)63-39(22-32-24-56-27-59-32)48(73)61-37(20-30-13-6-3-7-14-30)46(71)60-36(17-10-18-57-51(54)55)45(70)62-38(47(72)65-41)21-31-23-58-35-16-9-8-15-33(31)35/h2-9,11-16,23-24,27-28,34,36-42,58,67H,10,17-22,25-26,52H2,1H3,(H2,53,68)(H,56,59)(H,60,71)(H,61,73)(H,62,70)(H,63,74)(H,64,69)(H,65,72)(H,66,75)(H4,54,55,57)/t28-,34-,36+,37+,38-,39+,40+,41-,42+/m1/s1 HGUGDVPBNFFDAR-NVTBXEIASA-N 50141026 1N-(1-carbamoyl-2-hydroxypropyl)-15-[3-amino(imino)methylaminopropyl]-6-(1-amino-2-phenylethylcarboxamido)-12-benzyl-9-(1H-5-imidazolylmethyl)-18-(1H-3-indolylmethyl)-7,10,13,16,19-pentaoxo-3,4-dithia-8,11,14,17,20-pentaazacycloicosane-1-carboxam::CHEMBL410404 Melanocortin receptor 4 Mus musculus 1.4 ChEMBL 10.1021/jm030452x 10.7270/Q2XP75PK 14998337 Han, G; Haskell-Luevano, C; Kendall, L; Bonner, G; Hadley, ME; Cone, RD; Hruby, VJ University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50141026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50141026&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44285261 104030538 CHEMBL410404 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50844563 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.13 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50844572 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)C1CC(O)=O)C(N)=O InChI=1S/C53H73N15O11/c1-3-4-16-38(62-30(2)69)48(75)65-40-26-44(70)58-20-11-10-18-37(46(54)73)63-51(78)42(23-32-27-60-36-17-9-8-15-34(32)36)68-49(76)39(19-12-21-59-53(55)56)64-50(77)41(22-31-13-6-5-7-14-31)67-52(79)43(24-33-28-57-29-61-33)66-47(74)35(40)25-45(71)72/h5-9,13-15,17,27-29,35,37-43,60H,3-4,10-12,16,18-26H2,1-2H3,(H2,54,73)(H,57,61)(H,58,70)(H,62,69)(H,63,78)(H,64,77)(H,65,75)(H,66,74)(H,67,79)(H,68,76)(H,71,72)(H4,55,56,59)/t35?,37-,38-,39-,40-,41+,42-,43-/m0/s1 BOKVGYPHNIKRLQ-DEHKQVQUSA-N 50158406 Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2::CHEMBL224277 Melanocortin receptor 4 Mus musculus 0.04 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50158406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50158406&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44421514 104045160 CHEMBL224277 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50844584 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 1.89 ChEMBL 10.1021/jm0492756 10.7270/Q27D2VZK 15615519 Joseph, CG; Wang, XS; Scott, JW; Bauzo, RM; Xiang, Z; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861066 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 2.56 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861067 CCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O InChI=1S/C19H20N2O2/c1-2-12-21-17-11-7-6-10-15(17)18(22)20-16(19(21)23)13-14-8-4-3-5-9-14/h3-11,16H,2,12-13H2,1H3,(H,20,22) SWJAFTBYNQPGLT-UHFFFAOYSA-N 50374122 CHEMBL269837 Melanocortin receptor 4 Mus musculus 35000 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374122&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44456958 160853223 CHEMBL269837 ZINC29133163 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861068 O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2-c2ccccc2)c2ccccc12 InChI=1S/C29H24N2O2/c32-28-25-17-9-10-18-27(25)31(29(33)26(30-28)19-21-11-3-1-4-12-21)20-23-15-7-8-16-24(23)22-13-5-2-6-14-22/h1-18,26H,19-20H2,(H,30,32) RONAYXZXQCHUAB-UHFFFAOYSA-N 50374123 CHEMBL273044 Melanocortin receptor 4 Mus musculus 1970 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374123&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44456957 160853224 CHEMBL273044 ZINC29133159 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861069 O=C1NC(Cc2ccccc2)C(=O)N(Cc2ccccc2)c2ccccc12 InChI=1S/C23H20N2O2/c26-22-19-13-7-8-14-21(19)25(16-18-11-5-2-6-12-18)23(27)20(24-22)15-17-9-3-1-4-10-17/h1-14,20H,15-16H2,(H,24,26) NXEAZDQUXPQNGE-UHFFFAOYSA-N 50374117 CHEMBL406651 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374117&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44457036 160853218 CHEMBL406651 ZINC29133485 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861070 CCCCN1c2ccccc2C(=O)NC(Cc2ccccc2)C1=O InChI=1S/C20H22N2O2/c1-2-3-13-22-18-12-8-7-11-16(18)19(23)21-17(20(22)24)14-15-9-5-4-6-10-15/h4-12,17H,2-3,13-14H2,1H3,(H,21,23) XQZLCAHTPXINJY-UHFFFAOYSA-N 50374118 CHEMBL270689 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374118&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44456956 160853219 CHEMBL270689 ZINC29133153 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861071 Cc1cccc2c1N(Cc1ccccc1)C(=O)C(Cc1cn(Cc3ccccc3)c3ccccc13)NC2=O InChI=1S/C33H29N3O2/c1-23-11-10-17-28-31(23)36(21-25-14-6-3-7-15-25)33(38)29(34-32(28)37)19-26-22-35(20-24-12-4-2-5-13-24)30-18-9-8-16-27(26)30/h2-18,22,29H,19-21H2,1H3,(H,34,37) AZKFUYPRWRRXSX-UHFFFAOYSA-N 50374119 CHEMBL410435 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374119&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44457022 160853220 CHEMBL410435 ZINC29133414 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861072 O=C1NC(Cc2c[nH]c3ccccc23)C(=O)N(Cc2ccccc2)c2ccccc12 InChI=1S/C25H21N3O2/c29-24-20-11-5-7-13-23(20)28(16-17-8-2-1-3-9-17)25(30)22(27-24)14-18-15-26-21-12-6-4-10-19(18)21/h1-13,15,22,26H,14,16H2,(H,27,29) YEQKJKZQLXZDFA-UHFFFAOYSA-N 50374120 CHEMBL272843 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374120&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44457035 160853221 CHEMBL272843 ZINC29133481 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861073 NC(N)=NCCCC1NC(=O)c2ccccc2N(Cc2ccccc2)C1=O InChI=1S/C20H23N5O2/c21-20(22)23-12-6-10-16-19(27)25(13-14-7-2-1-3-8-14)17-11-5-4-9-15(17)18(26)24-16/h1-5,7-9,11,16H,6,10,12-13H2,(H,24,26)(H4,21,22,23) ISYKEWZFNMQKFW-UHFFFAOYSA-N 50374121 CHEMBL272662 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374121&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44457034 160853222 CHEMBL272662 ZINC29133477 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861083 NCCCCC1NC(=O)c2ccc(Cl)cc2N(Cc2ccccc2)C1=O InChI=1S/C20H22ClN3O2/c21-15-9-10-16-18(12-15)24(13-14-6-2-1-3-7-14)20(26)17(23-19(16)25)8-4-5-11-22/h1-3,6-7,9-10,12,17H,4-5,8,11,13,22H2,(H,23,25) YJDGJKULBWAHHK-UHFFFAOYSA-N 50374116 CHEMBL270270 Melanocortin receptor 4 Mus musculus 240 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374116&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 24882615 160853217 CHEMBL270270 ZINC29133331 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50861084 Clc1ccc2c(c1)N(Cc1ccc3ccccc3c1)C(=O)C(Cc1c[nH]c3ccccc13)NC2=O InChI=1S/C29H22ClN3O2/c30-22-11-12-24-27(15-22)33(17-18-9-10-19-5-1-2-6-20(19)13-18)29(35)26(32-28(24)34)14-21-16-31-25-8-4-3-7-23(21)25/h1-13,15-16,26,31H,14,17H2,(H,32,34) KYBZSOAEPBZBSJ-UHFFFAOYSA-N 50374114 CHEMBL272437 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/jm701303z 10.7270/Q2KH0P61 18271518 Joseph, CG; Wilson, KR; Wood, MS; Sorenson, NB; Phan, DV; Xiang, Z; Witek, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374114&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44456983 160853215 CHEMBL272437 ZINC29133243 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50862726 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.097 ChEMBL 10.1021/jm701093y 10.7270/Q29W0GC3 18220330 Hess, S; Linde, Y; Ovadia, O; Safrai, E; Shalev, DE; Swed, A; Halbfinger, E; Lapidot, T; Winkler, I; Gabinet, Y; Faier, A; Yarden, D; Xiang, Z; Portillo, FP; Haskell-Luevano, C; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50862727 NC(=O)CN1CCNC(=O)c2ccccc2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C47H53N11O7/c48-40(59)28-58-23-22-51-41(60)33-17-7-8-18-34(33)42(61)55-37(24-29-12-3-1-4-13-29)45(64)56-38(25-30-14-5-2-6-15-30)44(63)54-36(20-11-21-52-47(49)50)43(62)57-39(46(58)65)26-31-27-53-35-19-10-9-16-32(31)35/h1-10,12-19,27,36-39,53H,11,20-26,28H2,(H2,48,59)(H,51,60)(H,54,63)(H,55,61)(H,56,64)(H,57,62)(H4,49,50,52)/t36-,37-,38+,39-/m0/s1 WUPNBGOBZWSAPY-RUPCYPOASA-N 50374670 CHEMBL270923 Melanocortin receptor 4 Mus musculus 150 ChEMBL 10.1021/jm701093y 10.7270/Q29W0GC3 18220330 Hess, S; Linde, Y; Ovadia, O; Safrai, E; Shalev, DE; Swed, A; Halbfinger, E; Lapidot, T; Winkler, I; Gabinet, Y; Faier, A; Yarden, D; Xiang, Z; Portillo, FP; Haskell-Luevano, C; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374670&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44457043 160853760 CHEMBL270923 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50862734 NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C43H53N11O7/c44-36(55)26-54-21-20-47-37(56)17-18-38(57)50-33(22-27-10-3-1-4-11-27)40(59)52-34(23-28-12-5-2-6-13-28)41(60)51-32(16-9-19-48-43(45)46)39(58)53-35(42(54)61)24-29-25-49-31-15-8-7-14-30(29)31/h1-8,10-15,25,32-35,49H,9,16-24,26H2,(H2,44,55)(H,47,56)(H,50,57)(H,51,60)(H,52,59)(H,53,58)(H4,45,46,48)/t32-,33-,34+,35-/m0/s1 SDQCGYICPSEQGF-KMSCUOMXSA-N 50374673 CHEMBL408398 Melanocortin receptor 4 Mus musculus 4 ChEMBL 10.1021/jm701093y 10.7270/Q29W0GC3 18220330 Hess, S; Linde, Y; Ovadia, O; Safrai, E; Shalev, DE; Swed, A; Halbfinger, E; Lapidot, T; Winkler, I; Gabinet, Y; Faier, A; Yarden, D; Xiang, Z; Portillo, FP; Haskell-Luevano, C; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374673&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 15602927 160853763 CHEMBL408398 ZINC95543596 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50862743 NC(=O)CN1CCNC(=O)CCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C44H55N11O7/c45-37(56)27-55-22-21-48-38(57)18-9-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-10-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 PEATXQQSUKEHHE-KFIZHRIMSA-N 50374669 CHEMBL406985 Melanocortin receptor 4 Mus musculus 18 ChEMBL 10.1021/jm701093y 10.7270/Q29W0GC3 18220330 Hess, S; Linde, Y; Ovadia, O; Safrai, E; Shalev, DE; Swed, A; Halbfinger, E; Lapidot, T; Winkler, I; Gabinet, Y; Faier, A; Yarden, D; Xiang, Z; Portillo, FP; Haskell-Luevano, C; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374669&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44456964 160853759 CHEMBL406985 ZINC95613518 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50862744 NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C44H55N11O7/c45-37(56)27-55-22-10-21-48-38(57)18-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-9-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 OHZACAASEFWFDZ-KFIZHRIMSA-N 50374671 CHEMBL272660 Melanocortin receptor 4 Mus musculus 4 ChEMBL 10.1021/jm701093y 10.7270/Q29W0GC3 18220330 Hess, S; Linde, Y; Ovadia, O; Safrai, E; Shalev, DE; Swed, A; Halbfinger, E; Lapidot, T; Winkler, I; Gabinet, Y; Faier, A; Yarden, D; Xiang, Z; Portillo, FP; Haskell-Luevano, C; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374671&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 15603023 160853761 CHEMBL272660 ZINC95608091 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50862745 NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O InChI=1S/C46H59N11O7/c47-39(58)29-57-24-12-23-50-40(59)20-9-10-21-41(60)53-36(25-30-13-3-1-4-14-30)43(62)55-37(26-31-15-5-2-6-16-31)44(63)54-35(19-11-22-51-46(48)49)42(61)56-38(45(57)64)27-32-28-52-34-18-8-7-17-33(32)34/h1-8,13-18,28,35-38,52H,9-12,19-27,29H2,(H2,47,58)(H,50,59)(H,53,60)(H,54,63)(H,55,62)(H,56,61)(H4,48,49,51)/t35-,36-,37+,38-/m0/s1 FTHTUSUQUUNCDD-DYLMPHRMSA-N 50374672 CHEMBL271586 Melanocortin receptor 4 Mus musculus 5 ChEMBL 10.1021/jm701093y 10.7270/Q29W0GC3 18220330 Hess, S; Linde, Y; Ovadia, O; Safrai, E; Shalev, DE; Swed, A; Halbfinger, E; Lapidot, T; Winkler, I; Gabinet, Y; Faier, A; Yarden, D; Xiang, Z; Portillo, FP; Haskell-Luevano, C; Gilon, C; Hoffman, A The Hebrew University of Jerusalem http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50374672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50374672&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44457067 160853762 CHEMBL271586 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877145 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H42IN11O5/c1-19(47)43-29(15-23-17-39-18-42-23)33(51)46-28(13-20-8-10-22(35)11-9-20)32(50)44-26(7-4-12-40-34(37)38)31(49)45-27(30(36)48)14-21-16-41-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,41H,4,7,12-15H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,37,38,40)/t26-,27-,28+,29-/m0/s1 OBADRSUMIBIHEX-FKWFRFQNSA-N 50115373 2-[2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-(4-iodo-phenyl)-propionylamino]-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe(pI)-Arg-Trp-NH2::CHEMBL322610 Melanocortin receptor 4 Mus musculus 3.94 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115373 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115373&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9875763 104009350 CHEMBL322610 ZINC95610762 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877146 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Br)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H42BrN11O5/c1-19(47)43-29(15-23-17-39-18-42-23)33(51)46-28(13-20-8-10-22(35)11-9-20)32(50)44-26(7-4-12-40-34(37)38)31(49)45-27(30(36)48)14-21-16-41-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,41H,4,7,12-15H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,37,38,40)/t26-,27-,28+,29-/m0/s1 UDLFTFKLQRVSSE-FKWFRFQNSA-N 50252900 Ac-His-DPhe(pBr)-Arg-Trp-NH2::CHEMBL502093 Melanocortin receptor 4 Mus musculus 1.07 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108216 104105611 CHEMBL502093 ZINC95615940 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877147 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H42ClN11O5/c1-19(47)43-29(15-23-17-39-18-42-23)33(51)46-28(13-20-8-10-22(35)11-9-20)32(50)44-26(7-4-12-40-34(37)38)31(49)45-27(30(36)48)14-21-16-41-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,41H,4,7,12-15H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,37,38,40)/t26-,27-,28+,29-/m0/s1 ZUBCUEXAMNVTMP-FKWFRFQNSA-N 50252899 Ac-His-DPhe(pCl)-Arg-Trp-NH2::CHEMBL491870 Melanocortin receptor 4 Mus musculus 0.4 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252899&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108215 104105610 CHEMBL491870 ZINC49878600 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877148 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H42FN11O5/c1-19(47)43-29(15-23-17-39-18-42-23)33(51)46-28(13-20-8-10-22(35)11-9-20)32(50)44-26(7-4-12-40-34(37)38)31(49)45-27(30(36)48)14-21-16-41-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,41H,4,7,12-15H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,37,38,40)/t26-,27-,28+,29-/m0/s1 PWNJSQCLUARPLM-FKWFRFQNSA-N 50252898 Ac-His-DPhe(pF)-Arg-Trp-NH2::CHEMBL444219 Melanocortin receptor 4 Mus musculus 0.45 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252898&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108143 104105609 CHEMBL444219 ZINC49823135 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877149 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(cc1)[N+]([O-])=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H42N12O7/c1-19(47)42-29(15-22-17-38-18-41-22)33(51)45-28(13-20-8-10-23(11-9-20)46(52)53)32(50)43-26(7-4-12-39-34(36)37)31(49)44-27(30(35)48)14-21-16-40-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,40H,4,7,12-15H2,1H3,(H2,35,48)(H,38,41)(H,42,47)(H,43,50)(H,44,49)(H,45,51)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 KCIDBIZAMUCOIJ-FKWFRFQNSA-N 50252897 Ac-His-DPhe(pNO2)-Arg-Trp-NH2::CHEMBL451423 Melanocortin receptor 4 Mus musculus 13 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252897&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108142 104105608 CHEMBL451423 ZINC49833180 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877150 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(cc1)C#N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H42N12O5/c1-20(48)44-30(15-24-18-40-19-43-24)34(52)47-29(13-21-8-10-22(16-36)11-9-21)33(51)45-27(7-4-12-41-35(38)39)32(50)46-28(31(37)49)14-23-17-42-26-6-3-2-5-25(23)26/h2-3,5-6,8-11,17-19,27-30,42H,4,7,12-15H2,1H3,(H2,37,49)(H,40,43)(H,44,48)(H,45,51)(H,46,50)(H,47,52)(H4,38,39,41)/t27-,28-,29+,30-/m0/s1 DBWQPEKZJYCIEE-ZXYZSCNASA-N 50252896 Ac-His-DPhe(pCN)-Arg-Trp-NH2::CHEMBL448536 Melanocortin receptor 4 Mus musculus 2.84 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252896&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108141 104105607 CHEMBL448536 ZINC49833573 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877151 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cc2ccccc2)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C41H49N11O5/c1-25(53)49-36(21-30-23-45-24-48-30)40(57)52-35(19-28-15-13-27(14-16-28)18-26-8-3-2-4-9-26)39(56)50-33(12-7-17-46-41(43)44)38(55)51-34(37(42)54)20-29-22-47-32-11-6-5-10-31(29)32/h2-6,8-11,13-16,22-24,33-36,47H,7,12,17-21H2,1H3,(H2,42,54)(H,45,48)(H,49,53)(H,50,56)(H,51,55)(H,52,57)(H4,43,44,46)/t33-,34-,35+,36-/m0/s1 IAXQJICNQNNYCU-KFIZHRIMSA-N 50252895 Ac-His-DPhe(pBz)-Arg-Trp-NH2::CHEMBL455826 Melanocortin receptor 4 Mus musculus 63.8 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252895&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108140 104105606 CHEMBL455826 ZINC95615256 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877152 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C38H51N11O5/c1-22(50)46-32(18-26-20-42-21-45-26)36(54)49-31(16-23-11-13-25(14-12-23)38(2,3)4)35(53)47-29(10-7-15-43-37(40)41)34(52)48-30(33(39)51)17-24-19-44-28-9-6-5-8-27(24)28/h5-6,8-9,11-14,19-21,29-32,44H,7,10,15-18H2,1-4H3,(H2,39,51)(H,42,45)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,40,41,43)/t29-,30-,31+,32-/m0/s1 MMUWWLSBKXUHNW-IHZBLBIESA-N 50252894 Ac-His-DPhe(pt-Bu)-Arg-Trp-NH2::CHEMBL488355 Melanocortin receptor 4 Mus musculus 4360 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252894&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108087 104105605 CHEMBL488355 ZINC49872458 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877153 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(C)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H45N11O5/c1-20-9-11-22(12-10-20)14-29(46-34(51)30(43-21(2)47)16-24-18-39-19-42-24)33(50)44-27(8-5-13-40-35(37)38)32(49)45-28(31(36)48)15-23-17-41-26-7-4-3-6-25(23)26/h3-4,6-7,9-12,17-19,27-30,41H,5,8,13-16H2,1-2H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,37,38,40)/t27-,28-,29+,30-/m0/s1 NBONRIOTXHNHPH-ZXYZSCNASA-N 50252893 Ac-His-DPhe(pCH3)-Arg-Trp-NH2::CHEMBL503449 Melanocortin receptor 4 Mus musculus 5.65 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252893&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108086 104105604 CHEMBL503449 ZINC49889438 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877154 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(N)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H44N12O5/c1-19(47)43-29(15-23-17-39-18-42-23)33(51)46-28(13-20-8-10-22(35)11-9-20)32(50)44-26(7-4-12-40-34(37)38)31(49)45-27(30(36)48)14-21-16-41-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,41H,4,7,12-15,35H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,37,38,40)/t26-,27-,28+,29-/m0/s1 JRFFLTFJJPSALV-FKWFRFQNSA-N 50252892 Ac-His-DPhe(pNH2)-Arg-Trp-NH2::CHEMBL500516 Melanocortin receptor 4 Mus musculus 220 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252892&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108085 104105603 CHEMBL500516 ZINC49888862 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877155 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O6/c1-19(46)42-29(15-22-17-38-18-41-22)33(51)45-28(13-20-8-10-23(47)11-9-20)32(50)43-26(7-4-12-39-34(36)37)31(49)44-27(30(35)48)14-21-16-40-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,40,47H,4,7,12-15H2,1H3,(H2,35,48)(H,38,41)(H,42,46)(H,43,50)(H,44,49)(H,45,51)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 FGCBZBMPOFJXID-FKWFRFQNSA-N 50115366 2-[2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DTyr-Arg-Trp-NH2::CHEMBL105113 Melanocortin receptor 4 Mus musculus 390 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50115366 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50115366&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11039787 104009343 CHEMBL105113 ZINC26828757 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877156 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 2.28 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877157 CC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C38H45N11O5/c1-22(50)46-33(18-27-20-42-21-45-27)37(54)49-32(16-23-12-13-24-7-2-3-8-25(24)15-23)36(53)47-30(11-6-14-43-38(40)41)35(52)48-31(34(39)51)17-26-19-44-29-10-5-4-9-28(26)29/h2-5,7-10,12-13,15,19-21,30-33,44H,6,11,14,16-18H2,1H3,(H2,39,51)(H,42,45)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,40,41,43)/t30-,31-,32-,33+/m0/s1 OHBCPCNJWIQQPW-ZWDYZTTJSA-N 50252902 Ac-His-DNal(2)-Arg-Trp-NH2::CHEMBL454736 Melanocortin receptor 4 Mus musculus 19 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252902&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44568851 104105613 CHEMBL454736 ZINC49841297 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877192 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.12 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877193 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1cccc(Cl)c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H42ClN11O5/c1-19(47)43-29(15-23-17-39-18-42-23)33(51)46-28(13-20-6-4-7-22(35)12-20)32(50)44-26(10-5-11-40-34(37)38)31(49)45-27(30(36)48)14-21-16-41-25-9-3-2-8-24(21)25/h2-4,6-9,12,16-18,26-29,41H,5,10-11,13-15H2,1H3,(H2,36,48)(H,39,42)(H,43,47)(H,44,50)(H,45,49)(H,46,51)(H4,37,38,40)/t26-,27-,28+,29-/m0/s1 UKEQUTYGNFBBKH-FKWFRFQNSA-N 50252904 Ac-His-DPhe(m-Cl)-Arg-Trp-NH2::CHEMBL510687 Melanocortin receptor 4 Mus musculus 8.64 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252904&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108285 104105615 CHEMBL510687 ZINC49899387 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877194 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H41Cl2N11O5/c1-18(48)44-29(14-21-16-40-17-43-21)33(52)47-28(12-19-8-9-23(35)24(36)11-19)32(51)45-26(7-4-10-41-34(38)39)31(50)46-27(30(37)49)13-20-15-42-25-6-3-2-5-22(20)25/h2-3,5-6,8-9,11,15-17,26-29,42H,4,7,10,12-14H2,1H3,(H2,37,49)(H,40,43)(H,44,48)(H,45,51)(H,46,50)(H,47,52)(H4,38,39,41)/t26-,27-,28+,29-/m0/s1 ULVZZVUTBBXNBL-FKWFRFQNSA-N 50252903 Ac-His-DPhe(3,4-diCl)-Arg-Trp-NH2::CHEMBL501394 Melanocortin receptor 4 Mus musculus 3.4 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252903&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108218 104105614 CHEMBL501394 ZINC95615642 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50877195 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(cc1)C(F)(F)F)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C35H42F3N11O5/c1-19(50)46-29(15-23-17-42-18-45-23)33(54)49-28(13-20-8-10-22(11-9-20)35(36,37)38)32(53)47-26(7-4-12-43-34(40)41)31(52)48-27(30(39)51)14-21-16-44-25-6-3-2-5-24(21)25/h2-3,5-6,8-11,16-18,26-29,44H,4,7,12-15H2,1H3,(H2,39,51)(H,42,45)(H,46,50)(H,47,53)(H,48,52)(H,49,54)(H4,40,41,43)/t26-,27-,28+,29-/m0/s1 OBZQTNACJLTWOC-FKWFRFQNSA-N 50252901 Ac-His-DPhe(pCF3)-Arg-Trp-NH2::CHEMBL501679 Melanocortin receptor 4 Mus musculus 12.8 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252901&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 25108217 104105612 CHEMBL501679 ZINC95615798 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904577 NC(N)=NCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cc[nH]c1)NC(=O)CCCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C43H52N10O5/c44-39(55)35(25-31-27-49-33-17-8-7-16-32(31)33)52-40(56)34(18-10-21-48-43(45)46)51-42(58)37(23-29-13-5-2-6-14-29)53-41(57)36(24-30-20-22-47-26-30)50-38(54)19-9-15-28-11-3-1-4-12-28/h1-8,11-14,16-17,20,22,26-27,34-37,47,49H,9-10,15,18-19,21,23-25H2,(H2,44,55)(H,50,54)(H,51,58)(H,52,56)(H,53,57)(H4,45,46,48)/t34-,35+,36-,37+/m0/s1 PQSNGDOXBHHSOR-TWHRXLCVSA-N 50301155 CHEMBL569693::Ph(CH2)3CO-His-D-Phe-Arg-Trp-NH2 Melanocortin receptor 4 Mus musculus 0.54 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301155&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91934137 104155516 CHEMBL569693 ZINC95536681 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904578 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCCc1ccccc1)C(N)=O InChI=1S/C31H41N9O4/c32-28(42)24(14-8-16-36-31(33)34)39-29(43)25(17-22-11-5-2-6-12-22)40-30(44)26(18-23-19-35-20-37-23)38-27(41)15-7-13-21-9-3-1-4-10-21/h1-6,9-12,19-20,24-26H,7-8,13-18H2,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/t24-,25-,26+/m1/s1 PZZOHVGUHARWRP-CYXNTTPDSA-N 50301156 CHEMBL569694::Ph(CH2)3CO-His-D-Phe-Arg-NH2 Melanocortin receptor 4 Mus musculus 15140 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301156 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301156&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487404 104155517 CHEMBL569694 ZINC49680044 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904579 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccccc1)C(N)=O InChI=1S/C30H37N9O4/c31-27(41)23(12-7-15-35-30(32)33)38-28(42)24(16-21-10-5-2-6-11-21)39-29(43)25(17-22-18-34-19-36-22)37-26(40)14-13-20-8-3-1-4-9-20/h1-6,8-11,13-14,18-19,23-25H,7,12,15-17H2,(H2,31,41)(H,34,36)(H,37,40)(H,38,42)(H,39,43)(H4,32,33,35)/t23-,24-,25+/m1/s1 ZCUHKWDCXXFSBL-SDHSZQHLSA-N 50301125 (S)-2-((R)-2-((S)-2-cinnamamido-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL569695 Melanocortin receptor 4 Mus musculus 52950 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301125&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487405 104155486 CHEMBL569695 ZINC49680048 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904580 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccccc1F)C(N)=O InChI=1S/C30H36FN9O4/c31-22-10-5-4-9-20(22)12-13-26(41)38-25(16-21-17-35-18-37-21)29(44)40-24(15-19-7-2-1-3-8-19)28(43)39-23(27(32)42)11-6-14-36-30(33)34/h1-5,7-10,12-13,17-18,23-25H,6,11,14-16H2,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/t23-,24-,25+/m1/s1 TUKHJSCGQURWQQ-SDHSZQHLSA-N 50301126 (S)-2-((R)-2-((S)-2-(3-(2-fluorophenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL566150 Melanocortin receptor 4 Mus musculus 14700 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301126&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487406 104155487 CHEMBL566150 ZINC49678015 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904581 COc1ccccc1C=CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCN=C(N)N)C(N)=O InChI=1S/C31H39N9O5/c1-45-26-12-6-5-10-21(26)13-14-27(41)38-25(17-22-18-35-19-37-22)30(44)40-24(16-20-8-3-2-4-9-20)29(43)39-23(28(32)42)11-7-15-36-31(33)34/h2-6,8-10,12-14,18-19,23-25H,7,11,15-17H2,1H3,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/t23-,24-,25+/m1/s1 POHSNDLUDBIGIE-SDHSZQHLSA-N 50301127 (S)-2-((R)-2-((S)-3-(1H-imidazol-5-yl)-2-(3-(2-methoxyphenyl)acrylamido)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL566545 Melanocortin receptor 4 Mus musculus 13700 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301127&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487407 104155488 CHEMBL566545 ZINC49678193 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904582 COc1ccc(C=CC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCN=C(N)N)C(N)=O)cc1 InChI=1S/C31H39N9O5/c1-45-23-12-9-20(10-13-23)11-14-27(41)38-26(17-22-18-35-19-37-22)30(44)40-25(16-21-6-3-2-4-7-21)29(43)39-24(28(32)42)8-5-15-36-31(33)34/h2-4,6-7,9-14,18-19,24-26H,5,8,15-17H2,1H3,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/t24-,25-,26+/m1/s1 JYNLYZMGADFMLF-CYXNTTPDSA-N 50301128 (R)-2-((R)-2-((S)-3-(1H-imidazol-5-yl)-2-(3-(4-methoxyphenyl)acrylamido)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL565927 Melanocortin receptor 4 Mus musculus 60400 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301128&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487408 104155489 CHEMBL565927 ZINC49677817 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904583 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1cccc(Cl)c1)C(N)=O InChI=1S/C30H36ClN9O4/c31-21-9-4-8-20(14-21)11-12-26(41)38-25(16-22-17-35-18-37-22)29(44)40-24(15-19-6-2-1-3-7-19)28(43)39-23(27(32)42)10-5-13-36-30(33)34/h1-4,6-9,11-12,14,17-18,23-25H,5,10,13,15-16H2,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/t23-,24-,25+/m1/s1 SZZWCXOBVKSYFY-SDHSZQHLSA-N 50301129 (S)-2-((R)-2-((S)-2-(3-(3-chlorophenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL566162 Melanocortin receptor 4 Mus musculus 4010 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301129&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487409 104155490 CHEMBL566162 ZINC49678265 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904584 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1cccc(c1)C(F)(F)F)C(N)=O InChI=1S/C31H36F3N9O4/c32-31(33,34)21-9-4-8-20(14-21)11-12-26(44)41-25(16-22-17-38-18-40-22)29(47)43-24(15-19-6-2-1-3-7-19)28(46)42-23(27(35)45)10-5-13-39-30(36)37/h1-4,6-9,11-12,14,17-18,23-25H,5,10,13,15-16H2,(H2,35,45)(H,38,40)(H,41,44)(H,42,46)(H,43,47)(H4,36,37,39)/t23-,24-,25+/m1/s1 AVSRZZMIFZBOQS-SDHSZQHLSA-N 50301130 (S)-2-((R)-2-((S)-3-(1H-imidazol-5-yl)-2-(3-(3-(trifluoromethyl)phenyl)acrylamido)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL569696 Melanocortin receptor 4 Mus musculus 3700 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301130&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487410 104155491 CHEMBL569696 ZINC49694482 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904585 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1cccc(O)c1)C(N)=O InChI=1S/C30H37N9O5/c31-27(42)23(10-5-13-35-30(32)33)38-28(43)24(15-19-6-2-1-3-7-19)39-29(44)25(16-21-17-34-18-36-21)37-26(41)12-11-20-8-4-9-22(40)14-20/h1-4,6-9,11-12,14,17-18,23-25,40H,5,10,13,15-16H2,(H2,31,42)(H,34,36)(H,37,41)(H,38,43)(H,39,44)(H4,32,33,35)/t23-,24-,25+/m1/s1 UXZKJVKZYBANRZ-SDHSZQHLSA-N 50301131 (S)-5-guanidino-2-((R)-2-((S)-2-(3-(3-hydroxyphenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)pentanamide::CHEMBL567240 Melanocortin receptor 4 Mus musculus 12740 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301131&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487411 104155492 CHEMBL567240 ZINC49694582 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904586 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1cc2cc(O)ccc2[nH]1)C(N)=O InChI=1S/C30H36N10O5/c31-26(42)22(7-4-10-35-30(32)33)38-27(43)23(11-17-5-2-1-3-6-17)39-29(45)25(14-19-15-34-16-36-19)40-28(44)24-13-18-12-20(41)8-9-21(18)37-24/h1-3,5-6,8-9,12-13,15-16,22-23,25,37,41H,4,7,10-11,14H2,(H2,31,42)(H,34,36)(H,38,43)(H,39,45)(H,40,44)(H4,32,33,35)/t22-,23-,25+/m1/s1 IIIAOCIDACPBMN-OYRHQHFDSA-N 50301133 CHEMBL568409::N-((S)-1-((R)-1-((S)-1-amino-5-guanidino-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-5-hydroxy-1H-indole-2-carboxamide Melanocortin receptor 4 Mus musculus 17200 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301133&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487413 104155494 CHEMBL568409 ZINC49679053 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904587 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccc(Cl)cc1)C(N)=O InChI=1S/C30H36ClN9O4/c31-21-11-8-19(9-12-21)10-13-26(41)38-25(16-22-17-35-18-37-22)29(44)40-24(15-20-5-2-1-3-6-20)28(43)39-23(27(32)42)7-4-14-36-30(33)34/h1-3,5-6,8-13,17-18,23-25H,4,7,14-16H2,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/t23-,24-,25+/m1/s1 CVVWWYJPDWRAEB-SDHSZQHLSA-N 50301134 (S)-2-((R)-2-((S)-2-(3-(4-chlorophenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL568577 Melanocortin receptor 4 Mus musculus 5200 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301134&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487414 104155495 CHEMBL568577 ZINC49678688 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904588 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccc(O)cc1)C(N)=O InChI=1S/C30H37N9O5/c31-27(42)23(7-4-14-35-30(32)33)38-28(43)24(15-20-5-2-1-3-6-20)39-29(44)25(16-21-17-34-18-36-21)37-26(41)13-10-19-8-11-22(40)12-9-19/h1-3,5-6,8-13,17-18,23-25,40H,4,7,14-16H2,(H2,31,42)(H,34,36)(H,37,41)(H,38,43)(H,39,44)(H4,32,33,35)/t23-,24-,25+/m1/s1 WVGXIMGLLVHHQR-SDHSZQHLSA-N 50301135 (S)-5-guanidino-2-((R)-2-((S)-2-(3-(4-hydroxyphenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)pentanamide::CHEMBL569697 Melanocortin receptor 4 Mus musculus 18130 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301135 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301135&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487415 104155496 CHEMBL569697 ZINC49694483 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904589 COc1ccc(C=CC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](CCCN=C(N)N)C(N)=O)cc1 InChI=1S/C31H39N9O5/c1-45-23-12-9-20(10-13-23)11-14-27(41)38-26(17-22-18-35-19-37-22)30(44)40-25(16-21-6-3-2-4-7-21)29(43)39-24(28(32)42)8-5-15-36-31(33)34/h2-4,6-7,9-14,18-19,24-26H,5,8,15-17H2,1H3,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/t24-,25-,26+/m1/s1 JYNLYZMGADFMLF-CYXNTTPDSA-N 50301137 (S)-2-((R)-2-((S)-3-(1H-imidazol-5-yl)-2-(3-(4-methoxyphenyl)acrylamido)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL567233 Melanocortin receptor 4 Mus musculus 11500 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301137 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301137&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487417 104155498 CHEMBL567233 ZINC49694490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904590 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccc2OCOc2c1)C(N)=O InChI=1S/C31H37N9O6/c32-28(42)22(7-4-12-36-31(33)34)39-29(43)23(13-19-5-2-1-3-6-19)40-30(44)24(15-21-16-35-17-37-21)38-27(41)11-9-20-8-10-25-26(14-20)46-18-45-25/h1-3,5-6,8-11,14,16-17,22-24H,4,7,12-13,15,18H2,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/t22-,23-,24+/m1/s1 JHFQXGKRYPWBNG-SMIHKQSGSA-N 50301140 (R)-2-((R)-2-((S)-2-(3-(benzo[d][1,3]dioxol-5-yl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL568940 Melanocortin receptor 4 Mus musculus 23600 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301140 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301140&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487286 104155501 CHEMBL568940 ZINC49678716 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904591 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cccc2OCOc12)C(N)=O InChI=1S/C31H39N9O6/c32-28(42)22(9-5-13-36-31(33)34)39-29(43)23(14-19-6-2-1-3-7-19)40-30(44)24(15-21-16-35-17-37-21)38-26(41)12-11-20-8-4-10-25-27(20)46-18-45-25/h1-4,6-8,10,16-17,22-24H,5,9,11-15,18H2,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/t22-,23-,24+/m1/s1 XLRDDIVPVKGCSM-SMIHKQSGSA-N 50301141 (S)-2-((R)-2-((S)-2-(3-(benzo[d][1,3]dioxol-4-yl)propanamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL570903 Melanocortin receptor 4 Mus musculus 25500 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301141 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301141&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487287 104155502 CHEMBL570903 ZINC49694880 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904592 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=Cc1ccc(F)cc1F)C(N)=O InChI=1S/C30H35F2N9O4/c31-20-10-8-19(22(32)14-20)9-11-26(42)39-25(15-21-16-36-17-38-21)29(45)41-24(13-18-5-2-1-3-6-18)28(44)40-23(27(33)43)7-4-12-37-30(34)35/h1-3,5-6,8-11,14,16-17,23-25H,4,7,12-13,15H2,(H2,33,43)(H,36,38)(H,39,42)(H,40,44)(H,41,45)(H4,34,35,37)/t23-,24-,25+/m1/s1 RJVMIMYECFLWOD-SDHSZQHLSA-N 50301142 (R)-2-((R)-2-((S)-2-(3-(2,4-difluorophenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL569076 Melanocortin receptor 4 Mus musculus 23500 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301142 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301142&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487288 104155503 CHEMBL569076 ZINC49679237 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904593 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCc1cnc[nH]1)C(N)=O InChI=1S/C27H37N11O4/c28-24(40)20(7-4-10-33-27(29)30)37-25(41)21(11-17-5-2-1-3-6-17)38-26(42)22(12-19-14-32-16-35-19)36-23(39)9-8-18-13-31-15-34-18/h1-3,5-6,13-16,20-22H,4,7-12H2,(H2,28,40)(H,31,34)(H,32,35)(H,36,39)(H,37,41)(H,38,42)(H4,29,30,33)/t20-,21-,22+/m1/s1 UXEANADRNJPXAY-VSKRKVRLSA-N 50301144 (S)-2-((R)-2-((S)-2-(3-(1H-imidazol-4-yl)propanamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL565474 Melanocortin receptor 4 Mus musculus 38700 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301144 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301144&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487290 104155505 CHEMBL565474 ZINC49670077 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904594 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C(F)=Cc1ccccc1)C(N)=O InChI=1S/C30H36FN9O4/c31-22(14-19-8-3-1-4-9-19)27(42)39-25(16-21-17-35-18-37-21)29(44)40-24(15-20-10-5-2-6-11-20)28(43)38-23(26(32)41)12-7-13-36-30(33)34/h1-6,8-11,14,17-18,23-25H,7,12-13,15-16H2,(H2,32,41)(H,35,37)(H,38,43)(H,39,42)(H,40,44)(H4,33,34,36)/t23-,24-,25+/m1/s1 VORCDWUGXBEFDJ-SDHSZQHLSA-N 50301145 (S)-2-((R)-2-((S)-2-(2-fluoro-3-phenylacrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL569220 Melanocortin receptor 4 Mus musculus 19200 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301145 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301145&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487291 104155506 CHEMBL569220 ZINC49679610 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904595 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C(=Cc1ccc(O)cc1)C#N)C(N)=O InChI=1S/C31H36N10O5/c32-16-21(13-20-8-10-23(42)11-9-20)28(44)40-26(15-22-17-36-18-38-22)30(46)41-25(14-19-5-2-1-3-6-19)29(45)39-24(27(33)43)7-4-12-37-31(34)35/h1-3,5-6,8-11,13,17-18,24-26,42H,4,7,12,14-15H2,(H2,33,43)(H,36,38)(H,39,45)(H,40,44)(H,41,46)(H4,34,35,37)/t24-,25-,26+/m1/s1 DNRIVOCYBHKOPB-CYXNTTPDSA-N 50301146 (S)-2-((R)-2-((S)-2-(2-cyano-3-(4-hydroxyphenyl)acrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL565900 Melanocortin receptor 4 Mus musculus 42800 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301146 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301146&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487292 104155507 CHEMBL565900 ZINC49670039 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904596 CC(=O)NC(=Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCCN=C(N)N)C(N)=O InChI=1S/C32H40N10O5/c1-20(43)39-25(15-21-9-4-2-5-10-21)29(45)42-27(17-23-18-36-19-38-23)31(47)41-26(16-22-11-6-3-7-12-22)30(46)40-24(28(33)44)13-8-14-37-32(34)35/h2-7,9-12,15,18-19,24,26-27H,8,13-14,16-17H2,1H3,(H2,33,44)(H,36,38)(H,39,43)(H,40,46)(H,41,47)(H,42,45)(H4,34,35,37)/t24-,26-,27+/m1/s1 YRRSGAOLFCVSOV-IEUSDUHPSA-N 50301147 (S)-2-((R)-2-((S)-2-(2-acetamido-3-phenylacrylamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL566764 Melanocortin receptor 4 Mus musculus 20300 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301147&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487293 104155508 CHEMBL566764 ZINC49677921 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904597 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C\C=C\c1ccccc1)C(N)=O InChI=1S/C31H39N9O4/c32-28(42)24(14-8-16-36-31(33)34)39-29(43)25(17-22-11-5-2-6-12-22)40-30(44)26(18-23-19-35-20-37-23)38-27(41)15-7-13-21-9-3-1-4-10-21/h1-7,9-13,19-20,24-26H,8,14-18H2,(H2,32,42)(H,35,37)(H,38,41)(H,39,43)(H,40,44)(H4,33,34,36)/b13-7+/t24-,25-,26+/m1/s1 KVHVZQKGTVCTQW-SGNAOXBASA-N 50301148 (S)-2-((R)-2-((S)-3-(1H-imidazol-5-yl)-2-(4-phenylbut-3-enamido)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL565688 Melanocortin receptor 4 Mus musculus 5020 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301148&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487294 104155509 CHEMBL565688 ZINC49677814 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904598 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccccc1)C(N)=O InChI=1S/C31H39N9O5/c32-28(43)23(12-7-15-36-31(33)34)39-29(44)24(16-20-8-3-1-4-9-20)40-30(45)25(17-22-18-35-19-37-22)38-27(42)14-13-26(41)21-10-5-2-6-11-21/h1-6,8-11,18-19,23-25H,7,12-17H2,(H2,32,43)(H,35,37)(H,38,42)(H,39,44)(H,40,45)(H4,33,34,36)/t23-,24-,25+/m1/s1 PLXFBHOHFXMKET-SDHSZQHLSA-N 50301149 (S)-2-((R)-2-((S)-3-(1H-imidazol-5-yl)-2-(4-oxo-4-phenylbutanamido)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL569221 Melanocortin receptor 4 Mus musculus 22750 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301149&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487295 104155510 CHEMBL569221 ZINC49679613 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904599 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CCC(=O)c1ccc(F)cc1)C(N)=O InChI=1S/C31H38FN9O5/c32-21-10-8-20(9-11-21)26(42)12-13-27(43)39-25(16-22-17-36-18-38-22)30(46)41-24(15-19-5-2-1-3-6-19)29(45)40-23(28(33)44)7-4-14-37-31(34)35/h1-3,5-6,8-11,17-18,23-25H,4,7,12-16H2,(H2,33,44)(H,36,38)(H,39,43)(H,40,45)(H,41,46)(H4,34,35,37)/t23-,24-,25+/m1/s1 GCGOAZRZURMILC-SDHSZQHLSA-N 50301150 (S)-2-((R)-2-((S)-2-(4-(4-fluorophenyl)-4-oxobutanamido)-3-(1H-imidazol-5-yl)propanamido)-3-phenylpropanamido)-5-guanidinopentanamide::CHEMBL568836 Melanocortin receptor 4 Mus musculus 12400 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301150 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301150&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487296 104155511 CHEMBL568836 ZINC49680306 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904600 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=CC=Cc1ccccc1)C(N)=O InChI=1S/C32H39N9O4/c33-29(43)25(15-9-17-37-32(34)35)40-30(44)26(18-23-13-5-2-6-14-23)41-31(45)27(19-24-20-36-21-38-24)39-28(42)16-8-7-12-22-10-3-1-4-11-22/h1-8,10-14,16,20-21,25-27H,9,15,17-19H2,(H2,33,43)(H,36,38)(H,39,42)(H,40,44)(H,41,45)(H4,34,35,37)/t25-,26-,27+/m1/s1 RHOWSTRIYYLBAZ-PFBJBMPXSA-N 50301151 CHEMBL567634::N-((S)-1-((R)-1-((S)-1-amino-5-guanidino-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-5-phenylpenta-2,4-dienamide Melanocortin receptor 4 Mus musculus 4710 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301151&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487297 104155512 CHEMBL567634 ZINC49679955 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904601 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)C=CC=Cc1ccc2OCOc2c1)C(N)=O InChI=1S/C33H39N9O6/c34-30(44)24(10-6-14-38-33(35)36)41-31(45)25(15-21-7-2-1-3-8-21)42-32(46)26(17-23-18-37-19-39-23)40-29(43)11-5-4-9-22-12-13-27-28(16-22)48-20-47-27/h1-5,7-9,11-13,16,18-19,24-26H,6,10,14-15,17,20H2,(H2,34,44)(H,37,39)(H,40,43)(H,41,45)(H,42,46)(H4,35,36,38)/t24-,25-,26+/m1/s1 ULZMJZCJOFMASA-CYXNTTPDSA-N 50301152 CHEMBL568965::N-((S)-1-((R)-1-((S)-1-amino-5-guanidino-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-5-(benzo[d][1,3]dioxol-5-yl)penta-2,4-dienamide Melanocortin receptor 4 Mus musculus 10050 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301152&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487298 104155513 CHEMBL568965 ZINC49679599 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904602 NC(N)=NCCC[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)c1ccc2OCOc2c1)C(N)=O InChI=1S/C29H35N9O6/c30-25(39)20(7-4-10-34-29(31)32)36-27(41)21(11-17-5-2-1-3-6-17)38-28(42)22(13-19-14-33-15-35-19)37-26(40)18-8-9-23-24(12-18)44-16-43-23/h1-3,5-6,8-9,12,14-15,20-22H,4,7,10-11,13,16H2,(H2,30,39)(H,33,35)(H,36,41)(H,37,40)(H,38,42)(H4,31,32,34)/t20-,21-,22+/m1/s1 HTPHOYZWPBUSID-VSKRKVRLSA-N 50301154 CHEMBL569086::N-((S)-1-((R)-1-((S)-1-amino-5-guanidino-1-oxopentan-2-ylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)benzo[d][1,3]dioxole-5-carboxamide Melanocortin receptor 4 Mus musculus 31000 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50301154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50301154&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 45487300 104155515 CHEMBL569086 ZINC49678860 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904635 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 19.3 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50904639 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.14 ChEMBL 10.1016/j.bmcl.2009.07.025 10.7270/Q2WD41JX 19635667 Ruwe, AR; Koikov, L; Abdel-Malek, Z; Haskell-Luevano, C; Dirain, ML; Portillo, F; Xiang, Z; Wortman, M; Knittel, JJ University of Cincinnati http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50986095 NCc1ccc(NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)NCc2ccccc2)cc1 InChI=1S/C26H27N5O2/c27-15-18-10-12-21(13-11-18)30-25(32)24(14-20-17-28-23-9-5-4-8-22(20)23)31-26(33)29-16-19-6-2-1-3-7-19/h1-13,17,24,28H,14-16,27H2,(H,30,32)(H2,29,31,33)/t24-/m0/s1 FJVDDQFNULKYMY-DEOSSOPVSA-N 50404043 CHEMBL2112213 Melanocortin receptor 4 Mus musculus 400 ChEMBL 10.1016/s0960-894x(03)00318-4 10.7270/Q2JD4XBW 12781199 Joseph, CG; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50404043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50404043&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71457994 163353067 CHEMBL2112213 ZINC95559305 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048114 C[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C74H92N18O15S3/c1-40-64(98)87-55(31-43-14-7-4-8-15-43)69(103)91-59(72(106)85-53(63(77)97)29-45-21-25-49(94)26-22-45)38-110-109-37-58(89-66(100)51(75)28-44-19-23-48(93)24-20-44)70(104)83-41(2)65(99)86-54(30-42-12-5-3-6-13-42)68(102)90-57-36-108-39-62(96)92(35-47(84-71(57)105)16-11-27-80-74(78)79)60(32-46-34-81-52-18-10-9-17-50(46)52)73(107)88-56(33-61(76)95)67(101)82-40/h3-10,12-15,17-26,34,40-41,47,51,53-60,81,93-94H,11,16,27-33,35-39,75H2,1-2H3,(H2,76,95)(H2,77,97)(H,82,101)(H,83,104)(H,84,105)(H,85,106)(H,86,99)(H,87,98)(H,88,107)(H,89,100)(H,90,102)(H,91,103)(H4,78,79,80)/t40-,41-,47-,51-,53-,54+,55-,56-,57+,58-,59-,60-/m0/s1 HCEITYKMCSXXGB-RSXGRFIASA-N 50427678 CHEMBL2323788 Melanocortin receptor 4 Mus musculus 705 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427678 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427678&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899978 164156553 CHEMBL2323788 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048115 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H94N20O15S3/c1-42-67(103)90-56(29-43-11-4-2-5-12-43)70(106)96-62(74(110)89-55(66(80)102)28-46-20-24-51(99)25-21-46)39-115-114-38-61(94-68(104)53(78)27-45-18-22-50(98)23-19-45)75(111)92-58(32-49-35-83-41-86-49)72(108)91-57(30-44-13-6-3-7-14-44)71(107)95-60-37-113-40-65(101)97(36-48(88-73(60)109)15-10-26-84-77(81)82)63(31-47-34-85-54-17-9-8-16-52(47)54)76(112)93-59(33-64(79)100)69(105)87-42/h2-9,11-14,16-25,34-35,41-42,48,53,55-63,85,98-99H,10,15,26-33,36-40,78H2,1H3,(H2,79,100)(H2,80,102)(H,83,86)(H,87,105)(H,88,109)(H,89,110)(H,90,103)(H,91,108)(H,92,111)(H,93,112)(H,94,104)(H,95,107)(H,96,106)(H4,81,82,84)/t42-,48-,53-,55-,56-,57+,58-,59-,60+,61-,62-,63-/m0/s1 SAUMKWJPJZDAEN-FHILOCCJSA-N 50339347 (S)-cis-(2S,5S,8S,11S,14R,19R,22S,25R,28S,31S)-22-((1H-imidazol-5-yl)methyl)-2-((1H-indol-3-yl)methyl)-5-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-19-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-11,25-dibenzyl-31-(3-guanidinopropyl)-8-methyl-3,6,9,12,20,23,26,29,33-nonaoxo-16,17,35-trithia-1,4,7,10,13,21,24,27,30-nonaazabicyclo[26.4.4]hexatriacontane-14-carboxamide::CHEMBL1688111 Melanocortin receptor 4 Mus musculus 190 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339347&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932360 125089449 CHEMBL1688111 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048174 CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 UAHFGYDRQSXQEB-BVMGHOOCSA-N 50121900 Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL439490 Melanocortin receptor 4 Mus musculus 0.200000 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50121900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50121900&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932161 104014653 CHEMBL439490 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048175 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C72H87N19O14S2/c1-39-62(96)85-53(29-40-11-4-2-5-12-40)67(101)91-59(70(104)84-52(61(75)95)28-43-20-24-47(93)25-21-43)37-107-106-36-58(90-63(97)49(73)27-42-18-22-46(92)23-19-42)71(105)88-56(32-45-35-78-38-81-45)69(103)86-54(30-41-13-6-3-7-14-41)66(100)83-51(17-10-26-79-72(76)77)64(98)87-55(31-44-34-80-50-16-9-8-15-48(44)50)68(102)89-57(33-60(74)94)65(99)82-39/h2-9,11-16,18-25,34-35,38-39,49,51-59,80,92-93H,10,17,26-33,36-37,73H2,1H3,(H2,74,94)(H2,75,95)(H,78,81)(H,82,99)(H,83,100)(H,84,104)(H,85,96)(H,86,103)(H,87,98)(H,88,105)(H,89,102)(H,90,97)(H,91,101)(H4,76,77,79)/t39-,49-,51-,52-,53-,54+,55-,56-,57-,58-,59-/m0/s1 VEIBXMZRLHAMLO-LANMVBEMSA-N 50339348 (4R,7S,10S,13S,16S,19S,22R,25S,28R)-25-((1H-imidazol-4-yl)methyl)-16-((1H-indol-3-yl)methyl)-13-(2-amino-2-oxoethyl)-N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-28-((S)-2-amino-3-(4-hydroxyphenyl)propanamido)-7,22-dibenzyl-19-(3-guanidinopropyl)-10-methyl-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxamide::CHEMBL1688107 Melanocortin receptor 4 Mus musculus 0.170000 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50339348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50339348&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932361 125089450 CHEMBL1688107 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048176 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc(cc2)-c2ccccc2)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C81H97N19O15S3/c1-46-71(106)93-60(34-47-12-5-2-6-13-47)74(109)99-66(78(113)92-59(70(84)105)33-50-23-29-57(102)30-24-50)43-118-117-42-65(97-72(107)58(82)32-49-21-27-56(101)28-22-49)79(114)95-62(37-55-39-87-45-89-55)76(111)94-61(35-48-14-7-3-8-15-48)75(110)98-64-41-116-44-69(104)100(40-54(91-77(64)112)18-11-31-88-81(85)86)67(80(115)96-63(38-68(83)103)73(108)90-46)36-51-19-25-53(26-20-51)52-16-9-4-10-17-52/h2-10,12-17,19-30,39,45-46,54,58-67,101-102H,11,18,31-38,40-44,82H2,1H3,(H2,83,103)(H2,84,105)(H,87,89)(H,90,108)(H,91,112)(H,92,113)(H,93,106)(H,94,111)(H,95,114)(H,96,115)(H,97,107)(H,98,110)(H,99,109)(H4,85,86,88)/t46-,54-,58-,59-,60-,61+,62-,63-,64+,65-,66-,67-/m0/s1 NEZJXKKVAAYZDD-FGKMWJJFSA-N 50427679 CHEMBL2323787 Melanocortin receptor 4 Mus musculus 980 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427679&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899979 164156554 CHEMBL2323787 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048177 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C79H95N19O15S3/c1-44-69(104)91-58(32-45-11-4-2-5-12-45)72(107)97-64(76(111)90-57(68(82)103)31-48-21-26-55(100)27-22-48)41-116-115-40-63(95-70(105)56(80)30-47-19-24-54(99)25-20-47)77(112)93-60(35-53-37-85-43-87-53)74(109)92-59(33-46-13-6-3-7-14-46)73(108)96-62-39-114-42-67(102)98(38-52(89-75(62)110)17-10-28-86-79(83)84)65(78(113)94-61(36-66(81)101)71(106)88-44)34-49-18-23-50-15-8-9-16-51(50)29-49/h2-9,11-16,18-27,29,37,43-44,52,56-65,99-100H,10,17,28,30-36,38-42,80H2,1H3,(H2,81,101)(H2,82,103)(H,85,87)(H,88,106)(H,89,110)(H,90,111)(H,91,104)(H,92,109)(H,93,112)(H,94,113)(H,95,105)(H,96,108)(H,97,107)(H4,83,84,86)/t44-,52-,56-,57-,58-,59+,60-,61-,62+,63-,64-,65+/m0/s1 KIRVLPVFDKQTQF-BVSPDFHBSA-N 50427680 CHEMBL2323786 Melanocortin receptor 4 Mus musculus 50 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427680 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427680&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899980 164156555 CHEMBL2323786 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048178 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C79H95N19O15S3/c1-44-69(104)91-58(32-45-11-4-2-5-12-45)72(107)97-64(76(111)90-57(68(82)103)31-48-21-26-55(100)27-22-48)41-116-115-40-63(95-70(105)56(80)30-47-19-24-54(99)25-20-47)77(112)93-60(35-53-37-85-43-87-53)74(109)92-59(33-46-13-6-3-7-14-46)73(108)96-62-39-114-42-67(102)98(38-52(89-75(62)110)17-10-28-86-79(83)84)65(78(113)94-61(36-66(81)101)71(106)88-44)34-49-18-23-50-15-8-9-16-51(50)29-49/h2-9,11-16,18-27,29,37,43-44,52,56-65,99-100H,10,17,28,30-36,38-42,80H2,1H3,(H2,81,101)(H2,82,103)(H,85,87)(H,88,106)(H,89,110)(H,90,111)(H,91,104)(H,92,109)(H,93,112)(H,94,113)(H,95,105)(H,96,108)(H,97,107)(H4,83,84,86)/t44-,52-,56-,57-,58-,59+,60-,61-,62+,63-,64-,65-/m0/s1 KIRVLPVFDKQTQF-QLFNPVIXSA-N 50427681 CHEMBL2323785 Melanocortin receptor 4 Mus musculus 220 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427681 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427681&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899981 164156556 CHEMBL2323785 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048179 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C69H89N19O15S3/c1-37-59(94)81-49(26-39-10-5-3-6-11-39)63(98)87-55(67(102)80-48(58(72)93)25-42-17-21-46(90)22-18-42)34-106-105-33-54(85-61(96)47(70)24-41-15-19-45(89)20-16-41)68(103)84-51(28-44-30-75-36-77-44)65(100)83-50(27-40-12-7-4-8-13-40)64(99)86-53-32-104-35-57(92)88(31-43(79-66(53)101)14-9-23-76-69(73)74)38(2)60(95)82-52(29-56(71)91)62(97)78-37/h3-8,10-13,15-22,30,36-38,43,47-55,89-90H,9,14,23-29,31-35,70H2,1-2H3,(H2,71,91)(H2,72,93)(H,75,77)(H,78,97)(H,79,101)(H,80,102)(H,81,94)(H,82,95)(H,83,100)(H,84,103)(H,85,96)(H,86,99)(H,87,98)(H4,73,74,76)/t37-,38-,43-,47-,48-,49-,50+,51-,52-,53+,54-,55-/m0/s1 VRRWZSTUYYSDCY-DRRBYMECSA-N 50427682 CHEMBL2323529 Melanocortin receptor 4 Mus musculus 210 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427682 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427682&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899982 164156557 CHEMBL2323529 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048180 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)[C@]23CCCN2C(=O)[C@@H](CSCC3=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C75H86N16O15S3/c1-41-65(97)84-55(29-42-11-4-2-5-12-42)69(101)89-60(72(104)83-54(64(78)96)28-45-19-23-49(93)24-20-45)38-109-108-37-59(88-67(99)52(76)27-44-17-21-48(92)22-18-44)73(105)87-57(32-47-35-79-40-81-47)71(103)86-56(30-43-13-6-3-7-14-43)70(102)90-61-36-107-39-62(94)75(25-10-26-91(75)74(61)106)51(31-46-34-80-53-16-9-8-15-50(46)53)66(98)85-58(33-63(77)95)68(100)82-41/h2-9,11-24,34-35,40-41,51-52,54-61,80,92-93H,10,25-33,36-39,76H2,1H3,(H2,77,95)(H2,78,96)(H,79,81)(H,82,100)(H,83,104)(H,84,97)(H,85,98)(H,86,103)(H,87,105)(H,88,99)(H,89,101)(H,90,102)/t41-,51+,52-,54-,55-,56+,57-,58-,59-,60-,61+,75-/m0/s1 UPVUZHSJQHSUQD-DQRIJPQFSA-N 50427683 CHEMBL2323800 Melanocortin receptor 4 Mus musculus 1270 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427683&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71720503 164156558 CHEMBL2323800 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048181 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C78H96N20O15S3/c1-43-68(104)91-57(30-44-12-4-2-5-13-44)71(107)97-63(75(111)90-56(67(81)103)29-47-21-25-52(100)26-22-47)40-116-115-39-62(95-69(105)54(79)28-46-19-23-51(99)24-20-46)76(112)93-59(33-50-36-84-42-87-50)73(109)92-58(31-45-14-6-3-7-15-45)72(108)96-61-38-114-41-66(102)98(37-49(89-74(61)110)16-10-11-27-85-78(82)83)64(32-48-35-86-55-18-9-8-17-53(48)55)77(113)94-60(34-65(80)101)70(106)88-43/h2-9,12-15,17-26,35-36,42-43,49,54,56-64,86,99-100H,10-11,16,27-34,37-41,79H2,1H3,(H2,80,101)(H2,81,103)(H,84,87)(H,88,106)(H,89,110)(H,90,111)(H,91,104)(H,92,109)(H,93,112)(H,94,113)(H,95,105)(H,96,108)(H,97,107)(H4,82,83,85)/t43-,49-,54-,56-,57-,58+,59-,60-,61+,62-,63-,64-/m0/s1 OPOVMSXOYHIUDD-UQNATJPTSA-N 50427684 CHEMBL2323799 Melanocortin receptor 4 Mus musculus 965 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427684 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427684&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899983 164156559 CHEMBL2323799 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048182 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCCN)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H94N18O15S3/c1-43-68(101)88-57(30-44-12-4-2-5-13-44)71(104)94-63(75(108)87-56(67(81)100)29-47-21-25-52(97)26-22-47)40-113-112-39-62(92-69(102)54(79)28-46-19-23-51(96)24-20-46)76(109)90-59(33-50-36-82-42-84-50)73(106)89-58(31-45-14-6-3-7-15-45)72(105)93-61-38-111-41-66(99)95(37-49(86-74(61)107)16-10-11-27-78)64(32-48-35-83-55-18-9-8-17-53(48)55)77(110)91-60(34-65(80)98)70(103)85-43/h2-9,12-15,17-26,35-36,42-43,49,54,56-64,83,96-97H,10-11,16,27-34,37-41,78-79H2,1H3,(H2,80,98)(H2,81,100)(H,82,84)(H,85,103)(H,86,107)(H,87,108)(H,88,101)(H,89,106)(H,90,109)(H,91,110)(H,92,102)(H,93,105)(H,94,104)/t43-,49-,54-,56-,57-,58+,59-,60-,61+,62-,63-,64-/m0/s1 NWHFBPXVJZXMAY-UQNATJPTSA-N 50427685 CHEMBL2323798 Melanocortin receptor 4 Mus musculus 420 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427685&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71719886 164156560 CHEMBL2323798 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048183 C[C@H]1CN2[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](CSCC2=O)C(=O)N1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O InChI=1S/C74H87N17O15S3/c1-40-34-91-61(29-46-32-79-52-16-10-9-15-50(46)52)74(106)87-57(31-62(76)94)67(99)82-41(2)65(97)84-54(27-42-11-5-3-6-12-42)68(100)90-60(72(104)83-53(64(77)96)26-45-19-23-49(93)24-20-45)37-109-108-36-59(88-66(98)51(75)25-44-17-21-48(92)22-18-44)73(105)86-56(30-47-33-78-39-80-47)70(102)85-55(28-43-13-7-4-8-14-43)69(101)89-58(71(103)81-40)35-107-38-63(91)95/h3-24,32-33,39-41,51,53-61,79,92-93H,25-31,34-38,75H2,1-2H3,(H2,76,94)(H2,77,96)(H,78,80)(H,81,103)(H,82,99)(H,83,104)(H,84,97)(H,85,102)(H,86,105)(H,87,106)(H,88,98)(H,89,101)(H,90,100)/t40-,41-,51-,53-,54-,55+,56-,57-,58+,59-,60-,61-/m0/s1 WZWRPPXTHKSPII-YVFDGVDHSA-N 50427686 CHEMBL2323797 Melanocortin receptor 4 Mus musculus 1300 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427686&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 71716237 164156561 CHEMBL2323797 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048184 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc(cc2)-c2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C83H98N20O15S3/c1-46-73(109)96-62(33-47-11-4-2-5-12-47)76(112)102-68(80(116)95-61(72(86)108)32-50-22-28-57(105)29-23-50)43-121-120-42-67(100-74(110)59(84)31-48-20-26-56(104)27-21-48)81(117)98-64(36-55-39-89-45-92-55)78(114)97-63(34-49-18-24-52(25-19-49)51-13-6-3-7-14-51)77(113)101-66-41-119-44-71(107)103(40-54(94-79(66)115)15-10-30-90-83(87)88)69(35-53-38-91-60-17-9-8-16-58(53)60)82(118)99-65(37-70(85)106)75(111)93-46/h2-9,11-14,16-29,38-39,45-46,54,59,61-69,91,104-105H,10,15,30-37,40-44,84H2,1H3,(H2,85,106)(H2,86,108)(H,89,92)(H,93,111)(H,94,115)(H,95,116)(H,96,109)(H,97,114)(H,98,117)(H,99,118)(H,100,110)(H,101,113)(H,102,112)(H4,87,88,90)/t46-,54-,59-,61-,62-,63+,64-,65-,66+,67-,68-,69-/m0/s1 JNZZLOWHYPHQNM-SDPBZCNWSA-N 50427693 CHEMBL2323796 Melanocortin receptor 4 Mus musculus 760 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427693 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427693&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899990 164156568 CHEMBL2323796 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048185 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc(I)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H93IN20O15S3/c1-41-67(104)91-56(28-42-8-3-2-4-9-42)70(107)97-62(74(111)90-55(66(81)103)27-45-17-23-51(100)24-18-45)38-116-115-37-61(95-68(105)53(79)26-43-15-21-50(99)22-16-43)75(112)93-58(31-49-34-84-40-87-49)72(109)92-57(29-44-13-19-47(78)20-14-44)71(108)96-60-36-114-39-65(102)98(35-48(89-73(60)110)10-7-25-85-77(82)83)63(30-46-33-86-54-12-6-5-11-52(46)54)76(113)94-59(32-64(80)101)69(106)88-41/h2-6,8-9,11-24,33-34,40-41,48,53,55-63,86,99-100H,7,10,25-32,35-39,79H2,1H3,(H2,80,101)(H2,81,103)(H,84,87)(H,88,106)(H,89,110)(H,90,111)(H,91,104)(H,92,109)(H,93,112)(H,94,113)(H,95,105)(H,96,108)(H,97,107)(H4,82,83,85)/t41-,48-,53-,55-,56-,57+,58-,59-,60+,61-,62-,63-/m0/s1 DQERTDAJMWQGCP-JCSVUNJHSA-N 50427687 CHEMBL2323795 Melanocortin receptor 4 Mus musculus 20 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427687 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427687&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899984 164156562 CHEMBL2323795 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048186 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C81H96N20O15S3/c1-44-71(107)94-60(31-45-10-3-2-4-11-45)74(110)100-66(78(114)93-59(70(84)106)30-47-20-25-55(103)26-21-47)41-119-118-40-65(98-72(108)57(82)29-46-18-23-54(102)24-19-46)79(115)96-62(34-53-37-87-43-90-53)76(112)95-61(32-48-17-22-49-12-5-6-13-50(49)28-48)75(111)99-64-39-117-42-69(105)101(38-52(92-77(64)113)14-9-27-88-81(85)86)67(33-51-36-89-58-16-8-7-15-56(51)58)80(116)97-63(35-68(83)104)73(109)91-44/h2-8,10-13,15-26,28,36-37,43-44,52,57,59-67,89,102-103H,9,14,27,29-35,38-42,82H2,1H3,(H2,83,104)(H2,84,106)(H,87,90)(H,91,109)(H,92,113)(H,93,114)(H,94,107)(H,95,112)(H,96,115)(H,97,116)(H,98,108)(H,99,111)(H,100,110)(H4,85,86,88)/t44-,52-,57-,59-,60-,61+,62-,63-,64+,65-,66-,67-/m0/s1 JSYBMOUNBDELGQ-OBCYGROVSA-N 50427694 CHEMBL2323794 Melanocortin receptor 4 Mus musculus 190 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427694&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899991 164156569 CHEMBL2323794 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048187 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C81H96N20O15S3/c1-44-71(107)94-60(31-45-11-3-2-4-12-45)74(110)100-66(78(114)93-59(70(84)106)30-47-22-26-54(103)27-23-47)41-119-118-40-65(98-72(108)57(82)29-46-20-24-53(102)25-21-46)79(115)96-62(34-52-37-87-43-90-52)76(112)95-61(32-49-15-9-14-48-13-5-6-17-55(48)49)75(111)99-64-39-117-42-69(105)101(38-51(92-77(64)113)16-10-28-88-81(85)86)67(33-50-36-89-58-19-8-7-18-56(50)58)80(116)97-63(35-68(83)104)73(109)91-44/h2-9,11-15,17-27,36-37,43-44,51,57,59-67,89,102-103H,10,16,28-35,38-42,82H2,1H3,(H2,83,104)(H2,84,106)(H,87,90)(H,91,109)(H,92,113)(H,93,114)(H,94,107)(H,95,112)(H,96,115)(H,97,116)(H,98,108)(H,99,111)(H,100,110)(H4,85,86,88)/t44-,51-,57-,59-,60-,61+,62-,63-,64+,65-,66-,67-/m0/s1 QYTCKLVMQSPBHM-XBDJTHPXSA-N 50427688 CHEMBL2323793 Melanocortin receptor 4 Mus musculus 130 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427688 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427688&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899985 164156563 CHEMBL2323793 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048188 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C71H90N20O15S3/c1-37-61(97)85-51(25-39-9-4-3-5-10-39)66(102)90-56(68(104)84-50(60(74)96)24-41-16-20-46(93)21-17-41)34-109-108-33-55(89-63(99)48(72)23-40-14-18-45(92)19-15-40)69(105)86-52(27-44-30-77-36-80-44)64(100)81-38(2)62(98)88-54-32-107-35-59(95)91(31-43(83-67(54)103)11-8-22-78-71(75)76)57(26-42-29-79-49-13-7-6-12-47(42)49)70(106)87-53(28-58(73)94)65(101)82-37/h3-7,9-10,12-21,29-30,36-38,43,48,50-57,79,92-93H,8,11,22-28,31-35,72H2,1-2H3,(H2,73,94)(H2,74,96)(H,77,80)(H,81,100)(H,82,101)(H,83,103)(H,84,104)(H,85,97)(H,86,105)(H,87,106)(H,88,98)(H,89,99)(H,90,102)(H4,75,76,78)/t37-,38-,43-,48-,50-,51-,52-,53-,54+,55-,56-,57-/m0/s1 APKRYKHCQYCPOP-GWRXOYJXSA-N 50427689 CHEMBL2323792 Melanocortin receptor 4 Mus musculus 20100 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427689 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427689&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899986 164156564 CHEMBL2323792 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048189 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C73H92N20O15S3/c1-39-63(99)86-52(27-40-9-3-2-4-10-40)66(102)90-57(68(104)85-51(62(76)98)26-42-17-21-47(95)22-18-42)36-111-110-35-56(89-64(100)49(74)25-41-15-19-46(94)20-16-41)69(105)88-54(29-45-32-79-38-82-45)72(108)92-24-8-14-58(92)70(106)91-55-34-109-37-61(97)93(33-44(84-67(55)103)11-7-23-80-73(77)78)59(28-43-31-81-50-13-6-5-12-48(43)50)71(107)87-53(30-60(75)96)65(101)83-39/h2-6,9-10,12-13,15-22,31-32,38-39,44,49,51-59,81,94-95H,7-8,11,14,23-30,33-37,74H2,1H3,(H2,75,96)(H2,76,98)(H,79,82)(H,83,101)(H,84,103)(H,85,104)(H,86,99)(H,87,107)(H,88,105)(H,89,100)(H,90,102)(H,91,106)(H4,77,78,80)/t39-,44-,49-,51-,52-,53-,54-,55+,56-,57-,58-,59-/m0/s1 VEILVGZVAAYSGV-LPUQDNEISA-N 50427690 CHEMBL2323791 Melanocortin receptor 4 Mus musculus 5400 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427690&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899987 164156565 CHEMBL2323791 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048190 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C76H94N18O15S3/c1-42-66(100)87-55(32-43-12-4-2-5-13-43)69(103)91-59(72(106)86-54(65(79)99)31-46-22-26-50(96)27-23-46)39-111-112-40-60(92-67(101)52(77)30-45-20-24-49(95)25-21-45)75(109)93-29-11-19-61(93)73(107)88-56(33-44-14-6-3-7-15-44)70(104)90-58-38-110-41-64(98)94(37-48(85-71(58)105)16-10-28-82-76(80)81)62(34-47-36-83-53-18-9-8-17-51(47)53)74(108)89-57(35-63(78)97)68(102)84-42/h2-9,12-15,17-18,20-27,36,42,48,52,54-62,83,95-96H,10-11,16,19,28-35,37-41,77H2,1H3,(H2,78,97)(H2,79,99)(H,84,102)(H,85,105)(H,86,106)(H,87,100)(H,88,107)(H,89,108)(H,90,104)(H,91,103)(H,92,101)(H4,80,81,82)/t42-,48-,52-,54-,55-,56+,57-,58+,59-,60-,61-,62-/m0/s1 PRYYHHFRVDNBGC-HOFFULRPSA-N 50427691 CHEMBL2323790 Melanocortin receptor 4 Mus musculus 240 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427691 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427691&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899988 164156566 CHEMBL2323790 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51048191 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N2C[C@H](CCCN=C(N)N)NC(=O)[C@@H](CSCC2=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C80H96N18O15S3/c1-45-70(104)91-59(34-46-14-5-2-6-15-46)74(108)97-65(77(111)90-58(69(83)103)33-50-25-29-54(100)30-26-50)43-116-115-42-64(95-71(105)56(81)32-49-23-27-53(99)28-24-49)78(112)93-60(35-47-16-7-3-8-17-47)73(107)92-61(36-48-18-9-4-10-19-48)75(109)96-63-41-114-44-68(102)98(40-52(89-76(63)110)20-13-31-86-80(84)85)66(37-51-39-87-57-22-12-11-21-55(51)57)79(113)94-62(38-67(82)101)72(106)88-45/h2-12,14-19,21-30,39,45,52,56,58-66,87,99-100H,13,20,31-38,40-44,81H2,1H3,(H2,82,101)(H2,83,103)(H,88,106)(H,89,110)(H,90,111)(H,91,104)(H,92,107)(H,93,112)(H,94,113)(H,95,105)(H,96,109)(H,97,108)(H4,84,85,86)/t45-,52-,56-,58-,59-,60-,61+,62-,63+,64-,65-,66-/m0/s1 GZWGEWCWRAMJIB-TWLSXMBOSA-N 50427692 CHEMBL2323789 Melanocortin receptor 4 Mus musculus 290 ChEMBL 10.1021/jm301253y 10.7270/Q2NS0W8S 23432160 Singh, A; Dirain, M; Witek, R; Rocca, JR; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50427692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50427692&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91899989 164156567 CHEMBL2323789 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51000820 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C64H79N15O13S2/c1-36-55(84)74-47(30-37-12-5-2-6-13-37)61(90)79-52(63(92)73-46(54(67)83)29-41-21-25-43(81)26-22-41)35-94-93-34-51(78-56(85)44(65)28-40-19-23-42(80)24-20-40)62(91)72-45(18-11-27-70-64(68)69)57(86)75-48(31-38-14-7-3-8-15-38)59(88)76-49(32-39-16-9-4-10-17-39)60(89)77-50(33-53(66)82)58(87)71-36/h2-10,12-17,19-26,36,44-52,80-81H,11,18,27-35,65H2,1H3,(H2,66,82)(H2,67,83)(H,71,87)(H,72,91)(H,73,92)(H,74,84)(H,75,86)(H,76,88)(H,77,89)(H,78,85)(H,79,90)(H4,68,69,70)/t36-,44-,45-,46-,47-,48-,49-,50-,51-,52-/m0/s1 WGLRFTCHAYWLOR-FPWNCKOBSA-N 50410195 CHEMBL2096710 Melanocortin receptor 4 Mus musculus 275 ChEMBL 10.1021/jm049620r 10.7270/Q21N80MK 15509165 Wilczynski, A; Wang, XS; Bauzo, RM; Xiang, Z; Shaw, AM; Millard, WJ; Richards, NG; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410195&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900691 163359219 CHEMBL2096710 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50999809 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CSSSSC[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)C(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NN InChI=1S/C65H80N16O14S4/c1-36-56(87)75-46(29-37-12-5-2-6-13-37)61(92)79-52(64(95)74-45(54(85)55(67)86)28-40-19-23-42(82)24-20-40)35-97-99-98-96-34-51(80-62(93)50(81-70)32-41-21-25-43(83)26-22-41)63(94)73-44(18-11-27-71-65(68)69)57(88)76-47(30-38-14-7-3-8-15-38)59(90)77-48(31-39-16-9-4-10-17-39)60(91)78-49(33-53(66)84)58(89)72-36/h2-10,12-17,19-26,36,44-52,81-83H,11,18,27-35,70H2,1H3,(H2,66,84)(H2,67,86)(H,72,89)(H,73,94)(H,74,95)(H,75,87)(H,76,88)(H,77,90)(H,78,91)(H,79,92)(H,80,93)(H4,68,69,71)/t36-,44+,45-,46+,47-,48+,49-,50-,51+,52+/m0/s1 OKOCHODOEYLAGS-IYYUMRKJSA-N 50144883 (3S)-4-(4-hydroxyphenyl)-2-oxo-3-{[(6S,9R,12S,15S,18R,21S,24R,27S)-9,18,21-tribenzyl-15-(carbamoylmethyl)-24-{3-[(diaminomethylidene)amino]propyl}-27-[(2S)-2-hydrazinyl-3-(4-hydroxyphenyl)propanamido]-12-methyl-8,11,14,17,20,23,26-heptaoxo-1,2,3,4-tetrathia-7,10,13,16,19,22,25-heptaazacyclooctacosan-6-yl]formamido}butanamide::CHEMBL409190 Melanocortin receptor 4 Mus musculus 158.49 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144883&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932915 104033908 CHEMBL409190 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50999811 CC(C)C[C@@H]1NC(=O)[C@@H]2CSSSSC[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CSSSSC[C@H](NNC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc4c[nH]cn4)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N2)NC(=O)[C@H](CSSSSC[C@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSSSC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC3=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C(C)C)[C@@H](C)O InChI=1S/C169H244N50O47S16/c1-80(2)58-103-138(238)184-69-127(228)189-100(47-50-124(170)225)141(241)192-101(48-51-125(171)226)143(243)214-131(83(7)8)166(266)219-57-27-38-123(219)162(262)211-119-76-272-279-275-267-71-114(153(253)190-97(133(233)134(173)234)34-23-53-181-167(174)175)206-149(249)108(63-92-39-43-95(223)44-40-92)200-156(256)116-73-269-277-276-268-72-115(154(254)191-98(35-24-54-182-168(176)177)139(239)198-106(61-90-30-19-15-20-31-90)146(246)199-107(62-91-32-21-16-22-33-91)147(247)203-111(66-126(172)227)144(244)187-85(10)136(236)195-105(148(248)208-116)60-89-28-17-14-18-29-89)207-150(250)109(64-93-41-45-96(224)46-42-93)201-157(257)120-77-273-280-278-270-74-117(155(255)196-103)209-152(252)113(70-220)205-142(242)102(49-52-128(229)230)193-151(251)110(65-94-68-180-79-185-94)202-145(245)104(59-81(3)4)197-140(240)99(36-25-55-183-169(178)179)194-163(263)130(82(5)6)213-160(260)121(217-216-88(13)222)78-274-282-281-271-75-118(210-159(119)259)158(258)204-112(67-129(231)232)165(265)218-56-26-37-122(218)161(261)188-84(9)135(235)186-86(11)137(237)215-132(87(12)221)164(264)212-120/h14-22,28-33,39-46,68,79-87,97-123,130-132,217,220-221,223-224H,23-27,34-38,47-67,69-78H2,1-13H3,(H2,170,225)(H2,171,226)(H2,172,227)(H2,173,234)(H,180,185)(H,184,238)(H,186,235)(H,187,244)(H,188,261)(H,189,228)(H,190,253)(H,191,254)(H,192,241)(H,193,251)(H,194,263)(H,195,236)(H,196,255)(H,197,240)(H,198,239)(H,199,246)(H,200,256)(H,201,257)(H,202,245)(H,203,247)(H,204,258)(H,205,242)(H,206,249)(H,207,250)(H,208,248)(H,209,252)(H,210,259)(H,211,262)(H,212,264)(H,213,260)(H,214,243)(H,215,237)(H,216,222)(H,229,230)(H,231,232)(H4,174,175,181)(H4,176,177,182)(H4,178,179,183)/t84-,85-,86-,87+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,130-,131-,132-/m0/s1 MYQDHXIMPMJXBQ-MNQAAEEESA-N 50144871 CHEMBL428134 Melanocortin receptor 4 Mus musculus 3.47 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144871&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44310103 104033896 CHEMBL428134 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50999812 C[C@@H]1NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(=O)NC(NC(=O)C(=O)[C@@H](Cc2ccccc2)NC1=O)C(=O)NN[C@H](Cc1ccc(O)cc1)C(=O)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C66H79N17O16/c1-35-57(91)75-45(29-36-12-5-2-6-13-36)54(89)64(98)81-56(65(99)83-82-46(53(88)55(69)90)30-40-21-25-42(85)26-22-40)80-52(87)34-50(76-58(92)43(67)28-39-19-23-41(84)24-20-39)63(97)74-44(18-11-27-72-66(70)71)59(93)77-47(31-37-14-7-3-8-15-37)61(95)78-48(32-38-16-9-4-10-17-38)62(96)79-49(33-51(68)86)60(94)73-35/h2-10,12-17,19-26,35,43-50,56,82,84-85H,11,18,27-34,67H2,1H3,(H2,68,86)(H2,69,90)(H,73,94)(H,74,97)(H,75,91)(H,76,92)(H,77,93)(H,78,95)(H,79,96)(H,80,87)(H,81,98)(H,83,99)(H4,70,71,72)/t35-,43-,44-,45+,46+,47+,48-,49+,50-,56?/m0/s1 IACONDRWYPLPQZ-WKNXYHTMSA-N 50144878 CHEMBL402258::Tyr-c[Asp-Arg-Phe-Phe-Asn-Ala-Phe-Dpr]-Tyr-NH2 Melanocortin receptor 4 Mus musculus 1258.93 ChEMBL 10.1021/jm0303608 10.7270/Q2474BM0 15084118 Wilczynski, A; Wang, XS; Joseph, CG; Xiang, Z; Bauzo, RM; Scott, JW; Sorensen, NB; Shaw, AM; Millard, WJ; Richards, NG; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50144878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50144878&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91932911 104033903 CHEMBL402258 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50998956 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C33H42N10O5/c1-20(44)40-27(16-24-17-37-19-39-24)31(47)42-26(14-21-8-3-2-4-9-21)30(46)41-25(12-7-13-38-33(35)36)32(48)43-18-23-11-6-5-10-22(23)15-28(43)29(34)45/h2-6,8-11,17,19,25-28H,7,12-16,18H2,1H3,(H2,34,45)(H,37,39)(H,40,44)(H,41,46)(H,42,47)(H4,35,36,38)/t25-,26+,27-,28-/m0/s1 MNPGXWWVUBHRNN-PUHABZHSSA-N 50409674 CHEMBL2096693 Melanocortin receptor 4 Mus musculus 8500 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50409674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50409674&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10349384 163358698 CHEMBL2096693 ZINC84671770 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50998957 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C33H42N10O5/c1-20(44)40-27(16-24-17-37-19-39-24)31(47)42-26(14-21-8-3-2-4-9-21)30(46)41-25(12-7-13-38-33(35)36)32(48)43-18-23-11-6-5-10-22(23)15-28(43)29(34)45/h2-6,8-11,17,19,25-28H,7,12-16,18H2,1H3,(H2,34,45)(H,37,39)(H,40,44)(H,41,46)(H,42,47)(H4,35,36,38)/t25-,26+,27-,28+/m0/s1 MNPGXWWVUBHRNN-ZVBOOHQUSA-N 50409673 CHEMBL2096745 Melanocortin receptor 4 Mus musculus 39400 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50409673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50409673&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10897631 163358697 CHEMBL2096745 ZINC84651828 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001272 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C73H87N17O16/c1-40-63(96)83-54(31-42-15-7-4-8-16-42)71(104)89-73(2,72(105)106)90(59(62(77)95)32-44-22-26-48(92)27-23-44)61(94)36-58(84-64(97)50(75)29-43-20-24-47(91)25-21-43)70(103)87-56(34-46-38-78-39-80-46)69(102)85-53(30-41-13-5-3-6-14-41)67(100)82-52(19-11-12-28-74)65(98)86-55(33-45-37-79-51-18-10-9-17-49(45)51)68(101)88-57(35-60(76)93)66(99)81-40/h3-10,13-18,20-27,37-40,50,52-59,79,91-92H,11-12,19,28-36,74-75H2,1-2H3,(H2,76,93)(H2,77,95)(H,78,80)(H,81,99)(H,82,100)(H,83,96)(H,84,97)(H,85,102)(H,86,98)(H,87,103)(H,88,101)(H,89,104)(H,105,106)/t40-,50-,52-,53+,54-,55-,56-,57-,58-,59-,73?/m0/s1 YBPUPHOEVCKWNW-HNSJQOHDSA-N 50410395 CHEMBL2096731 Melanocortin receptor 4 Mus musculus 8600 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410395&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900697 163359419 CHEMBL2096731 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001287 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C70H80N16O16/c1-37-60(92)79-51(28-40-14-8-5-9-15-40)68(100)85-70(3,69(101)102)86(56(59(73)91)29-42-20-24-46(88)25-21-42)58(90)33-55(81-62(94)48(71)26-41-18-22-45(87)23-19-41)67(99)83-53(31-44-35-74-36-76-44)66(98)82-50(27-39-12-6-4-7-13-39)63(95)77-38(2)61(93)80-52(30-43-34-75-49-17-11-10-16-47(43)49)65(97)84-54(32-57(72)89)64(96)78-37/h4-25,34-38,48,50-56,75,87-88H,26-33,71H2,1-3H3,(H2,72,89)(H2,73,91)(H,74,76)(H,77,95)(H,78,96)(H,79,92)(H,80,93)(H,81,94)(H,82,98)(H,83,99)(H,84,97)(H,85,100)(H,101,102)/t37-,38-,48-,50+,51-,52-,53-,54-,55-,56-,70?/m0/s1 IJMHIZWJFPYSHW-XFTWKXAVSA-N 50410406 CHEMBL2096723 Melanocortin receptor 4 Mus musculus 32.5 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410406&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900707 163359430 CHEMBL2096723 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001289 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCc3ccccc3C2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C78H91N17O16/c1-43-66(101)88-58(36-45-16-7-4-8-17-45)72(107)93-77(2,75(110)111)95(62(65(81)100)37-47-25-29-52(97)30-26-47)64(99)40-61(89-67(102)54(79)34-46-23-27-51(96)28-24-46)73(108)94-78(32-31-48-18-9-10-19-49(48)41-78)74(109)92-57(35-44-14-5-3-6-15-44)70(105)87-56(22-13-33-84-76(82)83)68(103)90-59(38-50-42-85-55-21-12-11-20-53(50)55)71(106)91-60(39-63(80)98)69(104)86-43/h3-12,14-21,23-30,42-43,54,56-62,85,96-97H,13,22,31-41,79H2,1-2H3,(H2,80,98)(H2,81,100)(H,86,104)(H,87,105)(H,88,101)(H,89,102)(H,90,103)(H,91,106)(H,92,109)(H,93,107)(H,94,108)(H,110,111)(H4,82,83,84)/t43-,54-,56-,57+,58-,59-,60-,61-,62-,77?,78?/m0/s1 VDJFVHLGBIRCKY-RXMXWGMASA-N 50410407 CHEMBL2096715 Melanocortin receptor 4 Mus musculus 115 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410407&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900708 163359431 CHEMBL2096715 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001292 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H89N19O16/c1-41-66(102)89-56(31-42-12-4-3-5-13-42)74(110)95-77(2,75(111)112)96(62(65(80)101)32-44-23-27-50(98)28-24-44)64(100)37-61(90-67(103)53(78)30-43-21-25-49(97)26-22-43)73(109)93-59(35-48-39-83-40-86-48)72(108)92-57(33-46-16-10-15-45-14-6-7-17-51(45)46)70(106)88-55(20-11-29-84-76(81)82)68(104)91-58(34-47-38-85-54-19-9-8-18-52(47)54)71(107)94-60(36-63(79)99)69(105)87-41/h3-10,12-19,21-28,38-41,53,55-62,85,97-98H,11,20,29-37,78H2,1-2H3,(H2,79,99)(H2,80,101)(H,83,86)(H,87,105)(H,88,106)(H,89,102)(H,90,103)(H,91,104)(H,92,108)(H,93,109)(H,94,107)(H,95,110)(H,111,112)(H4,81,82,84)/t41-,53-,55-,56-,57+,58-,59-,60-,61-,62-,77?/m0/s1 VFEXJLVWDIPOPO-ZILZEKFXSA-N 50410400 CHEMBL2096818 Melanocortin receptor 4 Mus musculus 0.57 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410400 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410400&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900701 163359424 CHEMBL2096818 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001304 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C75H88N18O16/c1-41-64(99)86-56(33-43-14-7-4-8-15-43)72(107)92-75(2,73(108)109)93(60(63(78)98)35-45-22-27-51(95)28-23-45)62(97)38-59(87-65(100)52(76)31-44-20-25-50(94)26-21-44)71(106)90-57(36-49-39-81-40-83-49)70(105)89-54(32-42-12-5-3-6-13-42)68(103)85-53(18-11-29-82-74(79)80)66(101)88-55(69(104)91-58(37-61(77)96)67(102)84-41)34-46-19-24-47-16-9-10-17-48(47)30-46/h3-10,12-17,19-28,30,39-41,52-60,94-95H,11,18,29,31-38,76H2,1-2H3,(H2,77,96)(H2,78,98)(H,81,83)(H,84,102)(H,85,103)(H,86,99)(H,87,100)(H,88,101)(H,89,105)(H,90,106)(H,91,104)(H,92,107)(H,108,109)(H4,79,80,82)/t41-,52-,53-,54+,55+,56-,57-,58-,59-,60-,75?/m0/s1 VKIVIEKNSBJNLA-PIFUUTIXSA-N 50410397 CHEMBL2096718 Melanocortin receptor 4 Mus musculus 0.67 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410397 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410397&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900699 163359421 CHEMBL2096718 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001307 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C72H86N18O16/c1-39-61(96)83-52(30-41-14-7-4-8-15-41)67(102)88-72(2,70(105)106)90(56(60(75)95)31-43-21-25-48(92)26-22-43)59(94)35-55(84-62(97)49(73)28-42-19-23-47(91)24-20-42)66(101)86-53(33-46-36-78-38-80-46)65(100)85-51(29-40-12-5-3-6-13-40)64(99)82-50(18-11-27-79-71(76)77)69(104)89-37-45-17-10-9-16-44(45)32-57(89)68(103)87-54(34-58(74)93)63(98)81-39/h3-10,12-17,19-26,36,38-39,49-57,91-92H,11,18,27-35,37,73H2,1-2H3,(H2,74,93)(H2,75,95)(H,78,80)(H,81,98)(H,82,99)(H,83,96)(H,84,97)(H,85,100)(H,86,101)(H,87,103)(H,88,102)(H,105,106)(H4,76,77,79)/t39-,49-,50-,51+,52-,53-,54-,55-,56-,57-,72?/m0/s1 XLEDYEJZOMFGJB-KFTZSVNWSA-N 50410404 CHEMBL2096720 Melanocortin receptor 4 Mus musculus 260 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410404 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410404&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900705 163359428 CHEMBL2096720 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001308 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C72H87N17O16/c1-39-61(95)82-52(33-41-15-7-4-8-16-41)67(101)87-72(2,70(104)105)89(57(60(75)94)34-43-23-27-46(91)28-24-43)59(93)37-55(86-62(96)48(73)31-42-21-25-45(90)26-22-42)69(103)88-30-12-20-56(88)68(102)85-51(32-40-13-5-3-6-14-40)65(99)81-50(19-11-29-78-71(76)77)63(97)83-53(35-44-38-79-49-18-10-9-17-47(44)49)66(100)84-54(36-58(74)92)64(98)80-39/h3-10,13-18,21-28,38-39,48,50-57,79,90-91H,11-12,19-20,29-37,73H2,1-2H3,(H2,74,92)(H2,75,94)(H,80,98)(H,81,99)(H,82,95)(H,83,97)(H,84,100)(H,85,102)(H,86,96)(H,87,101)(H,104,105)(H4,76,77,78)/t39-,48-,50-,51+,52-,53-,54-,55-,56-,57-,72?/m0/s1 SEYGCFZCZOOPJP-KMSOYGCPSA-N 50410412 CHEMBL2096725 Melanocortin receptor 4 Mus musculus 0.63 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410412&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900712 163359436 CHEMBL2096725 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001312 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C76H89N17O16/c1-42-65(99)86-57(36-45-19-10-5-11-20-45)73(107)92-76(2,74(108)109)93(61(64(79)98)37-47-26-30-50(95)31-27-47)63(97)40-60(87-66(100)52(77)33-46-24-28-49(94)29-25-46)72(106)89-56(35-44-17-8-4-9-18-44)70(104)88-55(34-43-15-6-3-7-16-43)69(103)85-54(23-14-32-82-75(80)81)67(101)90-58(38-48-41-83-53-22-13-12-21-51(48)53)71(105)91-59(39-62(78)96)68(102)84-42/h3-13,15-22,24-31,41-42,52,54-61,83,94-95H,14,23,32-40,77H2,1-2H3,(H2,78,96)(H2,79,98)(H,84,102)(H,85,103)(H,86,99)(H,87,100)(H,88,104)(H,89,106)(H,90,101)(H,91,105)(H,92,107)(H,108,109)(H4,80,81,82)/t42-,52-,54-,55+,56-,57-,58-,59-,60-,61-,76?/m0/s1 YNTGNBUNWBJHKM-UEIAFFDZSA-N 50410414 CHEMBL2096714 Melanocortin receptor 4 Mus musculus 0.64 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410414&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900714 163359438 CHEMBL2096714 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001314 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O InChI=1S/C50H69N15O9/c1-3-4-16-35(58-29(2)66)43(68)64-41-25-42(67)65-45(70)36(18-10-11-20-51)59-47(72)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(69)37(19-12-21-55-50(52)53)60-46(71)38(22-30-13-6-5-7-14-30)61-48(73)40(63-49(41)74)24-32-27-54-28-57-32/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25,51H2,1-2H3,(H,54,57)(H,58,66)(H,59,72)(H,60,71)(H,61,73)(H,62,69)(H,63,74)(H,64,68)(H4,52,53,55)(H,65,67,70)/t35-,36-,37-,38+,39-,40-,41-/m0/s1 LXEXKGVAQWUHCI-MFVUMRCOSA-N 50410399 CHEMBL2096712 Melanocortin receptor 4 Mus musculus 0.053 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410399 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410399&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 70691329 163359423 CHEMBL2096712 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001320 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C73H87N19O16/c1-39-62(98)85-53(30-41-14-7-4-8-15-41)70(106)91-73(2,71(107)108)92(58(61(76)97)31-43-21-25-47(94)26-22-43)60(96)35-57(86-63(99)49(74)28-42-19-23-46(93)24-20-42)69(105)89-55(33-45-37-79-38-82-45)68(104)87-52(29-40-12-5-3-6-13-40)66(102)84-51(18-11-27-80-72(77)78)64(100)88-54(32-44-36-81-50-17-10-9-16-48(44)50)67(103)90-56(34-59(75)95)65(101)83-39/h3-10,12-17,19-26,36-39,49,51-58,81,93-94H,11,18,27-35,74H2,1-2H3,(H2,75,95)(H2,76,97)(H,79,82)(H,83,101)(H,84,102)(H,85,98)(H,86,99)(H,87,104)(H,88,100)(H,89,105)(H,90,103)(H,91,106)(H,107,108)(H4,77,78,80)/t39-,49-,51-,52+,53+,54-,55-,56-,57-,58-,73?/m0/s1 VQYHLIUSSLKEAO-FNGDFXFOSA-N 50410393 CHEMBL2096819 Melanocortin receptor 4 Mus musculus 0.66 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410393&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900695 163359417 CHEMBL2096819 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001322 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C67H84N18O16/c1-36-56(91)78-47(29-38-13-7-4-8-14-38)62(97)83-67(2,65(100)101)85(52(55(70)90)30-40-19-23-43(87)24-20-40)54(89)33-50(79-57(92)44(68)27-39-17-21-42(86)22-18-39)61(96)81-48(31-41-34-73-35-75-41)60(95)80-46(28-37-11-5-3-6-12-37)59(94)77-45(15-9-25-74-66(71)72)64(99)84-26-10-16-51(84)63(98)82-49(32-53(69)88)58(93)76-36/h3-8,11-14,17-24,34-36,44-52,86-87H,9-10,15-16,25-33,68H2,1-2H3,(H2,69,88)(H2,70,90)(H,73,75)(H,76,93)(H,77,94)(H,78,91)(H,79,92)(H,80,95)(H,81,96)(H,82,98)(H,83,97)(H,100,101)(H4,71,72,74)/t36-,44-,45-,46+,47-,48-,49-,50-,51-,52-,67?/m0/s1 DFSDYEQMHZIDQN-GZFWIBJLSA-N 50410396 CHEMBL2096716 Melanocortin receptor 4 Mus musculus 7200 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410396 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410396&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900698 163359420 CHEMBL2096716 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001325 C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C65H82N18O16/c1-34-55(90)78-48(30-51(67)86)58(93)75-35(2)54(89)77-46(27-37-13-8-5-9-14-37)62(97)82-65(3,63(98)99)83(50(53(68)88)28-39-18-22-42(85)23-19-39)52(87)31-49(79-56(91)43(66)25-38-16-20-41(84)21-17-38)61(96)81-47(29-40-32-71-33-73-40)60(95)80-45(26-36-11-6-4-7-12-36)59(94)76-44(57(92)74-34)15-10-24-72-64(69)70/h4-9,11-14,16-23,32-35,43-50,84-85H,10,15,24-31,66H2,1-3H3,(H2,67,86)(H2,68,88)(H,71,73)(H,74,92)(H,75,93)(H,76,94)(H,77,89)(H,78,90)(H,79,91)(H,80,95)(H,81,96)(H,82,97)(H,98,99)(H4,69,70,72)/t34-,35-,43-,44-,45+,46-,47-,48-,49-,50-,65?/m0/s1 LCUVTXMIBHENSA-CUHJIAEXSA-N 50410402 CHEMBL2096724 Melanocortin receptor 4 Mus musculus 710 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410402 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410402&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900703 163359426 CHEMBL2096724 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001328 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C72H82N16O16/c1-39-62(94)80-51(29-40-12-5-3-6-13-40)68(100)86-72(2,71(103)104)88(58(61(75)93)31-43-21-25-47(90)26-22-43)60(92)35-55(81-63(95)49(73)28-42-19-23-46(89)24-20-42)67(99)82-53(33-45-37-76-38-78-45)66(98)85-56(30-41-14-7-4-8-15-41)70(102)87-27-11-18-57(87)69(101)84-52(32-44-36-77-50-17-10-9-16-48(44)50)65(97)83-54(34-59(74)91)64(96)79-39/h3-10,12-17,19-26,36-39,49,51-58,77,89-90H,11,18,27-35,73H2,1-2H3,(H2,74,91)(H2,75,93)(H,76,78)(H,79,96)(H,80,94)(H,81,95)(H,82,99)(H,83,97)(H,84,101)(H,85,98)(H,86,100)(H,103,104)/t39-,49-,51-,52-,53-,54-,55-,56+,57-,58-,72?/m0/s1 YNOJBDMJAJBSSK-QRPDVHSMSA-N 50410413 CHEMBL2096730 Melanocortin receptor 4 Mus musculus 4300 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410413&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900713 163359437 CHEMBL2096730 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001337 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc(cc2)-c2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C77H90N18O16/c1-43-66(101)88-58(35-45-15-8-4-9-16-45)74(109)94-77(2,75(110)111)95(62(65(80)100)37-48-24-30-53(97)31-25-48)64(99)40-61(89-67(102)54(78)33-46-22-28-52(96)29-23-46)73(108)92-59(38-51-41-83-42-85-51)72(107)91-56(34-44-13-6-3-7-14-44)70(105)87-55(19-12-32-84-76(81)82)68(103)90-57(71(106)93-60(39-63(79)98)69(104)86-43)36-47-20-26-50(27-21-47)49-17-10-5-11-18-49/h3-11,13-18,20-31,41-43,54-62,96-97H,12,19,32-40,78H2,1-2H3,(H2,79,98)(H2,80,100)(H,83,85)(H,86,104)(H,87,105)(H,88,101)(H,89,102)(H,90,103)(H,91,107)(H,92,108)(H,93,106)(H,94,109)(H,110,111)(H4,81,82,84)/t43-,54-,55-,56+,57-,58-,59-,60-,61-,62-,77?/m0/s1 YGTFIKMAJAIPOE-ROLYAUOSSA-N 50410394 CHEMBL2096719 Melanocortin receptor 4 Mus musculus 42.6 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410394 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410394&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900696 163359418 CHEMBL2096719 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001339 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C73H87N19O16/c1-39-62(98)85-53(30-41-14-7-4-8-15-41)70(106)91-73(2,71(107)108)92(58(61(76)97)31-43-21-25-47(94)26-22-43)60(96)35-57(86-63(99)49(74)28-42-19-23-46(93)24-20-42)69(105)89-55(33-45-37-79-38-82-45)68(104)87-52(29-40-12-5-3-6-13-40)66(102)84-51(18-11-27-80-72(77)78)64(100)88-54(32-44-36-81-50-17-10-9-16-48(44)50)67(103)90-56(34-59(75)95)65(101)83-39/h3-10,12-17,19-26,36-39,49,51-58,81,93-94H,11,18,27-35,74H2,1-2H3,(H2,75,95)(H2,76,97)(H,79,82)(H,83,101)(H,84,102)(H,85,98)(H,86,99)(H,87,104)(H,88,100)(H,89,105)(H,90,103)(H,91,106)(H,107,108)(H4,77,78,80)/t39-,49-,51-,52+,53-,54-,55-,56-,57-,58-,73?/m0/s1 VQYHLIUSSLKEAO-OTUSEEPMSA-N 50410408 CHEMBL2096713 Melanocortin receptor 4 Mus musculus 0.13 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410408&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900709 163359432 CHEMBL2096713 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001342 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc(cc2)-c2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C79H91N19O16/c1-43-68(104)91-59(33-44-12-5-3-6-13-44)76(112)97-79(2,77(113)114)98(64(67(82)103)35-47-23-29-53(100)30-24-47)66(102)39-63(92-69(105)55(80)32-45-21-27-52(99)28-22-45)75(111)95-61(37-51-41-85-42-88-51)74(110)93-58(34-46-19-25-49(26-20-46)48-14-7-4-8-15-48)72(108)90-57(18-11-31-86-78(83)84)70(106)94-60(36-50-40-87-56-17-10-9-16-54(50)56)73(109)96-62(38-65(81)101)71(107)89-43/h3-10,12-17,19-30,40-43,55,57-64,87,99-100H,11,18,31-39,80H2,1-2H3,(H2,81,101)(H2,82,103)(H,85,88)(H,89,107)(H,90,108)(H,91,104)(H,92,105)(H,93,110)(H,94,106)(H,95,111)(H,96,109)(H,97,112)(H,113,114)(H4,83,84,86)/t43-,55-,57-,58+,59-,60-,61-,62-,63-,64-,79?/m0/s1 MVCDKVTUKAVIJS-DJHXQOHVSA-N 50410401 CHEMBL2096729 Melanocortin receptor 4 Mus musculus 0.57 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410401 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410401&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900702 163359425 CHEMBL2096729 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001344 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C75H88N18O16/c1-41-64(99)86-56(33-43-14-7-4-8-15-43)72(107)92-75(2,73(108)109)93(60(63(78)98)35-45-22-27-51(95)28-23-45)62(97)38-59(87-65(100)52(76)31-44-20-25-50(94)26-21-44)71(106)90-57(36-49-39-81-40-83-49)70(105)89-54(32-42-12-5-3-6-13-42)68(103)85-53(18-11-29-82-74(79)80)66(101)88-55(69(104)91-58(37-61(77)96)67(102)84-41)34-46-19-24-47-16-9-10-17-48(47)30-46/h3-10,12-17,19-28,30,39-41,52-60,94-95H,11,18,29,31-38,76H2,1-2H3,(H2,77,96)(H2,78,98)(H,81,83)(H,84,102)(H,85,103)(H,86,99)(H,87,100)(H,88,101)(H,89,105)(H,90,106)(H,91,104)(H,92,107)(H,108,109)(H4,79,80,82)/t41-,52-,53-,54+,55-,56-,57-,58-,59-,60-,75?/m0/s1 VKIVIEKNSBJNLA-KALNRBGGSA-N 50410403 CHEMBL2096717 Melanocortin receptor 4 Mus musculus 0.27 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410403 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410403&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900704 163359427 CHEMBL2096717 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001347 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C70H85N17O16/c1-37-59(93)81-50(30-39-13-6-4-7-14-39)65(99)80-49(19-12-28-76-69(74)75)62(96)84-52(33-43-36-77-48-18-11-10-17-46(43)48)66(100)85-53(34-56(72)90)63(97)78-38(2)60(94)82-51(31-40-15-8-5-9-16-40)67(101)86-70(3,68(102)103)87(55(58(73)92)32-42-22-26-45(89)27-23-42)57(91)35-54(64(98)79-37)83-61(95)47(71)29-41-20-24-44(88)25-21-41/h4-11,13-18,20-27,36-38,47,49-55,77,88-89H,12,19,28-35,71H2,1-3H3,(H2,72,90)(H2,73,92)(H,78,97)(H,79,98)(H,80,99)(H,81,93)(H,82,94)(H,83,95)(H,84,96)(H,85,100)(H,86,101)(H,102,103)(H4,74,75,76)/t37-,38-,47-,49-,50+,51-,52-,53-,54-,55-,70?/m0/s1 AHYBINIDLPZASF-QHCAJBRISA-N 50410398 CHEMBL2096721 Melanocortin receptor 4 Mus musculus 0.36 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410398&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900700 163359422 CHEMBL2096721 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001350 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C69H85N19O16/c1-36-58(94)81-48(27-37-10-4-3-5-11-37)64(100)86-69(2,67(103)104)88(54(57(72)93)28-39-18-22-43(90)23-19-39)56(92)32-51(82-59(95)45(70)26-38-16-20-42(89)21-17-38)63(99)85-52(30-41-34-75-35-78-41)66(102)87-25-9-15-53(87)65(101)80-47(14-8-24-76-68(73)74)60(96)83-49(29-40-33-77-46-13-7-6-12-44(40)46)62(98)84-50(31-55(71)91)61(97)79-36/h3-7,10-13,16-23,33-36,45,47-54,77,89-90H,8-9,14-15,24-32,70H2,1-2H3,(H2,71,91)(H2,72,93)(H,75,78)(H,79,97)(H,80,101)(H,81,94)(H,82,95)(H,83,96)(H,84,98)(H,85,99)(H,86,100)(H,103,104)(H4,73,74,76)/t36-,45-,47-,48-,49-,50-,51-,52-,53-,54-,69?/m0/s1 ICLWVIZOQVRIQF-APEMNGOPSA-N 50410405 CHEMBL2096726 Melanocortin receptor 4 Mus musculus 16700 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410405&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900706 163359429 CHEMBL2096726 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51001352 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(=O)N([C@@H](Cc2ccc(O)cc2)C(N)=O)C(C)(NC(=O)[C@H](Cc2ccccc2)NC1=O)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 InChI=1S/C67H83N19O16/c1-34-56(92)79-46(14-9-23-74-66(71)72)59(95)82-48(27-39-31-75-45-13-8-7-12-43(39)45)62(98)84-50(29-53(69)89)61(97)78-35(2)57(93)80-47(25-36-10-5-4-6-11-36)64(100)85-67(3,65(101)102)86(52(55(70)91)26-38-17-21-42(88)22-18-38)54(90)30-51(81-58(94)44(68)24-37-15-19-41(87)20-16-37)63(99)83-49(60(96)77-34)28-40-32-73-33-76-40/h4-8,10-13,15-22,31-35,44,46-52,75,87-88H,9,14,23-30,68H2,1-3H3,(H2,69,89)(H2,70,91)(H,73,76)(H,77,96)(H,78,97)(H,79,92)(H,80,93)(H,81,94)(H,82,95)(H,83,99)(H,84,98)(H,85,100)(H,101,102)(H4,71,72,74)/t34-,35-,44-,46-,47-,48-,49-,50-,51-,52-,67?/m0/s1 COQOIHHAVMFYQY-OFPYHVTASA-N 50410415 CHEMBL2096722 Melanocortin receptor 4 Mus musculus 14700 ChEMBL 10.1021/jm049010r 10.7270/Q2PR7WS4 15828845 Wilczynski, A; Wilson, KR; Scott, JW; Edison, AS; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50410415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50410415&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 91900715 163359439 CHEMBL2096722 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51008160 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 5.01 ChEMBL 10.1021/jm800291b 10.7270/Q2K64JZN 18800761 Proneth, B; Pogozheva, ID; Portillo, FP; Mosberg, HI; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51032909 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1 JDKLPDJLXHXHNV-MFVUMRCOSA-N 50184359 (3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexanoylamino)-9-benzyl-6-(3-guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18hexaaza-cyclotricosane-23-carboxylic acid amide::Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2::Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2::CHEMBL430239::MT-II::ebi_340792 Melanocortin receptor 4 Mus musculus 0.087000 ChEMBL 10.1021/jm010524p 10.7270/Q2KK9CHF 12086493 Holder, JR; Bauzo, RM; Xiang, Z; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184359&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 92432 104068740 CHEMBL430239 1323 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51033000 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36-,37-,38+,39-,40-,41-/m0/s1 JDKLPDJLXHXHNV-MFVUMRCOSA-N 50184359 (3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexanoylamino)-9-benzyl-6-(3-guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18hexaaza-cyclotricosane-23-carboxylic acid amide::Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2::Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2::CHEMBL430239::MT-II::ebi_340792 Melanocortin receptor 4 Mus musculus 0.087000 ChEMBL 10.1021/jm020296e 10.7270/Q2Q2410R 12477357 Holder, JR; Xiang, Z; Bauzo, RM; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50184359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50184359&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 92432 104068740 CHEMBL430239 1323 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686539 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.390000 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686540 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O InChI=1S/C49H63N15O9/c1-27-47(72)64-19-9-16-39(64)48(73)63-18-8-15-38(63)46(71)62-36(22-30-25-53-26-56-30)45(70)59-34(20-28-10-3-2-4-11-28)43(68)58-33(14-7-17-54-49(51)52)41(66)60-35(21-29-24-55-32-13-6-5-12-31(29)32)44(69)61-37(23-40(50)65)42(67)57-27/h2-6,10-13,24-27,33-39,55H,7-9,14-23H2,1H3,(H2,50,65)(H,53,56)(H,57,67)(H,58,68)(H,59,70)(H,60,66)(H,61,69)(H,62,71)(H4,51,52,54)/t27-,33-,34+,35-,36-,37-,38-,39+/m0/s1 SXDDAGOBGOKPJZ-KRQKQKCMSA-N 50232407 CHEMBL4096678 Melanocortin receptor 4 Mus musculus 29 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232407 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232407&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137656180 384226696 CHEMBL4096678 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686541 NC(=O)C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O InChI=1S/C46H58N14O8/c47-38(61)22-35-44(67)60-18-8-15-37(60)45(68)59-17-7-14-36(59)43(66)57-34(21-28-24-50-25-53-28)42(65)55-32(19-26-9-2-1-3-10-26)40(63)54-31(13-6-16-51-46(48)49)39(62)56-33(41(64)58-35)20-27-23-52-30-12-5-4-11-29(27)30/h1-5,9-12,23-25,31-37,52H,6-8,13-22H2,(H2,47,61)(H,50,53)(H,54,63)(H,55,65)(H,56,62)(H,57,66)(H,58,64)(H4,48,49,51)/t31-,32+,33-,34-,35-,36-,37+/m0/s1 WHLGWBGXVPRUTM-AVIQUFBTSA-N 50232408 CHEMBL4080169 Melanocortin receptor 4 Mus musculus 170 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232408 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232408&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137648053 384226697 CHEMBL4080169 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686542 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C57H72N16O9/c1-33-48(74)70-44(26-35-15-6-3-7-16-35)55(81)73-24-12-21-47(73)56(82)72-23-11-20-46(72)54(80)69-43(28-37-31-61-32-64-37)52(78)67-41(25-34-13-4-2-5-14-34)50(76)66-40(19-10-22-62-57(59)60)49(75)68-42(51(77)71-45(29-58)53(79)65-33)27-36-30-63-39-18-9-8-17-38(36)39/h2-9,13-18,30-33,40-47,63H,10-12,19-29,58H2,1H3,(H,61,64)(H,65,79)(H,66,76)(H,67,78)(H,68,75)(H,69,80)(H,70,74)(H,71,77)(H4,59,60,62)/t33-,40-,41+,42-,43-,44-,45-,46-,47+/m0/s1 QKYQDOVWDSQOGH-BESZUINWSA-N 50232409 CHEMBL4104402 Melanocortin receptor 4 Mus musculus 23 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232409 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232409&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137656489 384226698 CHEMBL4104402 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686546 NC[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O InChI=1S/C45H58N14O7/c46-22-35-43(65)59-18-8-15-37(59)44(66)58-17-7-14-36(58)42(64)56-34(21-28-24-49-25-52-28)41(63)54-32(19-26-9-2-1-3-10-26)39(61)53-31(13-6-16-50-45(47)48)38(60)55-33(40(62)57-35)20-27-23-51-30-12-5-4-11-29(27)30/h1-5,9-12,23-25,31-37,51H,6-8,13-22,46H2,(H,49,52)(H,53,61)(H,54,63)(H,55,60)(H,56,64)(H,57,62)(H4,47,48,50)/t31-,32+,33-,34-,35-,36-,37+/m0/s1 GOVQVQYWNAENDB-AVIQUFBTSA-N 50232410 CHEMBL4081092 Melanocortin receptor 4 Mus musculus 950 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232410 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232410&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137645483 384226699 CHEMBL4081092 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686547 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C52H65N13O9/c1-30-44(67)63-40(26-32-15-6-3-7-16-32)50(73)65-24-12-21-42(65)51(74)64-23-11-20-41(64)49(72)62-37(25-31-13-4-2-5-14-31)47(70)59-36(19-10-22-56-52(54)55)45(68)60-38(27-33-29-57-35-18-9-8-17-34(33)35)48(71)61-39(28-43(53)66)46(69)58-30/h2-9,13-18,29-30,36-42,57H,10-12,19-28H2,1H3,(H2,53,66)(H,58,69)(H,59,70)(H,60,68)(H,61,71)(H,62,72)(H,63,67)(H4,54,55,56)/t30-,36-,37+,38-,39-,40-,41-,42+/m0/s1 WNYDECDZDPMHTD-UEJDMFTASA-N 50232411 CHEMBL4088980 Melanocortin receptor 4 Mus musculus 130 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232411 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232411&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137644449 384226700 CHEMBL4088980 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686548 NC(=O)C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O InChI=1S/C40H51N11O7/c41-33(52)21-30-38(57)51-18-8-15-32(51)39(58)50-17-7-14-31(50)37(56)48-28(19-23-9-2-1-3-10-23)35(54)46-27(13-6-16-44-40(42)43)34(53)47-29(36(55)49-30)20-24-22-45-26-12-5-4-11-25(24)26/h1-5,9-12,22,27-32,45H,6-8,13-21H2,(H2,41,52)(H,46,54)(H,47,53)(H,48,56)(H,49,55)(H4,42,43,44)/t27-,28+,29-,30-,31-,32+/m0/s1 LUIJNLJSVYPYGD-AAWHSFAPSA-N 50232412 CHEMBL4085584 Melanocortin receptor 4 Mus musculus 1100 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232412 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232412&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137645898 384226701 CHEMBL4085584 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686549 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C51H65N13O8/c1-30-43(65)61-39(26-32-15-6-3-7-16-32)49(71)64-24-12-21-42(64)50(72)63-23-11-20-41(63)48(70)60-37(25-31-13-4-2-5-14-31)45(67)58-36(19-10-22-55-51(53)54)44(66)59-38(46(68)62-40(28-52)47(69)57-30)27-33-29-56-35-18-9-8-17-34(33)35/h2-9,13-18,29-30,36-42,56H,10-12,19-28,52H2,1H3,(H,57,69)(H,58,67)(H,59,66)(H,60,70)(H,61,65)(H,62,68)(H4,53,54,55)/t30-,36-,37+,38-,39-,40-,41-,42+/m0/s1 DCMCPTOMECWXCP-UEJDMFTASA-N 50232406 CHEMBL4071283 Melanocortin receptor 4 Mus musculus 100 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232406&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137638218 384226695 CHEMBL4071283 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686550 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O InChI=1S/C42H56N12O7/c1-24-40(60)54-19-9-16-34(54)41(61)53-18-8-15-33(53)39(59)51-30(20-25-10-3-2-4-11-25)36(56)49-29(14-7-17-46-42(44)45)35(55)50-31(37(57)52-32(22-43)38(58)48-24)21-26-23-47-28-13-6-5-12-27(26)28/h2-6,10-13,23-24,29-34,47H,7-9,14-22,43H2,1H3,(H,48,58)(H,49,56)(H,50,55)(H,51,59)(H,52,57)(H4,44,45,46)/t24-,29-,30+,31-,32-,33-,34+/m0/s1 AFKJOTFKRGZSHP-NRVYVHGTSA-N 50232413 CHEMBL4092082 Melanocortin receptor 4 Mus musculus 150 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232413 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232413&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137654884 384226702 CHEMBL4092082 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686720 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C58H72N16O10/c1-33-49(76)72-45(26-35-15-6-3-7-16-35)56(83)74-24-12-21-47(74)57(84)73-23-11-20-46(73)55(82)71-43(28-37-31-62-32-65-37)54(81)68-41(25-34-13-4-2-5-14-34)52(79)67-40(19-10-22-63-58(60)61)50(77)69-42(27-36-30-64-39-18-9-8-17-38(36)39)53(80)70-44(29-48(59)75)51(78)66-33/h2-9,13-18,30-33,40-47,64H,10-12,19-29H2,1H3,(H2,59,75)(H,62,65)(H,66,78)(H,67,79)(H,68,81)(H,69,77)(H,70,80)(H,71,82)(H,72,76)(H4,60,61,63)/t33-,40-,41+,42-,43-,44-,45-,46-,47+/m0/s1 GCKALZNYTZTPLF-BESZUINWSA-N 50232414 CHEMBL4069451 Melanocortin receptor 4 Mus musculus 1.4 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232414 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232414&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134466953 384226703 CHEMBL4069451 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686723 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O InChI=1S/C48H63N15O8/c1-27-46(70)63-19-9-16-39(63)47(71)62-18-8-15-38(62)45(69)60-36(22-30-25-52-26-55-30)43(67)58-34(20-28-10-3-2-4-11-28)41(65)57-33(14-7-17-53-48(50)51)40(64)59-35(42(66)61-37(23-49)44(68)56-27)21-29-24-54-32-13-6-5-12-31(29)32/h2-6,10-13,24-27,33-39,54H,7-9,14-23,49H2,1H3,(H,52,55)(H,56,68)(H,57,65)(H,58,67)(H,59,64)(H,60,69)(H,61,66)(H4,50,51,53)/t27-,33-,34+,35-,36-,37-,38-,39+/m0/s1 RVSZGGCTKCMMEU-KRQKQKCMSA-N 50232405 CHEMBL4099127 Melanocortin receptor 4 Mus musculus 1.6 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232405 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232405&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 134463477 384226694 CHEMBL4099127 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50686727 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O InChI=1S/C43H56N12O8/c1-24-41(62)55-19-9-16-34(55)42(63)54-18-8-15-33(54)40(61)53-30(20-25-10-3-2-4-11-25)38(59)50-29(14-7-17-47-43(45)46)36(57)51-31(21-26-23-48-28-13-6-5-12-27(26)28)39(60)52-32(22-35(44)56)37(58)49-24/h2-6,10-13,23-24,29-34,48H,7-9,14-22H2,1H3,(H2,44,56)(H,49,58)(H,50,59)(H,51,57)(H,52,60)(H,53,61)(H4,45,46,47)/t24-,29-,30+,31-,32-,33-,34+/m0/s1 GZAPESRDDBKQIW-NRVYVHGTSA-N 50232415 CHEMBL4103508 Melanocortin receptor 4 Mus musculus 420 ChEMBL 10.1021/acs.jmedchem.6b01707 10.7270/Q2R213MT 28045525 Ericson, MD; Freeman, KT; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232415 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232415&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137658252 384226704 CHEMBL4103508 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819611 C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O InChI=1S/C49H63N11O8/c1-30-41(61)53-31(2)42(62)58-38(29-34-19-10-5-11-20-34)47(67)60-26-14-23-40(60)48(68)59-25-13-22-39(59)46(66)55-35(21-12-24-52-49(50)51)43(63)56-37(28-33-17-8-4-9-18-33)45(65)57-36(44(64)54-30)27-32-15-6-3-7-16-32/h3-11,15-20,30-31,35-40H,12-14,21-29H2,1-2H3,(H,53,61)(H,54,64)(H,55,66)(H,56,63)(H,57,65)(H,58,62)(H4,50,51,52)/t30-,31-,35-,36-,37-,38-,39-,40+/m0/s1 JYXFUDLFIKACLQ-ZZIILLBDSA-N 50258944 CHEMBL4077783 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258944&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137650523 402361691 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819612 CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O InChI=1S/C51H67N11O8/c1-31(2)42-48(68)55-32(3)43(63)59-39(30-35-20-11-6-12-21-35)49(69)62-27-15-24-41(62)50(70)61-26-14-23-40(61)47(67)56-36(22-13-25-54-51(52)53)44(64)57-37(28-33-16-7-4-8-17-33)45(65)58-38(46(66)60-42)29-34-18-9-5-10-19-34/h4-12,16-21,31-32,36-42H,13-15,22-30H2,1-3H3,(H,55,68)(H,56,67)(H,57,64)(H,58,65)(H,59,63)(H,60,66)(H4,52,53,54)/t32-,36-,37-,38-,39-,40-,41+,42-/m0/s1 GJBATEAXPBKLPO-XXBPCZIFSA-N 50258945 CHEMBL4094419 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258945&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137654977 402361692 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819613 C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C55H67N11O8/c1-35-47(67)64-44(34-39-23-12-5-13-24-39)53(73)66-30-16-27-46(66)54(74)65-29-15-26-45(65)52(72)60-40(25-14-28-58-55(56)57)48(68)61-42(32-37-19-8-3-9-20-37)50(70)63-43(33-38-21-10-4-11-22-38)51(71)62-41(49(69)59-35)31-36-17-6-2-7-18-36/h2-13,17-24,35,40-46H,14-16,25-34H2,1H3,(H,59,69)(H,60,72)(H,61,68)(H,62,71)(H,63,70)(H,64,67)(H4,56,57,58)/t35-,40-,41-,42-,43-,44-,45-,46+/m0/s1 MJXDRBVFYGXJGE-MFFNYUHFSA-N 50258946 CHEMBL4089149 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258946&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137644456 402361693 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819614 NC(=O)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(O)=O)NC1=O InChI=1S/C52H66N12O11/c53-42(65)30-38-48(72)57-35(22-23-43(66)67)45(69)62-39(29-33-17-8-3-9-18-33)50(74)64-26-12-21-41(64)51(75)63-25-11-20-40(63)49(73)58-34(19-10-24-56-52(54)55)44(68)59-36(27-31-13-4-1-5-14-31)46(70)60-37(47(71)61-38)28-32-15-6-2-7-16-32/h1-9,13-18,34-41H,10-12,19-30H2,(H2,53,65)(H,57,72)(H,58,73)(H,59,68)(H,60,70)(H,61,71)(H,62,69)(H,66,67)(H4,54,55,56)/t34-,35-,36-,37-,38-,39-,40-,41+/m0/s1 BBNQOJOJVRXODK-JTPPURIGSA-N 50258947 CHEMBL4078828 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258947&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137649844 402361694 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819615 NCCCC[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C53H71N13O9/c54-25-11-10-21-36-46(69)64-41(31-35-19-8-3-9-20-35)51(74)66-28-14-24-43(66)52(75)65-27-13-23-42(65)50(73)60-37(22-12-26-58-53(56)57)45(68)61-38(29-33-15-4-1-5-16-33)47(70)62-39(30-34-17-6-2-7-18-34)48(71)63-40(32-44(55)67)49(72)59-36/h1-9,15-20,36-43H,10-14,21-32,54H2,(H2,55,67)(H,59,72)(H,60,73)(H,61,68)(H,62,70)(H,63,71)(H,64,69)(H4,56,57,58)/t36-,37-,38-,39-,40-,41-,42-,43+/m0/s1 FLXFHOMVCUNYHP-KXEQMSFWSA-N 50258948 CHEMBL4093505 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258948&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137654466 402361695 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819616 NC(=O)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O InChI=1S/C53H66N14O9/c54-44(68)29-40-49(73)63-39(28-35-30-57-31-59-35)48(72)65-41(27-34-17-8-3-9-18-34)51(75)67-24-12-21-43(67)52(76)66-23-11-20-42(66)50(74)60-36(19-10-22-58-53(55)56)45(69)61-37(25-32-13-4-1-5-14-32)46(70)62-38(47(71)64-40)26-33-15-6-2-7-16-33/h1-9,13-18,30-31,36-43H,10-12,19-29H2,(H2,54,68)(H,57,59)(H,60,74)(H,61,69)(H,62,70)(H,63,73)(H,64,71)(H,65,72)(H4,55,56,58)/t36-,37-,38-,39-,40-,41-,42-,43+/m0/s1 FZCYFFOFHSYNET-KXEQMSFWSA-N 50258949 CHEMBL4072797 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258949&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137640194 402361696 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819617 NC(=O)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)CNC1=O InChI=1S/C49H62N12O9/c50-40(62)28-36-42(64)54-29-41(63)55-37(27-32-17-8-3-9-18-32)47(69)61-24-12-21-39(61)48(70)60-23-11-20-38(60)46(68)56-33(19-10-22-53-49(51)52)43(65)57-34(25-30-13-4-1-5-14-30)44(66)58-35(45(67)59-36)26-31-15-6-2-7-16-31/h1-9,13-18,33-39H,10-12,19-29H2,(H2,50,62)(H,54,64)(H,55,63)(H,56,68)(H,57,65)(H,58,66)(H,59,67)(H4,51,52,53)/t33-,34-,35-,36-,37-,38-,39+/m0/s1 LCTCEVLNIRAIKH-IOQDMCFNSA-N 50258951 CHEMBL4066514 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258951&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137631703 402361697 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819618 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](C)NC1=O InChI=1S/C44H60N12O9/c1-25-36(58)50-26(2)42(64)56-21-11-18-34(56)43(65)55-20-10-17-33(55)41(63)51-29(16-9-19-48-44(46)47)37(59)52-30(22-27-12-5-3-6-13-27)39(61)53-31(23-28-14-7-4-8-15-28)40(62)54-32(24-35(45)57)38(60)49-25/h3-8,12-15,25-26,29-34H,9-11,16-24H2,1-2H3,(H2,45,57)(H,49,60)(H,50,58)(H,51,63)(H,52,59)(H,53,61)(H,54,62)(H4,46,47,48)/t25-,26-,29-,30-,31-,32-,33-,34+/m0/s1 LPRUCOCZSJHJNR-OAYFZSQUSA-N 50258952 CHEMBL4065443 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258952&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137632217 402361698 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819829 CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O InChI=1S/C52H69N11O8/c1-32(2)28-38-46(66)56-33(3)44(64)61-41(31-36-20-11-6-12-21-36)50(70)63-27-15-24-43(63)51(71)62-26-14-23-42(62)49(69)57-37(22-13-25-55-52(53)54)45(65)59-39(29-34-16-7-4-8-17-34)48(68)60-40(47(67)58-38)30-35-18-9-5-10-19-35/h4-12,16-21,32-33,37-43H,13-15,22-31H2,1-3H3,(H,56,66)(H,57,69)(H,58,67)(H,59,65)(H,60,68)(H,61,64)(H4,53,54,55)/t33-,37-,38-,39-,40-,41-,42-,43+/m0/s1 SLCMUVLWXWASLE-LVXPXGLXSA-N 50258957 CHEMBL4066929 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258957&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137631920 402361703 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819837 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O InChI=1S/C52H69N11O8/c1-3-4-23-37-45(65)56-33(2)44(64)61-41(32-36-21-12-7-13-22-36)50(70)63-29-16-26-43(63)51(71)62-28-15-25-42(62)49(69)58-38(24-14-27-55-52(53)54)46(66)59-40(31-35-19-10-6-11-20-35)48(68)60-39(47(67)57-37)30-34-17-8-5-9-18-34/h5-13,17-22,33,37-43H,3-4,14-16,23-32H2,1-2H3,(H,56,65)(H,57,67)(H,58,69)(H,59,66)(H,60,68)(H,61,64)(H4,53,54,55)/t33-,37-,38-,39-,40-,41-,42-,43+/m0/s1 SXSUHWZPZOJQGS-LVXPXGLXSA-N 50258953 CHEMBL4086679 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258953&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137641768 402361699 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819838 C[C@@H]1NC(=O)[C@@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O8/c1-30-41(62)58-37(28-33-18-9-4-10-19-33)47(68)61-25-13-22-40(61)48(69)60-24-12-21-39(60)46(67)55-34(20-11-23-53-49(51)52)42(63)56-35(26-31-14-5-2-6-15-31)43(64)57-36(27-32-16-7-3-8-17-32)44(65)59-38(29-50)45(66)54-30/h2-10,14-19,30,34-40H,11-13,20-29,50H2,1H3,(H,54,66)(H,55,67)(H,56,63)(H,57,64)(H,58,62)(H,59,65)(H4,51,52,53)/t30-,34-,35-,36-,37-,38+,39-,40+/m0/s1 IJUWOYISGCBYSL-CDEFTACNSA-N 50258963 CHEMBL4071633 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258963 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258963&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137638391 402361709 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819843 C[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C51H65N11O10/c1-31-43(65)60-39(30-34-18-9-4-10-19-34)49(71)62-27-13-22-41(62)50(72)61-26-12-21-40(61)48(70)57-35(20-11-25-54-51(52)53)45(67)58-38(29-33-16-7-3-8-17-33)47(69)59-37(28-32-14-5-2-6-15-32)46(68)56-36(44(66)55-31)23-24-42(63)64/h2-10,14-19,31,35-41H,11-13,20-30H2,1H3,(H,55,66)(H,56,68)(H,57,70)(H,58,67)(H,59,69)(H,60,65)(H,63,64)(H4,52,53,54)/t31-,35-,36-,37-,38-,39-,40-,41+/m0/s1 NMIKIOBZRLWTII-ASFXGQTKSA-N 50258959 CHEMBL4098651 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258959 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258959&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137662060 402361705 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819851 C[C@@H]1NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H63N11O10/c1-30-42(64)59-38(28-33-18-9-4-10-19-33)48(70)61-25-13-22-40(61)49(71)60-24-12-21-39(60)47(69)55-34(20-11-23-53-50(51)52)43(65)56-35(26-31-14-5-2-6-15-31)45(67)57-36(27-32-16-7-3-8-17-32)46(68)58-37(29-41(62)63)44(66)54-30/h2-10,14-19,30,34-40H,11-13,20-29H2,1H3,(H,54,66)(H,55,69)(H,56,65)(H,57,67)(H,58,68)(H,59,64)(H,62,63)(H4,51,52,53)/t30-,34-,35-,36-,37-,38-,39-,40+/m0/s1 MVUJMDFBDCYDDH-GNDHHEKASA-N 50258960 CHEMBL4093379 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258960 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258960&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137653029 402361706 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819852 C[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H63N11O9/c1-30-41(62)57-37(28-33-18-9-4-10-19-33)47(68)60-25-13-22-40(60)48(69)59-24-12-21-39(59)46(67)54-34(20-11-23-52-49(50)51)42(63)55-35(26-31-14-5-2-6-15-31)43(64)56-36(27-32-16-7-3-8-17-32)44(65)58-38(29-61)45(66)53-30/h2-10,14-19,30,34-40,61H,11-13,20-29H2,1H3,(H,53,66)(H,54,67)(H,55,63)(H,56,64)(H,57,62)(H,58,65)(H4,50,51,52)/t30-,34-,35-,36-,37-,38-,39-,40+/m0/s1 ZUJZDYCGJDKQJV-GNDHHEKASA-N 50258961 CHEMBL4101128 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258961&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137659851 402361707 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819853 CCC1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O InChI=1S/C50H65N11O8/c1-3-35-43(63)54-31(2)42(62)59-39(30-34-20-11-6-12-21-34)48(68)61-27-15-24-41(61)49(69)60-26-14-23-40(60)47(67)56-36(22-13-25-53-50(51)52)44(64)57-38(29-33-18-9-5-10-19-33)46(66)58-37(45(65)55-35)28-32-16-7-4-8-17-32/h4-12,16-21,31,35-41H,3,13-15,22-30H2,1-2H3,(H,54,63)(H,55,65)(H,56,67)(H,57,64)(H,58,66)(H,59,62)(H4,51,52,53)/t31-,35?,36-,37-,38-,39-,40-,41+/m0/s1 YYFWQUJHYRDEFR-GTCRZPLGSA-N 50258962 CHEMBL4083137 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258962&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137645343 402361708 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819854 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H64N12O9/c1-30-42(64)60-38(28-33-18-9-4-10-19-33)48(70)62-25-13-22-40(62)49(71)61-24-12-21-39(61)47(69)56-34(20-11-23-54-50(52)53)43(65)57-35(26-31-14-5-2-6-15-31)45(67)58-36(27-32-16-7-3-8-17-32)46(68)59-37(29-41(51)63)44(66)55-30/h2-10,14-19,30,34-40H,11-13,20-29H2,1H3,(H2,51,63)(H,55,66)(H,56,69)(H,57,65)(H,58,67)(H,59,68)(H,60,64)(H4,52,53,54)/t30-,34-,35-,36-,37-,38-,39-,40+/m0/s1 MTKQTEXYJKPBQD-GNDHHEKASA-N 50089398 CHEMBL3577981 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089398&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178151 103988187 CHEMBL3577981 ZINC26489473 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819869 C[C@@H]1NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC1=O InChI=1S/C38H53N11O9S2/c1-21-31(52)48-28(19-59)37(58)49-29(20-60)36(57)45-24(13-8-14-41-38(39)40)33(54)47-26(16-23-11-6-3-7-12-23)34(55)46-25(15-22-9-4-2-5-10-22)32(53)42-17-30(51)44-27(18-50)35(56)43-21/h2-7,9-12,21,24-29,50,59-60H,8,13-20H2,1H3,(H,42,53)(H,43,56)(H,44,51)(H,45,57)(H,46,55)(H,47,54)(H,48,52)(H,49,58)(H4,39,40,41)/t21-,24-,25-,26-,27-,28-,29-/m0/s1 PQOVOLYOYBBMRV-VNPODFCCSA-N 50258943 CHEMBL4060087 Melanocortin receptor 4 Mus musculus 54 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258943 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258943&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137637711 402361690 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819870 C[C@@H]1NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C52H65N13O8/c1-32-44(66)63-41(28-35-18-9-4-10-19-35)50(72)65-25-13-22-43(65)51(73)64-24-12-21-42(64)49(71)59-37(20-11-23-56-52(53)54)45(67)60-38(26-33-14-5-2-6-15-33)47(69)61-39(27-34-16-7-3-8-17-34)48(70)62-40(46(68)58-32)29-36-30-55-31-57-36/h2-10,14-19,30-32,37-43H,11-13,20-29H2,1H3,(H,55,57)(H,58,68)(H,59,71)(H,60,67)(H,61,69)(H,62,70)(H,63,66)(H4,53,54,56)/t32-,37-,38-,39-,40-,41-,42-,43+/m0/s1 GRZFFQDNONUZFL-MGYOIZNYSA-N 50258958 CHEMBL4104582 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258958&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137656661 402361704 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819871 C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O InChI=1S/C50H65N11O9/c1-30-42(63)58-38(29-34-19-10-5-11-20-34)48(69)61-26-14-23-40(61)49(70)60-25-13-22-39(60)46(67)55-35(21-12-24-53-50(51)52)43(64)56-36(27-32-15-6-3-7-16-32)44(65)57-37(28-33-17-8-4-9-18-33)45(66)59-41(31(2)62)47(68)54-30/h3-11,15-20,30-31,35-41,62H,12-14,21-29H2,1-2H3,(H,54,68)(H,55,67)(H,56,64)(H,57,65)(H,58,63)(H,59,66)(H4,51,52,53)/t30-,31+,35-,36-,37-,38-,39-,40+,41-/m0/s1 VEFOOJXXEWBHRI-BRWQPZTMSA-N 50258964 CHEMBL4072662 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258964 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258964&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137639030 402361710 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819874 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O8/c1-30-41(62)58-37(28-33-18-9-4-10-19-33)47(68)61-25-13-22-40(61)48(69)60-24-12-21-39(60)46(67)55-34(20-11-23-53-49(51)52)42(63)56-35(26-31-14-5-2-6-15-31)43(64)57-36(27-32-16-7-3-8-17-32)44(65)59-38(29-50)45(66)54-30/h2-10,14-19,30,34-40H,11-13,20-29,50H2,1H3,(H,54,66)(H,55,67)(H,56,63)(H,57,64)(H,58,62)(H,59,65)(H4,51,52,53)/t30-,34-,35-,36-,37-,38-,39-,40+/m0/s1 IJUWOYISGCBYSL-GNDHHEKASA-N 50258965 CHEMBL4102048 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258965&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 132938008 402361711 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819895 NC(=O)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(O)=O)NC1=O InChI=1S/C51H64N12O11/c52-41(64)28-36-46(70)60-37(29-42(65)66)47(71)61-38(27-32-17-8-3-9-18-32)49(73)63-24-12-21-40(63)50(74)62-23-11-20-39(62)48(72)56-33(19-10-22-55-51(53)54)43(67)57-34(25-30-13-4-1-5-14-30)44(68)58-35(45(69)59-36)26-31-15-6-2-7-16-31/h1-9,13-18,33-40H,10-12,19-29H2,(H2,52,64)(H,56,72)(H,57,67)(H,58,68)(H,59,69)(H,60,70)(H,61,71)(H,65,66)(H4,53,54,55)/t33-,34-,35-,36-,37-,38-,39-,40+/m0/s1 QKSRATZDAIWTOV-ZHECQJHESA-N 50258956 CHEMBL4096856 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258956&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137653646 402361702 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819898 NC(=O)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC1=O InChI=1S/C50H64N12O10/c51-41(64)28-36-45(68)60-38(29-63)46(69)59-37(27-32-17-8-3-9-18-32)48(71)62-24-12-21-40(62)49(72)61-23-11-20-39(61)47(70)55-33(19-10-22-54-50(52)53)42(65)56-34(25-30-13-4-1-5-14-30)43(66)57-35(44(67)58-36)26-31-15-6-2-7-16-31/h1-9,13-18,33-40,63H,10-12,19-29H2,(H2,51,64)(H,55,70)(H,56,65)(H,57,66)(H,58,67)(H,59,69)(H,60,68)(H4,52,53,54)/t33-,34-,35-,36-,37-,38-,39-,40+/m0/s1 QDVDTASXZDDPJL-ZHECQJHESA-N 50258955 CHEMBL4075125 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258955&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137649684 402361701 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50819905 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.410000 ChEMBL 10.1021/acs.jmedchem.7b00856 10.7270/Q2DN47H1 28813605 Ericson, MD; Freeman, KT; Schnell, SM; Fleming, KA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50866240 CC(C)C[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(N)=O 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UVSHDNWWLSZUKJ-XDJLRNHBSA-N 50263393 CHEMBL4072638 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.8b00251 10.7270/Q2CV4M69 29578343 Ericson, MD; Singh, A; Tala, SR; Haslach, EM; Dirain, MLS; Schaub, JW; Flores, V; Eick, N; Lensing, CJ; Freeman, KT; Smeester, BA; Adank, DN; Wilber, SL; Speth, R; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263393 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263393&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137639140 404341472 C02248 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50866241 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](N)CC(O)=O)C(C)C)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(N)=O InChI=1S/C167H263N49O49S6/c1-13-83(7)131(162(261)194-103(48-50-122(173)225)140(239)184-70-128(231)211-133(87(11)220)164(263)209-118(77-269)157(256)199-106(60-90-36-42-94(222)43-37-90)147(246)192-99(34-26-56-180-167(177)178)139(238)183-69-127(230)188-100(31-19-23-53-169)142(241)186-85(9)136(235)191-101(32-20-24-54-170)143(242)205-117(76-268)158(257)208-115(74-266)155(254)190-98(135(176)234)30-18-22-52-168)213-145(244)102(33-21-25-55-171)193-165(264)134(88(12)221)215-152(251)109(59-89-28-16-15-17-29-89)201-163(262)132(84(8)14-2)214-160(259)121-35-27-57-216(121)166(265)120(79-271)210-137(236)86(10)187-153(252)113(72-218)203-149(248)108(62-92-40-46-96(224)47-41-92)197-146(245)105(58-81(3)4)196-156(255)116(75-267)206-144(243)104(49-51-123(174)226)189-126(229)68-181-125(228)67-182-141(240)112(71-217)202-154(253)114(73-219)204-161(260)130(82(5)6)212-159(258)119(78-270)207-151(250)111(65-124(175)227)200-148(247)107(61-91-38-44-95(223)45-39-91)198-150(249)110(63-93-66-179-80-185-93)195-138(237)97(172)64-129(232)233/h15-17,28-29,36-47,66,80-88,97-121,130-134,217-224,266-271H,13-14,18-27,30-35,48-65,67-79,168-172H2,1-12H3,(H2,173,225)(H2,174,226)(H2,175,227)(H2,176,234)(H,179,185)(H,181,228)(H,182,240)(H,183,238)(H,184,239)(H,186,241)(H,187,252)(H,188,230)(H,189,229)(H,190,254)(H,191,235)(H,192,246)(H,193,264)(H,194,261)(H,195,237)(H,196,255)(H,197,245)(H,198,249)(H,199,256)(H,200,247)(H,201,262)(H,202,253)(H,203,248)(H,204,260)(H,205,242)(H,206,243)(H,207,250)(H,208,257)(H,209,263)(H,210,236)(H,211,231)(H,212,258)(H,213,244)(H,214,259)(H,215,251)(H,232,233)(H4,177,178,180)/t83-,84-,85-,86-,87+,88+,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,130-,131-,132-,133-,134-/m0/s1 BLXHAQUKQLQYMY-YYSGPKNVSA-N 50263383 CHEMBL4079142 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.8b00251 10.7270/Q2CV4M69 29578343 Ericson, MD; Singh, A; Tala, SR; Haslach, EM; Dirain, MLS; Schaub, JW; Flores, V; Eick, N; Lensing, CJ; Freeman, KT; Smeester, BA; Adank, DN; Wilber, SL; Speth, R; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263383&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137651025 404341471 C02248 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50866450 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.870000 ChEMBL 10.1021/acs.jmedchem.8b00251 10.7270/Q2CV4M69 29578343 Ericson, MD; Singh, A; Tala, SR; Haslach, EM; Dirain, MLS; Schaub, JW; Flores, V; Eick, N; Lensing, CJ; Freeman, KT; Smeester, BA; Adank, DN; Wilber, SL; Speth, R; Haskell-Luevano, C University of Florida http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886973 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C33H41IN10O5/c1-19(45)41-26(15-24-16-38-18-40-24)31(48)42-25(7-4-12-39-33(36)37)30(47)43-27(13-20-8-10-23(34)11-9-20)32(49)44-17-22-6-3-2-5-21(22)14-28(44)29(35)46/h2-3,5-6,8-11,16,18,25-28H,4,7,12-15,17H2,1H3,(H2,35,46)(H,38,40)(H,41,45)(H,42,48)(H,43,47)(H4,36,37,39)/t25-,26-,27+,28-/m0/s1 ZMBJSZYTIJFURY-BPXGVECKSA-N 50266696 CHEMBL4063911 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266696&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 132180597 404858126 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886974 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O InChI=1S/C42H47IN8O5/c1-26(52)51-25-32-11-6-5-10-31(32)24-37(51)41(56)48-34(12-7-21-47-42(45)46)39(54)50-36(23-28-15-19-33(43)20-16-28)40(55)49-35(38(44)53)22-27-13-17-30(18-14-27)29-8-3-2-4-9-29/h2-6,8-11,13-20,34-37H,7,12,21-25H2,1H3,(H2,44,53)(H,48,56)(H,49,55)(H,50,54)(H4,45,46,47)/t34-,35-,36+,37-/m0/s1 SVFOBYVGCNKSJK-FBBJYXRJSA-N 50266697 CHEMBL4100584 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266697 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266697&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137661461 404858127 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886975 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O InChI=1S/C41H47IN8O5/c1-26(51)47-35(24-27-9-4-2-5-10-27)39(54)48-33(13-8-22-46-41(44)45)38(53)50-36(25-29-16-20-32(42)21-17-29)40(55)49-34(37(43)52)23-28-14-18-31(19-15-28)30-11-6-3-7-12-30/h2-7,9-12,14-21,33-36H,8,13,22-25H2,1H3,(H2,43,52)(H,47,51)(H,48,54)(H,49,55)(H,50,53)(H4,44,45,46)/t33-,34-,35-,36+/m0/s1 ZYEHBONEFWSELV-SKXFTCKDSA-N 50266698 CHEMBL4073782 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266698 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266698&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137641005 404858128 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886976 CC(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O InChI=1S/C43H47IN8O5S/c1-26(53)49-36(22-27-13-17-30(18-14-27)29-8-3-2-4-9-29)41(56)50-34(11-7-21-48-43(46)47)40(55)52-37(23-28-15-19-32(44)20-16-28)42(57)51-35(39(45)54)24-31-25-58-38-12-6-5-10-33(31)38/h2-6,8-10,12-20,25,34-37H,7,11,21-24H2,1H3,(H2,45,54)(H,49,53)(H,50,56)(H,51,57)(H,52,55)(H4,46,47,48)/t34-,35-,36-,37+/m0/s1 RCORIQNPILXJRC-MYOMABOUSA-N 50266699 CHEMBL4103985 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266699&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137657206 404858129 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886977 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O InChI=1S/C39H43IN8O5S2/c1-22(49)45-32(19-25-21-55-34-11-5-3-8-28(25)34)38(53)46-29(9-6-16-44-39(42)43)36(51)48-31(17-23-12-14-26(40)15-13-23)37(52)47-30(35(41)50)18-24-20-54-33-10-4-2-7-27(24)33/h2-5,7-8,10-15,20-21,29-32H,6,9,16-19H2,1H3,(H2,41,50)(H,45,49)(H,46,53)(H,47,52)(H,48,51)(H4,42,43,44)/t29-,30-,31+,32-/m0/s1 VVHOGOJXZCVGIT-IHZBLBIESA-N 50266700 CHEMBL4079721 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266700 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266700&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137649203 404858130 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886978 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O InChI=1S/C38H43IN8O5S/c1-22(48)47-20-25-8-3-2-7-24(25)19-32(47)37(52)44-29(10-6-16-43-38(41)42)35(50)46-31(17-23-12-14-27(39)15-13-23)36(51)45-30(34(40)49)18-26-21-53-33-11-5-4-9-28(26)33/h2-5,7-9,11-15,21,29-32H,6,10,16-20H2,1H3,(H2,40,49)(H,44,52)(H,45,51)(H,46,50)(H4,41,42,43)/t29-,30-,31+,32-/m0/s1 NHYVGDCZYBIGJH-IHZBLBIESA-N 50266701 CHEMBL4064728 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266701&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137636060 404858131 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886979 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O InChI=1S/C41H45IN8O5S/c1-24(51)47-34(21-26-12-15-27-7-2-3-8-28(27)19-26)39(54)48-32(10-6-18-46-41(44)45)38(53)50-35(20-25-13-16-30(42)17-14-25)40(55)49-33(37(43)52)22-29-23-56-36-11-5-4-9-31(29)36/h2-5,7-9,11-17,19,23,32-35H,6,10,18,20-22H2,1H3,(H2,43,52)(H,47,51)(H,48,54)(H,49,55)(H,50,53)(H4,44,45,46)/t32-,33-,34-,35+/m0/s1 QOKVJCWRNJMDNT-AYXCPNKJSA-N 50266702 CHEMBL4102613 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266702 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266702&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137657151 104113926 29067 ZINC05884094 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886980 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C33H46IN11O5/c1-19(46)42-24(8-4-14-40-32(36)37)29(48)43-25(9-5-15-41-33(38)39)30(49)44-26(16-20-10-12-23(34)13-11-20)31(50)45-18-22-7-3-2-6-21(22)17-27(45)28(35)47/h2-3,6-7,10-13,24-27H,4-5,8-9,14-18H2,1H3,(H2,35,47)(H,42,46)(H,43,48)(H,44,49)(H4,36,37,40)(H4,38,39,41)/t24-,25-,26+,27-/m0/s1 GYPFKQQJLPOFKF-NFGXINMFSA-N 50266704 CHEMBL4083717 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266704&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search PLP 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132180598 104113928 597326 ZINC01532514 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886981 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C36H43IN8O5/c1-22(46)42-29(18-23-8-3-2-4-9-23)34(49)43-28(12-7-17-41-36(39)40)33(48)44-30(19-24-13-15-27(37)16-14-24)35(50)45-21-26-11-6-5-10-25(26)20-31(45)32(38)47/h2-6,8-11,13-16,28-31H,7,12,17-21H2,1H3,(H2,38,47)(H,42,46)(H,43,49)(H,44,48)(H4,39,40,41)/t28-,29-,30+,31-/m0/s1 QPTLNEZUBQIIOA-MBEDZMRZSA-N 50266706 CHEMBL4079298 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266706&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137651071 104113930 29067 ZINC14944679 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886982 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C32H46IN11O5/c1-19(45)41-23(9-5-15-39-31(35)36)28(47)42-24(10-6-16-40-32(37)38)29(48)44-26(18-21-11-13-22(33)14-12-21)30(49)43-25(27(34)46)17-20-7-3-2-4-8-20/h2-4,7-8,11-14,23-26H,5-6,9-10,15-18H2,1H3,(H2,34,46)(H,41,45)(H,42,47)(H,43,49)(H,44,48)(H4,35,36,39)(H4,37,38,40)/t23-,24-,25-,26+/m0/s1 NVDGFOWDLBIVFD-ASDGIDEWSA-N 50266708 CHEMBL4102774 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266708&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137658359 104113932 75323 ZINC05225520 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886983 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C32H41IN10O5/c1-19(44)40-27(16-23-17-37-18-39-23)31(48)41-24(8-5-13-38-32(35)36)29(46)43-26(15-21-9-11-22(33)12-10-21)30(47)42-25(28(34)45)14-20-6-3-2-4-7-20/h2-4,6-7,9-12,17-18,24-27H,5,8,13-16H2,1H3,(H2,34,45)(H,37,39)(H,40,44)(H,41,48)(H,42,47)(H,43,46)(H4,35,36,38)/t24-,25-,26+,27-/m0/s1 VCDHNQMKKAXJMF-NFGXINMFSA-N 50266709 CHEMBL4086346 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266709&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137642664 404858132 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886984 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C37H43IN8O5S/c1-22(47)43-31(20-25-21-52-32-12-6-5-10-27(25)32)36(51)44-28(11-7-17-42-37(40)41)34(49)46-30(19-24-13-15-26(38)16-14-24)35(50)45-29(33(39)48)18-23-8-3-2-4-9-23/h2-6,8-10,12-16,21,28-31H,7,11,17-20H2,1H3,(H2,39,48)(H,43,47)(H,44,51)(H,45,50)(H,46,49)(H4,40,41,42)/t28-,29-,30+,31-/m0/s1 HUEGLXHQBOKBRC-MBEDZMRZSA-N 50266710 CHEMBL4094121 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266710 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266710&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137654273 404858133 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886985 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C36H43IN8O5/c1-22(46)45-21-26-11-6-5-10-25(26)20-31(45)35(50)42-28(12-7-17-41-36(39)40)33(48)44-30(19-24-13-15-27(37)16-14-24)34(49)43-29(32(38)47)18-23-8-3-2-4-9-23/h2-6,8-11,13-16,28-31H,7,12,17-21H2,1H3,(H2,38,47)(H,42,50)(H,43,49)(H,44,48)(H4,39,40,41)/t28-,29-,30+,31-/m0/s1 OFASMVGSYQYDEN-MBEDZMRZSA-N 50266711 CHEMBL4073480 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266711&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137640434 404858134 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886986 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C39H45IN8O5/c1-24(49)45-33(23-27-13-16-28-10-5-6-11-29(28)20-27)37(52)46-31(12-7-19-44-39(42)43)36(51)48-34(22-26-14-17-30(40)18-15-26)38(53)47-32(35(41)50)21-25-8-3-2-4-9-25/h2-6,8-11,13-18,20,31-34H,7,12,19,21-23H2,1H3,(H2,41,50)(H,45,49)(H,46,52)(H,47,53)(H,48,51)(H4,42,43,44)/t31-,32-,33-,34+/m0/s1 RWTGFQZJEQFICN-GZXHTMMISA-N 50266712 CHEMBL4083857 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266712&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137647508 404858135 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886987 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C39H45IN8O5/c1-24(49)45-33(23-27-13-16-28-10-5-6-11-29(28)20-27)37(52)46-31(12-7-19-44-39(42)43)36(51)48-34(22-26-14-17-30(40)18-15-26)38(53)47-32(35(41)50)21-25-8-3-2-4-9-25/h2-6,8-11,13-18,20,31-34H,7,12,19,21-23H2,1H3,(H2,41,50)(H,45,49)(H,46,52)(H,47,53)(H,48,51)(H4,42,43,44)/t31-,32-,33+,34+/m0/s1 RWTGFQZJEQFICN-PSWJWLENSA-N 50266713 CHEMBL4089759 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266713&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137642804 404858136 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886988 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C36H48IN11O5/c1-21(49)45-27(8-4-16-43-35(39)40)32(51)46-28(9-5-17-44-36(41)42)33(52)48-30(19-22-11-14-26(37)15-12-22)34(53)47-29(31(38)50)20-23-10-13-24-6-2-3-7-25(24)18-23/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,50)(H,45,49)(H,46,51)(H,47,53)(H,48,52)(H4,39,40,43)(H4,41,42,44)/t27-,28-,29-,30+/m0/s1 VLHRNMSUNLFBOW-GCXHJFECSA-N 50266714 CHEMBL4068643 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266714 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266714&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137632948 404858137 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886989 CC(=O)N[C@@H](Cc1csc2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C41H45IN8O5S/c1-24(51)47-35(22-29-23-56-36-11-5-4-9-31(29)36)40(55)48-32(10-6-18-46-41(44)45)38(53)50-34(20-25-13-16-30(42)17-14-25)39(54)49-33(37(43)52)21-26-12-15-27-7-2-3-8-28(27)19-26/h2-5,7-9,11-17,19,23,32-35H,6,10,18,20-22H2,1H3,(H2,43,52)(H,47,51)(H,48,55)(H,49,54)(H,50,53)(H4,44,45,46)/t32-,33-,34+,35-/m0/s1 PBPXEAHPKCTEAW-KMSCUOMXSA-N 50266715 CHEMBL4069415 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266715&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137632016 404858138 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886990 CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C40H45IN8O5/c1-24(50)49-23-30-10-5-4-9-29(30)22-35(49)39(54)46-32(11-6-18-45-40(43)44)37(52)48-34(20-25-13-16-31(41)17-14-25)38(53)47-33(36(42)51)21-26-12-15-27-7-2-3-8-28(27)19-26/h2-5,7-10,12-17,19,32-35H,6,11,18,20-23H2,1H3,(H2,42,51)(H,46,54)(H,47,53)(H,48,52)(H4,43,44,45)/t32-,33-,34+,35-/m0/s1 CIFUBNJEFZRCAW-KMSCUOMXSA-N 50266716 CHEMBL4090448 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266716&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137643799 404858139 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886991 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C43H47IN8O5/c1-26(53)49-37(25-29-13-17-31-8-3-5-10-33(31)22-29)41(56)50-35(11-6-20-48-43(46)47)40(55)52-38(23-27-14-18-34(44)19-15-27)42(57)51-36(39(45)54)24-28-12-16-30-7-2-4-9-32(30)21-28/h2-5,7-10,12-19,21-22,35-38H,6,11,20,23-25H2,1H3,(H2,45,54)(H,49,53)(H,50,56)(H,51,57)(H,52,55)(H4,46,47,48)/t35-,36-,37-,38+/m0/s1 OUNKXHZNGYZMNG-IZBQCXFTSA-N 50266717 CHEMBL4082615 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266717&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137645549 404858140 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886992 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C36H48IN11O5/c1-21(49)45-27(8-4-16-43-35(39)40)32(51)46-28(9-5-17-44-36(41)42)33(52)48-30(19-22-11-14-26(37)15-12-22)34(53)47-29(31(38)50)20-23-10-13-24-6-2-3-7-25(24)18-23/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,50)(H,45,49)(H,46,51)(H,47,53)(H,48,52)(H4,39,40,43)(H4,41,42,44)/t27-,28-,29+,30+/m0/s1 VLHRNMSUNLFBOW-VZNYXHRGSA-N 50266722 CHEMBL4072129 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266722&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 132180599 404858141 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50886993 CC(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C45H49IN8O5/c1-28(55)51-39(25-29-13-18-34(19-14-29)32-8-3-2-4-9-32)43(58)52-37(12-7-23-50-45(48)49)42(57)54-40(26-30-16-21-36(46)22-17-30)44(59)53-38(41(47)56)27-31-15-20-33-10-5-6-11-35(33)24-31/h2-6,8-11,13-22,24,37-40H,7,12,23,25-27H2,1H3,(H2,47,56)(H,51,55)(H,52,58)(H,53,59)(H,54,57)(H4,48,49,50)/t37-,38+,39-,40+/m0/s1 PGSXLPDELYOSBW-QYPPMKSWSA-N 50266723 CHEMBL4087093 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266723&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137644114 404858142 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887014 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C76H110N20O19/c1-5-6-21-50(88-73(113)59(41-98)94-70(110)56(36-47-25-27-49(100)28-26-47)92-72(112)58(40-97)85-44(4)99)66(106)89-52(29-30-62(102)103)68(108)93-57(37-48-38-81-42-84-48)71(111)87-51(23-15-32-82-76(79)80)67(107)91-55(35-46-19-11-8-12-20-46)69(109)90-54(34-45-17-9-7-10-18-45)65(105)83-39-61(101)86-53(22-13-14-31-77)75(115)96-33-16-24-60(96)74(114)95-63(43(2)3)64(78)104/h7-12,17-20,25-28,38,42-43,50-60,63,97-98,100H,5-6,13-16,21-24,29-37,39-41,77H2,1-4H3,(H2,78,104)(H,81,84)(H,83,105)(H,85,99)(H,86,101)(H,87,111)(H,88,113)(H,89,106)(H,90,109)(H,91,107)(H,92,112)(H,93,108)(H,94,110)(H,95,114)(H,102,103)(H4,79,80,82)/t50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,63-/m0/s1 VEUQHDZWZKLVDG-WVPSHMGMSA-N 50266735 CHEMBL4060118 Melanocortin receptor 4 Mus musculus 930 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266735&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137635396 404858152 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887022 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 2.0 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887023 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 121 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887024 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O InChI=1S/C34H46IN11O5S/c1-19(47)43-24(7-4-14-41-33(37)38)30(49)44-25(8-5-15-42-34(39)40)31(50)46-27(16-20-10-12-22(35)13-11-20)32(51)45-26(29(36)48)17-21-18-52-28-9-3-2-6-23(21)28/h2-3,6,9-13,18,24-27H,4-5,7-8,14-17H2,1H3,(H2,36,48)(H,43,47)(H,44,49)(H,45,51)(H,46,50)(H4,37,38,41)(H4,39,40,42)/t24-,25-,26-,27+/m0/s1 OXZLRHPUSCOQNJ-YIPNQBBMSA-N 50266739 CHEMBL4071063 Melanocortin receptor 4 Mus musculus 93 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266739&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137639815 404858153 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887025 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O InChI=1S/C34H41IN10O5S/c1-19(46)42-28(15-23-16-39-18-41-23)33(50)43-25(6-4-12-40-34(37)38)31(48)45-27(13-20-8-10-22(35)11-9-20)32(49)44-26(30(36)47)14-21-17-51-29-7-3-2-5-24(21)29/h2-3,5,7-11,16-18,25-28H,4,6,12-15H2,1H3,(H2,36,47)(H,39,41)(H,42,46)(H,43,50)(H,44,49)(H,45,48)(H4,37,38,40)/t25-,26-,27+,28-/m0/s1 FYVIFNLHCUTEBN-BPXGVECKSA-N 50266740 CHEMBL4091894 Melanocortin receptor 4 Mus musculus 275 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266740&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137653916 404858154 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887026 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O InChI=1S/C37H43IN8O5S/c1-22(47)43-30(18-23-8-3-2-4-9-23)35(50)44-28(11-7-17-42-37(40)41)34(49)46-31(19-24-13-15-26(38)16-14-24)36(51)45-29(33(39)48)20-25-21-52-32-12-6-5-10-27(25)32/h2-6,8-10,12-16,21,28-31H,7,11,17-20H2,1H3,(H2,39,48)(H,43,47)(H,44,50)(H,45,51)(H,46,49)(H4,40,41,42)/t28-,29-,30-,31+/m0/s1 ZHTTYHJAFCQYBD-XHPANXIASA-N 50266731 CHEMBL4092424 Melanocortin receptor 4 Mus musculus 850 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266731&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137653704 404858148 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887027 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C36H43IN8O5/c1-22(46)42-29(18-23-8-3-2-4-9-23)34(49)43-28(12-7-17-41-36(39)40)33(48)44-30(19-24-13-15-27(37)16-14-24)35(50)45-21-26-11-6-5-10-25(26)20-31(45)32(38)47/h2-6,8-11,13-16,28-31H,7,12,17-21H2,1H3,(H2,38,47)(H,42,46)(H,43,49)(H,44,48)(H4,39,40,41)/t28-,29-,30+,31-/m0/s1 QPTLNEZUBQIIOA-MBEDZMRZSA-N 50266706 CHEMBL4079298 Melanocortin receptor 4 Mus musculus 135 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266706&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137651071 104113930 29067 ZINC14944679 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887028 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C40H45IN8O5/c1-24(50)46-33(21-26-12-15-27-7-2-3-8-28(27)19-26)38(53)47-32(11-6-18-45-40(43)44)37(52)48-34(20-25-13-16-31(41)17-14-25)39(54)49-23-30-10-5-4-9-29(30)22-35(49)36(42)51/h2-5,7-10,12-17,19,32-35H,6,11,18,20-23H2,1H3,(H2,42,51)(H,46,50)(H,47,53)(H,48,52)(H4,43,44,45)/t32-,33+,34+,35-/m0/s1 UUHBORGJBOZMRT-FLLNZLDLSA-N 50266726 CHEMBL4078495 Melanocortin receptor 4 Mus musculus 43 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266726 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266726&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137649368 404858145 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887029 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C32H46IN11O5/c1-19(45)41-23(9-5-15-39-31(35)36)28(47)42-24(10-6-16-40-32(37)38)29(48)44-26(18-21-11-13-22(33)14-12-21)30(49)43-25(27(34)46)17-20-7-3-2-4-8-20/h2-4,7-8,11-14,23-26H,5-6,9-10,15-18H2,1H3,(H2,34,46)(H,41,45)(H,42,47)(H,43,49)(H,44,48)(H4,35,36,39)(H4,37,38,40)/t23-,24-,25-,26+/m0/s1 NVDGFOWDLBIVFD-ASDGIDEWSA-N 50266708 CHEMBL4102774 Melanocortin receptor 4 Mus musculus 455 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266708&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137658359 104113932 75323 ZINC05225520 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887030 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C39H45IN8O5/c1-24(49)45-33(23-27-13-16-28-10-5-6-11-29(28)20-27)37(52)46-31(12-7-19-44-39(42)43)36(51)48-34(22-26-14-17-30(40)18-15-26)38(53)47-32(35(41)50)21-25-8-3-2-4-9-25/h2-6,8-11,13-18,20,31-34H,7,12,19,21-23H2,1H3,(H2,41,50)(H,45,49)(H,46,52)(H,47,53)(H,48,51)(H4,42,43,44)/t31-,32-,33+,34+/m0/s1 RWTGFQZJEQFICN-PSWJWLENSA-N 50266713 CHEMBL4089759 Melanocortin receptor 4 Mus musculus 126 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266713&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137642804 404858136 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887070 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.800000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887103 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C39H45IN8O5/c1-24(49)45-33(21-25-8-3-2-4-9-25)37(52)46-31(12-7-19-44-39(42)43)36(51)48-34(22-26-14-17-30(40)18-15-26)38(53)47-32(35(41)50)23-27-13-16-28-10-5-6-11-29(28)20-27/h2-6,8-11,13-18,20,31-34H,7,12,19,21-23H2,1H3,(H2,41,50)(H,45,49)(H,46,52)(H,47,53)(H,48,51)(H4,42,43,44)/t31-,32+,33-,34+/m0/s1 DFMOTPKFWMRFLR-GJZXTFMBSA-N 50266755 CHEMBL4079580 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266755&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137651782 404858165 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887104 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C43H47IN8O5/c1-26(53)49-37(25-29-13-17-31-8-3-5-10-33(31)22-29)41(56)50-35(11-6-20-48-43(46)47)40(55)52-38(23-27-14-18-34(44)19-15-27)42(57)51-36(39(45)54)24-28-12-16-30-7-2-4-9-32(30)21-28/h2-5,7-10,12-19,21-22,35-38H,6,11,20,23-25H2,1H3,(H2,45,54)(H,49,53)(H,50,56)(H,51,57)(H,52,55)(H4,46,47,48)/t35-,36+,37-,38+/m0/s1 OUNKXHZNGYZMNG-WCTYMAGYSA-N 50266761 CHEMBL4103837 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266761&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137657751 404858170 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887110 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C33H46IN11O5/c1-19(46)42-24(8-4-14-40-32(36)37)29(48)43-25(9-5-15-41-33(38)39)30(49)44-26(16-20-10-12-23(34)13-11-20)31(50)45-18-22-7-3-2-6-21(22)17-27(45)28(35)47/h2-3,6-7,10-13,24-27H,4-5,8-9,14-18H2,1H3,(H2,35,47)(H,42,46)(H,43,48)(H,44,49)(H4,36,37,40)(H4,38,39,41)/t24-,25-,26+,27-/m0/s1 GYPFKQQJLPOFKF-NFGXINMFSA-N 50266704 CHEMBL4083717 Melanocortin receptor 4 Mus musculus 15 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266704&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search PLP 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132180598 104113928 597326 ZINC01532514 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887122 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C33H41IN10O5/c1-19(45)41-26(15-24-16-38-18-40-24)31(48)42-25(7-4-12-39-33(36)37)30(47)43-27(13-20-8-10-23(34)11-9-20)32(49)44-17-22-6-3-2-5-21(22)14-28(44)29(35)46/h2-3,5-6,8-11,16,18,25-28H,4,7,12-15,17H2,1H3,(H2,35,46)(H,38,40)(H,41,45)(H,42,48)(H,43,47)(H4,36,37,39)/t25-,26-,27+,28-/m0/s1 ZMBJSZYTIJFURY-BPXGVECKSA-N 50266696 CHEMBL4063911 Melanocortin receptor 4 Mus musculus 83 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266696 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266696&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 132180597 404858126 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887123 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C33H46IN11O5/c1-19(46)42-24(8-4-14-40-32(36)37)29(48)43-25(9-5-15-41-33(38)39)30(49)44-26(16-20-10-12-23(34)13-11-20)31(50)45-18-22-7-3-2-6-21(22)17-27(45)28(35)47/h2-3,6-7,10-13,24-27H,4-5,8-9,14-18H2,1H3,(H2,35,47)(H,42,46)(H,43,48)(H,44,49)(H4,36,37,40)(H4,38,39,41)/t24-,25-,26+,27-/m0/s1 GYPFKQQJLPOFKF-NFGXINMFSA-N 50266704 CHEMBL4083717 Melanocortin receptor 4 Mus musculus 13 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266704&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search PLP 1W23,2DAB,1TZ2,1TZM,8GPB,1O61,6RV1,3E9K,3BD8,5HNE,1DGE,1NRG,6THQ,2CFT,2YOB,1DAA,3GJU,1PG8,1E4O,7XOH,3JZ6,8G1Y,2Z20,1BKS,1RVY,1RVU,4QGR,1WW3,1WW2,2SKC,2SKD,2SKE,1JS6,7ME8,1JS3,5B53,6XWL,6XWB,5G2P,6ENZ,2EH6,6CGQ,1DKA,1GFZ,1OHW,1OHY,4QYS,7EIY,2C2B,2C2G,6M5W,2QGH,3DDW,3DDS,3DD1,3G8M,6SSD,5MEM,1AKA,1QU4,3II0,7KMC,1M32,5LH9,1I48,1I43,7TA1,2F3Q,7KB1,7K0J,7K0K,7K0I,1HLF,2A1H,3TFT,4FL0,1N2T,7DBE,1Z62,1YOO,4M2M,4M2K,4M2J,5HXX,3NYS,7KH2,4BF5,6F5V,1ET0,5LUC,6CZZ,6QKB,3ISL,2D7Z,2D7Y,7YEO,1W7M,1W7L,1VE1,1VE5,3VSD,3VSC,3VSA,2X8U,7NWB,7NWC,7NWA,6W1D,1CZC,1CZE,1T3I,2HHF,5LNR,3I5T,7S3G,7S3F,2Z1Z,2Z1Y,4BQF,4BQI,2VGS,2VGU,2VGT,2VGW,2VGV,2VGZ,1WV0,1WV1,4ZLV,1U08,8E9V,8E9T,8E9R,8E9P,8E9Q,8E9N,8E9L,8E9M,8E9J,8E9K,8E9D,7MDB,7MD0,7MD1,7MD8,2AZD,1C9D,3TQX,2EIY,5F9S,1TZK,2ZP7,1GEX,1GEW,6NDN,5OWY,3O05,1LKC,5D5S,1RFU,4NOG,4PFF,4PFN,4YSN,2AQ6,5NM8,6EZL,1N8P,5BW6,5BWA,5BWT,5BWU,5BWV,5BWW,5BWR,5BWX,1VP4,3ZRP,3BDA,3BD7,1IAY,1IAX,4CVQ,1TDJ,5X7N,5X7M,3WQE,3WQD,3WQG,3WQF,3WQC,5M46,5M49,1N31,6N2F,6N2A,3B1D,3B1C,3LV2,3LVM,3LVL,3LVK,3LVJ,3UZO,3UZB,1IJI,5CGQ,6A6E,6A6G,6JIX,6JIF,3RBF,5O52,5O50,5O56,5O54,8AAT,4YI5,4YI3,1O4S,6I33,6I34,1MDZ,1MDX,3A2B,1KO0,2ORD,4ATQ,4ATP,7ODC,4W5K,2CH1,2CH2,4JEY,4JE5,4V15,1GBN,1KKJ,2W7H,2W7I,2W7J,2W7K,2W7L,2W7M,2W7F,2W7G,3CSW,2F3U,7UB4,2D64,2D65,2D66,2D61,2D63,3FDD,2ECO,2ECP,2ECQ,4WR3,5UID,1A3G,4XUG,3I16,1WUY,1WUT,2CST,2V03,4EB7,4EB5,1JBQ,1XKX,7MCU,7MCT,7MCP,7MCY,7MCB,7MCL,7MCN,5C3U,3F9T,1C8V,1C8L,1C8K,6O12,6O10,1QZ9,5K1R,4XEW,5QT3,5Z5C,7FJK,1BX3,7UAU,1GD9,1WBJ,1L6I,4CHI,4UQV,7P3T,4A3Q,2C4M,5I90,4DQ6,2AV6,2WK8,2WK9,1TJP,1FCJ,3L6C,3L6B,4AO9,1NOI,1NOJ,1NOK,3E77,2YXX,6JC9,6K1N,6K1L,6K1M,1LW4,1LW5,1LWN,1LWO,7TCS,1AHP,2AMV,6G4E,6G4D,6G4F,6XO2,1TZJ,1Z7W,3A9Z,3A9Y,1V2F,1V2E,3UYY,3RCH,6SMW,6GIO,2F3S,1ASN,1ASM,1ASB,1ASA,1ASG,1ASF,1ECX,1D2F,1KNW,7AGZ,1K8X,1K8Y,1K8Z,2CIN,6HBV,6T3V,6YRW,4ZGY,5B55,1CX9,2FFR,1EKV,1EKP,1EKF,5GP4,1E1Y,6XIN,1B8G,2ZY3,2ZY2,2ZY5,2ZY4,6Q6I,6KNI,4A6T,2CTZ,4CBS,4CBR,4UOX,5W71,1OAS,1OAT,2ISQ,4H67,4H6D,6ULD,1C7G,1C7N,1KMJ,3C5Q,4XAU,5XT5,2YRR,3KEU,1L7X,6MFB,5JTU,5JTT,7NBD,7NBG,7NBF,7NBC,4YUA,2AW3,5GJO,5GJP,6S4P,6S4R,6S4H,6S4K,6S4O,6FL5,3IF2,6OIA,2OO0,3B8W,3B8V,3B8U,3B8T,2DH5,3BB8,1GPA,1GPB,1YGP,1GPY,3AAT,4CTO,4CTN,4CTM,5X5H,3QBO,2ABJ,7EIX,7EIW,1HKV,6HRH,5O5C,6XNC,1AY8,1AY5,1AY4,6EWQ,5EQC,1XRS,6NZU,1I2K,5CE8,1G7X,1G77,1G76,1G79,1G78,4ZM3,4ZM4,2BYJ,2BYL,6SNU,6SNL,1EQB,2FF5,7BA4,1ARI,1ARS,1ART,6QVL,6QVG,3ELE,1KMK,4BQE,1XI9,1VFH,3GPB,5CR5,4DAA,7NY9,7NY2,1CW2,6FYQ,1TAR,5DDS,1TAT,1B9H,4LW4,1A50,1A5A,1A5S,2VD8,6Q72,6Q70,6Q71,6Q7L,6Q7M,3KKI,4A72,4UHM,4UHO,4UHN,3HQT,7NL1,7M2L,2VMU,2AY1,2AY2,2AY3,2AY4,2AY5,2AY6,2AY7,2AY8,2AY9,7V58,8AYJ,2CJH,2CJD,7Q9X,5VER,7NWM,2PB0,2PB2,2ZUK,5G0A,2HP2,1IYD,6L1L,6L1O,6L1N,5B36,4DGT,2Z67,2ATI,6XDK,6S54,6S52,6S51,4HT3,5ZL6,2DKB,2NV9,2ZB2,3E5P,1IBJ,6WI2,2F3P,5YB0,7T7J,3A9X,7LM0,2O1B,1FG3,4LMB,4LMA,6HUL,2A5H,7RW3,1AXR,1GDE,2E54,2VYC,5E25,7U6U,7LKL,6KFU,3LY1,3BV0,2X3L,4OBU,2P69,2X5F,2YCT,6GKR,1H5U,6UXE,2FET,5BJ3,5BJ4,5OWZ,1KL1,1KL2,1KL7,1XFC,7TM7,6TGH,6MRI,6MRH,6MRE,6MR2,6MR6,4JF1,4R8D,1B4X,5IJG,4B98,4PPM,3MEB,7E13,5ZWA,5C6U,5TXR,7P7X,7NWE,4E1O,6C73,3VBE,6KHP,6KHO,6KHN,3R79,4EMY,7NEA,7NEB,4Y6G,4O6Z,1UZU,2WSY,2J9Z,1C50,2JC3,7V5I,5QQU,5QQT,5QQW,5QQV,5QQQ,5QQS,5QQR,5QQY,5QQX,5QQZ,5Z83,5Z8A,5Z8K,1FC0,1FC4,1M54,7K0P,3BM5,4K6N,1IX6,1IX7,1IX8,3KGW,1L5V,1L5W,1L5Q,1L5R,1L5S,5YHV,4COO,2C7T,2XH1,3DYD,3DXW,4YWR,4Z5X,5WT2,2J66,3AWO,3AWN,1P29,1P2B,3KP1,3AOW,3AOV,1KTI,3DTG,1F2D,6F35,6F3S,6F3R,6F3U,6F3J,6F3L,7CX0,6HTE,2RKB,7RTK,1KFK,1KFB,1KFC,6QA8,6QA6,6QA7,2D1F,4L3V,1K08,1K06,3ZEI,2DGM,2DGL,2DGK,7LTP,6TM7,2CAN,7CWZ,7B4I,1TWI,2W8U,2W8T,2W8V,1P2G,6U7A,6U78,6LDR,4BMK,2E7J,2E7I,1KKP,7GPB,1SF2,1SFT,6UY5,1FS4,1I29,1P4G,1P4J,1P4H,2HP1,3PC2,1VJO,2HDK,2VMO,2VMN,2VMS,2VMR,2VMQ,2VMP,2VMW,2VMV,2VMT,2VMZ,2VMY,2VMX,4W1V,4W1W,4W1X,6KFR,6KFM,7JHW,2CLI,2CLH,2CLK,2CLE,2CLF,2SFP,6KR5,6LIG,1QIS,4GSA,3ATH,4OT8,3FHX,2FYF,4OTL,2EO5,6PK3,6PK1,1GC3,1GC4,1GCK,1WYV,1WYU,1G2W,5OG0,3DOD,1JNW,1ZOB,1ZOD,9GPB,1C4K,4ZU6,3DXV,4AH3,7SZP,1BT4,6PD2,1I1K,1I1M,1I1L,1RCQ,6GWI,5I5S,5I5U,5I5T,5I5W,5I5V,5I5Y,2QN7,2QN9,2QN8,5DX5,5MMS,3TAT,1AAM,1AAW,7V3D,7L47,7L4D 132180598 104113928 597326 ZINC01532514 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887124 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C36H48IN11O5/c1-21(49)45-27(8-4-16-43-35(39)40)32(51)46-28(9-5-17-44-36(41)42)33(52)48-30(19-22-11-14-26(37)15-12-22)34(53)47-29(31(38)50)20-23-10-13-24-6-2-3-7-25(24)18-23/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,50)(H,45,49)(H,46,51)(H,47,53)(H,48,52)(H4,39,40,43)(H4,41,42,44)/t27-,28-,29+,30+/m0/s1 VLHRNMSUNLFBOW-VZNYXHRGSA-N 50266722 CHEMBL4072129 Melanocortin receptor 4 Mus musculus 220 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266722 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266722&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 132180599 404858141 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887125 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C35H43IN8O5/c1-22(45)41-29(20-24-11-6-3-7-12-24)33(48)42-27(13-8-18-40-35(38)39)32(47)44-30(21-25-14-16-26(36)17-15-25)34(49)43-28(31(37)46)19-23-9-4-2-5-10-23/h2-7,9-12,14-17,27-30H,8,13,18-21H2,1H3,(H2,37,46)(H,41,45)(H,42,48)(H,43,49)(H,44,47)(H4,38,39,40)/t27-,28-,29-,30+/m0/s1 WIUOEPBYUPXBFI-GCXHJFECSA-N 50266747 CHEMBL4101856 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137661509 404858157 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887126 CC(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C45H49IN8O5/c1-28(55)51-39(25-29-13-18-34(19-14-29)32-8-3-2-4-9-32)43(58)52-37(12-7-23-50-45(48)49)42(57)54-40(26-30-16-21-36(46)22-17-30)44(59)53-38(41(47)56)27-31-15-20-33-10-5-6-11-35(33)24-31/h2-6,8-11,13-22,24,37-40H,7,12,23,25-27H2,1H3,(H2,47,56)(H,51,55)(H,52,58)(H,53,59)(H,54,57)(H4,48,49,50)/t37-,38-,39-,40+/m0/s1 PGSXLPDELYOSBW-IJERZTCISA-N 50266725 CHEMBL4098164 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266725&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137660192 404858144 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887127 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C39H45IN8O5/c1-24(49)45-33(21-25-8-3-2-4-9-25)37(52)46-31(12-7-19-44-39(42)43)36(51)48-34(22-26-14-17-30(40)18-15-26)38(53)47-32(35(41)50)23-27-13-16-28-10-5-6-11-29(28)20-27/h2-6,8-11,13-18,20,31-34H,7,12,19,21-23H2,1H3,(H2,41,50)(H,45,49)(H,46,52)(H,47,53)(H,48,51)(H4,42,43,44)/t31-,32-,33-,34+/m0/s1 DFMOTPKFWMRFLR-GZXHTMMISA-N 50266752 CHEMBL4060738 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266752&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137635892 404858162 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887128 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 16 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887129 CC(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(N)=O InChI=1S/C45H49IN8O5/c1-28(55)51-39(27-31-15-20-33-10-5-6-11-35(33)24-31)43(58)52-37(12-7-23-50-45(48)49)42(57)54-40(26-30-16-21-36(46)22-17-30)44(59)53-38(41(47)56)25-29-13-18-34(19-14-29)32-8-3-2-4-9-32/h2-6,8-11,13-22,24,37-40H,7,12,23,25-27H2,1H3,(H2,47,56)(H,51,55)(H,52,58)(H,53,59)(H,54,57)(H4,48,49,50)/t37-,38-,39-,40+/m0/s1 BUMLYNRSGDYSCP-IJERZTCISA-N 50266748 CHEMBL4062425 Melanocortin receptor 4 Mus musculus 7900 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266748&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137635701 404858158 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887130 CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1csc2ccccc12)C(N)=O InChI=1S/C37H43IN8O5S/c1-22(47)43-30(18-23-8-3-2-4-9-23)35(50)44-28(11-7-17-42-37(40)41)34(49)46-31(19-24-13-15-26(38)16-14-24)36(51)45-29(33(39)48)20-25-21-52-32-12-6-5-10-27(25)32/h2-6,8-10,12-16,21,28-31H,7,11,17-20H2,1H3,(H2,39,48)(H,43,47)(H,44,50)(H,45,51)(H,46,49)(H4,40,41,42)/t28-,29-,30-,31+/m0/s1 ZHTTYHJAFCQYBD-XHPANXIASA-N 50266731 CHEMBL4092424 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266731&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137653704 404858148 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887131 CC(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C42H47IN8O5/c1-26(52)48-35(22-27-13-17-30(18-14-27)29-8-3-2-4-9-29)40(55)49-34(12-7-21-47-42(45)46)39(54)50-36(23-28-15-19-33(43)20-16-28)41(56)51-25-32-11-6-5-10-31(32)24-37(51)38(44)53/h2-6,8-11,13-20,34-37H,7,12,21-25H2,1H3,(H2,44,53)(H,48,52)(H,49,55)(H,50,54)(H4,45,46,47)/t34-,35-,36+,37-/m0/s1 SYLVGCUVNFAQGW-FBBJYXRJSA-N 50266733 CHEMBL4074368 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266733 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266733&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137640475 404858150 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 50887132 CC(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O InChI=1S/C41H47IN8O5/c1-26(51)47-35(24-28-14-18-31(19-15-28)30-11-6-3-7-12-30)39(54)48-33(13-8-22-46-41(44)45)38(53)50-36(25-29-16-20-32(42)21-17-29)40(55)49-34(37(43)52)23-27-9-4-2-5-10-27/h2-7,9-12,14-21,33-36H,8,13,22-25H2,1H3,(H2,43,52)(H,47,51)(H,48,54)(H,49,55)(H,50,53)(H4,44,45,46)/t33-,34-,35-,36+/m0/s1 LKEAIHXFSIJDBX-SKXFTCKDSA-N 50266746 CHEMBL4064881 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.7b00301 10.7270/Q24170J1 28453292 Doering, SR; Freeman, KT; Schnell, SM; Haslach, EM; Dirain, M; Debevec, G; Geer, P; Santos, RG; Giulianotti, MA; Pinilla, C; Appel, JR; Speth, RC; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50266746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50266746&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 137635794 404858156 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51214859 CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36?,37-,38+,39-,40-,41-/m0/s1 JDKLPDJLXHXHNV-XMWYYVGNSA-N 50499283 CHEMBL3735690 Melanocortin receptor 4 Mus musculus 0.140000 ChEMBL 10.1016/j.bmcl.2015.10.095 10.7270/Q2DN482M 26555357 Tala, SR; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50499283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50499283&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127036484 433911184 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51214860 CCCCC(NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52?,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-DZZRGNEZSA-N 50128358 CHEMBL3629347 Melanocortin receptor 4 Mus musculus 0.470000 ChEMBL 10.1016/j.bmcl.2015.10.095 10.7270/Q2DN482M 26555357 Tala, SR; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50128358&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122194229 104020123 CHEMBL3629347 ZINC13490048 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51214863 CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)69-45-27-46(71)59-21-10-9-17-39(47(55)72)64-51(76)43(25-35-28-61-38-16-8-7-14-37(35)38)67-49(74)41(18-11-22-60-54(56)57)65-50(75)42(24-32-19-20-33-12-5-6-13-34(33)23-32)66-52(77)44(68-53(45)78)26-36-29-58-30-62-36/h5-8,12-14,16,19-20,23,28-30,39-45,61H,3-4,9-11,15,17-18,21-22,24-27H2,1-2H3,(H2,55,72)(H,58,62)(H,59,71)(H,63,70)(H,64,76)(H,65,75)(H,66,77)(H,67,74)(H,68,78)(H,69,73)(H4,56,57,60)/t39-,40?,41-,42+,43-,44-,45-/m0/s1 GGYWLZFXFKFWKL-YEGUTWPFSA-N 50499284 CHEMBL3735607 Melanocortin receptor 4 Mus musculus 0.500 ChEMBL 10.1016/j.bmcl.2015.10.095 10.7270/Q2DN482M 26555357 Tala, SR; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50499284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50499284&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127035019 433911185 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51214871 CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)69-45-27-46(71)59-21-10-9-17-39(47(55)72)64-51(76)43(25-35-28-61-38-16-8-7-14-37(35)38)67-49(74)41(18-11-22-60-54(56)57)65-50(75)42(24-32-19-20-33-12-5-6-13-34(33)23-32)66-52(77)44(68-53(45)78)26-36-29-58-30-62-36/h5-8,12-14,16,19-20,23,28-30,39-45,61H,3-4,9-11,15,17-18,21-22,24-27H2,1-2H3,(H2,55,72)(H,58,62)(H,59,71)(H,63,70)(H,64,76)(H,65,75)(H,66,77)(H,67,74)(H,68,78)(H,69,73)(H4,56,57,60)/t39-,40?,41-,42+,43-,44-,45-/m0/s1 GGYWLZFXFKFWKL-YEGUTWPFSA-N 50499284 CHEMBL3735607 Melanocortin receptor 4 Mus musculus 0.500000 ChEMBL 10.1016/j.bmcl.2015.10.095 10.7270/Q2DN482M 26555357 Tala, SR; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50499284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50499284&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127035019 433911185 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51214873 CCCCC(NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O InChI=1S/C50H69N15O9/c1-3-4-16-36(59-29(2)66)44(69)65-41-25-42(67)55-20-11-10-18-35(43(51)68)60-47(72)39(23-31-26-57-34-17-9-8-15-33(31)34)63-45(70)37(19-12-21-56-50(52)53)61-46(71)38(22-30-13-6-5-7-14-30)62-48(73)40(64-49(41)74)24-32-27-54-28-58-32/h5-9,13-15,17,26-28,35-41,57H,3-4,10-12,16,18-25H2,1-2H3,(H2,51,68)(H,54,58)(H,55,67)(H,59,66)(H,60,72)(H,61,71)(H,62,73)(H,63,70)(H,64,74)(H,65,69)(H4,52,53,56)/t35-,36?,37-,38+,39-,40-,41-/m0/s1 JDKLPDJLXHXHNV-XMWYYVGNSA-N 50499283 CHEMBL3735690 Melanocortin receptor 4 Mus musculus 0.150000 ChEMBL 10.1016/j.bmcl.2015.10.095 10.7270/Q2DN482M 26555357 Tala, SR; Schnell, SM; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50499283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50499283&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 127036484 433911184 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258711 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CS)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C46H57N9O8S/c1-28-39(56)51-34(25-31-17-9-4-10-18-31)45(62)55-22-12-20-38(55)46(63)54-21-11-19-37(54)44(61)53-36(27-64)43(60)50-32(23-29-13-5-2-6-14-29)40(57)49-33(24-30-15-7-3-8-16-30)41(58)52-35(26-47)42(59)48-28/h2-10,13-18,28,32-38,64H,11-12,19-27,47H2,1H3,(H,48,59)(H,49,57)(H,50,60)(H,51,56)(H,52,58)(H,53,61)/t28-,32-,33-,34-,35-,36-,37-,38+/m0/s1 DKTHXDHZNKFNNS-PLUWKHBFSA-N 50514453 CHEMBL4541505 Melanocortin receptor 4 Mus musculus 10000 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514453&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155551202 440723035 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258733 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H64N12O9/c1-30-42(64)60-38(28-33-18-9-4-10-19-33)48(70)62-25-13-22-40(62)49(71)61-24-12-21-39(61)47(69)56-34(20-11-23-54-50(52)53)43(65)57-35(26-31-14-5-2-6-15-31)45(67)58-36(27-32-16-7-3-8-17-32)46(68)59-37(29-41(51)63)44(66)55-30/h2-10,14-19,30,34-40H,11-13,20-29H2,1H3,(H2,51,63)(H,55,66)(H,56,69)(H,57,65)(H,58,67)(H,59,68)(H,60,64)(H4,52,53,54)/t30-,34-,35-,36-,37-,38-,39-,40+/m0/s1 MTKQTEXYJKPBQD-GNDHHEKASA-N 50089398 CHEMBL3577981 Melanocortin receptor 4 Mus musculus 70 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089398&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178151 103988187 CHEMBL3577981 ZINC26489473 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258734 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H59N11O9/c1-30-43(63)59-39(25-33-17-9-4-10-18-33)49(69)61-22-12-20-41(61)50(70)60-21-11-19-40(60)48(68)58-37(26-34-28-52-29-53-34)47(67)56-35(23-31-13-5-2-6-14-31)45(65)55-36(24-32-15-7-3-8-16-32)46(66)57-38(27-42(51)62)44(64)54-30/h2-10,13-18,28-30,35-41H,11-12,19-27H2,1H3,(H2,51,62)(H,52,53)(H,54,64)(H,55,65)(H,56,67)(H,57,66)(H,58,68)(H,59,63)/t30-,35-,36-,37-,38-,39-,40-,41+/m0/s1 GMCVFRQQOHKQTK-HPMMOBRVSA-N 50514456 CHEMBL4587214 Melanocortin receptor 4 Mus musculus 6700 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514456&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155566718 440723038 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258735 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O8/c1-30-41(62)58-37(28-33-18-9-4-10-19-33)47(68)61-25-13-22-40(61)48(69)60-24-12-21-39(60)46(67)55-34(20-11-23-53-49(51)52)42(63)56-35(26-31-14-5-2-6-15-31)43(64)57-36(27-32-16-7-3-8-17-32)44(65)59-38(29-50)45(66)54-30/h2-10,14-19,30,34-40H,11-13,20-29,50H2,1H3,(H,54,66)(H,55,67)(H,56,63)(H,57,64)(H,58,62)(H,59,65)(H4,51,52,53)/t30-,34-,35-,36-,37-,38-,39-,40+/m0/s1 IJUWOYISGCBYSL-GNDHHEKASA-N 50258965 CHEMBL4102048 Melanocortin receptor 4 Mus musculus 1.9 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258965&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 132938008 402361711 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258736 CC(C)[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C51H68N12O8/c1-31(2)42-48(69)59-38(29-34-19-10-5-11-20-34)49(70)63-26-14-23-41(63)50(71)62-25-13-22-40(62)47(68)56-35(21-12-24-55-51(53)54)43(64)57-36(27-32-15-6-3-7-16-32)44(65)58-37(28-33-17-8-4-9-18-33)45(66)60-39(30-52)46(67)61-42/h3-11,15-20,31,35-42H,12-14,21-30,52H2,1-2H3,(H,56,68)(H,57,64)(H,58,65)(H,59,69)(H,60,66)(H,61,67)(H4,53,54,55)/t35-,36-,37-,38-,39-,40-,41+,42-/m0/s1 ZJAPTWLOYMLZGR-WTBBZCIKSA-N 50514457 CHEMBL4565367 Melanocortin receptor 4 Mus musculus 8.2 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514457&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155544852 440723039 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258737 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H59N11O8/c1-30-42(61)57-38(25-33-17-9-4-10-18-33)48(67)60-22-12-20-41(60)49(68)59-21-11-19-40(59)47(66)56-37(26-34-28-51-29-52-34)45(64)55-35(23-31-13-5-2-6-14-31)43(62)54-36(24-32-15-7-3-8-16-32)44(63)58-39(27-50)46(65)53-30/h2-10,13-18,28-30,35-41H,11-12,19-27,50H2,1H3,(H,51,52)(H,53,65)(H,54,62)(H,55,64)(H,56,66)(H,57,61)(H,58,63)/t30-,35-,36-,37-,38-,39-,40-,41+/m0/s1 XIDWPEYKZWKFNR-HPMMOBRVSA-N 50514455 CHEMBL4531291 Melanocortin receptor 4 Mus musculus 1000 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514455&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155546131 440723037 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258754 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H59N11O9/c1-30-43(63)59-39(25-33-17-9-4-10-18-33)49(69)61-22-12-20-41(61)50(70)60-21-11-19-40(60)48(68)58-37(26-34-28-52-29-53-34)47(67)56-35(23-31-13-5-2-6-14-31)45(65)55-36(24-32-15-7-3-8-16-32)46(66)57-38(27-42(51)62)44(64)54-30/h2-10,13-18,28-30,35-41H,11-12,19-27H2,1H3,(H2,51,62)(H,52,53)(H,54,64)(H,55,65)(H,56,67)(H,57,66)(H,58,68)(H,59,63)/t30-,35-,36-,37-,38-,39-,40-,41+/m0/s1 GMCVFRQQOHKQTK-HPMMOBRVSA-N 50514456 CHEMBL4587214 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514456&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155566718 440723038 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258755 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H59N11O8/c1-30-42(61)57-38(25-33-17-9-4-10-18-33)48(67)60-22-12-20-41(60)49(68)59-21-11-19-40(59)47(66)56-37(26-34-28-51-29-52-34)45(64)55-35(23-31-13-5-2-6-14-31)43(62)54-36(24-32-15-7-3-8-16-32)44(63)58-39(27-50)46(65)53-30/h2-10,13-18,28-30,35-41H,11-12,19-27,50H2,1H3,(H,51,52)(H,53,65)(H,54,62)(H,55,64)(H,56,66)(H,57,61)(H,58,63)/t30-,35-,36-,37-,38-,39-,40-,41+/m0/s1 XIDWPEYKZWKFNR-HPMMOBRVSA-N 50514455 CHEMBL4531291 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514455&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155546131 440723037 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258756 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.900000 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258758 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H64N12O10/c1-29-42(65)60-38(27-31-13-6-3-7-14-31)48(71)62-24-10-17-40(62)49(72)61-23-9-16-39(61)47(70)56-34(15-8-22-54-50(52)53)43(66)57-36(26-32-18-20-33(63)21-19-32)45(68)58-35(25-30-11-4-2-5-12-30)46(69)59-37(28-41(51)64)44(67)55-29/h2-7,11-14,18-21,29,34-40,63H,8-10,15-17,22-28H2,1H3,(H2,51,64)(H,55,67)(H,56,70)(H,57,66)(H,58,68)(H,59,69)(H,60,65)(H4,52,53,54)/t29-,34-,35-,36-,37-,38-,39-,40+/m0/s1 DQAIHAMKDFPWFW-MZPDUBGKSA-N 50514452 CHEMBL4466724 Melanocortin receptor 4 Mus musculus 2000 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514452&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155532232 440723034 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258762 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H64N12O10/c1-29-42(65)60-38(27-31-13-6-3-7-14-31)48(71)62-24-10-17-40(62)49(72)61-23-9-16-39(61)47(70)56-34(15-8-22-54-50(52)53)43(66)57-36(26-32-18-20-33(63)21-19-32)45(68)58-35(25-30-11-4-2-5-12-30)46(69)59-37(28-41(51)64)44(67)55-29/h2-7,11-14,18-21,29,34-40,63H,8-10,15-17,22-28H2,1H3,(H2,51,64)(H,55,67)(H,56,70)(H,57,66)(H,58,68)(H,59,69)(H,60,65)(H4,52,53,54)/t29-,34-,35-,36-,37-,38-,39-,40+/m0/s1 DQAIHAMKDFPWFW-MZPDUBGKSA-N 50514452 CHEMBL4466724 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514452&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155532232 440723034 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258766 CC(C)[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C52H68N12O9/c1-31(2)43-49(71)61-39(29-34-19-10-5-11-20-34)50(72)64-26-14-23-41(64)51(73)63-25-13-22-40(63)48(70)57-35(21-12-24-56-52(54)55)44(66)58-36(27-32-15-6-3-7-16-32)45(67)59-37(28-33-17-8-4-9-18-33)46(68)60-38(30-42(53)65)47(69)62-43/h3-11,15-20,31,35-41,43H,12-14,21-30H2,1-2H3,(H2,53,65)(H,57,70)(H,58,66)(H,59,67)(H,60,68)(H,61,71)(H,62,69)(H4,54,55,56)/t35-,36-,37-,38-,39-,40-,41+,43-/m0/s1 LPATVOINCAVXRL-NTBYCYSFSA-N 50514454 CHEMBL4538274 Melanocortin receptor 4 Mus musculus 38 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514454&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155548853 440723036 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258776 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CS)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C47H57N9O9S/c1-28-40(58)53-35(25-31-17-9-4-10-18-31)46(64)56-22-12-20-38(56)47(65)55-21-11-19-37(55)45(63)54-36(27-66)44(62)51-33(24-30-15-7-3-8-16-30)42(60)50-32(23-29-13-5-2-6-14-29)43(61)52-34(26-39(48)57)41(59)49-28/h2-10,13-18,28,32-38,66H,11-12,19-27H2,1H3,(H2,48,57)(H,49,59)(H,50,60)(H,51,62)(H,52,61)(H,53,58)(H,54,63)/t28-,32-,33-,34-,35-,36-,37-,38+/m0/s1 NKZFUEPYJJNRCM-PLUWKHBFSA-N 50514458 CHEMBL4474215 Melanocortin receptor 4 Mus musculus 1900 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514458&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155536962 440723040 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258777 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O9/c1-29-41(63)58-37(27-31-13-6-3-7-14-31)47(69)61-24-10-17-40(61)48(70)60-23-9-16-39(60)46(68)55-34(15-8-22-53-49(51)52)42(64)56-36(26-32-18-20-33(62)21-19-32)43(65)57-35(25-30-11-4-2-5-12-30)44(66)59-38(28-50)45(67)54-29/h2-7,11-14,18-21,29,34-40,62H,8-10,15-17,22-28,50H2,1H3,(H,54,67)(H,55,68)(H,56,64)(H,57,65)(H,58,63)(H,59,66)(H4,51,52,53)/t29-,34-,35-,36-,37-,38-,39-,40+/m0/s1 IABIXDUXGHDRKJ-MZPDUBGKSA-N 50514459 CHEMBL4566163 Melanocortin receptor 4 Mus musculus 134 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514459&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155561116 440723041 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258784 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O9/c1-29-41(63)58-37(27-31-13-6-3-7-14-31)47(69)61-24-10-17-40(61)48(70)60-23-9-16-39(60)46(68)55-34(15-8-22-53-49(51)52)42(64)56-36(26-32-18-20-33(62)21-19-32)43(65)57-35(25-30-11-4-2-5-12-30)44(66)59-38(28-50)45(67)54-29/h2-7,11-14,18-21,29,34-40,62H,8-10,15-17,22-28,50H2,1H3,(H,54,67)(H,55,68)(H,56,64)(H,57,65)(H,58,63)(H,59,66)(H4,51,52,53)/t29-,34-,35-,36-,37-,38-,39-,40+/m0/s1 IABIXDUXGHDRKJ-MZPDUBGKSA-N 50514459 CHEMBL4566163 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514459&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155561116 440723041 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258785 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CS)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C47H57N9O9S/c1-28-40(58)53-35(25-31-17-9-4-10-18-31)46(64)56-22-12-20-38(56)47(65)55-21-11-19-37(55)45(63)54-36(27-66)44(62)51-33(24-30-15-7-3-8-16-30)42(60)50-32(23-29-13-5-2-6-14-29)43(61)52-34(26-39(48)57)41(59)49-28/h2-10,13-18,28,32-38,66H,11-12,19-27H2,1H3,(H2,48,57)(H,49,59)(H,50,60)(H,51,62)(H,52,61)(H,53,58)(H,54,63)/t28-,32-,33-,34-,35-,36-,37-,38+/m0/s1 NKZFUEPYJJNRCM-PLUWKHBFSA-N 50514458 CHEMBL4474215 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50514458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50514458&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155536962 440723040 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51258786 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 1.3 ChEMBL 10.1021/acs.jmedchem.9b00860 10.7270/Q25142KG 31845801 Koerperich, ZM; Ericson, MD; Freeman, KT; Speth, RC; Pogozheva, ID; Mosberg, HI; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250094 CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C37H45N9O6/c1-22(47)43-31(19-24-13-15-26(48)16-14-24)35(51)46-32(18-23-8-3-2-4-9-23)36(52)44-29(12-7-17-41-37(39)40)34(50)45-30(33(38)49)20-25-21-42-28-11-6-5-10-27(25)28/h2-6,8-11,13-16,21,29-32,42,48H,7,12,17-20H2,1H3,(H2,38,49)(H,43,47)(H,44,52)(H,45,50)(H,46,51)(H4,39,40,41)/t29-,30-,31-,32+/m0/s1 IMZZWIWCQOUALL-RTNMLALUSA-N 50017138 CHEMBL3287060 Melanocortin receptor 4 Mus musculus 90 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017138 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017138&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 58658553 242041726 CHEMBL3287060 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250095 CC(C)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C30H43N11O5/c1-16(2)25(41-28(45)24(38-17(3)42)12-19-14-34-15-37-19)29(46)39-22(9-6-10-35-30(32)33)27(44)40-23(26(31)43)11-18-13-36-21-8-5-4-7-20(18)21/h4-5,7-8,13-16,22-25,36H,6,9-12H2,1-3H3,(H2,31,43)(H,34,37)(H,38,42)(H,39,46)(H,40,44)(H,41,45)(H4,32,33,35)/t22-,23-,24-,25-/m0/s1 YNOSPCCUIVJJDQ-QORCZRPOSA-N 50511314 CHEMBL4558851 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511314&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155557606 440719896 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250100 CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C33H43N9O5/c1-20(43)42-16-8-14-28(42)32(47)41-27(17-21-9-3-2-4-10-21)31(46)39-25(13-7-15-37-33(35)36)30(45)40-26(29(34)44)18-22-19-38-24-12-6-5-11-23(22)24/h2-6,9-12,19,25-28,38H,7-8,13-18H2,1H3,(H2,34,44)(H,39,46)(H,40,45)(H,41,47)(H4,35,36,37)/t25-,26-,27+,28-/m0/s1 NSISWBCOSAKMBT-BPXGVECKSA-N 50114750 3-{2-[1-[1-[1-acetyl-(5S)-dihydro-1H-5-pyrrolylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-4-amino(imino)methylamino-(1S)-butylcarboxamido]-2-carbamoylethyl}-1H-indole::CHEMBL320157 Melanocortin receptor 4 Mus musculus 1500 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114750&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10995854 104008821 CHEMBL320157 ZINC26670033 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250116 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C77H109N21O19S/c1-42(2)64(65(79)106)97-75(116)61-20-13-30-98(61)76(117)54(18-10-11-28-78)88-62(103)38-85-66(107)57(34-46-36-84-50-17-9-8-16-49(46)50)94-67(108)51(19-12-29-83-77(80)81)89-70(111)55(32-44-14-6-5-7-15-44)92-72(113)58(35-47-37-82-41-86-47)95-68(109)52(25-26-63(104)105)90-69(110)53(27-31-118-4)91-74(115)60(40-100)96-71(112)56(33-45-21-23-48(102)24-22-45)93-73(114)59(39-99)87-43(3)101/h5-9,14-17,21-24,36-37,41-42,51-61,64,84,99-100,102H,10-13,18-20,25-35,38-40,78H2,1-4H3,(H2,79,106)(H,82,86)(H,85,107)(H,87,101)(H,88,103)(H,89,111)(H,90,110)(H,91,115)(H,92,113)(H,93,114)(H,94,108)(H,95,109)(H,96,112)(H,97,116)(H,104,105)(H4,80,81,83)/t51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-/m0/s1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 50029747 (4S)-4-{[(1S)-1-{[(1S)-1-{[(1S)-1-{[(1S)-1-[({[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}methyl)carbamoyl]-2-(1H-indol-3-yl)ethyl]carbamoyl}-4-carbamimidamidobutyl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-imidazol-5-yl)ethyl]carbamoyl}-4-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]-3-hydroxypropanamido]-4-(methylsulfanyl)butanamido]butanoic acid::(alpha-MSH)Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-S-Y-S-M-E-H-F-R-W-G-K-P-V-NH2::Ac-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His--Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2(alpha-Melanotropin, MSH)::Ac-Ser-Tyr-Ser-Met-Glu-His6-Phe7-Arg8-Trp9-Gly-Lys-Pro-Val-NH2::Ac-ser-tyr-ser-met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2::CHEMBL214332::alpha-MSH (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2)::alpha-MSH; Ac-Ser-Tyr-Ser-Met-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2 Melanocortin receptor 4 Mus musculus 3.7 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50029747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50029747&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16132144 103938767 CHEMBL214332 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250117 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 1.1 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250118 CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C33H44N10O6/c1-19(44)40-25(13-14-28(34)45)31(48)43-27(16-20-8-3-2-4-9-20)32(49)41-24(12-7-15-38-33(36)37)30(47)42-26(29(35)46)17-21-18-39-23-11-6-5-10-22(21)23/h2-6,8-11,18,24-27,39H,7,12-17H2,1H3,(H2,34,45)(H2,35,46)(H,40,44)(H,41,49)(H,42,47)(H,43,48)(H4,36,37,38)/t24-,25-,26-,27+/m0/s1 AFHUURALZPGBOL-YIPNQBBMSA-N 50511321 CHEMBL4590532 Melanocortin receptor 4 Mus musculus 270 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511321&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155567887 440719903 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250119 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C31H36N8O5S/c1-18(40)36-26(13-21-15-33-17-35-21)30(43)38-25(11-19-7-3-2-4-8-19)29(42)39-27(16-45)31(44)37-24(28(32)41)12-20-14-34-23-10-6-5-9-22(20)23/h2-10,14-15,17,24-27,34,45H,11-13,16H2,1H3,(H2,32,41)(H,33,35)(H,36,40)(H,37,44)(H,38,43)(H,39,42)/t24-,25+,26-,27-/m0/s1 MQQBPDHRDGGUNE-XUJYPJAKSA-N 50511317 CHEMBL4574756 Melanocortin receptor 4 Mus musculus 3100 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511317&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9852256 440719899 C02248 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250120 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C29H45N13O5/c1-17(43)39-23(14-19-15-35-16-38-19)27(47)42-22(13-18-7-3-2-4-8-18)26(46)41-21(10-6-12-37-29(33)34)25(45)40-20(24(30)44)9-5-11-36-28(31)32/h2-4,7-8,15-16,20-23H,5-6,9-14H2,1H3,(H2,30,44)(H,35,38)(H,39,43)(H,40,45)(H,41,46)(H,42,47)(H4,31,32,36)(H4,33,34,37)/t20-,21-,22+,23-/m0/s1 PIHNEMPAALDULR-GPJHCHHRSA-N 50511319 CHEMBL4582657 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511319&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155558048 440719901 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250121 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(N)=O InChI=1S/C26H38N10O6/c1-15(38)33-20(11-17-12-30-14-32-17)25(42)35-19(10-16-6-3-2-4-7-16)24(41)34-18(8-5-9-31-26(28)29)23(40)36-21(13-37)22(27)39/h2-4,6-7,12,14,18-21,37H,5,8-11,13H2,1H3,(H2,27,39)(H,30,32)(H,33,38)(H,34,41)(H,35,42)(H,36,40)(H4,28,29,31)/t18-,19+,20-,21-/m0/s1 IOHNYVLPLWAHRY-WOZUAGRISA-N 50511322 CHEMBL4590028 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511322&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155568138 440719904 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250122 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28-,29-/m0/s1 DFCJPPDAOZROBS-DZUOILHNSA-N 50034910 (S)-2-{(S)-2-[(S)-2-acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amideAc-His-DPhe-DArg-Trp-NH2::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide(Ac-His-Phe-Arg-Trp-NH2)::Ac-His-D-Phe-Arg-D-Trp-NH2::Ac-His-DPhe-Arg-Trp-NH2::Ac-His-Phe-Arg-Trp-NH2::CHEMBL50056 Melanocortin receptor 4 Mus musculus 2100 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034910 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034910&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10484741 103943035 CHEMBL50056 ZINC27638796 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250131 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H38N10O5/c1-20(45)41-29(13-23-16-36-18-39-23)33(48)43-28(11-21-7-3-2-4-8-21)32(47)44-30(14-24-17-37-19-40-24)34(49)42-27(31(35)46)12-22-15-38-26-10-6-5-9-25(22)26/h2-10,15-19,27-30,38H,11-14H2,1H3,(H2,35,46)(H,36,39)(H,37,40)(H,41,45)(H,42,49)(H,43,48)(H,44,47)/t27-,28+,29-,30-/m0/s1 RJCHODGMSNLDGL-XJYHXZFBSA-N 50511323 CHEMBL4465466 Melanocortin receptor 4 Mus musculus 500 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511323&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155531140 440719905 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250133 CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(N)=O InChI=1S/C29H44N10O5/c1-17(2)12-22(25(30)41)38-26(42)21(10-7-11-34-29(31)32)37-27(43)23(13-19-8-5-4-6-9-19)39-28(44)24(36-18(3)40)14-20-15-33-16-35-20/h4-6,8-9,15-17,21-24H,7,10-14H2,1-3H3,(H2,30,41)(H,33,35)(H,36,40)(H,37,43)(H,38,42)(H,39,44)(H4,31,32,34)/t21-,22-,23+,24-/m0/s1 QQBVMPFMAWWLKK-XQUALCHDSA-N 50511318 CHEMBL4513953 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511318&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155539056 440719900 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250137 CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H42N8O5/c1-20(2)13-28(32(45)40-27(31(35)44)15-23-17-37-26-12-8-7-11-25(23)26)41-33(46)29(14-22-9-5-4-6-10-22)42-34(47)30(39-21(3)43)16-24-18-36-19-38-24/h4-12,17-20,27-30,37H,13-16H2,1-3H3,(H2,35,44)(H,36,38)(H,39,43)(H,40,45)(H,41,46)(H,42,47)/t27-,28-,29+,30-/m0/s1 VOVYKOVFUGRMDU-ZXYZSCNASA-N 50511315 CHEMBL4437801 Melanocortin receptor 4 Mus musculus 3800 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511315&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155512534 440719897 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250144 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 21 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250145 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O InChI=1S/C25H36N10O5/c1-15(36)33-20(11-17-12-29-14-32-17)24(40)35-19(10-16-6-3-2-4-7-16)23(39)34-18(8-5-9-30-25(27)28)22(38)31-13-21(26)37/h2-4,6-7,12,14,18-20H,5,8-11,13H2,1H3,(H2,26,37)(H,29,32)(H,31,38)(H,33,36)(H,34,39)(H,35,40)(H4,27,28,30)/t18-,19+,20-/m0/s1 SFOKAYXCDPHYOQ-ZCNNSNEGSA-N 50511316 CHEMBL4554278 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511316&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155556608 440719898 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250146 CC(C)C[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C31H45N11O5/c1-17(2)11-25(42-30(47)26(39-18(3)43)13-20-15-35-16-38-20)29(46)40-23(9-6-10-36-31(33)34)28(45)41-24(27(32)44)12-19-14-37-22-8-5-4-7-21(19)22/h4-5,7-8,14-17,23-26,37H,6,9-13H2,1-3H3,(H2,32,44)(H,35,38)(H,39,43)(H,40,46)(H,41,45)(H,42,47)(H4,33,34,36)/t23-,24-,25-,26-/m0/s1 WYTWNUZRDIDXCJ-CQJMVLFOSA-N 50511320 CHEMBL4587259 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511320&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155566585 440719902 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51250151 CC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C33H43N9O5/c1-20(43)42-16-8-14-28(42)32(47)41-27(17-21-9-3-2-4-10-21)31(46)39-25(13-7-15-37-33(35)36)30(45)40-26(29(34)44)18-22-19-38-24-12-6-5-11-23(22)24/h2-6,9-12,19,25-28,38H,7-8,13-18H2,1H3,(H2,34,44)(H,39,46)(H,40,45)(H,41,47)(H4,35,36,37)/t25-,26-,27+,28-/m0/s1 NSISWBCOSAKMBT-BPXGVECKSA-N 50114750 3-{2-[1-[1-[1-acetyl-(5S)-dihydro-1H-5-pyrrolylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-4-amino(imino)methylamino-(1S)-butylcarboxamido]-2-carbamoylethyl}-1H-indole::CHEMBL320157 Melanocortin receptor 4 Mus musculus 1000 ChEMBL 10.1021/acsmedchemlett.9b00198 10.7270/Q2QV3QTB 32184956 Winget, MD; Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50114750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50114750&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10995854 104008821 CHEMBL320157 ZINC26670033 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327524 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C32H43IN8O5/c1-18(2)27(38-19(3)42)30(45)39-24(9-6-14-37-32(35)36)29(44)40-25(15-20-10-12-23(33)13-11-20)31(46)41-17-22-8-5-4-7-21(22)16-26(41)28(34)43/h4-5,7-8,10-13,18,24-27H,6,9,14-17H2,1-3H3,(H2,34,43)(H,38,42)(H,39,45)(H,40,44)(H4,35,36,37)/t24-,25+,26-,27-/m0/s1 FTKVMQSYQHWAOE-XUJYPJAKSA-N 50537087 CHEMBL4547556 Melanocortin receptor 4 Mus musculus 90 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537087 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537087&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155553683 440827911 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327525 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.279000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327533 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O InChI=1S/C32H47ClN10O5/c1-19(44)40-27(16-23-17-37-18-39-23)31(48)41-24(8-5-13-38-32(35)36)29(46)43-26(15-21-9-11-22(33)12-10-21)30(47)42-25(28(34)45)14-20-6-3-2-4-7-20/h9-12,17-18,20,24-27H,2-8,13-16H2,1H3,(H2,34,45)(H,37,39)(H,40,44)(H,41,48)(H,42,47)(H,43,46)(H4,35,36,38)/t24-,25-,26+,27-/m0/s1 CPVMFOXNQUPDOW-NFGXINMFSA-N 50537093 CHEMBL4573041 Melanocortin receptor 4 Mus musculus 380 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537093&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155563055 440827917 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327534 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C33H46ClN11O5/c1-19(46)42-24(8-4-14-40-32(36)37)29(48)43-25(9-5-15-41-33(38)39)30(49)44-26(16-20-10-12-23(34)13-11-20)31(50)45-18-22-7-3-2-6-21(22)17-27(45)28(35)47/h2-3,6-7,10-13,24-27H,4-5,8-9,14-18H2,1H3,(H2,35,47)(H,42,46)(H,43,48)(H,44,49)(H4,36,37,40)(H4,38,39,41)/t24-,25-,26+,27-/m0/s1 QHGVNDDQKJSMFK-NFGXINMFSA-N 50537094 CHEMBL4539621 Melanocortin receptor 4 Mus musculus 26 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537094&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155549760 440827918 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327539 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C32H37IN8O6/c1-18(42)38-25(14-23-15-36-17-37-23)31(46)39-24(10-11-28(34)43)30(45)40-26(12-19-6-8-22(33)9-7-19)32(47)41-16-21-5-3-2-4-20(21)13-27(41)29(35)44/h2-9,15,17,24-27H,10-14,16H2,1H3,(H2,34,43)(H2,35,44)(H,36,37)(H,38,42)(H,39,46)(H,40,45)/t24-,25-,26+,27+/m0/s1 LZEMTIAYLKCDHP-GWMMUDDPSA-N 50537098 CHEMBL4538225 Melanocortin receptor 4 Mus musculus 6500 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537098&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155549385 440827922 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327540 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O InChI=1S/C32H52ClN11O5/c1-19(45)41-23(9-5-15-39-31(35)36)28(47)42-24(10-6-16-40-32(37)38)29(48)44-26(18-21-11-13-22(33)14-12-21)30(49)43-25(27(34)46)17-20-7-3-2-4-8-20/h11-14,20,23-26H,2-10,15-18H2,1H3,(H2,34,46)(H,41,45)(H,42,47)(H,43,49)(H,44,48)(H4,35,36,39)(H4,37,38,40)/t23-,24-,25-,26+/m0/s1 AXUJJCQTNWSUOF-ASDGIDEWSA-N 50537099 CHEMBL4515666 Melanocortin receptor 4 Mus musculus 260 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537099&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155539948 440827923 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327566 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O InChI=1S/C32H47IN10O5/c1-19(44)40-27(16-23-17-37-18-39-23)31(48)41-24(8-5-13-38-32(35)36)29(46)43-26(15-21-9-11-22(33)12-10-21)30(47)42-25(28(34)45)14-20-6-3-2-4-7-20/h9-12,17-18,20,24-27H,2-8,13-16H2,1H3,(H2,34,45)(H,37,39)(H,40,44)(H,41,48)(H,42,47)(H,43,46)(H4,35,36,38)/t24-,25-,26+,27-/m0/s1 VSKPCOABWQAWNK-NFGXINMFSA-N 50537114 CHEMBL4550582 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537114&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155555182 440827938 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327567 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C33H41ClN10O5/c1-19(45)41-26(15-24-16-38-18-40-24)31(48)42-25(7-4-12-39-33(36)37)30(47)43-27(13-20-8-10-23(34)11-9-20)32(49)44-17-22-6-3-2-5-21(22)14-28(44)29(35)46/h2-3,5-6,8-11,16,18,25-28H,4,7,12-15,17H2,1H3,(H2,35,46)(H,38,40)(H,41,45)(H,42,48)(H,43,47)(H4,36,37,39)/t25-,26-,27+,28-/m0/s1 BEIFOQGYNJPYEP-BPXGVECKSA-N 50537095 CHEMBL4556149 Melanocortin receptor 4 Mus musculus 140 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537095&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155556954 440827919 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327568 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C32H37IN8O6/c1-18(42)38-25(14-23-15-36-17-37-23)31(46)39-24(10-11-28(34)43)30(45)40-26(12-19-6-8-22(33)9-7-19)32(47)41-16-21-5-3-2-4-20(21)13-27(41)29(35)44/h2-9,15,17,24-27H,10-14,16H2,1H3,(H2,34,43)(H2,35,44)(H,36,37)(H,38,42)(H,39,46)(H,40,45)/t24-,25-,26+,27-/m0/s1 LZEMTIAYLKCDHP-NFGXINMFSA-N 50537088 CHEMBL4568647 Melanocortin receptor 4 Mus musculus 9000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537088&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155560756 440827912 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327569 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O InChI=1S/C27H35IN8O6/c1-15(37)33-20(12-18-13-31-14-32-18)26(41)34-19(8-9-23(29)38)25(40)35-21(11-16-4-6-17(28)7-5-16)27(42)36-10-2-3-22(36)24(30)39/h4-7,13-14,19-22H,2-3,8-12H2,1H3,(H2,29,38)(H2,30,39)(H,31,32)(H,33,37)(H,34,41)(H,35,40)/t19-,20-,21+,22+/m0/s1 MGONGWWPXOTWKE-FNAHDJPLSA-N 50537115 CHEMBL4571760 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537115&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155562993 440827939 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327570 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C32H37ClN8O6/c1-18(42)38-25(14-23-15-36-17-37-23)31(46)39-24(10-11-28(34)43)30(45)40-26(12-19-6-8-22(33)9-7-19)32(47)41-16-21-5-3-2-4-20(21)13-27(41)29(35)44/h2-9,15,17,24-27H,10-14,16H2,1H3,(H2,34,43)(H2,35,44)(H,36,37)(H,38,42)(H,39,46)(H,40,45)/t24-,25-,26+,27-/m0/s1 ZFNZYQPWVFEMEP-NFGXINMFSA-N 50537116 CHEMBL4536340 Melanocortin receptor 4 Mus musculus 8000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537116&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155548791 440827940 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327571 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C33H46IN11O5/c1-19(46)42-24(8-4-14-40-32(36)37)29(48)43-25(9-5-15-41-33(38)39)30(49)44-26(16-20-10-12-23(34)13-11-20)31(50)45-18-22-7-3-2-6-21(22)17-27(45)28(35)47/h2-3,6-7,10-13,24-27H,4-5,8-9,14-18H2,1H3,(H2,35,47)(H,42,46)(H,43,48)(H,44,49)(H4,36,37,40)(H4,38,39,41)/t24-,25-,26+,27+/m0/s1 GYPFKQQJLPOFKF-GWMMUDDPSA-N 50537106 CHEMBL4522298 Melanocortin receptor 4 Mus musculus 30 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537106&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155543031 440827930 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327572 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O InChI=1S/C28H44IN11O5/c1-16(41)37-19(5-2-12-35-27(31)32)24(43)38-20(6-3-13-36-28(33)34)25(44)39-21(15-17-8-10-18(29)11-9-17)26(45)40-14-4-7-22(40)23(30)42/h8-11,19-22H,2-7,12-15H2,1H3,(H2,30,42)(H,37,41)(H,38,43)(H,39,44)(H4,31,32,35)(H4,33,34,36)/t19-,20-,21+,22+/m0/s1 YVZZDYHFCURRPG-FNAHDJPLSA-N 50537090 CHEMBL4535510 Melanocortin receptor 4 Mus musculus 6000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537090&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155547842 440827914 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327573 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C32H42IN9O6/c1-18(43)39-23(7-4-14-38-32(36)37)29(46)40-24(12-13-27(34)44)30(47)41-25(15-19-8-10-22(33)11-9-19)31(48)42-17-21-6-3-2-5-20(21)16-26(42)28(35)45/h2-3,5-6,8-11,23-26H,4,7,12-17H2,1H3,(H2,34,44)(H2,35,45)(H,39,43)(H,40,46)(H,41,47)(H4,36,37,38)/t23-,24-,25+,26+/m0/s1 CNZBEMAMJJVIBN-QEGGNFSNSA-N 50537083 CHEMBL4550976 Melanocortin receptor 4 Mus musculus 1300 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537083&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155555217 440827907 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327574 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O InChI=1S/C27H40IN9O6/c1-15(38)34-18(4-2-12-33-27(31)32)24(41)35-19(10-11-22(29)39)25(42)36-20(14-16-6-8-17(28)9-7-16)26(43)37-13-3-5-21(37)23(30)40/h6-9,18-21H,2-5,10-14H2,1H3,(H2,29,39)(H2,30,40)(H,34,38)(H,35,41)(H,36,42)(H4,31,32,33)/t18-,19-,20+,21+/m0/s1 OYUHIGSESZOJBJ-UWHLTILDSA-N 50537108 CHEMBL4513460 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537108&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155538874 440827932 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327575 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C32H42ClN9O6/c1-18(43)39-23(7-4-14-38-32(36)37)29(46)40-24(12-13-27(34)44)30(47)41-25(15-19-8-10-22(33)11-9-19)31(48)42-17-21-6-3-2-5-20(21)16-26(42)28(35)45/h2-3,5-6,8-11,23-26H,4,7,12-17H2,1H3,(H2,34,44)(H2,35,45)(H,39,43)(H,40,46)(H,41,47)(H4,36,37,38)/t23-,24-,25+,26+/m0/s1 WVSPXFSGMWZENE-QEGGNFSNSA-N 50537091 CHEMBL4554828 Melanocortin receptor 4 Mus musculus 6000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537091&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155556047 440827915 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327576 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O InChI=1S/C27H40ClN9O6/c1-15(38)34-18(4-2-12-33-27(31)32)24(41)35-19(10-11-22(29)39)25(42)36-20(14-16-6-8-17(28)9-7-16)26(43)37-13-3-5-21(37)23(30)40/h6-9,18-21H,2-5,10-14H2,1H3,(H2,29,39)(H2,30,40)(H,34,38)(H,35,41)(H,36,42)(H4,31,32,33)/t18-,19-,20+,21+/m0/s1 AQFSRNQRSXLKSH-UWHLTILDSA-N 50537109 CHEMBL4557656 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537109&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155554827 440827933 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327577 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C32H43IN8O5/c1-18(2)27(38-19(3)42)30(45)39-24(9-6-14-37-32(35)36)29(44)40-25(15-20-10-12-23(33)13-11-20)31(46)41-17-22-8-5-4-7-21(22)16-26(41)28(34)43/h4-5,7-8,10-13,18,24-27H,6,9,14-17H2,1-3H3,(H2,34,43)(H,38,42)(H,39,45)(H,40,44)(H4,35,36,37)/t24-,25+,26+,27-/m0/s1 FTKVMQSYQHWAOE-YAOOYPAMSA-N 50537110 CHEMBL4574056 Melanocortin receptor 4 Mus musculus 160 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537110&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155564058 440827934 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327578 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C32H43ClN8O5/c1-18(2)27(38-19(3)42)30(45)39-24(9-6-14-37-32(35)36)29(44)40-25(15-20-10-12-23(33)13-11-20)31(46)41-17-22-8-5-4-7-21(22)16-26(41)28(34)43/h4-5,7-8,10-13,18,24-27H,6,9,14-17H2,1-3H3,(H2,34,43)(H,38,42)(H,39,45)(H,40,44)(H4,35,36,37)/t24-,25+,26+,27-/m0/s1 RFBVPLQWBKNMQV-YAOOYPAMSA-N 50537100 CHEMBL4591394 Melanocortin receptor 4 Mus musculus 400 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537100&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155568641 440827924 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327579 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O InChI=1S/C31H49ClN8O5/c1-18(2)26(37-19(3)41)30(45)38-23(10-7-15-36-31(34)35)28(43)40-25(17-21-11-13-22(32)14-12-21)29(44)39-24(27(33)42)16-20-8-5-4-6-9-20/h11-14,18,20,23-26H,4-10,15-17H2,1-3H3,(H2,33,42)(H,37,41)(H,38,45)(H,39,44)(H,40,43)(H4,34,35,36)/t23-,24-,25+,26-/m0/s1 ITUSFZMNBKWORA-SSUZURRFSA-N 50537117 CHEMBL4552764 Melanocortin receptor 4 Mus musculus 1600 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537117&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155556466 440827941 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327580 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1CCC[C@@H]1C(N)=O InChI=1S/C26H37IN6O6/c1-14(2)22(30-15(3)34)25(38)31-18(10-11-21(28)35)24(37)32-19(13-16-6-8-17(27)9-7-16)26(39)33-12-4-5-20(33)23(29)36/h6-9,14,18-20,22H,4-5,10-13H2,1-3H3,(H2,28,35)(H2,29,36)(H,30,34)(H,31,38)(H,32,37)/t18-,19+,20+,22-/m0/s1 YVKLMFVBQKLRDF-HIUFNZKISA-N 50537118 CHEMBL4561005 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537118&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155558598 440827942 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327581 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C31H39ClN6O6/c1-17(2)27(35-18(3)39)30(43)36-23(12-13-26(33)40)29(42)37-24(14-19-8-10-22(32)11-9-19)31(44)38-16-21-7-5-4-6-20(21)15-25(38)28(34)41/h4-11,17,23-25,27H,12-16H2,1-3H3,(H2,33,40)(H2,34,41)(H,35,39)(H,36,43)(H,37,42)/t23-,24+,25-,27-/m0/s1 CJLWXPSNKINPJW-SFIUMABJSA-N 50537113 CHEMBL4541098 Melanocortin receptor 4 Mus musculus 9000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537113&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155551195 440827937 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327650 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C33H41ClN10O5/c1-19(45)41-26(15-24-16-38-18-40-24)31(48)42-25(7-4-12-39-33(36)37)30(47)43-27(13-20-8-10-23(34)11-9-20)32(49)44-17-22-6-3-2-5-21(22)14-28(44)29(35)46/h2-3,5-6,8-11,16,18,25-28H,4,7,12-15,17H2,1H3,(H2,35,46)(H,38,40)(H,41,45)(H,42,48)(H,43,47)(H4,36,37,39)/t25-,26-,27+,28+/m0/s1 BEIFOQGYNJPYEP-YVHASNINSA-N 50537101 CHEMBL4582276 Melanocortin receptor 4 Mus musculus 3100 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537101&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155562237 440827925 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327651 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O InChI=1S/C31H48IN9O6/c1-18(42)38-22(8-5-15-37-31(35)36)28(45)39-23(13-14-26(33)43)29(46)41-25(17-20-9-11-21(32)12-10-20)30(47)40-24(27(34)44)16-19-6-3-2-4-7-19/h9-12,19,22-25H,2-8,13-17H2,1H3,(H2,33,43)(H2,34,44)(H,38,42)(H,39,45)(H,40,47)(H,41,46)(H4,35,36,37)/t22-,23-,24-,25+/m0/s1 UHMFFPSUQXYCRT-OJJQZRKESA-N 50537107 CHEMBL4588429 Melanocortin receptor 4 Mus musculus 2300 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537107&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155567399 440827931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327662 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O InChI=1S/C28H39ClN10O5/c1-16(40)36-21(13-19-14-33-15-35-19)26(43)37-20(4-2-10-34-28(31)32)25(42)38-22(12-17-6-8-18(29)9-7-17)27(44)39-11-3-5-23(39)24(30)41/h6-9,14-15,20-23H,2-5,10-13H2,1H3,(H2,30,41)(H,33,35)(H,36,40)(H,37,43)(H,38,42)(H4,31,32,34)/t20-,21-,22+,23+/m0/s1 MNALDVQJQLZXDP-MYDTUXCISA-N 50537085 CHEMBL4565607 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537085&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155554244 440827909 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327663 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O InChI=1S/C31H43ClN8O6/c1-18(41)37-26(15-22-16-35-17-36-22)31(46)38-23(11-12-27(33)42)29(44)40-25(14-20-7-9-21(32)10-8-20)30(45)39-24(28(34)43)13-19-5-3-2-4-6-19/h7-10,16-17,19,23-26H,2-6,11-15H2,1H3,(H2,33,42)(H2,34,43)(H,35,36)(H,37,41)(H,38,46)(H,39,45)(H,40,44)/t23-,24-,25+,26-/m0/s1 DSPKUBIDSPBFFS-SSUZURRFSA-N 50537105 CHEMBL4539175 Melanocortin receptor 4 Mus musculus 5000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537105&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155549865 440827929 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327664 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C32H42IN9O6/c1-18(43)39-23(7-4-14-38-32(36)37)29(46)40-24(12-13-27(34)44)30(47)41-25(15-19-8-10-22(33)11-9-19)31(48)42-17-21-6-3-2-5-20(21)16-26(42)28(35)45/h2-3,5-6,8-11,23-26H,4,7,12-17H2,1H3,(H2,34,44)(H2,35,45)(H,39,43)(H,40,46)(H,41,47)(H4,36,37,38)/t23-,24-,25+,26-/m0/s1 CNZBEMAMJJVIBN-SSUZURRFSA-N 50537121 CHEMBL4540411 Melanocortin receptor 4 Mus musculus 410 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537121&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155550083 440827945 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327665 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C32H42ClN9O6/c1-18(43)39-23(7-4-14-38-32(36)37)29(46)40-24(12-13-27(34)44)30(47)41-25(15-19-8-10-22(33)11-9-19)31(48)42-17-21-6-3-2-5-20(21)16-26(42)28(35)45/h2-3,5-6,8-11,23-26H,4,7,12-17H2,1H3,(H2,34,44)(H2,35,45)(H,39,43)(H,40,46)(H,41,47)(H4,36,37,38)/t23-,24-,25+,26-/m0/s1 WVSPXFSGMWZENE-SSUZURRFSA-N 50537122 CHEMBL4584189 Melanocortin receptor 4 Mus musculus 1100 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537122&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155566298 440827946 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327666 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C32H43ClN8O5/c1-18(2)27(38-19(3)42)30(45)39-24(9-6-14-37-32(35)36)29(44)40-25(15-20-10-12-23(33)13-11-20)31(46)41-17-22-8-5-4-7-21(22)16-26(41)28(34)43/h4-5,7-8,10-13,18,24-27H,6,9,14-17H2,1-3H3,(H2,34,43)(H,38,42)(H,39,45)(H,40,44)(H4,35,36,37)/t24-,25+,26-,27-/m0/s1 RFBVPLQWBKNMQV-XUJYPJAKSA-N 50537111 CHEMBL4519837 Melanocortin receptor 4 Mus musculus 150 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537111&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155542040 440827935 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327667 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1CCC[C@@H]1C(N)=O InChI=1S/C27H41ClN8O5/c1-15(2)22(33-16(3)37)25(40)34-19(6-4-12-32-27(30)31)24(39)35-20(14-17-8-10-18(28)11-9-17)26(41)36-13-5-7-21(36)23(29)38/h8-11,15,19-22H,4-7,12-14H2,1-3H3,(H2,29,38)(H,33,37)(H,34,40)(H,35,39)(H4,30,31,32)/t19-,20+,21+,22-/m0/s1 UOIKAJRMKYVBJD-CBPXPLCBSA-N 50537123 CHEMBL4555150 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537123&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155555947 440827947 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327675 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C33H46ClN11O5/c1-19(46)42-24(8-4-14-40-32(36)37)29(48)43-25(9-5-15-41-33(38)39)30(49)44-26(16-20-10-12-23(34)13-11-20)31(50)45-18-22-7-3-2-6-21(22)17-27(45)28(35)47/h2-3,6-7,10-13,24-27H,4-5,8-9,14-18H2,1H3,(H2,35,47)(H,42,46)(H,43,48)(H,44,49)(H4,36,37,40)(H4,38,39,41)/t24-,25-,26+,27+/m0/s1 QHGVNDDQKJSMFK-GWMMUDDPSA-N 50537120 CHEMBL4572994 Melanocortin receptor 4 Mus musculus 160 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537120&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155563222 440827944 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327676 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C31H39IN6O6/c1-17(2)27(35-18(3)39)30(43)36-23(12-13-26(33)40)29(42)37-24(14-19-8-10-22(32)11-9-19)31(44)38-16-21-7-5-4-6-20(21)15-25(38)28(34)41/h4-11,17,23-25,27H,12-16H2,1-3H3,(H2,33,40)(H2,34,41)(H,35,39)(H,36,43)(H,37,42)/t23-,24+,25-,27-/m0/s1 GMZNLVJBFAAQFP-SFIUMABJSA-N 50537092 CHEMBL4579448 Melanocortin receptor 4 Mus musculus 3000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537092&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155565321 440827916 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327678 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C31H39IN6O6/c1-17(2)27(35-18(3)39)30(43)36-23(12-13-26(33)40)29(42)37-24(14-19-8-10-22(32)11-9-19)31(44)38-16-21-7-5-4-6-20(21)15-25(38)28(34)41/h4-11,17,23-25,27H,12-16H2,1-3H3,(H2,33,40)(H2,34,41)(H,35,39)(H,36,43)(H,37,42)/t23-,24+,25+,27-/m0/s1 GMZNLVJBFAAQFP-FCRYVSRXSA-N 50537112 CHEMBL4583714 Melanocortin receptor 4 Mus musculus 5000 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537112&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155561743 440827936 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51327681 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](CC1CCCCC1)C(N)=O InChI=1S/C31H48ClN9O6/c1-18(42)38-22(8-5-15-37-31(35)36)28(45)39-23(13-14-26(33)43)29(46)41-25(17-20-9-11-21(32)12-10-20)30(47)40-24(27(34)44)16-19-6-3-2-4-7-19/h9-12,19,22-25H,2-8,13-17H2,1H3,(H2,33,43)(H2,34,44)(H,38,42)(H,39,45)(H,40,47)(H,41,46)(H4,35,36,37)/t22-,23-,24-,25+/m0/s1 SKAXSGOLYXWZMF-OJJQZRKESA-N 50537097 CHEMBL4567480 Melanocortin receptor 4 Mus musculus 1100 ChEMBL 10.1021/acs.jmedchem.9b00053 10.7270/Q2HT2SWG 30741545 Fleming, KA; Freeman, KT; Powers, MD; Santos, RG; Debevec, G; Giulianotti, MA; Houghten, RA; Doering, SR; Pinilla, C; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50537097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50537097&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 155558348 440827921 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389821 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.900000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389822 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O8/c1-30-41(62)58-37(28-33-18-9-4-10-19-33)47(68)61-25-13-22-40(61)48(69)60-24-12-21-39(60)46(67)55-34(20-11-23-53-49(51)52)42(63)56-35(26-31-14-5-2-6-15-31)43(64)57-36(27-32-16-7-3-8-17-32)44(65)59-38(29-50)45(66)54-30/h2-10,14-19,30,34-40H,11-13,20-29,50H2,1H3,(H,54,66)(H,55,67)(H,56,63)(H,57,64)(H,58,62)(H,59,65)(H4,51,52,53)/t30-,34-,35-,36-,37-,38-,39-,40+/m0/s1 IJUWOYISGCBYSL-GNDHHEKASA-N 50258965 CHEMBL4102048 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50258965 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50258965&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 132938008 402361711 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389823 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O8/c1-31-42(63)57-37(27-33-16-7-3-8-17-33)47(68)61-25-13-22-40(61)48(69)60-24-12-21-39(60)45(66)56-35(20-11-23-53-49(51)52)46(67)59(29-34-18-9-4-10-19-34)30-41(62)55-36(26-32-14-5-2-6-15-32)43(64)58-38(28-50)44(65)54-31/h2-10,14-19,31,35-40H,11-13,20-30,50H2,1H3,(H,54,65)(H,55,62)(H,56,66)(H,57,63)(H,58,64)(H4,51,52,53)/t31-,35-,36-,37-,38-,39-,40+/m0/s1 YMFUSEKOQJBWKN-NETOACFBSA-N 50561604 CHEMBL4764556 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561604&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162662360 461831996 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389824 C[C@@H]1NC(=O)[C@H](CN)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O8/c1-31-42(63)57-37(27-33-16-7-3-8-17-33)47(68)61-25-13-22-40(61)48(69)60-24-12-21-39(60)45(66)56-35(20-11-23-53-49(51)52)43(64)58-36(26-32-14-5-2-6-15-32)46(67)59(29-34-18-9-4-10-19-34)30-41(62)55-38(28-50)44(65)54-31/h2-10,14-19,31,35-40H,11-13,20-30,50H2,1H3,(H,54,65)(H,55,62)(H,56,66)(H,57,63)(H,58,64)(H4,51,52,53)/t31-,35-,36-,37-,38-,39-,40+/m0/s1 MAJFZWKRKQTSRH-NETOACFBSA-N 50561605 CHEMBL4747952 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561605&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162650385 461831997 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389825 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H64N12O9/c1-31-43(65)59-38(27-33-16-7-3-8-17-33)48(70)62-25-13-22-40(62)49(71)61-24-12-21-39(61)46(68)57-35(20-11-23-54-50(52)53)47(69)60(29-34-18-9-4-10-19-34)30-42(64)56-36(26-32-14-5-2-6-15-32)45(67)58-37(28-41(51)63)44(66)55-31/h2-10,14-19,31,35-40H,11-13,20-30H2,1H3,(H2,51,63)(H,55,66)(H,56,64)(H,57,68)(H,58,67)(H,59,65)(H4,52,53,54)/t31-,35-,36-,37-,38-,39-,40+/m0/s1 UFZXCHMAENZOST-NETOACFBSA-N 50561606 CHEMBL4785711 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561606&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162667883 461831998 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389826 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(CCCNC(N)=N)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C49H64N12O8/c1-31-42(63)57-37(28-34-18-9-4-10-19-34)46(67)60-24-12-21-40(60)48(69)61-25-11-20-39(61)47(68)59(23-13-22-53-49(51)52)30-41(62)55-35(26-32-14-5-2-6-15-32)43(64)56-36(27-33-16-7-3-8-17-33)44(65)58-38(29-50)45(66)54-31/h2-10,14-19,31,35-40H,11-13,20-30,50H2,1H3,(H,54,66)(H,55,62)(H,56,64)(H,57,63)(H,58,65)(H4,51,52,53)/t31-,35-,36-,37-,38-,39-,40+/m0/s1 FGTXJLSBIKUVQB-NETOACFBSA-N 50561607 CHEMBL4797774 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561607&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162676380 461831999 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389827 CN1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@@H]2C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CN)C1=O InChI=1S/C49H64N12O8/c1-59-30-41(62)54-37(28-33-18-9-4-10-19-33)47(68)61-25-13-22-40(61)48(69)60-24-12-21-39(60)45(66)55-34(20-11-23-53-49(51)52)42(63)56-35(26-31-14-5-2-6-15-31)43(64)57-36(27-32-16-7-3-8-17-32)44(65)58-38(29-50)46(59)67/h2-10,14-19,34-40H,11-13,20-30,50H2,1H3,(H,54,62)(H,55,66)(H,56,63)(H,57,64)(H,58,65)(H4,51,52,53)/t34-,35-,36-,37-,38-,39-,40+/m0/s1 OYZSBZSOEVDVQW-BUXPKPHFSA-N 50561608 CHEMBL4743564 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561608&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162647356 461832000 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389828 C[C@@H]1NC(=O)[C@H](CN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)CN(Cc2ccccc2)C1=O InChI=1S/C49H64N12O8/c1-31-47(68)59(29-34-18-9-4-10-19-34)30-41(62)60-24-13-22-40(60)48(69)61-25-12-21-39(61)46(67)55-35(20-11-23-53-49(51)52)42(63)56-36(26-32-14-5-2-6-15-32)43(64)57-37(27-33-16-7-3-8-17-33)44(65)58-38(28-50)45(66)54-31/h2-10,14-19,31,35-40H,11-13,20-30,50H2,1H3,(H,54,66)(H,55,67)(H,56,63)(H,57,64)(H,58,65)(H4,51,52,53)/t31-,35-,36-,37-,38-,39-,40+/m0/s1 YCLJTMLYPHXJPM-NETOACFBSA-N 50561609 CHEMBL4753150 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561609&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162653604 461832001 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389829 C[C@@H]1NC(=O)CN(CCN)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H66N12O8/c1-32-43(64)58-39(30-35-18-9-4-10-19-35)48(69)62-26-13-22-41(62)49(70)61-25-12-21-40(61)46(67)56-36(20-11-24-54-50(52)53)44(65)57-37(28-33-14-5-2-6-15-33)45(66)59-38(29-34-16-7-3-8-17-34)47(68)60(27-23-51)31-42(63)55-32/h2-10,14-19,32,36-41H,11-13,20-31,51H2,1H3,(H,55,63)(H,56,67)(H,57,65)(H,58,64)(H,59,66)(H4,52,53,54)/t32-,36-,37-,38-,39-,40-,41+/m0/s1 CPQMVJLVQNQWOE-JHGMFKEXSA-N 50561613 CHEMBL4747778 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561613&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162649541 461832005 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389830 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H64N12O9/c1-30-42(64)60-38(28-33-18-9-4-10-19-33)48(70)62-25-13-22-40(62)49(71)61-24-12-21-39(61)47(69)56-34(20-11-23-54-50(52)53)43(65)57-35(26-31-14-5-2-6-15-31)45(67)58-36(27-32-16-7-3-8-17-32)46(68)59-37(29-41(51)63)44(66)55-30/h2-10,14-19,30,34-40H,11-13,20-29H2,1H3,(H2,51,63)(H,55,66)(H,56,69)(H,57,65)(H,58,67)(H,59,68)(H,60,64)(H4,52,53,54)/t30-,34-,35-,36-,37-,38-,39-,40+/m0/s1 MTKQTEXYJKPBQD-GNDHHEKASA-N 50089398 CHEMBL3577981 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50089398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50089398&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 122178151 103988187 CHEMBL3577981 ZINC26489473 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389831 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CN(CCCNC(N)=N)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H64N12O9/c1-31-43(65)59-38(28-34-18-9-4-10-19-34)47(69)61-24-12-21-40(61)49(71)62-25-11-20-39(62)48(70)60(23-13-22-54-50(52)53)30-42(64)56-35(26-32-14-5-2-6-15-32)45(67)57-36(27-33-16-7-3-8-17-33)46(68)58-37(29-41(51)63)44(66)55-31/h2-10,14-19,31,35-40H,11-13,20-30H2,1H3,(H2,51,63)(H,55,66)(H,56,64)(H,57,67)(H,58,68)(H,59,65)(H4,52,53,54)/t31-,35-,36-,37-,38-,39-,40+/m0/s1 YDZQPKRRPVPMCL-NETOACFBSA-N 50561610 CHEMBL4754305 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561610&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162654478 461832002 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389832 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)CN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O InChI=1S/C50H64N12O9/c1-31-43(65)58-38(27-33-16-7-3-8-17-33)48(70)62-25-13-22-40(62)49(71)61-24-12-21-39(61)46(68)57-35(20-11-23-54-50(52)53)44(66)59-37(26-32-14-5-2-6-15-32)47(69)60(29-34-18-9-4-10-19-34)30-42(64)56-36(28-41(51)63)45(67)55-31/h2-10,14-19,31,35-40H,11-13,20-30H2,1H3,(H2,51,63)(H,55,67)(H,56,64)(H,57,68)(H,58,65)(H,59,66)(H4,52,53,54)/t31-,35-,36-,37-,38-,39-,40+/m0/s1 PTAWHKBYGNKZHT-NETOACFBSA-N 50561611 CHEMBL4740561 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561611&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162645080 461832003 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389833 CN1CC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCC[C@@H]2C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C1=O InChI=1S/C50H64N12O9/c1-60-30-42(64)55-37(28-33-18-9-4-10-19-33)48(70)62-25-13-22-40(62)49(71)61-24-12-21-39(61)46(68)56-34(20-11-23-54-50(52)53)43(65)57-35(26-31-14-5-2-6-15-31)44(66)58-36(27-32-16-7-3-8-17-32)45(67)59-38(47(60)69)29-41(51)63/h2-10,14-19,34-40H,11-13,20-30H2,1H3,(H2,51,63)(H,55,64)(H,56,68)(H,57,65)(H,58,66)(H,59,67)(H4,52,53,54)/t34-,35-,36-,37-,38-,39-,40+/m0/s1 KRKOVWQTFADIDL-BUXPKPHFSA-N 50561612 CHEMBL4785157 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561612&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162666162 461832004 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51389834 C[C@@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C(=O)CN(Cc2ccccc2)C1=O InChI=1S/C50H64N12O9/c1-31-48(70)60(29-34-18-9-4-10-19-34)30-42(64)61-24-13-22-40(61)49(71)62-25-12-21-39(62)47(69)56-35(20-11-23-54-50(52)53)43(65)57-36(26-32-14-5-2-6-15-32)45(67)58-37(27-33-16-7-3-8-17-33)46(68)59-38(28-41(51)63)44(66)55-31/h2-10,14-19,31,35-40H,11-13,20-30H2,1H3,(H2,51,63)(H,55,66)(H,56,69)(H,57,65)(H,58,67)(H,59,68)(H4,52,53,54)/t31-,35-,36-,37-,38-,39-,40+/m0/s1 NYCVECHDUDQVRT-NETOACFBSA-N 50561614 CHEMBL4762178 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acsmedchemlett.9b00641 10.7270/Q2VQ36C5 33062177 Ericson, MD; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50561614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50561614&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162660795 461832006 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359770 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C38H47N9O6/c1-23(48)44-29(12-7-19-43-38(41)42)35(51)45-30(17-18-33(39)49)36(52)46-31(20-24-13-15-26(16-14-24)25-8-3-2-4-9-25)37(53)47-22-28-11-6-5-10-27(28)21-32(47)34(40)50/h2-6,8-11,13-16,29-32H,7,12,17-22H2,1H3,(H2,39,49)(H2,40,50)(H,44,48)(H,45,51)(H,46,52)(H4,41,42,43)/t29-,30-,31+,32+/m0/s1 NEXJVRPYTRBUSR-GASGPIRDSA-N 50549825 CHEMBL4765156 Melanocortin receptor 4 Mus musculus 400 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549825&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162661397 461680165 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359771 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.300000 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359772 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(O)=O InChI=1S/C32H41IN8O7/c1-18(42)38-23(7-4-14-37-32(35)36)28(44)39-24(12-13-27(34)43)29(45)40-25(15-19-8-10-22(33)11-9-19)30(46)41-17-21-6-3-2-5-20(21)16-26(41)31(47)48/h2-3,5-6,8-11,23-26H,4,7,12-17H2,1H3,(H2,34,43)(H,38,42)(H,39,44)(H,40,45)(H,47,48)(H4,35,36,37)/t23-,24-,25+,26+/m0/s1 FETGYUUKUUDNBY-QEGGNFSNSA-N 50549826 CHEMBL4785727 Melanocortin receptor 4 Mus musculus 1300 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549826&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162667982 461680166 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359773 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(Cl)cc1)C(=O)N1Cc2ccccc2C[C@@H]1C(O)=O InChI=1S/C32H41ClN8O7/c1-18(42)38-23(7-4-14-37-32(35)36)28(44)39-24(12-13-27(34)43)29(45)40-25(15-19-8-10-22(33)11-9-19)30(46)41-17-21-6-3-2-5-20(21)16-26(41)31(47)48/h2-3,5-6,8-11,23-26H,4,7,12-17H2,1H3,(H2,34,43)(H,38,42)(H,39,44)(H,40,45)(H,47,48)(H4,35,36,37)/t23-,24-,25+,26+/m0/s1 ZHZBDJFVGOEGSD-QEGGNFSNSA-N 50549827 CHEMBL4789938 Melanocortin receptor 4 Mus musculus 6000 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549827&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162669064 461680167 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359774 CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O 50549814 CHEMBL4794484 Melanocortin receptor 4 Mus musculus 320 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549814&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162672755 461680154 C00615 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359775 CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O 50549815 CHEMBL4754987 Melanocortin receptor 4 Mus musculus 320 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549815&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162654633 461680155 C00615 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359776 CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O 50549816 CHEMBL4782762 Melanocortin receptor 4 Mus musculus 10000 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549816&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162664463 461680156 C00615 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359777 CC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O 50549817 CHEMBL4764827 Melanocortin receptor 4 Mus musculus 3980 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549817&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162662213 461680157 C00615 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359778 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C38H48N8O5/c1-23(2)33(43-24(3)47)36(50)44-30(14-9-19-42-38(40)41)35(49)45-31(20-25-15-17-27(18-16-25)26-10-5-4-6-11-26)37(51)46-22-29-13-8-7-12-28(29)21-32(46)34(39)48/h4-8,10-13,15-18,23,30-33H,9,14,19-22H2,1-3H3,(H2,39,48)(H,43,47)(H,44,50)(H,45,49)(H4,40,41,42)/t30-,31+,32-,33-/m0/s1 MGDUVZCMXVPBFU-YGXYGYJOSA-N 50549818 CHEMBL4783292 Melanocortin receptor 4 Mus musculus 400 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549818&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162666503 461680158 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359779 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C38H48N8O5/c1-23(2)33(43-24(3)47)36(50)44-30(14-9-19-42-38(40)41)35(49)45-31(20-25-15-17-27(18-16-25)26-10-5-4-6-11-26)37(51)46-22-29-13-8-7-12-28(29)21-32(46)34(39)48/h4-8,10-13,15-18,23,30-33H,9,14,19-22H2,1-3H3,(H2,39,48)(H,43,47)(H,44,50)(H,45,49)(H4,40,41,42)/t30-,31+,32+,33-/m0/s1 MGDUVZCMXVPBFU-FWGCVNADSA-N 50549819 CHEMBL4791112 Melanocortin receptor 4 Mus musculus 250 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549819&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162670795 461680159 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359780 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C37H44N6O6/c1-22(2)33(40-23(3)44)36(48)41-29(17-18-32(38)45)35(47)42-30(19-24-13-15-26(16-14-24)25-9-5-4-6-10-25)37(49)43-21-28-12-8-7-11-27(28)20-31(43)34(39)46/h4-16,22,29-31,33H,17-21H2,1-3H3,(H2,38,45)(H2,39,46)(H,40,44)(H,41,48)(H,42,47)/t29-,30+,31-,33-/m0/s1 DBLMJXPJVZLBMB-JCCQREKTSA-N 50549820 CHEMBL4765199 Melanocortin receptor 4 Mus musculus >10000 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549820&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162661724 461680160 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359781 CC(C)[C@H](NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C37H44N6O6/c1-22(2)33(40-23(3)44)36(48)41-29(17-18-32(38)45)35(47)42-30(19-24-13-15-26(16-14-24)25-9-5-4-6-10-25)37(49)43-21-28-12-8-7-11-27(28)20-31(43)34(39)46/h4-16,22,29-31,33H,17-21H2,1-3H3,(H2,38,45)(H2,39,46)(H,40,44)(H,41,48)(H,42,47)/t29-,30+,31+,33-/m0/s1 DBLMJXPJVZLBMB-HYVPQZRVSA-N 50549821 CHEMBL4782693 Melanocortin receptor 4 Mus musculus >10000 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549821&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162665266 461680161 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359782 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C39H51N11O5/c1-24(51)47-30(13-7-19-45-38(41)42)35(53)48-31(14-8-20-46-39(43)44)36(54)49-32(21-25-15-17-27(18-16-25)26-9-3-2-4-10-26)37(55)50-23-29-12-6-5-11-28(29)22-33(50)34(40)52/h2-6,9-12,15-18,30-33H,7-8,13-14,19-23H2,1H3,(H2,40,52)(H,47,51)(H,48,53)(H,49,54)(H4,41,42,45)(H4,43,44,46)/t30-,31-,32+,33-/m0/s1 SUYRLPGKCVVVEL-SSNHPIBPSA-N 50549822 CHEMBL4795352 Melanocortin receptor 4 Mus musculus 125 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549822&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162673830 461680162 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359783 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@@H]1C(N)=O InChI=1S/C39H51N11O5/c1-24(51)47-30(13-7-19-45-38(41)42)35(53)48-31(14-8-20-46-39(43)44)36(54)49-32(21-25-15-17-27(18-16-25)26-9-3-2-4-10-26)37(55)50-23-29-12-6-5-11-28(29)22-33(50)34(40)52/h2-6,9-12,15-18,30-33H,7-8,13-14,19-23H2,1H3,(H2,40,52)(H,47,51)(H,48,53)(H,49,54)(H4,41,42,45)(H4,43,44,46)/t30-,31-,32+,33+/m0/s1 SUYRLPGKCVVVEL-UYEZAFAQSA-N 50549823 CHEMBL4748317 Melanocortin receptor 4 Mus musculus 160 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549823&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162649653 461680163 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51359784 CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N1Cc2ccccc2C[C@H]1C(N)=O InChI=1S/C38H47N9O6/c1-23(48)44-29(12-7-19-43-38(41)42)35(51)45-30(17-18-33(39)49)36(52)46-31(20-24-13-15-26(16-14-24)25-8-3-2-4-9-25)37(53)47-22-28-11-6-5-10-27(28)21-32(47)34(40)50/h2-6,8-11,13-16,29-32H,7,12,17-22H2,1H3,(H2,39,49)(H2,40,50)(H,44,48)(H,45,51)(H,46,52)(H4,41,42,43)/t29-,30-,31+,32-/m0/s1 NEXJVRPYTRBUSR-IHZBLBIESA-N 50549824 CHEMBL4792291 Melanocortin receptor 4 Mus musculus 2000 ChEMBL 10.1021/acsmedchemlett.0c00561 10.7270/Q2N301KK 33488972 Ericson, MD; Shaikh, R; Larson, CM; Freeman, KT; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50549824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50549824&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 162671821 461680164 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426240 CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(CC2)C(C)(C)C)C1=N InChI=1S/C37H63N7/c1-26(2)20-32-22-40-35(38)42(32)24-31-14-11-19-41(31)34(21-28-12-9-8-10-13-28)44-25-33(27(3)4)43(36(44)39)23-29-15-17-30(18-16-29)37(5,6)7/h8-10,12-13,26-27,29-34,39H,11,14-25H2,1-7H3,(H2,38,40)/t29?,30?,31-,32+,33-,34+/m0/s1 SFDXDKLEDUMXIC-DGIOHOOTSA-N 50576103 CHEMBL4856539 Melanocortin receptor 4 Mus musculus 100000 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576103&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164613550 471052226 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426241 CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC2CCC(CC2)C(C)(C)C)C1=N InChI=1S/C36H61N7/c1-25(2)31-21-39-34(37)41(31)23-30-14-11-19-40(30)33(20-27-12-9-8-10-13-27)43-24-32(26(3)4)42(35(43)38)22-28-15-17-29(18-16-28)36(5,6)7/h8-10,12-13,25-26,28-33,38H,11,14-24H2,1-7H3,(H2,37,39)/t28?,29?,30-,31-,32-,33+/m0/s1 YFLILZVOXOWUIT-QLXARGDVSA-N 50576117 CHEMBL4850501 Melanocortin receptor 4 Mus musculus 100000 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576117&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164612768 471052240 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421663 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C36H48IN9O5/c1-22(47)43-30(21-24-11-14-25-7-2-3-8-26(25)19-24)34(50)45-29(10-6-18-42-36(40)41)33(49)46-31(20-23-12-15-27(37)16-13-23)35(51)44-28(32(39)48)9-4-5-17-38/h2-3,7-8,11-16,19,28-31H,4-6,9-10,17-18,20-21,38H2,1H3,(H2,39,48)(H,43,47)(H,44,51)(H,45,50)(H,46,49)(H4,40,41,42)/t28-,29+,30-,31-/m1/s1 UZPBROLABIBYNC-YXOGWZJSSA-N 50574229 CHEMBL4848905 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574229&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164612091 471064374 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421664 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C47H50N6O5/c1-30(54)50-41(27-31-17-20-34-10-2-5-13-37(34)24-31)45(56)52-43(29-33-19-22-36-12-4-7-15-39(36)26-33)47(58)53-42(46(57)51-40(44(49)55)16-8-9-23-48)28-32-18-21-35-11-3-6-14-38(35)25-32/h2-7,10-15,17-22,24-26,40-43H,8-9,16,23,27-29,48H2,1H3,(H2,49,55)(H,50,54)(H,51,57)(H,52,56)(H,53,58)/t40-,41-,42-,43-/m1/s1 NHNGIHXOKMSFOD-MRWFHJSOSA-N 50574247 CHEMBL4848987 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574247&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164614909 471064392 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421665 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C43H47IN6O5/c1-27(51)47-37(25-29-13-17-31-8-2-4-10-33(31)22-29)41(53)50-39(26-30-14-18-32-9-3-5-11-34(32)23-30)43(55)49-38(24-28-15-19-35(44)20-16-28)42(54)48-36(40(46)52)12-6-7-21-45/h2-5,8-11,13-20,22-23,36-39H,6-7,12,21,24-26,45H2,1H3,(H2,46,52)(H,47,51)(H,48,54)(H,49,55)(H,50,53)/t36-,37-,38-,39-/m1/s1 AIQRGPUFSZXKMB-WRCAVZGJSA-N 50574249 CHEMBL4863482 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574249 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574249&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164619557 471064394 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421666 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C43H47IN8O5/c1-26(53)49-36(24-28-12-16-30-7-2-4-9-32(30)21-28)40(55)52-38(25-29-13-17-31-8-3-5-10-33(31)22-29)42(57)51-37(23-27-14-18-34(44)19-15-27)41(56)50-35(39(45)54)11-6-20-48-43(46)47/h2-5,7-10,12-19,21-22,35-38H,6,11,20,23-25H2,1H3,(H2,45,54)(H,49,53)(H,50,56)(H,51,57)(H,52,55)(H4,46,47,48)/t35-,36+,37+,38+/m0/s1 LUTZGHOWHQSXSA-ZPAWJIGKSA-N 50574250 CHEMBL4860714 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574250 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574250&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164612516 471064395 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421667 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C47H50N6O5/c1-30(54)50-41(27-31-17-20-34-10-2-5-13-37(34)24-31)45(56)52-43(29-33-19-22-36-12-4-7-15-39(36)26-33)47(58)53-42(46(57)51-40(44(49)55)16-8-9-23-48)28-32-18-21-35-11-3-6-14-38(35)25-32/h2-7,10-15,17-22,24-26,40-43H,8-9,16,23,27-29,48H2,1H3,(H2,49,55)(H,50,54)(H,51,57)(H,52,56)(H,53,58)/t40-,41-,42+,43-/m1/s1 NHNGIHXOKMSFOD-QNXSJEMLSA-N 50574251 CHEMBL4876373 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574251 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574251&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164629117 471064396 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421668 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C47H50N8O5/c1-29(56)52-40(26-30-16-19-33-9-2-5-12-36(33)23-30)44(58)54-42(28-32-18-21-35-11-4-7-14-38(35)25-32)46(60)55-41(27-31-17-20-34-10-3-6-13-37(34)24-31)45(59)53-39(43(48)57)15-8-22-51-47(49)50/h2-7,9-14,16-21,23-25,39-42H,8,15,22,26-28H2,1H3,(H2,48,57)(H,52,56)(H,53,59)(H,54,58)(H,55,60)(H4,49,50,51)/t39-,40+,41-,42+/m0/s1 VAOXNKVUDSXJMW-DIIMNECFSA-N 50574252 CHEMBL4847777 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574252&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164616620 471064397 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421669 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C40H51N9O5/c1-25(50)46-34(23-26-15-17-28-9-2-4-11-30(28)21-26)38(53)48-33(14-8-20-45-40(43)44)37(52)49-35(39(54)47-32(36(42)51)13-6-7-19-41)24-27-16-18-29-10-3-5-12-31(29)22-27/h2-5,9-12,15-18,21-22,32-35H,6-8,13-14,19-20,23-24,41H2,1H3,(H2,42,51)(H,46,50)(H,47,54)(H,48,53)(H,49,52)(H4,43,44,45)/t32-,33+,34-,35-/m1/s1 YZRKLLYZJJPVLG-AOJHZZQJSA-N 50574240 CHEMBL4872732 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574240&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164619091 471064385 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421670 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C40H51N11O5/c1-24(52)48-33(22-25-14-16-27-8-2-4-10-29(27)20-25)37(55)50-32(13-7-19-47-40(44)45)36(54)51-34(23-26-15-17-28-9-3-5-11-30(28)21-26)38(56)49-31(35(41)53)12-6-18-46-39(42)43/h2-5,8-11,14-17,20-21,31-34H,6-7,12-13,18-19,22-23H2,1H3,(H2,41,53)(H,48,52)(H,49,56)(H,50,55)(H,51,54)(H4,42,43,46)(H4,44,45,47)/t31-,32-,33+,34+/m0/s1 NPTYEQVKIVHBRN-PSWJWLENSA-N 50574242 CHEMBL4859395 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574242&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164617040 471064387 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421671 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O 50574228 CHEMBL4870667 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574228&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164625246 471064373 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421672 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C43H47IN8O5/c1-26(53)49-36(23-27-14-18-34(44)19-15-27)40(55)51-38(25-29-13-17-31-8-3-5-10-33(31)22-29)42(57)52-37(24-28-12-16-30-7-2-4-9-32(30)21-28)41(56)50-35(39(45)54)11-6-20-48-43(46)47/h2-5,7-10,12-19,21-22,35-38H,6,11,20,23-25H2,1H3,(H2,45,54)(H,49,53)(H,50,56)(H,51,55)(H,52,57)(H4,46,47,48)/t35-,36+,37+,38+/m0/s1 LKSQYDJAPDOHRU-ZPAWJIGKSA-N 50574232 CHEMBL4845749 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574232&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164609002 471064377 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421673 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O 50574255 CHEMBL4862028 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574255&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164623596 471064400 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421674 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O 50574233 CHEMBL4849756 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574233&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164615544 471064378 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421675 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C39H44I2N6O5/c1-24(48)44-33(21-25-10-15-30(40)16-11-25)37(50)47-35(23-27-9-14-28-6-2-3-7-29(28)20-27)39(52)46-34(22-26-12-17-31(41)18-13-26)38(51)45-32(36(43)49)8-4-5-19-42/h2-3,6-7,9-18,20,32-35H,4-5,8,19,21-23,42H2,1H3,(H2,43,49)(H,44,48)(H,45,51)(H,46,52)(H,47,50)/t32-,33-,34-,35-/m1/s1 QLEAZXNEYDHBJE-BAQBVXSRSA-N 50574234 CHEMBL4862165 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574234&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164620810 471064379 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421676 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C39H44I2N8O5/c1-23(50)46-32(20-24-9-14-29(40)15-10-24)36(52)49-34(22-26-8-13-27-5-2-3-6-28(27)19-26)38(54)48-33(21-25-11-16-30(41)17-12-25)37(53)47-31(35(42)51)7-4-18-45-39(43)44/h2-3,5-6,8-17,19,31-34H,4,7,18,20-22H2,1H3,(H2,42,51)(H,46,50)(H,47,53)(H,48,54)(H,49,52)(H4,43,44,45)/t31-,32+,33+,34+/m0/s1 ZAXQEAJPJNIAPN-KRFMAMIKSA-N 50574256 CHEMBL4866885 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574256 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574256&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164624151 471064401 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421677 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C43H47IN6O5/c1-27(51)47-37(24-28-15-19-35(44)20-16-28)41(53)49-39(26-30-14-18-32-9-3-5-11-34(32)23-30)43(55)50-38(42(54)48-36(40(46)52)12-6-7-21-45)25-29-13-17-31-8-2-4-10-33(31)22-29/h2-5,8-11,13-20,22-23,36-39H,6-7,12,21,24-26,45H2,1H3,(H2,46,52)(H,47,51)(H,48,54)(H,49,53)(H,50,55)/t36-,37-,38+,39-/m1/s1 KMXXQTFGOXONQX-ZBMOXSJNSA-N 50574266 CHEMBL4877234 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574266&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164627733 471064411 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421678 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C43H47IN8O5/c1-26(53)49-36(23-27-14-18-34(44)19-15-27)40(55)51-38(25-29-13-17-31-8-3-5-10-33(31)22-29)42(57)52-37(24-28-12-16-30-7-2-4-9-32(30)21-28)41(56)50-35(39(45)54)11-6-20-48-43(46)47/h2-5,7-10,12-19,21-22,35-38H,6,11,20,23-25H2,1H3,(H2,45,54)(H,49,53)(H,50,56)(H,51,55)(H,52,57)(H4,46,47,48)/t35-,36+,37-,38+/m0/s1 LKSQYDJAPDOHRU-WCTYMAGYSA-N 50574257 CHEMBL4871777 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574257 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574257&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164622957 471064402 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421679 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C36H48IN9O5/c1-22(47)43-30(20-23-12-15-27(37)16-13-23)34(50)45-29(10-6-18-42-36(40)41)33(49)46-31(35(51)44-28(32(39)48)9-4-5-17-38)21-24-11-14-25-7-2-3-8-26(25)19-24/h2-3,7-8,11-16,19,28-31H,4-6,9-10,17-18,20-21,38H2,1H3,(H2,39,48)(H,43,47)(H,44,51)(H,45,50)(H,46,49)(H4,40,41,42)/t28-,29+,30-,31-/m1/s1 GQIQWHJELWBNLI-YXOGWZJSSA-N 50574244 CHEMBL4852476 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574244&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164610096 471064389 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421680 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C36H48IN11O5/c1-21(49)45-29(19-22-11-14-26(37)15-12-22)33(52)47-28(9-5-17-44-36(41)42)32(51)48-30(20-23-10-13-24-6-2-3-7-25(24)18-23)34(53)46-27(31(38)50)8-4-16-43-35(39)40/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,50)(H,45,49)(H,46,53)(H,47,52)(H,48,51)(H4,39,40,43)(H4,41,42,44)/t27-,28-,29+,30+/m0/s1 JFVISPBLQYTSHU-VZNYXHRGSA-N 50574245 CHEMBL4861645 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574245 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574245&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164613676 471064390 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421681 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCCN)C(N)=O 50574235 CHEMBL4866496 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574235&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164620572 471064380 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421682 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O 50574246 CHEMBL4852297 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574246 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574246&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164612217 471064391 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421683 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C32H45I2N9O5/c1-19(44)40-26(17-20-7-11-22(33)12-8-20)30(47)42-25(6-4-16-39-32(37)38)29(46)43-27(18-21-9-13-23(34)14-10-21)31(48)41-24(28(36)45)5-2-3-15-35/h7-14,24-27H,2-6,15-18,35H2,1H3,(H2,36,45)(H,40,44)(H,41,48)(H,42,47)(H,43,46)(H4,37,38,39)/t24-,25+,26-,27-/m1/s1 MGZYKIDOACEPBX-HVWQDESWSA-N 50574236 CHEMBL4848948 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574236&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164613261 471064381 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421684 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C32H45I2N11O5/c1-18(46)42-25(16-19-6-10-21(33)11-7-19)29(49)44-24(5-3-15-41-32(38)39)28(48)45-26(17-20-8-12-22(34)13-9-20)30(50)43-23(27(35)47)4-2-14-40-31(36)37/h6-13,23-26H,2-5,14-17H2,1H3,(H2,35,47)(H,42,46)(H,43,50)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t23-,24-,25+,26+/m0/s1 LEUXLENUTCCIOY-QEGGNFSNSA-N 50574238 CHEMBL4848870 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574238&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164610510 471064383 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421685 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C36H48IN9O5/c1-22(47)43-30(20-23-12-15-27(37)16-13-23)34(50)45-29(10-6-18-42-36(40)41)33(49)46-31(35(51)44-28(32(39)48)9-4-5-17-38)21-24-11-14-25-7-2-3-8-26(25)19-24/h2-3,7-8,11-16,19,28-31H,4-6,9-10,17-18,20-21,38H2,1H3,(H2,39,48)(H,43,47)(H,44,51)(H,45,50)(H,46,49)(H4,40,41,42)/t28-,29+,30-,31+/m1/s1 GQIQWHJELWBNLI-ITGKQZKFSA-N 50574239 CHEMBL4866219 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574239&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164620129 471064384 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421686 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O InChI=1S/C43H47IN8O5/c1-26(53)49-37(23-27-14-18-34(44)19-15-27)41(56)50-35(11-6-20-48-43(46)47)40(55)52-38(25-29-13-17-31-8-3-5-10-33(31)22-29)42(57)51-36(39(45)54)24-28-12-16-30-7-2-4-9-32(30)21-28/h2-5,7-10,12-19,21-22,35-38H,6,11,20,23-25H2,1H3,(H2,45,54)(H,49,53)(H,50,56)(H,51,57)(H,52,55)(H4,46,47,48)/t35-,36+,37+,38-/m0/s1 HUJPRSPSMBVKRV-LQDUMDOSSA-N 50574258 CHEMBL4868611 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574258 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574258&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164623350 471064403 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421687 CC(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C39H44I2N8O5/c1-23(50)46-32(20-24-9-14-29(40)15-10-24)36(52)49-34(22-26-8-13-27-5-2-3-6-28(27)19-26)38(54)48-33(21-25-11-16-30(41)17-12-25)37(53)47-31(35(42)51)7-4-18-45-39(43)44/h2-3,5-6,8-17,19,31-34H,4,7,18,20-22H2,1H3,(H2,42,51)(H,46,50)(H,47,53)(H,48,54)(H,49,52)(H4,43,44,45)/t31-,32-,33-,34-/m0/s1 ZAXQEAJPJNIAPN-CUPIEXAXSA-N 50574260 CHEMBL4874368 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574260 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574260&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164626755 471064405 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421688 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C36H48IN11O5/c1-21(49)45-29(20-23-10-13-24-6-2-3-7-25(24)18-23)33(52)47-28(9-5-17-44-36(41)42)32(51)48-30(19-22-11-14-26(37)15-12-22)34(53)46-27(31(38)50)8-4-16-43-35(39)40/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,50)(H,45,49)(H,46,53)(H,47,52)(H,48,51)(H4,39,40,43)(H4,41,42,44)/t27-,28-,29+,30+/m0/s1 CAOFNAXBJJEHOP-VZNYXHRGSA-N 50574230 CHEMBL4851302 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574230&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164613361 471064375 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421689 CC(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C40H51N9O5/c1-25(50)46-34(23-26-15-17-28-9-2-4-11-30(28)21-26)38(53)48-33(14-8-20-45-40(43)44)37(52)49-35(39(54)47-32(36(42)51)13-6-7-19-41)24-27-16-18-29-10-3-5-12-31(29)22-27/h2-5,9-12,15-18,21-22,32-35H,6-8,13-14,19-20,23-24,41H2,1H3,(H2,42,51)(H,46,50)(H,47,54)(H,48,53)(H,49,52)(H4,43,44,45)/t32-,33+,34-,35+/m1/s1 YZRKLLYZJJPVLG-AXXKPAGNSA-N 50574243 CHEMBL4863637 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574243 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574243&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164618743 471064388 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421690 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C43H47IN6O5/c1-27(51)47-37(24-28-15-19-35(44)20-16-28)41(53)49-39(26-30-14-18-32-9-3-5-11-34(32)23-30)43(55)50-38(42(54)48-36(40(46)52)12-6-7-21-45)25-29-13-17-31-8-2-4-10-33(31)22-29/h2-5,8-11,13-20,22-23,36-39H,6-7,12,21,24-26,45H2,1H3,(H2,46,52)(H,47,51)(H,48,54)(H,49,53)(H,50,55)/t36-,37-,38-,39-/m1/s1 KMXXQTFGOXONQX-WRCAVZGJSA-N 50574254 CHEMBL4872238 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574254 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574254&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164619441 471064399 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51421691 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C43H47IN6O5/c1-27(51)47-37(24-28-15-19-35(44)20-16-28)41(53)49-39(26-30-14-18-32-9-3-5-11-34(32)23-30)43(55)50-38(42(54)48-36(40(46)52)12-6-7-21-45)25-29-13-17-31-8-2-4-10-33(31)22-29/h2-5,8-11,13-20,22-23,36-39H,6-7,12,21,24-26,45H2,1H3,(H2,46,52)(H,47,51)(H,48,54)(H,49,53)(H,50,55)/t36-,37-,38+,39-/m1/s1 KMXXQTFGOXONQX-ZBMOXSJNSA-N 50574266 CHEMBL4877234 Melanocortin receptor 4 Mus musculus >100000 ChEMBL 10.1021/acs.jmedchem.1c01417 10.7270/Q2RR231G 34592820 Ericson, MD; Doering, SR; Larson, CM; Freeman, KT; LaVoi, TM; Donow, HM; Santos, RG; Cho, RH; Koerperich, ZM; Giulianotti, MA; Pinilla, C; Houghten, RA; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574266&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164627733 471064411 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426229 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61-,62-,65-/m0/s1 UAHFGYDRQSXQEB-LEBBXHLNSA-N 50017181 CHEMBL441738 Melanocortin receptor 4 Mus musculus 0.120000 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017181&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 16197727 242041768 CHEMBL441738 DB04931 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426230 CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(O)=O InChI=1S/C75H106N20O19S/c1-41(2)62(74(113)114)94-72(111)59-19-12-29-95(59)73(112)53(17-9-10-27-76)85-60(99)37-83-64(103)56(33-44-35-82-49-16-8-7-15-47(44)49)91-65(104)50(18-11-28-81-75(78)79)86-68(107)55(31-42-13-5-4-6-14-42)90-70(109)57(34-45-36-80-40-84-45)92-66(105)51(24-25-61(100)101)87-67(106)52(26-30-115-3)88-71(110)58(39-97)93-69(108)54(89-63(102)48(77)38-96)32-43-20-22-46(98)23-21-43/h4-8,13-16,20-23,35-36,40-41,48,50-59,62,82,96-98H,9-12,17-19,24-34,37-39,76-77H2,1-3H3,(H,80,84)(H,83,103)(H,85,99)(H,86,107)(H,87,106)(H,88,110)(H,89,102)(H,90,109)(H,91,104)(H,92,105)(H,93,108)(H,94,111)(H,100,101)(H,113,114)(H4,78,79,81)/t48-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,62-/m0/s1 VGBVAARMQYYITG-DESRROFGSA-N 50576095 CHEMBL438402 Melanocortin receptor 4 Mus musculus 1.6 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576095&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 44349184 471052218 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426231 CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1 DFCJPPDAOZROBS-FKWFRFQNSA-N 50034922 (S)-2-{(R)-2-[(S)-2-Acetylamino-3-(1H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::(S)-2-{(R)-2-[(S)-2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [(S)-1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::1N-[1-carbamoyl-2-(1H-3-indolyl)-(1S)-ethyl]-5-amino(imino)methylamino-2-[1-[2-(1H-5-imidazolyl)-1-methylcarboxamido-(1S)-ethylcarboxamido]-2-phenyl-(1R)-ethylcarboxamido]-(2S)-pentanamide::2-{2-[2-Acetylamino-3-(3H-imidazol-4-yl)-propionylamino]-3-phenyl-propionylamino}-5-guanidino-pentanoic acid [1-carbamoyl-2-(1H-indol-3-yl)-ethyl]-amide::Ac-His-DPhe-Arg-Trp-NH2::CHEMBL264190 Melanocortin receptor 4 Mus musculus 5.5 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50034922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50034922&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 11093672 103943037 CHEMBL264190 ZINC29464356 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426232 Clc1ccc(C[C@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1 InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30+/m1/s1 HLCHESOMJVGDSJ-IHLOFXLRSA-N 50119370 1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid [1-(4-chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,4]triazol-1-ylmethyl-piperidin-1-yl)-2-oxo-ethyl]-amide::CHEMBL342954 Melanocortin receptor 4 Mus musculus 0.900000 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50119370 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50119370&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 10886436 104012588 CHEMBL342954 ZINC27523473 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426233 CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N InChI=1S/C36H63N7O/c1-24(2)12-31-20-39-34(37)41(31)21-30-10-7-11-40(30)33(16-26-8-5-4-6-9-26)42-22-32(25(3)44)43(35(42)38)23-36-17-27-13-28(18-36)15-29(14-27)19-36/h24-33,38,44H,4-23H2,1-3H3,(H2,37,39)/t25-,27?,28?,29?,30+,31-,32+,33-,36?/m1/s1 GNNZXNGIADKZAV-MZMRVWRASA-N 50576094 CHEMBL4863206 Melanocortin receptor 4 Mus musculus 650 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576094&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164619151 471052217 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426234 CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](CC1CCCCC1)N1C[C@@H]([C@@H](C)O)N(CC2CCC(CC2)C(C)(C)C)C1=N InChI=1S/C36H67N7O/c1-25(2)19-31-21-39-34(37)41(31)23-30-13-10-18-40(30)33(20-27-11-8-7-9-12-27)43-24-32(26(3)44)42(35(43)38)22-28-14-16-29(17-15-28)36(4,5)6/h25-33,38,44H,7-24H2,1-6H3,(H2,37,39)/t26-,28?,29?,30+,31-,32+,33-/m1/s1 SOXWMTWUXSCESZ-PPHWUNPRSA-N 50576096 CHEMBL4868636 Melanocortin receptor 4 Mus musculus 270 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576096&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164623811 471052219 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426235 CCC[C@@H]1CN([C@H](CC2CCCCC2)N2CCC[C@H]2CN2[C@H](CC(C)C)CNC2=N)C(=N)N1CCCC(C)C InChI=1S/C32H61N7/c1-6-12-27-23-39(32(34)37(27)18-10-13-24(2)3)30(20-26-14-8-7-9-15-26)36-17-11-16-28(36)22-38-29(19-25(4)5)21-35-31(38)33/h24-30,34H,6-23H2,1-5H3,(H2,33,35)/t27-,28+,29-,30-/m1/s1 ZICAPIHMUSAOAA-GOGZTAQTSA-N 50576099 CHEMBL4877537 Melanocortin receptor 4 Mus musculus 6700 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576099&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164628926 471052222 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426236 CCC[C@@H]1CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2[C@H](CC(C)C)CNC2=N)C(=N)N1CC12CC3CC(CC(C3)C1)C2 InChI=1S/C37H59N7/c1-4-9-31-24-43(36(39)44(31)25-37-19-28-15-29(20-37)17-30(16-28)21-37)34(18-27-10-6-5-7-11-27)41-13-8-12-32(41)23-42-33(14-26(2)3)22-40-35(42)38/h5-7,10-11,26,28-34,39H,4,8-9,12-25H2,1-3H3,(H2,38,40)/t28?,29?,30?,31-,32+,33-,34-,37?/m1/s1 CRBHITDMDNQMDY-GVBQWOKBSA-N 50576101 CHEMBL4871577 Melanocortin receptor 4 Mus musculus 1330 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576101&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164622453 471052224 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426237 CC(C)C[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H](C(C)C)N(CC23CC4CC(CC(C4)C2)C3)C1=N InChI=1S/C37H59N7/c1-25(2)13-32-21-40-35(38)42(32)22-31-11-8-12-41(31)34(17-27-9-6-5-7-10-27)43-23-33(26(3)4)44(36(43)39)24-37-18-28-14-29(19-37)16-30(15-28)20-37/h5-7,9-10,25-26,28-34,39H,8,11-24H2,1-4H3,(H2,38,40)/t28?,29?,30?,31-,32+,33-,34+,37?/m0/s1 KFKTTWFWSXHPDS-WGFPFELBSA-N 50576102 CHEMBL4878922 Melanocortin receptor 4 Mus musculus 8200 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576102&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164627532 471052225 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426238 CC(C)[C@@H]1CNC(=N)N1C[C@@H]1CCCN1[C@@H](Cc1ccccc1)N1C[C@@H]([C@@H](C)O)N(CC23CC4CC(CC(C4)C2)C3)C1=N InChI=1S/C35H55N7O/c1-23(2)30-19-38-33(36)40(30)20-29-10-7-11-39(29)32(15-25-8-5-4-6-9-25)41-21-31(24(3)43)42(34(41)37)22-35-16-26-12-27(17-35)14-28(13-26)18-35/h4-6,8-9,23-24,26-32,37,43H,7,10-22H2,1-3H3,(H2,36,38)/t24-,26?,27?,28?,29+,30+,31+,32-,35?/m1/s1 DBDRKVDUXHMVFB-OUQQWPLESA-N 50576111 CHEMBL4868223 Melanocortin receptor 4 Mus musculus 580 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576111&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164624627 471052234 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51426239 CC(C)CCCN1[C@@H](CN([C@H](Cc2ccccc2)N2CCC[C@H]2CN2[C@H](CC(C)C)CNC2=N)C1=N)[C@@H](C)O InChI=1S/C31H53N7O/c1-22(2)11-9-16-36-28(24(5)39)21-38(31(36)33)29(18-25-12-7-6-8-13-25)35-15-10-14-26(35)20-37-27(17-23(3)4)19-34-30(37)32/h6-8,12-13,22-24,26-29,33,39H,9-11,14-21H2,1-5H3,(H2,32,34)/t24-,26+,27-,28+,29-/m1/s1 MSOLQAURKOZQJZ-YJWDFKAOSA-N 50576124 CHEMBL4851292 Melanocortin receptor 4 Mus musculus 100000 ChEMBL 10.1021/acs.jmedchem.0c02041 10.7270/Q2GT5S0N 33886285 Doering, SR; Freeman, K; Debevec, G; Geer, P; Santos, RG; Lavoi, TM; Giulianotti, MA; Pinilla, C; Appel, JR; Houghten, RA; Ericson, MD; Haskell-Luevano, C University of Minnesota http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50576124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50576124&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164613353 471052247 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554728 CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC1=O)C(N)=O 50080576 CHEMBL3422426 Melanocortin receptor 4 Mus musculus 0.630000 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50080576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50080576&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 9898183 313074187 CHEMBL3422426 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554729 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C36H48IN11O5/c1-21(49)45-29(19-22-11-14-26(37)15-12-22)33(52)47-28(9-5-17-44-36(41)42)32(51)48-30(20-23-10-13-24-6-2-3-7-25(24)18-23)34(53)46-27(31(38)50)8-4-16-43-35(39)40/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,50)(H,45,49)(H,46,53)(H,47,52)(H,48,51)(H4,39,40,43)(H4,41,42,44)/t27-,28-,29+,30-/m0/s1 JFVISPBLQYTSHU-ZXYZSCNASA-N 50574259 CHEMBL4865888 Melanocortin receptor 4 Mus musculus 1.3 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574259&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164619641 471064404 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554730 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C36H43IN10O5/c1-21(48)44-29(16-22-9-12-26(37)13-10-22)33(50)47-31(18-27-19-41-20-43-27)35(52)46-30(17-23-8-11-24-5-2-3-6-25(24)15-23)34(51)45-28(32(38)49)7-4-14-42-36(39)40/h2-3,5-6,8-13,15,19-20,28-31H,4,7,14,16-18H2,1H3,(H2,38,49)(H,41,43)(H,44,48)(H,45,51)(H,46,52)(H,47,50)(H4,39,40,42)/t28-,29+,30-,31-/m0/s1 UTYIBRLTBCAPEN-JVVMDBNWSA-N 50625546 CHEMBL5397668 Melanocortin receptor 4 Mus musculus 100 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625546 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625546&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554731 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C36H48IN9O5/c1-22(47)43-30(20-23-12-15-27(37)16-13-23)34(50)45-29(9-4-5-17-38)33(49)46-31(21-24-11-14-25-7-2-3-8-26(25)19-24)35(51)44-28(32(39)48)10-6-18-42-36(40)41/h2-3,7-8,11-16,19,28-31H,4-6,9-10,17-18,20-21,38H2,1H3,(H2,39,48)(H,43,47)(H,44,51)(H,45,50)(H,46,49)(H4,40,41,42)/t28-,29-,30+,31-/m0/s1 MKMIRPBCQUUNDQ-MBEDZMRZSA-N 50625545 CHEMBL5414015 Melanocortin receptor 4 Mus musculus 8.0 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625545&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554732 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C35H46IN9O5/c1-21(46)42-29(19-22-11-14-26(36)15-12-22)33(49)44-28(8-4-16-37)32(48)45-30(20-23-10-13-24-6-2-3-7-25(24)18-23)34(50)43-27(31(38)47)9-5-17-41-35(39)40/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20,37H2,1H3,(H2,38,47)(H,42,46)(H,43,50)(H,44,49)(H,45,48)(H4,39,40,41)/t27-,28-,29+,30-/m0/s1 GFXVHTVYMKIOIT-ZXYZSCNASA-N 50625544 CHEMBL5438129 Melanocortin receptor 4 Mus musculus 100 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625544 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625544&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554733 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCN)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C34H44IN9O5/c1-20(45)41-28(18-21-9-12-25(35)13-10-21)32(48)43-27(14-15-36)31(47)44-29(19-22-8-11-23-5-2-3-6-24(23)17-22)33(49)42-26(30(37)46)7-4-16-40-34(38)39/h2-3,5-6,8-13,17,26-29H,4,7,14-16,18-19,36H2,1H3,(H2,37,46)(H,41,45)(H,42,49)(H,43,48)(H,44,47)(H4,38,39,40)/t26-,27-,28+,29-/m0/s1 BZXDRURNUJWBEW-FKWFRFQNSA-N 50625543 CHEMBL5421355 Melanocortin receptor 4 Mus musculus 250 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625543&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554734 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CN)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C33H42IN9O5/c1-19(44)40-26(16-20-9-12-24(34)13-10-20)30(46)43-28(18-35)32(48)42-27(17-21-8-11-22-5-2-3-6-23(22)15-21)31(47)41-25(29(36)45)7-4-14-39-33(37)38/h2-3,5-6,8-13,15,25-28H,4,7,14,16-18,35H2,1H3,(H2,36,45)(H,40,44)(H,41,47)(H,42,48)(H,43,46)(H4,37,38,39)/t25-,26+,27-,28-/m0/s1 NFWLCSRZYLNMRU-PUHABZHSSA-N 50625542 CHEMBL5397260 Melanocortin receptor 4 Mus musculus 1600 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625542&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554735 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C37H50IN11O5/c1-22(50)46-30(20-23-12-15-27(38)16-13-23)34(53)48-29(9-4-5-17-44-36(40)41)33(52)49-31(21-24-11-14-25-7-2-3-8-26(25)19-24)35(54)47-28(32(39)51)10-6-18-45-37(42)43/h2-3,7-8,11-16,19,28-31H,4-6,9-10,17-18,20-21H2,1H3,(H2,39,51)(H,46,50)(H,47,54)(H,48,53)(H,49,52)(H4,40,41,44)(H4,42,43,45)/t28-,29-,30+,31-/m0/s1 GJRJYUZGBWRGKK-MBEDZMRZSA-N 50625541 CHEMBL5408661 Melanocortin receptor 4 Mus musculus 1.3 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625541&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554736 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C36H48IN11O5/c1-21(49)45-29(19-22-11-14-26(37)15-12-22)33(52)47-28(9-5-17-44-36(41)42)32(51)48-30(20-23-10-13-24-6-2-3-7-25(24)18-23)34(53)46-27(31(38)50)8-4-16-43-35(39)40/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,50)(H,45,49)(H,46,53)(H,47,52)(H,48,51)(H4,39,40,43)(H4,41,42,44)/t27-,28+,29+,30-/m0/s1 JFVISPBLQYTSHU-KJHMZRPRSA-N 50625540 CHEMBL5435335 Melanocortin receptor 4 Mus musculus 3200 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625540&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554737 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O InChI=1S/C36H47IN10O6/c1-21(48)44-29(19-22-11-14-26(37)15-12-22)33(51)46-28(9-5-17-43-36(41)53)32(50)47-30(20-23-10-13-24-6-2-3-7-25(24)18-23)34(52)45-27(31(38)49)8-4-16-42-35(39)40/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,49)(H,44,48)(H,45,52)(H,46,51)(H,47,50)(H4,39,40,42)(H3,41,43,53)/t27-,28-,29+,30-/m0/s1 CZQQVTYVWZUYCX-ZXYZSCNASA-N 50625538 CHEMBL5409282 Melanocortin receptor 4 Mus musculus 320 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625538 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625538&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554738 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](Cc1c[nH]cn1)C(N)=O InChI=1S/C36H43IN10O5/c1-21(48)44-30(16-22-9-12-26(37)13-10-22)34(51)45-28(7-4-14-42-36(39)40)33(50)47-31(17-23-8-11-24-5-2-3-6-25(24)15-23)35(52)46-29(32(38)49)18-27-19-41-20-43-27/h2-3,5-6,8-13,15,19-20,28-31H,4,7,14,16-18H2,1H3,(H2,38,49)(H,41,43)(H,44,48)(H,45,51)(H,46,52)(H,47,50)(H4,39,40,42)/t28-,29-,30+,31-/m0/s1 UGNYHTRDBISTGJ-MBEDZMRZSA-N 50625537 CHEMBL5417913 Melanocortin receptor 4 Mus musculus 16 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625537&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554739 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCCN)C(N)=O InChI=1S/C36H48IN9O5/c1-22(47)43-30(20-23-12-15-27(37)16-13-23)34(50)45-29(10-6-18-42-36(40)41)33(49)46-31(35(51)44-28(32(39)48)9-4-5-17-38)21-24-11-14-25-7-2-3-8-26(25)19-24/h2-3,7-8,11-16,19,28-31H,4-6,9-10,17-18,20-21,38H2,1H3,(H2,39,48)(H,43,47)(H,44,51)(H,45,50)(H,46,49)(H4,40,41,42)/t28-,29-,30+,31-/m0/s1 GQIQWHJELWBNLI-MBEDZMRZSA-N 50625536 CHEMBL5419394 Melanocortin receptor 4 Mus musculus 6.3 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625536 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625536&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554740 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCN)C(N)=O InChI=1S/C35H46IN9O5/c1-21(46)42-29(19-22-11-14-26(36)15-12-22)33(49)44-28(9-5-17-41-35(39)40)32(48)45-30(34(50)43-27(31(38)47)8-4-16-37)20-23-10-13-24-6-2-3-7-25(24)18-23/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20,37H2,1H3,(H2,38,47)(H,42,46)(H,43,50)(H,44,49)(H,45,48)(H4,39,40,41)/t27-,28-,29+,30-/m0/s1 YEMGKUJZEBAMPK-ZXYZSCNASA-N 50625535 CHEMBL5421386 Melanocortin receptor 4 Mus musculus 1.6 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625535 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625535&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554741 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCN)C(N)=O InChI=1S/C34H44IN9O5/c1-20(45)41-28(18-21-9-12-25(35)13-10-21)32(48)43-27(7-4-16-40-34(38)39)31(47)44-29(33(49)42-26(14-15-36)30(37)46)19-22-8-11-23-5-2-3-6-24(23)17-22/h2-3,5-6,8-13,17,26-29H,4,7,14-16,18-19,36H2,1H3,(H2,37,46)(H,41,45)(H,42,49)(H,43,48)(H,44,47)(H4,38,39,40)/t26-,27-,28+,29-/m0/s1 BWHJRWURSRZJHZ-FKWFRFQNSA-N 50625534 CHEMBL5403689 Melanocortin receptor 4 Mus musculus 1.6 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625534&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554742 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CN)C(N)=O InChI=1S/C33H42IN9O5/c1-19(44)40-26(16-20-9-12-24(34)13-10-20)31(47)41-25(7-4-14-39-33(37)38)30(46)42-27(32(48)43-28(18-35)29(36)45)17-21-8-11-22-5-2-3-6-23(22)15-21/h2-3,5-6,8-13,15,25-28H,4,7,14,16-18,35H2,1H3,(H2,36,45)(H,40,44)(H,41,47)(H,42,46)(H,43,48)(H4,37,38,39)/t25-,26+,27-,28-/m0/s1 VNLHZFSFAHMSBP-PUHABZHSSA-N 50625533 CHEMBL5413452 Melanocortin receptor 4 Mus musculus 8.0 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625533&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554743 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCCNC(N)=N)C(N)=O InChI=1S/C37H50IN11O5/c1-22(50)46-30(20-23-12-15-27(38)16-13-23)34(53)48-29(10-6-18-45-37(42)43)33(52)49-31(21-24-11-14-25-7-2-3-8-26(25)19-24)35(54)47-28(32(39)51)9-4-5-17-44-36(40)41/h2-3,7-8,11-16,19,28-31H,4-6,9-10,17-18,20-21H2,1H3,(H2,39,51)(H,46,50)(H,47,54)(H,48,53)(H,49,52)(H4,40,41,44)(H4,42,43,45)/t28-,29-,30+,31-/m0/s1 KUHFSOMJOLGPCY-MBEDZMRZSA-N 50625532 CHEMBL5405613 Melanocortin receptor 4 Mus musculus 6.3 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625532 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625532&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554744 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCNC(N)=N)C(N)=O InChI=1S/C36H48IN11O5/c1-21(49)45-29(19-22-11-14-26(37)15-12-22)33(52)47-28(9-5-17-44-36(41)42)32(51)48-30(20-23-10-13-24-6-2-3-7-25(24)18-23)34(53)46-27(31(38)50)8-4-16-43-35(39)40/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,50)(H,45,49)(H,46,53)(H,47,52)(H,48,51)(H4,39,40,43)(H4,41,42,44)/t27-,28+,29-,30+/m1/s1 JFVISPBLQYTSHU-ATIZSFMBSA-N 50625531 CHEMBL5406385 Melanocortin receptor 4 Mus musculus 20 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625531 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625531&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554745 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@H](CCCCN)C(N)=O InChI=1S/C36H48IN9O5/c1-22(47)43-30(20-23-12-15-27(37)16-13-23)34(50)45-29(10-6-18-42-36(40)41)33(49)46-31(35(51)44-28(32(39)48)9-4-5-17-38)21-24-11-14-25-7-2-3-8-26(25)19-24/h2-3,7-8,11-16,19,28-31H,4-6,9-10,17-18,20-21,38H2,1H3,(H2,39,48)(H,43,47)(H,44,51)(H,45,50)(H,46,49)(H4,40,41,42)/t28-,29+,30-,31+/m1/s1 GQIQWHJELWBNLI-ITGKQZKFSA-N 50574239 CHEMBL4866219 Melanocortin receptor 4 Mus musculus 20 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50574239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50574239&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 164620129 471064384 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554746 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCCNC(N)=O)C(N)=O InChI=1S/C36H47IN10O6/c1-21(48)44-29(19-22-11-14-26(37)15-12-22)33(51)46-28(9-5-16-42-35(39)40)32(50)47-30(20-23-10-13-24-6-2-3-7-25(24)18-23)34(52)45-27(31(38)49)8-4-17-43-36(41)53/h2-3,6-7,10-15,18,27-30H,4-5,8-9,16-17,19-20H2,1H3,(H2,38,49)(H,44,48)(H,45,52)(H,46,51)(H,47,50)(H4,39,40,42)(H3,41,43,53)/t27-,28-,29+,30-/m0/s1 MHNXMBFPJDRQLN-ZXYZSCNASA-N 50625530 CHEMBL5413535 Melanocortin receptor 4 Mus musculus 3.2 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625530 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625530&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7 51554747 CC(=O)N[C@H](Cc1ccc(I)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CCC(O)=O)C(N)=O InChI=1S/C35H43IN8O7/c1-20(45)41-28(18-21-9-12-25(36)13-10-21)33(50)43-27(7-4-16-40-35(38)39)32(49)44-29(34(51)42-26(31(37)48)14-15-30(46)47)19-22-8-11-23-5-2-3-6-24(23)17-22/h2-3,5-6,8-13,17,26-29H,4,7,14-16,18-19H2,1H3,(H2,37,48)(H,41,45)(H,42,51)(H,43,50)(H,44,49)(H,46,47)(H4,38,39,40)/t26-,27-,28+,29-/m0/s1 KSCWOJVKBKZOFQ-FKWFRFQNSA-N 50625529 CHEMBL5397924 Melanocortin receptor 4 Mus musculus 20 ChEMBL 10.1021/acs.jmedchem.3c00432 10.7270/Q2B56Q5N 37307241 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50625529 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000353&target=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50625529&enzyme=Melanocortin+receptor+4&column=ki&startPg=0&Increment=50&submit=Search 1 MNSTHHHGMYTSLHLWNRSSYGLHGNASESLGKGHPDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLISMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGTNMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELSSRY 8QJ2,7PIV,7PIU,7AUE Melanocortin receptor 4 MC4R_MOUSE P56450 Q49NR4 Q9EQM7