BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 50187351 Clc1ccc(CN2CC[C@H](NCc3cncn3Cc3ccc(cc3)C#N)C2=O)cc1 InChI=1S/C23H22ClN5O/c24-20-7-5-19(6-8-20)14-28-10-9-22(23(28)30)27-13-21-12-26-16-29(21)15-18-3-1-17(11-25)2-4-18/h1-8,12,16,22,27H,9-10,13-15H2/t22-/m0/s1 CSJCILYSGLDOHR-QFIPXVFZSA-N 50103316 4-(5-{[1-(4-Chloro-benzyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL327500 Geranylgeranyl transferase type-1 subunit beta 15000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103316&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9845019 103999615 CHEMBL327500 ZINC13863859 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187352 Clc1cccc(CN2CC[C@H](NCc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 InChI=1S/C23H22ClN5O/c24-20-3-1-2-19(10-20)15-28-9-8-22(23(28)30)27-13-21-12-26-16-29(21)14-18-6-4-17(11-25)5-7-18/h1-7,10,12,16,22,27H,8-9,13-15H2/t22-/m0/s1 VYLMFRUDZGQCNT-QFIPXVFZSA-N 16179 4-{[5-({[(3S)-1-(3-chlorobenzyl)-2-oxopyrrolidin-3-yl]amino}methyl)-1H-imidazol-1-yl]methyl}benzonitrile::4-{[5-({[(3S)-1-[(3-chlorophenyl)methyl]-2-oxopyrrolidin-3-yl]amino}methyl)-1H-imidazol-1-yl]methyl}benzonitrile::CHEMBL312137::MSD-1 Geranylgeranyl transferase type-1 subunit beta 3400 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16179&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9845018 46516435 CHEMBL312137 ZINC53199347 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187353 O=C1[C@H](CCN1c1ccccc1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C22H21N5O/c23-12-17-6-8-18(9-7-17)15-26-16-24-13-20(26)14-25-21-10-11-27(22(21)28)19-4-2-1-3-5-19/h1-9,13,16,21,25H,10-11,14-15H2/t21-/m0/s1 JXSRHAPARDTOCD-NRFANRHFSA-N 50103317 4-{5-[(2-Oxo-1-phenyl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL97925 Geranylgeranyl transferase type-1 subunit beta 46000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103317&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9907452 103999616 CHEMBL97925 ZINC13863844 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187354 Clc1ccccc1CN1CC[C@H](NCc2cncn2Cc2ccc(cc2)C#N)C1=O InChI=1S/C23H22ClN5O/c24-21-4-2-1-3-19(21)15-28-10-9-22(23(28)30)27-13-20-12-26-16-29(20)14-18-7-5-17(11-25)6-8-18/h1-8,12,16,22,27H,9-10,13-15H2/t22-/m0/s1 CZURMACSQFAGFQ-QFIPXVFZSA-N 50103318 4-(5-{[1-(2-Chloro-benzyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL318438 Geranylgeranyl transferase type-1 subunit beta 11000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103318&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9845017 103999617 CHEMBL318438 ZINC13863858 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187355 O=C1[C@H](CCN1c1ccccn1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C21H20N6O/c22-11-16-4-6-17(7-5-16)14-26-15-23-12-18(26)13-25-19-8-10-27(21(19)28)20-3-1-2-9-24-20/h1-7,9,12,15,19,25H,8,10,13-14H2/t19-/m0/s1 SXHQWPNCWHXRFZ-IBGZPJMESA-N 50103320 4-{5-[(2-Oxo-1-pyridin-2-yl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL102031 Geranylgeranyl transferase type-1 subunit beta 36000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103320&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11824866 103999619 CHEMBL102031 ZINC13863860 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187358 Clc1ccc(cc1)C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H22ClN5O/c24-20-7-5-19(6-8-20)23(30)28-10-9-21(15-28)27-13-22-12-26-16-29(22)14-18-3-1-17(11-25)2-4-18/h1-8,12,16,21,27H,9-10,13-15H2/t21-/m0/s1 FZWCVRUEVHYYNZ-NRFANRHFSA-N 50103319 4-(5-{[1-(4-Chloro-benzoyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL101467 Geranylgeranyl transferase type-1 subunit beta 19000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103319&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11037188 103999618 CHEMBL101467 ZINC13863868 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187361 Clc1cccc(c1)N1CC[C@H](NCc2cncn2Cc2ccc(cc2)C#N)C1=O InChI=1S/C22H20ClN5O/c23-18-2-1-3-19(10-18)28-9-8-21(22(28)29)26-13-20-12-25-15-27(20)14-17-6-4-16(11-24)5-7-17/h1-7,10,12,15,21,26H,8-9,13-14H2/t21-/m0/s1 UXDWHSLPIYXEQA-NRFANRHFSA-N 50103323 4-(5-{[1-(3-Chloro-phenyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL99205 Geranylgeranyl transferase type-1 subunit beta 6500 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103323&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11069519 103999622 CHEMBL99205 ZINC13863856 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187363 O=C1[C@H](CCN1Cc1ccccc1)N(CCc1ccccc1)Cc1cncn1Cc1ccc(cc1)C#N InChI=1S/C31H31N5O/c32-19-26-11-13-28(14-12-26)22-36-24-33-20-29(36)23-34(17-15-25-7-3-1-4-8-25)30-16-18-35(31(30)37)21-27-9-5-2-6-10-27/h1-14,20,24,30H,15-18,21-23H2/t30-/m0/s1 NGWHQWBIMKMHDC-PMERELPUSA-N 50103327 4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-phenethyl-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL318943 Geranylgeranyl transferase type-1 subunit beta 15000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103327&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9848397 103999626 CHEMBL318943 ZINC13863880 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187366 O=C1[C@H](CCN1Cc1ccccc1)N(CCCc1ccccc1)Cc1cncn1Cc1ccc(cc1)C#N InChI=1S/C32H33N5O/c33-20-27-13-15-29(16-14-27)23-37-25-34-21-30(37)24-35(18-7-12-26-8-3-1-4-9-26)31-17-19-36(32(31)38)22-28-10-5-2-6-11-28/h1-6,8-11,13-16,21,25,31H,7,12,17-19,22-24H2/t31-/m0/s1 IZVROLMEXNRNHZ-HKBQPEDESA-N 50103332 (S)-4-((5-(((1-benzyl-2-oxopyrrolidin-3-yl)(3-phenylpropyl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile::4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-(3-phenyl-propyl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL329067 Geranylgeranyl transferase type-1 subunit beta 12000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103332 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103332&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9806118 103999631 CHEMBL329067 ZINC13863881 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187369 O=C1[C@H](CCN1CCc1ccccc1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C24H25N5O/c25-14-20-6-8-21(9-7-20)17-29-18-26-15-22(29)16-27-23-11-13-28(24(23)30)12-10-19-4-2-1-3-5-19/h1-9,15,18,23,27H,10-13,16-17H2/t23-/m0/s1 CFMXTSHLOSTNDP-QHCPKHFHSA-N 50103330 4-{5-[(2-Oxo-1-phenethyl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL420833 Geranylgeranyl transferase type-1 subunit beta 48000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103330&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9930818 103999629 CHEMBL420833 ZINC13863848 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187371 Clc1ccccc1N1CC[C@H](NCc2cncn2Cc2ccc(cc2)C#N)C1=O InChI=1S/C22H20ClN5O/c23-19-3-1-2-4-21(19)28-10-9-20(22(28)29)26-13-18-12-25-15-27(18)14-17-7-5-16(11-24)6-8-17/h1-8,12,15,20,26H,9-10,13-14H2/t20-/m0/s1 DLASOUKHRBZNDA-FQEVSTJZSA-N 50103333 4-(5-{[1-(2-Chloro-phenyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL99381 Geranylgeranyl transferase type-1 subunit beta 42000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103333&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9931146 103999632 CHEMBL99381 ZINC53165445 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187374 O=C1[C@H](CCN1Cc1ccccc1)N(Cc1cncn1Cc1ccc(cc1)C#N)Cc1cccnc1 InChI=1S/C29H28N6O/c30-15-23-8-10-25(11-9-23)19-35-22-32-17-27(35)21-34(20-26-7-4-13-31-16-26)28-12-14-33(29(28)36)18-24-5-2-1-3-6-24/h1-11,13,16-17,22,28H,12,14,18-21H2/t28-/m0/s1 QFRFAEZUAFKYNV-NDEPHWFRSA-N 50103335 (S)-4-((5-(((1-benzyl-2-oxopyrrolidin-3-yl)(pyridin-3-ylmethyl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile::4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-pyridin-3-ylmethyl-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL327946 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103335&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10950878 103999634 CHEMBL327946 ZINC13863884 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187376 O=C1[C@@H](CCN1c1ccccc1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C22H21N5O/c23-12-17-6-8-18(9-7-17)15-26-16-24-13-20(26)14-25-21-10-11-27(22(21)28)19-4-2-1-3-5-19/h1-9,13,16,21,25H,10-11,14-15H2/t21-/m1/s1 JXSRHAPARDTOCD-OAQYLSRUSA-N 50103338 4-{5-[(2-Oxo-1-phenyl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL100230 Geranylgeranyl transferase type-1 subunit beta 41000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103338&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9885760 103999637 CHEMBL100230 ZINC13863845 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187379 Clc1cccc(c1)C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H22ClN5O/c24-20-3-1-2-19(10-20)23(30)28-9-8-21(15-28)27-13-22-12-26-16-29(22)14-18-6-4-17(11-25)5-7-18/h1-7,10,12,16,21,27H,8-9,13-15H2/t21-/m0/s1 MLRDIJRZSJTOLB-NRFANRHFSA-N 50103337 (S)-4-((5-((1-(3-chlorobenzoyl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile::4-(5-{[1-(3-Chloro-benzoyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL317520 Geranylgeranyl transferase type-1 subunit beta 11000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103337&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10895064 103999636 CHEMBL317520 ZINC13863867 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187381 Clc1cccc(CN2CC[C@H](N(CCN3CCOCC3)Cc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 InChI=1S/C29H33ClN6O2/c30-26-3-1-2-25(16-26)20-35-9-8-28(29(35)37)34(11-10-33-12-14-38-15-13-33)21-27-18-32-22-36(27)19-24-6-4-23(17-31)5-7-24/h1-7,16,18,22,28H,8-15,19-21H2/t28-/m0/s1 XEWSILGLGYHPRI-NDEPHWFRSA-N 50103334 4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-(2-morpholin-4-yl-ethyl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL100798 Geranylgeranyl transferase type-1 subunit beta 12000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103334&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9871743 103999633 CHEMBL100798 ZINC22449096 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187389 COc1ncccc1C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H24N6O2/c1-31-22-21(3-2-9-26-22)23(30)28-10-8-19(15-28)27-13-20-12-25-16-29(20)14-18-6-4-17(11-24)5-7-18/h2-7,9,12,16,19,27H,8,10,13-15H2,1H3/t19-/m0/s1 QHAPPAYFFDEACJ-IBGZPJMESA-N 50103344 4-(5-{[1-(2-Methoxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL101106 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103344&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10993420 103999643 CHEMBL101106 ZINC13863873 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187390 O=C1[C@H](CCN1c1ccncc1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C21H20N6O/c22-11-16-1-3-17(4-2-16)14-26-15-24-12-19(26)13-25-20-7-10-27(21(20)28)18-5-8-23-9-6-18/h1-6,8-9,12,15,20,25H,7,10,13-14H2/t20-/m0/s1 KDDZVJQCAMDQTB-FQEVSTJZSA-N 50103347 (S)-4-((5-((2-oxo-1-(pyridin-4-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile::4-{5-[(2-Oxo-1-pyridin-4-yl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL99371 Geranylgeranyl transferase type-1 subunit beta >20000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103347&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9842436 103999646 CHEMBL99371 ZINC13863862 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187392 O=C1[C@@H](CCN1Cc1ccccc1)NCCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C24H25N5O/c25-14-19-6-8-21(9-7-19)17-29-18-26-15-22(29)10-12-27-23-11-13-28(24(23)30)16-20-4-2-1-3-5-20/h1-9,15,18,23,27H,10-13,16-17H2/t23-/m1/s1 OVIRLMBMKPLLBQ-HSZRJFAPSA-N 50103348 4-{5-[2-(1-Benzyl-2-oxo-pyrrolidin-3-ylamino)-ethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL97973 Geranylgeranyl transferase type-1 subunit beta 11000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103348&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10960344 103999647 CHEMBL97973 ZINC13863853 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187393 NCCCN(Cc1cncn1Cc1ccc(cc1)C#N)[C@H]1CCN(Cc2cccc(Cl)c2)C1=O InChI=1S/C26H29ClN6O/c27-23-4-1-3-22(13-23)17-32-12-9-25(26(32)34)31(11-2-10-28)18-24-15-30-19-33(24)16-21-7-5-20(14-29)6-8-21/h1,3-8,13,15,19,25H,2,9-12,16-18,28H2/t25-/m0/s1 CDXIZXQBISVZMK-VWLOTQADSA-N 50103336 4-[5-({(3-Amino-propyl)-[1-(3-chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-amino}-methyl)-imidazol-1-ylmethyl]-benzonitrile::CHEMBL98147 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103336&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9912881 103999635 CHEMBL98147 ZINC13863885 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187394 Cc1ncccc1C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H24N6O/c1-17-22(3-2-9-26-17)23(30)28-10-8-20(15-28)27-13-21-12-25-16-29(21)14-19-6-4-18(11-24)5-7-19/h2-7,9,12,16,20,27H,8,10,13-15H2,1H3/t20-/m0/s1 DOPVMAHJUNWJJU-FQEVSTJZSA-N 50103324 4-(5-{[1-(2-Methyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL317129 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103324&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10949393 103999623 CHEMBL317129 ZINC13863870 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187396 O=C1[C@@H](CCN1CCc1ccccc1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C24H25N5O/c25-14-20-6-8-21(9-7-20)17-29-18-26-15-22(29)16-27-23-11-13-28(24(23)30)12-10-19-4-2-1-3-5-19/h1-9,15,18,23,27H,10-13,16-17H2/t23-/m1/s1 CFMXTSHLOSTNDP-HSZRJFAPSA-N 50103351 4-{5-[(2-Oxo-1-phenethyl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL100640 Geranylgeranyl transferase type-1 subunit beta 31000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103351&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11101410 103999650 CHEMBL100640 ZINC13863849 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187397 O=C1[C@H](CCN1c1cccc2ncccc12)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C25H22N6O/c26-13-18-6-8-19(9-7-18)16-30-17-27-14-20(30)15-29-23-10-12-31(25(23)32)24-5-1-4-22-21(24)3-2-11-28-22/h1-9,11,14,17,23,29H,10,12,15-16H2/t23-/m0/s1 BRCCXAUQKZKZAB-QHCPKHFHSA-N 50103352 (S)-4-((5-((2-oxo-1-(quinolin-5-yl)pyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile::4-{5-[(2-Oxo-1-quinolin-5-yl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL100566 Geranylgeranyl transferase type-1 subunit beta >20000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103352&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9866918 103999651 CHEMBL100566 ZINC13863863 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187399 Clc1ccccc1C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H22ClN5O/c24-22-4-2-1-3-21(22)23(30)28-10-9-19(15-28)27-13-20-12-26-16-29(20)14-18-7-5-17(11-25)6-8-18/h1-8,12,16,19,27H,9-10,13-15H2/t19-/m0/s1 IHJXPUJVCXRXDC-IBGZPJMESA-N 50103349 4-(5-{[1-(2-Chloro-benzoyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL101564 Geranylgeranyl transferase type-1 subunit beta 19000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103349&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11048052 103999648 CHEMBL101564 ZINC13863866 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187401 O=C(N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N)c1cccc2ccccc12 InChI=1S/C27H25N5O/c28-14-20-8-10-21(11-9-20)17-32-19-29-15-24(32)16-30-23-12-13-31(18-23)27(33)26-7-3-5-22-4-1-2-6-25(22)26/h1-11,15,19,23,30H,12-13,16-18H2/t23-/m0/s1 DIDRALNGAJEZDV-QHCPKHFHSA-N 50103331 4-(5-{[1-(Naphthalene-1-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL327278 Geranylgeranyl transferase type-1 subunit beta 880 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103331 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103331&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11091386 103999630 CHEMBL327278 ZINC13863865 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187405 O=C1[C@@H](CCN1c1ccccc1)NCCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H23N5O/c24-14-18-6-8-19(9-7-18)16-27-17-25-15-21(27)10-12-26-22-11-13-28(23(22)29)20-4-2-1-3-5-20/h1-9,15,17,22,26H,10-13,16H2/t22-/m1/s1 SBIMUGAYTIMITB-JOCHJYFZSA-N 50103353 4-{5-[2-(2-Oxo-1-phenyl-pyrrolidin-3-ylamino)-ethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL101978 Geranylgeranyl transferase type-1 subunit beta 16000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103353&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10916025 103999652 CHEMBL101978 ZINC13863851 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187412 O=C1[C@H](CCN1c1cccnc1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C21H20N6O/c22-10-16-3-5-17(6-4-16)14-26-15-24-12-19(26)13-25-20-7-9-27(21(20)28)18-2-1-8-23-11-18/h1-6,8,11-12,15,20,25H,7,9,13-14H2/t20-/m0/s1 ZRVKNPIDTYYJCE-FQEVSTJZSA-N 50103343 4-{5-[(2-Oxo-1-pyridin-3-yl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL99435 Geranylgeranyl transferase type-1 subunit beta >20000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103343&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9799609 103999642 CHEMBL99435 ZINC13863861 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187414 O=C(N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N)c1cccnc1 InChI=1S/C22H22N6O/c23-10-17-3-5-18(6-4-17)14-28-16-25-12-21(28)13-26-20-7-9-27(15-20)22(29)19-2-1-8-24-11-19/h1-6,8,11-12,16,20,26H,7,9,13-15H2/t20-/m0/s1 XNQGRIJQRDBCBM-FQEVSTJZSA-N 50103359 4-(5-{[1-(Pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL99650 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103359&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11728765 103999658 CHEMBL99650 ZINC13863869 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187416 NCCCN(Cc1cncn1Cc1ccc(cc1)C#N)[C@H]1CCN(Cc2ccccc2)C1=O InChI=1S/C26H30N6O/c27-12-4-13-30(25-11-14-31(26(25)33)17-22-5-2-1-3-6-22)19-24-16-29-20-32(24)18-23-9-7-21(15-28)8-10-23/h1-3,5-10,16,20,25H,4,11-14,17-19,27H2/t25-/m0/s1 NJRTXLQMEKTXLZ-VWLOTQADSA-N 50103350 (S)-4-((5-(((3-aminopropyl)(1-benzyl-2-oxopyrrolidin-3-yl)amino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile::4-(5-{[(3-Amino-propyl)-(1-benzyl-2-oxo-pyrrolidin-3-yl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL322007 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103350&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9824630 103999649 CHEMBL322007 ZINC13863883 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187417 O=C1[C@H](CCN1CCc1ccccc1)NCCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C25H27N5O/c26-16-21-6-8-22(9-7-21)18-30-19-27-17-23(30)10-13-28-24-12-15-29(25(24)31)14-11-20-4-2-1-3-5-20/h1-9,17,19,24,28H,10-15,18H2/t24-/m0/s1 ZFIIDVFVNVOHRN-DEOSSOPVSA-N 50103340 4-{5-[2-(2-Oxo-1-phenethyl-pyrrolidin-3-ylamino)-ethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL102107 Geranylgeranyl transferase type-1 subunit beta 2800 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103340&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11101729 103999639 CHEMBL102107 ZINC13863854 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187418 O=C1[C@@H](CCN1CCc1ccccc1)NCCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C25H27N5O/c26-16-21-6-8-22(9-7-21)18-30-19-27-17-23(30)10-13-28-24-12-15-29(25(24)31)14-11-20-4-2-1-3-5-20/h1-9,17,19,24,28H,10-15,18H2/t24-/m1/s1 ZFIIDVFVNVOHRN-XMMPIXPASA-N 50103341 4-{5-[2-(2-Oxo-1-phenethyl-pyrrolidin-3-ylamino)-ethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL317747 Geranylgeranyl transferase type-1 subunit beta 1500 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103341&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11004204 103999640 CHEMBL317747 ZINC13863855 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187425 O=C(N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N)c1ccccc1 InChI=1S/C23H23N5O/c24-12-18-6-8-19(9-7-18)15-28-17-25-13-22(28)14-26-21-10-11-27(16-21)23(29)20-4-2-1-3-5-20/h1-9,13,17,21,26H,10-11,14-16H2/t21-/m0/s1 LEBZYXLCZCFGKK-NRFANRHFSA-N 50103328 4-{5-[(1-Benzoyl-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL327506 Geranylgeranyl transferase type-1 subunit beta 24000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103328&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11025461 103999627 CHEMBL327506 ZINC13863864 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187426 CC(C)(C)OC(=O)NCCCN(Cc1cncn1Cc1ccc(cc1)C#N)[C@H]1CCN(Cc2cccc(Cl)c2)C1=O InChI=1S/C31H37ClN6O3/c1-31(2,3)41-30(40)35-13-5-14-36(28-12-15-37(29(28)39)20-25-6-4-7-26(32)16-25)21-27-18-34-22-38(27)19-24-10-8-23(17-33)9-11-24/h4,6-11,16,18,22,28H,5,12-15,19-21H2,1-3H3,(H,35,40)/t28-/m0/s1 GDPDFNXDSFOTHH-NDEPHWFRSA-N 50103360 (3-{[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-propyl)-carbamic acid tert-butyl ester::CHEMBL100661 Geranylgeranyl transferase type-1 subunit beta 2700 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103360&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10918896 103999659 CHEMBL100661 ZINC26748313 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187429 Clc1cccc(CN2CC[C@H](N(CCN3CCNCC3)Cc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 InChI=1S/C29H34ClN7O/c30-26-3-1-2-25(16-26)20-36-11-8-28(29(36)38)35(15-14-34-12-9-32-10-13-34)21-27-18-33-22-37(27)19-24-6-4-23(17-31)5-7-24/h1-7,16,18,22,28,32H,8-15,19-21H2/t28-/m0/s1 OAOZPXOXMVMQBZ-NDEPHWFRSA-N 50103346 4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-(2-piperazin-1-yl-ethyl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL101788 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103346&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9807068 103999645 CHEMBL101788 ZINC22941873 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187432 Clc1ccc(cc1)N1CC[C@H](NCc2cncn2Cc2ccc(cc2)C#N)C1=O InChI=1S/C22H20ClN5O/c23-18-5-7-19(8-6-18)28-10-9-21(22(28)29)26-13-20-12-25-15-27(20)14-17-3-1-16(11-24)2-4-17/h1-8,12,15,21,26H,9-10,13-14H2/t21-/m0/s1 JATLZNPDYCNKTL-NRFANRHFSA-N 50103321 4-(5-{[1-(4-Chloro-phenyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL101561 Geranylgeranyl transferase type-1 subunit beta 11000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103321&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9844227 103999620 CHEMBL101561 ZINC13863857 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187434 O=C1[C@H](CCN1Cc1ccccc1)NCCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C24H25N5O/c25-14-19-6-8-21(9-7-19)17-29-18-26-15-22(29)10-12-27-23-11-13-28(24(23)30)16-20-4-2-1-3-5-20/h1-9,15,18,23,27H,10-13,16-17H2/t23-/m0/s1 OVIRLMBMKPLLBQ-QHCPKHFHSA-N 50103329 4-{5-[2-(1-Benzyl-2-oxo-pyrrolidin-3-ylamino)-ethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL98314 Geranylgeranyl transferase type-1 subunit beta 7400 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103329&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10894628 103999628 CHEMBL98314 ZINC13863852 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187439 Nc1ncccc1C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C22H23N7O/c23-10-16-3-5-17(6-4-16)13-29-15-25-11-19(29)12-27-18-7-9-28(14-18)22(30)20-2-1-8-26-21(20)24/h1-6,8,11,15,18,27H,7,9,12-14H2,(H2,24,26)/t18-/m0/s1 FVDAOYOQPWBPHV-SFHVURJKSA-N 50103355 4-(5-{[1-(2-Amino-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL99323 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103355&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10938254 103999654 CHEMBL99323 ZINC13863871 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187441 O=C1[C@H](CCN1Cc1ccccc1)N(Cc1cncn1Cc1ccc(cc1)C#N)Cc1ccccc1 InChI=1S/C30H29N5O/c31-17-24-11-13-27(14-12-24)21-35-23-32-18-28(35)22-34(20-26-9-5-2-6-10-26)29-15-16-33(30(29)36)19-25-7-3-1-4-8-25/h1-14,18,23,29H,15-16,19-22H2/t29-/m0/s1 GCCKPAUGIAPVNW-LJAQVGFWSA-N 50103342 4-(5-{[Benzyl-(1-benzyl-2-oxo-pyrrolidin-3-yl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL101708 Geranylgeranyl transferase type-1 subunit beta 20000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103342&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11091976 103999641 CHEMBL101708 ZINC13863879 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187445 Brc1cncc(c1)C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C22H21BrN6O/c23-19-7-18(9-25-10-19)22(30)28-6-5-20(14-28)27-12-21-11-26-15-29(21)13-17-3-1-16(8-24)2-4-17/h1-4,7,9-11,15,20,27H,5-6,12-14H2/t20-/m0/s1 DXZIXKOCIQSMJW-FQEVSTJZSA-N 50103362 4-(5-{[1-(5-Bromo-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL98974 Geranylgeranyl transferase type-1 subunit beta 41000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103362&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10961614 103999661 CHEMBL98974 ZINC13863876 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187447 CSc1ncccc1C(=O)N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H24N6OS/c1-31-22-21(3-2-9-26-22)23(30)28-10-8-19(15-28)27-13-20-12-25-16-29(20)14-18-6-4-17(11-24)5-7-18/h2-7,9,12,16,19,27H,8,10,13-15H2,1H3/t19-/m0/s1 FPBHGUQIJSLDCS-IBGZPJMESA-N 50103363 4-(5-{[1-(2-Methylsulfanyl-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL319737 Geranylgeranyl transferase type-1 subunit beta 28000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103363&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10982914 103999662 CHEMBL319737 ZINC13863875 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187453 O=C(N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N)c1ccc[nH]c1=O InChI=1S/C22H22N6O2/c23-10-16-3-5-17(6-4-16)13-28-15-24-11-19(28)12-26-18-7-9-27(14-18)22(30)20-2-1-8-25-21(20)29/h1-6,8,11,15,18,26H,7,9,12-14H2,(H,25,29)/t18-/m0/s1 ZWDOEVOQPCCHJN-SFHVURJKSA-N 50103345 4-(5-{[1-(2-Hydroxy-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL101509 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103345&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11732162 103999644 CHEMBL101509 ZINC13863872 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187454 O=C(N1CC[C@@H](C1)NCc1cncn1Cc1ccc(cc1)C#N)c1ccc[nH]c1=S InChI=1S/C22H22N6OS/c23-10-16-3-5-17(6-4-16)13-28-15-24-11-19(28)12-26-18-7-9-27(14-18)22(29)20-2-1-8-25-21(20)30/h1-6,8,11,15,18,26H,7,9,12-14H2,(H,25,30)/t18-/m0/s1 QOXHIVVSKPCMNZ-SFHVURJKSA-N 50103364 4-(5-{[1-(2-Mercapto-pyridine-3-carbonyl)-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL430478 Geranylgeranyl transferase type-1 subunit beta >50000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103364 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103364&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10862667 103999663 CHEMBL430478 ZINC13863874 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187460 O=C1[C@H](CCN1Cc1ccccc1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H23N5O/c24-12-18-6-8-20(9-7-18)16-28-17-25-13-21(28)14-26-22-10-11-27(23(22)29)15-19-4-2-1-3-5-19/h1-9,13,17,22,26H,10-11,14-16H2/t22-/m0/s1 MRONYHYWJWVKKK-QFIPXVFZSA-N 50103354 (S)-4-((5-((1-benzyl-2-oxopyrrolidin-3-ylamino)methyl)-1H-imidazol-1-yl)methyl)benzonitrile::4-{5-[(1-Benzyl-2-oxo-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL316502 Geranylgeranyl transferase type-1 subunit beta 40000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103354&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9821510 103999653 CHEMBL316502 ZINC13863846 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187465 O=C1[C@H](CCN1Cc1ccccc1)N(CCCCc1ccccc1)Cc1cncn1Cc1ccc(cc1)C#N InChI=1S/C33H35N5O/c34-21-28-14-16-30(17-15-28)24-38-26-35-22-31(38)25-36(19-8-7-11-27-9-3-1-4-10-27)32-18-20-37(33(32)39)23-29-12-5-2-6-13-29/h1-6,9-10,12-17,22,26,32H,7-8,11,18-20,23-25H2/t32-/m0/s1 MLVPMWIOABZTQP-YTTGMZPUSA-N 50103357 4-(5-{[(1-Benzyl-2-oxo-pyrrolidin-3-yl)-(4-phenyl-butyl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL98711 Geranylgeranyl transferase type-1 subunit beta 4600 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103357&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9914569 103999656 CHEMBL98711 ZINC13863882 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187469 O=C1[C@@H](CCN1Cc1ccccc1)NCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H23N5O/c24-12-18-6-8-20(9-7-18)16-28-17-25-13-21(28)14-26-22-10-11-27(23(22)29)15-19-4-2-1-3-5-19/h1-9,13,17,22,26H,10-11,14-16H2/t22-/m1/s1 MRONYHYWJWVKKK-JOCHJYFZSA-N 50103358 4-{5-[(1-Benzyl-2-oxo-pyrrolidin-3-ylamino)-methyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL100579 Geranylgeranyl transferase type-1 subunit beta 46000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103358&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9952087 103999657 CHEMBL100579 ZINC13863847 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187472 Clc1cccc(CN2CC[C@H](N(CCCc3ccccc3)Cc3cncn3Cc3ccc(cc3)C#N)C2=O)c1 InChI=1S/C32H32ClN5O/c33-29-10-4-8-28(18-29)22-37-17-15-31(32(37)39)36(16-5-9-25-6-2-1-3-7-25)23-30-20-35-24-38(30)21-27-13-11-26(19-34)12-14-27/h1-4,6-8,10-14,18,20,24,31H,5,9,15-17,21-23H2/t31-/m0/s1 WASCAVIAFHINFK-HKBQPEDESA-N 50103322 4-(5-{[[1-(3-Chloro-benzyl)-2-oxo-pyrrolidin-3-yl]-(3-phenyl-propyl)-amino]-methyl}-imidazol-1-ylmethyl)-benzonitrile::CHEMBL316726 Geranylgeranyl transferase type-1 subunit beta 6500 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103322&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9915185 103999621 CHEMBL316726 ZINC26741671 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187476 CC(C)(C)OC(=O)NCCCN(Cc1cncn1Cc1ccc(cc1)C#N)[C@H]1CCN(Cc2ccccc2)C1=O InChI=1S/C31H38N6O3/c1-31(2,3)40-30(39)34-15-7-16-35(28-14-17-36(29(28)38)20-25-8-5-4-6-9-25)22-27-19-33-23-37(27)21-26-12-10-24(18-32)11-13-26/h4-6,8-13,19,23,28H,7,14-17,20-22H2,1-3H3,(H,34,39)/t28-/m0/s1 SLYBJCUKCICSBD-NDEPHWFRSA-N 50103356 (3-{(1-Benzyl-2-oxo-pyrrolidin-3-yl)-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-propyl)-carbamic acid tert-butyl ester::(S)-tert-butyl 3-((1-benzyl-2-oxopyrrolidin-3-yl)((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methyl)amino)propylcarbamate::CHEMBL98553 Geranylgeranyl transferase type-1 subunit beta 3600 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103356&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10896860 103999655 CHEMBL98553 ZINC26737429 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50187477 O=C1[C@H](CCN1c1ccccc1)NCCc1cncn1Cc1ccc(cc1)C#N InChI=1S/C23H23N5O/c24-14-18-6-8-19(9-7-18)16-27-17-25-15-21(27)10-12-26-22-11-13-28(23(22)29)20-4-2-1-3-5-20/h1-9,15,17,22,26H,10-13,16H2/t22-/m0/s1 SBIMUGAYTIMITB-QFIPXVFZSA-N 50103339 4-{5-[2-(2-Oxo-1-phenyl-pyrrolidin-3-ylamino)-ethyl]-imidazol-1-ylmethyl}-benzonitrile::CHEMBL418982 Geranylgeranyl transferase type-1 subunit beta 14000 ChEMBL 10.1021/jm010156p 10.7270/Q2FF3RNW 11520202 Bell, IM; Gallicchio, SN; Abrams, M; Beshore, DC; Buser, CA; Culberson, JC; Davide, J; Ellis-Hutchings, M; Fernandes, C; Gibbs, JB; Graham, SL; Hartman, GD; Heimbrook, DC; Homnick, CF; Huff, JR; Kassahun, K; Koblan, KS; Kohl, NE; Lobell, RB; Lynch, JJ; Miller, PA; Omer, CA; Rodrigues, AD; Walsh, ES; Williams, TM Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50103339&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 11111808 103999638 CHEMBL418982 ZINC13863850 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228584 Cn1cncc1C(O)(C#Cc1ccc(cc1-c1ccc2OCOc2c1)C#N)c1ccc(cc1)C#N InChI=1S/C28H18N4O3/c1-32-17-31-16-27(32)28(33,23-7-3-19(14-29)4-8-23)11-10-21-5-2-20(15-30)12-24(21)22-6-9-25-26(13-22)35-18-34-25/h2-9,12-13,16-17,33H,18H2,1H3 RXGGZGACWDLIGX-UHFFFAOYSA-N 50126026 3-Benzo[1,3]dioxol-5-yl-4-[3-(4-cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-benzonitrile::CHEMBL25620 Geranylgeranyl transferase type-1 subunit beta 5600 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126026&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44274782 104018169 CHEMBL25620 ZINC13488763 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228587 Cn1cncc1C(O)(C#Cc1ccc(cc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C27H16Cl2N4O/c1-33-17-32-16-26(33)27(34,22-6-3-18(14-30)4-7-22)9-8-20-5-2-19(15-31)10-25(20)21-11-23(28)13-24(29)12-21/h2-7,10-13,16-17,34H,1H3 PUBWKJYHDRHOJR-UHFFFAOYSA-N 50126028 3',5'-Dichloro-6-[3-(4-cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-biphenyl-3-carbonitrile::CHEMBL23578 Geranylgeranyl transferase type-1 subunit beta 1100 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126028&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9956928 104018171 CHEMBL23578 ZINC13488769 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228590 Cc1ccccc1-c1cc(ccc1C#N)C(O)(C#Cc1ccc(cc1)C#N)c1cncn1C InChI=1S/C28H20N4O/c1-20-5-3-4-6-25(20)26-15-24(12-11-23(26)17-30)28(33,27-18-31-19-32(27)2)14-13-21-7-9-22(16-29)10-8-21/h3-12,15,18-19,33H,1-2H3 DUORQQSLNAGSSQ-UHFFFAOYSA-N 50126032 5-[3-(4-Cyano-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2'-methyl-biphenyl-2-carbonitrile::CHEMBL282349 Geranylgeranyl transferase type-1 subunit beta 210 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126032&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44274804 104018175 CHEMBL282349 ZINC13488779 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228592 CCCCC(=O)c1ccc(C#CC(O)(c2cncn2C)c2ccc(cc2)C#N)c(c1)-c1cccc(OC)c1 InChI=1S/C32H29N3O3/c1-4-5-9-30(36)26-13-12-24(29(19-26)25-7-6-8-28(18-25)38-3)16-17-32(37,31-21-34-22-35(31)2)27-14-10-23(20-33)11-15-27/h6-8,10-15,18-19,21-22,37H,4-5,9H2,1-3H3 QMIGNVNXSVGBEL-UHFFFAOYSA-N 50126034 4-[1-Hydroxy-3-(3'-methoxy-5-pentanoyl-biphenyl-2-yl)-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile::CHEMBL26511 Geranylgeranyl transferase type-1 subunit beta >10000 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126034 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126034&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459924 104018177 CHEMBL26511 ZINC13488773 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228593 Cn1cncc1C(O)(C#Cc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(cc1)C#N InChI=1S/C28H17F3N4O2/c1-35-18-34-17-26(35)27(36,23-9-6-19(15-32)7-10-23)12-11-21-8-5-20(16-33)13-25(21)22-3-2-4-24(14-22)37-28(29,30)31/h2-10,13-14,17-18,36H,1H3 AQRLDBGCWSEIIY-UHFFFAOYSA-N 50126033 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-trifluoromethoxy-biphenyl-3-carbonitrile::CHEMBL24123 Geranylgeranyl transferase type-1 subunit beta 430 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126033 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126033&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459504 104018176 CHEMBL24123 ZINC13488767 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228594 Cc1ccc(cn1)C#CC(O)(c1cncn1C)c1ccc(C#N)c(c1)-c1cccc2ccccc12 InChI=1S/C30H22N4O/c1-21-10-11-22(18-33-21)14-15-30(35,29-19-32-20-34(29)2)25-13-12-24(17-31)28(16-25)27-9-5-7-23-6-3-4-8-26(23)27/h3-13,16,18-20,35H,1-2H3 NAEYWVZYJOIXPA-UHFFFAOYSA-N 50126037 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(6-methyl-pyridin-3-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL23753 Geranylgeranyl transferase type-1 subunit beta 40 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126037 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126037&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459321 104018180 CHEMBL23753 ZINC13488757 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228602 COc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N InChI=1S/C28H20N4O2/c1-32-19-31-18-27(32)28(33,24-10-7-20(16-29)8-11-24)13-12-22-9-6-21(17-30)14-26(22)23-4-3-5-25(15-23)34-2/h3-11,14-15,18-19,33H,1-2H3 XWDXWBALIUAPLO-UHFFFAOYSA-N 50126041 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3''-methoxy-biphenyl-3-carbonitrile::6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-methoxy-biphenyl-3-carbonitrile::CHEMBL22702 Geranylgeranyl transferase type-1 subunit beta 4100 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126041&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459509 104018184 CHEMBL22702 ZINC13488761 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228607 CCc1ccc(cc1)C#CC(O)(c1cncn1C)c1ccc(C#N)c(c1)-c1cccc2ccccc12 InChI=1S/C32H25N3O/c1-3-23-11-13-24(14-12-23)17-18-32(36,31-21-34-22-35(31)2)27-16-15-26(20-33)30(19-27)29-10-6-8-25-7-4-5-9-28(25)29/h4-16,19,21-22,36H,3H2,1-2H3 VSZXKSCVZMOQFB-UHFFFAOYSA-N 50126031 4-[3-(4-Ethyl-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL23370 Geranylgeranyl transferase type-1 subunit beta 18 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126031&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459100 104018174 CHEMBL23370 ZINC13488753 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228609 Cn1cncc1C(O)(C#Cc1ccccc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 InChI=1S/C30H21N3O/c1-33-21-32-20-29(33)30(34,17-16-22-8-3-2-4-9-22)25-15-14-24(19-31)28(18-25)27-13-7-11-23-10-5-6-12-26(23)27/h2-15,18,20-21,34H,1H3 GTURWVWPNOUBNH-UHFFFAOYSA-N 50126030 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL24271 Geranylgeranyl transferase type-1 subunit beta 3.1 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126030 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126030&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459775 104018173 CHEMBL24271 ZINC13488741 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228610 Cn1cncc1C(O)(C#Cc1ccc(cc1)C#C)c1ccc(C#N)c(c1)-c1cccc2ccccc12 InChI=1S/C32H21N3O/c1-3-23-11-13-24(14-12-23)17-18-32(36,31-21-34-22-35(31)2)27-16-15-26(20-33)30(19-27)29-10-6-8-25-7-4-5-9-28(25)29/h1,4-16,19,21-22,36H,2H3 OAEIWTGUZXTPAT-UHFFFAOYSA-N 50126027 4-[3-(4-Ethynyl-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL24554 Geranylgeranyl transferase type-1 subunit beta 16 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126027&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459847 104018170 CHEMBL24554 ZINC13488747 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228614 Cc1ccccc1-c1cc(ccc1C#N)C(O)(C#Cc1ccccc1)c1cncn1C InChI=1S/C27H21N3O/c1-20-8-6-7-11-24(20)25-16-23(13-12-22(25)17-28)27(31,26-18-29-19-30(26)2)15-14-21-9-4-3-5-10-21/h3-13,16,18-19,31H,1-2H3 TXMWWHNPHYEWNP-UHFFFAOYSA-N 50126029 5-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-prop-2-ynyl]-2'-methyl-biphenyl-2-carbonitrile::CHEMBL24822 Geranylgeranyl transferase type-1 subunit beta 240 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126029&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44274806 104018172 CHEMBL24822 ZINC13488777 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228617 Cc1ccccc1-c1cc(ccc1C#N)C(O)(c1cncn1C)c1ccc(cc1)C#N InChI=1S/C26H20N4O/c1-18-5-3-4-6-23(18)24-13-22(12-9-20(24)15-28)26(31,25-16-29-17-30(25)2)21-10-7-19(14-27)8-11-21/h3-13,16-17,31H,1-2H3 KKJPSAVOCOHZGT-UHFFFAOYSA-N 50126044 5-[(4-Cyano-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-2'-methyl-biphenyl-2-carbonitrile::CHEMBL25621 Geranylgeranyl transferase type-1 subunit beta 1200 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126044 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126044&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44274783 104018187 CHEMBL25621 ZINC13488781 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228618 Cn1cncc1C(O)(C#Cc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 InChI=1S/C31H20N4O/c1-35-21-34-20-30(35)31(36,16-15-22-9-11-23(18-32)12-10-22)26-14-13-25(19-33)29(17-26)28-8-4-6-24-5-2-3-7-27(24)28/h2-14,17,20-21,36H,1H3 DOZZPCQVJJBKME-UHFFFAOYSA-N 50126035 4-[3-(4-Cyano-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL24733 Geranylgeranyl transferase type-1 subunit beta 10 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126035&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44274781 104018178 CHEMBL24733 ZINC13488755 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228619 COc1cccc(c1)-c1cc(Cl)ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N InChI=1S/C27H20ClN3O2/c1-31-18-30-17-26(31)27(32,22-9-6-19(16-29)7-10-22)13-12-20-8-11-23(28)15-25(20)21-4-3-5-24(14-21)33-2/h3-11,14-15,17-18,32H,1-2H3 HRCUJSFALQORGR-UHFFFAOYSA-N 50126042 4-[3-(5-Chloro-3'-methoxy-biphenyl-2-yl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile::CHEMBL26068 Geranylgeranyl transferase type-1 subunit beta 740 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126042 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126042&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459344 104018185 CHEMBL26068 ZINC13488771 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228621 Cn1cncc1C(O)(C#Cc1ccc(Cl)cc1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 InChI=1S/C30H20ClN3O/c1-34-20-33-19-29(34)30(35,16-15-21-9-13-25(31)14-10-21)24-12-11-23(18-32)28(17-24)27-8-4-6-22-5-2-3-7-26(22)27/h2-14,17,19-20,35H,1H3 RHTSWGZKPCQUKZ-UHFFFAOYSA-N 50126045 4-[3-(4-Chloro-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL283051 Geranylgeranyl transferase type-1 subunit beta 9.5 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126045 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126045&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459819 104018188 CHEMBL283051 ZINC13488743 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228624 CCCCCc1ccc(cc1)C#CC(O)(c1cncn1C)c1ccc(C#N)c(c1)-c1cccc2ccccc12 InChI=1S/C35H31N3O/c1-3-4-5-9-26-14-16-27(17-15-26)20-21-35(39,34-24-37-25-38(34)2)30-19-18-29(23-36)33(22-30)32-13-8-11-28-10-6-7-12-31(28)32/h6-8,10-19,22,24-25,39H,3-5,9H2,1-2H3 RLZPEQLIWYHFHH-UHFFFAOYSA-N 50126039 4-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-(4-pentyl-phenyl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL24048 Geranylgeranyl transferase type-1 subunit beta 360 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126039&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459799 104018182 CHEMBL24048 ZINC13488749 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228629 CCOc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N InChI=1S/C29H22N4O2/c1-3-35-26-6-4-5-24(16-26)27-15-22(18-31)7-10-23(27)13-14-29(34,28-19-32-20-33(28)2)25-11-8-21(17-30)9-12-25/h4-12,15-16,19-20,34H,3H2,1-2H3 QYLBZDCYGRTUQE-UHFFFAOYSA-N 50126036 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3''-ethoxy-biphenyl-3-carbonitrile::6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-ethoxy-biphenyl-3-carbonitrile::CHEMBL24043 Geranylgeranyl transferase type-1 subunit beta 2400 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126036&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459594 104018179 CHEMBL24043 ZINC13488765 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228631 Cn1cncc1C(O)(C#Cc1cccc(N)c1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 InChI=1S/C30H22N4O/c1-34-20-33-19-29(34)30(35,15-14-21-6-4-9-25(32)16-21)24-13-12-23(18-31)28(17-24)27-11-5-8-22-7-2-3-10-26(22)27/h2-13,16-17,19-20,35H,32H2,1H3 ZPHPMNJCCXXCGX-UHFFFAOYSA-N 50126043 4-[3-(3-Amino-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-naphthalen-1-yl-benzonitrile::CHEMBL418018 Geranylgeranyl transferase type-1 subunit beta 92 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126043 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126043&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459853 104018186 CHEMBL418018 ZINC13488745 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228632 COc1cccc(c1)-c1cc(ccc1CCC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N InChI=1S/C28H24N4O2/c1-32-19-31-18-27(32)28(33,24-10-7-20(16-29)8-11-24)13-12-22-9-6-21(17-30)14-26(22)23-4-3-5-25(15-23)34-2/h3-11,14-15,18-19,33H,12-13H2,1-2H3 MRIIEPZJIMUDLC-UHFFFAOYSA-N 50126040 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-propyl]-3'-methoxy-biphenyl-3-carbonitrile::CHEMBL22703 Geranylgeranyl transferase type-1 subunit beta 870 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126040&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459510 104018183 CHEMBL22703 ZINC13488783 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228639 Cn1cncc1C(O)(C#Cc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2cccnc12 InChI=1S/C30H19N5O/c1-35-20-33-19-28(35)30(36,14-13-21-7-9-22(17-31)10-8-21)25-12-11-24(18-32)27(16-25)26-6-2-4-23-5-3-15-34-29(23)26/h2-12,15-16,19-20,36H,1H3 OCGBVMDVBLYKEO-UHFFFAOYSA-N 50126025 4-[3-(4-Cyano-phenyl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-2-quinolin-8-yl-benzonitrile::CHEMBL24159 Geranylgeranyl transferase type-1 subunit beta 83000 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126025&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459800 104018168 CHEMBL24159 ZINC13488751 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228640 Cn1cncc1C(O)(C#Cc1ccc(Cl)cc1-c1cccc(Cl)c1)c1ccc(cc1)C#N InChI=1S/C26H17Cl2N3O/c1-31-17-30-16-25(31)26(32,21-8-5-18(15-29)6-9-21)12-11-19-7-10-23(28)14-24(19)20-3-2-4-22(27)13-20/h2-10,13-14,16-17,32H,1H3 AYVGITDSDRJQKI-UHFFFAOYSA-N 50126024 4-[3-(5,3'-Dichloro-biphenyl-2-yl)-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile::CHEMBL277646 Geranylgeranyl transferase type-1 subunit beta 100 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126024&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 17965976 104018167 CHEMBL277646 ZINC13488759 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50228642 Cc1ccccc1-c1cc(ccc1C#N)C(O)(CCc1ccccc1)c1cncn1C InChI=1S/C27H25N3O/c1-20-8-6-7-11-24(20)25-16-23(13-12-22(25)17-28)27(31,26-18-29-19-30(26)2)15-14-21-9-4-3-5-10-21/h3-13,16,18-19,31H,14-15H2,1-2H3 SEZMKJCYZBSCJV-UHFFFAOYSA-N 50126038 5-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-propyl]-2'-methyl-biphenyl-2-carbonitrile::CHEMBL26492 Geranylgeranyl transferase type-1 subunit beta 1800 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126038 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126038&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44274825 104018181 CHEMBL26492 ZINC13488775 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231049 Cn1cncc1C(OCc1ccc(cc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(nc1)C#N InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-24(32)25(17-4-5-22(11-29)31-12-17)33-14-18-3-2-16(10-28)6-23(18)19-7-20(26)9-21(27)8-19/h2-9,12-13,15,25H,14H2,1H3 AGXJJWJDXVZXBF-UHFFFAOYSA-N 50127300 5-[(3',5'-Dichloro-5-cyano-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile::CHEMBL289844 Geranylgeranyl transferase type-1 subunit beta 960 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127300 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127300&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286957 104019192 CHEMBL289844 ZINC13489589 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50594283 COc1cccc(c1)-c1cc(ccc1C#CC(O)(c1cncn1C)c1ccc(cc1)C#N)C#N InChI=1S/C28H20N4O2/c1-32-19-31-18-27(32)28(33,24-10-7-20(16-29)8-11-24)13-12-22-9-6-21(17-30)14-26(22)23-4-3-5-25(15-23)34-2/h3-11,14-15,18-19,33H,1-2H3 XWDXWBALIUAPLO-UHFFFAOYSA-N 50126041 6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3''-methoxy-biphenyl-3-carbonitrile::6-[3-(4-Cyano-phenyl)-3-hydroxy-3-(3-methyl-3H-imidazol-4-yl)-prop-1-ynyl]-3'-methoxy-biphenyl-3-carbonitrile::CHEMBL22702 Geranylgeranyl transferase type-1 subunit beta 4100 ChEMBL 10.1016/s0960-894x(03)00122-7 10.7270/Q2DV1J8J 12657267 Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50126041 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50126041&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44459509 104018184 CHEMBL22702 ZINC13488761 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231051 Cn1cncc1C(OCc1nc(Cl)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-23(32)24(17-7-5-16(11-28)6-8-17)33-14-22-21(10-19(12-29)25(27)31-22)18-3-2-4-20(26)9-18/h2-10,13,15,24H,14H2,1H3 JVWHVGIRXILXMU-UHFFFAOYSA-N 50127302 2-Chloro-5-(3-chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile::CHEMBL288046 Geranylgeranyl transferase type-1 subunit beta 2800 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127302&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 2C5 1NI1 44286298 104019194 CHEMBL288046 ZINC13489607 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231055 Cn1cncc1C(OCc1ccc(cc1-c1cccc2ccccc12)C#N)c1ccc(nc1)C#N InChI=1S/C29H21N5O/c1-34-19-32-17-28(34)29(22-11-12-24(15-31)33-16-22)35-18-23-10-9-20(14-30)13-27(23)26-8-4-6-21-5-2-3-7-25(21)26/h2-13,16-17,19,29H,18H2,1H3 SLDJKNOZEFXLPZ-UHFFFAOYSA-N 50127308 5-[(4-Cyano-2-naphthalen-1-yl-benzyloxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile::CHEMBL287729 Geranylgeranyl transferase type-1 subunit beta >10 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127308 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127308&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286737 104019200 CHEMBL287729 ZINC13489591 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231056 Cn1cncc1C(OCc1nc(N2CCN(CC2)C(=O)OC(C)(C)C)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C34H34ClN7O3/c1-34(2,3)45-33(43)42-14-12-41(13-15-42)32-26(19-37)17-28(25-6-5-7-27(35)16-25)29(39-32)21-44-31(30-20-38-22-40(30)4)24-10-8-23(18-36)9-11-24/h5-11,16-17,20,22,31H,12-15,21H2,1-4H3 CTLODRUWNFPOBN-UHFFFAOYSA-N 50127307 4-{5-(3-Chloro-phenyl)-3-cyano-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-pyridin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester::CHEMBL41936 Geranylgeranyl transferase type-1 subunit beta 650 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127307 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127307&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286282 104019199 CHEMBL41936 ZINC29341201 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231060 Cn1cncc1C(OCc1ccc(cc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(nc1)C#N InChI=1S/C26H18F3N5O2/c1-34-16-32-14-24(34)25(19-7-8-21(12-31)33-13-19)35-15-20-6-5-17(11-30)9-23(20)18-3-2-4-22(10-18)36-26(27,28)29/h2-10,13-14,16,25H,15H2,1H3 ZCOVCZOOFBWXSI-UHFFFAOYSA-N 50127306 5-[(5-Cyano-3'-trifluoromethoxy-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile::CHEMBL38615 Geranylgeranyl transferase type-1 subunit beta 990 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127306 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127306&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286801 104019198 CHEMBL38615 ZINC13489581 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231062 CC(=O)N1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc1C#N)-c1cccc(Cl)c1 InChI=1S/C31H28ClN7O2/c1-21(40)38-10-12-39(13-11-38)31-25(17-34)15-27(24-4-3-5-26(32)14-24)28(36-31)19-41-30(29-18-35-20-37(29)2)23-8-6-22(16-33)7-9-23/h3-9,14-15,18,20,30H,10-13,19H2,1-2H3 NSUUDAUUQPVPAO-UHFFFAOYSA-N 50127317 2-(4-Acetyl-piperazin-1-yl)-5-(3-chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile::CHEMBL39805 Geranylgeranyl transferase type-1 subunit beta 2100 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127317 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127317&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286315 104019209 CHEMBL39805 ZINC29326633 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231064 Cn1cncc1C(OCc1ccc(cc1-c1ccc2OCOc2c1)C#N)c1ccc(nc1)C#N InChI=1S/C26H19N5O3/c1-31-15-29-13-23(31)26(19-4-6-21(11-28)30-12-19)32-14-20-3-2-17(10-27)8-22(20)18-5-7-24-25(9-18)34-16-33-24/h2-9,12-13,15,26H,14,16H2,1H3 RGMYZJYRYHPFBW-UHFFFAOYSA-N 50127319 5-[(2-Benzo[1,3]dioxol-5-yl-4-cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile::CHEMBL288449 Geranylgeranyl transferase type-1 subunit beta >10 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127319 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127319&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286942 104019211 CHEMBL288449 ZINC13489583 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231065 Cn1cncc1C(OCc1nc(N2CCC(O)CC2)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C30H27ClN6O2/c1-36-19-34-17-28(36)29(21-7-5-20(15-32)6-8-21)39-18-27-26(22-3-2-4-24(31)13-22)14-23(16-33)30(35-27)37-11-9-25(38)10-12-37/h2-8,13-14,17,19,25,29,38H,9-12,18H2,1H3 GIJSSZXEWXNRRC-UHFFFAOYSA-N 50127320 5'-(3-Chloro-phenyl)-6'-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-carbonitrile::CHEMBL38941 Geranylgeranyl transferase type-1 subunit beta 830 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127320&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286755 104019212 CHEMBL38941 ZINC29338094 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231066 Cn1cncc1C(OCc1ccc(nc1-c1ccc2OC(F)(F)Oc2c1)C#N)c1ccc(cc1)C#N InChI=1S/C26H17F2N5O3/c1-33-15-31-13-21(33)25(17-4-2-16(11-29)3-5-17)34-14-19-6-8-20(12-30)32-24(19)18-7-9-22-23(10-18)36-26(27,28)35-22/h2-10,13,15,25H,14H2,1H3 ZIBOWPSGINTRQG-UHFFFAOYSA-N 50127321 5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-(2,2-difluoro-benzo[1,3]dioxol-5-yl)-pyridine-2-carbonitrile::CHEMBL41951 Geranylgeranyl transferase type-1 subunit beta 1100 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127321 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127321&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10206356 104019213 CHEMBL41951 ZINC11687758 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231069 Cn1cncc1C(OCc1ncc(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C25H18ClN5O/c1-31-16-29-14-24(31)25(19-7-5-17(11-27)6-8-19)32-15-23-22(9-18(12-28)13-30-23)20-3-2-4-21(26)10-20/h2-10,13-14,16,25H,15H2,1H3 QMHTYBBGJXNNQH-UHFFFAOYSA-N 50127316 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile::CHEMBL39117 Geranylgeranyl transferase type-1 subunit beta 4200 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127316 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127316&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286300 104019208 CHEMBL39117 ZINC13489605 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231070 Cn1cncc1C(OCc1ccc(cn1)C#N)c1ccc(C#N)c(c1)-c1cccc2ccccc12 InChI=1S/C29H21N5O/c1-34-19-32-17-28(34)29(35-18-24-12-9-20(14-30)16-33-24)22-10-11-23(15-31)27(13-22)26-8-4-6-21-5-2-3-7-25(21)26/h2-13,16-17,19,29H,18H2,1H3 ACXPVQQIYOUAGF-UHFFFAOYSA-N 50127315 6-[(4-Cyano-3-naphthalen-1-yl-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile::A-315493::CHEMBL43631 Geranylgeranyl transferase type-1 subunit beta 24 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127315 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127315&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 9846821 104019207 CHEMBL43631 ZINC13489573 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231071 Cn1cncc1C(OCc1ccc(nc1-c1cc(F)cc(F)c1)C#N)c1ccc(cc1)C#N InChI=1S/C25H17F2N5O/c1-32-15-30-13-23(32)25(17-4-2-16(11-28)3-5-17)33-14-18-6-7-22(12-29)31-24(18)19-8-20(26)10-21(27)9-19/h2-10,13,15,25H,14H2,1H3 PNGSJEMFIGGIGE-UHFFFAOYSA-N 50127322 5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-(3,5-difluoro-phenyl)-pyridine-2-carbonitrile::CHEMBL43082 Geranylgeranyl transferase type-1 subunit beta 4800 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127322 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127322&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10138186 104019214 CHEMBL43082 ZINC13489619 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231072 CN1CCN(CC1)c1nc(COC(c2cncn2C)c2ccc(cc2)C#N)c(cc1C#N)-c1cccc(Cl)c1 InChI=1S/C30H28ClN7O/c1-36-10-12-38(13-11-36)30-24(17-33)15-26(23-4-3-5-25(31)14-23)27(35-30)19-39-29(28-18-34-20-37(28)2)22-8-6-21(16-32)7-9-22/h3-9,14-15,18,20,29H,10-13,19H2,1-2H3 KFYACKONMAAENB-UHFFFAOYSA-N 50127304 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-2-(4-methyl-piperazin-1-yl)-nicotinonitrile::CHEMBL290760 Geranylgeranyl transferase type-1 subunit beta 2400 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127304&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286345 104019196 CHEMBL290760 ZINC29340224 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231075 Cn1cncc1C(OCc1nc(N2CCC(CC2)C(N)=O)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C31H28ClN7O2/c1-38-19-36-17-28(38)29(21-7-5-20(15-33)6-8-21)41-18-27-26(23-3-2-4-25(32)13-23)14-24(16-34)31(37-27)39-11-9-22(10-12-39)30(35)40/h2-8,13-14,17,19,22,29H,9-12,18H2,1H3,(H2,35,40) JUYGKHWFFVPZSG-UHFFFAOYSA-N 50127301 5'-(3-Chloro-phenyl)-3'-cyano-6'-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-carboxylic acid amide::CHEMBL288901 Geranylgeranyl transferase type-1 subunit beta 2100 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127301 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127301&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286768 104019193 CHEMBL288901 ZINC29337227 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231077 Cn1cncc1C(OCc1ccc(nc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C25H18ClN5O/c1-31-16-29-14-23(31)25(18-7-5-17(12-27)6-8-18)32-15-20-9-10-22(13-28)30-24(20)19-3-2-4-21(26)11-19/h2-11,14,16,25H,15H2,1H3 DYDSFPPSNIDLGG-UHFFFAOYSA-N 50127312 6-(3-Chloro-phenyl)-5-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-pyridine-2-carbonitrile::CHEMBL38438 Geranylgeranyl transferase type-1 subunit beta 1700 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127312 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127312&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286765 104019204 CHEMBL38438 ZINC13489613 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231079 Cn1cncc1C(OCc1ccc(C#N)c(n1)-c1ccc(Cl)c(Cl)c1)c1ccc(cc1)C#N InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-23(32)25(17-4-2-16(11-28)3-5-17)33-14-20-8-6-19(12-29)24(31-20)18-7-9-21(26)22(27)10-18/h2-10,13,15,25H,14H2,1H3 OFHZJNIDVREURX-UHFFFAOYSA-N 50127326 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-2-(3,4-dichloro-phenyl)-nicotinonitrile::CHEMBL38567 Geranylgeranyl transferase type-1 subunit beta 1600 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127326 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127326&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286579 104019218 CHEMBL38567 ZINC29334293 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231081 COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(nc1)C#N)C#N InChI=1S/C26H21N5O2/c1-31-17-29-15-25(31)26(20-8-9-22(13-28)30-14-20)33-16-21-7-6-18(12-27)10-24(21)19-4-3-5-23(11-19)32-2/h3-11,14-15,17,26H,16H2,1-2H3 CCEZIQLQUIJUBR-UHFFFAOYSA-N 50127314 5-[(5-Cyano-3'-methoxy-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile::CHEMBL432477 Geranylgeranyl transferase type-1 subunit beta >10 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127314 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127314&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286656 104019206 CHEMBL432477 ZINC13489579 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231082 Cn1cncc1C(OCc1ccc(nc1-c1ccc(OC(F)(F)F)cc1)C#N)c1ccc(cc1)C#N InChI=1S/C26H18F3N5O2/c1-34-16-32-14-23(34)25(19-4-2-17(12-30)3-5-19)35-15-20-6-9-21(13-31)33-24(20)18-7-10-22(11-8-18)36-26(27,28)29/h2-11,14,16,25H,15H2,1H3 PRTIQKLSEBTSEX-UHFFFAOYSA-N 50127311 5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-(4-trifluoromethoxy-phenyl)-pyridine-2-carbonitrile::CHEMBL39096 Geranylgeranyl transferase type-1 subunit beta 1200 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127311 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127311&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286376 104019203 CHEMBL39096 ZINC13489617 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231083 Cn1cncc1C(OCc1ccc(nc1-c1cccc(OC(F)(F)F)c1)C#N)c1ccc(cc1)C#N InChI=1S/C26H18F3N5O2/c1-34-16-32-14-23(34)25(18-7-5-17(12-30)6-8-18)35-15-20-9-10-21(13-31)33-24(20)19-3-2-4-22(11-19)36-26(27,28)29/h2-11,14,16,25H,15H2,1H3 IXSAIGOWYFZUSH-UHFFFAOYSA-N 50127313 5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-(3-trifluoromethoxy-phenyl)-pyridine-2-carbonitrile::CHEMBL37194 Geranylgeranyl transferase type-1 subunit beta 510 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127313 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127313&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286420 104019205 CHEMBL37194 ZINC13489615 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231085 Cn1cncc1C(OCc1ccc(nc1-c1cc(Cl)cc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C25H17Cl2N5O/c1-32-15-30-13-23(32)25(17-4-2-16(11-28)3-5-17)33-14-18-6-7-22(12-29)31-24(18)19-8-20(26)10-21(27)9-19/h2-10,13,15,25H,14H2,1H3 YPXXJOQZHCVTGX-UHFFFAOYSA-N 50127324 5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-(3,5-dichloro-phenyl)-pyridine-2-carbonitrile::CHEMBL41268 Geranylgeranyl transferase type-1 subunit beta 1400 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127324 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127324&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286733 104019216 CHEMBL41268 ZINC13489621 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231088 Cn1cncc1C(OCc1nc(N2CCOCC2)c(cc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C29H25ClN6O2/c1-35-19-33-17-27(35)28(21-7-5-20(15-31)6-8-21)38-18-26-25(22-3-2-4-24(30)13-22)14-23(16-32)29(34-26)36-9-11-37-12-10-36/h2-8,13-14,17,19,28H,9-12,18H2,1H3 RTLDRWAPUHCBNP-UHFFFAOYSA-N 50127318 5-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-2-morpholin-4-yl-nicotinonitrile::CHEMBL434396 Geranylgeranyl transferase type-1 subunit beta 1800 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127318 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127318&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286780 104019210 CHEMBL434396 ZINC13489609 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231089 Cn1cncc1C(OCc1cc(ncc1-c1cccc(Cl)c1)C#N)c1ccc(cc1)C#N InChI=1S/C25H18ClN5O/c1-31-16-29-14-24(31)25(18-7-5-17(11-27)6-8-18)32-15-20-10-22(12-28)30-13-23(20)19-3-2-4-21(26)9-19/h2-10,13-14,16,25H,15H2,1H3 HKVTXPJKYGMKNK-UHFFFAOYSA-N 50127328 5-(3-Chloro-phenyl)-4-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-pyridine-2-carbonitrile::CHEMBL288838 Geranylgeranyl transferase type-1 subunit beta >10 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127328&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286646 104019220 CHEMBL288838 ZINC29336753 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231092 Cn1cncc1C(OCc1ccc(cc1)C#N)c1ccc(C#N)c(c1)-c1cccc2cccnc12 InChI=1S/C29H21N5O/c1-34-19-32-17-27(34)29(35-18-21-9-7-20(15-30)8-10-21)23-11-12-24(16-31)26(14-23)25-6-2-4-22-5-3-13-33-28(22)25/h2-14,17,19,29H,18H2,1H3 XFFMOMTYXRNGLF-UHFFFAOYSA-N 50127329 4-[(4-Cyano-benzyloxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-2-quinolin-8-yl-benzonitrile::CHEMBL38595 Geranylgeranyl transferase type-1 subunit beta 103 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127329 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127329&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286776 104019221 CHEMBL38595 ZINC13489571 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231093 Cn1cncc1C(OCc1ccc(cc1-c1ccc(F)c(Cl)c1)C#N)c1ccc(nc1)C#N InChI=1S/C25H17ClFN5O/c1-32-15-30-13-24(32)25(18-4-6-20(11-29)31-12-18)33-14-19-3-2-16(10-28)8-21(19)17-5-7-23(27)22(26)9-17/h2-9,12-13,15,25H,14H2,1H3 XBLAJQIOYXLORX-UHFFFAOYSA-N 50127303 5-[(3'-Chloro-5-cyano-4'-fluoro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile::CHEMBL41682 Geranylgeranyl transferase type-1 subunit beta 8600 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127303 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127303&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286959 104019195 CHEMBL41682 ZINC13489585 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231096 Cn1cncc1C(OCc1ccc(C#N)c(n1)-c1ccc(Cl)cc1)c1ccc(cc1)C#N InChI=1S/C25H18ClN5O/c1-31-16-29-14-23(31)25(19-4-2-17(12-27)3-5-19)32-15-22-11-8-20(13-28)24(30-22)18-6-9-21(26)10-7-18/h2-11,14,16,25H,15H2,1H3 JRBAIZPPQGWCJN-UHFFFAOYSA-N 50127327 2-(4-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile::CHEMBL418059 Geranylgeranyl transferase type-1 subunit beta 3900 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127327 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127327&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286332 104019219 CHEMBL418059 ZINC13489601 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231099 Cn1cncc1C(OCc1ccc(nc1-c1ccccc1)C#N)c1ccc(cc1)C#N InChI=1S/C25H19N5O/c1-30-17-28-15-23(30)25(20-9-7-18(13-26)8-10-20)31-16-21-11-12-22(14-27)29-24(21)19-5-3-2-4-6-19/h2-12,15,17,25H,16H2,1H3 UGQZHVGAYVWKBH-UHFFFAOYSA-N 50127305 5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-phenyl-pyridine-2-carbonitrile::CHEMBL41540 Geranylgeranyl transferase type-1 subunit beta >10 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127305 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127305&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286767 104019197 CHEMBL41540 ZINC13489611 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231101 Cn1cncc1C(OCc1ccc(cc1-c1cc(F)cc(F)c1)C#N)c1ccc(nc1)C#N InChI=1S/C25H17F2N5O/c1-32-15-30-13-24(32)25(17-4-5-22(11-29)31-12-17)33-14-18-3-2-16(10-28)6-23(18)19-7-20(26)9-21(27)8-19/h2-9,12-13,15,25H,14H2,1H3 NMODPAHHKRMSIL-UHFFFAOYSA-N 50127299 5-[(5-Cyano-3',5'-difluoro-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile::CHEMBL41454 Geranylgeranyl transferase type-1 subunit beta >10 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127299&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286958 104019191 CHEMBL41454 ZINC13489587 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231103 Cn1cncc1C(OCc1ccc(nc1N1CCN(CC1)C(=O)OC(C)(C)C)C#N)c1ccc(cc1)C#N InChI=1S/C28H31N7O3/c1-28(2,3)38-27(36)35-13-11-34(12-14-35)26-22(9-10-23(16-30)32-26)18-37-25(24-17-31-19-33(24)4)21-7-5-20(15-29)6-8-21/h5-10,17,19,25H,11-14,18H2,1-4H3 BLLWRZKPPHTMHT-UHFFFAOYSA-N 50127309 4-{6-Cyano-3-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-pyridin-2-yl}-piperazine-1-carboxylic acid tert-butyl ester::CHEMBL41518 Geranylgeranyl transferase type-1 subunit beta 42 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127309&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286732 104019201 CHEMBL41518 ZINC13489623 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231104 Cn1cncc1C(OCc1ccc(nc1-c1ccc2ccccc2c1)C#N)c1ccc(cc1)C#N InChI=1S/C29H21N5O/c1-34-19-32-17-27(34)29(22-8-6-20(15-30)7-9-22)35-18-25-12-13-26(16-31)33-28(25)24-11-10-21-4-2-3-5-23(21)14-24/h2-14,17,19,29H,18H2,1H3 FHXPSLHVQVYMRI-UHFFFAOYSA-N 50127310 5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-naphthalen-2-yl-pyridine-2-carbonitrile::CHEMBL41515 Geranylgeranyl transferase type-1 subunit beta 5500 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127310&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286730 104019202 CHEMBL41515 ZINC13489627 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231113 Cn1cncc1C(OCc1ccc(C#N)c(n1)-c1cccc(Cl)c1)c1ccc(cc1)C#N InChI=1S/C25H18ClN5O/c1-31-16-29-14-23(31)25(18-7-5-17(12-27)6-8-18)32-15-22-10-9-20(13-28)24(30-22)19-3-2-4-21(26)11-19/h2-11,14,16,25H,15H2,1H3 QXYYIUKVUKRLDO-UHFFFAOYSA-N 50127333 2-(3-Chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-nicotinonitrile::CHEMBL288523 Geranylgeranyl transferase type-1 subunit beta 1100 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127333 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127333&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286723 104019225 CHEMBL288523 ZINC13489593 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231115 Cn1cncc1C(OCc1ccc(C#N)c(n1)-c1ccc2ccccc2c1)c1ccc(cc1)C#N InChI=1S/C29H21N5O/c1-34-19-32-17-27(34)29(22-8-6-20(15-30)7-9-22)35-18-26-13-12-25(16-31)28(33-26)24-11-10-21-4-2-3-5-23(21)14-24/h2-14,17,19,29H,18H2,1H3 SCMATKNFQYNVLH-UHFFFAOYSA-N 50127330 6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-2-naphthalen-2-yl-nicotinonitrile::CHEMBL38974 Geranylgeranyl transferase type-1 subunit beta 2600 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127330 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127330&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286304 104019222 CHEMBL38974 ZINC13489597 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231116 COc1cccc(c1)-c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N InChI=1S/C27H22N4O2/c1-31-18-30-16-26(31)27(21-9-6-19(14-28)7-10-21)33-17-23-11-8-20(15-29)12-25(23)22-4-3-5-24(13-22)32-2/h3-13,16,18,27H,17H2,1-2H3 QQZYKSKGVSDVOW-UHFFFAOYSA-N 13383 4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)methoxy]methyl}-3-(3-methoxyphenyl)benzonitrile::A313326 Analogue 19::CHEMBL43455 Geranylgeranyl transferase type-1 subunit beta 3900 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13383 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13383&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 10238214 46513790 CHEMBL43455 ZINC13489575 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231117 Cn1cncc1C(OCc1ccc(cc1-c1cccc(Cl)c1)C#N)c1ccc(nc1)C#N InChI=1S/C25H18ClN5O/c1-31-16-29-14-24(31)25(19-7-8-22(12-28)30-13-19)32-15-20-6-5-17(11-27)9-23(20)18-3-2-4-21(26)10-18/h2-10,13-14,16,25H,15H2,1H3 GTZYFRCYXBCPDJ-UHFFFAOYSA-N 50127323 5-[(3'-Chloro-5-cyano-biphenyl-2-ylmethoxy)-(3-methyl-3H-imidazol-4-yl)-methyl]-pyridine-2-carbonitrile::CHEMBL38616 Geranylgeranyl transferase type-1 subunit beta 8620.0 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127323 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127323&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286802 104019215 CHEMBL38616 ZINC13489577 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9 50231119 Cn1cncc1C(OCc1ccc(nc1N1CCOCC1)C#N)c1ccc(cc1)C#N InChI=1S/C23H22N6O2/c1-28-16-26-14-21(28)22(18-4-2-17(12-24)3-5-18)31-15-19-6-7-20(13-25)27-23(19)29-8-10-30-11-9-29/h2-7,14,16,22H,8-11,15H2,1H3 CPXJZBUXLKGBDP-UHFFFAOYSA-N 50127325 5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-morpholin-4-yl-pyridine-2-carbonitrile::CHEMBL290161 Geranylgeranyl transferase type-1 subunit beta >10 ChEMBL 10.1016/s0960-894x(03)00195-1 10.7270/Q27080TK 12699757 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50127325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000040&target=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50127325&enzyme=Geranylgeranyl+transferase+type-1+subunit+beta&column=ki&startPg=0&Increment=50&submit=Search 44286731 104019217 CHEMBL290161 ZINC13489625 1 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST Geranylgeranyl transferase type-1 subunit beta PGTB1_HUMAN P53609 Q5MJP9