BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 452934 NC(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-1-3-10(4-2-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+ BRZWHXQQGAAXPX-VZUCSPMQSA-N 259810 US9505766, 10 Serine/threonine-protein kinase Nek2 [T175A] 900 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259810&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938775 350084504 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452935 NC(=O)C(=C\c1ccc(cc1)-c1c[nH]c2ncccc12)\C#N InChI=1S/C17H12N4O/c18-9-13(16(19)22)8-11-3-5-12(6-4-11)15-10-21-17-14(15)2-1-7-20-17/h1-8,10H,(H2,19,22)(H,20,21)/b13-8+ AENKGHPUTMOKKU-MDWZMJQESA-N 259811 US9505766, 11 Serine/threonine-protein kinase Nek2 [T175A] 109 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259811&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 67206349 350084505 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452936 NC(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N InChI=1S/C18H12N4O2/c19-9-13(17(20)24)8-11-3-1-4-12(7-11)16(23)15-10-22-18-14(15)5-2-6-21-18/h1-8,10H,(H2,20,24)(H,21,22)/b13-8+ CEPQIZUYOXYNFQ-MDWZMJQESA-N 259812 US9505766, 12 Serine/threonine-protein kinase Nek2 [T175A] 3000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259812&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938387 350084506 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452937 NC(=O)C(=C\c1ccc2[nH]ncc2c1)\C#N InChI=1S/C11H8N4O/c12-5-8(11(13)16)3-7-1-2-10-9(4-7)6-14-15-10/h1-4,6H,(H2,13,16)(H,14,15)/b8-3+ JIMIDTDLZHFIJW-FPYGCLRLSA-N 259813 US9505766, 13 Serine/threonine-protein kinase Nek2 [T175A] 3000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259813&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938511 350084507 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452938 O=C(N1CCCC1)C(=C\c1ccc2[nH]ncc2c1)\C#N InChI=1S/C15H14N4O/c16-9-12(15(20)19-5-1-2-6-19)7-11-3-4-14-13(8-11)10-17-18-14/h3-4,7-8,10H,1-2,5-6H2,(H,17,18)/b12-7+ FJJMDXPMAYEZEB-KPKJPENVSA-N 259814 US9505766, 14 Serine/threonine-protein kinase Nek2 [T175A] >10000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259814 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259814&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 68347770 350084508 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452939 NC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N InChI=1S/C11H8N4O/c12-5-9(11(13)16)3-7-1-2-8-6-14-15-10(8)4-7/h1-4,6H,(H2,13,16)(H,14,15)/b9-3+ XLGYCNBBWHAJDG-YCRREMRBSA-N 259815 US9505766, 15 Serine/threonine-protein kinase Nek2 [T175A] 3000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259815&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938388 350084509 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452940 CC(C)NC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N InChI=1S/C14H14N4O/c1-9(2)17-14(19)12(7-15)5-10-3-4-11-8-16-18-13(11)6-10/h3-6,8-9H,1-2H3,(H,16,18)(H,17,19)/b12-5+ ZPHLHEVVHGCJDL-LFYBBSHMSA-N 259817 US9505766, 17 Serine/threonine-protein kinase Nek2 [T175A] >10000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259817&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 68347771 350084511 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452941 NC(=O)C(=C\C1CCN(CC1)c1ncnc2[nH]cnc12)\C#N InChI=1S/C14H15N7O/c15-6-10(12(16)22)5-9-1-3-21(4-2-9)14-11-13(18-7-17-11)19-8-20-14/h5,7-9H,1-4H2,(H2,16,22)(H,17,18,19,20)/b10-5+ UQVVQLRAEQBLIK-BJMVGYQFSA-N 259818 US9505766, 18 Serine/threonine-protein kinase Nek2 [T175A] 211 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259818&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 67205351 350084512 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452942 CS(=O)(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N InChI=1S/C15H11N5O2S/c1-23(21,22)12(7-16)6-10-2-4-11(5-3-10)13-14-15(19-8-17-13)20-9-18-14/h2-6,8-9H,1H3,(H,17,18,19,20)/b12-6+ NUTCBXHBYDJNKL-WUXMJOGZSA-N 259819 US9505766, 20 Serine/threonine-protein kinase Nek2 [T175A] 200 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259819&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938773 350084513 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452943 O=S(=O)(C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N)c1ccccc1 InChI=1S/C20H13N5O2S/c21-11-17(28(26,27)16-4-2-1-3-5-16)10-14-6-8-15(9-7-14)18-19-20(24-12-22-18)25-13-23-19/h1-10,12-13H,(H,22,23,24,25)/b17-10+ DZMXVPYWGQHCRO-LICLKQGHSA-N 259820 US9505766, 21 Serine/threonine-protein kinase Nek2 [T175A] 1000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259820 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259820&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938774 350084514 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452944 NC(=O)C(=C\c1ccc(cc1)-c1ccncc1)\C#N InChI=1S/C15H11N3O/c16-10-14(15(17)19)9-11-1-3-12(4-2-11)13-5-7-18-8-6-13/h1-9H,(H2,17,19)/b14-9+ FYPQUUUPVSAJTG-NTEUORMPSA-N 259821 US9505766, 22 Serine/threonine-protein kinase Nek2 [T175A] 8000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259821&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 68347790 350084515 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452945 NC(=O)C(=C\c1cccc(c1)-c1ncnc2[nH]cnc12)\C#N InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-2-1-3-10(4-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+ IFFOEIRCDOBKFH-VZUCSPMQSA-N 259822 US9505766, 23 Serine/threonine-protein kinase Nek2 [T175A] 1000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259822&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 68347773 350084516 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452946 O=C(N1CCCC1)C(=C\c1ccc2cn[nH]c2c1)\C#N InChI=1S/C15H14N4O/c16-9-13(15(20)19-5-1-2-6-19)7-11-3-4-12-10-17-18-14(12)8-11/h3-4,7-8,10H,1-2,5-6H2,(H,17,18)/b13-7+ YZHVOWFHVJPKPH-NTUHNPAUSA-N 259824 US9505766, 25 Serine/threonine-protein kinase Nek2 [T175A] 6500 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259824 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259824&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938891 350084518 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452947 CS(=O)(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N InChI=1S/C18H13N3O3S/c1-25(23,24)14(10-19)9-12-4-2-5-13(8-12)17(22)16-11-21-18-15(16)6-3-7-20-18/h2-9,11H,1H3,(H,20,21)/b14-9+ JVUYFKGAACUDSV-NTEUORMPSA-N 259825 US9505766, 29 Serine/threonine-protein kinase Nek2 [T175A] 1000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259825 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259825&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 71250196 350084519 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452948 N#C\C=C\c1ccc(cc1)-c1ccncc1 InChI=1S/C14H10N2/c15-9-1-2-12-3-5-13(6-4-12)14-7-10-16-11-8-14/h1-8,10-11H/b2-1+ PCFKTRCTTGIQLS-OWOJBTEDSA-N 259826 US9505766, 30 Serine/threonine-protein kinase Nek2 [T175A] >300000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259826&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 89403409 350084520 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452949 CCOP(=O)(OCC)C(=C\c1ccc(cc1)-c1ccncc1)\C#N InChI=1S/C18H19N2O3P/c1-3-22-24(21,23-4-2)18(14-19)13-15-5-7-16(8-6-15)17-9-11-20-12-10-17/h5-13H,3-4H2,1-2H3/b18-13+ FJKJKXLQLWSSGR-QGOAFFKASA-N 259827 US9505766, 31 Serine/threonine-protein kinase Nek2 [T175A] 40000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259827&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938894 350084521 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452950 NC(=O)C(=C\c1nc2c(N)ncnc2n1CCCO)\C#N InChI=1S/C12H13N7O2/c13-5-7(11(15)21)4-8-18-9-10(14)16-6-17-12(9)19(8)2-1-3-20/h4,6,20H,1-3H2,(H2,15,21)(H2,14,16,17)/b7-4+ YADAJQRYASQJMB-QPJJXVBHSA-N 259829 US9505766, 33 Serine/threonine-protein kinase Nek2 [T175A] 10000 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259829&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938896 350084523 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452951 CNC(=O)C(=C\C1CCN(CC1)c1ncnc2[nH]cnc12)\C#N InChI=1S/C15H17N7O/c1-17-15(23)11(7-16)6-10-2-4-22(5-3-10)14-12-13(19-8-18-12)20-9-21-14/h6,8-10H,2-5H2,1H3,(H,17,23)(H,18,19,20,21)/b11-6+ GVDKYWUWIBMHLJ-IZZDOVSWSA-N 259832 US9505766, 36 Serine/threonine-protein kinase Nek2 [T175A] 440 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259832&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 52938892 350084526 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452952 COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(N)=O)cc12 InChI=1S/C20H18N4O4/c1-26-16-8-12(9-17(27-2)19(16)28-3)18-14-7-11(4-5-15(14)23-24-18)6-13(10-21)20(22)25/h4-9H,1-3H3,(H2,22,25)(H,23,24)/b13-6+ IBUMAHMUIWPTCV-AWNIVKPZSA-N 259836 US9505766, 40 Serine/threonine-protein kinase Nek2 [T175A] 189 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259836&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 131954194 350084530 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452953 CNC(=O)C(=C\c1ccc2[nH]nc(-c3cc(OC)c(OC)c(OC)c3)c2c1)\C#N InChI=1S/C21H20N4O4/c1-23-21(26)14(11-22)7-12-5-6-16-15(8-12)19(25-24-16)13-9-17(27-2)20(29-4)18(10-13)28-3/h5-10H,1-4H3,(H,23,26)(H,24,25)/b14-7+ JGIBKTCCYJBOMS-VGOFMYFVSA-N 259837 US9505766, 41 Serine/threonine-protein kinase Nek2 [T175A] 1140 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259837&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 131954195 350084531 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9 452954 COc1cc(cc(OC)c1OC)-c1n[nH]c2ccc(\C=C(/C#N)C(=O)N(C)C)cc12 InChI=1S/C22H22N4O4/c1-26(2)22(27)15(12-23)8-13-6-7-17-16(9-13)20(25-24-17)14-10-18(28-3)21(30-5)19(11-14)29-4/h6-11H,1-5H3,(H,24,25)/b15-8+ VLDMPVNRZYIDHU-OVCLIPMQSA-N 259838 US9505766, 42 Serine/threonine-protein kinase Nek2 [T175A] 3800 7.6 25.00 C US Patent 10.7270/Q2639NPR aid1803662 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11172&target=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259838&enzyme=Serine%2Fthreonine-protein+kinase+Nek2+%5BT175A%5D&column=ki&startPg=0&Increment=50&submit=Search 131954196 350084532 1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKAFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGESKENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 2JAV,2W5B,2W5H,5M53,5M57,6TM5 Serine/threonine-protein kinase Nek2 NEK2_HUMAN P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9