BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 339378 N#C\C=C\c1ccc(cc1)-c1ccncc1 InChI=1S/C14H10N2/c15-9-1-2-12-3-5-13(6-4-12)14-7-10-16-11-8-14/h1-8,10-11H/b2-1+ PCFKTRCTTGIQLS-OWOJBTEDSA-N 259826 US9505766, 30 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >300000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259826&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 89403409 350084520 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452881 CC(=O)\C=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO InChI=1S/C20H22N4O2/c1-13-4-7-15(8-5-13)17-16(9-6-14(2)26)24(10-3-11-25)20-18(17)19(21)22-12-23-20/h4-9,12,25H,3,10-11H2,1-2H3,(H2,21,22,23)/b9-6+ JUIPXPYGIKPHFM-RMKNXTFCSA-N 259802 US9505766, Me enone (1) Ribosomal protein S6 kinase alpha-3 [399-740,C436V] 1700 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259802&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 57856455 350084496 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452882 COC(=O)\C=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO InChI=1S/C20H22N4O3/c1-13-4-6-14(7-5-13)17-15(8-9-16(26)27-2)24(10-3-11-25)20-18(17)19(21)22-12-23-20/h4-9,12,25H,3,10-11H2,1-2H3,(H2,21,22,23)/b9-8+ SUWNTOBZXIAHKB-CMDGGOBGSA-N 259804 US9505766, Me acrylate (2) Ribosomal protein S6 kinase alpha-3 [399-740,C436V] 190 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259804&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 16662748 350084498 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452883 Cc1ccc(cc1)-c1c(\C=C\C#N)n(CCCO)c2ncnc(N)c12 InChI=1S/C19H19N5O/c1-13-5-7-14(8-6-13)16-15(4-2-9-20)24(10-3-11-25)19-17(16)18(21)22-12-23-19/h2,4-8,12,25H,3,10-11H2,1H3,(H2,21,22,23)/b4-2+ LPADWFDQODOOMS-DUXPYHPUSA-N 259803 US9505766, acrylonitrile (3) Ribosomal protein S6 kinase alpha-3 [399-740,C436V] 1500 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259803&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 56840684 350084497 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452884 COC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N InChI=1S/C21H21N5O3/c1-13-4-6-14(7-5-13)17-16(10-15(11-22)21(28)29-2)26(8-3-9-27)20-18(17)19(23)24-12-25-20/h4-7,10,12,27H,3,8-9H2,1-2H3,(H2,23,24,25)/b15-10+ GDXHZXJALWQIPQ-XNTDXEJSSA-N 259805 US9505766, CN-OMe (4) Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >10000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259805 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259805&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938515 350084499 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452885 Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)OC(C)(C)C)n(CCCO)c2ncnc(N)c12 InChI=1S/C24H27N5O3/c1-15-6-8-16(9-7-15)19-18(12-17(13-25)23(31)32-24(2,3)4)29(10-5-11-30)22-20(19)21(26)27-14-28-22/h6-9,12,14,30H,5,10-11H2,1-4H3,(H2,26,27,28)/b17-12+ IEUOMYJAIZIKES-SFQUDFHCSA-N 259806 US9505766, CN-OtBu (5) Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >10000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259806&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938516 350084500 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452886 Cc1ccc(cc1)-c1c(\C=C(/C#N)C(N)=O)n(CCCO)c2ncnc(N)c12 InChI=1S/C20H20N6O2/c1-12-3-5-13(6-4-12)16-15(9-14(10-21)19(23)28)26(7-2-8-27)20-17(16)18(22)24-11-25-20/h3-6,9,11,27H,2,7-8H2,1H3,(H2,23,28)(H2,22,24,25)/b14-9+ SZAXHJXUPGRTIP-NTEUORMPSA-N 259807 US9505766, CN-NH2 (6) Ribosomal protein S6 kinase alpha-3 [399-740,C436V] 5000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259807&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938641 350084501 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452887 CC(C)NC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N InChI=1S/C23H26N6O2/c1-14(2)28-23(31)17(12-24)11-18-19(16-7-5-15(3)6-8-16)20-21(25)26-13-27-22(20)29(18)9-4-10-30/h5-8,11,13-14,30H,4,9-10H2,1-3H3,(H,28,31)(H2,25,26,27)/b17-11+ POTINGKLYOETSI-GZTJUZNOSA-N 259808 US9505766, 74::US9505766, CN-NHiPr (7) Ribosomal protein S6 kinase alpha-3 [399-740,C436V] 5500 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259808&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938644 350084502 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452923 NC(=O)C(=C\c1ccc(cc1)-c1ncnc2[nH]cnc12)\C#N InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-1-3-10(4-2-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+ BRZWHXQQGAAXPX-VZUCSPMQSA-N 259810 US9505766, 10 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] 100000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259810&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938775 350084504 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452924 NC(=O)C(=C\c1ccc(cc1)-c1c[nH]c2ncccc12)\C#N InChI=1S/C17H12N4O/c18-9-13(16(19)22)8-11-3-5-12(6-4-11)15-10-21-17-14(15)2-1-7-20-17/h1-8,10H,(H2,19,22)(H,20,21)/b13-8+ AENKGHPUTMOKKU-MDWZMJQESA-N 259811 US9505766, 11 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] 150000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259811 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259811&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 67206349 350084505 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452925 NC(=O)C(=C\c1cccc(c1)C(=O)c1c[nH]c2ncccc12)\C#N InChI=1S/C18H12N4O2/c19-9-13(17(20)24)8-11-3-1-4-12(7-11)16(23)15-10-22-18-14(15)5-2-6-21-18/h1-8,10H,(H2,20,24)(H,21,22)/b13-8+ CEPQIZUYOXYNFQ-MDWZMJQESA-N 259812 US9505766, 12 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] 40000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259812 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259812&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938387 350084506 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452926 NC(=O)C(=C\c1ccc2[nH]ncc2c1)\C#N InChI=1S/C11H8N4O/c12-5-8(11(13)16)3-7-1-2-10-9(4-7)6-14-15-10/h1-4,6H,(H2,13,16)(H,14,15)/b8-3+ JIMIDTDLZHFIJW-FPYGCLRLSA-N 259813 US9505766, 13 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >150000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259813&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938511 350084507 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452927 NC(=O)C(=C\c1ccc2cn[nH]c2c1)\C#N InChI=1S/C11H8N4O/c12-5-9(11(13)16)3-7-1-2-8-6-14-15-10(8)4-7/h1-4,6H,(H2,13,16)(H,14,15)/b9-3+ XLGYCNBBWHAJDG-YCRREMRBSA-N 259815 US9505766, 15 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >150000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259815 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259815&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938388 350084509 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452928 NC(=O)C(=C\c1ccc(cc1)-c1ccncc1)\C#N InChI=1S/C15H11N3O/c16-10-14(15(17)19)9-11-1-3-12(4-2-11)13-5-7-18-8-6-13/h1-9H,(H2,17,19)/b14-9+ FYPQUUUPVSAJTG-NTEUORMPSA-N 259821 US9505766, 22 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] 150000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259821&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 68347790 350084515 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452929 NC(=O)C(=C\c1cccc(c1)-c1ncnc2[nH]cnc12)\C#N InChI=1S/C15H10N6O/c16-6-11(14(17)22)5-9-2-1-3-10(4-9)12-13-15(20-7-18-12)21-8-19-13/h1-5,7-8H,(H2,17,22)(H,18,19,20,21)/b11-5+ IFFOEIRCDOBKFH-VZUCSPMQSA-N 259822 US9505766, 23 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >10000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259822 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259822&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 68347773 350084516 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452930 NC(=O)C(=C\c1ccc(cc1)-c1cn[nH]c1)\C#N InChI=1S/C13H10N4O/c14-6-11(13(15)18)5-9-1-3-10(4-2-9)12-7-16-17-8-12/h1-5,7-8H,(H2,15,18)(H,16,17)/b11-5+ BNRLLVUNYCBXNJ-VZUCSPMQSA-N 259823 US9505766, 24 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >150000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259823 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259823&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938890 350084517 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452931 CCOP(=O)(OCC)C(=C\c1ccc(cc1)-c1ccncc1)\C#N InChI=1S/C18H19N2O3P/c1-3-22-24(21,23-4-2)18(14-19)13-15-5-7-16(8-6-15)17-9-11-20-12-10-17/h5-13H,3-4H2,1-2H3/b18-13+ FJKJKXLQLWSSGR-QGOAFFKASA-N 259827 US9505766, 31 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >150000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259827&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938894 350084521 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452932 Cc1ccc(cc1)-c1c(\C=C(/C#N)c2ccccn2)n(CCCO)c2ncnc(N)c12 InChI=1S/C24H22N6O/c1-16-6-8-17(9-7-16)21-20(13-18(14-25)19-5-2-3-10-27-19)30(11-4-12-31)24-22(21)23(26)28-15-29-24/h2-3,5-10,13,15,31H,4,11-12H2,1H3,(H2,26,28,29)/b18-13+ PTVACVSGZJWNRY-QGOAFFKASA-N 259828 US9505766, 32 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >10000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259828&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 68347712 350084522 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7 452933 NC(=O)C(=C\c1nc2c(N)ncnc2n1CCCO)\C#N InChI=1S/C12H13N7O2/c13-5-7(11(15)21)4-8-18-9-10(14)16-6-17-12(9)19(8)2-1-3-20/h4,6,20H,1-3H2,(H2,15,21)(H2,14,16,17)/b7-4+ YADAJQRYASQJMB-QPJJXVBHSA-N 259829 US9505766, 33 Ribosomal protein S6 kinase alpha-3 [399-740,C436V] >150000 8 22.00 C US Patent 10.7270/Q2639NPR aid1803661 US9505766 Taunton, Jr., JW; Maglathlin, R; Serafimova, I; Cohen, MS; Miller, R; Paavilainen, V; McFarland, J; Krishnan, S The Regents of the University of California http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=259829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11171&target=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=259829&enzyme=Ribosomal+protein+S6+kinase+alpha-3+%5B399-740%2CC436V%5D&column=ki&startPg=0&Increment=50&submit=Search 52938896 350084523 1 MQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVVKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEPVGRSTLAQRRGIKKITSTAL Ribosomal protein S6 kinase alpha-3 KS6A3_HUMAN P51812 B2R9V4 Q4VAP3 Q59H26 Q5JPK8 Q7Z3Z7