BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 448936 ONC(=O)[C@]1(F)[C@@H]([C@H]1c1ccc(Br)cc1)c1ccccc1 InChI=1S/C16H13BrFNO2/c17-12-8-6-11(7-9-12)14-13(10-4-2-1-3-5-10)16(14,18)15(20)19-21/h1-9,13-14,21H,(H,19,20)/t13-,14-,16+/m1/s1 IWMDHRIUFCQJBC-FMKPAKJESA-N 257501 US9505736, (1S,2S,3S)-2-(4-Bromophenyl)-1- fluoro-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 60 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257501&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 72948225 347917303 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448937 ONC(=O)[C@@]1(F)[C@@H]([C@H]1c1cc(Cl)c2OCCOc2c1)c1ccccc1 InChI=1S/C18H15ClFNO4/c19-12-8-11(9-13-16(12)25-7-6-24-13)15-14(10-4-2-1-3-5-10)18(15,20)17(22)21-23/h1-5,8-9,14-15,23H,6-7H2,(H,21,22)/t14-,15-,18-/m1/s1 TZNSBMGNVJVYIP-IIDMSEBBSA-N 257502 US9505736, (1R,2S,3S)-2-(8-Chloro-2,3- dihydrobenzo[b][1,4]dioxin-6-yl)-1- fluoro-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 6470 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257502&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 72950519 347917304 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448938 Cc1cnc(nc1)-c1ccc(cc1)[C@@H]1[C@@H](c2ccccc2)[C@@]1(F)C(=O)NO InChI=1S/C21H18FN3O2/c1-13-11-23-19(24-12-13)16-9-7-15(8-10-16)18-17(14-5-3-2-4-6-14)21(18,22)20(26)25-27/h2-12,17-18,27H,1H3,(H,25,26)/t17-,18-,21+/m1/s1 LERFWXLGVNOQCJ-OPYAIIAOSA-N 257503 US9505736, (1S,2S,3S)-1-Fluoro-N-hydroxy-2-(4-(5- methylpyrimidin-2-yl)phenyl)-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 20 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257503&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 72950863 347917305 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448939 Cc1cnc(nc1)-c1ccc(cc1)[C@@H]1[C@@H](c2ccccc2)[C@@]1(Cl)C(=O)NO InChI=1S/C21H18ClN3O2/c1-13-11-23-19(24-12-13)16-9-7-15(8-10-16)18-17(14-5-3-2-4-6-14)21(18,22)20(26)25-27/h2-12,17-18,27H,1H3,(H,25,26)/t17-,18-,21+/m1/s1 ZOHXVMRBDNGIDM-OPYAIIAOSA-N 50155803 CHEMBL3793455::US9505736, (1S,2S,3S)-1-Chloro-N-hydroxy-2-(4-(5- methylpyrimidin-2-yl)phenyl)-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 110 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50155803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50155803&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 72948226 104043170 CHEMBL3793455 ZINC36748718 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448940 Cc1cnc(nc1)-c1ccc(cc1)[C@H]1[C@H](c2ccccc2)[C@]1(Cl)C(=O)NO InChI=1S/C21H18ClN3O2/c1-13-11-23-19(24-12-13)16-9-7-15(8-10-16)18-17(14-5-3-2-4-6-14)21(18,22)20(26)25-27/h2-12,17-18,27H,1H3,(H,25,26)/t17-,18-,21+/m0/s1 ZOHXVMRBDNGIDM-BBTUJRGHSA-N 257504 US9505736, (1R,2R,3R)-1-Chloro-N-hydroxy-2-(4-(5- methylpyrimidin-2-yl)phenyl)-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 1580 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257504&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 118237240 347917306 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448941 Cc1cnc(nc1)-c1ccc(cc1)[C@H]1[C@H](c2ccccc2)[C@]1(F)C(=O)NO InChI=1S/C21H18FN3O2/c1-13-11-23-19(24-12-13)16-9-7-15(8-10-16)18-17(14-5-3-2-4-6-14)21(18,22)20(26)25-27/h2-12,17-18,27H,1H3,(H,25,26)/t17-,18-,21+/m0/s1 LERFWXLGVNOQCJ-BBTUJRGHSA-N 257505 US9505736, (1R,2R,3R)-1-Fluoro-N-hydroxy-2-(4-(5- methylpyrimidin-2-yl)phenyl)-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 1430 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257505&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 118237259 347917307 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448942 ONC(=O)[C@]1(F)[C@@H]([C@H]1c1ccc(cc1)-c1ncc(OC(F)F)cn1)c1ccccc1 InChI=1S/C21H16F3N3O3/c22-20(23)30-15-10-25-18(26-11-15)14-8-6-13(7-9-14)17-16(12-4-2-1-3-5-12)21(17,24)19(28)27-29/h1-11,16-17,20,29H,(H,27,28)/t16-,17-,21+/m1/s1 RUTGGTYDBCHEPE-LZJOCLMNSA-N 50160874 CHEMBL3794485::US9505736, (1S,2S,3S)-2-(4-(5- (Difluoromethoxy)pyrimidin-2-yl)phenyl)-1- fluoro-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 40 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50160874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50160874&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 72948227 340134788 CHEMBL3794485 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448943 ONC(=O)[C@@]1(F)[C@H]([C@@H]1c1ccc(cc1)-c1ncc(OC(F)F)cn1)c1ccccc1 InChI=1S/C21H16F3N3O3/c22-20(23)30-15-10-25-18(26-11-15)14-8-6-13(7-9-14)17-16(12-4-2-1-3-5-12)21(17,24)19(28)27-29/h1-11,16-17,20,29H,(H,27,28)/t16-,17-,21+/m0/s1 RUTGGTYDBCHEPE-XGHQBKJUSA-N 257506 US9505736, (1R,2R,3R)-2-(4-(5- (Difluoromethoxy)pyrimidin-2-yl)phenyl)-1- fluoro-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 26000 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257506&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 90071087 347917308 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448944 ONC(=O)[C@@]1(F)[C@@H]([C@H]1c1ccc(cc1)-c1cnc(o1)C1CC1)c1ccccc1 InChI=1S/C22H19FN2O3/c23-22(21(26)25-27)18(14-4-2-1-3-5-14)19(22)15-8-6-13(7-9-15)17-12-24-20(28-17)16-10-11-16/h1-9,12,16,18-19,27H,10-11H2,(H,25,26)/t18-,19-,22-/m1/s1 FZFWDBNDYFWRRQ-WOIUINJBSA-N 257507 US9505736, (1R,2S,3S)-2-(4-(2-Cyclopropyloxazol- 5-yl)phenyl)-1-fluoro-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 4650 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257507&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 90071079 347917309 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448945 ONC(=O)[C@]1(F)[C@@H]([C@H]1c1ccc(cc1)-c1cnc(o1)C1CC1)c1ccccc1 InChI=1S/C22H19FN2O3/c23-22(21(26)25-27)18(14-4-2-1-3-5-14)19(22)15-8-6-13(7-9-15)17-12-24-20(28-17)16-10-11-16/h1-9,12,16,18-19,27H,10-11H2,(H,25,26)/t18-,19-,22+/m1/s1 FZFWDBNDYFWRRQ-KNKQGSTJSA-N 257508 US9505736, (1S,2S,3S)-2-(4-(2-Cyclopropyloxazol- 5-yl)phenyl)-1-fluoro-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 20 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257508&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 72948222 347917310 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448946 ONC(=O)[C@@]1(F)[C@@H]([C@H]1c1ccccc1)c1cnc(s1)-c1ccc(F)cc1 InChI=1S/C19H14F2N2O2S/c20-13-8-6-12(7-9-13)17-22-10-14(26-17)16-15(11-4-2-1-3-5-11)19(16,21)18(24)23-25/h1-10,15-16,25H,(H,23,24)/t15-,16-,19+/m1/s1 QZEPBMKPUBUIIG-MDZRGWNJSA-N 257509 US9505736, (1S,2R,3S)-1-Fluoro-2-(2-(4- fluorophenyl)thiazol-5-yl)-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 60 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257509&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 72950691 347917311 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448947 ONC(=O)[C@]1(F)[C@@H]([C@H]1c1ccc(cc1)-c1nccc(n1)C(F)(F)F)c1ccccc1 InChI=1S/C21H15F4N3O2/c22-20(19(29)28-30)16(12-4-2-1-3-5-12)17(20)13-6-8-14(9-7-13)18-26-11-10-15(27-18)21(23,24)25/h1-11,16-17,30H,(H,28,29)/t16-,17-,20+/m1/s1 DDTXYXHMSVMLET-HLIPFELVSA-N 50161831 CHEMBL3793932::US9505736, (1S,2S,3S)-1-Fluoro-N-hydroxy-2-phenyl- 3-(4-(4-(trifluoromethyl)pyrimidin-2- yl)phenyl)cyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 40 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50161831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50161831&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 72948224 341096906 CHEMBL3793932 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448948 ONC(=O)[C@@]1(F)[C@H]([C@@H]1c1ccc(cc1)-c1nccc(n1)C(F)(F)F)c1ccccc1 InChI=1S/C21H15F4N3O2/c22-20(19(29)28-30)16(12-4-2-1-3-5-12)17(20)13-6-8-14(9-7-13)18-26-11-10-15(27-18)21(23,24)25/h1-11,16-17,30H,(H,28,29)/t16-,17-,20+/m0/s1 DDTXYXHMSVMLET-ABSDTBQOSA-N 257510 US9505736, (1R,2R,3R)-1-Fluoro-N-hydroxy-2-phenyl- 3-(4-(4-(trifluoromethyl)pyrimidin-2- yl)phenyl)cyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 6870 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257510&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 90071088 347917312 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448949 ONC(=O)[C@]1(F)[C@@H]([C@H]1c1ccc(cc1)-c1ncc(F)cn1)c1ccccc1 InChI=1S/C20H15F2N3O2/c21-15-10-23-18(24-11-15)14-8-6-13(7-9-14)17-16(12-4-2-1-3-5-12)20(17,22)19(26)25-27/h1-11,16-17,27H,(H,25,26)/t16-,17-,20+/m1/s1 MREATSZIGJDNKB-HLIPFELVSA-N 50160879 CHEMBL3793392::US9505736, (1S,2S,3S)-1-Fluoro-2-(4-(5- fluoropyrimidin-2-yl)phenyl)-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 10 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50160879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50160879&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search OTF 5A2S 72722126 340134793 CHEMBL3793392 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448950 ONC(=O)[C@@]1(F)[C@H]([C@@H]1c1ccc(cc1)-c1ncc(F)cn1)c1ccccc1 InChI=1S/C20H15F2N3O2/c21-15-10-23-18(24-11-15)14-8-6-13(7-9-14)17-16(12-4-2-1-3-5-12)20(17,22)19(26)25-27/h1-11,16-17,27H,(H,25,26)/t16-,17-,20+/m0/s1 MREATSZIGJDNKB-ABSDTBQOSA-N 257511 US9505736, (1R,2R,3R)-1-Fluoro-2-(4-(5- fluoropyrimidin-2-yl)phenyl)-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] 410 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257511&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 90071089 347917313 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6 448951 ONC(=O)[C@@]1(F)[C@@H]([C@H]1c1ccnc(c1)C1CC1)c1ccccc1 InChI=1S/C18H17FN2O2/c19-18(17(22)21-23)15(12-4-2-1-3-5-12)16(18)13-8-9-20-14(10-13)11-6-7-11/h1-5,8-11,15-16,23H,6-7H2,(H,21,22)/t15-,16-,18-/m1/s1 SXPWNRUUCBNTEG-JFIYKMOQSA-N 257512 US9505736, (1R,2S,3S)-2-(2-Cyclopropylpyridin-4- yl)-1-fluoro-N-hydroxy-3- phenylcyclopropanecarboxamide Histone deacetylase 4 [648-729,745-1057] >50000 8 25.00 C US Patent 10.7270/Q2T152KR aid1803619 US9505736 Dominguez, C; Breccia, P; Luckhurst, CA; Burli, RW; Stott, AJ CHDI Foundation Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=257512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=11101&target=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=257512&enzyme=Histone+deacetylase+4+%5B648-729%2C745-1057%5D&column=ki&startPg=0&Increment=50&submit=Search 72950350 347917314 1 TKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNGSGSDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT 2VQQ Histone deacetylase 4 HDAC4_HUMAN P56524 E9PGB9 F5GX36 Q86YH7 Q9UND6