BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 417433 Nc1ccc(cc1Cl)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C8H8ClN5O4S3/c9-5-3-4(1-2-6(5)10)21(17,18)14-7-12-13-8(19-7)20(11,15)16/h1-3H,10H2,(H,12,14)(H2,11,15,16) CYGCWJCVIJAEOL-UHFFFAOYSA-N 11622 β-CA inhibitor, 1::2-N-(4-amino-3-chlorobenzene)-1,3,4-thiadiazole-2,5-disulfonamide::5-(4-Amino-3-chlorobenzenesulfonamido)-1,3,4-thiadiazole-2-sulfonamide::aminobenzolamide 17c Carbonic anhydrase 2 4.5e+2 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11622&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 10959593 46512145 ZINC13520184 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417434 Nc1c(F)cc(cc1Br)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C8H7BrFN5O4S3/c9-4-1-3(2-5(10)6(4)11)22(18,19)15-7-13-14-8(20-7)21(12,16)17/h1-2H,11H2,(H,13,15)(H2,12,16,17) KHBWKBINDOFBGN-UHFFFAOYSA-N 11626 β-CA inhibitor, 2::2-N-(4-amino-3-bromo-5-fluorobenzene)-1,3,4-thiadiazole-2,5-disulfonamide::5-{[(4-amino-3-bromo-5-fluorophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide::aminobenzolamide 19 Carbonic anhydrase 2 4.3e+2 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11626&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 11026415 46512149 ZINC13520201 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417435 Nc1c(F)cc(cc1I)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C8H7FIN5O4S3/c9-4-1-3(2-5(10)6(4)11)22(18,19)15-7-13-14-8(20-7)21(12,16)17/h1-2H,11H2,(H,13,15)(H2,12,16,17) YMECUEKBIBTNRW-UHFFFAOYSA-N 11627 β-CA inhibitor, 3::2-N-(4-amino-3-fluoro-5-iodobenzene)-1,3,4-thiadiazole-2,5-disulfonamide::5-{[(4-amino-3-fluoro-5-iodophenyl)sulfonyl]amino}-1,3,4-thiadiazole-2-sulfonamide::aminobenzolamide 20 Carbonic anhydrase 2 4.1e+2 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11627&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 10983658 46512150 ZINC13520205 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417436 Nc1c(F)cc(cc1Cl)S(N)(=O)=O InChI=1S/C6H6ClFN2O2S/c7-4-1-3(13(10,11)12)2-5(8)6(4)9/h1-2H,9H2,(H2,10,11,12) XFMRTCFRRBAJHW-UHFFFAOYSA-N 11605 β-CA inhibitor, 4::4-Amino-5-chloro-3-fluorobenzenesulfonamide::4-amino-3-chloro-5-fluorobenzene-1-sulfonamide::halogenosulfanilamide deriv. 6 Carbonic anhydrase 2 4.56e+3 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11605&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 10878827 46512130 ZINC13520141 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417437 Nc1c(F)cc(cc1Br)S(N)(=O)=O InChI=1S/C6H6BrFN2O2S/c7-4-1-3(13(10,11)12)2-5(8)6(4)9/h1-2H,9H2,(H2,10,11,12) GKYQTYGVQVABPW-UHFFFAOYSA-N 11606 β-CA inhibitor, 5::4-Amino-5-bromo-3-fluorobenzenesulfonamide::4-amino-3-bromo-5-fluorobenzene-1-sulfonamide::halogenosulfanilamide deriv. 7 Carbonic anhydrase 2 4.31e+3 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11606&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 10869299 46512131 ZINC13520143 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417438 Nc1c(F)cc(cc1I)S(N)(=O)=O InChI=1S/C6H6FIN2O2S/c7-4-1-3(13(10,11)12)2-5(8)6(4)9/h1-2H,9H2,(H2,10,11,12) KDXNVSMWRXCNMY-UHFFFAOYSA-N 11607 β-CA inhibitor, 6::4-Amino-3-fluoro-5-iodobenzenesulfonamide::4-amino-3-fluoro-5-iodobenzene-1-sulfonamide::CHEMBL69813::halogenosulfanilamide deriv. 8 Carbonic anhydrase 2 4.49e+3 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11607 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11607&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 10903168 46512132 CHEMBL69813 ZINC13520146 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417439 Nc1c(Cl)cc(cc1Cl)S(N)(=O)=O InChI=1S/C6H6Cl2N2O2S/c7-4-1-3(13(10,11)12)2-5(8)6(4)9/h1-2H,9H2,(H2,10,11,12) DVZMRTJKNJKEGV-UHFFFAOYSA-N 11608 β-CA inhibitor, 7::4-Amino-3,5-dichlorobenzenesulfonamide::4-amino-3,5-dichlorobenzene-1-sulfonamide::halogenosulfanilamide deriv. 9 Carbonic anhydrase 2 4.14e+3 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11608&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search SDA 1ZGE 89607 46512133 ZINC01255236 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417440 Nc1c(Cl)cc(cc1Br)S(N)(=O)=O InChI=1S/C6H6BrClN2O2S/c7-4-1-3(13(10,11)12)2-5(8)6(4)9/h1-2H,9H2,(H2,10,11,12) YJUGISJKPREUNY-UHFFFAOYSA-N 11609 β-CA inhibitor, 8::4-Amino-5-bromo-3-chlorobenzenesulfonamide::4-amino-3-bromo-5-chlorobenzene-1-sulfonamide::halogenosulfanilamide deriv. 10 Carbonic anhydrase 2 4.62e+3 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11609&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 11011569 46512134 ZINC13520149 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417441 Nc1c(Cl)cc(cc1I)S(N)(=O)=O InChI=1S/C6H6ClIN2O2S/c7-4-1-3(13(10,11)12)2-5(8)6(4)9/h1-2H,9H2,(H2,10,11,12) XMYFNJCFYZLWBO-UHFFFAOYSA-N 11610 β-CA inhibitor, 9::4-Amino-3-chloro-5-iodobenzenesulfonamide::4-amino-3-chloro-5-iodobenzene-1-sulfonamide::halogenosulfanilamide deriv. 11 Carbonic anhydrase 2 4.74e+3 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11610&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 11823783 46512135 ZINC13520152 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417442 Nc1c(Br)cc(cc1Br)S(N)(=O)=O InChI=1S/C6H6Br2N2O2S/c7-4-1-3(13(10,11)12)2-5(8)6(4)9/h1-2H,9H2,(H2,10,11,12) DLXJPWSYRLLYSV-UHFFFAOYSA-N 11611 β-CA inhibitor, 10::4-Amino-3,5-dibromobenzenesulfonamide::4-amino-3,5-dibromobenzene-1-sulfonamide::CHEMBL306195::halogenosulfanilamide deriv. 12 Carbonic anhydrase 2 4.52e+3 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11611&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3084733 46512136 CHEMBL306195 ZINC02146706 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417443 NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1 InChI=1S/C8H8N4O4S3/c9-18(13,14)8-11-10-7(17-8)12-19(15,16)6-4-2-1-3-5-6/h1-5H,(H,10,12)(H2,9,13,14) PWDGTQXZLNDOKS-UHFFFAOYSA-N 10886 2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide::BZA1::Benzolamide::Benzolamide (BZA)::CHEMBL73962 Carbonic anhydrase 2 4.6e+2 8.3 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.645539 10.7270/Q28C9V4F 22214209 aid1803214 Maresca, A; Scozzafava, A; Vullo, D; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10886&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3DB 3D8W,3DBU 18794 46511456 CHEMBL73962 DB07050 6920 ZINC04194731 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417588 OC(=O)c1ccc(Br)cc1 InChI=1S/C7H5BrO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10) TUXYZHVUPGXXQG-UHFFFAOYSA-N 239163 4-Bromobenzoic acid (1) Carbonic anhydrase 2 2.66e+3 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239163&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search Z82 3T6I,3LBW,3Q3M 11464 340132451 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417589 OC(=O)c1ccc(I)cc1 InChI=1S/C7H5IO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10) GHICCUXQJBDNRN-UHFFFAOYSA-N 50405325 4-Iodobenzoic acid (2)::CHEMBL101265 Carbonic anhydrase 2 2.14e+3 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405325 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405325&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search KZ6 7TZM 12085 163354349 CHEMBL101265 ZINC00167246 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417590 OC(=O)c1ccc(cc1)C#N InChI=1S/C8H5NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,(H,10,11) ADCUEPOHPCPMCE-UHFFFAOYSA-N 239164 4-Cyanobenzoic acid (3) Carbonic anhydrase 2 2.12e+3 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239164&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 12087 340132452 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417591 CC(=O)Nc1ccc(cc1)C(O)=O InChI=1S/C9H9NO3/c1-6(11)10-8-4-2-7(3-5-8)9(12)13/h2-5H,1H3,(H,10,11)(H,12,13) QCXJEYYXVJIFCE-UHFFFAOYSA-N 239165 4-Acetamidobenzoic acid (4) Carbonic anhydrase 2 3.67e+3 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=239165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=239165&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search TYZ 5RSO,2BNI,1W5K,1W5J,5PBD,3W93,3W92,5CUG,3W8V 19266 340132453 DB04500 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417592 OC(=O)c1ccc(cc1)[N+]([O-])=O InChI=1S/C7H5NO4/c9-7(10)5-1-3-6(4-2-5)8(11)12/h1-4H,(H,9,10) OTLNPYWUJOZPPA-UHFFFAOYSA-N 50405310 4-Nitrobenzoic acid (5)::CHEMBL101263 Carbonic anhydrase 2 8.10e+3 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50405310 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50405310&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 4NB 5N3J,3CHT,5J8G,7PGB 6108 163354334 262350 CHEMBL101263 C18625 ZINC01688307 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417593 OC(=O)C1CCCNC1 InChI=1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9) XJLSEXAGTJCILF-UHFFFAOYSA-N 50003624 (RS)-nipecotic acid::CHEMBL277498::Nipecotic::Piperidine-3-carboxylic acid::Piperidine-3-carboxylic acid (6)::Piperidine-3-carboxylic acid(nipecotic acid) Carbonic anhydrase 2 5.27e+3 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50003624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50003624&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search ID7 7Y7Y 4498 103917587 116931 CHEMBL277498 4564 ZINC03861497 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417594 OC(=O)\C=C\c1ccccc1O InChI=1S/C9H8O3/c10-8-4-2-1-3-7(8)5-6-9(11)12/h1-6,10H,(H,11,12)/b6-5+ PMOWTIHVNWZYFI-AATRIKPKSA-N 50146462 (2E)-3-(2-hydroxyphenyl)-2-propenoic acid::(2E)-3-(2-hydroxyphenyl)prop-2-enoic acid::(2E)-3-(2-hydroxyphenyl)prop-2-enoic acid (7)::(E)-2-hydroxycinnamic acid::(E)-3-(2-hydroxyphenyl)-2-propenoic acid::(E)-o-hydroxycinnamic acid::CHEMBL52564::o-Hydroxycinnamic acid (o-HCA)::o-hydroxy-trans-cinnamic acid::trans-2-coumaric acid::trans-o-hydroxycinnamic acid Carbonic anhydrase 2 4.17e+3 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50146462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50146462&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2HC 1V5Z,5BNL 637540 104035051 18176 CHEMBL52564 DB01650 C01772 ZINC00895911 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417595 OC(=O)\C=C\c1ccc(O)cc1 InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+ NGSWKAQJJWESNS-ZZXKWVIFSA-N 4374 (2E)-3-(4-hydroxyphenyl)prop-2-enoic acid::(2E)-3-(4-hydroxyphenyl)prop-2-enoic acid (8)::CHEMBL66879::p-Coumaric Acid::p-Hydroxycinnamic acid (p-HCA)::p-hydroxycinnamic acid::p-hydroxycinnamic acid (M4) Carbonic anhydrase 2 1.56e+3 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4374 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4374&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search HC4 3PHY,5J0A,2O7B,2O7F,2J3J,1GSX,1GSW,1GSV,4I3J,5MOV,3UME,3UMD,6UN2,3VE4,3VE3,1TS6,1TS7,1TS0,1TS8,1F98,1F9I,2QJ5,2QJ7,1OTD,1OTE,1OTB,8DZX,8DZY,8DZU,5GX9,1T18,1T19,1T1A,1T1B,1T1C,4F8J,1S4R,1S4S,2PYP,6MMD,4EYO,2I9V,3UBA,6UMY,6VZK,5VFM,5Y8T,1XFQ,1XFN,1NWZ,4I3A,2PHY,2KX6,8E1L,4WL9,1OTI,3A5R,3PYP,1S1Z,1S1Y,1OTA,1OT6,1OT9,2D01,4QEM,4HY8,1UWN,1D7E,8E03,8E02,8E09,1ODV,1UWP,6MKT,4BBT,4BBU,4BBV,1UGU,4RGR,6TC2,7NR2,8E1K,2D02,7SJJ,2PYR,4WLA,4B9O,2QWS,7NSW,7SPV,7SPW,7SPX,4I38,4I39,4I3I,1MZU,4ALB,2ZOI,2ZOH,5X13 637542 8034050 36090 CHEMBL66879 DB04066 5787 C00811 ZINC00039811 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417596 OC(=O)\C=C\c1ccc(O)c(O)c1 InChI=1S/C9H8O4/c10-7-3-1-6(5-8(7)11)2-4-9(12)13/h1-5,10-11H,(H,12,13)/b4-2+ QAIPRVGONGVQAS-DUXPYHPUSA-N 4375 (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid::(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid (9)::3,4-Dihydroxycinnamate, XVII::CHEMBL145::Caffeic acid::Caffeic acid, 1::cid_689043 Carbonic anhydrase 2 5.9e+2 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4375 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4375&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search DHC 3HOF,2O7D,4FB4,1KOU,6YRI,4YU7,6AWU,4EYQ,5VFJ,6I72,7NRR,3S2Z,4N0S 689043 8034051 16433 CHEMBL145 DB01880 5155 C01197 ZINC00058172 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417597 COc1cc(\C=C\C(O)=O)ccc1O InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+ KSEBMYQBYZTDHS-HWKANZROSA-N 50214744 (2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid::(2E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid (10)::CHEMBL32749::Ferulic acid (M5)::ferulic acid Carbonic anhydrase 2 3.50e+3 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50214744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50214744&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search FER 3NX2,1GKL,4PME,6G21,7ATJ,3PFC,2BNJ,1JT2,6YUX,1GW2,1GWT,6ATJ,7Z2U,1KYZ,7NTD,1UWC,3CBG,2BJH,5CXX,4RGU,4JB0,2WTN,6HOV,6HOQ,6HOP,6MBY,5X14 445858 104089679 17620 CHEMBL32749 DB07767 C01494 ZINC00058258 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 417598 Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) FDDDEECHVMSUSB-UHFFFAOYSA-N 10857 4-aminobenzene-1-sulfonamide::CHEMBL21::Sulfanilamide::aromatic sulfonamide compound 5::aromatic/heteroaromatic sulfonamide 2::halogenosulfanilamide deriv. 5a Carbonic anhydrase 2 2.96e+4 7.5 25.00 C Curated from the literature by BindingDB 10.3109/14756366.2011.650168 10.7270/Q2RF5SZW 22299588 aid1803218 Maresca, A; Vullo, D; Scozzafava, A; Manole, G; Supuran, CT Università degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10857&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search SAN 8BCB,1AJ0,4F93,4F92,4COQ,6RL9 5333 46511429 45373 CHEMBL21 DB00259 C07458 ZINC00002101 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903597 Nc1ccccc1S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) YAZSBRQTAHVVGE-UHFFFAOYSA-N 10855 2-aminobenzene-1-sulfonamide::CHEMBL6705::US10172837, 2-aminobenzenesulfonamide::aromatic/heteroaromatic sulfonamide 1::orthanilamide 17 Carbonic anhydrase 2 33700 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10855&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 72894 46511428 CHEMBL6705 ZINC00163348 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903598 Nc1ccc(cc1)S(N)(=O)=O InChI=1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10) FDDDEECHVMSUSB-UHFFFAOYSA-N 10857 4-aminobenzene-1-sulfonamide::CHEMBL21::Sulfanilamide::aromatic sulfonamide compound 5::aromatic/heteroaromatic sulfonamide 2::halogenosulfanilamide deriv. 5a Carbonic anhydrase 2 29600 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10857&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search SAN 8BCB,1AJ0,4F93,4F92,4COQ,6RL9 5333 46511429 45373 CHEMBL21 DB00259 C07458 ZINC00002101 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903599 NS(=O)(=O)c1ccc(CCC(O)=O)cc1 InChI=1S/C9H11NO4S/c10-15(13,14)8-4-1-7(2-5-8)3-6-9(11)12/h1-2,4-5H,3,6H2,(H,11,12)(H2,10,13,14) JUEONDBIBADVGD-UHFFFAOYSA-N 29277 CHEMBL451332::sulfonamide, 3 Carbonic anhydrase 2 28400 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29277 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29277&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search M28 2NN1,2NNO 3161908 81054706 CHEMBL451332 DB08156 ZINC04362893 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903600 Cc1ccc(cc1)S(N)(=O)=O InChI=1S/C7H9NO2S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H2,8,9,10) LMYRWZFENFIFIT-UHFFFAOYSA-N 10859 4-methylbenzene-1-sulfonamide::CHEMBL574::aromatic/heteroaromatic sulfonamide 4::hCA inhibitor, 7 Carbonic anhydrase 2 38900 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10859&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 4J8 4YXI,6GM9,5RTL,7OYP 6269 46511431 51094 CHEMBL574 C14412 ZINC00388056 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903601 NCc1ccc(cc1)S(N)(=O)=O InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11) TYMRLRRVMHJFTF-UHFFFAOYSA-N 10860 4-(aminomethyl)benzene-1-sulfonamide::CHEMBL419::MAFENIDE::aromatic sulfonamide compound 6::aromatic/heteroaromatic sulfonamide 5::hCA inhibitor, 9 Carbonic anhydrase 2 30700 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10860&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 6LH 5JNC 3998 46511432 CHEMBL419 DB06795 C07106 ZINC00001644 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903602 NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C8H12N2O2S/c9-6-5-7-1-3-8(4-2-7)13(10,11)12/h1-4H,5-6,9H2,(H2,10,11,12) FXNSVEQMUYPYJS-UHFFFAOYSA-N 10861 4-(2-aminoethyl)benzene-1-sulfonamide::CHEMBL7087::aromatic sulfonamide compound 7::aromatic/heteroaromatic sulfonamide 6 Carbonic anhydrase 2 29100 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10861&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search ZYX 2NNG 169682 46511433 CHEMBL7087 DB08782 ZINC00056629 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903603 Nc1ccc(cc1F)S(N)(=O)=O InChI=1S/C6H7FN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) HVFBADWBKHAPKV-UHFFFAOYSA-N 10862 4-Amino-3-fluorobenzenesulfonamide::4-amino-3-fluorobenzene-1-sulfonamide::CHEMBL6853::aromatic/heteroaromatic sulfonamide 7::halogenosulfanilamide deriv. 5b Carbonic anhydrase 2 28900 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10862&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 4687472 46511434 CHEMBL6853 ZINC06925827 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903604 Nc1ccc(cc1Cl)S(N)(=O)=O InChI=1S/C6H7ClN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) LFIOFZKZCDMGFG-UHFFFAOYSA-N 10863 4-Amino-3-chlorobenzenesulfonamide::4-amino-3-chlorobenzene-1-sulfonamide::CHEMBL7092::aromatic/heteroaromatic sulfonamide 8::halogenosulfanilamide deriv. 5c Carbonic anhydrase 2 27700 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10863&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1502014 46511435 CHEMBL7092 ZINC01420707 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903605 Nc1ccc(cc1Br)S(N)(=O)=O InChI=1S/C6H7BrN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) KQEVQYJWCZRLTJ-UHFFFAOYSA-N 10864 4-Amino-3-bromobenzenesulfonamide::4-amino-3-bromobenzene-1-sulfonamide::CHEMBL6724::aromatic/heteroaromatic sulfonamide 9::halogenosulfanilamide deriv. 5d Carbonic anhydrase 2 31600 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10864&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3526523 46511436 CHEMBL6724 ZINC12522340 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903606 Nc1ccc(cc1I)S(N)(=O)=O InChI=1S/C6H7IN2O2S/c7-5-3-4(12(9,10)11)1-2-6(5)8/h1-3H,8H2,(H2,9,10,11) HCODCRHNVCTCTR-UHFFFAOYSA-N 10865 4-Amino-3-iodobenzenesulfonamide::4-amino-3-iodobenzene-1-sulfonamide::CHEMBL268177::aromatic/heteroaromatic sulfonamide 10::halogenosulfanilamide deriv. 5e Carbonic anhydrase 2 32400 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10865&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 9861037 46511437 CHEMBL268177 ZINC13442499 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903607 Nc1cc(c(cc1S(N)(=O)=O)S(N)(=O)=O)C(F)(F)F InChI=1S/C7H8F3N3O4S2/c8-7(9,10)3-1-4(11)6(19(13,16)17)2-5(3)18(12,14)15/h1-2H,11H2,(H2,12,14,15)(H2,13,16,17) KRVABEGPNKGLOT-UHFFFAOYSA-N 10866 4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide::CHEMBL418::aromatic/heteroaromatic sulfonamide 11 Carbonic anhydrase 2 29600 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10866&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search I7C 2POW 69561 46511438 CHEMBL418 ZINC01676919 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903608 Nc1cc(Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O InChI=1S/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14) IHJCXVZDYSXXFT-UHFFFAOYSA-N 10867 4-amino-6-chlorobenzene-1,3-disulfonamide::CHEMBL266240::aromatic/heteroaromatic sulfonamide 12 Carbonic anhydrase 2 32500 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10867&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search I7B 7NML,2POV,3L14 67136 46511439 CHEMBL266240 C07460 ZINC01530783 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903609 Nc1nnc(s1)S(N)(=O)=O InChI=1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8) VGMVBPQOACUDRU-UHFFFAOYSA-N 10868 1,3,4-Thiadiazole-2-sulfonamide, 6::1,3,4-thiadiazole-2-sulfonamide 15::5-Amino-1,3,4-thiadiazole-2-sulphonamide (1)::5-amino-1,3,4-thiadiazole-2-sulfonamide::CHEMBL265674::aromatic/heteroaromatic sulfonamide 13 Carbonic anhydrase 2 2090 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10868&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1SA 2HNC,5TUO 84724 46509349 CHEMBL265674 ZINC16969869 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903610 Cn1nc(sc1=N)S(N)(=O)=O InChI=1S/C3H6N4O2S2/c1-7-2(4)10-3(6-7)11(5,8)9/h4H,1H3,(H2,5,8,9) BWSMJWLWXNCHHP-UHFFFAOYSA-N 10869 5-imino-4-methyl-4,5-dihydro-1,3,4-thiadiazole-2-sulfonamide::CHEMBL6753::aromatic/heteroaromatic sulfonamide 14 Carbonic anhydrase 2 2380 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10869&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 5172475 46511440 CHEMBL6753 ZINC05423825 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903611 Nc1ccc(cc1)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C8H9N5O4S3/c9-5-1-3-6(4-2-5)20(16,17)13-7-11-12-8(18-7)19(10,14)15/h1-4H,9H2,(H,11,13)(H2,10,14,15) BDLSLORLEPSOGW-UHFFFAOYSA-N 10870 2-N-(4-aminobenzene)-1,3,4-thiadiazole-2,5-disulfonamide::Aminobenzolamide 12::CHEMBL268439::aminobenzolamide 17a::aminobenzolamide deriv. 43::aromatic/heteroaromatic sulfonamide 15 Carbonic anhydrase 2 978 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10870&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 134560 46511441 CHEMBL268439 ZINC05579307 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903612 Nc1ccc(cc1)S(=O)(=O)NCc1ccc(cc1)S(N)(=O)=O InChI=1S/C13H15N3O4S2/c14-11-3-7-13(8-4-11)22(19,20)16-9-10-1-5-12(6-2-10)21(15,17)18/h1-8,16H,9,14H2,(H2,15,17,18) HHCXOFYGBAPOJR-UHFFFAOYSA-N 10871 4-amino-N-[(4-sulfamoylphenyl)methyl]benzene-1-sulfonamide::CHEMBL266026::aromatic/heteroaromatic sulfonamide 16 Carbonic anhydrase 2 3210 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10871&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 4422372 46511442 CHEMBL266026 ZINC06392199 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903613 Nc1ccc(cc1)S(=O)(=O)NCCc1ccc(cc1)S(N)(=O)=O InChI=1S/C14H17N3O4S2/c15-12-3-7-14(8-4-12)23(20,21)17-10-9-11-1-5-13(6-2-11)22(16,18)19/h1-8,17H,9-10,15H2,(H2,16,18,19) WODATDPNMUWSHD-UHFFFAOYSA-N 10872 4-amino-N-[2-(4-sulfamoylphenyl)ethyl]benzene-1-sulfonamide::CHEMBL7146::aromatic/heteroaromatic sulfonamide 17 Carbonic anhydrase 2 2290 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10872&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 9998322 46511443 CHEMBL7146 ZINC13488273 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903614 Nc1nccc(Nc2ccc(cc2)S(N)(=O)=O)n1 InChI=1S/C10H11N5O2S/c11-10-13-6-5-9(15-10)14-7-1-3-8(4-2-7)18(12,16)17/h1-6H,(H2,12,16,17)(H3,11,13,14,15) QOAXQANKSMHFKJ-UHFFFAOYSA-N 10873 4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonamide::CHEMBL6633::US9616064, Compound 1aa::aromatic/heteroaromatic sulfonamide 18 Carbonic anhydrase 2 2630 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10873&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 31036 46511444 CHEMBL6633 ZINC00056465 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903615 NS(=O)(=O)c1nnc(s1)-c1ccccc1Cl InChI=1S/C8H6ClN3O2S2/c9-6-4-2-1-3-5(6)7-11-12-8(15-7)16(10,13)14/h1-4H,(H2,10,13,14) PZVGOWIIHCUHAO-UHFFFAOYSA-N 10875 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide::CHEMBL360356::Chlorzolamide, CHL::JMC522226 Compound 19::JMC523116 Compound 19::aromatic/heteroaromatic sulfonamide 20 Carbonic anhydrase 2 45200 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10875 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10875&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search D9Z 4K0T,3D9Z,3DCC 165323 46511446 CHEMBL360356 DB07632 ZINC06095534 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903616 NS(=O)(=O)c1ccc(CO)cc1 InChI=1S/C7H9NO3S/c8-12(10,11)7-3-1-6(5-9)2-4-7/h1-4,9H,5H2,(H2,8,10,11) UULCVOIRJRJPQS-UHFFFAOYSA-N 10876 4-(hydroxymethyl)benzene-1-sulfonamide::CHEMBL6919::JMC522226 Compound 20::JMC523116 Compound 20::aromatic/heteroaromatic sulfonamide 21 Carbonic anhydrase 2 38300 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10876 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10876&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 10081162 46511447 CHEMBL6919 ZINC13442503 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903617 NS(=O)(=O)c1ccc(CCO)cc1 InChI=1S/C8H11NO3S/c9-13(11,12)8-3-1-7(2-4-8)5-6-10/h1-4,10H,5-6H2,(H2,9,11,12) RYKHXKKLCRPAJP-UHFFFAOYSA-N 10877 4-(2-hydroxyethyl)benzene-1-sulfonamide::CHEMBL6784::JMC522226 Compound 21::JMC523116 Compound 21::aromatic/heteroaromatic sulfonamide 22 Carbonic anhydrase 2 34500 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10877&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search S2O 6RG5,4YYT 10375558 46511448 CHEMBL6784 ZINC13442505 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903618 NS(=O)(=O)c1ccc(cc1)C(O)=O InChI=1S/C7H7NO4S/c8-13(11,12)6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)(H2,8,11,12) UCAGLBKTLXCODC-UHFFFAOYSA-N 4703 4-carboxybenzenesulfonamide 1::4-sulfamoylbenzoic acid::Benzoic Acid deriv. 31::CHEMBL414::JMC522226 Compound 22::JMC523116 Compound 22::JMC52646 Compound 23::aromatic/heteroaromatic sulfonamide 23 Carbonic anhydrase 2 39200 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=4703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=4703&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 4SO 6RFH,3R4G,5RSM 8739 8034358 CHEMBL414 ZINC00001099 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903619 CC(=O)Nc1nnc(s1)S(N)(=O)=O InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9) BZKPWHYZMXOIDC-UHFFFAOYSA-N 10880 AZA::AZA2::AZM acetazolamide::Acerazolamide, AAZ::Acetazolamide::Acetazolamide (AAZ)::Acetazolamide (AZA)::Acetazolamide (AZM)::Acetazolamide, 5::Acetazolamide, AAZ::Acetazolamide, AZA::Acetazolamide, AZM::CHEMBL20::N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide::Sulfonamide, 1::US10172837, Acetazolamide::US11278534, Example acetazolamide::US11535599, Example acetazolamide::sulfonamide 1 Carbonic anhydrase 2 9 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10880&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search AZM 4YGF,3W6H,3CZV,3V2J,3V2M,4G7A,4X5S,6QEB,1YDB,1YDA,1YDD,4LU3,3UCJ,4UOV,2UY4,4K0S,7COJ,4XIW,3HS4,4G0C,1DMY,1AZM,1JD0,1RJ6,1ZSB,2H4N,5JN8,8DYQ,3IAI,6IM3,5NEK,3DC3,2XTK,6MWJ,3ML5,6YMA 1986 46511450 27690 CHEMBL20 DB00819 6792 C06805 ZINC03813042 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903620 CC(=O)N=c1sc(nn1C)S(N)(=O)=O InChI=1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12) FLOSMHQXBMRNHR-UHFFFAOYSA-N 10881 CHEMBL288100::MZA3::Methazolamide::Methazolamide (MZA)::Methazolamide, MZA::N-[(2Z)-3-methyl-5-sulfamoyl-2,3-dihydro-1,3,4-thiadiazol-2-ylidene]acetamide::Sulfonamide, 2::cid_4100::sulfonamide 2 Carbonic anhydrase 2 660 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10881&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search MZM 4K0Z,4YHA,5KU6,1BZM,5C8I,3DAZ,3DCS 4100 46511451 CHEMBL288100 6828 ZINC12503151 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903621 CCOc1ccc2nc(sc2c1)S(N)(=O)=O InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) OUZWUKMCLIBBOG-UHFFFAOYSA-N 10882 6-ethoxy-1,3-benzothiazole-2-sulfonamide::CHEMBL18::Ethamide::Ethoxazolamide::Ethoxzolamide::Ethoxzolamide (EZA)::Ethoxzolamide, EZM::Sulfonamide, 3::US10172837, Ethoxyzolamide::sulfonamide 3 Carbonic anhydrase 2 27 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10882&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search EZL 3DD0,5JN9,3CAJ,3MDZ,6BCC,3DCW,6QL2,5TT3,6MWI 3295 46511452 101096 CHEMBL18 DB00311 6814 ZINC00056721 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903622 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) GJQPMPFPNINLKP-UHFFFAOYSA-N 10883 4,5-dichlorobenzene-1,3-disulfonamide::CHEMBL17::Dichlorophenamide::Dichlorophenamide (DCP)::Dichlorophenamide, DCP::Sulfonamide, 4::US10172837, Dichlorphenamide::sulfonamide 4 Carbonic anhydrase 2 2010 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10883&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search I7A 2POU 3038 46511453 101085 CHEMBL17 DB01144 6807 C07459 ZINC00896918 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903623 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1 IAVUPMFITXYVAF-XPUUQOCRSA-N 10884 (2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H-1,7-thieno[2,3-b]thiopyran-6-sulfonamide::Dorzolamide (DRZ)::Dorzolamide (DZA) Carbonic anhydrase 2 99 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10884&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search ETS 4M2W,4M2U,4K13,3FW3,6BC9,1CIL 5284549 46511454 4702 DB00869 6810 C06969 ZINC01530621 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903624 CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(N)(=O)=O InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 HCRKCZRJWPKOAR-JTQLQIEISA-N 10885 (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4H-1,7,2-thieno[3,2-e][1,2]thiazine-6-sulfonamide::(R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide::AL-4862::Azopt::Brinzolamide (BRZ)::brinzolamide Carbonic anhydrase 2 127 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10885&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search BZ1 3ZNC,4M2V,4M2R,6BBS 68844 46511455 3176 DB01194 6797 C07760 ZINC03953037 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903625 NS(=O)(=O)c1nnc(NS(=O)(=O)c2ccccc2)s1 InChI=1S/C8H8N4O4S3/c9-18(13,14)8-11-10-7(17-8)12-19(15,16)6-4-2-1-3-5-6/h1-5H,(H,10,12)(H2,9,13,14) PWDGTQXZLNDOKS-UHFFFAOYSA-N 10886 2-N-benzene-1,3,4-thiadiazole-2,5-disulfonamide::BZA1::Benzolamide::Benzolamide (BZA)::CHEMBL73962 Carbonic anhydrase 2 467 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10886&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3DB 3D8W,3DBU 18794 46511456 CHEMBL73962 DB07050 6920 ZINC04194731 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903626 CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 KJADKKWYZYXHBB-XBWDGYHZSA-N 10887 Sulfamate 7::Topiramate (TPM)::US11535599, Example topiramate::[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate Carbonic anhydrase 2 474 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10887&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search TOR 3LXE,3HKU,5JNA 5284627 46511457 63631 DB00273 6849 C07502 ZINC01530804 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903627 CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21) BGRJTUBHPOOWDU-UHFFFAOYSA-N 11638 CHEMBL26::Compound 7::N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide::SULPIRIDE,(+)::SULPIRIDE,(-)::Sulpiride::Sulpiride, SLP::Sulpiride-R::US10172837, Sulpiride Carbonic anhydrase 2 266 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11638&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 5355 46512161 32168 CHEMBL26 DB00391 5501 ZINC00057008 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903628 NS(=O)(=O)c1ccc(cc1)S(=O)(=O)Nc1cccc2c(Cl)c[nH]c12 InChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20) SETFNECMODOHTO-UHFFFAOYSA-N 10890 1-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide::CHEMBL77517::Compound 6::E7070::Indisulam (IND)::Sulfonamide, 7 Carbonic anhydrase 2 717 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10890&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search EF6 6UD7,6SJ7,6Q0W 216468 46511460 CHEMBL77517 7046 ZINC00600748 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903629 NS(=O)(=O)Cc1noc2ccccc12 InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12) UBQNRHZMVUUOMG-UHFFFAOYSA-N 10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS Carbonic anhydrase 2 876 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=10888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=10888&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search ZON 3PO7 5734 46511458 10127 CHEMBL750 DB00909 7047 C07504 ZINC00004321 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903630 Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) RZEKVGVHFLEQIL-UHFFFAOYSA-N 11639 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide::CHEMBL118::CLX::Celebrex::Celecoxib::US10322118, Urea-Based Scaffold Entry 9::US11478464, Compound Celecoxib::US8741944, Comparative Compound::US9388139, Celecoxib::cid_2662 Carbonic anhydrase 2 713 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11639&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search CEL 3LN1,3KK6,5JW1,7ZEJ,4FIM,1OQ5 2662 46512162 41423 CHEMBL118 DB00482 2892 C07589 ZINC02570895 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903631 Cc1onc(c1-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1 InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20) LNPDTQAFDNKSHK-UHFFFAOYSA-N 13063 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide::Bextra::CHEMBL865::VLX::Valdecoxib::cid_119607 Carbonic anhydrase 2 682 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13063&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search COX 2AW1 119607 46513481 63634 CHEMBL865 DB00580 2894 ZINC00006694 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903632 O=C1NS(=O)(=O)c2ccccc12 InChI=1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9) CVHZOJJKTDOEJC-UHFFFAOYSA-N 29278 CHEMBL310671::Garantose::SAC::Saccharimide::Saccharin Carbonic anhydrase 2 792 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29278&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search LSA 2Q38,7WJV,5RSP,4RIV,6FJJ,4N1O,3SRK,2Q1B 5143 81054707 32111 CHEMBL310671 5432 C12283 ZINC02560357 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50903634 NS(=O)(=O)c1ccc(cc1)N1CCCCS1(=O)=O InChI=1S/C10H14N2O4S2/c11-18(15,16)10-5-3-9(4-6-10)12-7-1-2-8-17(12,13)14/h3-6H,1-2,7-8H2,(H2,11,15,16) HMHVCUVYZFYAJI-UHFFFAOYSA-N 26999 4-(1,1-dioxo-1,2-thiazinan-2-yl)benzene-1-sulfonamide::CHEMBL328560::Contravul::Ospolot::Sulthiame (SLT)::Sulthiame, 2 Carbonic anhydrase 2 664 ChEMBL 10.1016/j.bmcl.2009.10.009 10.7270/Q27W6D4S 19846301 Carta, F; Maresca, A; Covarrubias, AS; Mowbray, SL; Jones, TA; Supuran, CT Universit£ degli Studi di Firenze http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26999&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search OSP 2Q1Q 5356 57298709 CHEMBL328560 DB08329 ZINC00002119 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50973149 Cc1ccc2-c3c(CSc2n1)cnn3-c1ccc(cc1)S(N)(=O)=O InChI=1S/C16H14N4O2S2/c1-10-2-7-14-15-11(9-23-16(14)19-10)8-18-20(15)12-3-5-13(6-4-12)24(17,21)22/h2-8H,9H2,1H3,(H2,17,21,22) BBYVQBNYXZIDGW-UHFFFAOYSA-N 50399075 CHEMBL2179304 Carbonic anhydrase 2 144 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399075 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399075&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search IE2 3QYK 56684131 163348099 CHEMBL2179304 ZINC95578669 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50973164 NS(=O)(=O)c1ccc(cc1)-n1ncc2CSc3ncccc3-c12 InChI=1S/C15H12N4O2S2/c16-23(20,21)12-5-3-11(4-6-12)19-14-10(8-18-19)9-22-15-13(14)2-1-7-17-15/h1-8H,9H2,(H2,16,20,21) HLIMRHGQWNYSKN-UHFFFAOYSA-N 50399076 CHEMBL2179305 Carbonic anhydrase 2 273 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399076 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399076&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 71450117 163348100 CHEMBL2179305 ZINC95573411 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50973179 NS(=O)(=O)c1ccc(cc1)-n1ncc2CSc3cc(ccc3-c12)C(F)(F)F InChI=1S/C17H12F3N3O2S2/c18-17(19,20)11-1-6-14-15(7-11)26-9-10-8-22-23(16(10)14)12-2-4-13(5-3-12)27(21,24)25/h1-8H,9H2,(H2,21,24,25) UIWAHXLXRURYJZ-UHFFFAOYSA-N 50399077 CHEMBL2179306 Carbonic anhydrase 2 357 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399077 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399077&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 71455488 163348101 CHEMBL2179306 ZINC95575122 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50973194 NS(=O)(=O)c1ccc(cc1)-n1ncc2CSc3cc(Cl)ccc3-c12 InChI=1S/C16H12ClN3O2S2/c17-11-1-6-14-15(7-11)23-9-10-8-19-20(16(10)14)12-2-4-13(5-3-12)24(18,21)22/h1-8H,9H2,(H2,18,21,22) OEZYKWLLDKHTRE-UHFFFAOYSA-N 50399078 CHEMBL2179307 Carbonic anhydrase 2 235 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399078&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 71457274 163348102 CHEMBL2179307 ZINC95573441 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50973209 COc1ccc2-c3c(CSc2c1)cnn3-c1ccc(cc1)S(N)(=O)=O InChI=1S/C17H15N3O3S2/c1-23-13-4-7-15-16(8-13)24-10-11-9-19-20(17(11)15)12-2-5-14(6-3-12)25(18,21)22/h2-9H,10H2,1H3,(H2,18,21,22) DMXTVXWEGNJBRF-UHFFFAOYSA-N 50399079 CHEMBL2179308 Carbonic anhydrase 2 610 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50399079 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50399079&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 71455489 163348103 CHEMBL2179308 ZINC95572827 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50973224 Cc1onc(c1-c1ccc(cc1)S(N)(=O)=O)-c1ccccc1 InChI=1S/C16H14N2O3S/c1-11-15(12-7-9-14(10-8-12)22(17,19)20)16(18-21-11)13-5-3-2-4-6-13/h2-10H,1H3,(H2,17,19,20) LNPDTQAFDNKSHK-UHFFFAOYSA-N 13063 4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonamide::Bextra::CHEMBL865::VLX::Valdecoxib::cid_119607 Carbonic anhydrase 2 682 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=13063 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=13063&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search COX 2AW1 119607 46513481 63634 CHEMBL865 DB00580 2894 ZINC00006694 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582 50973239 Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) RZEKVGVHFLEQIL-UHFFFAOYSA-N 11639 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide::CHEMBL118::CLX::Celebrex::Celecoxib::US10322118, Urea-Based Scaffold Entry 9::US11478464, Compound Celecoxib::US8741944, Comparative Compound::US9388139, Celecoxib::cid_2662 Carbonic anhydrase 2 713 ChEMBL 10.1021/jm300878g 10.7270/Q29S1S5G 23067387 Marini, AM; Maresca, A; Aggarwal, M; Orlandini, E; Nencetti, S; Da Settimo, F; Salerno, S; Simorini, F; La Motta, C; Taliani, S; Nuti, E; Scozzafava, A; McKenna, R; Rossello, A; Supuran, CT Universit£ di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=11639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10499&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=11639&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search CEL 3LN1,3KK6,5JW1,7ZEJ,4FIM,1OQ5 2662 46512162 41423 CHEMBL118 DB00482 2892 C07589 ZINC02570895 1 MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFGCADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIVVLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVDEFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHIGNIGEEV 1YM3,2A5V Carbonic anhydrase 2 MTCA2_MYCTU P9WPJ9 L0TFY5 O53573 Q7D582