BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 155745 NC(=N)NC(=O)c1nc(Cl)c(N)nc1N InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) XSDQTOBWRPYKKA-UHFFFAOYSA-N 16173 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride::3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide::Amiloride::Amipramidin::CHEMBL945 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.3109/10799899109064686 10.7270/Q2TH8K5J 1661335 Garritsen, A; Ijzerman, AP; Tulp, MT; Cragoe, EJ; Soudijn, W Center for Bio-Pharmaceutical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16173&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search AMR 4NTX,1F5L 16231 46516430 2639 CHEMBL945 2421 C06821 ZINC04340269 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155746 NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCc1ccccc1 InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22) KXDROGADUISDGY-UHFFFAOYSA-N 81819 Benzamil::CAS_1937-37-7::CHEMBL212579::NSC_108107 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.3109/10799899109064686 10.7270/Q2TH8K5J 1661335 Garritsen, A; Ijzerman, AP; Tulp, MT; Cragoe, EJ; Soudijn, W Center for Bio-Pharmaceutical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81819&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 108107 131342393 CHEMBL212579 4145 ZINC13548421 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155747 NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1 InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21) RQQJJXVETXFINY-UHFFFAOYSA-N 81818 CAS_1794::CHEMBL1909810::HMA::NSC_1794 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.3109/10799899109064686 10.7270/Q2TH8K5J 1661335 Garritsen, A; Ijzerman, AP; Tulp, MT; Cragoe, EJ; Soudijn, W Center for Bio-Pharmaceutical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81818&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1794 131342392 CHEMBL1909810 1192 ZINC03871091 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155748 NC(=N)NC(=O)c1nc(Cl)c(N)nc1N InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) XSDQTOBWRPYKKA-UHFFFAOYSA-N 16173 3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinamide;hydrochloride::3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide::Amiloride::Amipramidin::CHEMBL945 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.3109/10799899109064686 10.7270/Q2TH8K5J 1661335 Garritsen, A; Ijzerman, AP; Tulp, MT; Cragoe, EJ; Soudijn, W Center for Bio-Pharmaceutical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=16173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=16173&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search AMR 4NTX,1F5L 16231 46516430 2639 CHEMBL945 2421 C06821 ZINC04340269 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155749 NC(NC(=O)c1nc(Cl)c(N)nc1N)=NCc1ccccc1 InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22) KXDROGADUISDGY-UHFFFAOYSA-N 81819 Benzamil::CAS_1937-37-7::CHEMBL212579::NSC_108107 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.3109/10799899109064686 10.7270/Q2TH8K5J 1661335 Garritsen, A; Ijzerman, AP; Tulp, MT; Cragoe, EJ; Soudijn, W Center for Bio-Pharmaceutical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81819 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81819&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 108107 131342393 CHEMBL212579 4145 ZINC13548421 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155750 NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1 InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21) RQQJJXVETXFINY-UHFFFAOYSA-N 81818 CAS_1794::CHEMBL1909810::HMA::NSC_1794 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.3109/10799899109064686 10.7270/Q2TH8K5J 1661335 Garritsen, A; Ijzerman, AP; Tulp, MT; Cragoe, EJ; Soudijn, W Center for Bio-Pharmaceutical Sciences http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81818 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81818&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1794 131342392 CHEMBL1909810 1192 ZINC03871091 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157097 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 SNPPWIUOZRMYNY-UHFFFAOYSA-N 50048392 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one::BUPROPION::BUPROPION HYDROCHLORIDE::CHEMBL894::US9944618, Compound ID No. 176 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048392&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 444 103978858 3219 CHEMBL894 DB01156 7135 C06860 ZINC00057206 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157098 CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1 InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3 WSEQXVZVJXJVFP-UHFFFAOYSA-N 25870 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile::CHEMBL549::CITALOPRAM::CITALOPRAM HYDROBROMIDE::Escitalopram::[3H]Citalopram::[3H]Cytalopram::[3H]Escitalopram::[3H]Lexapro Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25870&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 68P 5I73,5I71,5I75 2771 56413158 3723 CHEMBL549 DB00215 4621 C07572 ZINC03800706 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157099 Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 NAUWTFJOPJWYOT-UHFFFAOYSA-N 22165 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine::CHEMBL153260::CHEMBL281594::CHEMBL542933::CHEMBL543876::GBR 12909::GBR-12909::NCGC00015300::US9944618, Compound ID No. 175::Vanoxerine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22165&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3455 49845980 64089 CHEMBL153260CHEMBL281594CHEMBL543876CHEMBL542933 ZINC22034135 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157100 CN(C)CCCN1c2ccccc2CCc2ccccc12 InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 BCGWQEUPMDMJNV-UHFFFAOYSA-N 50010859 CHEMBL11::IMIPRAMINE HYDROCHLORIDE::IMIPRAMINE PAMOATE::Imipramin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010859&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search IXX 2Q72,7LWD,6G9B 3696 103923605 47499 CHEMBL11 DB00458 357 C07049 ZINC00020245 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157101 CN1CC(c2ccccc2)c2cccc(N)c2C1 InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3 XXPANQJNYNUNES-UHFFFAOYSA-N 50005548 (+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::(+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::(-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::(Nomifensine) 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine (Nomifensine)::2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine(Nomifensine)::2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine::CHEMBL273575::NOMIFENSINE::NOMIFENSINE2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005548&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4528 103919027 116225 CHEMBL273575 DB04821 4792 ZINC19796035 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157102 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 SNPPWIUOZRMYNY-UHFFFAOYSA-N 50048392 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one::BUPROPION::BUPROPION HYDROCHLORIDE::CHEMBL894::US9944618, Compound ID No. 176 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048392 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048392&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 444 103978858 3219 CHEMBL894 DB01156 7135 C06860 ZINC00057206 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157103 CN(C)CCCC1(OCc2cc(ccc12)C#N)c1ccc(F)cc1 InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3 WSEQXVZVJXJVFP-UHFFFAOYSA-N 25870 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile::CHEMBL549::CITALOPRAM::CITALOPRAM HYDROBROMIDE::Escitalopram::[3H]Citalopram::[3H]Cytalopram::[3H]Escitalopram::[3H]Lexapro Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25870&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 68P 5I73,5I71,5I75 2771 56413158 3723 CHEMBL549 DB00215 4621 C07572 ZINC03800706 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157104 Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2 NAUWTFJOPJWYOT-UHFFFAOYSA-N 22165 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine::CHEMBL153260::CHEMBL281594::CHEMBL542933::CHEMBL543876::GBR 12909::GBR-12909::NCGC00015300::US9944618, Compound ID No. 175::Vanoxerine Gamma-aminobutyric acid receptor subunit alpha-1 8000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22165&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3455 49845980 64089 CHEMBL153260CHEMBL281594CHEMBL543876CHEMBL542933 ZINC22034135 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157105 CN(C)CCCN1c2ccccc2CCc2ccccc12 InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 BCGWQEUPMDMJNV-UHFFFAOYSA-N 50010859 CHEMBL11::IMIPRAMINE HYDROCHLORIDE::IMIPRAMINE PAMOATE::Imipramin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010859&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search IXX 2Q72,7LWD,6G9B 3696 103923605 47499 CHEMBL11 DB00458 357 C07049 ZINC00020245 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157106 CN1CC(c2ccccc2)c2cccc(N)c2C1 InChI=1S/C16H18N2/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18/h2-9,14H,10-11,17H2,1H3 XXPANQJNYNUNES-UHFFFAOYSA-N 50005548 (+)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::(+/-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::(-)-2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::(Nomifensine) 2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine::2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine (Nomifensine)::2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine(Nomifensine)::2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine::CHEMBL273575::NOMIFENSINE::NOMIFENSINE2-Methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-8-ylamine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90363-4 10.7270/Q28C9TR3 2530094 Andersen, PH Novo Industri A/S http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005548 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005548&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4528 103919027 116225 CHEMBL273575 DB04821 4792 ZINC19796035 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 157326 Cc1cccc2ccc(nc12)N1CCNCC1 InChI=1S/C14H17N3/c1-11-3-2-4-12-5-6-13(16-14(11)12)17-9-7-15-8-10-17/h2-6,15H,7-10H2,1H3 IJMBSHUIAAPNNP-UHFFFAOYSA-N 81957 QUIPAZINE,8-Me Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0014-2999(89)90802-9 10.7270/Q23R0RC5 2583244 Glennon, RA; Ismaiel, AE; McCarthy, BG; Peroutka, SJ Virginia Commonwealth University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81957&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 54592354 131342531 ZINC58020058 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 156371 C1CN(CCN1)c1cccc2OCCOc12 InChI=1S/C12H16N2O2/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12/h1-3,13H,4-9H2 WVLHGCRWEHCIOT-UHFFFAOYSA-N 50035057 (eltoprazine)1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazine::1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazine::CHEMBL282614::Eltoprazine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1515/dmdi.1990.8.1-2.85 10.7270/Q27M06DV 1982626 Schipper, J; Tulp, MT; Sijbesma, H Duphar B.V. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50035057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50035057&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 65853 103943127 CHEMBL282614 ZINC00001347 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 156381 C1CN(CCN1)c1cccc2OCCOc12 InChI=1S/C12H16N2O2/c1-2-10(14-6-4-13-5-7-14)12-11(3-1)15-8-9-16-12/h1-3,13H,4-9H2 WVLHGCRWEHCIOT-UHFFFAOYSA-N 50035057 (eltoprazine)1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazine::1-(2,3-Dihydro-benzo[1,4]dioxin-5-yl)-piperazine::CHEMBL282614::Eltoprazine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1515/dmdi.1990.8.1-2.85 10.7270/Q27M06DV 1982626 Schipper, J; Tulp, MT; Sijbesma, H Duphar B.V. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50035057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50035057&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 65853 103943127 CHEMBL282614 ZINC00001347 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155134 Oc1cc2CC[C@H]3NCc4ccccc4[C@H]3c2cc1O InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17+/m1/s1 BGOQGUHWXBGXJW-PBHICJAKSA-N 50010685 (+/-)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine::(6aR,12bR)-5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol::5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol::CHEMBL43345::Dihydrexidine, DHX Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q218350W 1352553 Mottola, DM; Brewster, WK; Cook, LL; Nichols, DE; Mailman, RB University of North Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010685&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 14708665 103923431 CHEMBL43345 ZINC26746099 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155135 Oc1cc2CC[C@H]3NCc4ccccc4[C@H]3c2cc1O InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2/t14-,17+/m1/s1 BGOQGUHWXBGXJW-PBHICJAKSA-N 50010685 (+/-)-trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine::(6aR,12bR)-5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol::5,6,6a,7,8,12b-Hexahydro-benzo[a]phenanthridine-10,11-diol::CHEMBL43345::Dihydrexidine, DHX Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q218350W 1352553 Mottola, DM; Brewster, WK; Cook, LL; Nichols, DE; Mailman, RB University of North Carolina http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010685 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010685&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 14708665 103923431 CHEMBL43345 ZINC26746099 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 154113 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 5080 PDSP Ki 10.1073/pnas.74.9.3805 10.7270/Q2Q23XR0 20632 Braestrup, C; Squires, RF TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 154114 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 2900 PDSP Ki 10.1073/pnas.74.9.3805 10.7270/Q2Q23XR0 20632 Braestrup, C; Squires, RF TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 154115 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 7900 PDSP Ki 10.1073/pnas.74.9.3805 10.7270/Q2Q23XR0 20632 Braestrup, C; Squires, RF TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 154116 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1073/pnas.74.9.3805 10.7270/Q2Q23XR0 20632 Braestrup, C; Squires, RF TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 154117 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 4.1 PDSP Ki 10.1073/pnas.74.9.3805 10.7270/Q2Q23XR0 20632 Braestrup, C; Squires, RF TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 154118 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 4.7 PDSP Ki 10.1073/pnas.74.9.3805 10.7270/Q2Q23XR0 20632 Braestrup, C; Squires, RF TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 154119 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 4.8 PDSP Ki 10.1073/pnas.74.9.3805 10.7270/Q2Q23XR0 20632 Braestrup, C; Squires, RF TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155502 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155503 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155504 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155505 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155509 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 18 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155510 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 3 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155511 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 3 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155512 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 4 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155516 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 27 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155517 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 7 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155518 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 9860 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 155519 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 9850 PDSP Ki 10.1016/0024-3205(91)90562-p 10.7270/Q2319TC5 1654492 Awad, M; Gavish, M Technion-Israel Institute of Technology http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 159811 CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(C1)c23 InChI=1S/C19H26N2O/c1-4-8-21(9-5-2)15-10-14-12-20-18-7-6-16(13(3)22)17(11-15)19(14)18/h6-7,12,15,20H,4-5,8-11H2,1-3H3 CKYZLYQSDNLGPT-UHFFFAOYSA-N 50094670 1-(4-Dipropylamino-1,3,4,5-tetrahydro-benzo[cd]indol-6-yl)-ethanone::CHEMBL276031::LY 293284::LY-293284::LY-293384 Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.7270/Q2805146 7523657 Foreman, MM; Fuller, RW; Rasmussen, K; Nelson, DL; Calligaro, DO; Zhang, L; Barrett, JE; Booher, RN; Paget, CJ; Flaugh, ME Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094670&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 18922713 103992546 CHEMBL276031 ZINC00005321 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 159812 CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(C1)c23 InChI=1S/C19H26N2O/c1-4-8-21(9-5-2)15-10-14-12-20-18-7-6-16(13(3)22)17(11-15)19(14)18/h6-7,12,15,20H,4-5,8-11H2,1-3H3 CKYZLYQSDNLGPT-UHFFFAOYSA-N 50094670 1-(4-Dipropylamino-1,3,4,5-tetrahydro-benzo[cd]indol-6-yl)-ethanone::CHEMBL276031::LY 293284::LY-293284::LY-293384 Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.7270/Q2805146 7523657 Foreman, MM; Fuller, RW; Rasmussen, K; Nelson, DL; Calligaro, DO; Zhang, L; Barrett, JE; Booher, RN; Paget, CJ; Flaugh, ME Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094670&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 18922713 103992546 CHEMBL276031 ZINC00005321 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 162788 Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12 InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3 MOZPSIXKYJUTKI-UHFFFAOYSA-N 29525 3H-GR113808::CHEMBL518682::GR 113808::[3H] GR 113808::[3H]GR113808 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1111/j.1476-5381.1994.tb14064.x 10.7270/Q2BG2MHG 8012715 Gale, JD; Grossman, CJ; Whitehead, JW; Oxford, AW; Bunce, KT; Humphrey, PP Glaxo Group Research Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29525&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 119376 81054954 73380 CHEMBL518682 259 ZINC00598220 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 162789 Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12 InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3 MOZPSIXKYJUTKI-UHFFFAOYSA-N 29525 3H-GR113808::CHEMBL518682::GR 113808::[3H] GR 113808::[3H]GR113808 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1111/j.1476-5381.1994.tb14064.x 10.7270/Q2BG2MHG 8012715 Gale, JD; Grossman, CJ; Whitehead, JW; Oxford, AW; Bunce, KT; Humphrey, PP Glaxo Group Research Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29525&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 119376 81054954 73380 CHEMBL518682 259 ZINC00598220 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160339 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 1306 PDSP Ki 10.1016/0922-4106(95)90014-4 10.7270/Q2XK8D2R 7664823 Giorgi, O; Lecca, D; Cancedda, E; Serra, GP; Corda, MG University of Cagliari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160340 CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3 PPTYJKAXVCCBDU-UHFFFAOYSA-N 25878 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL13280::Flunitrazepam::[3H]Rohypnol::[3H]flunitrazepam Gamma-aminobutyric acid receptor subunit alpha-1 1.37 PDSP Ki 10.1016/0922-4106(95)90014-4 10.7270/Q2XK8D2R 7664823 Giorgi, O; Lecca, D; Cancedda, E; Serra, GP; Corda, MG University of Cagliari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25878&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3380 56413166 CHEMBL13280 DB01544 4193 ZINC03812994 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160341 CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3 PPTYJKAXVCCBDU-UHFFFAOYSA-N 25878 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL13280::Flunitrazepam::[3H]Rohypnol::[3H]flunitrazepam Gamma-aminobutyric acid receptor subunit alpha-1 1.52 PDSP Ki 10.1016/0922-4106(95)90014-4 10.7270/Q2XK8D2R 7664823 Giorgi, O; Lecca, D; Cancedda, E; Serra, GP; Corda, MG University of Cagliari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25878&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3380 56413166 CHEMBL13280 DB01544 4193 ZINC03812994 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160342 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 26 PDSP Ki 10.1016/0922-4106(95)90014-4 10.7270/Q2XK8D2R 7664823 Giorgi, O; Lecca, D; Cancedda, E; Serra, GP; Corda, MG University of Cagliari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160343 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 332 PDSP Ki 10.1016/0922-4106(95)90014-4 10.7270/Q2XK8D2R 7664823 Giorgi, O; Lecca, D; Cancedda, E; Serra, GP; Corda, MG University of Cagliari http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 161753 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 InChI=1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1 YCXFHPUBGMMWJQ-PMERELPUSA-N 50056101 1-[(R)-2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-3-m-tolyl-urea::CHEMBL115121::YM022::YM022 Racemate Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2WD3Z2F 7910212 Nishida, A; Miyata, K; Tsutsumi, R; Yuki, H; Akuzawa, S; Kobayashi, A; Kamato, T; Ito, H; Yamano, M; Katuyama, Y Yamanouchi Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50056101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50056101&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122130 103952505 CHEMBL115121 888 ZINC03786250 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 161754 Cc1cccc(NC(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1 InChI=1S/C32H28N4O3/c1-21-11-10-15-24(19-21)33-32(39)35-30-31(38)36(20-28(37)25-16-7-6-12-22(25)2)27-18-9-8-17-26(27)29(34-30)23-13-4-3-5-14-23/h3-19,30H,20H2,1-2H3,(H2,33,35,39)/t30-/m0/s1 YCXFHPUBGMMWJQ-PMERELPUSA-N 50056101 1-[(R)-2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-3-m-tolyl-urea::CHEMBL115121::YM022::YM022 Racemate Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2WD3Z2F 7910212 Nishida, A; Miyata, K; Tsutsumi, R; Yuki, H; Akuzawa, S; Kobayashi, A; Kamato, T; Ito, H; Yamano, M; Katuyama, Y Yamanouchi Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50056101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50056101&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122130 103952505 CHEMBL115121 888 ZINC03786250 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 162975 CCN1CCN(CC1)c1cc(-c2ccc(F)cc2)c2CCCCCCc2n1 InChI=1S/C23H30FN3/c1-2-26-13-15-27(16-14-26)23-17-21(18-9-11-19(24)12-10-18)20-7-5-3-4-6-8-22(20)25-23/h9-12,17H,2-8,13-16H2,1H3 XVGOZDAJGBALKS-UHFFFAOYSA-N 50160807 4-(4-Fluoro-phenyl)-2-(4-propyl-piperazin-1-yl)-5,6,7,8,9,10-hexahydro-cycloocta[b]pyridine::AD-5423::Blonanserin::CHEMBL178803 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2TH8K60 8093723 Oka, M; Noda, Y; Ochi, Y; Furukawa, K; Une, T; Kurumiya, S; Hino, K; Karasawa, T Dainippon Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50160807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50160807&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 125564 104047267 CHEMBL178803 DB09223 ZINC00597434 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 161893 CCCCN1CCC(COC(=O)c2cc(Cl)c(N)c3OCCOc23)CC1 InChI=1S/C19H27ClN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3 AOOSJYIINXVNHV-UHFFFAOYSA-N 82505 CAS_121881::NSC_121881::SB204070 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1111/j.1476-5381.1994.tb13148.x 10.7270/Q2N0151D 7921604 Wardle, KA; Ellis, ES; Baxter, GS; Kennett, GA; Gaster, LM; Sanger, GJ SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82505&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 121881 136350476 256 ZINC01536586 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160852 O=C(NC1N=C(c2ccccc2)c2ccccc2NC1=O)c1cc2ccccc2[nH]1 InChI=1S/C24H18N4O2/c29-23(20-14-16-10-4-6-12-18(16)25-20)28-22-24(30)26-19-13-7-5-11-17(19)21(27-22)15-8-2-1-3-9-15/h1-14,22,25H,(H,26,30)(H,28,29) PQCDUNADCLPZMS-UHFFFAOYSA-N 50019252 1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide::1H-Indole-2-carboxylic acid (2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-amide: 0.2C4H10O::CCK antagonist synthetic 14::CHEMBL306760 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1073/pnas.83.13.4918 10.7270/Q2445K05 3014519 Evans, BE; Bock, MG; Rittle, KE; DiPardo, RM; Whitter, WL; Veber, DF; Anderson, PS; Freidinger, RM Merck Sharp & Dohme Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019252 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019252&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 14208192 103930242 CHEMBL306760 ZINC13601700 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160856 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 7 PDSP Ki 10.1073/pnas.83.13.4918 10.7270/Q2445K05 3014519 Evans, BE; Bock, MG; Rittle, KE; DiPardo, RM; Whitter, WL; Veber, DF; Anderson, PS; Freidinger, RM Merck Sharp & Dohme Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160860 Clc1ccc2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)N=C(c3ccccc3)c2c1 InChI=1S/C24H18ClN3O/c25-17-10-11-21-19(13-17)23(15-6-2-1-3-7-15)27-22(24(29)28-21)12-16-14-26-20-9-5-4-8-18(16)20/h1-11,13-14,22,26H,12H2,(H,28,29)/t22-/m1/s1 OAAIQFQHSUFGKD-JOCHJYFZSA-N 50019202 7-Chloro-3-(1H-indol-3-ylmethyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one::CCK antagonist synthetic 5::CHEMBL70728 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1073/pnas.83.13.4918 10.7270/Q2445K05 3014519 Evans, BE; Bock, MG; Rittle, KE; DiPardo, RM; Whitter, WL; Veber, DF; Anderson, PS; Freidinger, RM Merck Sharp & Dohme Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019202&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9865694 103930192 CHEMBL70728 ZINC02005677 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160861 Clc1ccc2NC(=O)[C@H](Cc3c[nH]c4ccccc34)N=C(c3ccccc3)c2c1 InChI=1S/C24H18ClN3O/c25-17-10-11-21-19(13-17)23(15-6-2-1-3-7-15)27-22(24(29)28-21)12-16-14-26-20-9-5-4-8-18(16)20/h1-11,13-14,22,26H,12H2,(H,28,29)/t22-/m0/s1 OAAIQFQHSUFGKD-QFIPXVFZSA-N 82390 CCK antagonist synthetic 6 Gamma-aminobutyric acid receptor subunit alpha-1 5600 PDSP Ki 10.1073/pnas.83.13.4918 10.7270/Q2445K05 3014519 Evans, BE; Bock, MG; Rittle, KE; DiPardo, RM; Whitter, WL; Veber, DF; Anderson, PS; Freidinger, RM Merck Sharp & Dohme Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82390 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82390&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 39760 136350361 ZINC05850696 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 160862 O=C1Nc2ccccc2C(=N[C@@H]1Cc1c[nH]c2ccccc12)c1ccccc1 InChI=1S/C24H19N3O/c28-24-22(14-17-15-25-20-12-6-4-10-18(17)20)26-23(16-8-2-1-3-9-16)19-11-5-7-13-21(19)27-24/h1-13,15,22,25H,14H2,(H,27,28)/t22-/m1/s1 FAERGZYQYDZYEL-JOCHJYFZSA-N 82391 CCK antagonist synthetic 8 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1073/pnas.83.13.4918 10.7270/Q2445K05 3014519 Evans, BE; Bock, MG; Rittle, KE; DiPardo, RM; Whitter, WL; Veber, DF; Anderson, PS; Freidinger, RM Merck Sharp & Dohme Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82391 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82391&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 15614807 136350362 ZINC28241356 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172197 Cn1ccc2cc3N(CCc3cc12)C(=O)Nc1cccnc1 InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22) QJQORSLQNXDVGE-UHFFFAOYSA-N 50060417 5-Methyl-3,5-dihydro-2H-pyrrolo[2,3-f]indole-1-carboxylic acid pyridin-3-ylamide::CHEMBL297784::SB 206553::SB-206553 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1111/j.1476-5381.1996.tb15208.x 10.7270/Q27W69Q5 8821530 Kennett, GA; Wood, MD; Bright, F; Cilia, J; Piper, DC; Gager, T; Thomas, D; Baxter, GS; Forbes, IT; Ham, P; Blackburn, TP SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060417&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5163 103956180 CHEMBL297784 189 C11740 ZINC00005994 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172199 Cn1ccc2cc3N(CCc3cc12)C(=O)Nc1cccnc1 InChI=1S/C17H16N4O/c1-20-7-4-12-10-16-13(9-15(12)20)5-8-21(16)17(22)19-14-3-2-6-18-11-14/h2-4,6-7,9-11H,5,8H2,1H3,(H,19,22) QJQORSLQNXDVGE-UHFFFAOYSA-N 50060417 5-Methyl-3,5-dihydro-2H-pyrrolo[2,3-f]indole-1-carboxylic acid pyridin-3-ylamide::CHEMBL297784::SB 206553::SB-206553 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1111/j.1476-5381.1996.tb15208.x 10.7270/Q27W69Q5 8821530 Kennett, GA; Wood, MD; Bright, F; Cilia, J; Piper, DC; Gager, T; Thomas, D; Baxter, GS; Forbes, IT; Ham, P; Blackburn, TP SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50060417 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50060417&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5163 103956180 CHEMBL297784 189 C11740 ZINC00005994 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 171461 NC(SCCCc1cnc[nH]1)=NCCc1ccc(I)cc1 InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20) UBHYDQAARZKHEZ-UHFFFAOYSA-N 22913 CHEMBL1237146::CHEMBL498770::Iodophenpropit::{[3-(1H-imidazol-5-yl)propyl]sulfanyl}-N''-[2-(4-iodophenyl)ethyl]methanimidamide Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1111/j.1476-5381.1995.tb15071.x 10.7270/Q2ZK5F64 8564266 Leurs, R; Tulp, MT; Menge, WM; Adolfs, MJ; Zuiderveld, OP; Timmerman, H Vrije Universiteit http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22913&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3035746 49846727 CHEMBL498770CHEMBL1237146 ZINC14979644 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 171462 S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1 InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) QKDDJDBFONZGBW-UHFFFAOYSA-N 22914 CHEMBL260374::N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide::Thioperamide::US11622967, Compound Thioperamide Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1111/j.1476-5381.1995.tb15071.x 10.7270/Q2ZK5F64 8564266 Leurs, R; Tulp, MT; Menge, WM; Adolfs, MJ; Zuiderveld, OP; Timmerman, H Vrije Universiteit http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22914&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search FJZ 3MDM 3035905 49846728 CHEMBL260374 1267 ZINC13108134 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 171463 NC(SCCCc1cnc[nH]1)=NCCc1ccc(I)cc1 InChI=1S/C15H19IN4S/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20) UBHYDQAARZKHEZ-UHFFFAOYSA-N 22913 CHEMBL1237146::CHEMBL498770::Iodophenpropit::{[3-(1H-imidazol-5-yl)propyl]sulfanyl}-N''-[2-(4-iodophenyl)ethyl]methanimidamide Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1111/j.1476-5381.1995.tb15071.x 10.7270/Q2ZK5F64 8564266 Leurs, R; Tulp, MT; Menge, WM; Adolfs, MJ; Zuiderveld, OP; Timmerman, H Vrije Universiteit http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22913 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22913&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3035746 49846727 CHEMBL498770CHEMBL1237146 ZINC14979644 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 171464 S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1 InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) QKDDJDBFONZGBW-UHFFFAOYSA-N 22914 CHEMBL260374::N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide::Thioperamide::US11622967, Compound Thioperamide Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1111/j.1476-5381.1995.tb15071.x 10.7270/Q2ZK5F64 8564266 Leurs, R; Tulp, MT; Menge, WM; Adolfs, MJ; Zuiderveld, OP; Timmerman, H Vrije Universiteit http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22914 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22914&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search FJZ 3MDM 3035905 49846728 CHEMBL260374 1267 ZINC13108134 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170593 Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12 InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3 VREFGVBLTWBCJP-UHFFFAOYSA-N 50001728 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine::8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::ALPRAZOLAM::CHEMBL661::Xanax Gamma-aminobutyric acid receptor subunit alpha-1 21 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001728&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 08H 6HUO,3U5J 2118 103916140 2611 CHEMBL661 DB00404 7111 C06817 ZINC00000903 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170594 Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12 InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3 VREFGVBLTWBCJP-UHFFFAOYSA-N 50001728 8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,4)benzodiazepine::8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::ALPRAZOLAM::CHEMBL661::Xanax Gamma-aminobutyric acid receptor subunit alpha-1 65 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001728&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 08H 6HUO,3U5J 2118 103916140 2611 CHEMBL661 DB00404 7111 C06817 ZINC00000903 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170595 CC(C)(C)OC(=O)c1ncn-2c1C1CCCN1C(=O)c1c(Br)cccc-21 InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3 LWUDDYHYYNNIQI-UHFFFAOYSA-N 50017320 8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-triaza-benzo[g]cyclopenta[e]azulene-3-carboxylic acid tert-butyl ester::Bretazenil::CHEMBL444045::Ro-16-6028 Gamma-aminobutyric acid receptor subunit alpha-1 2.6 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017320&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9823370 103928588 CHEMBL444045 ZINC11616881 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170596 CC(C)(C)OC(=O)c1ncn-2c1C1CCCN1C(=O)c1c(Br)cccc-21 InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3 LWUDDYHYYNNIQI-UHFFFAOYSA-N 50017320 8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-triaza-benzo[g]cyclopenta[e]azulene-3-carboxylic acid tert-butyl ester::Bretazenil::CHEMBL444045::Ro-16-6028 Gamma-aminobutyric acid receptor subunit alpha-1 1.5 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017320&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9823370 103928588 CHEMBL444045 ZINC11616881 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170597 CC(C)(C)OC(=O)c1ncn-2c1C1CCCN1C(=O)c1c(Br)cccc-21 InChI=1S/C19H20BrN3O3/c1-19(2,3)26-18(25)15-16-13-8-5-9-22(13)17(24)14-11(20)6-4-7-12(14)23(16)10-21-15/h4,6-7,10,13H,5,8-9H2,1-3H3 LWUDDYHYYNNIQI-UHFFFAOYSA-N 50017320 8-Bromo-7-oxo-3b,4,5,6-tetrahydro-7H-2,6a,11b-triaza-benzo[g]cyclopenta[e]azulene-3-carboxylic acid tert-butyl ester::Bretazenil::CHEMBL444045::Ro-16-6028 Gamma-aminobutyric acid receptor subunit alpha-1 97 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017320 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017320&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9823370 103928588 CHEMBL444045 ZINC11616881 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170598 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 42 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170599 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 38 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170600 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 43 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170601 NC(=O)c1ncn-2c1CN=C(c1ccccc1Br)c1cc(F)ccc-21 InChI=1S/C18H12BrFN4O/c19-13-4-2-1-3-11(13)16-12-7-10(20)5-6-14(12)24-9-23-17(18(21)25)15(24)8-22-16/h1-7,9H,8H2,(H2,21,25) OCJHYHKWUWSHEN-UHFFFAOYSA-N 84740 CAS_119194::Imidazenil::NSC_119194 Gamma-aminobutyric acid receptor subunit alpha-1 1 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84740&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 119194 136350840 ZINC00598740 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170602 NC(=O)c1ncn-2c1CN=C(c1ccccc1Br)c1cc(F)ccc-21 InChI=1S/C18H12BrFN4O/c19-13-4-2-1-3-11(13)16-12-7-10(20)5-6-14(12)24-9-23-17(18(21)25)15(24)8-22-16/h1-7,9H,8H2,(H2,21,25) OCJHYHKWUWSHEN-UHFFFAOYSA-N 84740 CAS_119194::Imidazenil::NSC_119194 Gamma-aminobutyric acid receptor subunit alpha-1 0.9 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84740&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 119194 136350840 ZINC00598740 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 170603 NC(=O)c1ncn-2c1CN=C(c1ccccc1Br)c1cc(F)ccc-21 InChI=1S/C18H12BrFN4O/c19-13-4-2-1-3-11(13)16-12-7-10(20)5-6-14(12)24-9-23-17(18(21)25)15(24)8-22-16/h1-7,9H,8H2,(H2,21,25) OCJHYHKWUWSHEN-UHFFFAOYSA-N 84740 CAS_119194::Imidazenil::NSC_119194 Gamma-aminobutyric acid receptor subunit alpha-1 38 PDSP Ki 10.7270/Q2Q81BK1 8394902 Giusti, P; Ducić, I; Puia, G; Arban, R; Walser, A; Guidotti, A; Costa, E Georgetown University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84740&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 119194 136350840 ZINC00598740 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172124 Cc1cc(NC(=O)Nc2ccc3n(C)ccc3c2)sn1 InChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19) USFUFHFQWXDVMH-UHFFFAOYSA-N 84991 CAS_3277600::NSC_3277600::SB204741 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/0166-4328(96)00087-3 10.7270/Q2RX99ND 8788493 Baxter, GS SmithKline Beecham Pharmaceuticals Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84991&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3277600 136351091 221 ZINC00016912 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173428 CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) NTJOBXMMWNYJFB-UHFFFAOYSA-N 81790 Amisulpride::CAS_71675-85-9::NSC_2159::US10167256, Amisulpride::US10259786, Amisulpride Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81790&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2159 131342364 64045 DB06288 963 ZINC01846088 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173429 CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 ZUXABONWMNSFBN-UHFFFAOYSA-N 22869 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene::CLOZARIL::Clozapine::Leponex::US10259786, Clozapine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22869&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2818 49846683 38 ZINC19796155 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173430 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 LNEPOXFFQSENCJ-UHFFFAOYSA-N 21398 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)::4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one::CHEMBL54::CHEMBL545608::Haloperidol::Haloperidol, 1 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21398&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search GMJ 6X10,6DJZ,6LUQ 3559 49689470 5613 CHEMBL54CHEMBL545608 DB00502 86 C01814 ZINC00537822 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173431 CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) NTJOBXMMWNYJFB-UHFFFAOYSA-N 81790 Amisulpride::CAS_71675-85-9::NSC_2159::US10167256, Amisulpride::US10259786, Amisulpride Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81790&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2159 131342364 64045 DB06288 963 ZINC01846088 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173432 CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 ZUXABONWMNSFBN-UHFFFAOYSA-N 22869 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene::CLOZARIL::Clozapine::Leponex::US10259786, Clozapine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22869&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2818 49846683 38 ZINC19796155 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173433 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 LNEPOXFFQSENCJ-UHFFFAOYSA-N 21398 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)::4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one::CHEMBL54::CHEMBL545608::Haloperidol::Haloperidol, 1 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21398&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search GMJ 6X10,6DJZ,6LUQ 3559 49689470 5613 CHEMBL54CHEMBL545608 DB00502 86 C01814 ZINC00537822 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 174740 CP(O)(=O)CCC=N InChI=1S/C4H10NO2P/c1-8(6,7)4-2-3-5/h3,5H,2,4H2,1H3,(H,6,7) CLJLMKDNJNIXPO-UHFFFAOYSA-N 50032973 ((Z)-3-Amino-propenyl)-methyl-phosphinic acid::3-aminoprop-1-enyl(methyl)phosphinic acid::CGP44530::CGP70523::CHEMBL109375::CHEMBL430510 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2H41PZV 9226416 Chebib, M; Vandenberg, RJ; Froestl, W; Johnston, GA University of Sydney http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032973&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91929120 103941345 CHEMBL430510CHEMBL109375 ZINC13742964 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 174741 NCCCP(=O)=O InChI=1S/C3H8NO2P/c4-2-1-3-7(5)6/h1-4H2 MQIWYGZSHIXQIU-UHFFFAOYSA-N 50032962 ((Z)-3-Amino-propenyl)-phosphinic acid::CGP38593::CGP70522::CHEMBL113217::CHEMBL324917 Gamma-aminobutyric acid receptor subunit alpha-1 6600 PDSP Ki 10.7270/Q2H41PZV 9226416 Chebib, M; Vandenberg, RJ; Froestl, W; Johnston, GA University of Sydney http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032962 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032962&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 54085786 103941334 CHEMBL324917CHEMBL113217 ZINC13742935 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 174742 CP(O)(=O)CCC=N InChI=1S/C4H10NO2P/c1-8(6,7)4-2-3-5/h3,5H,2,4H2,1H3,(H,6,7) CLJLMKDNJNIXPO-UHFFFAOYSA-N 50032973 ((Z)-3-Amino-propenyl)-methyl-phosphinic acid::3-aminoprop-1-enyl(methyl)phosphinic acid::CGP44530::CGP70523::CHEMBL109375::CHEMBL430510 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2H41PZV 9226416 Chebib, M; Vandenberg, RJ; Froestl, W; Johnston, GA University of Sydney http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50032973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50032973&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91929120 103941345 CHEMBL430510CHEMBL109375 ZINC13742964 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175087 NC(=O)c1ccc(F)c2OCC(Cc12)N(C1CCC1)C1CCC1 InChI=1S/C18H23FN2O2/c19-16-8-7-14(18(20)22)15-9-13(10-23-17(15)16)21(11-3-1-4-11)12-5-2-6-12/h7-8,11-13H,1-6,9-10H2,(H2,20,22) MQTUXRKNJYPMCG-UHFFFAOYSA-N 85190 CAS_3055171::NAD-299::NSC_3055171 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q22Z142T 9336327 Johansson, L; Sohn, D; Thorberg, SO; Jackson, DM; Kelder, D; Larsson, LG; Renyi, L; Ross, SB; Wallsten, C; Eriksson, H; Hu, PS; Jerning, E; Mohell, N; Westlind-Danielsson, A Preclinical R & D, Astra Arcus AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85190&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 12016890 136351290 82 ZINC04631259 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175088 COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1 InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3 SBPRIAGPYFYCRT-UHFFFAOYSA-N 86708 CAS_146714-97-8::CHEMBL31354::CHEMBL514874::CHEMBL537403::NSC_104911::WAY 100,635 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q22Z142T 9336327 Johansson, L; Sohn, D; Thorberg, SO; Jackson, DM; Kelder, D; Larsson, LG; Renyi, L; Ross, SB; Wallsten, C; Eriksson, H; Hu, PS; Jerning, E; Mohell, N; Westlind-Danielsson, A Preclinical R & D, Astra Arcus AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86708&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5684 136352757 CHEMBL537403CHEMBL514874CHEMBL31354 ZINC52541473 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175089 NC(=O)c1ccc(F)c2OCC(Cc12)N(C1CCC1)C1CCC1 InChI=1S/C18H23FN2O2/c19-16-8-7-14(18(20)22)15-9-13(10-23-17(15)16)21(11-3-1-4-11)12-5-2-6-12/h7-8,11-13H,1-6,9-10H2,(H2,20,22) MQTUXRKNJYPMCG-UHFFFAOYSA-N 85190 CAS_3055171::NAD-299::NSC_3055171 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q22Z142T 9336327 Johansson, L; Sohn, D; Thorberg, SO; Jackson, DM; Kelder, D; Larsson, LG; Renyi, L; Ross, SB; Wallsten, C; Eriksson, H; Hu, PS; Jerning, E; Mohell, N; Westlind-Danielsson, A Preclinical R & D, Astra Arcus AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85190&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 12016890 136351290 82 ZINC04631259 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175090 COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1 InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3 SBPRIAGPYFYCRT-UHFFFAOYSA-N 86708 CAS_146714-97-8::CHEMBL31354::CHEMBL514874::CHEMBL537403::NSC_104911::WAY 100,635 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q22Z142T 9336327 Johansson, L; Sohn, D; Thorberg, SO; Jackson, DM; Kelder, D; Larsson, LG; Renyi, L; Ross, SB; Wallsten, C; Eriksson, H; Hu, PS; Jerning, E; Mohell, N; Westlind-Danielsson, A Preclinical R & D, Astra Arcus AB http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86708&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5684 136352757 CHEMBL537403CHEMBL514874CHEMBL31354 ZINC52541473 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175178 CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) GKWHICIUSVVNGX-UHFFFAOYSA-N 85195 CAS_5311097::LY 344864::NSC_5311097 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0024-3205(97)00885-0 10.7270/Q2F47MNN 9395253 Phebus, LA; Johnson, KW; Zgombick, JM; Gilbert, PJ; Van Belle, K; Mancuso, V; Nelson, DL; Calligaro, DO; Kiefer, AD; Branchek, TA; Flaugh, ME Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85195&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 18971832 136351295 21 ZINC13831212 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175179 CN(C)C1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26) GKWHICIUSVVNGX-UHFFFAOYSA-N 85195 CAS_5311097::LY 344864::NSC_5311097 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0024-3205(97)00885-0 10.7270/Q2F47MNN 9395253 Phebus, LA; Johnson, KW; Zgombick, JM; Gilbert, PJ; Van Belle, K; Mancuso, V; Nelson, DL; Calligaro, DO; Kiefer, AD; Branchek, TA; Flaugh, ME Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85195&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 18971832 136351295 21 ZINC13831212 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172694 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 46.3 PDSP Ki 10.1074/jbc.271.44.27902 10.7270/Q2FF3QV5 8910390 Araujo, F; Tan, S; Ruano, D; Schoemaker, H; Benavides, J; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172695 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 173.5 PDSP Ki 10.1074/jbc.271.44.27902 10.7270/Q2FF3QV5 8910390 Araujo, F; Tan, S; Ruano, D; Schoemaker, H; Benavides, J; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172696 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 190 PDSP Ki 10.1074/jbc.271.44.27902 10.7270/Q2FF3QV5 8910390 Araujo, F; Tan, S; Ruano, D; Schoemaker, H; Benavides, J; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172697 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 13 PDSP Ki 10.1074/jbc.271.44.27902 10.7270/Q2FF3QV5 8910390 Araujo, F; Tan, S; Ruano, D; Schoemaker, H; Benavides, J; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172698 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 56.2 PDSP Ki 10.1074/jbc.271.44.27902 10.7270/Q2FF3QV5 8910390 Araujo, F; Tan, S; Ruano, D; Schoemaker, H; Benavides, J; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172699 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 1840 PDSP Ki 10.1074/jbc.271.44.27902 10.7270/Q2FF3QV5 8910390 Araujo, F; Tan, S; Ruano, D; Schoemaker, H; Benavides, J; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172700 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 39.6 PDSP Ki 10.1074/jbc.271.44.27902 10.7270/Q2FF3QV5 8910390 Araujo, F; Tan, S; Ruano, D; Schoemaker, H; Benavides, J; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172701 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 424 PDSP Ki 10.1074/jbc.271.44.27902 10.7270/Q2FF3QV5 8910390 Araujo, F; Tan, S; Ruano, D; Schoemaker, H; Benavides, J; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172702 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 5 PDSP Ki 10.1074/jbc.271.44.27902 10.7270/Q2FF3QV5 8910390 Araujo, F; Tan, S; Ruano, D; Schoemaker, H; Benavides, J; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172707 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 27 PDSP Ki 10.7270/Q29P305P 8930187 Hoogerkamp, A; Arends, RH; Bomers, AM; Mandema, JW; Voskuyl, RA; Danhof, M Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172708 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 53 PDSP Ki 10.7270/Q29P305P 8930187 Hoogerkamp, A; Arends, RH; Bomers, AM; Mandema, JW; Voskuyl, RA; Danhof, M Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172709 CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3 PPTYJKAXVCCBDU-UHFFFAOYSA-N 25878 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL13280::Flunitrazepam::[3H]Rohypnol::[3H]flunitrazepam Gamma-aminobutyric acid receptor subunit alpha-1 29 PDSP Ki 10.7270/Q29P305P 8930187 Hoogerkamp, A; Arends, RH; Bomers, AM; Mandema, JW; Voskuyl, RA; Danhof, M Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25878&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3380 56413166 CHEMBL13280 DB01544 4193 ZINC03812994 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172710 Cc1ncc2CN=C(c3ccccc3F)c3cc(Cl)ccc3-n12 InChI=1S/C18H13ClFN3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3 DDLIGBOFAVUZHB-UHFFFAOYSA-N 21363 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene::8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine::CHEMBL655::Dormicum::Midazolam::Ro 21-3981 Gamma-aminobutyric acid receptor subunit alpha-1 26 PDSP Ki 10.7270/Q29P305P 8930187 Hoogerkamp, A; Arends, RH; Bomers, AM; Mandema, JW; Voskuyl, RA; Danhof, M Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21363&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 08J 5TE8,3U5K 4192 49689435 CHEMBL655 DB00683 3342 C07524 ZINC00001732 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 172711 OC1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,20H,(H,17,19) ADIMAYPTOBDMTL-UHFFFAOYSA-N 85031 CAS_604-75-1::NSC_4616::Oxazepam Gamma-aminobutyric acid receptor subunit alpha-1 350 PDSP Ki 10.7270/Q29P305P 8930187 Hoogerkamp, A; Arends, RH; Bomers, AM; Mandema, JW; Voskuyl, RA; Danhof, M Leiden University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85031 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85031&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4616 136351131 7823 DB00842 C07359 ZINC00509440 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173116 Cc1nc2C(O)CCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12 InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3 PMXMIIMHBWHSKN-UHFFFAOYSA-N 50252513 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one::9-OH-risperidone::9-hydroxy risperidone::CHEMBL1621::Invega::PALIPERIDONE Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50252513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50252513&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search K4I 115237 104105311 CHEMBL1621 DB01267 7258 ZINC04214700 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173117 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 2.4 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173118 CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 ZUXABONWMNSFBN-UHFFFAOYSA-N 22869 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene::CLOZARIL::Clozapine::Leponex::US10259786, Clozapine Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22869&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2818 49846683 38 ZINC19796155 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173119 Fc1ccc(cc1)C(CCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc(F)cc1 InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35) QOYHHIBFXOOADH-UHFFFAOYSA-N 26948 8-[4,4-bis(4-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::CHEMBL46516::FLUSPIRILENE::NCGC00015424::cid_3396::med.21724, Compound Fluspirilene::spiropiperidine analogue, 1 Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26948&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3396 57298659 CHEMBL46516 DB04842 85 ZINC00537755 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173120 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 LNEPOXFFQSENCJ-UHFFFAOYSA-N 21398 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)::4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one::CHEMBL54::CHEMBL545608::Haloperidol::Haloperidol, 1 Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21398&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search GMJ 6X10,6DJZ,6LUQ 3559 49689470 5613 CHEMBL54CHEMBL545608 DB00502 86 C01814 ZINC00537822 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173121 CN1CCN(CC1)C1=c2cc(C)sc2=Nc2ccccc2N1 InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,18H,7-10H2,1-2H3 WXPNDRBBWZMPQG-UHFFFAOYSA-N 82479 CAS_132539-06-1::NSC_4585::OLANZAPINE::USRE49340, Rank 2 Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82479&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4585 136350450 47 ZINC03873830 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173122 CN1CC2C(C1)c1cc(Cl)ccc1Oc1ccccc21 InChI=1S/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3 VSWBSWWIRNCQIJ-UHFFFAOYSA-N 84994 CAS_163091::NSC_163091::ORG-5222 Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84994 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84994&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9903970 136351094 71255 DB06216 ZINC11677376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173123 NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N1CCCCC1 InChI=1S/C21H30FN3O2/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25/h6-9H,1-5,10-16H2,(H2,23,27) AXKPFOAXAHJUAG-UHFFFAOYSA-N 81483 CAS_1893-33-0::NSC_4830::PIPAMPERONE Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81483&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4830 131342057 DB09286 92 ZINC21297287 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173124 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12 InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2 URKOMYMAXPYINW-UHFFFAOYSA-N 50095890 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol::2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-ylpiperazin-1-yl)ethoxy]ethanol::CHEMBL716::QUETIAPINE Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50095890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50095890&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5002 103993497 8707 CHEMBL716 DB01224 50 C07397 ZINC19632628 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173125 Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12 InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3 RAPZEAPATHNIPO-UHFFFAOYSA-N 50001885 (risperidone)3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one::1-(2-Allyl-phenoxy)-3-isopropylamino-propan-2-ol::2-(2-(4-(benzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-7,8,9,9a-tetrahydro-1H-pyrido[1,2-a]pyrimidin-4(6H)-one::2-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-6,7,8,8a-tetrahydro-5H-naphthalen-1-one::3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one::3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one::3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (Resperidone)::3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one (risperidone)::3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one(risperidone)::5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-methyl-1,3-dihydro-indol-2-one(Norastemizole)::CHEMBL85::R 64 766::RISPERDAL::RISPERIDONE::US10167256, Risperidone::US10174011, risperidone::US10259786, Risperidone::US10501452, Compound risperidone::US8802672, Risperidone::WO2023288027, Cmpd Risperidone Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001885&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 8NU 6A93,6CM4 5073 103916252 8871 CHEMBL85 DB00734 96 ZINC00538312 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173126 Fc1ccc(cc1)-n1cc(C2CCN(CCN3CCNC3=O)CC2)c2cc(Cl)ccc12 InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31) GZKLJWGUPQBVJQ-UHFFFAOYSA-N 50001786 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one::1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one::CHEMBL12713::Sertindole Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001786&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 60149 103916159 9122 CHEMBL12713 DB06144 98 C07567 ZINC00538337 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173127 Clc1cc2NC(=O)Cc2cc1CCN1CCN(CC1)c1nsc2ccccc12 InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27) MVWVFYHBGMAFLY-UHFFFAOYSA-N 50048803 5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one::5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3-dihydro-indol-2-one::5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3-dihydro-indol-2-one (Ziprasidone)::5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3-dihydro-indol-2-one(Norastemizole)::CHEMBL708::GEODON::ZIPRASIDONE::ZIPRASIDONE HYDROCHLORIDE Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048803&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 60854 103979184 10119 CHEMBL708 DB00246 59 C07568 ZINC00538550 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173128 CN(C)CCOC1=Cc2ccccc2Sc2ccc(Cl)cc12 InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3 HDOZVRUNCMBHFH-UHFFFAOYSA-N 35255 2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-thiepin::2-Chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin::2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine::CHEMBL285802::Nipolept::Zoleptil::zotepine Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1007/bf02245606 10.7270/Q2610XV6 8935801 Schotte, A; Janssen, PF; Gommeren, W; Luyten, WH; Van Gompel, P; Lesage, AS; De Loore, K; Leysen, JE Janssen Research Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35255 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35255&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search ZOT 6A94 5736 85753334 32316 CHEMBL285802 DB09225 103 ZINC00002264 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175639 CCOC(=O)c1cc2c(cn1)[nH]c1ccccc21 InChI=1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3 KOVRZNUMIKACTB-UHFFFAOYSA-N 50244035 Beta CCE::CHEMBL454606::cid_105078::ethyl 9H-pyrido[3,4-b]indole-3-carboxylate Gamma-aminobutyric acid receptor subunit alpha-1 2920 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50244035 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50244035&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 105078 104100165 CHEMBL454606 ZINC06507046 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175640 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175641 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175642 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 644 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175643 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 3860 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175644 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175645 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175646 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 18.6 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175647 [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1 InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) DGBIGWXXNGSACT-UHFFFAOYSA-N 50019213 1,3-dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one::5-(2-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one::CHEMBL452::CLONAZEPAM Gamma-aminobutyric acid receptor subunit alpha-1 33.4 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50019213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50019213&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2802 103930203 3756 CHEMBL452 DB01068 6963 ZINC03813003 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175648 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 12 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175649 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 30.8 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175650 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 180 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175651 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 193 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175652 OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 IZEKFCXSFNUWAM-UHFFFAOYSA-N 23620 2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol::CHEMBL932::Dipyridamine::Dipyridamole::Dipyudamine::MLS000028420::Persantine::SMR000058382::cid_3108 Gamma-aminobutyric acid receptor subunit alpha-1 87.9 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23620&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search H9F 7DMC 3108 50091881 4653 CHEMBL932 DB00975 4807 ZINC00643046 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175653 OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 IZEKFCXSFNUWAM-UHFFFAOYSA-N 23620 2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol::CHEMBL932::Dipyridamine::Dipyridamole::Dipyudamine::MLS000028420::Persantine::SMR000058382::cid_3108 Gamma-aminobutyric acid receptor subunit alpha-1 162 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23620&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search H9F 7DMC 3108 50091881 4653 CHEMBL932 DB00975 4807 ZINC00643046 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175654 CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3 PPTYJKAXVCCBDU-UHFFFAOYSA-N 25878 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL13280::Flunitrazepam::[3H]Rohypnol::[3H]flunitrazepam Gamma-aminobutyric acid receptor subunit alpha-1 14.9 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25878&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3380 56413166 CHEMBL13280 DB01544 4193 ZINC03812994 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175655 CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3 PPTYJKAXVCCBDU-UHFFFAOYSA-N 25878 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL13280::Flunitrazepam::[3H]Rohypnol::[3H]flunitrazepam Gamma-aminobutyric acid receptor subunit alpha-1 40.4 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25878&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3380 56413166 CHEMBL13280 DB01544 4193 ZINC03812994 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175656 CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3 PPTYJKAXVCCBDU-UHFFFAOYSA-N 25878 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL13280::Flunitrazepam::[3H]Rohypnol::[3H]flunitrazepam Gamma-aminobutyric acid receptor subunit alpha-1 3136 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25878&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3380 56413166 CHEMBL13280 DB01544 4193 ZINC03812994 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175657 CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3 PPTYJKAXVCCBDU-UHFFFAOYSA-N 25878 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL13280::Flunitrazepam::[3H]Rohypnol::[3H]flunitrazepam Gamma-aminobutyric acid receptor subunit alpha-1 3450 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=25878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=25878&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3380 56413166 CHEMBL13280 DB01544 4193 ZINC03812994 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175658 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 1.06 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175659 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 2.04 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175660 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 2.2 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175661 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 0.54 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175662 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 1.37 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175663 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 1.41 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175664 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 1.88 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175665 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175666 CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3 RAVIZVQZGXBOQO-UHFFFAOYSA-N 22032 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide::CHEMBL15313::N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide::PK 11195::PK-11195::PK11195::RP 52028::[3H]PK 11195 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22032 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22032&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search PKA 2N02,4RYI,2MGY 1345 49845849 73290 CHEMBL15313 ZINC03870482 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175667 CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 OFBIFZUFASYYRE-UHFFFAOYSA-N 26263 Anexate::CHEMBL407::FLUMAZENIL::Ro15-1788::Romazicon::[3H]Ro15-1788::ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate Gamma-aminobutyric acid receptor subunit alpha-1 28.3 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26263&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search FYP 6D6U,6D6T,6X3U 3373 56464700 5103 CHEMBL407 DB01205 4367 C07825 ZINC00001464 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175668 CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 OFBIFZUFASYYRE-UHFFFAOYSA-N 26263 Anexate::CHEMBL407::FLUMAZENIL::Ro15-1788::Romazicon::[3H]Ro15-1788::ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate Gamma-aminobutyric acid receptor subunit alpha-1 0.87 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26263&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search FYP 6D6U,6D6T,6X3U 3373 56464700 5103 CHEMBL407 DB01205 4367 C07825 ZINC00001464 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175669 CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 OFBIFZUFASYYRE-UHFFFAOYSA-N 26263 Anexate::CHEMBL407::FLUMAZENIL::Ro15-1788::Romazicon::[3H]Ro15-1788::ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate Gamma-aminobutyric acid receptor subunit alpha-1 13.9 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26263&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search FYP 6D6U,6D6T,6X3U 3373 56464700 5103 CHEMBL407 DB01205 4367 C07825 ZINC00001464 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175670 CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 OFBIFZUFASYYRE-UHFFFAOYSA-N 26263 Anexate::CHEMBL407::FLUMAZENIL::Ro15-1788::Romazicon::[3H]Ro15-1788::ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate Gamma-aminobutyric acid receptor subunit alpha-1 24.5 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26263&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search FYP 6D6U,6D6T,6X3U 3373 56464700 5103 CHEMBL407 DB01205 4367 C07825 ZINC00001464 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175671 CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 OFBIFZUFASYYRE-UHFFFAOYSA-N 26263 Anexate::CHEMBL407::FLUMAZENIL::Ro15-1788::Romazicon::[3H]Ro15-1788::ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate Gamma-aminobutyric acid receptor subunit alpha-1 34.8 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26263&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search FYP 6D6U,6D6T,6X3U 3373 56464700 5103 CHEMBL407 DB01205 4367 C07825 ZINC00001464 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175672 CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 OFBIFZUFASYYRE-UHFFFAOYSA-N 26263 Anexate::CHEMBL407::FLUMAZENIL::Ro15-1788::Romazicon::[3H]Ro15-1788::ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate Gamma-aminobutyric acid receptor subunit alpha-1 37.4 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26263&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search FYP 6D6U,6D6T,6X3U 3373 56464700 5103 CHEMBL407 DB01205 4367 C07825 ZINC00001464 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175673 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 0.41 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175674 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 1.24 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175675 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175676 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 PUMYFTJOWAJIKF-UHFFFAOYSA-N 22040 4 -chlorodiazepam::4' Cl-diazepam::7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one::7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL286346::Ro 5-4864::Ro-05-4864::Ro-4864::Ro5-4864 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22040 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22040&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1688 49845857 CHEMBL286346 ZINC00347533 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175677 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 187 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175678 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 616 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175679 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 622 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 175680 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 767 PDSP Ki 10.1016/s0006-2952(97)00433-4 10.7270/Q2NP22ZJ 9448744 Yamagishi, H; Kawaguchi, M Tokyo Dental College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 174594 COc1cc(OC)c(cc1N[S](=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O InChI=1S/C27H31F3N4O7S/c1-40-22-16-23(41-2)20(33-42(38,39)18-8-6-17(7-9-18)27(28,29)30)15-19(22)21(35)5-3-4-12-34-13-10-26(11-14-34)24(36)31-25(37)32-26/h6-9,15-16,33H,3-5,10-14H2,1-2H3,(H2,31,32,36,37) HZZZZODVDSHQRG-UHFFFAOYSA-N 85098 N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)benzenesulfonamide::RS-102221 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0028-3908(97)00049-x 10.7270/Q2NV9GSN 9225287 Bonhaus, DW; Weinhardt, KK; Taylor, M; DeSouza, A; McNeeley, PM; Szczepanski, K; Fontana, DJ; Trinh, J; Rocha, CL; Dawson, MW; Flippin, LA; Eglen, RM Roche Bioscience http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85098&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3693566 136351198 187 ZINC26580328 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 174595 COc1cc(OC)c(cc1N[S](=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O InChI=1S/C27H31F3N4O7S/c1-40-22-16-23(41-2)20(33-42(38,39)18-8-6-17(7-9-18)27(28,29)30)15-19(22)21(35)5-3-4-12-34-13-10-26(11-14-34)24(36)31-25(37)32-26/h6-9,15-16,33H,3-5,10-14H2,1-2H3,(H2,31,32,36,37) HZZZZODVDSHQRG-UHFFFAOYSA-N 85098 N-[5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)benzenesulfonamide::RS-102221 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0028-3908(97)00049-x 10.7270/Q2NV9GSN 9225287 Bonhaus, DW; Weinhardt, KK; Taylor, M; DeSouza, A; McNeeley, PM; Szczepanski, K; Fontana, DJ; Trinh, J; Rocha, CL; Dawson, MW; Flippin, LA; Eglen, RM Roche Bioscience http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85098&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 3693566 136351198 187 ZINC26580328 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173416 CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) NTJOBXMMWNYJFB-UHFFFAOYSA-N 81790 Amisulpride::CAS_71675-85-9::NSC_2159::US10167256, Amisulpride::US10259786, Amisulpride Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81790&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2159 131342364 64045 DB06288 963 ZINC01846088 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173417 CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) NTJOBXMMWNYJFB-UHFFFAOYSA-N 81790 Amisulpride::CAS_71675-85-9::NSC_2159::US10167256, Amisulpride::US10259786, Amisulpride Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81790&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2159 131342364 64045 DB06288 963 ZINC01846088 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173418 CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 ZUXABONWMNSFBN-UHFFFAOYSA-N 22869 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene::CLOZARIL::Clozapine::Leponex::US10259786, Clozapine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22869&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2818 49846683 38 ZINC19796155 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173419 CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 ZUXABONWMNSFBN-UHFFFAOYSA-N 22869 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene::CLOZARIL::Clozapine::Leponex::US10259786, Clozapine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22869&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2818 49846683 38 ZINC19796155 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173420 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 LNEPOXFFQSENCJ-UHFFFAOYSA-N 21398 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)::4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one::CHEMBL54::CHEMBL545608::Haloperidol::Haloperidol, 1 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21398&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search GMJ 6X10,6DJZ,6LUQ 3559 49689470 5613 CHEMBL54CHEMBL545608 DB00502 86 C01814 ZINC00537822 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173421 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 LNEPOXFFQSENCJ-UHFFFAOYSA-N 21398 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)::4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one::CHEMBL54::CHEMBL545608::Haloperidol::Haloperidol, 1 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21398&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search GMJ 6X10,6DJZ,6LUQ 3559 49689470 5613 CHEMBL54CHEMBL545608 DB00502 86 C01814 ZINC00537822 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173422 CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) NTJOBXMMWNYJFB-UHFFFAOYSA-N 81790 Amisulpride::CAS_71675-85-9::NSC_2159::US10167256, Amisulpride::US10259786, Amisulpride Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81790&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2159 131342364 64045 DB06288 963 ZINC01846088 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173423 CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 ZUXABONWMNSFBN-UHFFFAOYSA-N 22869 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene::CLOZARIL::Clozapine::Leponex::US10259786, Clozapine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22869&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2818 49846683 38 ZINC19796155 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173424 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 LNEPOXFFQSENCJ-UHFFFAOYSA-N 21398 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)::4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one::CHEMBL54::CHEMBL545608::Haloperidol::Haloperidol, 1 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21398&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search GMJ 6X10,6DJZ,6LUQ 3559 49689470 5613 CHEMBL54CHEMBL545608 DB00502 86 C01814 ZINC00537822 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173425 CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) NTJOBXMMWNYJFB-UHFFFAOYSA-N 81790 Amisulpride::CAS_71675-85-9::NSC_2159::US10167256, Amisulpride::US10259786, Amisulpride Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81790&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2159 131342364 64045 DB06288 963 ZINC01846088 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173426 CN1CCN(CC1)C1=c2ccccc2=Nc2ccc(Cl)cc2N1 InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,21H,8-11H2,1H3 ZUXABONWMNSFBN-UHFFFAOYSA-N 22869 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1,3(8),4,6,10,12,14-heptaene::CLOZARIL::Clozapine::Leponex::US10259786, Clozapine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22869&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2818 49846683 38 ZINC19796155 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 173427 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2 LNEPOXFFQSENCJ-UHFFFAOYSA-N 21398 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl)::4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one::CHEMBL54::CHEMBL545608::Haloperidol::Haloperidol, 1 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2NZ865X 8996185 Schoemaker, H; Claustre, Y; Fage, D; Rouquier, L; Chergui, K; Curet, O; Oblin, A; Gonon, F; Carter, C; Benavides, J; Scatton, B Synthélabo Recherche http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=21398 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=21398&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search GMJ 6X10,6DJZ,6LUQ 3559 49689470 5613 CHEMBL54CHEMBL545608 DB00502 86 C01814 ZINC00537822 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 181001 CC(=O)C1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16?,17?,18?,19?,20-,21+/m0/s1 AURFZBICLPNKBZ-SUZPBREPSA-N 50045050 1-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-ethanone::Allopregnanolone::CHEMBL435035 Gamma-aminobutyric acid receptor subunit alpha-1 17.5 PDSP Ki 10.7270/Q2251GQJ 10991999 Vanover, KE; Rosenzweig-Lipson, S; Hawkinson, JE; Lan, NC; Belluzzi, JD; Stein, L; Barrett, JE; Wood, PL; Carter, RB CoCensys Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50045050 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50045050&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 16760287 103976150 CHEMBL435035 C05480 ZINC04096776 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 181002 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](O)(CC[C@H]34)C(F)(F)F)[C@@H]1CC[C@@H]2C(=O)CO InChI=1S/C21H31F3O3/c1-19-8-6-14-13-7-9-20(27,21(22,23)24)10-12(13)2-3-15(14)16(19)4-5-17(19)18(26)11-25/h12-17,25,27H,2-11H2,1H3/t12-,13+,14-,15-,16+,17-,19+,20-/m1/s1 GNUGUWQBSPMCQI-UDIGXYHRSA-N 85683 Co 2-6749::Co-2-6749::GMA-839::WAY-141839 Gamma-aminobutyric acid receptor subunit alpha-1 200 PDSP Ki 10.7270/Q2251GQJ 10991999 Vanover, KE; Rosenzweig-Lipson, S; Hawkinson, JE; Lan, NC; Belluzzi, JD; Stein, L; Barrett, JE; Wood, PL; Carter, RB CoCensys Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85683&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9908332 136351783 ZINC03994212 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 178543 CCOC(=O)c1ncn-2c1CN(C)C(=O)c1cc(F)ccc-21 InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3 OFBIFZUFASYYRE-UHFFFAOYSA-N 26263 Anexate::CHEMBL407::FLUMAZENIL::Ro15-1788::Romazicon::[3H]Ro15-1788::ethyl 12-fluoro-8-methyl-9-oxo-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(14),3,5,10,12-pentaene-5-carboxylate Gamma-aminobutyric acid receptor subunit alpha-1 1.52 PDSP Ki 10.1074/jbc.274.19.13370 10.7270/Q2765CWZ 10224099 Renard, S; Olivier, A; Granger, P; Avenet, P; Graham, D; Sevrin, M; George, P; Besnard, F Synthélabo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26263&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search FYP 6D6U,6D6T,6X3U 3373 56464700 5103 CHEMBL407 DB01205 4367 C07825 ZINC00001464 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 178544 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 29.6 PDSP Ki 10.1074/jbc.274.19.13370 10.7270/Q2765CWZ 10224099 Renard, S; Olivier, A; Granger, P; Avenet, P; Graham, D; Sevrin, M; George, P; Besnard, F Synthélabo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 182307 Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 QQWHWWDIFGNCLV-UHFFFAOYSA-N 85806 6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL)-9H-PYRIDO[3,4B]INDOOL-1(2H)-ON::CAS_205881-86-3::SL651498 Gamma-aminobutyric acid receptor subunit alpha-1 6.8 PDSP Ki 10.7270/Q2KS6Q34 11454940 Griebel, G; Perrault, G; Simiand, J; Cohen, C; Granger, P; Decobert, M; Francon, D; Avenet, P; Depoortere, H; Tan, S; Oblin, A; Schoemaker, H; Evanno, Y; Sevrin, M; George, P; Scatton, B Sanofi Synthelabo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85806&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9908378 136351906 ZINC00602639 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 182308 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 14 PDSP Ki 10.7270/Q2KS6Q34 11454940 Griebel, G; Perrault, G; Simiand, J; Cohen, C; Granger, P; Decobert, M; Francon, D; Avenet, P; Depoortere, H; Tan, S; Oblin, A; Schoemaker, H; Evanno, Y; Sevrin, M; George, P; Scatton, B Sanofi Synthelabo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 182309 Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 QQWHWWDIFGNCLV-UHFFFAOYSA-N 85806 6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL)-9H-PYRIDO[3,4B]INDOOL-1(2H)-ON::CAS_205881-86-3::SL651498 Gamma-aminobutyric acid receptor subunit alpha-1 17 PDSP Ki 10.7270/Q2KS6Q34 11454940 Griebel, G; Perrault, G; Simiand, J; Cohen, C; Granger, P; Decobert, M; Francon, D; Avenet, P; Depoortere, H; Tan, S; Oblin, A; Schoemaker, H; Evanno, Y; Sevrin, M; George, P; Scatton, B Sanofi Synthelabo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85806&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9908378 136351906 ZINC00602639 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 181209 Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1 InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28) RQCXKDWOCUJWQZ-UHFFFAOYSA-N 50094703 5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine::5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine::ABT-702::CHEMBL66089 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2DF6PSP 11082453 Jarvis, MF; Yu, H; Kohlhaas, K; Alexander, K; Lee, CH; Jiang, M; Bhagwat, SS; Williams, M; Kowaluk, EA Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094703&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1973 103992579 CHEMBL66089 5131 ZINC21288919 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 181210 Nc1ncnc2nc(cc(-c3cccc(Br)c3)c12)-c1ccc(nc1)N1CCOCC1 InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28) RQCXKDWOCUJWQZ-UHFFFAOYSA-N 50094703 5-(3-Bromo-phenyl)-7-(6-morpholin-4-yl-pyridin-3-yl)-pyrido[2,3-d]pyrimidin-4-ylamine::5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine::ABT-702::CHEMBL66089 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.7270/Q2DF6PSP 11082453 Jarvis, MF; Yu, H; Kohlhaas, K; Alexander, K; Lee, CH; Jiang, M; Bhagwat, SS; Williams, M; Kowaluk, EA Abbott Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50094703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50094703&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1973 103992579 CHEMBL66089 5131 ZINC21288919 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179334 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 25 PDSP Ki 10.7270/Q280515N 10454469 Araujo, F; Ruano, D; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179335 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 0.7 PDSP Ki 10.7270/Q280515N 10454469 Araujo, F; Ruano, D; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179336 Cc1nnc2ccc(nn12)-c1cccc(c1)C(F)(F)F InChI=1S/C13H9F3N4/c1-8-17-18-12-6-5-11(19-20(8)12)9-3-2-4-10(7-9)13(14,15)16/h2-7H,1H3 GUOQUXNJZHGPQF-UHFFFAOYSA-N 50026756 3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine::CHEMBL13662::CI-218872::CL 218872::CL218,872::v3-Methyl-6-(3-trifluoromethyl-phenyl)-[1,2,4]triazolo[4,3-b]pyridazine Gamma-aminobutyric acid receptor subunit alpha-1 0.81 PDSP Ki 10.7270/Q280515N 10454469 Araujo, F; Ruano, D; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50026756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50026756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 107950 103936340 CHEMBL13662 ZINC02568376 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179337 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 9.3 PDSP Ki 10.7270/Q280515N 10454469 Araujo, F; Ruano, D; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179338 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 5 PDSP Ki 10.7270/Q280515N 10454469 Araujo, F; Ruano, D; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179339 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 415 PDSP Ki 10.7270/Q280515N 10454469 Araujo, F; Ruano, D; Vitorica, J Universidad de Sevilla http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179360 Cc1ccc2oc(cc(=O)c2c1)-c1cccc(Br)c1 InChI=1S/C16H11BrO2/c1-10-5-6-15-13(7-10)14(18)9-16(19-15)11-3-2-4-12(17)8-11/h2-9H,1H3 NGKYRJKVRCEDNG-UHFFFAOYSA-N 50118406 2-(3-Bromo-phenyl)-6-methyl-chromen-4-one::6-Methyl-3'-bromoflavone::6-Methyl-3-bromoflavone::CHEMBL334427 Gamma-aminobutyric acid receptor subunit alpha-1 13.3 PDSP Ki 10.1006/bbrc.1999.1273 10.7270/Q2VT1QMS 10471378 Viola, H; Marder, M; Nunez, J; Izquierdo, L; Wasowski, C; Wolfman, C; Ardenghi, P; Barros, D; Medina, JH; Paladini, AC Instituto de Biología Celular http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118406&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 776059 104011724 CHEMBL334427 ZINC00265292 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179361 Cc1ccc2oc(cc(=O)c2c1)-c1cccc(Br)c1 InChI=1S/C16H11BrO2/c1-10-5-6-15-13(7-10)14(18)9-16(19-15)11-3-2-4-12(17)8-11/h2-9H,1H3 NGKYRJKVRCEDNG-UHFFFAOYSA-N 50118406 2-(3-Bromo-phenyl)-6-methyl-chromen-4-one::6-Methyl-3'-bromoflavone::6-Methyl-3-bromoflavone::CHEMBL334427 Gamma-aminobutyric acid receptor subunit alpha-1 18.5 PDSP Ki 10.1006/bbrc.1999.1273 10.7270/Q2VT1QMS 10471378 Viola, H; Marder, M; Nunez, J; Izquierdo, L; Wasowski, C; Wolfman, C; Ardenghi, P; Barros, D; Medina, JH; Paladini, AC Instituto de Biología Celular http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118406&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 776059 104011724 CHEMBL334427 ZINC00265292 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179362 Cc1ccc2oc(cc(=O)c2c1)-c1cccc(Br)c1 InChI=1S/C16H11BrO2/c1-10-5-6-15-13(7-10)14(18)9-16(19-15)11-3-2-4-12(17)8-11/h2-9H,1H3 NGKYRJKVRCEDNG-UHFFFAOYSA-N 50118406 2-(3-Bromo-phenyl)-6-methyl-chromen-4-one::6-Methyl-3'-bromoflavone::6-Methyl-3-bromoflavone::CHEMBL334427 Gamma-aminobutyric acid receptor subunit alpha-1 14.1 PDSP Ki 10.1006/bbrc.1999.1273 10.7270/Q2VT1QMS 10471378 Viola, H; Marder, M; Nunez, J; Izquierdo, L; Wasowski, C; Wolfman, C; Ardenghi, P; Barros, D; Medina, JH; Paladini, AC Instituto de Biología Celular http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118406&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 776059 104011724 CHEMBL334427 ZINC00265292 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 179363 Cc1ccc2oc(cc(=O)c2c1)-c1cccc(Br)c1 InChI=1S/C16H11BrO2/c1-10-5-6-15-13(7-10)14(18)9-16(19-15)11-3-2-4-12(17)8-11/h2-9H,1H3 NGKYRJKVRCEDNG-UHFFFAOYSA-N 50118406 2-(3-Bromo-phenyl)-6-methyl-chromen-4-one::6-Methyl-3'-bromoflavone::6-Methyl-3-bromoflavone::CHEMBL334427 Gamma-aminobutyric acid receptor subunit alpha-1 51 PDSP Ki 10.1006/bbrc.1999.1273 10.7270/Q2VT1QMS 10471378 Viola, H; Marder, M; Nunez, J; Izquierdo, L; Wasowski, C; Wolfman, C; Ardenghi, P; Barros, D; Medina, JH; Paladini, AC Instituto de Biología Celular http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50118406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50118406&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 776059 104011724 CHEMBL334427 ZINC00265292 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 184745 CNCCC(Oc1ccccc1C)c1ccccc1 InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3 VHGCDTVCOLNTBX-UHFFFAOYSA-N 50022784 (R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine::ATOMOXETINE::CHEMBL641::Methyl-((R)-3-phenyl-3-o-tolyloxy-propyl)-amine::Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine::Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxetine)::Strattera::Tomoxetine Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1016/S0893-133X(02)00346-9 10.7270/Q2GQ6W98 12431845 Bymaster, FP; Katner, JS; Nelson, DL; Hemrick-Luecke, SK; Threlkeld, PG; Heiligenstein, JH; Morin, SM; Gehlert, DR; Perry, KW Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50022784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50022784&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6850813 103933341 CHEMBL641 ZINC02570822 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 184838 CC(CN(C)C)CN1c2ccccc2Sc2ccc(cc12)C#N InChI=1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3 SLFGIOIONGJGRT-UHFFFAOYSA-N 86057 CAS_62865::Cyamemazine::NSC_62865 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1016/s0006-2952(02)01515-0 10.7270/Q2Q81BMG 12527336 Hameg, A; Bayle, F; Nuss, P; Dupuis, P; Garay, RP; Dib, M Aventis Pharma http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86057 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86057&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 62865 136352157 DB09000 84 ZINC05320256 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186045 NC(CCS(O)(=O)=O)C(O)=O InChI=1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10) VBOQYPQEPHKASR-UHFFFAOYSA-N 50164447 2-amino-4-sulfobutanoic acid::CHEMBL191727::DL-homocysteic acid Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164447&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search HJT 6Q6J 92117 104050228 CHEMBL191727 C15521 ZINC02567965 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186046 NC(CSSCC(N)C(O)=O)C(O)=O InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12) LEVWYRKDKASIDU-UHFFFAOYSA-N 86199 CAS_595::CAS_67678::D-cystine::L-cystine::NSC_595::NSC_67678 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86199&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search IYY 8DKM,7ZKW 595 136352299 17376 C01420 ZINC01532673 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186047 N[C@H](CCS(O)(=O)=O)C(O)=O InChI=1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m1/s1 VBOQYPQEPHKASR-GSVOUGTGSA-N 86196 D-homocysteic acid Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86196&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 185861 136352296 C15521 ZINC02545126 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186048 N[C@H](CCS(O)=O)C(O)=O InChI=1S/C4H9NO4S/c5-3(4(6)7)1-2-10(8)9/h3H,1-2,5H2,(H,6,7)(H,8,9)/t3-/m1/s1 PDNJLMZEGXHSCU-GSVOUGTGSA-N 86197 D-homocysteine sulfinic acid Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86197&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 23844143 136352297 C01615 ZINC25720437 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186049 N[C@@H]1CCSC1=O InChI=1S/C4H7NOS/c5-3-1-2-7-4(3)6/h3H,1-2,5H2/t3-/m1/s1 KIWQWJKWBHZMDT-GSVOUGTGSA-N 86205 D-homocysteine thiolactone Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86205&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7057932 136352305 ZINC54009854 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186050 CSCCC(N)C(O)=O InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8) FFEARJCKVFRZRR-UHFFFAOYSA-N 86195 CAS_6137::CAS_84815::D-methionine::L-methionine::NSC_6137::NSC_84815 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86195&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search MED 4GLS,4GLU,1Y9Q,1ZUE,5CGO,5CGN,1TKJ,6CNU,3TRY,7P5R,6DZX,3GP4,3TRV,8F16,6WI3,6JV7,4OIJ,4OIK,6PHQ,6PHN,6PHM,1KQ0,5I5A,5I5B,6WKB,2Q33,7UO8,5HHD,5XPK,3TJW,5I1P,5I1S,5I1O,5I1N 876 136352295 16811 C01733 ZINC01532766 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186051 NC(CCS(O)(=O)=O)C(O)=O InChI=1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10) VBOQYPQEPHKASR-UHFFFAOYSA-N 50164447 2-amino-4-sulfobutanoic acid::CHEMBL191727::DL-homocysteic acid Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50164447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50164447&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search HJT 6Q6J 92117 104050228 CHEMBL191727 C15521 ZINC02567965 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186052 NC(CCS)C(O)=O InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7) FFFHZYDWPBMWHY-UHFFFAOYSA-N 86202 CAS_778::DL-homocysteine::NSC_778 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86202&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search HCS 4YGW,3BOF,4HPD,2N0I,3BQ5,1Q8J,2LP2,4M3P,4L6H,2CI5,1U22,3BOL,3VK4,5OTT,5OTU,5OTV,5OTW,4L5Z,1JVI,6IQG,6R28,5F2Y,5WT5,4XFI,4XFA,4XF9,4XF4,1JQW,1XDJ,8BIX,4QQU,5X30,4PIZ,4PIY,5DMM,1Q8A,6VJU,6PO4,7F1V 778 136352302 17230 C05330 ZINC00895703 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186053 NC(CS(O)(=O)=O)C(O)=O InChI=1S/C3H7NO5S/c4-2(3(5)6)1-10(7,8)9/h2H,1,4H2,(H,5,6)(H,7,8,9) XVOYSCVBGLVSOL-UHFFFAOYSA-N 85473 L-Cysteic acid, 8::L-cysteic acid Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85473&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 00C 3FII 25701 136351573 21260 C15521 ZINC04228276 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186054 NC(CS)C(O)=O InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6) XUJNEKJLAYXESH-UHFFFAOYSA-N 86203 CAS_5862::L-cysteine::NSC_5862 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86203&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search BTC 1B23,1D7P,1ECX,1GKM,1GL3,1HFE,1I1A,1LI7,1MB4,1N26,1N31,1O7S,1PQU,1R4S,1R51,1RZG,1SSQ,1T3D,1V1Q,1XT8,208L,2D32,2D33,2DF3,2FUB,2G5R,2IBN,2IC1,2ICQ,2IO8,2IX7,2PAD,2V43,2WB9,2YJP,2YLN,2ZSV,3A9Y,3BM5,3C01,3ENJ,3GVD,3P47,3PZR,3Q0E,3TZ6,3V6O,4BB2,4BFE,4BFG,4BFI,4FF9,4G1P,4H7O,4HPC,4IEV,4IEW,4JH8,4JTO,4KSZ,4LMB,4NB0,4NB1,4OTZ,4OWD,4QM8,4QM9,4XF0,4XF1,4XF3,4XFG,4XFH,4YTG,4Z82,4ZU9,5B36,5DB5,5EH1,5EIG,5HCC,5HCD,5HCE,7API,8API,9API 594 136352303 15356 C00736 ZINC00895347 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186055 NC(CS(O)=O)C(O)=O InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8) ADVPTQAUNPRNPO-UHFFFAOYSA-N 86194 CAS_109::L-cysteine sulfinic acid::NSC_109 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86194 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86194&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search CSD 1EU1,6IKY,6IKT,6Z9O,5NY7,3E9Y,3H4H,6W0U,1TO9,3PHU,3VYH,3VYG,6MTG,4U8E,4Y1R,4Y1F,4G6W,5Z3D,5F8E,5F8F,5F8C,3PSZ,4QYT,1REV,1JKH,3TKK,3TKS,6Z9G,1BQ6,4AGI,6WE7,4NYO,4NYP,3WVD,3WVE,6R6U,4Z37,3FIV,3A8M,7L1P,1XW4,6PT4,3HHT,6Z8M,1FNK,6RUC,1VRU,1Z8N,7LR3,1BI5,4OMR,3H56,3QZ5,3QZ9,2QUG,6FTQ,7Z0V,2Z1D,6DXB,6DXC,6DXA,6DXD,6DX9,7PI0,6MU0,3U7M,3U7L,3U7N,3U7K,5WC4,5B6N,6B4R,1VI9,2ZPB,2ZPG,5K6R,5K6Q,5K6T,5IPG,5FZO,3QOR,7W6G,1SUC,1SUB,1SUD,1Q9U,4AY8,4AY7,7QOY,7QOU,7QOP,7QOM,2FHX,6RTP,3PG8,3QYG,3QYH,4PSS,4PST,4PSY,1TKT,2OPQ,2OPP,2OPS,2OPR,2OPL,2ZZD,7PJN,3I1H,3KI8,1WUO,4OQ4,8ET5,8ET4,2PVZ,1OBF,5V2W,5UR0,4CHL,2C47,5JSH,5JSU,3SMH,2J16,5IMF,5GK0,6RIZ,2R3Q,2R3P,2R3I,2R3K,2R3J,2R3M,2R3L,2R3O,2R3N,5INY,1LW2,1LW0,1LWC,1LWF,1LWE,4IEF,6ISQ,6G4R,5NAI,6N1A,2X1E,3HJ0,4NT8,3WEU,4R0V,4RYB,3QXE,1U9C,4ZGJ,4ZGE,4ZGD,1EKQ,1EKK,1MHW,3X26,3X25,3X24,3X20,3X28,7F87,7F8S,2HL8,3AWJ,3DLE,3DLG,1Q79,1Q78,3C5Y,3A8H,3OQP,3OQI,1DNC,1TKZ,5FQA,2BGA,2BG6,5JT1,1UGR,3SLE,4YUF,2ZCF,5VEX,5VEW,6G5M,5HWR,7AYJ,2IMZ,7U1D,7U1U,4P2G,4EKF,6ZK6,3T8E,4YKG,5NUE,5JQN,3ZJG,3ZJF,2V9S,1OBB,8ADD,6W42,1OKI,7XCF,7W8L,7W8M,4KPH,4U2C,3R66,1JLQ,1JLC,1JLB,1JLE,1JLG,4G2O,7BUR,7BUS,2ETF,7FFA,3P5U,1TL3,1TL1,5IMD,5IMZ,2BFZ,2GCU,6H2U,3L87,6TYY,3BC2,3BC3,3GEF,5SYA,5VF5,2ACT,1DIN,6BKA,1YBH,4LDK,2VYN,2VYV,1YM9,2DD5,1YSL,4OB1,4OB0,4OB3,4OB2,7CTM,1TVZ,1EP4,1UKK,7ZM9,5CPD,1RTH,1RTJ,1RT1,1RT3,1RT2,1RT5,1RT4,1RT7,1RT6,3T6S,1EE0,7STQ,3DMJ,6FXS,1JLA,1JLF,7TZZ,2HNY,2HNZ,2HND,1IRE,3SED,4GE3,5Z89,3EU7,3EUO,3EUT,3EUQ,3MI2,7ARF,3AWK,2E2M,4XLL,1YI1,1YI0,6YG4,4QIB,1TXT,3A9C,2QDY,2D5H,2D51,2D52,2RK6,4WPZ,1V5I,3NRA,7PNK,1VJE,2DPP,7JH0,3UK7,3CWM,3CWL,6UTN,2VB7,5IZD,3DOL,3DOK,2WLX,2WLR,2WL4,4AH4,1I86,3DM2,5IO0,1S1W,1S1V,1S1U,1S1T,1S1X,6VX2,6GW3,3SQZ,5SY9,5WSE,5WSD,5WSF,5H5S,7B1Y,7B1V,4GE0,4WZ0,2OJP,4M5P,5LRY,5LRX,1YHY,4QJE,3A8G,3A8L,3A8O,2D0Q,4WQ8,4WQ9,5G5H,2P0U,7B23,1R7A,1D6I,1D6H,3EA4,5UC5,7QOV,5K2O,5K3S,3H8C,5J78,2X1D,5W3V,1OEU,3SGU,2H9W,6L2D,6L2E,6L2F,5IOW,2C9H,1I88,1I89,5W8Q,6Z7R,3TB2,3LQY,2GDU,7NAY,1SOA,6IL2,6IL0,2RIL,2D3M,3IW3,7A74,7LVC,7UNZ,1W8C,4UAM,3UIO,3UIP,5C7I,4BPY,3CYF,5V5H,1Q1Y,5G5G,1DTT,1DTQ,1VGX,2CYZ,7FBQ,3IL9,4U85,2OAN,1YHZ,1I8B,2AHJ,6Z8J,1ACD,1TKX,1QMV,7T8L,5Y0S,5Y0T,1JWX,4GD7,7KJ0,1FK9,1FKP,1FKO,2G82,6I7R,6I7Q,4FLM,1QFM,2DXB,2DXC,4PIO,1UGP,1OCH,4P5P,4TTG,4RGC,2EG3,2HAI,4PTH,4PTJ,3F5V,2CZ0,2CZ7,2CZ6,4NJ3,1KLM,3EZG,1C1C,1C1B,4V2P,3OP0,4N12,6K5J,2ZPH,2ZPI,2ZPE,2ZPF,6XKH,1QLV,2NQT,1GZ8,6YCB,2D5F,1RTI,2CZ1,7C9J,4I07,4IW7,6ZA1,6C9U,5E68,4ORN,4D52,4Y0N,6B6L,2BC0,2BC2,7MKV,1C0T,1C0U,6ED0,6JFO,1VRT,6QUN,4FM4,6ESZ 109 136352294 4695 C01615 ZINC12501661 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186056 NC(CSSCC(N)C(O)=O)C(O)=O InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12) LEVWYRKDKASIDU-UHFFFAOYSA-N 86199 CAS_595::CAS_67678::D-cystine::L-cystine::NSC_595::NSC_67678 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86199&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search IYY 8DKM,7ZKW 595 136352299 17376 C01420 ZINC01532673 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186057 N[C@@H](CCS(O)(=O)=O)C(O)=O InChI=1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10)/t3-/m0/s1 VBOQYPQEPHKASR-VKHMYHEASA-N 50220147 (S)-2-amino-4-sulfobutanoic acid::CHEMBL230951::L-2-amino-4-sulfobutyric acid::L-Homocysteate::L-homocysteic acid Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50220147 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50220147&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search HJT 6Q6J 177491 104093189 CHEMBL230951 C16511 ZINC02567965 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186058 N[C@@H](CCS(O)=O)C(O)=O InChI=1S/C4H9NO4S/c5-3(4(6)7)1-2-10(8)9/h3H,1-2,5H2,(H,6,7)(H,8,9)/t3-/m0/s1 PDNJLMZEGXHSCU-VKHMYHEASA-N 86201 L-homocysteine sulfinic acid Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86201&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 75896 136352301 C01615 ZINC12953438 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186059 N[C@H]1CCSC1=O InChI=1S/C4H7NOS/c5-3-1-2-7-4(3)6/h3H,1-2,5H2/t3-/m0/s1 KIWQWJKWBHZMDT-VKHMYHEASA-N 86198 CAS_134505::L-homocysteine thiolactone::NSC_134505 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86198&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 134505 136352298 60315 ZINC54009855 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186060 CSCCC(N)C(O)=O InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8) FFEARJCKVFRZRR-UHFFFAOYSA-N 86195 CAS_6137::CAS_84815::D-methionine::L-methionine::NSC_6137::NSC_84815 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.047092 10.7270/Q2VT1QN7 12649361 Shi, Q; Savage, JE; Hufeisen, SJ; Rauser, L; Grajkowska, E; Ernsberger, P; Wroblewski, JT; Nadeau, JH; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86195&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search MED 4GLS,4GLU,1Y9Q,1ZUE,5CGO,5CGN,1TKJ,6CNU,3TRY,7P5R,6DZX,3GP4,3TRV,8F16,6WI3,6JV7,4OIJ,4OIK,6PHQ,6PHN,6PHM,1KQ0,5I5A,5I5B,6WKB,2Q33,7UO8,5HHD,5XPK,3TJW,5I1P,5I1S,5I1O,5I1N 876 136352295 16811 C01733 ZINC01532766 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183866 Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(O)c4c(cc(O)cc4=O)o3)c2o1 InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-33,35-37H QYDURWHTEIUTEI-UHFFFAOYSA-N 50129952 2-(3-(5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl)-4-hydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxy-phenyl)-chromen-4-one::Amentoflavone::CHEMBL63354::cid_5281600 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129952&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5281600 104021411 2631 CHEMBL63354 ZINC03984030 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183867 CC(C)C(=O)[C@]12C(=O)C(CC=C(C)C)C(=O)[C@@](CC=C(C)C)(C[C@H](CC=C(C)C)[C@@]1(C)CCC=C(C)C)C2=O InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-28H,12,16-17,19-21H2,1-11H3/t27-,28?,33+,34+,35+/m0/s1 GQRREYKSPJMLAW-CWRBZUMDSA-N 50242259 CHEMBL516641::HYPERFORIN Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242259&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91935559 104099004 CHEMBL516641 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183868 Cc1cc(O)c2c3c1c1c(CO)cc(O)c4c1c1c5c(c(O)cc(O)c5c4=O)c4c(O)cc(O)c(c4c31)c2=O InChI=1S/C30H16O9/c1-7-2-9(32)19-23-15(7)16-8(6-31)3-10(33)20-24(16)28-26-18(12(35)5-14(37)22(26)30(20)39)17-11(34)4-13(36)21(29(19)38)25(17)27(23)28/h2-5,31-37H,6H2,1H3 YXBUQQDFTYOHQI-UHFFFAOYSA-N 50333880 CHEMBL1614664::Hypericin::Pseudohypericin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333880&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5281751 125083982 CHEMBL1614664 C10392 ZINC03917574 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183869 OCC1OC(Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)C(O)C(O)C1O InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2 DPFYPHSPTUZJJT-UHFFFAOYSA-N 86036 CAS_5318390::CAS_97331::Hyperoside::Miquelianin::NSC_5318390::NSC_97331 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86036&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5378597 136352136 ZINC05004613 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183870 OCC1OC(O)C(Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)C(O)C1O InChI=1S/C21H20O12/c22-6-13-15(27)17(29)20(21(30)32-13)33-19-16(28)14-11(26)4-8(23)5-12(14)31-18(19)7-1-2-9(24)10(25)3-7/h1-5,13,15,17,20-25,27-30H,6H2 JDCKEYDYTNBCCS-UHFFFAOYSA-N 84979 Isoquercitrin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84979&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 57339948 136351079 ZINC86865007 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183871 OCC1OC(Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)C(O)C(O)C1O InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2 DPFYPHSPTUZJJT-UHFFFAOYSA-N 86036 CAS_5318390::CAS_97331::Hyperoside::Miquelianin::NSC_5318390::NSC_97331 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86036&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5378597 136352136 ZINC05004613 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183872 Cc1cc(O)c2c3c1c1c(CO)cc(O)c4c1c1c5c(c(O)cc(O)c5c4=O)c4c(O)cc(O)c(c4c31)c2=O InChI=1S/C30H16O9/c1-7-2-9(32)19-23-15(7)16-8(6-31)3-10(33)20-24(16)28-26-18(12(35)5-14(37)22(26)30(20)39)17-11(34)4-13(36)21(29(19)38)25(17)27(23)28/h2-5,31-37H,6H2,1H3 YXBUQQDFTYOHQI-UHFFFAOYSA-N 50333880 CHEMBL1614664::Hypericin::Pseudohypericin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333880&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5281751 125083982 CHEMBL1614664 C10392 ZINC03917574 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183873 Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H REFJWTPEDVJJIY-UHFFFAOYSA-N 7460 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate::CHEMBL50::Quercetin::Quercetin (10)::Quercetin (21)::Quercetin (Qur)::US11021454, Compound Quercetin::US9180183, Quercetin::med.21724, Compound 4 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7460&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search QUE 3BPT,2HCK,3LJ0,4LMU,5FLI,5FLJ,3CF8,4DFU,4MRA,4WNJ,2O3P,2MS6,5AUW,3BXX,6M89,3LM5,1GP6,6AWS,6QCN,6QCD,7VUM,6B1D,2N6C,1E8W,2C9Z,5XG4,5A4V,2UXH,1H1I,2JJ2,6TTA,6IJD,3NVY 5280343 11108251 16243 CHEMBL50 DB04216 5346 C00389 ZINC03869685 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183874 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C21H20O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-18,21-24,26-29H,1H3/t7-,15-,17+,18+,21-/m0/s1 XHIUPRGKXRAZCR-HQBVPOQASA-N 84978 Quercitrin::cid_5280459 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84978&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5280459 136351078 17558 C02757 ZINC04175638 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183875 C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(O)c4c(cc(O)cc4=O)oc3-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-30,32-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-/m0/s1 HRFGZDXDXWODFE-NVPNHPEKSA-N 50217942 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside::3-Rhamnoglucosylquercetin::3-Rutinosyl quercetin::CHEMBL226335::cid_5280805::rutin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50217942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50217942&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search RUT 1RY8 5280805 104091802 28527 CHEMBL226335 C02757 ZINC04096846 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183876 Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(O)c4c(cc(O)cc4=O)o3)c2o1 InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-33,35-37H QYDURWHTEIUTEI-UHFFFAOYSA-N 50129952 2-(3-(5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl)-4-hydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one::8-[5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxy-phenyl]-5,7-dihydroxy-2-(4-hydroxy-phenyl)-chromen-4-one::Amentoflavone::CHEMBL63354::cid_5281600 Gamma-aminobutyric acid receptor subunit alpha-1 6.17 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50129952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50129952&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5281600 104021411 2631 CHEMBL63354 ZINC03984030 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183877 CC(C)C(=O)[C@]12C(=O)C(CC=C(C)C)C(=O)[C@@](CC=C(C)C)(C[C@H](CC=C(C)C)[C@@]1(C)CCC=C(C)C)C2=O InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-28H,12,16-17,19-21H2,1-11H3/t27-,28?,33+,34+,35+/m0/s1 GQRREYKSPJMLAW-CWRBZUMDSA-N 50242259 CHEMBL516641::HYPERFORIN Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50242259 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50242259&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 91935559 104099004 CHEMBL516641 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183878 Cc1cc(O)c2c3c1c1c(CO)cc(O)c4c1c1c5c(c(O)cc(O)c5c4=O)c4c(O)cc(O)c(c4c31)c2=O InChI=1S/C30H16O9/c1-7-2-9(32)19-23-15(7)16-8(6-31)3-10(33)20-24(16)28-26-18(12(35)5-14(37)22(26)30(20)39)17-11(34)4-13(36)21(29(19)38)25(17)27(23)28/h2-5,31-37H,6H2,1H3 YXBUQQDFTYOHQI-UHFFFAOYSA-N 50333880 CHEMBL1614664::Hypericin::Pseudohypericin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333880&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5281751 125083982 CHEMBL1614664 C10392 ZINC03917574 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183879 OCC1OC(Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)C(O)C(O)C1O InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2 DPFYPHSPTUZJJT-UHFFFAOYSA-N 86036 CAS_5318390::CAS_97331::Hyperoside::Miquelianin::NSC_5318390::NSC_97331 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86036&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5378597 136352136 ZINC05004613 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183880 OCC1OC(O)C(Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)C(O)C1O InChI=1S/C21H20O12/c22-6-13-15(27)17(29)20(21(30)32-13)33-19-16(28)14-11(26)4-8(23)5-12(14)31-18(19)7-1-2-9(24)10(25)3-7/h1-5,13,15,17,20-25,27-30H,6H2 JDCKEYDYTNBCCS-UHFFFAOYSA-N 84979 Isoquercitrin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84979&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 57339948 136351079 ZINC86865007 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183881 OCC1OC(Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)C(O)C(O)C1O InChI=1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-25,27-30H,6H2 DPFYPHSPTUZJJT-UHFFFAOYSA-N 86036 CAS_5318390::CAS_97331::Hyperoside::Miquelianin::NSC_5318390::NSC_97331 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86036 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86036&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5378597 136352136 ZINC05004613 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183882 Cc1cc(O)c2c3c1c1c(CO)cc(O)c4c1c1c5c(c(O)cc(O)c5c4=O)c4c(O)cc(O)c(c4c31)c2=O InChI=1S/C30H16O9/c1-7-2-9(32)19-23-15(7)16-8(6-31)3-10(33)20-24(16)28-26-18(12(35)5-14(37)22(26)30(20)39)17-11(34)4-13(36)21(29(19)38)25(17)27(23)28/h2-5,31-37H,6H2,1H3 YXBUQQDFTYOHQI-UHFFFAOYSA-N 50333880 CHEMBL1614664::Hypericin::Pseudohypericin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50333880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50333880&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5281751 125083982 CHEMBL1614664 C10392 ZINC03917574 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183883 Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H REFJWTPEDVJJIY-UHFFFAOYSA-N 7460 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one::2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone;hydrate::CHEMBL50::Quercetin::Quercetin (10)::Quercetin (21)::Quercetin (Qur)::US11021454, Compound Quercetin::US9180183, Quercetin::med.21724, Compound 4 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7460&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search QUE 3BPT,2HCK,3LJ0,4LMU,5FLI,5FLJ,3CF8,4DFU,4MRA,4WNJ,2O3P,2MS6,5AUW,3BXX,6M89,3LM5,1GP6,6AWS,6QCN,6QCD,7VUM,6B1D,2N6C,1E8W,2C9Z,5XG4,5A4V,2UXH,1H1I,2JJ2,6TTA,6IJD,3NVY 5280343 11108251 16243 CHEMBL50 DB04216 5346 C00389 ZINC03869685 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183884 C[C@@H]1O[C@@H](Oc2c(O)c3c(cc(O)cc3=O)oc2-c2ccc(O)c(O)c2)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C21H20O11/c1-7-15(26)17(28)18(29)21(30-7)32-20-16(27)14-12(25)5-9(22)6-13(14)31-19(20)8-2-3-10(23)11(24)4-8/h2-7,15,17-18,21-24,26-29H,1H3/t7-,15-,17+,18+,21-/m0/s1 XHIUPRGKXRAZCR-HQBVPOQASA-N 84978 Quercitrin::cid_5280459 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84978&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5280459 136351078 17558 C02757 ZINC04175638 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 183885 C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(O)c4c(cc(O)cc4=O)oc3-c3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-30,32-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-/m0/s1 HRFGZDXDXWODFE-NVPNHPEKSA-N 50217942 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside::3-Rhamnoglucosylquercetin::3-Rutinosyl quercetin::CHEMBL226335::cid_5280805::rutin Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-002-1073-7 10.7270/Q25D8QDD 12110997 Butterweck, V; Nahrstedt, A; Evans, J; Hufeisen, S; Rauser, L; Savage, J; Popadak, B; Ernsberger, P; Roth, BL Westfälische Wilhelms-Universitä Muenster, http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50217942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50217942&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search RUT 1RY8 5280805 104091802 28527 CHEMBL226335 C02757 ZINC04096846 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 182673 CNCC[C@H](Oc1cccc2ccccc12)c1cccs1 InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 84745 CAS_136434-34-9::DULOXETINE::LY-248686::LY248686::USRE49340, Rank 5 Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1016/S0893-133X(01)00298-6 10.7270/Q25M648W 11750180 Bymaster, FP; Dreshfield-Ahmad, LJ; Threlkeld, PG; Shaw, JL; Thompson, L; Nelson, DL; Hemrick-Luecke, SK; Wong, DT Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=84745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=84745&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 29E 4MMD,4MM6,6M38 60835 136350845 36808 DB00476 ZINC01536779 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 182674 COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1 InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 PNVNVHUZROJLTJ-UHFFFAOYSA-N 82071 CAS_93413-69-5::CAS_99300-78-4::NSC_62923::VENLAFAXINE::Venlafaxine hydrochloride::WY-45030::WY-45655 Gamma-aminobutyric acid receptor subunit alpha-1 1000 PDSP Ki 10.1016/S0893-133X(01)00298-6 10.7270/Q25M648W 11750180 Bymaster, FP; Dreshfield-Ahmad, LJ; Threlkeld, PG; Shaw, JL; Thompson, L; Nelson, DL; Hemrick-Luecke, SK; Wong, DT Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82071 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82071&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search VFX 8F4W 5656 131342645 DB00285 C07187 ZINC00896698 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186417 CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26) ROGUAPYLUCHQGK-UHFFFAOYSA-N 50133817 4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide::BCTC::CHEMBL441472::N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.045674 10.7270/Q2TX3CX5 12721338 Valenzano, KJ; Grant, ER; Wu, G; Hachicha, M; Schmid, L; Tafesse, L; Sun, Q; Rotshteyn, Y; Francis, J; Limberis, J; Malik, S; Whittemore, ER; Hodges, D Pudue Pharma Discovery Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50133817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50133817&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9929425 104024571 CHEMBL441472 2460 ZINC27109670 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186418 CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26) ROGUAPYLUCHQGK-UHFFFAOYSA-N 50133817 4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic acid (4-tert-butyl-phenyl)-amide::BCTC::CHEMBL441472::N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)piperazine-1-carboxamide Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.102.045674 10.7270/Q2TX3CX5 12721338 Valenzano, KJ; Grant, ER; Wu, G; Hachicha, M; Schmid, L; Tafesse, L; Sun, Q; Rotshteyn, Y; Francis, J; Limberis, J; Malik, S; Whittemore, ER; Hodges, D Pudue Pharma Discovery Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50133817 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50133817&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9929425 104024571 CHEMBL441472 2460 ZINC27109670 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 184110 COC(=O)[C@@H]1C[C@H](OC(C)=O)C(=O)[C@H]2[C@@]1(C)CC[C@H]1C(=O)O[C@@H](C[C@]21C)c1ccoc1 InChI=1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1 OBSYBRPAKCASQB-AGQYDFLVSA-N 50159165 (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(furan-3-yl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester::(2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-(acetylthio)-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-dodecahydro-1H-benzo[f]isochromene-7-carboxylate::(2S,4aR,6aR,7R,9S,10aS,10bR)-methyl 9-acetoxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-dodecahydro-1H-benzo[f]isochromene-7-carboxylate::(3S,4aR,4bS,6S,8R,8aR,10aR)-6-Acetoxy-3-furan-3-yl-4a,8a-dimethyl-1,5-dioxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester::2S,4aR,6a(R,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(furan-3-yl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester::CHEMBL445332::Salvinorin A::Salvonorin A::salvinorin-A Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1073/pnas.182234399 10.7270/Q2CZ35Q9 12192085 Roth, BL; Baner, K; Westkaemper, R; Siebert, D; Rice, KC; Steinberg, S; Ernsberger, P; Rothman, RB Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50159165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50159165&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 128563 104045748 67900 CHEMBL445332 1666 ZINC13607514 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186557 CNC(C)Cc1ccc2OCOc2c1 InChI=1S/C11H15NO2/c1-8(12-2)5-9-3-4-10-11(6-9)14-7-13-10/h3-4,6,8,12H,5,7H2,1-2H3 SHXWCVYOXRDMCX-UHFFFAOYSA-N 50010588 (RS)-3,4-(methylenedioxy)methamphetamine::1-(1,3-Benzodioxol-5-yl)-N-methyl-2-propanamine::1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine::3,4-methylenedioxymethamphetamine::CHEMBL43048::DL-(3,4-Methylenedioxy)methamphetamine::MDMA::N,alpha-dimethyl-1,3-benzodioxole-5-ethanamine::N-Methyl-3,4-methylenedioxyamphetamine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/mol.63.6.1223 10.7270/Q2FN14SJ 12761331 Setola, V; Hufeisen, SJ; Grande-Allen, KJ; Vesely, I; Glennon, RA; Blough, B; Rothman, RB; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010588&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search B41 3GM0 1615 103923364 1391 CHEMBL43048 DB01454 4574 C07577 ZINC00403053 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186558 CNC(C)Cc1ccc2OCOc2c1 InChI=1S/C11H15NO2/c1-8(12-2)5-9-3-4-10-11(6-9)14-7-13-10/h3-4,6,8,12H,5,7H2,1-2H3 SHXWCVYOXRDMCX-UHFFFAOYSA-N 50010588 (RS)-3,4-(methylenedioxy)methamphetamine::1-(1,3-Benzodioxol-5-yl)-N-methyl-2-propanamine::1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine::3,4-methylenedioxymethamphetamine::CHEMBL43048::DL-(3,4-Methylenedioxy)methamphetamine::MDMA::N,alpha-dimethyl-1,3-benzodioxole-5-ethanamine::N-Methyl-3,4-methylenedioxyamphetamine Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/mol.63.6.1223 10.7270/Q2FN14SJ 12761331 Setola, V; Hufeisen, SJ; Grande-Allen, KJ; Vesely, I; Glennon, RA; Blough, B; Rothman, RB; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010588&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search B41 3GM0 1615 103923364 1391 CHEMBL43048 DB01454 4574 C07577 ZINC00403053 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186628 Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29) CEUORZQYGODEFX-UHFFFAOYSA-N 50130293 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one::ARIPIPRAZOLE::CHEMBL1112::US10174011, aripiprazole::US10752588, Compound Aripiprazole::US11498896, Compound Aripiprazole::US9018213, aripprazole::US9156822, Aripiprazole Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1038/sj.npp.1300203 10.7270/Q2639N9T 12784105 Shapiro, DA; Renock, S; Arrington, E; Chiodo, LA; Liu, LX; Sibley, DR; Roth, BL; Mailman, R Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130293&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9SC 7VR9,7E2Z,6A7P,7VOE,7WKZ 60795 104021727 31236 CHEMBL1112 DB01238 34 C12564 ZINC01851149 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 186642 Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29) CEUORZQYGODEFX-UHFFFAOYSA-N 50130293 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one::ARIPIPRAZOLE::CHEMBL1112::US10174011, aripiprazole::US10752588, Compound Aripiprazole::US11498896, Compound Aripiprazole::US9018213, aripprazole::US9156822, Aripiprazole Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1038/sj.npp.1300203 10.7270/Q2639N9T 12784105 Shapiro, DA; Renock, S; Arrington, E; Chiodo, LA; Liu, LX; Sibley, DR; Roth, BL; Mailman, R Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50130293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50130293&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9SC 7VR9,7E2Z,6A7P,7VOE,7WKZ 60795 104021727 31236 CHEMBL1112 DB01238 34 C12564 ZINC01851149 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188888 ONC=Nc1ccc(N2CCOCC2)c(Cl)c1 InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14) ZTXADXBIGLLOFX-UHFFFAOYSA-N 86694 N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyformamidine::TS-011 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1124/jpet.105.083964 10.7270/Q2MW2FQQ 15831442 Miyata, N; Seki, T; Tanaka, Y; Omura, T; Taniguchi, K; Doi, M; Bandou, K; Kametani, S; Sato, M; Okuyama, S; Cambj-Sapunar, L; Harder, DR; Roman, RJ Taisho Pharmaceutical Co., Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86694 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86694&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9816527 136352743 ZINC06746071 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 190331 CCN1CCCC1CNC(=O)c1cc(c(N)cc1OC)S(=O)(=O)CC InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) NTJOBXMMWNYJFB-UHFFFAOYSA-N 81790 Amisulpride::CAS_71675-85-9::NSC_2159::US10167256, Amisulpride::US10259786, Amisulpride Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-009-1521-8 10.7270/Q2TB15G7 19337725 Abbas, AI; Hedlund, PB; Huang, XP; Tran, TB; Meltzer, HY; Roth, BL Case Western Reserve University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81790&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2159 131342364 64045 DB06288 963 ZINC01846088 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188098 CN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C(=O)c1cccs1 InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3 CBIAWPMZSFFRGN-UHFFFAOYSA-N 86522 CAS_325715-02-4::Indiplon Gamma-aminobutyric acid receptor subunit alpha-1 1.2 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86522&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6450813 136352571 4221 ZINC00538650 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188099 CN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C(=O)c1cccs1 InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3 CBIAWPMZSFFRGN-UHFFFAOYSA-N 86522 CAS_325715-02-4::Indiplon Gamma-aminobutyric acid receptor subunit alpha-1 1.8 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86522&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6450813 136352571 4221 ZINC00538650 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188100 CN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C(=O)c1cccs1 InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3 CBIAWPMZSFFRGN-UHFFFAOYSA-N 86522 CAS_325715-02-4::Indiplon Gamma-aminobutyric acid receptor subunit alpha-1 1.2 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86522&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6450813 136352571 4221 ZINC00538650 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188101 Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12 InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 JOFWLTCLBGQGBO-UHFFFAOYSA-N 50001765 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::CHEMBL646::Halcion::TRIAZOLAM Gamma-aminobutyric acid receptor subunit alpha-1 0.34 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001765&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5556 103916143 9674 CHEMBL646 DB00897 7313 ZINC00002212 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188102 Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12 InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 JOFWLTCLBGQGBO-UHFFFAOYSA-N 50001765 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::CHEMBL646::Halcion::TRIAZOLAM Gamma-aminobutyric acid receptor subunit alpha-1 0.31 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001765&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5556 103916143 9674 CHEMBL646 DB00897 7313 ZINC00002212 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188103 Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12 InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 JOFWLTCLBGQGBO-UHFFFAOYSA-N 50001765 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::CHEMBL646::Halcion::TRIAZOLAM Gamma-aminobutyric acid receptor subunit alpha-1 0.55 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001765&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5556 103916143 9674 CHEMBL646 DB00897 7313 ZINC00002212 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188104 Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12 InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 JOFWLTCLBGQGBO-UHFFFAOYSA-N 50001765 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::CHEMBL646::Halcion::TRIAZOLAM Gamma-aminobutyric acid receptor subunit alpha-1 0.45 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50001765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50001765&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5556 103916143 9674 CHEMBL646 DB00897 7313 ZINC00002212 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188105 CCN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C#N InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3 HUNXMJYCHXQEGX-UHFFFAOYSA-N 86521 CAS_5719::NSC_5719::Zaleplon Gamma-aminobutyric acid receptor subunit alpha-1 81.2 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86521&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5719 136352570 10102 DB00962 C07484 ZINC00006300 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188106 CCN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C#N InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3 HUNXMJYCHXQEGX-UHFFFAOYSA-N 86521 CAS_5719::NSC_5719::Zaleplon Gamma-aminobutyric acid receptor subunit alpha-1 59.8 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86521&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5719 136352570 10102 DB00962 C07484 ZINC00006300 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188107 CCN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C#N InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3 HUNXMJYCHXQEGX-UHFFFAOYSA-N 86521 CAS_5719::NSC_5719::Zaleplon Gamma-aminobutyric acid receptor subunit alpha-1 68.5 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86521&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5719 136352570 10102 DB00962 C07484 ZINC00006300 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188108 CCN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C#N InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3 HUNXMJYCHXQEGX-UHFFFAOYSA-N 86521 CAS_5719::NSC_5719::Zaleplon Gamma-aminobutyric acid receptor subunit alpha-1 45.5 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86521&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5719 136352570 10102 DB00962 C07484 ZINC00006300 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188109 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 12.6 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188110 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 13.5 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188111 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 11.2 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 188112 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 10.3 PDSP Ki 10.1124/jpet.104.071282 10.7270/Q2VH5MD8 15256540 Sullivan, SK; Petroski, RE; Verge, G; Gross, RS; Foster, AC; Grigoriadis, DE Neurocrine Biosciences Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 189579 COc1ccccc1N1CCN(CCN(C(=O)C2CCCCC2)c2ccccn2)CC1 InChI=1S/C25H34N4O2/c1-31-23-12-6-5-11-22(23)28-18-15-27(16-19-28)17-20-29(24-13-7-8-14-26-24)25(30)21-9-3-2-4-10-21/h5-8,11-14,21H,2-4,9-10,15-20H2,1H3 SBPRIAGPYFYCRT-UHFFFAOYSA-N 86708 CAS_146714-97-8::CHEMBL31354::CHEMBL514874::CHEMBL537403::NSC_104911::WAY 100,635 Gamma-aminobutyric acid receptor subunit alpha-1 >10000 PDSP Ki 10.1007/s00213-006-0490-4 10.7270/Q2HX1B8P 16915381 Chemel, BR; Roth, BL; Armbruster, B; Watts, VJ; Nichols, DE Purdue University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86708 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86708&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 5684 136352757 CHEMBL537403CHEMBL514874CHEMBL31354 ZINC52541473 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50424938 Sc1nnc(o1)C1CCNCC1 InChI=1S/C7H11N3OS/c12-7-10-9-6(11-7)5-1-3-8-4-2-5/h5,8H,1-4H2,(H,10,12) VALHDAVLBCMZCU-UHFFFAOYSA-N 50273004 5-Piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione Hydrochloride::CHEMBL456576 Gamma-aminobutyric acid receptor subunit alpha-1 9500000 ChEMBL 10.1021/jm701562x 10.7270/Q2FF3S6G 18651727 Jansen, M; Rabe, H; Strehle, A; Dieler, S; Debus, F; Dannhardt, G; Akabas, MH; Luddens, H Johannes Gutenberg University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273004&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24950204 104117252 CHEMBL456576 ZINC40848977 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50424939 Sc1nnc(o1)C1CCNCC1 InChI=1S/C7H11N3OS/c12-7-10-9-6(11-7)5-1-3-8-4-2-5/h5,8H,1-4H2,(H,10,12) VALHDAVLBCMZCU-UHFFFAOYSA-N 50273004 5-Piperidin-4-yl-3H-[1,3,4]oxadiazol-2-thione Hydrochloride::CHEMBL456576 Gamma-aminobutyric acid receptor subunit alpha-1 59000 ChEMBL 10.1021/jm701562x 10.7270/Q2FF3S6G 18651727 Jansen, M; Rabe, H; Strehle, A; Dieler, S; Debus, F; Dannhardt, G; Akabas, MH; Luddens, H Johannes Gutenberg University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273004 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273004&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24950204 104117252 CHEMBL456576 ZINC40848977 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50424940 NCCCC(O)=O InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7) BTCSSZJGUNDROE-UHFFFAOYSA-N 24183 4-amino-n-[2,3-3H]butyric acid::4-aminobutanoic acid::Aminalon::CHEMBL96::GABA::Gamma-Aminobutyric acid::[3H]GABA::cid_119 Gamma-aminobutyric acid receptor subunit alpha-1 10000 ChEMBL 10.1021/jm701562x 10.7270/Q2FF3S6G 18651727 Jansen, M; Rabe, H; Strehle, A; Dieler, S; Debus, F; Dannhardt, G; Akabas, MH; Luddens, H Johannes Gutenberg University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=24183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=24183&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search ABU 5LTV,2YOE,1M19,6SSI,1QUR,7OPM,6JDW,4M3C,4ATQ,6PLO,6PLV,4MS3,4EUO,7QNB,7QNA,6D6U,7K2O,1M1A,3IP9,6EB3,4K17,7PBZ,6HUO,6HUP,7PBD,6A96,8DD2,8DD3,4RLG,6D6T,7Y7W,6DW1,6DW0,1S32,6X3W,6X3V,6X3U,6X3T,6X3Z,6X3X,5T4J,2JT9,4PCR,2OKJ,2OKK,7QN7,3V5A,6HUJ,5OE1,6DN6,5LRV,3USU,7T0Z,6PLZ,6PLX,6PLY,6PLP,6PLQ,6PLW,6PLU,5ODM,6X40,5X03,7X4Y,4I30 119 53786180 16865 CHEMBL96 DB02530 1067 C00334 ZINC01532620 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50424941 NCc1n[nH]c(=O)o1 InChI=1S/C3H5N3O2/c4-1-2-5-6-3(7)8-2/h1,4H2,(H,6,7) BGFKDHCRDPQSGH-UHFFFAOYSA-N 50273002 5-Aminomethyl-3H-[1,3,4]oxadiazol-2-one Hydrochloride::CHEMBL454608 Gamma-aminobutyric acid receptor subunit alpha-1 280000 ChEMBL 10.1021/jm701562x 10.7270/Q2FF3S6G 18651727 Jansen, M; Rabe, H; Strehle, A; Dieler, S; Debus, F; Dannhardt, G; Akabas, MH; Luddens, H Johannes Gutenberg University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50273002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50273002&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 24950198 104117250 CHEMBL454608 ZINC40380151 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461032 Fc1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1 InChI=1S/C17H13FN2O2/c18-12-7-5-11(6-8-12)9-20-17(22)16(21)14-10-19-15-4-2-1-3-13(14)15/h1-8,10,19H,9H2,(H,20,22) VWCCHJFFYCGXFL-UHFFFAOYSA-N 50055244 CHEMBL127135::N-(4-Fluoro-benzyl)-2-(1H-indol-3-yl)-2-oxo-acetamide::N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide Gamma-aminobutyric acid receptor subunit alpha-1 245 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055244 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055244&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 2986030 103951756 CHEMBL127135 ZINC04163149 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461033 [O-][N+](=O)c1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1 InChI=1S/C17H13N3O4/c21-16(14-10-18-15-4-2-1-3-13(14)15)17(22)19-9-11-5-7-12(8-6-11)20(23)24/h1-8,10,18H,9H2,(H,19,22) SQVFGSDZEHNBTN-UHFFFAOYSA-N 50101429 2-(1H-Indol-3-yl)-N-(4-nitro-benzyl)-2-oxo-acetamide::2-(1H-indol-3-yl)-N-(4-nitrobenzyl)-2-oxoacetamide::CHEMBL74302 Gamma-aminobutyric acid receptor subunit alpha-1 16 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101429 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101429&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 11045532 103998094 CHEMBL74302 ZINC13863208 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461034 [O-][N+](=O)c1ccc(CNC(=O)C(=O)c2c[nH]c3ccc(cc23)[N+]([O-])=O)cc1 InChI=1S/C17H12N4O6/c22-16(14-9-18-15-6-5-12(21(26)27)7-13(14)15)17(23)19-8-10-1-3-11(4-2-10)20(24)25/h1-7,9,18H,8H2,(H,19,23) WONGJCVMNCAMKQ-UHFFFAOYSA-N 50101423 2-(5-nitro-1H-indol-3-yl)-N-(4-nitrobenzyl)-2-oxoacetamide::CHEMBL307139::N-(4-Nitro-benzyl)-2-(5-nitro-1H-indol-3-yl)-2-oxo-acetamide Gamma-aminobutyric acid receptor subunit alpha-1 293 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101423 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101423&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 10861519 103998088 CHEMBL307139 ZINC13863210 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461035 COc1ccc(CNC(=O)C(=O)c2c[nH]c3ccccc23)cc1 InChI=1S/C18H16N2O3/c1-23-13-8-6-12(7-9-13)10-20-18(22)17(21)15-11-19-16-5-3-2-4-14(15)16/h2-9,11,19H,10H2,1H3,(H,20,22) STQWWORVIGBLOE-UHFFFAOYSA-N 50055265 2-(1H-Indol-3-yl)-N-(4-methoxy-benzyl)-2-oxo-acetamide::2-(1H-indol-3-yl)-N-(4-methoxybenzyl)-2-oxoacetamide::CHEMBL306310 Gamma-aminobutyric acid receptor subunit alpha-1 195 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055265 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055265&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1588018 103951777 CHEMBL306310 ZINC01803423 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461036 COc1ccc(CNC(=O)C(=O)c2c[nH]c3ccc(cc23)[N+]([O-])=O)cc1 InChI=1S/C18H15N3O5/c1-26-13-5-2-11(3-6-13)9-20-18(23)17(22)15-10-19-16-7-4-12(21(24)25)8-14(15)16/h2-8,10,19H,9H2,1H3,(H,20,23) SNEWVMXJSABDSK-UHFFFAOYSA-N 50055247 CHEMBL75306::N-(4-Methoxy-benzyl)-2-(5-nitro-1H-indol-3-yl)-2-oxo-acetamide::N-(4-methoxybenzyl)-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide Gamma-aminobutyric acid receptor subunit alpha-1 42 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50055247 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50055247&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 10665748 103951759 CHEMBL75306 ZINC13760651 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461037 C[C@@H](NC(=O)C(=O)c1c[nH]c2ccccc12)c1ccccc1 InChI=1S/C18H16N2O2/c1-12(13-7-3-2-4-8-13)20-18(22)17(21)15-11-19-16-10-6-5-9-14(15)16/h2-12,19H,1H3,(H,20,22)/t12-/m1/s1 JCQKMELKMGOGMR-GFCCVEGCSA-N 50101422 (R)-2-(1H-indol-3-yl)-2-oxo-N-(1-phenylethyl)acetamide::2-(1H-Indol-3-yl)-2-oxo-N-(1-phenyl-ethyl)-acetamide::CHEMBL75406 Gamma-aminobutyric acid receptor subunit alpha-1 1150 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101422 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101422&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 7117331 103998087 CHEMBL75406 ZINC04163163 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461038 C[C@@H](NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1ccccc1 InChI=1S/C18H15N3O4/c1-11(12-5-3-2-4-6-12)20-18(23)17(22)15-10-19-16-8-7-13(21(24)25)9-14(15)16/h2-11,19H,1H3,(H,20,23)/t11-/m1/s1 VCKKJKQZHHPPDR-LLVKDONJSA-N 50101427 (R)-2-(5-nitro-1H-indol-3-yl)-2-oxo-N-(1-phenylethyl)acetamide::2-(5-Nitro-1H-indol-3-yl)-2-oxo-N-(1-phenyl-ethyl)-acetamide::CHEMBL75456 Gamma-aminobutyric acid receptor subunit alpha-1 14 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50101427 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50101427&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 10315001 103998092 CHEMBL75456 ZINC13863224 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461039 O=C(N[C@@H]1CCc2ccccc12)C(=O)c1c[nH]c2ccccc12 InChI=1S/C19H16N2O2/c22-18(15-11-20-16-8-4-3-7-14(15)16)19(23)21-17-10-9-12-5-1-2-6-13(12)17/h1-8,11,17,20H,9-10H2,(H,21,23)/t17-/m1/s1 HPOOEGNMALNZJV-QGZVFWFLSA-N 50268744 (R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(1H-indol-3-yl)-2-oxoacetamide::CHEMBL495592 Gamma-aminobutyric acid receptor subunit alpha-1 225 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50268744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50268744&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 10935596 104114993 CHEMBL495592 ZINC13863234 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461040 [O-][N+](=O)c1ccc2[nH]cc(C(=O)C(=O)N[C@@H]3CCc4ccccc34)c2c1 InChI=1S/C19H15N3O4/c23-18(15-10-20-16-8-6-12(22(25)26)9-14(15)16)19(24)21-17-7-5-11-3-1-2-4-13(11)17/h1-4,6,8-10,17,20H,5,7H2,(H,21,24)/t17-/m1/s1 KFWPQIRBHBKYME-QGZVFWFLSA-N 50268784 (R)-N-(2,3-dihydro-1H-inden-1-yl)-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide::CHEMBL521901 Gamma-aminobutyric acid receptor subunit alpha-1 9 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50268784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50268784&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 10450468 104115010 CHEMBL521901 ZINC13863236 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461041 Fc1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccccc12 InChI=1S/C19H15FN2O2/c20-12-6-7-13-11(9-12)5-8-17(13)22-19(24)18(23)15-10-21-16-4-2-1-3-14(15)16/h1-4,6-7,9-10,17,21H,5,8H2,(H,22,24) FCYPCFSFYDNWLQ-UHFFFAOYSA-N 50268785 (R/S)-N-(5-fluoro-2,3-dihydro-1H-inden-1-yl)-2-(1H-indol-3-yl)-2-oxoacetamide::CHEMBL522716 Gamma-aminobutyric acid receptor subunit alpha-1 2049 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50268785 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50268785&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44157434 104115011 CHEMBL522716 ZINC40430095 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461042 [O-][N+](=O)c1ccc2[nH]cc(C(=O)C(=O)NC3CCc4cc(F)ccc34)c2c1 InChI=1S/C19H14FN3O4/c20-11-2-4-13-10(7-11)1-5-17(13)22-19(25)18(24)15-9-21-16-6-3-12(23(26)27)8-14(15)16/h2-4,6-9,17,21H,1,5H2,(H,22,25) KCTWTQNQVBDHCG-UHFFFAOYSA-N 50268786 (R/S)-N-(5-fluoro-2,3-dihydro-1H-inden-1-yl)-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide::CHEMBL495615 Gamma-aminobutyric acid receptor subunit alpha-1 195 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50268786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50268786&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44157438 104115012 CHEMBL495615 ZINC40954684 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461043 [O-][N+](=O)c1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O InChI=1S/C19H14N4O6/c24-18(15-9-20-16-6-3-12(23(28)29)8-14(15)16)19(25)21-17-5-1-10-7-11(22(26)27)2-4-13(10)17/h2-4,6-9,17,20H,1,5H2,(H,21,25) YPSCSODEMUDTBM-UHFFFAOYSA-N 50268787 (R/S)-2-(5-nitro-1H-indol-3-yl)-N-(5-nitro-2,3-dihydro-1H-inden-1-yl)-2-oxoacetamide::CHEMBL495616 Gamma-aminobutyric acid receptor subunit alpha-1 200 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50268787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50268787&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44157140 104115013 CHEMBL495616 ZINC40429960 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461044 COc1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccccc12 InChI=1S/C20H18N2O3/c1-25-13-7-8-14-12(10-13)6-9-18(14)22-20(24)19(23)16-11-21-17-5-3-2-4-15(16)17/h2-5,7-8,10-11,18,21H,6,9H2,1H3,(H,22,24) FKIFCJXVYFACJA-UHFFFAOYSA-N 50268892 (R/S)-2-(1H-indol-3-yl)-N-(5-methoxy-2,3-dihydro-1H-inden-1-yl)-2-oxoacetamide::CHEMBL495635 Gamma-aminobutyric acid receptor subunit alpha-1 246 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50268892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50268892&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44157142 104115045 CHEMBL495635 ZINC40957192 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461045 COc1ccc2C(CCc2c1)NC(=O)C(=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O InChI=1S/C20H17N3O5/c1-28-13-4-5-14-11(8-13)2-6-18(14)22-20(25)19(24)16-10-21-17-7-3-12(23(26)27)9-15(16)17/h3-5,7-10,18,21H,2,6H2,1H3,(H,22,25) VDHLHILIXOHGNF-UHFFFAOYSA-N 50268893 (R/S)-N-(5-methoxy-2,3-dihydro-1H-inden-1-yl)-2-(5-nitro-1H-indol-3-yl)-2-oxoacetamide::CHEMBL495634 Gamma-aminobutyric acid receptor subunit alpha-1 28 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50268893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50268893&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44157437 104115046 CHEMBL495634 ZINC40957186 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461046 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 11 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50461047 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 50 ChEMBL 10.1021/jm9001154 10.7270/Q2N58M89 19469479 Taliani, S; Cosimelli, B; Da Settimo, F; Marini, AM; La Motta, C; Simorini, F; Salerno, S; Novellino, E; Greco, G; Cosconati, S; Marinelli, L; Salvetti, F; L'Abbate, G; Trasciatti, S; Montali, M; Costa, B; Martini, C Universita di Pisa http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50506318 Cc1ccc2nc(cc(O)c2c1)-c1cc(Cc2ccccc2)ccc1O InChI=1S/C23H19NO2/c1-15-7-9-20-18(11-15)23(26)14-21(24-20)19-13-17(8-10-22(19)25)12-16-5-3-2-4-6-16/h2-11,13-14,25H,12H2,1H3,(H,24,26) ZTLOBJCILUZKRV-UHFFFAOYSA-N 50293262 2-(5-benzyl-2-hydroxyphenyl)-6-methylquinolin-4(1H)-one::CHEMBL502159 Gamma-aminobutyric acid receptor subunit alpha-1 1.2 ChEMBL 10.1016/j.bmcl.2008.09.092 10.7270/Q2CF9Q3Z 18851913 Nilsson, J; Nielsen, EØ; Liljefors, T; Nielsen, M; Sterner, O Lund University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50293262 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50293262&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44581039 104134813 CHEMBL502159 ZINC40833887 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50506319 Cc1ccc2oc(cc(=O)c2c1)-c1cc(Cc2ccccc2)ccc1O InChI=1S/C23H18O3/c1-15-7-10-22-18(11-15)21(25)14-23(26-22)19-13-17(8-9-20(19)24)12-16-5-3-2-4-6-16/h2-11,13-14,24H,12H2,1H3 UHHVZGAPCPFAGJ-UHFFFAOYSA-N 50293263 2-(5-benzyl-2-hydroxyphenyl)-6-methyl-4H-chromen-4-one::CHEMBL522061 Gamma-aminobutyric acid receptor subunit alpha-1 0.8 ChEMBL 10.1016/j.bmcl.2008.09.092 10.7270/Q2CF9Q3Z 18851913 Nilsson, J; Nielsen, EØ; Liljefors, T; Nielsen, M; Sterner, O Lund University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50293263 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50293263&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44581040 104134814 CHEMBL522061 ZINC40972937 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50506322 Cc1ccc2nc(cc(O)c2c1)-c1cc(Br)ccc1O InChI=1S/C16H12BrNO2/c1-9-2-4-13-11(6-9)16(20)8-14(18-13)12-7-10(17)3-5-15(12)19/h2-8,19H,1H3,(H,18,20) NYRFXWGBTPDDKD-UHFFFAOYSA-N 50293264 2-(5-bromo-2-hydroxyphenyl)-6-methylquinolin-4(1H)-one::CHEMBL452728 Gamma-aminobutyric acid receptor subunit alpha-1 39 ChEMBL 10.1016/j.bmcl.2008.09.092 10.7270/Q2CF9Q3Z 18851913 Nilsson, J; Nielsen, EØ; Liljefors, T; Nielsen, M; Sterner, O Lund University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50293264 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50293264&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 44581037 104134815 CHEMBL452728 ZINC40836639 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50833901 NCc1cc(=O)[nH]o1 InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) ZJQHPWUVQPJPQT-UHFFFAOYSA-N 23183 5-(aminomethyl)-1,2-oxazol-3-ol::Agarin::CHEMBL273481::Muscimol::Pantherine Gamma-aminobutyric acid receptor subunit alpha-1 16 ChEMBL 10.1021/jm058018d 10.7270/Q28C9X1X 16250647 Minetti, P; Tinti, MO; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Piersanti, G; Bartoccini, F; Tarzia, G Universit£ degli Studi di Urbino Carlo Bo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=23183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=23183&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 4266 49846996 CHEMBL273481 4259 C08311 ZINC22064260 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50833935 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 12 ChEMBL 10.1021/jm058018d 10.7270/Q28C9X1X 16250647 Minetti, P; Tinti, MO; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Piersanti, G; Bartoccini, F; Tarzia, G Universit£ degli Studi di Urbino Carlo Bo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50864272 CN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C(=O)c1cccs1 InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3 CBIAWPMZSFFRGN-UHFFFAOYSA-N 86522 CAS_325715-02-4::Indiplon Gamma-aminobutyric acid receptor subunit alpha-1 0.55 ChEMBL 10.1016/j.bmc.2007.10.079 10.7270/Q2QR4XZZ 18023192 Hoepping, A; Diekers, M; Deuther-Conrad, W; Scheunemann, M; Fischer, S; Hiller, A; Wegner, F; Steinbach, J; Brust, P ABX advanced biochemical compounds GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86522&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6450813 136352571 4221 ZINC00538650 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50864273 CN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C(=O)c1cccs1 InChI=1S/C20H16N4O2S/c1-13(25)23(2)15-6-3-5-14(11-15)17-8-9-21-20-16(12-22-24(17)20)19(26)18-7-4-10-27-18/h3-12H,1-2H3 CBIAWPMZSFFRGN-UHFFFAOYSA-N 86522 CAS_325715-02-4::Indiplon Gamma-aminobutyric acid receptor subunit alpha-1 0.45 ChEMBL 10.1016/j.bmc.2007.10.079 10.7270/Q2QR4XZZ 18023192 Hoepping, A; Diekers, M; Deuther-Conrad, W; Scheunemann, M; Fischer, S; Hiller, A; Wegner, F; Steinbach, J; Brust, P ABX advanced biochemical compounds GmbH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=86522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=86522&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 6450813 136352571 4221 ZINC00538650 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50684255 CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1 InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3 ZAFYATHCZYHLPB-UHFFFAOYSA-N 26266 Ambien::CHEMBL911::Dalparan::N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide::ZPM::Zolpidem::Zolpidem tartrate Gamma-aminobutyric acid receptor subunit alpha-1 27 ChEMBL 10.1016/j.ejmech.2016.11.019 10.7270/Q2S184RN 27894044 Cherukupalli, S; Karpoormath, R; Chandrasekaran, B; Hampannavar, GA; Thapliyal, N; Palakollu, VN University of KwaZulu-Natal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=26266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=26266&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search R5R 8DD2 5732 56464703 10125 CHEMBL911 DB00425 4348 C07219 ZINC00003876 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50684301 CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3 AAOVKJBEBIDNHE-UHFFFAOYSA-N 50000766 CHEMBL12::DIAZEPAM::US9271961, Diazepam Gamma-aminobutyric acid receptor subunit alpha-1 14 ChEMBL 10.1016/j.ejmech.2016.11.019 10.7270/Q2S184RN 27894044 Cherukupalli, S; Karpoormath, R; Chandrasekaran, B; Hampannavar, GA; Thapliyal, N; Palakollu, VN University of KwaZulu-Natal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search DZP 6HUP,2BXF,6X3X 3016 103915310 49575 CHEMBL12 DB00829 3364 C06948 ZINC00006427 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 50684332 O=c1c(c[nH]c2c(cnn12)-c1ccccn1)-c1ccsc1 InChI=1S/C15H10N4OS/c20-15-11(10-4-6-21-9-10)7-17-14-12(8-18-19(14)15)13-3-1-2-5-16-13/h1-9,17H AMPDVLJTHKQJOP-UHFFFAOYSA-N 50232200 CHEMBL4081736 Gamma-aminobutyric acid receptor subunit alpha-1 7 ChEMBL 10.1016/j.ejmech.2016.11.019 10.7270/Q2S184RN 27894044 Cherukupalli, S; Karpoormath, R; Chandrasekaran, B; Hampannavar, GA; Thapliyal, N; Palakollu, VN University of KwaZulu-Natal http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50232200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50232200&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 10108495 384226556 CHEMBL4081736 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 51121726 CCCCNC(=O)c1cc(ccc1O)-c1ccc(F)cc1F InChI=1S/C17H17F2NO2/c1-2-3-8-20-17(22)14-9-11(4-7-16(14)21)13-6-5-12(18)10-15(13)19/h4-7,9-10,21H,2-3,8H2,1H3,(H,20,22) PZLGAHXXFNKHIL-UHFFFAOYSA-N 50459891 CHEMBL4229086 Gamma-aminobutyric acid receptor subunit alpha-1 15000 ChEMBL 10.1016/j.bmcl.2017.04.073 10.7270/Q2MC92NR 28606760 Sparling, BA; DiMauro, EF Amgen Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50459891 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50459891&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 145988175 433927156 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 842419 Cc1cc(NC(=S)C(C#N)=C(O)C2CC2)ccc1C(F)(F)F InChI=1S/C15H13F3N2OS/c1-8-6-10(4-5-12(8)15(16,17)18)20-14(22)11(7-19)13(21)9-2-3-9/h4-6,9,21H,2-3H2,1H3,(H,20,22)/b13-11- UIRPMRWIBSSLRI-QBFSEMIESA-N 419122 US10472324, Example 1 Gamma-aminobutyric acid receptor subunit alpha-1 5300 US Patent 10.7270/Q2930WKT aid1803932 US10472324 Hasse, B; Koopmans, G ALGIAX PHARMACEUTICALS GMBH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419122&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 154584287 433918998 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 842420 Cc1cc(NC(=S)C(C#N)=C(O)C2CC2)ccc1F InChI=1S/C14H13FN2OS/c1-8-6-10(4-5-12(8)15)17-14(19)11(7-16)13(18)9-2-3-9/h4-6,9,18H,2-3H2,1H3,(H,17,19)/b13-11- RWWIKHOWVWFDJC-QBFSEMIESA-N 419125 US10472324, Example 2 Gamma-aminobutyric acid receptor subunit alpha-1 8300 US Patent 10.7270/Q2930WKT aid1803932 US10472324 Hasse, B; Koopmans, G ALGIAX PHARMACEUTICALS GMBH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419125&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 56832851 433919001 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 842421 Cc1cc(NC(=S)C(C#N)=C(O)C2CC2)ccc1[N+]([O-])=O InChI=1S/C14H13N3O3S/c1-8-6-10(4-5-12(8)17(19)20)16-14(21)11(7-15)13(18)9-2-3-9/h4-6,9,18H,2-3H2,1H3,(H,16,21)/b13-11- IBSIPBVZLUJGJO-QBFSEMIESA-N 419852 US10472324, Example 3 Gamma-aminobutyric acid receptor subunit alpha-1 6000 US Patent 10.7270/Q2930WKT aid1803932 US10472324 Hasse, B; Koopmans, G ALGIAX PHARMACEUTICALS GMBH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419852&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 842422 OC(C1CC1)=C(C#N)C(=S)Nc1ccc(cc1)[N+]([O-])=O InChI=1S/C13H11N3O3S/c14-7-11(12(17)8-1-2-8)13(20)15-9-3-5-10(6-4-9)16(18)19/h3-6,8,17H,1-2H2,(H,15,20)/b12-11- VEFSOJHIIIYBQC-QXMHVHEDSA-N 419901 US10472324, Example 4 Gamma-aminobutyric acid receptor subunit alpha-1 8700 US Patent 10.7270/Q2930WKT aid1803932 US10472324 Hasse, B; Koopmans, G ALGIAX PHARMACEUTICALS GMBH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419901&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 842423 OC(C1CC1)=C(C#N)C(=S)Nc1ccc(SC(F)(F)F)cc1 InChI=1S/C14H11F3N2OS2/c15-14(16,17)22-10-5-3-9(4-6-10)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,20H,1-2H2,(H,19,21)/b12-11- FPOJFINFXLGQLU-QXMHVHEDSA-N 419902 US10472324, Example 5 Gamma-aminobutyric acid receptor subunit alpha-1 7700 US Patent 10.7270/Q2930WKT aid1803932 US10472324 Hasse, B; Koopmans, G ALGIAX PHARMACEUTICALS GMBH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419902&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 842424 Cc1cc(NC(=S)C(C#N)=C(O)C2CC2)ccc1C#N InChI=1S/C15H13N3OS/c1-9-6-12(5-4-11(9)7-16)18-15(20)13(8-17)14(19)10-2-3-10/h4-6,10,19H,2-3H2,1H3,(H,18,20)/b14-13- CCDJPLLWQGXXHY-YPKPFQOOSA-N 419903 US10472324, Example 6 Gamma-aminobutyric acid receptor subunit alpha-1 7900 US Patent 10.7270/Q2930WKT aid1803932 US10472324 Hasse, B; Koopmans, G ALGIAX PHARMACEUTICALS GMBH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419903&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 842425 OC(C1CC1)=C(C#N)C(=S)Nc1ccc(cc1)C#N InChI=1S/C14H11N3OS/c15-7-9-1-5-11(6-2-9)17-14(19)12(8-16)13(18)10-3-4-10/h1-2,5-6,10,18H,3-4H2,(H,17,19)/b13-12- QOZKWEKWGYGOBX-SEYXRHQNSA-N 419904 US10472324, Example 7 Gamma-aminobutyric acid receptor subunit alpha-1 9600 US Patent 10.7270/Q2930WKT aid1803932 US10472324 Hasse, B; Koopmans, G ALGIAX PHARMACEUTICALS GMBH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419904&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 842426 OC(C1CC1)=C(C#N)C(=S)Nc1ccc(cc1)S(=O)C(F)(F)F InChI=1S/C14H11F3N2O2S2/c15-14(16,17)23(21)10-5-3-9(4-6-10)19-13(22)11(7-18)12(20)8-1-2-8/h3-6,8,20H,1-2H2,(H,19,22) ZWFOOPUTZMLKQI-UHFFFAOYSA-N 419905 US10472324, Example 8 Gamma-aminobutyric acid receptor subunit alpha-1 10300 US Patent 10.7270/Q2930WKT aid1803932 US10472324 Hasse, B; Koopmans, G ALGIAX PHARMACEUTICALS GMBH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419905&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 842427 OC(C1CC1)=C(C#N)C(=S)Nc1ccc(cc1)S(=O)(=O)C(F)(F)F InChI=1S/C14H11F3N2O3S2/c15-14(16,17)24(21,22)10-5-3-9(4-6-10)19-13(23)11(7-18)12(20)8-1-2-8/h3-6,8,20H,1-2H2,(H,19,23)/b12-11- WNHQGXIKUNCIMP-QXMHVHEDSA-N 419906 US10472324, Example 9 Gamma-aminobutyric acid receptor subunit alpha-1 5000 US Patent 10.7270/Q2930WKT aid1803932 US10472324 Hasse, B; Koopmans, G ALGIAX PHARMACEUTICALS GMBH http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=419906 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=419906&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100206 COC[C@]12CC[C@@](C)(O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](c4cc(CO)on4)[C@@]3(C)CC[C@H]21 InChI=1S/C25H39NO4/c1-23(28)10-11-25(15-29-3)16(13-23)4-5-18-19-6-7-21(22-12-17(14-27)30-26-22)24(19,2)9-8-20(18)25/h12,16,18-21,27-28H,4-11,13-15H2,1-3H3/t16-,18-,19-,20-,21+,23+,24-,25+/m0/s1 LUNLFPYLEIENQV-IOEAEITCSA-N 520646 US11147877, Compound 1 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520646&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452692 461598088 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100207 COC[C@]12CC[C@@](C)(O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](c4ccon4)[C@@]3(C)CC[C@H]21 InChI=1S/C24H37NO3/c1-22(26)11-12-24(15-27-3)16(14-22)4-5-17-18-6-7-20(21-9-13-28-25-21)23(18,2)10-8-19(17)24/h9,13,16-20,26H,4-8,10-12,14-15H2,1-3H3/t16-,17-,18-,19-,20+,22+,23-,24+/m0/s1 HSVMGBQHOHYKRT-CNRZDKSASA-N 520647 US11147877, Compound 2 Gamma-aminobutyric acid receptor subunit alpha-1 <20 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520647&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452697 461598089 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100208 COC[C@]12CC[C@@](C)(O)C[C@@H]1CC[C@H]1[C@@H]3CC[C@H](c4ccno4)[C@@]3(C)CC[C@H]21 InChI=1S/C24H37NO3/c1-22(26)11-12-24(15-27-3)16(14-22)4-5-17-18-6-7-20(21-9-13-25-28-21)23(18,2)10-8-19(17)24/h9,13,16-20,26H,4-8,10-12,14-15H2,1-3H3/t16-,17-,18-,19-,20+,22+,23-,24+/m0/s1 CPAOURUNSSMHQY-CNRZDKSASA-N 520652 US11147877, Compound 3 Gamma-aminobutyric acid receptor subunit alpha-1 350 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520652&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452678 461598094 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100209 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@]34C)[C@@H]1CC[C@@H]2c1cc(CO)on1 InChI=1S/C24H37NO3/c1-22(27)10-11-23(2)15(13-22)4-5-17-18-6-7-20(21-12-16(14-26)28-25-21)24(18,3)9-8-19(17)23/h12,15,17-20,26-27H,4-11,13-14H2,1-3H3/t15-,17+,18+,19+,20-,22-,23+,24+/m1/s1 WQANJTALVHXWJH-FLAZMILASA-N 520653 US11147877, Compound 4 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520653&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452655 461598095 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100210 COC[C@]12CC[C@@](C)(O)C[C@H]1CC[C@H]1[C@@H]3CC[C@H](c4cc(CO)on4)[C@@]3(C)CC[C@H]21 InChI=1S/C25H39NO4/c1-23(28)10-11-25(15-29-3)16(13-23)4-5-18-19-6-7-21(22-12-17(14-27)30-26-22)24(19,2)9-8-20(18)25/h12,16,18-21,27-28H,4-11,13-15H2,1-3H3/t16-,18+,19+,20+,21-,23-,24+,25-/m1/s1 LUNLFPYLEIENQV-DKXYLHMUSA-N 520654 US11147877, Compound 5 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520654&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452652 461598096 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100211 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2c1cc(CO)on1 InChI=1S/C23H35NO3/c1-22(26)9-7-16-14(12-22)3-4-18-17(16)8-10-23(2)19(18)5-6-20(23)21-11-15(13-25)27-24-21/h11,14,16-20,25-26H,3-10,12-13H2,1-2H3/t14-,16+,17-,18-,19+,20-,22-,23+/m1/s1 GVDKNWHDTOEIQM-LPHGGTRGSA-N 520656 US11147877, Compound 6::US11147877, Compound 8 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520656&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452660 461598098 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100212 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2c1ccon1 InChI=1S/C22H33NO2/c1-21(24)10-7-15-14(13-21)3-4-17-16(15)8-11-22(2)18(17)5-6-19(22)20-9-12-25-23-20/h9,12,14-19,24H,3-8,10-11,13H2,1-2H3/t14-,15+,16-,17-,18+,19-,21-,22+/m1/s1 SYGMNZNIEMEJOY-WMCSDWRFSA-N 520657 US11147877, Compound 7::US11147877, Compound 9 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520657&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452662 461598099 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100213 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2c1cc(CO)on1 InChI=1S/C23H35NO3/c1-22(26)9-7-16-14(12-22)3-4-18-17(16)8-10-23(2)19(18)5-6-20(23)21-11-15(13-25)27-24-21/h11,14,16-20,25-26H,3-10,12-13H2,1-2H3/t14-,16+,17-,18-,19+,20-,22-,23+/m1/s1 GVDKNWHDTOEIQM-LPHGGTRGSA-N 520656 US11147877, Compound 6::US11147877, Compound 8 Gamma-aminobutyric acid receptor subunit alpha-1 350 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520656&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452660 461598098 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100214 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2c1ccon1 InChI=1S/C22H33NO2/c1-21(24)10-7-15-14(13-21)3-4-17-16(15)8-11-22(2)18(17)5-6-19(22)20-9-12-25-23-20/h9,12,14-19,24H,3-8,10-11,13H2,1-2H3/t14-,15+,16-,17-,18+,19-,21-,22+/m1/s1 SYGMNZNIEMEJOY-WMCSDWRFSA-N 520657 US11147877, Compound 7::US11147877, Compound 9 Gamma-aminobutyric acid receptor subunit alpha-1 350 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520657&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452662 461598099 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100215 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@]34C)[C@@H]1CC[C@@H]2c1ccon1 InChI=1S/C23H35NO2/c1-21(25)11-12-22(2)15(14-21)4-5-16-17-6-7-19(20-9-13-26-24-20)23(17,3)10-8-18(16)22/h9,13,15-19,25H,4-8,10-12,14H2,1-3H3/t15-,16+,17+,18+,19-,21-,22+,23+/m1/s1 JZECESCKGJGLOO-HWLWJOIDSA-N 520660 US11147877, Compound 10 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520660&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452650 461598100 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100216 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@]34C)[C@@H]1CC[C@@H]2c1ccno1 InChI=1S/C23H35NO2/c1-21(25)11-12-22(2)15(14-21)4-5-16-17-6-7-19(20-9-13-24-26-20)23(17,3)10-8-18(16)22/h9,13,15-19,25H,4-8,10-12,14H2,1-3H3/t15-,16+,17+,18+,19-,21-,22+,23+/m1/s1 MYKTXJSIWSEOPB-HWLWJOIDSA-N 520661 US11147877, Compound 11::US11147877, Compound 18 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520661&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452657 461598101 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100217 COC[C@]12CC[C@@](C)(O)C[C@H]1CC[C@H]1[C@@H]3CC[C@H](c4cn5ccccc5n4)[C@@]3(C)CC[C@H]21 InChI=1S/C28H40N2O2/c1-26(31)13-14-28(18-32-3)19(16-26)7-8-20-21-9-10-23(27(21,2)12-11-22(20)28)24-17-30-15-5-4-6-25(30)29-24/h4-6,15,17,19-23,31H,7-14,16,18H2,1-3H3/t19-,20+,21+,22+,23-,26-,27+,28-/m1/s1 SJRSKUCOZQZQPF-JQDPGELQSA-N 520662 US11147877, Compound 12 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520662&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452674 461598102 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100218 COC[C@]12CC[C@@](C)(O)C[C@H]1CC[C@H]1[C@@H]3CC[C@H](c4ccno4)[C@@]3(C)CC[C@H]21 InChI=1S/C24H37NO3/c1-22(26)11-12-24(15-27-3)16(14-22)4-5-17-18-6-7-20(21-9-13-25-28-21)23(18,2)10-8-19(17)24/h9,13,16-20,26H,4-8,10-12,14-15H2,1-3H3/t16-,17+,18+,19+,20-,22-,23+,24-/m1/s1 CPAOURUNSSMHQY-MRKYCUEBSA-N 520663 US11147877, Compound 13 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520663&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452656 461598103 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100219 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2c1cn2ccccc2n1 InChI=1S/C26H36N2O/c1-25(29)12-10-18-17(15-25)6-7-20-19(18)11-13-26(2)21(20)8-9-22(26)23-16-28-14-4-3-5-24(28)27-23/h3-5,14,16-22,29H,6-13,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,25-,26+/m1/s1 JRPQBUMAHBNXQO-RFPARRRBSA-N 520664 US11147877, Compound 14 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520664&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 132100495 461598104 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100220 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@]34C)[C@@H]1CC[C@@H]2c1cn2ccccc2n1 InChI=1S/C27H38N2O/c1-25(30)13-14-26(2)18(16-25)7-8-19-20-9-10-22(27(20,3)12-11-21(19)26)23-17-29-15-5-4-6-24(29)28-23/h4-6,15,17-22,30H,7-14,16H2,1-3H3/t18-,19+,20+,21+,22-,25-,26+,27+/m1/s1 GRYOJALQYRLAAD-GYIOIMORSA-N 520665 US11147877, Compound 15 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520665&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452669 461598105 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100221 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2c1cn2ccccc2n1 InChI=1S/C26H36N2O/c1-25(29)12-10-18-17(15-25)6-7-20-19(18)11-13-26(2)21(20)8-9-22(26)23-16-28-14-4-3-5-24(28)27-23/h3-5,14,16-22,29H,6-13,15H2,1-2H3/t17-,18-,19+,20+,21-,22+,25+,26-/m0/s1 JRPQBUMAHBNXQO-ZNFWTZIQSA-N 520667 US11147877, Compound 16 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520667&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452671 461598107 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100222 COC[C@]12CC[C@@](C)(O)C[C@H]1CC[C@H]1[C@@H]3CC[C@H](c4ccon4)[C@@]3(C)CC[C@H]21 InChI=1S/C24H37NO3/c1-22(26)11-12-24(15-27-3)16(14-22)4-5-17-18-6-7-20(21-9-13-28-25-21)23(18,2)10-8-19(17)24/h9,13,16-20,26H,4-8,10-12,14-15H2,1-3H3/t16-,17+,18+,19+,20-,22-,23+,24-/m1/s1 HSVMGBQHOHYKRT-MRKYCUEBSA-N 520668 US11147877, Compound 17 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520668&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452649 461598108 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100223 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@]34C)[C@@H]1CC[C@@H]2c1ccno1 InChI=1S/C23H35NO2/c1-21(25)11-12-22(2)15(14-21)4-5-16-17-6-7-19(20-9-13-24-26-20)23(17,3)10-8-18(16)22/h9,13,15-19,25H,4-8,10-12,14H2,1-3H3/t15-,16+,17+,18+,19-,21-,22+,23+/m1/s1 MYKTXJSIWSEOPB-HWLWJOIDSA-N 520661 US11147877, Compound 11::US11147877, Compound 18 Gamma-aminobutyric acid receptor subunit alpha-1 110 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520661&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452657 461598101 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100224 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2c1ccno1 InChI=1S/C22H33NO2/c1-21(24)10-7-15-14(13-21)3-4-17-16(15)8-11-22(2)18(17)5-6-19(22)20-9-12-23-25-20/h9,12,14-19,24H,3-8,10-11,13H2,1-2H3/t14-,15-,16+,17+,18-,19+,21+,22-/m0/s1 POGSBWKWJQPTOB-HVOJCETBSA-N 520670 US11147877, Compound 19 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520670&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452665 461598109 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1100225 COC[C@]12CC[C@@](C)(O)C[C@@H]1CCC1[C@@H]3CC[C@H](c4cn5ccccc5n4)[C@@]3(C)CC[C@H]21 InChI=1S/C28H40N2O2/c1-26(31)13-14-28(18-32-3)19(16-26)7-8-20-21-9-10-23(27(21,2)12-11-22(20)28)24-17-30-15-5-4-6-25(30)29-24/h4-6,15,17,19-23,31H,7-14,16,18H2,1-3H3/t19-,20?,21-,22-,23+,26+,27-,28+/m0/s1 SJRSKUCOZQZQPF-LXSXHLSDSA-N 520671 US11147877, Compound 20 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2PZ5D0B aid1805990 US11147877 Robichaud, AJ; Martinez Botella, G; Salituro, FG; Harrison, BL Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=520671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=520671&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 122452658 461598110 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147037 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2ccccc12 InChI=1S/C28H38N2O2/c1-27(32)13-11-20-18(15-27)7-8-22-21(20)12-14-28(2)23(22)9-10-24(28)26(31)17-30-25-6-4-3-5-19(25)16-29-30/h3-6,16,18,20-24,32H,7-15,17H2,1-2H3/t18-,20+,21-,22-,23+,24-,27-,28+/m1/s1 PNRLOCDAUHBIHX-MOYGJMECSA-N 540741 US11261211, Compound SA-5 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540741 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540741&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298422 464925725 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147038 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc2cc(F)ccc2n1 InChI=1S/C28H37FN2O2/c1-27(33)11-9-20-17(14-27)3-5-22-21(20)10-12-28(2)23(22)6-7-24(28)26(32)16-31-15-18-13-19(29)4-8-25(18)30-31/h4,8,13,15,17,20-24,33H,3,5-7,9-12,14,16H2,1-2H3/t17-,20+,21-,22-,23+,24-,27-,28+/m1/s1 IGYLHMVJHLKPFU-WKJSGNJJSA-N 540742 US11261211, Compound SA-16 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540742 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540742&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86297808 464925726 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147039 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2cc(F)ccc12 InChI=1S/C28H37FN2O2/c1-27(33)11-9-20-17(14-27)3-5-22-21(20)10-12-28(2)23(22)6-7-24(28)26(32)16-31-25-8-4-19(29)13-18(25)15-30-31/h4,8,13,15,17,20-24,33H,3,5-7,9-12,14,16H2,1-2H3/t17-,20+,21-,22-,23+,24-,27-,28+/m1/s1 JDPAZUSBMGBABT-WKJSGNJJSA-N 540743 US11261211, Compound SA-17 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540743&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298011 464925727 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147040 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc2cccnc2n1 InChI=1S/C27H37N3O2/c1-26(32)11-9-19-17(14-26)5-6-21-20(19)10-12-27(2)22(21)7-8-23(27)24(31)16-30-15-18-4-3-13-28-25(18)29-30/h3-4,13,15,17,19-23,32H,5-12,14,16H2,1-2H3/t17-,19+,20-,21-,22+,23-,26-,27+/m1/s1 CMVZUGQWJUPOJA-BBRFPIJLSA-N 540744 US11261211, Compound SA-18 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540744 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540744&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298213 464925728 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147041 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2cccnc12 InChI=1S/C27H37N3O2/c1-26(32)11-9-19-17(14-26)5-6-21-20(19)10-12-27(2)22(21)7-8-23(27)24(31)16-30-25-18(15-29-30)4-3-13-28-25/h3-4,13,15,17,19-23,32H,5-12,14,16H2,1-2H3/t17-,19+,20-,21-,22+,23-,26-,27+/m1/s1 CKZVPJOTELQSHC-BBRFPIJLSA-N 540745 US11261211, Compound SA-19 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540745 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540745&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298424 464925729 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147042 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2ccncc12 InChI=1S/C27H37N3O2/c1-26(32)10-7-19-17(13-26)3-4-21-20(19)8-11-27(2)22(21)5-6-23(27)25(31)16-30-24-15-28-12-9-18(24)14-29-30/h9,12,14-15,17,19-23,32H,3-8,10-11,13,16H2,1-2H3/t17-,19+,20-,21-,22+,23-,26-,27+/m1/s1 MEWGBPFYMUBENF-BBRFPIJLSA-N 540746 US11261211, Compound SA-21 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540746 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540746&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663873 464925730 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147043 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2ccc(F)cc12 InChI=1S/C28H37FN2O2/c1-27(33)11-9-20-17(14-27)4-6-22-21(20)10-12-28(2)23(22)7-8-24(28)26(32)16-31-25-13-19(29)5-3-18(25)15-30-31/h3,5,13,15,17,20-24,33H,4,6-12,14,16H2,1-2H3/t17-,20+,21-,22-,23+,24-,27-,28+/m1/s1 IABOQYMUSPLWSE-WKJSGNJJSA-N 540747 US11261211, Compound SA-23 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540747 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540747&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663894 464925731 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147044 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nc2ccncc2n1 InChI=1S/C26H36N4O2/c1-25(32)10-7-17-16(13-25)3-4-19-18(17)8-11-26(2)20(19)5-6-21(26)24(31)15-30-28-22-9-12-27-14-23(22)29-30/h9,12,14,16-21,32H,3-8,10-11,13,15H2,1-2H3/t16-,17+,18-,19-,20+,21-,25-,26+/m1/s1 ZLBPCNGBTHIVDM-ZKLYXDDBSA-N 540748 US11261211, Compound SA-11 Gamma-aminobutyric acid receptor subunit alpha-1 <10 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540748 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540748&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663865 464925732 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147045 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2cnccc12 InChI=1S/C26H36N4O2/c1-25(32)10-7-17-16(13-25)3-4-19-18(17)8-11-26(2)20(19)5-6-21(26)24(31)15-30-23-9-12-27-14-22(23)28-29-30/h9,12,14,16-21,32H,3-8,10-11,13,15H2,1-2H3/t16-,17+,18-,19-,20+,21-,25-,26+/m1/s1 DXPMNAVMOQPNKO-ZKLYXDDBSA-N 540749 US11261211, Compound SA-12 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540749&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298215 464925733 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147046 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc2ccncc2n1 InChI=1S/C27H37N3O2/c1-26(32)10-7-19-17(13-26)3-4-21-20(19)8-11-27(2)22(21)5-6-23(27)25(31)16-30-15-18-9-12-28-14-24(18)29-30/h9,12,14-15,17,19-23,32H,3-8,10-11,13,16H2,1-2H3/t17-,19+,20-,21-,22+,23-,26-,27+/m1/s1 QCHBQARHFYCDNV-BBRFPIJLSA-N 540750 US11261211, Compound SA-20 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540750&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298423 464925734 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147047 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc2ccc(F)cc2n1 InChI=1S/C28H37FN2O2/c1-27(33)11-9-20-17(14-27)4-6-22-21(20)10-12-28(2)23(22)7-8-24(28)26(32)16-31-15-18-3-5-19(29)13-25(18)30-31/h3,5,13,15,17,20-24,33H,4,6-12,14,16H2,1-2H3/t17-,20+,21-,22-,23+,24-,27-,28+/m1/s1 OBTDHIZKJNYVEG-WKJSGNJJSA-N 540751 US11261211, Compound SA-22 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540751 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540751&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86297806 464925735 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147048 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ncccc12 InChI=1S/C26H36N4O2/c1-25(32)11-9-17-16(14-25)5-6-19-18(17)10-12-26(2)20(19)7-8-21(26)23(31)15-30-22-4-3-13-27-24(22)28-29-30/h3-4,13,16-21,32H,5-12,14-15H2,1-2H3/t16-,17+,18-,19-,20+,21-,25-,26+/m1/s1 WCLHZIAKMBMZAK-ZKLYXDDBSA-N 540752 US11261211, Compound SA-13 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540752 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540752&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298216 464925736 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147049 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nc2cccnc2n1 InChI=1S/C26H36N4O2/c1-25(32)11-9-17-16(14-25)5-6-19-18(17)10-12-26(2)20(19)7-8-21(26)23(31)15-30-28-22-4-3-13-27-24(22)29-30/h3-4,13,16-21,32H,5-12,14-15H2,1-2H3/t16-,17+,18-,19-,20+,21-,25-,26+/m1/s1 OOTSHVFCAFQRGH-ZKLYXDDBSA-N 540753 US11261211, Compound SA-14 Gamma-aminobutyric acid receptor subunit alpha-1 <10 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540753&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298008 464925737 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147050 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2cccnc12 InChI=1S/C26H36N4O2/c1-25(32)11-9-17-16(14-25)5-6-19-18(17)10-12-26(2)20(19)7-8-21(26)23(31)15-30-24-22(28-29-30)4-3-13-27-24/h3-4,13,16-21,32H,5-12,14-15H2,1-2H3/t16-,17+,18-,19-,20+,21-,25-,26+/m1/s1 IEVBHICQBKQFKA-ZKLYXDDBSA-N 540754 US11261211, Compound SA-15 Gamma-aminobutyric acid receptor subunit alpha-1 <10 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540754&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298010 464925738 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147051 Cn1c(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)nc2ccccc12 InChI=1S/C29H40N2O2/c1-28(33)14-12-19-18(17-28)8-9-21-20(19)13-15-29(2)22(21)10-11-23(29)26(32)16-27-30-24-6-4-5-7-25(24)31(27)3/h4-7,18-23,33H,8-17H2,1-3H3/t18-,19+,20-,21-,22+,23-,28-,29+/m1/s1 CDSDFLHDUCVXBO-BFDNQYNMSA-N 540755 US11261211, Compound SA-10::US11261211, Compound SA-105 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540755&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663840 464925739 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147052 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nc2ccccc2c1O InChI=1S/C28H38N2O3/c1-27(33)13-11-18-17(15-27)7-8-20-19(18)12-14-28(2)22(20)9-10-23(28)25(31)16-30-26(32)21-5-3-4-6-24(21)29-30/h3-6,17-20,22-23,32-33H,7-16H2,1-2H3/t17-,18+,19-,20-,22+,23-,27-,28+/m1/s1 MMEAXXLLQXSJCX-LJPUPWNHSA-N 540756 US11261211, Compound SA-54 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540756&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663900 464925740 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147053 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2cc(Cl)ccc12 InChI=1S/C27H36ClN3O2/c1-26(33)11-9-18-16(14-26)3-5-20-19(18)10-12-27(2)21(20)6-7-22(27)25(32)15-31-24-8-4-17(28)13-23(24)29-30-31/h4,8,13,16,18-22,33H,3,5-7,9-12,14-15H2,1-2H3/t16-,18+,19-,20-,21+,22-,26-,27+/m1/s1 OGQWUOGYTPFKRA-CEBQRTKQSA-N 540758 US11261211, Compound SA-40 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540758&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663812 464925742 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147054 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccc(Cl)cc12 InChI=1S/C27H36ClN3O2/c1-26(33)11-9-18-16(14-26)3-5-20-19(18)10-12-27(2)21(20)6-7-22(27)25(32)15-31-24-13-17(28)4-8-23(24)29-30-31/h4,8,13,16,18-22,33H,3,5-7,9-12,14-15H2,1-2H3/t16-,18+,19-,20-,21+,22-,26-,27+/m1/s1 PSUWYHKJLHROJI-CEBQRTKQSA-N 540759 US11261211, Compound SA-39 Gamma-aminobutyric acid receptor subunit alpha-1 <10 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540759&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663811 464925743 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147055 COc1ccc2nn(CC(=O)[C@H]3CC[C@H]4[C@@H]5CC[C@@H]6C[C@](C)(O)CC[C@@H]6[C@H]5CC[C@]34C)nc2c1 InChI=1S/C28H39N3O3/c1-27(33)12-10-19-17(15-27)4-6-21-20(19)11-13-28(2)22(21)7-8-23(28)26(32)16-31-29-24-9-5-18(34-3)14-25(24)30-31/h5,9,14,17,19-23,33H,4,6-8,10-13,15-16H2,1-3H3/t17-,19+,20-,21-,22+,23-,27-,28+/m1/s1 SZQDGVNMPGIAJV-CCZABAJOSA-N 540760 US11261211, Compound SB-49 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540760&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663893 464925744 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147056 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2cc(F)c(F)cc12 InChI=1S/C27H35F2N3O2/c1-26(34)9-7-16-15(13-26)3-4-18-17(16)8-10-27(2)19(18)5-6-20(27)25(33)14-32-24-12-22(29)21(28)11-23(24)30-31-32/h11-12,15-20,34H,3-10,13-14H2,1-2H3/t15-,16+,17-,18-,19+,20-,26-,27+/m1/s1 HTQSQIYGJWANBC-DCJZMTJOSA-N 540761 US11261211, Compound SB-50 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540761&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663899 464925745 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147057 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nc(Cl)c2ccccc12 InChI=1S/C28H37ClN2O2/c1-27(33)13-11-18-17(15-27)7-8-20-19(18)12-14-28(2)22(20)9-10-23(28)25(32)16-31-24-6-4-3-5-21(24)26(29)30-31/h3-6,17-20,22-23,33H,7-16H2,1-2H3/t17-,18+,19-,20-,22+,23-,27-,28+/m1/s1 NHJLQICRKQEBRR-LJPUPWNHSA-N 540762 US11261211, Compound SA-55 Gamma-aminobutyric acid receptor subunit alpha-1 <10 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540762&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663844 464925746 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147058 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc2ncccc2n1 InChI=1S/C27H36FN3O2/c1-26-10-8-19-18-9-11-27(33,16-28)13-17(18)4-5-20(19)21(26)6-7-22(26)25(32)15-31-14-24-23(30-31)3-2-12-29-24/h2-3,12,14,17-22,33H,4-11,13,15-16H2,1H3/t17-,18+,19-,20-,21+,22-,26+,27-/m1/s1 KVVUNLRILBIQLZ-QIBPWSOXSA-N 540763 US11261211, Compound SA-83 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540763&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663933 464925747 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147059 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2ncccc12 InChI=1S/C27H36FN3O2/c1-26-10-8-19-18-9-11-27(33,16-28)13-17(18)4-5-20(19)21(26)6-7-22(26)25(32)15-31-24-3-2-12-29-23(24)14-30-31/h2-3,12,14,17-22,33H,4-11,13,15-16H2,1H3/t17-,18+,19-,20-,21+,22-,26+,27-/m1/s1 UYURWWNYXPLBCN-QIBPWSOXSA-N 540764 US11261211, Compound SA-84 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540764&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663932 464925748 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147060 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ncc(Cl)cc12 InChI=1S/C26H35ClN4O2/c1-25(33)9-7-17-15(12-25)3-4-19-18(17)8-10-26(2)20(19)5-6-21(26)23(32)14-31-22-11-16(27)13-28-24(22)29-30-31/h11,13,15,17-21,33H,3-10,12,14H2,1-2H3/t15-,17+,18-,19-,20+,21-,25-,26+/m1/s1 SFQLVWHHQAUHQU-VNEQACEKSA-N 540765 US11261211, Compound SA-56 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540765&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663948 464925749 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147061 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nc2cc(Cl)cnc2n1 InChI=1S/C26H35ClN4O2/c1-25(33)9-7-17-15(12-25)3-4-19-18(17)8-10-26(2)20(19)5-6-21(26)23(32)14-31-29-22-11-16(27)13-28-24(22)30-31/h11,13,15,17-21,33H,3-10,12,14H2,1-2H3/t15-,17+,18-,19-,20+,21-,25-,26+/m1/s1 ORPOGLQVFFJOPQ-VNEQACEKSA-N 540766 US11261211, Compound SA-57 Gamma-aminobutyric acid receptor subunit alpha-1 <10 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540766&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663949 464925750 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147062 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2cc(Cl)cnc12 InChI=1S/C26H35ClN4O2/c1-25(33)9-7-17-15(12-25)3-4-19-18(17)8-10-26(2)20(19)5-6-21(26)23(32)14-31-24-22(29-30-31)11-16(27)13-28-24/h11,13,15,17-21,33H,3-10,12,14H2,1-2H3/t15-,17+,18-,19-,20+,21-,25-,26+/m1/s1 QLNBLHRNBBUTRF-VNEQACEKSA-N 540767 US11261211, Compound SA-58 Gamma-aminobutyric acid receptor subunit alpha-1 <10 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540767&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663947 464925751 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147063 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccccc12 InChI=1S/C27H37N3O2/c1-26(32)13-11-18-17(15-26)7-8-20-19(18)12-14-27(2)21(20)9-10-22(27)25(31)16-30-24-6-4-3-5-23(24)28-29-30/h3-6,17-22,32H,7-16H2,1-2H3/t17-,18-,19+,20+,21-,22+,26+,27-/m0/s1 YSQQDSTXXNAQID-PYTYXIMMSA-N 540768 US11261211, Compound SB-1 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540768&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663875 464925752 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147064 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nc2ccccc2n1 InChI=1S/C27H37N3O2/c1-26(32)13-11-18-17(15-26)7-8-20-19(18)12-14-27(2)21(20)9-10-22(27)25(31)16-30-28-23-5-3-4-6-24(23)29-30/h3-6,17-22,32H,7-16H2,1-2H3/t17-,18-,19+,20+,21-,22+,26+,27-/m0/s1 CCQLFFXLUNBTNR-PYTYXIMMSA-N 540769 US11261211, Compound SB-2 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540769&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663867 464925753 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147065 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccccc12 InChI=1S/C27H36FN3O2/c1-26-12-10-19-18-11-13-27(33,16-28)14-17(18)6-7-20(19)21(26)8-9-22(26)25(32)15-31-24-5-3-2-4-23(24)29-30-31/h2-5,17-22,33H,6-16H2,1H3/t17-,18-,19+,20+,21-,22+,26-,27+/m0/s1 SRNDDAGADSAVAP-AECCJQPVSA-N 540770 US11261211, Compound SB-12 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540770&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663838 464925754 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147066 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nc2ccccc2n1 InChI=1S/C27H36FN3O2/c1-26-12-10-19-18-11-13-27(33,16-28)14-17(18)6-7-20(19)21(26)8-9-22(26)25(32)15-31-29-23-4-2-3-5-24(23)30-31/h2-5,17-22,33H,6-16H2,1H3/t17-,18-,19+,20+,21-,22+,26-,27+/m0/s1 RBRZZUHOTAEXMT-AECCJQPVSA-N 540771 US11261211, Compound SB-13 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540771&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663852 464925755 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147067 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2cnccc12 InChI=1S/C26H35FN4O2/c1-25-9-6-18-17-7-10-26(33,15-27)12-16(17)2-3-19(18)20(25)4-5-21(25)24(32)14-31-23-8-11-28-13-22(23)29-30-31/h8,11,13,16-21,33H,2-7,9-10,12,14-15H2,1H3/t16-,17-,18+,19+,20-,21+,25-,26+/m0/s1 FTZYVQGZJNKUFA-NMAPPNDSSA-N 540772 US11261211, Compound SB-14 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540772&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663853 464925756 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147068 CC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nc6ccncc6n5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C27H38N4O2/c1-3-27(33)12-9-18-17(14-27)4-5-20-19(18)8-11-26(2)21(20)6-7-22(26)25(32)16-31-29-23-10-13-28-15-24(23)30-31/h10,13,15,17-22,33H,3-9,11-12,14,16H2,1-2H3/t17-,18-,19+,20+,21-,22+,26-,27+/m0/s1 HREDNBAQALBCBO-AECCJQPVSA-N 540773 US11261211, Compound SB-15 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540773 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540773&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663884 464925757 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147069 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](O)(CC[C@H]34)C(F)F)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccccc12 InChI=1S/C27H35F2N3O2/c1-26-12-10-18-17-11-13-27(34,25(28)29)14-16(17)6-7-19(18)20(26)8-9-21(26)24(33)15-32-23-5-3-2-4-22(23)30-31-32/h2-5,16-21,25,34H,6-15H2,1H3/t16-,17+,18-,19-,20+,21-,26+,27-/m1/s1 IKDNMNYXNGZQKN-ATDMNIQZSA-N 540774 US11261211, Compound SA-90 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540774 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540774&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663814 464925758 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147070 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2ncccc12 InChI=1S/C27H36FN3O2/c1-26-10-8-19-18-9-11-27(33,16-28)13-17(18)4-5-20(19)21(26)6-7-22(26)25(32)15-31-24-3-2-12-29-23(24)14-30-31/h2-3,12,14,17-22,33H,4-11,13,15-16H2,1H3/t17-,18-,19+,20+,21-,22+,26-,27+/m0/s1 UYURWWNYXPLBCN-AECCJQPVSA-N 540775 US11261211, Compound SB-17 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540775 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540775&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663837 464925759 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147071 COC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5cc6ccncc6n5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H39N3O3/c1-27-10-7-21-20-8-11-28(33,17-34-2)13-18(20)3-4-22(21)23(27)5-6-24(27)26(32)16-31-15-19-9-12-29-14-25(19)30-31/h9,12,14-15,18,20-24,33H,3-8,10-11,13,16-17H2,1-2H3/t18-,20-,21+,22+,23-,24+,27-,28+/m0/s1 FMSCUVBJUOMFLY-CMIMXMIGSA-N 540776 US11261211, Compound SB-45 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540776 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540776&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663832 464925760 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147072 COC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5ncc6ccncc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H39N3O3/c1-27-10-7-21-20-8-11-28(33,17-34-2)13-18(20)3-4-22(21)23(27)5-6-24(27)26(32)16-31-25-15-29-12-9-19(25)14-30-31/h9,12,14-15,18,20-24,33H,3-8,10-11,13,16-17H2,1-2H3/t18-,20-,21+,22+,23-,24+,27-,28+/m0/s1 OGDRYTNTGWZAJZ-CMIMXMIGSA-N 540777 US11261211, Compound SB-46 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540777 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540777&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663830 464925761 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147073 CCOC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nc6ccccc6n5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C29H41N3O3/c1-3-35-18-29(34)15-13-20-19(16-29)8-9-22-21(20)12-14-28(2)23(22)10-11-24(28)27(33)17-32-30-25-6-4-5-7-26(25)31-32/h4-7,19-24,34H,3,8-18H2,1-2H3/t19-,20-,21+,22+,23-,24+,28-,29+/m0/s1 CFASCYPOOGHGMO-NRVINDOTSA-N 540778 US11261211, Compound SB-53 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540778 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540778&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663943 464925762 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147074 CCOC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5ncc6ccncc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C29H41N3O3/c1-3-35-18-29(34)12-9-21-19(14-29)4-5-23-22(21)8-11-28(2)24(23)6-7-25(28)27(33)17-32-26-16-30-13-10-20(26)15-31-32/h10,13,15-16,19,21-25,34H,3-9,11-12,14,17-18H2,1-2H3/t19-,21-,22+,23+,24-,25+,28-,29+/m0/s1 OJOYOGFQHNYUAT-SRUXIRMTSA-N 540779 US11261211, Compound SB-56 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540779 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540779&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663822 464925763 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147075 CC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6ccccc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H39N3O2/c1-3-28(33)15-13-19-18(16-28)8-9-21-20(19)12-14-27(2)22(21)10-11-23(27)26(32)17-31-25-7-5-4-6-24(25)29-30-31/h4-7,18-23,33H,3,8-17H2,1-2H3/t18-,19-,20+,21+,22-,23+,27-,28+/m0/s1 IJRJHAZGBBJBRX-YISWOJJGSA-N 540780 US11261211, Compound SB-35 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540780 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540780&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663881 464925764 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147076 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2cc(Cl)ncc12 InChI=1S/C27H36ClN3O2/c1-26(33)9-7-18-16(12-26)3-4-20-19(18)8-10-27(2)21(20)5-6-22(27)24(32)15-31-23-14-29-25(28)11-17(23)13-30-31/h11,13-14,16,18-22,33H,3-10,12,15H2,1-2H3/t16-,18+,19-,20-,21+,22-,26-,27+/m1/s1 DDVFOWWFGKAZHH-CEBQRTKQSA-N 540781 US11261211, Compound SA-31 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540781 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540781&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663846 464925765 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147077 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](O)(CC[C@H]34)C(F)F)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2ccncc12 InChI=1S/C27H35F2N3O2/c1-26-9-6-19-18-7-10-27(34,25(28)29)12-16(18)2-3-20(19)21(26)4-5-22(26)24(33)15-32-23-14-30-11-8-17(23)13-31-32/h8,11,13-14,16,18-22,25,34H,2-7,9-10,12,15H2,1H3/t16-,18+,19-,20-,21+,22-,26+,27-/m1/s1 ZQQLVRROUMVXEF-XXQSPUMYSA-N 540782 US11261211, Compound SA-100 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540782 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540782&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663902 464925766 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147078 COc1ccc2nn(CC(=O)[C@H]3CC[C@H]4[C@@H]5CC[C@H]6C[C@@](O)(CF)CC[C@@H]6[C@H]5CC[C@]34C)nc2c1 InChI=1S/C28H38FN3O3/c1-27-11-9-20-19-10-12-28(34,16-29)14-17(19)3-5-21(20)22(27)6-7-23(27)26(33)15-32-30-24-8-4-18(35-2)13-25(24)31-32/h4,8,13,17,19-23,34H,3,5-7,9-12,14-16H2,1-2H3/t17-,19-,20+,21+,22-,23+,27-,28+/m0/s1 WJAHLSZJVXUDSS-AINROVSSSA-N 540783 US11261211, Compound SG-21 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540783 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540783&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663863 464925767 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147079 COc1ccc2n(CC(=O)[C@H]3CC[C@H]4[C@@H]5CC[C@H]6C[C@@](O)(CF)CC[C@@H]6[C@H]5CC[C@]34C)nnc2c1 InChI=1S/C28H38FN3O3/c1-27-11-9-20-19-10-12-28(34,16-29)14-17(19)3-5-21(20)22(27)6-7-23(27)26(33)15-32-25-8-4-18(35-2)13-24(25)30-31-32/h4,8,13,17,19-23,34H,3,5-7,9-12,14-16H2,1-2H3/t17-,19-,20+,21+,22-,23+,27-,28+/m0/s1 HQXXXYDQYPCLBN-AINROVSSSA-N 540784 US11261211, Compound SG-23 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540784 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540784&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663860 464925768 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147080 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccncc12 InChI=1S/C26H35FN4O2/c1-25-9-6-18-17-7-10-26(33,15-27)12-16(17)2-3-19(18)20(25)4-5-21(25)24(32)14-31-23-13-28-11-8-22(23)29-30-31/h8,11,13,16-21,33H,2-7,9-10,12,14-15H2,1H3/t16-,17-,18+,19+,20-,21+,25-,26+/m0/s1 ULQPMTUSRLDKLQ-NMAPPNDSSA-N 540786 US11261211, Compound SB-26 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540786&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663825 464925770 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147081 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2cc(OC(F)(F)F)ccc12 InChI=1S/C28H36F3N3O3/c1-26(36)11-9-18-16(14-26)3-5-20-19(18)10-12-27(2)21(20)6-7-22(27)25(35)15-34-24-8-4-17(37-28(29,30)31)13-23(24)32-33-34/h4,8,13,16,18-22,36H,3,5-7,9-12,14-15H2,1-2H3/t16-,18+,19-,20-,21+,22-,26-,27+/m1/s1 HJBHXQDCRQZBKC-CEBQRTKQSA-N 540787 US11261211, Compound SA-70 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540787 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540787&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663918 464925771 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147082 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccc(OC(F)(F)F)cc12 InChI=1S/C28H36F3N3O3/c1-26(36)11-9-18-16(14-26)3-5-20-19(18)10-12-27(2)21(20)6-7-22(27)25(35)15-34-24-13-17(37-28(29,30)31)4-8-23(24)32-33-34/h4,8,13,16,18-22,36H,3,5-7,9-12,14-15H2,1-2H3/t16-,18+,19-,20-,21+,22-,26-,27+/m1/s1 MGPUJYSBPQGDGD-CEBQRTKQSA-N 540788 US11261211, Compound SA-71 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540788 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540788&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663905 464925772 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147083 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccc(F)cc12 InChI=1S/C27H35F2N3O2/c1-26-10-8-19-18-9-11-27(34,15-28)13-16(18)2-4-20(19)21(26)5-6-22(26)25(33)14-32-24-12-17(29)3-7-23(24)30-31-32/h3,7,12,16,18-22,34H,2,4-6,8-11,13-15H2,1H3/t16-,18-,19+,20+,21-,22+,26-,27+/m0/s1 OSLIAASHJNHDJW-UDRRHPMUSA-N 540789 US11261211, Compound SG-25 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540789 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540789&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663882 464925773 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147084 COC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nc6ccc(F)cc6n5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H38FN3O3/c1-27-11-9-20-19-10-12-28(34,16-35-2)14-17(19)3-5-21(20)22(27)6-7-23(27)26(33)15-32-30-24-8-4-18(29)13-25(24)31-32/h4,8,13,17,19-23,34H,3,5-7,9-12,14-16H2,1-2H3/t17-,19-,20+,21+,22-,23+,27-,28+/m0/s1 VCXWBJSCWHABSI-AINROVSSSA-N 540790 US11261211, Compound SB-41 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540790&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663965 464925774 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147085 CC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nc6ccc(F)cc6n5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H38FN3O2/c1-3-28(34)13-11-19-17(15-28)4-6-21-20(19)10-12-27(2)22(21)7-8-23(27)26(33)16-32-30-24-9-5-18(29)14-25(24)31-32/h5,9,14,17,19-23,34H,3-4,6-8,10-13,15-16H2,1-2H3/t17-,19-,20+,21+,22-,23+,27-,28+/m0/s1 KTONWRDIEJBFCQ-AINROVSSSA-N 540791 US11261211, Compound SB-39 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540791 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540791&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663831 464925775 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147086 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](O)(CC[C@H]34)C(F)F)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2cc(F)ccc12 InChI=1S/C27H34F3N3O2/c1-26-10-8-18-17-9-11-27(35,25(29)30)13-15(17)2-4-19(18)20(26)5-6-21(26)24(34)14-33-23-7-3-16(28)12-22(23)31-32-33/h3,7,12,15,17-21,25,35H,2,4-6,8-11,13-14H2,1H3/t15-,17+,18-,19-,20+,21-,26+,27-/m1/s1 NJHGDOKQBZZKCH-WBHQXWLVSA-N 540792 US11261211, Compound SA-102 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540792 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540792&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86297608 464925776 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147087 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](O)(CC[C@H]34)C(F)F)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccc(F)cc12 InChI=1S/C27H34F3N3O2/c1-26-10-8-18-17-9-11-27(35,25(29)30)13-15(17)2-4-19(18)20(26)5-6-21(26)24(34)14-33-23-12-16(28)3-7-22(23)31-32-33/h3,7,12,15,17-21,25,35H,2,4-6,8-11,13-14H2,1H3/t15-,17+,18-,19-,20+,21-,26+,27-/m1/s1 HBUXVRXWIVIEEX-WBHQXWLVSA-N 540793 US11261211, Compound SA-103 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540793 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540793&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86296622 464925777 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147088 COC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6cc(F)ccc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H38FN3O3/c1-27-11-9-20-19-10-12-28(34,16-35-2)14-17(19)3-5-21(20)22(27)6-7-23(27)26(33)15-32-25-8-4-18(29)13-24(25)30-31-32/h4,8,13,17,19-23,34H,3,5-7,9-12,14-16H2,1-2H3/t17-,19+,20-,21-,22+,23-,27+,28-/m1/s1 ARZNTAOKTDIDLL-QXRDIQQYSA-N 540794 US11261211, Compound SA-120 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540794&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663921 464925778 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147089 COC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6ccc(F)cc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H38FN3O3/c1-27-11-9-20-19-10-12-28(34,16-35-2)14-17(19)3-5-21(20)22(27)6-7-23(27)26(33)15-32-25-13-18(29)4-8-24(25)30-31-32/h4,8,13,17,19-23,34H,3,5-7,9-12,14-16H2,1-2H3/t17-,19+,20-,21-,22+,23-,27+,28-/m1/s1 SPMJMRHOOWMIAG-QXRDIQQYSA-N 540795 US11261211, Compound SA-121 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540795 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540795&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86297012 464925779 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147090 CCOC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nc6ccc(F)cc6n5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C29H40FN3O3/c1-3-36-17-29(35)13-11-20-18(15-29)4-6-22-21(20)10-12-28(2)23(22)7-8-24(28)27(34)16-33-31-25-9-5-19(30)14-26(25)32-33/h5,9,14,18,20-24,35H,3-4,6-8,10-13,15-17H2,1-2H3/t18-,20-,21+,22+,23-,24+,28-,29+/m0/s1 DNVVNFIFOSDOSG-MSKYNDJWSA-N 540796 US11261211, Compound SB-60 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540796 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540796&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663987 464925780 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147091 CC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6cc(F)ccc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H38FN3O2/c1-3-28(34)13-11-19-17(15-28)4-6-21-20(19)10-12-27(2)22(21)7-8-23(27)26(33)16-32-25-9-5-18(29)14-24(25)30-31-32/h5,9,14,17,19-23,34H,3-4,6-8,10-13,15-16H2,1-2H3/t17-,19-,20+,21+,22-,23+,27-,28+/m0/s1 RUMBZFPKNKUYKK-AINROVSSSA-N 540797 US11261211, Compound SB-37 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540797 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540797&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663821 464925781 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147092 CC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6ccc(F)cc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H38FN3O2/c1-3-28(34)13-11-19-17(15-28)4-6-21-20(19)10-12-27(2)22(21)7-8-23(27)26(33)16-32-25-14-18(29)5-9-24(25)30-31-32/h5,9,14,17,19-23,34H,3-4,6-8,10-13,15-16H2,1-2H3/t17-,19-,20+,21+,22-,23+,27-,28+/m0/s1 RNOYZLHTOHFHGZ-AINROVSSSA-N 540798 US11261211, Compound SB-38 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540798 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540798&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663827 464925782 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147093 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nc2cc(F)c(F)cc2n1 InChI=1S/C27H35F2N3O2/c1-26(34)9-7-16-15(13-26)3-4-18-17(16)8-10-27(2)19(18)5-6-20(27)25(33)14-32-30-23-11-21(28)22(29)12-24(23)31-32/h11-12,15-20,34H,3-10,13-14H2,1-2H3/t15-,16+,17-,18-,19+,20-,26-,27+/m1/s1 WOKJEACRUWOKDC-DCJZMTJOSA-N 540799 Compound SA-51::US11261211, Compound SA-53 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540799 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540799&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663898 464925783 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147094 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2cc(F)ccc12 InChI=1S/C27H35F2N3O2/c1-26-10-8-19-18-9-11-27(34,15-28)13-16(18)2-4-20(19)21(26)5-6-22(26)25(33)14-32-24-7-3-17(29)12-23(24)30-31-32/h3,7,12,16,18-22,34H,2,4-6,8-11,13-15H2,1H3/t16-,18+,19-,20-,21+,22-,26+,27-/m1/s1 MMBOBNPZOJQJOM-XXQSPUMYSA-N 540800 US11261211, Compound SA-87 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540800 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540800&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663809 464925784 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147095 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccc(F)cc12 InChI=1S/C27H35F2N3O2/c1-26-10-8-19-18-9-11-27(34,15-28)13-16(18)2-4-20(19)21(26)5-6-22(26)25(33)14-32-24-12-17(29)3-7-23(24)30-31-32/h3,7,12,16,18-22,34H,2,4-6,8-11,13-15H2,1H3/t16-,18+,19-,20-,21+,22-,26+,27-/m1/s1 OSLIAASHJNHDJW-XXQSPUMYSA-N 540801 US11261211, Compound SA-88 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540801 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540801&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86296229 464925785 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147096 COC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6ccc(F)cc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H38FN3O3/c1-27-11-9-20-19-10-12-28(34,16-35-2)14-17(19)3-5-21(20)22(27)6-7-23(27)26(33)15-32-25-13-18(29)4-8-24(25)30-31-32/h4,8,13,17,19-23,34H,3,5-7,9-12,14-16H2,1-2H3/t17-,19-,20+,21+,22-,23+,27-,28+/m0/s1 SPMJMRHOOWMIAG-AINROVSSSA-N 540802 US11261211, Compound SB-40 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540802 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540802&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663964 464925786 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147097 CCOC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6cc(F)ccc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C29H40FN3O3/c1-3-36-17-29(35)13-11-20-18(15-29)4-6-22-21(20)10-12-28(2)23(22)7-8-24(28)27(34)16-33-26-9-5-19(30)14-25(26)31-32-33/h5,9,14,18,20-24,35H,3-4,6-8,10-13,15-17H2,1-2H3/t18-,20+,21-,22-,23+,24-,28+,29-/m1/s1 NFXZTIULKOZJCE-IFLODVFJSA-N 540803 US11261211, Compound SA-126 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540803 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540803&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663935 464925787 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147098 CCOC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6ccc(F)cc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C29H40FN3O3/c1-3-36-17-29(35)13-11-20-18(15-29)4-6-22-21(20)10-12-28(2)23(22)7-8-24(28)27(34)16-33-26-14-19(30)5-9-25(26)31-32-33/h5,9,14,18,20-24,35H,3-4,6-8,10-13,15-17H2,1-2H3/t18-,20+,21-,22-,23+,24-,28+,29-/m1/s1 NIRLCNDACBJLIL-IFLODVFJSA-N 540804 US11261211, Compound SA-127 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540804 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540804&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86297401 464925788 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147099 CCOC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nc6ccc(F)cc6n5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C29H40FN3O3/c1-3-36-17-29(35)13-11-20-18(15-29)4-6-22-21(20)10-12-28(2)23(22)7-8-24(28)27(34)16-33-31-25-9-5-19(30)14-26(25)32-33/h5,9,14,18,20-24,35H,3-4,6-8,10-13,15-17H2,1-2H3/t18-,20+,21-,22-,23+,24-,28+,29-/m1/s1 DNVVNFIFOSDOSG-IFLODVFJSA-N 540806 US11261211, Compound SA-128 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540806&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663829 464925790 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147100 CC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6cc(F)ccc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H38FN3O2/c1-3-28(34)13-11-19-17(15-28)4-6-21-20(19)10-12-27(2)22(21)7-8-23(27)26(33)16-32-25-9-5-18(29)14-24(25)30-31-32/h5,9,14,17,19-23,34H,3-4,6-8,10-13,15-16H2,1-2H3/t17-,19+,20-,21-,22+,23-,27+,28-/m1/s1 RUMBZFPKNKUYKK-QXRDIQQYSA-N 540807 US11261211, Compound SA-107 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540807 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540807&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663848 464925791 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147101 CC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)Cn5nnc6ccc(F)cc56)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H38FN3O2/c1-3-28(34)13-11-19-17(15-28)4-6-21-20(19)10-12-27(2)22(21)7-8-23(27)26(33)16-32-25-14-18(29)5-9-24(25)30-31-32/h5,9,14,17,19-23,34H,3-4,6-8,10-13,15-16H2,1-2H3/t17-,19+,20-,21-,22+,23-,27+,28-/m1/s1 RNOYZLHTOHFHGZ-QXRDIQQYSA-N 540808 US11261211, Compound SA-108 Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540808 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540808&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86296015 464925792 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147102 Cn1c(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)nc2ccccc12 InChI=1S/C29H40N2O2/c1-28(33)14-12-19-18(17-28)8-9-21-20(19)13-15-29(2)22(21)10-11-23(29)26(32)16-27-30-24-6-4-5-7-25(24)31(27)3/h4-7,18-23,33H,8-17H2,1-3H3/t18-,19+,20-,21-,22+,23-,28-,29+/m1/s1 CDSDFLHDUCVXBO-BFDNQYNMSA-N 540755 US11261211, Compound SA-10::US11261211, Compound SA-105 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540755&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663840 464925739 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147103 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cc1nccc2ccccc12 InChI=1S/C30H39NO2/c1-29(33)14-11-21-20(18-29)7-8-24-23(21)12-15-30(2)25(24)9-10-26(30)28(32)17-27-22-6-4-3-5-19(22)13-16-31-27/h3-6,13,16,20-21,23-26,33H,7-12,14-15,17-18H2,1-2H3/t20-,21+,23-,24-,25+,26-,29-,30+/m1/s1 VAFZCEGZEXWGBW-WRAPKJGWSA-N 540810 US11261211, Compound SA-106 Gamma-aminobutyric acid receptor subunit alpha-1 300 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540810 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540810&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663835 464925793 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147033 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2ncccc12 InChI=1S/C27H37N3O2/c1-26(32)11-9-18-17(14-26)5-6-20-19(18)10-12-27(2)21(20)7-8-22(27)25(31)16-30-24-4-3-13-28-23(24)15-29-30/h3-4,13,15,17-22,32H,5-12,14,16H2,1-2H3/t17-,18+,19-,20-,21+,22-,26-,27+/m1/s1 KOMBGWPXIHBMLL-GDKCFQAPSA-N 540737 US11261211, Compound SA-3 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540737 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540737&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298426 464925721 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147034 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc2CCCCc2n1 InChI=1S/C28H42N2O2/c1-27(32)13-11-20-18(15-27)7-8-22-21(20)12-14-28(2)23(22)9-10-24(28)26(31)17-30-16-19-5-3-4-6-25(19)29-30/h16,18,20-24,32H,3-15,17H2,1-2H3/t18-,20+,21-,22-,23+,24-,27-,28+/m1/s1 PDOZRVXKPBQAJH-MOYGJMECSA-N 540738 US11261211, Compound SA-7 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540738&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298007 464925722 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147035 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1ncc2CCCCc12 InChI=1S/C28H42N2O2/c1-27(32)13-11-20-18(15-27)7-8-22-21(20)12-14-28(2)23(22)9-10-24(28)26(31)17-30-25-6-4-3-5-19(25)16-29-30/h16,18,20-24,32H,3-15,17H2,1-2H3/t18-,20+,21-,22-,23+,24-,27-,28+/m1/s1 QYEIQYJLVREYBI-MOYGJMECSA-N 540739 US11261211, Compound SA-8 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540739 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540739&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298214 464925723 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147036 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc2ccccc2n1 InChI=1S/C28H38N2O2/c1-27(32)13-11-20-18(15-27)7-8-22-21(20)12-14-28(2)23(22)9-10-24(28)26(31)17-30-16-19-5-3-4-6-25(19)29-30/h3-6,16,18,20-24,32H,7-15,17H2,1-2H3/t18-,20+,21-,22-,23+,24-,27-,28+/m1/s1 LMJMBPXKXWIKQK-MOYGJMECSA-N 540740 US11261211, Compound SA-6 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540740 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540740&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117663834 464925724 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147030 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nnc2ccccc12 InChI=1S/C27H37N3O2/c1-26(32)13-11-18-17(15-26)7-8-20-19(18)12-14-27(2)21(20)9-10-22(27)25(31)16-30-24-6-4-3-5-23(24)28-29-30/h3-6,17-22,32H,7-16H2,1-2H3/t17-,18+,19-,20-,21+,22-,26-,27+/m1/s1 YSQQDSTXXNAQID-GDKCFQAPSA-N 540734 US11261211, Compound SA-1 Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540734 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540734&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86298425 464925718 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147031 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1nc2ccccc2n1 InChI=1S/C27H37N3O2/c1-26(32)13-11-18-17(15-26)7-8-20-19(18)12-14-27(2)21(20)9-10-22(27)25(31)16-30-28-23-5-3-4-6-24(23)29-30/h3-6,17-22,32H,7-16H2,1-2H3/t17-,18+,19-,20-,21+,22-,26-,27+/m1/s1 CCQLFFXLUNBTNR-GDKCFQAPSA-N 540735 US11261211, Compound SA-2 Gamma-aminobutyric acid receptor subunit alpha-1 <10 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540735 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540735&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 85470948 464925719 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1147032 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)Cn1cc2ncccc2n1 InChI=1S/C27H37N3O2/c1-26(32)11-9-18-17(14-26)5-6-20-19(18)10-12-27(2)21(20)7-8-22(27)25(31)16-30-15-24-23(29-30)4-3-13-28-24/h3-4,13,15,17-22,32H,5-12,14,16H2,1-2H3/t17-,18+,19-,20-,21+,22-,26-,27+/m1/s1 BTLWEEGNXUJKKB-GDKCFQAPSA-N 540736 US11261211, Compound SA-4 Gamma-aminobutyric acid receptor subunit alpha-1 <10 US Patent 10.7270/Q2988B61 aid1806377 US11261211 Martinez Botella, G; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therapeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=540736 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=540736&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86297807 464925720 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0 Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 51513013 Cn1c2ccc(F)cc2c2c(cn(-c3ccccc3)c(=O)c12)C(=O)N1CCCC1 InChI=1S/C23H20FN3O2/c1-25-19-10-9-15(24)13-17(19)20-18(22(28)26-11-5-6-12-26)14-27(23(29)21(20)25)16-7-3-2-4-8-16/h2-4,7-10,13-14H,5-6,11-12H2,1H3 QQWHWWDIFGNCLV-UHFFFAOYSA-N 85806 6-FLUOR-2-FENYL-9-METHYL-4-(PYRROLIDINE-1-CARBONYL)-9H-PYRIDO[3,4B]INDOOL-1(2H)-ON::CAS_205881-86-3::SL651498 Gamma-aminobutyric acid receptor subunit alpha-1 7.0 ChEMBL 10.7270/Q2GF0ZQF 33528252 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=85806 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=85806&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 9908378 136351906 ZINC00602639 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383397 CC(=O)N1CCN(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)CC1 InChI=1S/C27H44N2O3/c1-18(30)29-14-12-28(13-15-29)17-25(31)24-7-6-23-22-5-4-19-16-26(2,32)10-8-20(19)21(22)9-11-27(23,24)3/h19-24,32H,4-17H2,1-3H3/t19-,20+,21-,22-,23+,24-,26-,27+/m1/s1 QKBGEPDGEYEZOJ-YTKMTPDTSA-N 655555 US11912737, Example 1. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655555&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662175 496174640 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383398 CN1CCN(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)CC1 InChI=1S/C26H44N2O2/c1-25(30)10-8-19-18(16-25)4-5-21-20(19)9-11-26(2)22(21)6-7-23(26)24(29)17-28-14-12-27(3)13-15-28/h18-23,30H,4-17H2,1-3H3/t18-,19+,20-,21-,22+,23-,25-,26+/m1/s1 ZHJSVBBWPQNLGQ-VUYLISRKSA-N 655556 US11912737, Example 2. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655556&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662198 496174641 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383399 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCC(O)CC1 InChI=1S/C26H43NO3/c1-25(30)11-7-19-17(15-25)3-4-21-20(19)8-12-26(2)22(21)5-6-23(26)24(29)16-27-13-9-18(28)10-14-27/h17-23,28,30H,3-16H2,1-2H3/t17-,19+,20-,21-,22+,23-,25-,26+/m1/s1 CQCCPYXHJHHFKH-HRUCLDKUSA-N 655557 US11912737, Example 3. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655557&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662223 496174642 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383400 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCC(O)C1 InChI=1S/C25H41NO3/c1-24(29)10-7-18-16(13-24)3-4-20-19(18)8-11-25(2)21(20)5-6-22(25)23(28)15-26-12-9-17(27)14-26/h16-22,27,29H,3-15H2,1-2H3/t16-,17?,18+,19-,20-,21+,22-,24-,25+/m1/s1 CCCFAGDMSHECMB-JJKDOGIASA-N 655558 US11912737, Example 4. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655558&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662199 496174643 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383401 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CC(O)C1 InChI=1S/C24H39NO3/c1-23(28)9-7-17-15(11-23)3-4-19-18(17)8-10-24(2)20(19)5-6-21(24)22(27)14-25-12-16(26)13-25/h15-21,26,28H,3-14H2,1-2H3/t15-,17+,18-,19-,20+,21-,23-,24+/m1/s1 FDIWVLQLMQTMHM-UZNJFETESA-N 655559 US11912737, Example 5. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655559&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662151 496174644 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383402 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCCC(O)C1 InChI=1S/C26H43NO3/c1-25(30)11-9-19-17(14-25)5-6-21-20(19)10-12-26(2)22(21)7-8-23(26)24(29)16-27-13-3-4-18(28)15-27/h17-23,28,30H,3-16H2,1-2H3/t17-,18?,19+,20-,21-,22+,23-,25-,26+/m1/s1 BRSTVIBEBIMACI-FNOSVFLFSA-N 655560 US11912737, Example 6. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655560&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662176 496174645 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383403 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCN(CC1)S(C)(=O)=O InChI=1S/C26H44N2O4S/c1-25(30)10-8-19-18(16-25)4-5-21-20(19)9-11-26(2)22(21)6-7-23(26)24(29)17-27-12-14-28(15-13-27)33(3,31)32/h18-23,30H,4-17H2,1-3H3/t18-,19+,20-,21-,22+,23-,25-,26+/m1/s1 GPTJUJVKDNTTKY-VUYLISRKSA-N 655561 US11912737, Example 1::US11912737, Example 7. Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655561&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662177 496174646 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383404 CNC(=O)N1CCN(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)CC1 InChI=1S/C27H45N3O3/c1-26(33)10-8-19-18(16-26)4-5-21-20(19)9-11-27(2)22(21)6-7-23(27)24(31)17-29-12-14-30(15-13-29)25(32)28-3/h18-23,33H,4-17H2,1-3H3,(H,28,32)/t18-,19+,20-,21-,22+,23-,26-,27+/m1/s1 YVGPHQOBTCDQIF-KBPGHLADSA-N 655562 US11912737, Example 8. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655562&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662158 496174647 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383405 CCCN1CCN(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)CC1 InChI=1S/C28H48N2O2/c1-4-13-29-14-16-30(17-15-29)19-26(31)25-8-7-24-23-6-5-20-18-27(2,32)11-9-21(20)22(23)10-12-28(24,25)3/h20-25,32H,4-19H2,1-3H3/t20-,21+,22-,23-,24+,25-,27-,28+/m1/s1 YDDNPFVTVGLLIM-IFVJMSKTSA-N 655563 US11912737, Example 9. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655563&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662200 496174648 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383406 C[C@@H]1CN(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)CCO1 InChI=1S/C26H43NO3/c1-17-15-27(12-13-30-17)16-24(28)23-7-6-22-21-5-4-18-14-25(2,29)10-8-19(18)20(21)9-11-26(22,23)3/h17-23,29H,4-16H2,1-3H3/t17-,18-,19+,20-,21-,22+,23-,25-,26+/m1/s1 RLCZZQJPXWTEGR-WZBLJUMOSA-N 655564 US11912737, Example 10.::US11912737, Example 2 Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655564&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662153 496174649 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383407 C[C@@H]1COCCN1CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@](C)(O)CC[C@@H]4[C@H]3CC[C@]12C InChI=1S/C26H43NO3/c1-17-16-30-13-12-27(17)15-24(28)23-7-6-22-21-5-4-18-14-25(2,29)10-8-19(18)20(21)9-11-26(22,23)3/h17-23,29H,4-16H2,1-3H3/t17-,18-,19+,20-,21-,22+,23-,25-,26+/m1/s1 HWTSYZCYQKREFN-WZBLJUMOSA-N 655565 US11912737, Example 11.::US11912737, Example 3 Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655565&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662152 496174650 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383408 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCC(O)CC1 InChI=1S/C26H43NO3/c1-25(30)11-7-19-17(15-25)3-4-21-20(19)8-12-26(2)22(21)5-6-23(26)24(29)16-27-13-9-18(28)10-14-27/h17-23,28,30H,3-16H2,1-2H3/t17-,19-,20+,21+,22-,23+,25+,26-/m0/s1 CQCCPYXHJHHFKH-OPPIBPMMSA-N 655566 US11912737, Example 12. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655566&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86302853 496174651 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383409 CC(=O)N1CCN(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)CC1 InChI=1S/C27H44N2O3/c1-18(30)29-14-12-28(13-15-29)17-25(31)24-7-6-23-22-5-4-19-16-26(2,32)10-8-20(19)21(22)9-11-27(23,24)3/h19-24,32H,4-17H2,1-3H3/t19-,20-,21+,22+,23-,24+,26+,27-/m0/s1 QKBGEPDGEYEZOJ-GHTFCBLCSA-N 655567 US11912737, Example 13. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655567&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303014 496174652 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383410 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCCC(O)C1 InChI=1S/C26H43NO3/c1-25(30)11-9-19-17(14-25)5-6-21-20(19)10-12-26(2)22(21)7-8-23(26)24(29)16-27-13-3-4-18(28)15-27/h17-23,28,30H,3-16H2,1-2H3/t17-,18?,19-,20+,21+,22-,23+,25+,26-/m0/s1 BRSTVIBEBIMACI-WTHDCUHVSA-N 655568 US11912737, Example 15. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655568&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303017 496174653 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383411 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCC(O)C1 InChI=1S/C25H41NO3/c1-24(29)10-7-18-16(13-24)3-4-20-19(18)8-11-25(2)21(20)5-6-22(25)23(28)15-26-12-9-17(27)14-26/h16-22,27,29H,3-15H2,1-2H3/t16-,17?,18-,19+,20+,21-,22+,24+,25-/m0/s1 CCCFAGDMSHECMB-DKGBBCPESA-N 655569 US11912737, Example 17. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655569&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86302856 496174654 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383412 C[C@H]1C[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC[C@H]23)C[C@]1(C)O InChI=1S/C26H43NO3/c1-17-14-21-18(15-26(17,3)29)4-5-20-19(21)8-9-25(2)22(20)6-7-23(25)24(28)16-27-10-12-30-13-11-27/h17-23,29H,4-16H2,1-3H3/t17-,18-,19-,20+,21-,22-,23+,25-,26-/m0/s1 DAMYQHLOGLDQGT-XBZDJMKTSA-N 655570 US11912737, Example 18. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655570&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86302689 496174655 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383413 CC(=O)N1CCN(CC(=O)[C@H]2CC[C@H]3[C@@H]4C[C@@H](F)[C@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)CC1 InChI=1S/C27H43FN2O3/c1-17(31)30-12-10-29(11-13-30)16-25(32)23-5-4-22-20-14-24(28)21-15-26(2,33)8-6-19(21)18(20)7-9-27(22,23)3/h18-24,33H,4-16H2,1-3H3/t18-,19-,20-,21+,22+,23-,24-,26-,27+/m1/s1 NUPZJKXRKZPXLD-UMOXUQGYSA-N 655571 US11912737, Example 19. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655571&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303180 496174656 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383414 C[C@@H]1C[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCN(CC5)C(C)=O)[C@@]4(C)CC[C@H]23)C[C@]1(C)O InChI=1S/C28H46N2O3/c1-18-15-23-20(16-28(18,4)33)5-6-22-21(23)9-10-27(3)24(22)7-8-25(27)26(32)17-29-11-13-30(14-12-29)19(2)31/h18,20-25,33H,5-17H2,1-4H3/t18-,20+,21+,22-,23+,24+,25-,27+,28+/m1/s1 FUFQTHGZNLBKTQ-AVPUZBKSSA-N 655572 US11912737, Example 20. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655572&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662159 496174657 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383415 C[C@H]1C[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCN(CC5)C(C)=O)[C@@]4(C)CC[C@H]23)C[C@]1(C)O InChI=1S/C28H46N2O3/c1-18-15-23-20(16-28(18,4)33)5-6-22-21(23)9-10-27(3)24(22)7-8-25(27)26(32)17-29-11-13-30(14-12-29)19(2)31/h18,20-25,33H,5-17H2,1-4H3/t18-,20-,21-,22+,23-,24-,25+,27-,28-/m0/s1 FUFQTHGZNLBKTQ-RKMKVHLTSA-N 655573 US11912737, Example 21. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655573&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86302854 496174658 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383416 COC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCN(CC5)S(C)(=O)=O)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C27H46N2O5S/c1-26-10-8-21-20-9-11-27(31,18-34-2)16-19(20)4-5-22(21)23(26)6-7-24(26)25(30)17-28-12-14-29(15-13-28)35(3,32)33/h19-24,31H,4-18H2,1-3H3/t19-,20+,21-,22-,23+,24-,26+,27-/m1/s1 SISBHGIXHBGVHI-XFTSTIFJSA-N 655574 US11912737, Example 22. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655574&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662157 496174659 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383417 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCNCC1 InChI=1S/C25H42N2O2/c1-24(29)9-7-18-17(15-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(28)16-27-13-11-26-12-14-27/h17-22,26,29H,3-16H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1 GVGVFOPZJSVOPI-GVKWWOCJSA-N 655575 US11912737, Example 23.::US11912737, Example 51. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655575&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662230 496174660 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383418 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCNCC1 InChI=1S/C25H42N2O2/c1-24(29)9-7-18-17(15-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(28)16-27-13-11-26-12-14-27/h17-22,26,29H,3-16H2,1-2H3/t17-,18-,19+,20+,21-,22+,24+,25-/m0/s1 GVGVFOPZJSVOPI-XIYCRCSWSA-N 655576 US11912737, Example 24. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655576&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303018 496174661 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383419 C[C@@H]1C[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCN(CC5)S(C)(=O)=O)[C@@]4(C)CC[C@H]23)C[C@]1(C)O InChI=1S/C27H46N2O4S/c1-18-15-22-19(16-27(18,3)31)5-6-21-20(22)9-10-26(2)23(21)7-8-24(26)25(30)17-28-11-13-29(14-12-28)34(4,32)33/h18-24,31H,5-17H2,1-4H3/t18-,19+,20+,21-,22+,23+,24-,26+,27+/m1/s1 RCXKKMQZVMBARW-JFNCNDIJSA-N 655577 US11912737, Example 25. Gamma-aminobutyric acid receptor subunit alpha-1 75 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655577&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303181 496174662 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383420 C[C@]12CC[C@H]3[C@@H](C[C@@H](F)[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCN(CC1)S(C)(=O)=O InChI=1S/C26H43FN2O4S/c1-25(31)8-6-18-17-7-9-26(2)21(19(17)14-23(27)20(18)15-25)4-5-22(26)24(30)16-28-10-12-29(13-11-28)34(3,32)33/h17-23,31H,4-16H2,1-3H3/t17-,18-,19-,20-,21+,22-,23-,25-,26+/m1/s1 GHNONVJDUNDSPU-ZUWXLWBDSA-N 655578 US11912737, Example 26. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655578&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662209 496174663 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383421 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCN(CC1)S(C)(=O)=O InChI=1S/C26H43FN2O4S/c1-25-9-7-20-19-8-10-26(31,17-27)15-18(19)3-4-21(20)22(25)5-6-23(25)24(30)16-28-11-13-29(14-12-28)34(2,32)33/h18-23,31H,3-17H2,1-2H3/t18-,19+,20-,21-,22+,23-,25+,26-/m1/s1 VJTYHLCLJRGPDJ-HXKXIXNFSA-N 655579 US11912737, Example 27. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655579&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662160 496174664 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383422 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCN(CC1)S(C)(=O)=O InChI=1S/C26H43FN2O4S/c1-25-9-7-20-19-8-10-26(31,17-27)15-18(19)3-4-21(20)22(25)5-6-23(25)24(30)16-28-11-13-29(14-12-28)34(2,32)33/h18-23,31H,3-17H2,1-2H3/t18-,19-,20+,21+,22-,23+,25-,26+/m0/s1 VJTYHLCLJRGPDJ-ZGTMQHHXSA-N 655580 US11912737, Example 28.::US11912737, Example 35. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655580&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303336 496174665 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383423 C[C@H]1CN(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)C[C@H](C)O1 InChI=1S/C27H45NO3/c1-17-14-28(15-18(2)31-17)16-25(29)24-8-7-23-22-6-5-19-13-26(3,30)11-9-20(19)21(22)10-12-27(23,24)4/h17-24,30H,5-16H2,1-4H3/t17-,18-,19+,20-,21+,22+,23-,24+,26+,27-/m0/s1 BHWHXERXMNTYCY-USQNUIRHSA-N 655581 US11912737, Example 31. Gamma-aminobutyric acid receptor subunit alpha-1 30 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655581&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 85470961 496174666 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383424 C[C@@H]1CCN(CC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@@H]5C[C@](C)(O)CC[C@@H]5[C@H]4CC[C@]23C)C1 InChI=1S/C26H43NO2/c1-17-10-13-27(15-17)16-24(28)23-7-6-22-21-5-4-18-14-25(2,29)11-8-19(18)20(21)9-12-26(22,23)3/h17-23,29H,4-16H2,1-3H3/t17-,18-,19+,20-,21-,22+,23-,25-,26+/m1/s1 UBSLVVWYKRKYIK-WZBLJUMOSA-N 655582 US11912737, Example 32. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655582&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662224 496174667 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383425 CC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCN(CC5)S(C)(=O)=O)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C27H46N2O4S/c1-4-27(31)12-10-20-19(17-27)5-6-22-21(20)9-11-26(2)23(22)7-8-24(26)25(30)18-28-13-15-29(16-14-28)34(3,32)33/h19-24,31H,4-18H2,1-3H3/t19-,20-,21+,22+,23-,24+,26-,27+/m0/s1 XNIWPHBUHLLOBH-URDRGLOHSA-N 655583 US11912737, Example 33. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655583&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303183 496174668 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383426 CCOC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCN(CC5)S(C)(=O)=O)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C28H48N2O5S/c1-4-35-19-28(32)12-10-21-20(17-28)5-6-23-22(21)9-11-27(2)24(23)7-8-25(27)26(31)18-29-13-15-30(16-14-29)36(3,33)34/h20-25,32H,4-19H2,1-3H3/t20-,21-,22+,23+,24-,25+,27-,28+/m0/s1 IMMBAYNLZLWEBC-YSLAPMGRSA-N 655584 US11912737, Example 34. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655584&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303338 496174669 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383427 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCN(CC1)S(C)(=O)=O InChI=1S/C26H43FN2O4S/c1-25-9-7-20-19-8-10-26(31,17-27)15-18(19)3-4-21(20)22(25)5-6-23(25)24(30)16-28-11-13-29(14-12-28)34(2,32)33/h18-23,31H,3-17H2,1-2H3/t18-,19-,20+,21+,22-,23+,25-,26+/m0/s1 VJTYHLCLJRGPDJ-ZGTMQHHXSA-N 655580 US11912737, Example 28.::US11912737, Example 35. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655580&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303336 496174665 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383428 CC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCN(CC5)S(C)(=O)=O)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C27H46N2O4S/c1-4-27(31)12-10-20-19(17-27)5-6-22-21(20)9-11-26(2)23(22)7-8-24(26)25(30)18-28-13-15-29(16-14-28)34(3,32)33/h19-24,31H,4-18H2,1-3H3/t19-,20+,21-,22-,23+,24-,26+,27-/m1/s1 XNIWPHBUHLLOBH-XFTSTIFJSA-N 655586 US11912737, Example 36. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655586&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662234 496174670 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383429 C[C@@H]1CCCCN1CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@](C)(O)CC[C@@H]4[C@H]3CC[C@]12C InChI=1S/C27H45NO2/c1-18-6-4-5-15-28(18)17-25(29)24-10-9-23-22-8-7-19-16-26(2,30)13-11-20(19)21(22)12-14-27(23,24)3/h18-24,30H,4-17H2,1-3H3/t18-,19-,20+,21-,22-,23+,24-,26-,27+/m1/s1 PWFDGLFRVZPVLE-ZSXHFZOPSA-N 655587 US11912737, Example 37. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655587&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662161 496174671 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383430 C[C@]12CC[C@H]3[C@@H](C[C@@H](F)[C@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCOCC1 InChI=1S/C25H40FNO3/c1-24(29)7-5-17-16-6-8-25(2)20(18(16)13-22(26)19(17)14-24)3-4-21(25)23(28)15-27-9-11-30-12-10-27/h16-22,29H,3-15H2,1-2H3/t16-,17-,18-,19+,20+,21-,22-,24-,25+/m1/s1 FBLPYRHEJZEWRQ-QXDALCNMSA-N 655588 US11912737, Example 38. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655588&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303339 496174672 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383431 C[C@@H]1C[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC[C@H]23)C[C@]1(C)O InChI=1S/C26H43NO3/c1-17-14-21-18(15-26(17,3)29)4-5-20-19(21)8-9-25(2)22(20)6-7-23(25)24(28)16-27-10-12-30-13-11-27/h17-23,29H,4-16H2,1-3H3/t17-,18+,19+,20-,21+,22+,23-,25+,26+/m1/s1 DAMYQHLOGLDQGT-QEBWINDWSA-N 655589 US11912737, Example 39. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655589&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662207 496174673 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383432 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](O)(CC[C@H]34)C(F)F)[C@@H]1CC[C@@H]2C(=O)CN1CCOCC1 InChI=1S/C25H39F2NO3/c1-24-8-6-18-17-7-9-25(30,23(26)27)14-16(17)2-3-19(18)20(24)4-5-21(24)22(29)15-28-10-12-31-13-11-28/h16-21,23,30H,2-15H2,1H3/t16-,17+,18-,19-,20+,21-,24+,25-/m1/s1 LNTCAKAJQIQPNY-WVPFUGAFSA-N 655590 US11912737, Example 40. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655590&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662172 496174674 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383433 CO[C@H]1C[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC[C@H]23)C[C@]1(C)O InChI=1S/C26H43NO4/c1-25-9-8-18-19(5-4-17-15-26(2,29)24(30-3)14-20(17)18)21(25)6-7-22(25)23(28)16-27-10-12-31-13-11-27/h17-22,24,29H,4-16H2,1-3H3/t17-,18-,19+,20-,21-,22+,24-,25-,26-/m0/s1 KONXRHFDICYJQE-GELILGFASA-N 655591 US11912737, Example 41. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655591&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303637 496174675 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383434 COC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C26H43NO4/c1-25-9-7-20-19-8-10-26(29,17-30-2)15-18(19)3-4-21(20)22(25)5-6-23(25)24(28)16-27-11-13-31-14-12-27/h18-23,29H,3-17H2,1-2H3/t18-,19-,20+,21+,22-,23+,25-,26+/m0/s1 HMSUZQPYZXVPFJ-ZGTMQHHXSA-N 655592 US11912737, Example 42. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655592&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303638 496174676 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383435 COC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C26H43NO4/c1-25-9-7-20-19-8-10-26(29,17-30-2)15-18(19)3-4-21(20)22(25)5-6-23(25)24(28)16-27-11-13-31-14-12-27/h18-23,29H,3-17H2,1-2H3/t18-,19+,20-,21-,22+,23-,25+,26-/m1/s1 HMSUZQPYZXVPFJ-HXKXIXNFSA-N 655593 US11912737, Example 43. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655593&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662208 496174677 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383436 C[C@]12CC[C@H]3[C@@H](C[C@@H](F)[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCOCC1 InChI=1S/C25H40FNO3/c1-24(29)7-5-17-16-6-8-25(2)20(18(16)13-22(26)19(17)14-24)3-4-21(25)23(28)15-27-9-11-30-12-10-27/h16-22,29H,3-15H2,1-2H3/t16-,17-,18-,19-,20+,21-,22-,24-,25+/m1/s1 FBLPYRHEJZEWRQ-FEDMVLORSA-N 655594 US11912737, Example 44. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655594&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662166 496174678 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383437 CCO[C@H]1C[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC[C@H]23)C[C@]1(C)O InChI=1S/C27H45NO4/c1-4-32-25-15-21-18(16-27(25,3)30)5-6-20-19(21)9-10-26(2)22(20)7-8-23(26)24(29)17-28-11-13-31-14-12-28/h18-23,25,30H,4-17H2,1-3H3/t18-,19-,20+,21-,22-,23+,25-,26-,27-/m0/s1 BBJBTXLGUQUYHK-PHGURLGZSA-N 655595 US11912737, Example 45. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655595 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655595&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303640 496174679 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383438 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCOCC1 InChI=1S/C25H40FNO3/c1-24-8-6-19-18-7-9-25(29,16-26)14-17(18)2-3-20(19)21(24)4-5-22(24)23(28)15-27-10-12-30-13-11-27/h17-22,29H,2-16H2,1H3/t17-,18+,19-,20-,21+,22-,24+,25-/m1/s1 WLRRURJMUASLFF-DCPTXXHLSA-N 655596 US11912737, Example 46. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655596 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655596&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662154 496174680 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383439 CC[C@@]1(O)CC[C@H]2[C@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C26H43NO3/c1-3-26(29)11-9-19-18(16-26)4-5-21-20(19)8-10-25(2)22(21)6-7-23(25)24(28)17-27-12-14-30-15-13-27/h18-23,29H,3-17H2,1-2H3/t18-,19+,20-,21-,22+,23-,25+,26-/m1/s1 CEZCUTNTPQPYMF-HXKXIXNFSA-N 655597 US11912737, Example 47. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655597&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662231 496174681 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383440 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@](O)(CF)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCOCC1 InChI=1S/C25H40FNO3/c1-24-8-6-19-18-7-9-25(29,16-26)14-17(18)2-3-20(19)21(24)4-5-22(24)23(28)15-27-10-12-30-13-11-27/h17-22,29H,2-16H2,1H3/t17-,18-,19+,20+,21-,22+,24-,25+/m0/s1 WLRRURJMUASLFF-KTOOMANLSA-N 655598 US11912737, Example 48. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655598&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303639 496174682 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383441 CC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C26H43NO3/c1-3-26(29)11-9-19-18(16-26)4-5-21-20(19)8-10-25(2)22(21)6-7-23(25)24(28)17-27-12-14-30-15-13-27/h18-23,29H,3-17H2,1-2H3/t18-,19-,20+,21+,22-,23+,25-,26+/m0/s1 CEZCUTNTPQPYMF-ZGTMQHHXSA-N 655599 US11912737, Example 49. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655599&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303641 496174683 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383442 CCOC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCOCC5)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C27H45NO4/c1-3-31-18-27(30)11-9-20-19(16-27)4-5-22-21(20)8-10-26(2)23(22)6-7-24(26)25(29)17-28-12-14-32-15-13-28/h19-24,30H,3-18H2,1-2H3/t19-,20-,21+,22+,23-,24+,26-,27+/m0/s1 KLZVZPVCXVKWQL-URDRGLOHSA-N 655600 US11912737, Example 50. Gamma-aminobutyric acid receptor subunit alpha-1 >500 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655600 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655600&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662293 496174684 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383443 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCNCC1 InChI=1S/C25H42N2O2/c1-24(29)9-7-18-17(15-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(28)16-27-13-11-26-12-14-27/h17-22,26,29H,3-16H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1 GVGVFOPZJSVOPI-GVKWWOCJSA-N 655575 US11912737, Example 23.::US11912737, Example 51. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655575&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662230 496174660 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383444 COC[C@@]1(O)CC[C@H]2[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CN5CCN(CC5)S(C)(=O)=O)[C@@]4(C)CC[C@H]23)C1 InChI=1S/C27H46N2O5S/c1-26-10-8-21-20-9-11-27(31,18-34-2)16-19(20)4-5-22(21)23(26)6-7-24(26)25(30)17-28-12-14-29(15-13-28)35(3,32)33/h19-24,31H,4-18H2,1-3H3/t19-,20-,21+,22+,23-,24+,26-,27+/m0/s1 SISBHGIXHBGVHI-URDRGLOHSA-N 655602 US11912737, Example 52. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655602&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 86303335 496174685 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4 1383445 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@](C)(O)CC[C@H]34)[C@@H]1CC[C@@H]2C(=O)CN1CCCOCC1 InChI=1S/C26H43NO3/c1-25(29)10-8-19-18(16-25)4-5-21-20(19)9-11-26(2)22(21)6-7-23(26)24(28)17-27-12-3-14-30-15-13-27/h18-23,29H,3-17H2,1-2H3/t18-,19+,20-,21-,22+,23-,25-,26+/m1/s1 YVRWCOGKMNYLEC-VUYLISRKSA-N 655603 US11912737, Example 53. Gamma-aminobutyric acid receptor subunit alpha-1 >100 US Patent 10.7270/Q26977VB US11912737 Botella, GM; Harrison, BL; Robichaud, AJ; Salituro, FG; Beresis, RT Sage Therpeutics, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=655603 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10421&target=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=655603&enzyme=Gamma-aminobutyric+acid+receptor+subunit+alpha-1&column=ki&startPg=0&Increment=50&submit=Search 117662201 496174686 1 MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ 6DW0,6DW1,7PBD,7PBZ,7PC0,8FOI,8G4N,8G4O,8G4X,8G5F,8G5G,8G5H Gamma-aminobutyric acid receptor subunit alpha-1 GBRA1_RAT P62813 P18504 Q53YK4