BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID of Ligand PubChem SID of Ligand ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 414067 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCCCC1 InChI=1S/C30H34BrN3O4/c1-19(32-2)28(35)33-27-29(36)34(18-23-22-13-12-21(31)17-20(22)11-14-25(23)37-3)24-9-5-6-10-26(24)38-30(27)15-7-4-8-16-30/h5-6,9-14,17,19,27,32H,4,7-8,15-16,18H2,1-3H3,(H,33,35)/t19-,27+/m0/s1 NPXQPTQRHDMBAF-UZTOHYMASA-N 237555 US9394263, 1 E3 ubiquitin-protein ligase XIAP [124-240] 880 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237555 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237555&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73056304 340131025 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414068 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC1(C)C InChI=1S/C27H30BrN3O4/c1-16(29-4)25(32)30-24-26(33)31(21-8-6-7-9-23(21)35-27(24,2)3)15-20-19-12-11-18(28)14-17(19)10-13-22(20)34-5/h6-14,16,24,29H,15H2,1-5H3,(H,30,32)/t16-,24+/m0/s1 AIFKERXJRHIYEU-UPCLLVRISA-N 237556 US9394263, 1a E3 ubiquitin-protein ligase XIAP [124-240] 152 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237556 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237556&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586169 340131026 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414069 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCNCC1 InChI=1S/C29H33BrN4O4/c1-18(31-2)27(35)33-26-28(36)34(17-22-21-10-9-20(30)16-19(21)8-11-24(22)37-3)23-6-4-5-7-25(23)38-29(26)12-14-32-15-13-29/h4-11,16,18,26,31-32H,12-15,17H2,1-3H3,(H,33,35)/t18-,26+/m0/s1 LLTJNOCLVXIVKU-HFJWLAOPSA-N 237557 US9394263, 1b E3 ubiquitin-protein ligase XIAP [124-240] 929 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237557 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237557&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586226 340131027 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414070 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCCC1 InChI=1S/C29H32BrN3O4/c1-18(31-2)27(34)32-26-28(35)33(23-8-4-5-9-25(23)37-29(26)14-6-7-15-29)17-22-21-12-11-20(30)16-19(21)10-13-24(22)36-3/h4-5,8-13,16,18,26,31H,6-7,14-15,17H2,1-3H3,(H,32,34)/t18-,26+/m0/s1 UIEQCWRMMZYHBP-HFJWLAOPSA-N 237558 US9394263, 1c E3 ubiquitin-protein ligase XIAP [124-240] 193 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237558 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237558&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586161 340131028 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414071 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCN(CC1)S(C)(=O)=O InChI=1S/C30H35BrN4O6S/c1-19(32-2)28(36)33-27-29(37)35(18-23-22-11-10-21(31)17-20(22)9-12-25(23)40-3)24-7-5-6-8-26(24)41-30(27)13-15-34(16-14-30)42(4,38)39/h5-12,17,19,27,32H,13-16,18H2,1-4H3,(H,33,36)/t19-,27+/m0/s1 GQYKSKANNOJUJD-UZTOHYMASA-N 237559 US9394263, 1d E3 ubiquitin-protein ligase XIAP [124-240] 301 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237559 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237559&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586227 340131029 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414072 CN[C@@H](C)C(=O)N[C@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCN(CC1)S(C)(=O)=O InChI=1S/C30H35BrN4O6S/c1-19(32-2)28(36)33-27-29(37)35(18-23-22-11-10-21(31)17-20(22)9-12-25(23)40-3)24-7-5-6-8-26(24)41-30(27)13-15-34(16-14-30)42(4,38)39/h5-12,17,19,27,32H,13-16,18H2,1-4H3,(H,33,36)/t19-,27-/m0/s1 GQYKSKANNOJUJD-PPHZAIPVSA-N 237560 US9394263, 1e E3 ubiquitin-protein ligase XIAP [124-240] 6051 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237560 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237560&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586228 340131030 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414073 CN[C@@H](C)C(=O)N[C@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCOCC1 InChI=1S/C29H32BrN3O5/c1-18(31-2)27(34)32-26-28(35)33(17-22-21-10-9-20(30)16-19(21)8-11-24(22)36-3)23-6-4-5-7-25(23)38-29(26)12-14-37-15-13-29/h4-11,16,18,26,31H,12-15,17H2,1-3H3,(H,32,34)/t18-,26-/m0/s1 VUTQKGLPLFESJM-QYBDOPJKSA-N 237561 US9394263, 1f E3 ubiquitin-protein ligase XIAP [124-240] 4362 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237561 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237561&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586164 340131031 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414074 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCOCC1 InChI=1S/C29H32BrN3O5/c1-18(31-2)27(34)32-26-28(35)33(17-22-21-10-9-20(30)16-19(21)8-11-24(22)36-3)23-6-4-5-7-25(23)38-29(26)12-14-37-15-13-29/h4-11,16,18,26,31H,12-15,17H2,1-3H3,(H,32,34)/t18-,26+/m0/s1 VUTQKGLPLFESJM-HFJWLAOPSA-N 50441341 CHEMBL2431766::US9394263, 1g E3 ubiquitin-protein ligase XIAP [124-240] 65 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50441341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50441341&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 72712969 175453658 CHEMBL2431766 ZINC96285027 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414075 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11COC1 InChI=1S/C27H28BrN3O5/c1-16(29-2)25(32)30-24-26(33)31(21-6-4-5-7-23(21)36-27(24)14-35-15-27)13-20-19-10-9-18(28)12-17(19)8-11-22(20)34-3/h4-12,16,24,29H,13-15H2,1-3H3,(H,30,32)/t16-,24+/m0/s1 LOWUBHSNTBEJBT-UPCLLVRISA-N 237562 US9394263, 1h E3 ubiquitin-protein ligase XIAP [124-240] 57 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237562 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237562&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586088 340131032 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414076 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC1(C)CSC InChI=1S/C28H32BrN3O4S/c1-17(30-3)26(33)31-25-27(34)32(22-8-6-7-9-24(22)36-28(25,2)16-37-5)15-21-20-12-11-19(29)14-18(20)10-13-23(21)35-4/h6-14,17,25,30H,15-16H2,1-5H3,(H,31,33)/t17-,25+,28?/m0/s1 OXAUMKDDACUXNV-YCMCFSNUSA-N 237563 US9394263, 1i E3 ubiquitin-protein ligase XIAP [124-240] 54 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237563 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237563&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586089 340131033 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414077 CN[C@@H](C)C(=O)NC1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCCOC1 InChI=1S/C29H32BrN3O5/c1-18(31-2)27(34)32-26-28(35)33(16-22-21-11-10-20(30)15-19(21)9-12-24(22)36-3)23-7-4-5-8-25(23)38-29(26)13-6-14-37-17-29/h4-5,7-12,15,18,26,31H,6,13-14,16-17H2,1-3H3,(H,32,34)/t18-,26?,29?/m0/s1 MXKORMGTKSSRHB-RNWKXWIMSA-N 237564 US9394263, 1j E3 ubiquitin-protein ligase XIAP [124-240] 56 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237564 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237564&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586165 340131034 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414078 CN[C@@H](C)C(=O)N[C@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11COC1 InChI=1S/C27H28BrN3O5/c1-16(29-2)25(32)30-24-26(33)31(21-6-4-5-7-23(21)36-27(24)14-35-15-27)13-20-19-10-9-18(28)12-17(19)8-11-22(20)34-3/h4-12,16,24,29H,13-15H2,1-3H3,(H,30,32)/t16-,24-/m0/s1 LOWUBHSNTBEJBT-FYSMJZIKSA-N 237565 US9394263, 1k E3 ubiquitin-protein ligase XIAP [124-240] 2039 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237565 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237565&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586124 340131035 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414079 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2O[C@@]1(C)COC InChI=1S/C28H32BrN3O5/c1-17(30-3)26(33)31-25-27(34)32(22-8-6-7-9-24(22)37-28(25,2)16-35-4)15-21-20-12-11-19(29)14-18(20)10-13-23(21)36-5/h6-14,17,25,30H,15-16H2,1-5H3,(H,31,33)/t17-,25+,28-/m0/s1 QZAXSBDPPGLMSO-VFQAHANWSA-N 237566 US9394263, 1L E3 ubiquitin-protein ligase XIAP [124-240] 42 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237566 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237566&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586167 340131036 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414080 CN[C@@H](C)C(=O)NC1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC1(C)CCOC InChI=1S/C29H34BrN3O5/c1-18(31-3)27(34)32-26-28(35)33(23-8-6-7-9-25(23)38-29(26,2)14-15-36-4)17-22-21-12-11-20(30)16-19(21)10-13-24(22)37-5/h6-13,16,18,26,31H,14-15,17H2,1-5H3,(H,32,34)/t18-,26?,29?/m0/s1 HUFPMPYJYWCFTH-RNWKXWIMSA-N 237567 US9394263, 1m E3 ubiquitin-protein ligase XIAP [124-240] 345 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237567 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237567&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586166 340131037 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414081 CC[C@H](N)C(=O)NC1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCCOC1 InChI=1S/C29H32BrN3O5/c1-3-22(31)27(34)32-26-28(35)33(16-21-20-11-10-19(30)15-18(20)9-12-24(21)36-2)23-7-4-5-8-25(23)38-29(26)13-6-14-37-17-29/h4-5,7-12,15,22,26H,3,6,13-14,16-17,31H2,1-2H3,(H,32,34)/t22-,26?,29?/m0/s1 TWUWLZYRYNXASN-ZVFZUAJQSA-N 237568 US9394263, 1n E3 ubiquitin-protein ligase XIAP [124-240] 70 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237568 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237568&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118582221 340131038 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414082 COc1ccc2cc(Br)ccc2c1CN1c2ccccc2OC2(CCOCC2)[C@H](NC(=O)[C@@H](N)[C@H](C)O)C1=O InChI=1S/C29H32BrN3O6/c1-17(34)25(31)27(35)32-26-28(36)33(16-21-20-9-8-19(30)15-18(20)7-10-23(21)37-2)22-5-3-4-6-24(22)39-29(26)11-13-38-14-12-29/h3-10,15,17,25-26,34H,11-14,16,31H2,1-2H3,(H,32,35)/t17-,25-,26+/m0/s1 BVCJBHZLEXKSFD-CQEOPILBSA-N 237569 US9394263, 1o E3 ubiquitin-protein ligase XIAP [124-240] 54 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237569 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237569&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118582222 340131039 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414083 COc1ccc2cc(Br)ccc2c1CN1c2ccccc2OC2(CCOCC2)[C@@H](NC(=O)[C@@H](N)[C@H](C)O)C1=O InChI=1S/C29H32BrN3O6/c1-17(34)25(31)27(35)32-26-28(36)33(16-21-20-9-8-19(30)15-18(20)7-10-23(21)37-2)22-5-3-4-6-24(22)39-29(26)11-13-38-14-12-29/h3-10,15,17,25-26,34H,11-14,16,31H2,1-2H3,(H,32,35)/t17-,25-,26-/m0/s1 BVCJBHZLEXKSFD-ODKGLIOUSA-N 237570 US9394263, 1p E3 ubiquitin-protein ligase XIAP [124-240] 932 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237570 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237570&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118582223 340131040 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414084 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(C)ccc3ccccc23)c2ccccc2OC11CCOCC1 InChI=1S/C29H33N3O4/c1-19-12-13-21-8-4-5-9-22(21)23(19)18-32-24-10-6-7-11-25(24)36-29(14-16-35-17-15-29)26(28(32)34)31-27(33)20(2)30-3/h4-13,20,26,30H,14-18H2,1-3H3,(H,31,33)/t20-,26+/m0/s1 VXFXZFWOSDPFED-RXFWQSSRSA-N 50441340 CHEMBL2431767::US9394263, 1q E3 ubiquitin-protein ligase XIAP [124-240] 634 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50441340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50441340&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 72712971 175453657 CHEMBL2431767 ZINC96285026 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414085 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)cnc3ccccc23)c2ccccc2OC11CCOCC1 InChI=1S/C28H32N4O5/c1-18(29-2)26(33)31-25-27(34)32(17-20-19-8-4-5-9-21(19)30-16-24(20)35-3)22-10-6-7-11-23(22)37-28(25)12-14-36-15-13-28/h4-11,16,18,25,29H,12-15,17H2,1-3H3,(H,31,33)/t18-,25+/m0/s1 PCTAPXHACYCSMY-AVRWGWEMSA-N 50441337 CHEMBL2431752::US9394263, 1r E3 ubiquitin-protein ligase XIAP [124-240] 141 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50441337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50441337&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 72713167 175453654 CHEMBL2431752 ZINC96285023 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414086 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2ccnc3ccccc23)c2ccccc2OC11CCOCC1 InChI=1S/C27H30N4O4/c1-18(28-2)25(32)30-24-26(33)31(17-19-11-14-29-21-8-4-3-7-20(19)21)22-9-5-6-10-23(22)35-27(24)12-15-34-16-13-27/h3-11,14,18,24,28H,12-13,15-17H2,1-2H3,(H,30,32)/t18-,24+/m0/s1 BVOIOXPROUZGOP-MHECFPHRSA-N 237571 US9394263, 1s E3 ubiquitin-protein ligase XIAP [124-240] 965 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237571 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237571&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90036933 340131041 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414087 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2cccc3ncccc23)c2ccccc2OC11CCOCC1 InChI=1S/C27H30N4O4/c1-18(28-2)25(32)30-24-26(33)31(17-19-7-5-9-21-20(19)8-6-14-29-21)22-10-3-4-11-23(22)35-27(24)12-15-34-16-13-27/h3-11,14,18,24,28H,12-13,15-17H2,1-2H3,(H,30,32)/t18-,24+/m0/s1 WDWMVEXKPQRARH-MHECFPHRSA-N 237572 US9394263, 1t E3 ubiquitin-protein ligase XIAP [124-240] 665 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237572 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237572&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060625 340131042 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414088 CC(C)N1c2ccccc2OC2(CCOCC2)[C@H](NC(=O)[C@H](C)N)C1=O InChI=1S/C19H27N3O4/c1-12(2)22-14-6-4-5-7-15(14)26-19(8-10-25-11-9-19)16(18(22)24)21-17(23)13(3)20/h4-7,12-13,16H,8-11,20H2,1-3H3,(H,21,23)/t13-,16+/m0/s1 BWNMOYNIACGQFQ-XJKSGUPXSA-N 237573 US9394263, 1u E3 ubiquitin-protein ligase XIAP [124-240] 3362 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237573 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237573&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118582224 340131043 C03803 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414089 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(C(C)C)c2ccccc2OC11CCOCC1 InChI=1S/C20H29N3O4/c1-13(2)23-15-7-5-6-8-16(15)27-20(9-11-26-12-10-20)17(19(23)25)22-18(24)14(3)21-4/h5-8,13-14,17,21H,9-12H2,1-4H3,(H,22,24)/t14-,17+/m0/s1 WZDTUXLPMXNSTO-WMLDXEAASA-N 237574 US9394263, 1v E3 ubiquitin-protein ligase XIAP [124-240] 8615 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237574 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237574&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060715 340131044 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414090 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OCC(F)(F)F)ccc3ccccc23)c2ccccc2OC11CCOCC1 InChI=1S/C30H32F3N3O5/c1-19(34-2)27(37)35-26-28(38)36(23-9-5-6-10-25(23)41-29(26)13-15-39-16-14-29)17-22-21-8-4-3-7-20(21)11-12-24(22)40-18-30(31,32)33/h3-12,19,26,34H,13-18H2,1-2H3,(H,35,37)/t19-,26+/m0/s1 HIOJLABPFOUZCO-AFMDSPMNSA-N 237575 US9394263, 1w E3 ubiquitin-protein ligase XIAP [124-240] 241 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237575 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237575&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060717 340131045 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414091 CN[C@@H](C)C(=O)NC1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2OC11CCNC1 InChI=1S/C28H31BrN4O4/c1-17(30-2)26(34)32-25-27(35)33(22-6-4-5-7-24(22)37-28(25)12-13-31-16-28)15-21-20-10-9-19(29)14-18(20)8-11-23(21)36-3/h4-11,14,17,25,30-31H,12-13,15-16H2,1-3H3,(H,32,34)/t17-,25?,28?/m0/s1 SQLBMJAHKLVVEE-PXAXTTATSA-N 237576 US9394263, 1x E3 ubiquitin-protein ligase XIAP [124-240] 367 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237576 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237576&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060719 340131046 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414092 CN[C@@H](C)C(=O)N[C@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2O[C@@]11CCOC1 InChI=1S/C28H30BrN3O5/c1-17(30-2)26(33)31-25-27(34)32(22-6-4-5-7-24(22)37-28(25)12-13-36-16-28)15-21-20-10-9-19(29)14-18(20)8-11-23(21)35-3/h4-11,14,17,25,30H,12-13,15-16H2,1-3H3,(H,31,33)/t17-,25-,28+/m0/s1 HELQGTDTITZVDX-JGXREDOWSA-N 237577 US9394263, 1y E3 ubiquitin-protein ligase XIAP [124-240] 12200 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237577&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060712 340131047 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414093 CN[C@@H](C)C(=O)N[C@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2O[C@@]11CCOC1 InChI=1S/C28H30BrN3O5/c1-17(30-2)26(33)31-25-27(34)32(22-6-4-5-7-24(22)37-28(25)12-13-36-16-28)15-21-20-10-9-19(29)14-18(20)8-11-23(21)35-3/h4-11,14,17,25,30H,12-13,15-16H2,1-3H3,(H,31,33)/t17-,25-,28+/m0/s1 HELQGTDTITZVDX-JGXREDOWSA-N 237578 US9394263, 1z E3 ubiquitin-protein ligase XIAP [124-240] 20630 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237578&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060712 340131048 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414094 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2O[C@@]11CCOC1 InChI=1S/C28H30BrN3O5/c1-17(30-2)26(33)31-25-27(34)32(22-6-4-5-7-24(22)37-28(25)12-13-36-16-28)15-21-20-10-9-19(29)14-18(20)8-11-23(21)35-3/h4-11,14,17,25,30H,12-13,15-16H2,1-3H3,(H,31,33)/t17-,25+,28+/m0/s1 HELQGTDTITZVDX-VVTZZXDESA-N 237579 US9394263, 1a'::US9394263, 1b' E3 ubiquitin-protein ligase XIAP [124-240] 24 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237579&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586138 340131049 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414095 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc2O[C@@]11CCOC1 InChI=1S/C28H30BrN3O5/c1-17(30-2)26(33)31-25-27(34)32(22-6-4-5-7-24(22)37-28(25)12-13-36-16-28)15-21-20-10-9-19(29)14-18(20)8-11-23(21)35-3/h4-11,14,17,25,30H,12-13,15-16H2,1-3H3,(H,31,33)/t17-,25+,28+/m0/s1 HELQGTDTITZVDX-VVTZZXDESA-N 237579 US9394263, 1a'::US9394263, 1b' E3 ubiquitin-protein ligase XIAP [124-240] 267 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237579&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586138 340131049 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414096 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC)ccc3c(Br)cccc23)c2ccccc2OC11CCOCC1 InChI=1S/C29H32BrN3O5/c1-18(31-2)27(34)32-26-28(35)33(17-21-19-7-6-8-22(30)20(19)11-12-24(21)36-3)23-9-4-5-10-25(23)38-29(26)13-15-37-16-14-29/h4-12,18,26,31H,13-17H2,1-3H3,(H,32,34)/t18-,26+/m0/s1 DHCRJEINPCNUPE-HFJWLAOPSA-N 237581 US9394263, 1c' E3 ubiquitin-protein ligase XIAP [124-240] 86 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237581&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586141 340131050 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414097 CN[C@@H](C)C(=O)N[C@@H]1CC(Cc2c(OC)ccc3c(Br)cccc23)c2ccccc2O[C@H]1C InChI=1S/C27H31BrN2O3/c1-16(29-3)27(31)30-24-15-18(19-8-5-6-11-26(19)33-17(24)2)14-22-20-9-7-10-23(28)21(20)12-13-25(22)32-4/h5-13,16-18,24,29H,14-15H2,1-4H3,(H,30,31)/t16-,17-,18?,24+/m0/s1 MHMYSLLSJNMCBF-BQLKJTMJSA-N 237582 US9394263, 1d' E3 ubiquitin-protein ligase XIAP [124-240] 29 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237582&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586170 340131051 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414098 CN[C@@H](C)C(=O)N[C@H]1CSc2c(NC(=O)C3CCN(CC3)C(C)=O)cccc2N(Cc2cccc3ccccc23)C1 InChI=1S/C32H39N5O3S/c1-21(33-3)31(39)34-26-19-37(18-25-10-6-9-23-8-4-5-11-27(23)25)29-13-7-12-28(30(29)41-20-26)35-32(40)24-14-16-36(17-15-24)22(2)38/h4-13,21,24,26,33H,14-20H2,1-3H3,(H,34,39)(H,35,40)/t21-,26+/m0/s1 IVIIDYJRYVHAPR-HFZDXXHNSA-N 237609 US9394263, 23 E3 ubiquitin-protein ligase XIAP [124-240] 373 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237609 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237609&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586095 340131078 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414099 CN[C@@H](C)C(=O)N[C@H]1CSc2c(NC(=O)CCCC(C)=O)cccc2N(Cc2cccc3ccccc23)C1=O InChI=1S/C30H34N4O4S/c1-19(35)9-6-16-27(36)32-24-14-8-15-26-28(24)39-18-25(33-29(37)20(2)31-3)30(38)34(26)17-22-12-7-11-21-10-4-5-13-23(21)22/h4-5,7-8,10-15,20,25,31H,6,9,16-18H2,1-3H3,(H,32,36)(H,33,37)/t20-,25-/m0/s1 HVPMNTAMRQCXLQ-CPJSRVTESA-N 237610 US9394263, 24 E3 ubiquitin-protein ligase XIAP [124-240] 373 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237610&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73057825 340131079 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414100 CN[C@@H](C)C(=O)N[C@H]1CSc2c(NC(=O)c3cc(OC)c(OC)c(OC)c3)cccc2N(Cc2cccc3ccccc23)C1=O InChI=1S/C34H36N4O6S/c1-20(35-2)32(39)37-26-19-45-31-25(36-33(40)23-16-28(42-3)30(44-5)29(17-23)43-4)14-9-15-27(31)38(34(26)41)18-22-12-8-11-21-10-6-7-13-24(21)22/h6-17,20,26,35H,18-19H2,1-5H3,(H,36,40)(H,37,39)/t20-,26-/m0/s1 WBCJVQPIOWOMDT-FNZWTVRRSA-N 237611 US9394263, 25 E3 ubiquitin-protein ligase XIAP [124-240] 402 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237611&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73057823 340131080 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414101 CN[C@@H](C)C(=O)N[C@H]1CSc2c(NC(=O)CCCCC(C)=O)cccc2N(Cc2cccc3ccccc23)C1=O InChI=1S/C31H36N4O4S/c1-20(36)10-4-7-17-28(37)33-25-15-9-16-27-29(25)40-19-26(34-30(38)21(2)32-3)31(39)35(27)18-23-13-8-12-22-11-5-6-14-24(22)23/h5-6,8-9,11-16,21,26,32H,4,7,10,17-19H2,1-3H3,(H,33,37)(H,34,38)/t21-,26-/m0/s1 CAUBDIRLEDFWIT-LVXARBLLSA-N 237612 US9394263, 26 E3 ubiquitin-protein ligase XIAP [124-240] 245 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237612&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73058099 340131081 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414102 CN[C@@H](C)C(=O)N[C@H]1CSc2c(N)cccc2N(Cc2cccc3ccccc23)C1=O InChI=1S/C24H26N4O2S/c1-15(26-2)23(29)27-20-14-31-22-19(25)11-6-12-21(22)28(24(20)30)13-17-9-5-8-16-7-3-4-10-18(16)17/h3-12,15,20,26H,13-14,25H2,1-2H3,(H,27,29)/t15-,20-/m0/s1 OULGXBSFUJVITE-YWZLYKJASA-N 237613 US9394263, 27 E3 ubiquitin-protein ligase XIAP [124-240] 1403 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237613 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237613&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73058101 340131082 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414103 CN[C@@H](C)C(=O)N[C@H]1CSc2c(NC(=O)c3ccccc3)cccc2N(Cc2cccc3ccccc23)C1=O InChI=1S/C31H30N4O3S/c1-20(32-2)29(36)34-26-19-39-28-25(33-30(37)22-11-4-3-5-12-22)16-9-17-27(28)35(31(26)38)18-23-14-8-13-21-10-6-7-15-24(21)23/h3-17,20,26,32H,18-19H2,1-2H3,(H,33,37)(H,34,36)/t20-,26-/m0/s1 QRUYAIQIKGZQJC-FNZWTVRRSA-N 237614 US9394263, 28 E3 ubiquitin-protein ligase XIAP [124-240] 1424 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237614 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237614&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73058103 340131083 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414104 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C25H26BrN3O4/c1-15(27-2)24(30)28-20-14-33-23-7-5-4-6-21(23)29(25(20)31)13-19-18-10-9-17(26)12-16(18)8-11-22(19)32-3/h4-12,15,20,27H,13-14H2,1-3H3,(H,28,30)/t15-,20-/m0/s1 NYZLBAGNVDGXCG-YWZLYKJASA-N 50441342 CHEMBL2431765::US9394263, 29 E3 ubiquitin-protein ligase XIAP [124-240] 101 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50441342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50441342&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 72712771 175453659 CHEMBL2431765 ZINC96285028 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414105 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2ccc(Br)c3ccccc23)C1=O InChI=1S/C24H24BrN3O3/c1-15(26-2)23(29)27-20-14-31-22-10-6-5-9-21(22)28(24(20)30)13-16-11-12-19(25)18-8-4-3-7-17(16)18/h3-12,15,20,26H,13-14H2,1-2H3,(H,27,29)/t15-,20-/m0/s1 IHWAGHVWGIUTKB-YWZLYKJASA-N 237615 US9394263, 29a E3 ubiquitin-protein ligase XIAP [124-240] 675.5 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237615 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237615&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060659 340131084 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414106 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3ccccc23)C1=O InChI=1S/C25H27N3O4/c1-16(26-2)24(29)27-20-15-32-23-11-7-6-10-21(23)28(25(20)30)14-19-18-9-5-4-8-17(18)12-13-22(19)31-3/h4-13,16,20,26H,14-15H2,1-3H3,(H,27,29)/t16-,20-/m0/s1 AQHZJXJHQYKWPK-JXFKEZNVSA-N 237616 US9394263, 29b E3 ubiquitin-protein ligase XIAP [124-240] 198 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237616 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237616&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060661 340131085 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414107 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2ccccc2OC)C1=O InChI=1S/C21H25N3O4/c1-14(22-2)20(25)23-16-13-28-19-11-7-5-9-17(19)24(21(16)26)12-15-8-4-6-10-18(15)27-3/h4-11,14,16,22H,12-13H2,1-3H3,(H,23,25)/t14-,16-/m0/s1 PNPPXVPIZWKSJN-HOCLYGCPSA-N 237617 US9394263, 29c E3 ubiquitin-protein ligase XIAP [124-240] 5121 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237617 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237617&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060664 340131086 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414108 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(ccc23)C2CC2)C1=O InChI=1S/C28H31N3O4/c1-17(29-2)27(32)30-23-16-35-26-7-5-4-6-24(26)31(28(23)33)15-22-21-12-10-19(18-8-9-18)14-20(21)11-13-25(22)34-3/h4-7,10-14,17-18,23,29H,8-9,15-16H2,1-3H3,(H,30,32)/t17-,23-/m0/s1 PMTMIPLQJOJORB-SBUREZEXSA-N 237618 US9394263, 30 E3 ubiquitin-protein ligase XIAP [124-240] 382 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237618&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73058105 340131087 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414109 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(ccc23)C(=O)OC)C1=O InChI=1S/C27H29N3O6/c1-16(28-2)25(31)29-21-15-36-24-8-6-5-7-22(24)30(26(21)32)14-20-19-11-9-18(27(33)35-4)13-17(19)10-12-23(20)34-3/h5-13,16,21,28H,14-15H2,1-4H3,(H,29,31)/t16-,21-/m0/s1 XVRXCRGYPZBSBD-KKSFZXQISA-N 237619 US9394263, 31 E3 ubiquitin-protein ligase XIAP [124-240] 189 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237619&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73058107 340131088 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414110 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(ccc23)C(O)=O)C1=O InChI=1S/C26H27N3O6/c1-15(27-2)24(30)28-20-14-35-23-7-5-4-6-21(23)29(25(20)31)13-19-18-10-8-17(26(32)33)12-16(18)9-11-22(19)34-3/h4-12,15,20,27H,13-14H2,1-3H3,(H,28,30)(H,32,33)/t15-,20-/m0/s1 FXWNXUAVASQHNP-YWZLYKJASA-N 237620 US9394263, 32 E3 ubiquitin-protein ligase XIAP [124-240] 55 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237620 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237620&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73053728 340131089 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414111 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(ccc23)C(=O)N(C)CCO)C1=O InChI=1S/C29H34N4O6/c1-18(30-2)27(35)31-23-17-39-26-8-6-5-7-24(26)33(29(23)37)16-22-21-11-9-20(28(36)32(3)13-14-34)15-19(21)10-12-25(22)38-4/h5-12,15,18,23,30,34H,13-14,16-17H2,1-4H3,(H,31,35)/t18-,23-/m0/s1 MFDWMOLYSMLKHS-MBSDFSHPSA-N 237621 US9394263, 33 E3 ubiquitin-protein ligase XIAP [124-240] 2168 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237621&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586168 340131090 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414112 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(ccc23)C(=O)NCCC(O)=O)C1=O InChI=1S/C29H32N4O7/c1-17(30-2)27(36)32-22-16-40-25-7-5-4-6-23(25)33(29(22)38)15-21-20-10-8-19(28(37)31-13-12-26(34)35)14-18(20)9-11-24(21)39-3/h4-11,14,17,22,30H,12-13,15-16H2,1-3H3,(H,31,37)(H,32,36)(H,34,35)/t17-,22-/m0/s1 XLZZZYCPXCAWJQ-JTSKRJEESA-N 237622 US9394263, 34 E3 ubiquitin-protein ligase XIAP [124-240] 316 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237622 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237622&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586143 340131091 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414113 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(ccc23)C(=O)N(C)C)C1=O InChI=1S/C28H32N4O5/c1-17(29-2)26(33)30-22-16-37-25-9-7-6-8-23(25)32(28(22)35)15-21-20-12-10-19(27(34)31(3)4)14-18(20)11-13-24(21)36-5/h6-14,17,22,29H,15-16H2,1-5H3,(H,30,33)/t17-,22-/m0/s1 XIAPFVQCGJJDLL-JTSKRJEESA-N 237623 US9394263, 35 E3 ubiquitin-protein ligase XIAP [124-240] 2290 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237623 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237623&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060696 340131092 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414114 CN[C@@H](C)C(=O)N[C@H]1COc2cc(C)ccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C26H28BrN3O4/c1-15-5-9-22-24(11-15)34-14-21(29-25(31)16(2)28-3)26(32)30(22)13-20-19-8-7-18(27)12-17(19)6-10-23(20)33-4/h5-12,16,21,28H,13-14H2,1-4H3,(H,29,31)/t16-,21-/m0/s1 SIOLYMCSTIOYGU-KKSFZXQISA-N 237624 US9394263, 36 E3 ubiquitin-protein ligase XIAP [124-240] 80 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237624&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060626 340131093 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414115 COc1ccc2cc(Br)ccc2c1CN1c2ccc(C)cc2OC[C@H](NC(=O)[C@@H](N)[C@@H](C)O)C1=O InChI=1S/C26H28BrN3O5/c1-14-4-8-21-23(10-14)35-13-20(29-25(32)24(28)15(2)31)26(33)30(21)12-19-18-7-6-17(27)11-16(18)5-9-22(19)34-3/h4-11,15,20,24,31H,12-13,28H2,1-3H3,(H,29,32)/t15-,20+,24+/m1/s1 GJHQSQQUFJDDTR-VNOPPTIDSA-N 237625 US9394263, 37 E3 ubiquitin-protein ligase XIAP [124-240] 7080 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237625 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237625&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060723 340131094 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414116 COc1ccc2cc(Br)ccc2c1CN1c2ccc(C)cc2OC[C@H](NC(=O)[C@@H](N)[C@H](C)O)C1=O InChI=1S/C26H28BrN3O5/c1-14-4-8-21-23(10-14)35-13-20(29-25(32)24(28)15(2)31)26(33)30(21)12-19-18-7-6-17(27)11-16(18)5-9-22(19)34-3/h4-11,15,20,24,31H,12-13,28H2,1-3H3,(H,29,32)/t15-,20-,24-/m0/s1 GJHQSQQUFJDDTR-CCQPRUGESA-N 237626 US9394263, 38 E3 ubiquitin-protein ligase XIAP [124-240] 77 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237626 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237626&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060699 340131095 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414117 CN[C@@H](C)C(=O)N[C@H]1[C@H](C)Oc2cc(C)ccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C27H30BrN3O4/c1-15-6-10-22-24(12-15)35-17(3)25(30-26(32)16(2)29-4)27(33)31(22)14-21-20-9-8-19(28)13-18(20)7-11-23(21)34-5/h6-13,16-17,25,29H,14H2,1-5H3,(H,30,32)/t16-,17-,25-/m0/s1 XYXKAUGBKYDYDB-TZPNTHKFSA-N 237627 US9394263, 39 E3 ubiquitin-protein ligase XIAP [124-240] 54 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237627 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237627&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054024 340131096 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414118 CN[C@@H](C)C(=O)N[C@H]1[C@H](C)Oc2cc(C)ccc2N(Cc2c(OC)ccc3cc(ccc23)C(=O)OC)C1=O InChI=1S/C29H33N3O6/c1-16-7-11-23-25(13-16)38-18(3)26(31-27(33)17(2)30-4)28(34)32(23)15-22-21-10-8-20(29(35)37-6)14-19(21)9-12-24(22)36-5/h7-14,17-18,26,30H,15H2,1-6H3,(H,31,33)/t17-,18-,26-/m0/s1 GLMYCUJMYACUKQ-XWXLMPLOSA-N 237628 US9394263, 40 E3 ubiquitin-protein ligase XIAP [124-240] 80 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237628 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237628&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054292 340131097 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414119 CN[C@@H]([C@H](C)O)C(=O)N[C@H]1[C@H](C)Oc2cc(C)ccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C28H32BrN3O5/c1-15-6-10-22-24(12-15)37-17(3)26(31-27(34)25(30-4)16(2)33)28(35)32(22)14-21-20-9-8-19(29)13-18(20)7-11-23(21)36-5/h6-13,16-17,25-26,30,33H,14H2,1-5H3,(H,31,34)/t16-,17-,25-,26-/m0/s1 LKIFTWKEGXUQGG-FRSFCCSCSA-N 237629 US9394263, 41 E3 ubiquitin-protein ligase XIAP [124-240] 82 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237629 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237629&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060725 340131098 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414120 CN[C@@H](C)C(=O)N[C@H]1COc2ccc(cc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O)C(F)(F)F InChI=1S/C26H25BrF3N3O4/c1-14(31-2)24(34)32-20-13-37-23-9-5-16(26(28,29)30)11-21(23)33(25(20)35)12-19-18-7-6-17(27)10-15(18)4-8-22(19)36-3/h4-11,14,20,31H,12-13H2,1-3H3,(H,32,34)/t14-,20-/m0/s1 JQVJYOMQBVYRMG-XOBRGWDASA-N 237630 US9394263, 42 E3 ubiquitin-protein ligase XIAP [124-240] 57 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237630 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237630&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054296 340131099 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414121 CN[C@@H](C)C(=O)N[C@H]1[C@H](C)Oc2ccc(cc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O)C(F)(F)F InChI=1S/C27H27BrF3N3O4/c1-14(32-3)25(35)33-24-15(2)38-23-10-6-17(27(29,30)31)12-21(23)34(26(24)36)13-20-19-8-7-18(28)11-16(19)5-9-22(20)37-4/h5-12,14-15,24,32H,13H2,1-4H3,(H,33,35)/t14-,15-,24-/m0/s1 OALZJUACHCHIBD-ISQRANHSSA-N 237631 US9394263, 43 E3 ubiquitin-protein ligase XIAP [124-240] 92 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237631 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237631&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054298 340131100 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414122 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(C)ccc3ccccc23)C1=O InChI=1S/C25H27N3O3/c1-16-12-13-18-8-4-5-9-19(18)20(16)14-28-22-10-6-7-11-23(22)31-15-21(25(28)30)27-24(29)17(2)26-3/h4-13,17,21,26H,14-15H2,1-3H3,(H,27,29)/t17-,21-/m0/s1 PMTGJZLNFRQBBN-UWJYYQICSA-N 237632 US9394263, 44 E3 ubiquitin-protein ligase XIAP [124-240] 845 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237632 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237632&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054588 340131101 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414123 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2ccccc2Cl)C1=O InChI=1S/C20H22ClN3O3/c1-13(22-2)19(25)23-16-12-27-18-10-6-5-9-17(18)24(20(16)26)11-14-7-3-4-8-15(14)21/h3-10,13,16,22H,11-12H2,1-2H3,(H,23,25)/t13-,16-/m0/s1 GIKBDINPWKIYJA-BBRMVZONSA-N 237633 US9394263, 45 E3 ubiquitin-protein ligase XIAP [124-240] 5608 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237633 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237633&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054589 340131102 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414124 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2cccc(Cl)c2)C1=O InChI=1S/C20H22ClN3O3/c1-13(22-2)19(25)23-16-12-27-18-9-4-3-8-17(18)24(20(16)26)11-14-6-5-7-15(21)10-14/h3-10,13,16,22H,11-12H2,1-2H3,(H,23,25)/t13-,16-/m0/s1 PQRLHLPVCHREAB-BBRMVZONSA-N 237634 US9394263, 46 E3 ubiquitin-protein ligase XIAP [124-240] 3105 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237634 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237634&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054590 340131103 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414125 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2ccc(Cl)cc2)C1=O InChI=1S/C20H22ClN3O3/c1-13(22-2)19(25)23-16-12-27-18-6-4-3-5-17(18)24(20(16)26)11-14-7-9-15(21)10-8-14/h3-10,13,16,22H,11-12H2,1-2H3,(H,23,25)/t13-,16-/m0/s1 NZGXRNHLIKDWHR-BBRMVZONSA-N 237635 US9394263, 47 E3 ubiquitin-protein ligase XIAP [124-240] 6031 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237635 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237635&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054591 340131104 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414126 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(O)=O)N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C26H26BrN3O6/c1-14(28-2)24(31)29-20-13-36-23-18(26(33)34)5-4-6-21(23)30(25(20)32)12-19-17-9-8-16(27)11-15(17)7-10-22(19)35-3/h4-11,14,20,28H,12-13H2,1-3H3,(H,29,31)(H,33,34)/t14-,20-/m0/s1 RLXORJZNFQJZRM-XOBRGWDASA-N 237636 US9394263, 48 E3 ubiquitin-protein ligase XIAP [124-240] 89 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237636 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237636&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054593 340131105 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414127 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(O)=O)N(Cc2c(OC)ccc3ccccc23)C1=O InChI=1S/C26H27N3O6/c1-15(27-2)24(30)28-20-14-35-23-18(26(32)33)9-6-10-21(23)29(25(20)31)13-19-17-8-5-4-7-16(17)11-12-22(19)34-3/h4-12,15,20,27H,13-14H2,1-3H3,(H,28,30)(H,32,33)/t15-,20-/m0/s1 USEHOLSOYKSOSD-YWZLYKJASA-N 237637 US9394263, 49 E3 ubiquitin-protein ligase XIAP [124-240] 164 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237637&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73057219 340131106 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414128 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(=O)NCCC(O)=O)N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C29H31BrN4O7/c1-16(31-2)27(37)33-22-15-41-26-20(28(38)32-12-11-25(35)36)5-4-6-23(26)34(29(22)39)14-21-19-9-8-18(30)13-17(19)7-10-24(21)40-3/h4-10,13,16,22,31H,11-12,14-15H2,1-3H3,(H,32,38)(H,33,37)(H,35,36)/t16-,22-/m0/s1 QXWFRZXIEMDIMN-AOMKIAJQSA-N 237638 US9394263, 50 E3 ubiquitin-protein ligase XIAP [124-240] 134 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237638&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054852 340131107 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414129 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(=O)NCc2ccc(cc2)C(=O)OC)N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C35H35BrN4O7/c1-20(37-2)32(41)39-28-19-47-31-26(33(42)38-17-21-8-10-22(11-9-21)35(44)46-4)6-5-7-29(31)40(34(28)43)18-27-25-14-13-24(36)16-23(25)12-15-30(27)45-3/h5-16,20,28,37H,17-19H2,1-4H3,(H,38,42)(H,39,41)/t20-,28-/m0/s1 BLONQRBSZCSXHN-MMTVBGGISA-N 237639 US9394263, 51 E3 ubiquitin-protein ligase XIAP [124-240] 410 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237639&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054853 340131108 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414130 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(O)=O)N(Cc2c(OC)ccc3cc(ccc23)C(O)=O)C1=O InChI=1S/C27H27N3O8/c1-14(28-2)24(31)29-20-13-38-23-18(27(35)36)5-4-6-21(23)30(25(20)32)12-19-17-9-7-16(26(33)34)11-15(17)8-10-22(19)37-3/h4-11,14,20,28H,12-13H2,1-3H3,(H,29,31)(H,33,34)(H,35,36)/t14-,20-/m0/s1 UBDIHOBHGQIEPP-XOBRGWDASA-N 237640 US9394263, 52 E3 ubiquitin-protein ligase XIAP [124-240] 59 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237640&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054855 340131109 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414131 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(=O)N(C)CCO)N(Cc2c(OC)ccc3cc(ccc23)C(O)=O)C1=O InChI=1S/C30H34N4O8/c1-17(31-2)27(36)32-23-16-42-26-21(28(37)33(3)12-13-35)6-5-7-24(26)34(29(23)38)15-22-20-10-8-19(30(39)40)14-18(20)9-11-25(22)41-4/h5-11,14,17,23,31,35H,12-13,15-16H2,1-4H3,(H,32,36)(H,39,40)/t17-,23-/m0/s1 KCOWEPRSFVLMKN-SBUREZEXSA-N 237641 US9394263, 53 E3 ubiquitin-protein ligase XIAP [124-240] 90 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237641&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73054857 340131110 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414132 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(O)=O)N(Cc2ccc(Br)c3ccccc23)C1=O InChI=1S/C25H24BrN3O5/c1-14(27-2)23(30)28-20-13-34-22-18(25(32)33)8-5-9-21(22)29(24(20)31)12-15-10-11-19(26)17-7-4-3-6-16(15)17/h3-11,14,20,27H,12-13H2,1-2H3,(H,28,30)(H,32,33)/t14-,20-/m0/s1 SUBSTMCCUIICSI-XOBRGWDASA-N 237642 US9394263, 54 E3 ubiquitin-protein ligase XIAP [124-240] 649 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237642&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73055134 340131111 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414133 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(=O)N2CCN(CCO)CC2)N(Cc2ccc(Br)c3ccccc23)C1=O InChI=1S/C31H36BrN5O5/c1-20(33-2)29(39)34-26-19-42-28-24(30(40)36-14-12-35(13-15-36)16-17-38)8-5-9-27(28)37(31(26)41)18-21-10-11-25(32)23-7-4-3-6-22(21)23/h3-11,20,26,33,38H,12-19H2,1-2H3,(H,34,39)/t20-,26-/m0/s1 VLWUWJOMYZATBO-FNZWTVRRSA-N 237643 US9394263, 55 E3 ubiquitin-protein ligase XIAP [124-240] 957 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237643&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73055135 340131112 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414134 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(=O)N2CCN(CCCO)CC2)N(Cc2ccc(Br)c3ccccc23)C1=O InChI=1S/C32H38BrN5O5/c1-21(34-2)30(40)35-27-20-43-29-25(31(41)37-16-14-36(15-17-37)13-6-18-39)9-5-10-28(29)38(32(27)42)19-22-11-12-26(33)24-8-4-3-7-23(22)24/h3-5,7-12,21,27,34,39H,6,13-20H2,1-2H3,(H,35,40)/t21-,27-/m0/s1 FTLFWECWQDBFNU-IDISGSTGSA-N 237644 US9394263, 56 E3 ubiquitin-protein ligase XIAP [124-240] 1601 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237644&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73055136 340131113 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414135 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(Cl)n(-c3ccccc3C#N)c3ccccc23)C1=O InChI=1S/C29H26ClN5O3/c1-18(32-2)28(36)33-22-17-38-26-14-8-7-13-25(26)34(29(22)37)16-21-20-10-4-6-12-24(20)35(27(21)30)23-11-5-3-9-19(23)15-31/h3-14,18,22,32H,16-17H2,1-2H3,(H,33,36)/t18-,22-/m0/s1 IHVOEWKFQHMHHV-AVRDEDQJSA-N 237645 US9394263, 57 E3 ubiquitin-protein ligase XIAP [124-240] 15 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237645&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73055137 340131114 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414136 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2cccc3n(ccc23)-c2ccccc2C#N)C1=O InChI=1S/C29H27N5O3/c1-19(31-2)28(35)32-23-18-37-27-13-6-5-11-26(27)34(29(23)36)17-21-9-7-12-25-22(21)14-15-33(25)24-10-4-3-8-20(24)16-30/h3-15,19,23,31H,17-18H2,1-2H3,(H,32,35)/t19-,23-/m0/s1 XVSPJSXQUDWMJL-CVDCTZTESA-N 237646 US9394263, 58 E3 ubiquitin-protein ligase XIAP [124-240] 1159 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237646&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73055138 340131115 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414137 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(Cl)n(c3ccccc23)S(=O)(=O)c2ccccc2)C1=O InChI=1S/C28H27ClN4O5S/c1-18(30-2)27(34)31-22-17-38-25-15-9-8-14-24(25)32(28(22)35)16-21-20-12-6-7-13-23(20)33(26(21)29)39(36,37)19-10-4-3-5-11-19/h3-15,18,22,30H,16-17H2,1-2H3,(H,31,34)/t18-,22-/m0/s1 OWLACGCWCXSYAA-AVRDEDQJSA-N 237647 US9394263, 59 E3 ubiquitin-protein ligase XIAP [124-240] 45 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237647&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73055427 340131116 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414138 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2cccc3CN(Cc23)S(C)(=O)=O)C1=O InChI=1S/C23H28N4O5S/c1-15(24-2)22(28)25-19-14-32-21-10-5-4-9-20(21)27(23(19)29)12-17-8-6-7-16-11-26(13-18(16)17)33(3,30)31/h4-10,15,19,24H,11-14H2,1-3H3,(H,25,28)/t15-,19-/m0/s1 IVBUOINKIBZNHL-KXBFYZLASA-N 237648 US9394263, 60 E3 ubiquitin-protein ligase XIAP [124-240] 1737 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237648&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060610 340131117 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414139 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2cc(=O)n(C)c3ccc(F)cc23)C1=O InChI=1S/C24H25FN4O4/c1-14(26-2)23(31)27-18-13-33-21-7-5-4-6-20(21)29(24(18)32)12-15-10-22(30)28(3)19-9-8-16(25)11-17(15)19/h4-11,14,18,26H,12-13H2,1-3H3,(H,27,31)/t14-,18-/m0/s1 PMDXADUCFFKNBG-KSSFIOAISA-N 237649 US9394263, 61 E3 ubiquitin-protein ligase XIAP [124-240] 686 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237649&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73055430 340131118 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414140 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2c(Cl)n(Cc3ccccc3)c3ccccc23)C1=O InChI=1S/C29H29ClN4O3/c1-19(31-2)28(35)32-23-18-37-26-15-9-8-14-25(26)34(29(23)36)17-22-21-12-6-7-13-24(21)33(27(22)30)16-20-10-4-3-5-11-20/h3-15,19,23,31H,16-18H2,1-2H3,(H,32,35)/t19-,23-/m0/s1 IOHRCWWNKMUJHT-CVDCTZTESA-N 237650 US9394263, 62 E3 ubiquitin-protein ligase XIAP [124-240] 167 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237650&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90037779 340131119 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414141 CCN1C(=O)Cc2c1cccc2CN1c2ccccc2OC[C@H](NC(=O)[C@H](C)NC)C1=O InChI=1S/C24H28N4O4/c1-4-27-19-10-7-8-16(17(19)12-22(27)29)13-28-20-9-5-6-11-21(20)32-14-18(24(28)31)26-23(30)15(2)25-3/h5-11,15,18,25H,4,12-14H2,1-3H3,(H,26,30)/t15-,18-/m0/s1 FJKGNKQMJJKBRW-YJBOKZPZSA-N 237651 US9394263, 63 E3 ubiquitin-protein ligase XIAP [124-240] 1121 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237651&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73055432 340131120 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414142 C[C@H](N)C(=O)N[C@H]1COc2ccccc2N(Cc2cccc3n(ncc23)-c2ccccc2C#N)C1=O InChI=1S/C27H24N6O3/c1-17(29)26(34)31-21-16-36-25-12-5-4-10-24(25)32(27(21)35)15-19-8-6-11-23-20(19)14-30-33(23)22-9-3-2-7-18(22)13-28/h2-12,14,17,21H,15-16,29H2,1H3,(H,31,34)/t17-,21-/m0/s1 WKHYVISBSHMTKP-UWJYYQICSA-N 237652 US9394263, 64 E3 ubiquitin-protein ligase XIAP [124-240] 69 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237652&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060606 340131121 C03803 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414143 CN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2cccc3n(c(cc23)C#N)-c2ccccc2C#N)C1=O InChI=1S/C30H26N6O3/c1-19(33-2)29(37)34-24-18-39-28-13-6-5-11-27(28)35(30(24)38)17-21-9-7-12-26-23(21)14-22(16-32)36(26)25-10-4-3-8-20(25)15-31/h3-14,19,24,33H,17-18H2,1-2H3,(H,34,37)/t19-,24-/m0/s1 POIRGBLAIOEGMB-CYFREDJKSA-N 237653 US9394263, 65 E3 ubiquitin-protein ligase XIAP [124-240] 21 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237653&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060641 340131122 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414144 C[C@H](NC1COC1)C(=O)N[C@H]1COc2ccccc2N(Cc2nn(-c3ccccc3C#N)c3ccccc23)C1=O InChI=1S/C30H28N6O4/c1-19(32-21-16-39-17-21)29(37)33-24-18-40-28-13-7-6-12-27(28)35(30(24)38)15-23-22-9-3-5-11-26(22)36(34-23)25-10-4-2-8-20(25)14-31/h2-13,19,21,24,32H,15-18H2,1H3,(H,33,37)/t19-,24-/m0/s1 PGJMPWDEKYBAAZ-CYFREDJKSA-N 237654 US9394263, 66 E3 ubiquitin-protein ligase XIAP [124-240] 7389 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237654&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73055732 340131123 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414145 C[C@H](NCC(C)(C)O)C(=O)N[C@H]1COc2ccccc2N(Cc2cccc3n(ncc23)-c2ccccc2C#N)C1=O InChI=1S/C31H32N6O4/c1-20(33-19-31(2,3)40)29(38)35-24-18-41-28-14-7-6-12-27(28)36(30(24)39)17-22-10-8-13-26-23(22)16-34-37(26)25-11-5-4-9-21(25)15-32/h4-14,16,20,24,33,40H,17-19H2,1-3H3,(H,35,38)/t20-,24-/m0/s1 MIQFPRXCDOPCKU-RDPSFJRHSA-N 237655 US9394263, 67 E3 ubiquitin-protein ligase XIAP [124-240] 1017 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237655&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060724 340131124 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414146 C[C@H](NCCO)C(=O)N[C@H]1COc2ccccc2N(Cc2cccc3n(ncc23)-c2ccccc2C#N)C1=O InChI=1S/C29H28N6O4/c1-19(31-13-14-36)28(37)33-23-18-39-27-12-5-4-10-26(27)34(29(23)38)17-21-8-6-11-25-22(21)16-32-35(25)24-9-3-2-7-20(24)15-30/h2-12,16,19,23,31,36H,13-14,17-18H2,1H3,(H,33,37)/t19-,23-/m0/s1 NUMQYQPKPFUALH-CVDCTZTESA-N 237656 US9394263, 68 E3 ubiquitin-protein ligase XIAP [124-240] 116 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237656&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060578 340131125 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414147 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2cccc3n(ncc23)-c2ccccc2C#N)c2ccccc2OC11CCOCC1 InChI=1S/C32H32N6O4/c1-21(34-2)30(39)36-29-31(40)37(27-11-5-6-13-28(27)42-32(29)14-16-41-17-15-32)20-23-9-7-12-26-24(23)19-35-38(26)25-10-4-3-8-22(25)18-33/h3-13,19,21,29,34H,14-17,20H2,1-2H3,(H,36,39)/t21-,29+/m0/s1 KZUUTKNHIHFFEC-KCWXNJEJSA-N 237657 US9394263, 69 E3 ubiquitin-protein ligase XIAP [124-240] 183 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237657&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060670 340131126 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414148 CCN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2cccc3n(ncc23)-c2ccccc2C#N)C1=O InChI=1S/C29H28N6O3/c1-3-31-19(2)28(36)33-23-18-38-27-14-7-6-12-26(27)34(29(23)37)17-21-10-8-13-25-22(21)16-32-35(25)24-11-5-4-9-20(24)15-30/h4-14,16,19,23,31H,3,17-18H2,1-2H3,(H,33,36)/t19-,23-/m0/s1 AUFVXUDNOWJJDV-CVDCTZTESA-N 237679 US9394263, 70 E3 ubiquitin-protein ligase XIAP [124-240] 183 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237679 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237679&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 129012535 340131148 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414149 CCN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2cc(F)cc3n(ncc23)-c2ccccc2C#N)C1=O InChI=1S/C29H27FN6O3/c1-3-32-18(2)28(37)34-23-17-39-27-11-7-6-10-25(27)35(29(23)38)16-20-12-21(30)13-26-22(20)15-33-36(26)24-9-5-4-8-19(24)14-31/h4-13,15,18,23,32H,3,16-17H2,1-2H3,(H,34,37)/t18-,23-/m0/s1 NSAFEIQIDVWJTB-MBSDFSHPSA-N 237658 US9394263, 71 E3 ubiquitin-protein ligase XIAP [124-240] 227 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237658&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060671 340131127 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414150 CCN[C@@H](C)C(=O)N[C@H]1COc2ccccc2N(Cc2cc(Br)cc3n(ncc23)-c2ccccc2C#N)C1=O InChI=1S/C29H27BrN6O3/c1-3-32-18(2)28(37)34-23-17-39-27-11-7-6-10-25(27)35(29(23)38)16-20-12-21(30)13-26-22(20)15-33-36(26)24-9-5-4-8-19(24)14-31/h4-13,15,18,23,32H,3,16-17H2,1-2H3,(H,34,37)/t18-,23-/m0/s1 OGWWABSRIAKEMM-MBSDFSHPSA-N 237659 US9394263, 72 E3 ubiquitin-protein ligase XIAP [124-240] 281 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237659&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060741 340131128 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414151 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2cccc3n(c(cc23)C#N)-c2ccccc2C#N)c2ccccc2OC11CCOCC1 InChI=1S/C34H32N6O4/c1-22(37-2)32(41)38-31-33(42)39(29-11-5-6-13-30(29)44-34(31)14-16-43-17-15-34)21-24-9-7-12-28-26(24)18-25(20-36)40(28)27-10-4-3-8-23(27)19-35/h3-13,18,22,31,37H,14-17,21H2,1-2H3,(H,38,41)/t22-,31+/m0/s1 NOHIOXNNRUHMPA-WKRVVKTRSA-N 237660 US9394263, 73 E3 ubiquitin-protein ligase XIAP [124-240] 32 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237660&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060642 340131129 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414152 CCN[C@@H](C)C(=O)N[C@H]1[C@H](C)Oc2ccccc2N(Cc2cccc3n(ncc23)-c2ccccc2C#N)C1=O InChI=1S/C30H30N6O3/c1-4-32-19(2)29(37)34-28-20(3)39-27-15-8-7-13-26(27)35(30(28)38)18-22-11-9-14-25-23(22)17-33-36(25)24-12-6-5-10-21(24)16-31/h5-15,17,19-20,28,32H,4,18H2,1-3H3,(H,34,37)/t19-,20-,28-/m0/s1 QDXYUTXYOLYCMB-JVAKCPTJSA-N 237661 US9394263, 74 E3 ubiquitin-protein ligase XIAP [124-240] 146 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237661&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 118586173 340131130 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414153 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2cccc3n(c(cc23)C#N)-c2ccccc2C#N)c2ccccc2SC1(C)C InChI=1S/C32H30N6O2S/c1-20(35-4)30(39)36-29-31(40)37(27-13-7-8-15-28(27)41-32(29,2)3)19-22-11-9-14-26-24(22)16-23(18-34)38(26)25-12-6-5-10-21(25)17-33/h5-16,20,29,35H,19H2,1-4H3,(H,36,39)/t20-,29+/m0/s1 DECOJDQHNHTGTL-AFJIDDCJSA-N 237662 US9394263, 75 E3 ubiquitin-protein ligase XIAP [124-240] 249 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237662&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060652 340131131 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414154 CN[C@@H](C)C(=O)N[C@H]1[C@H](C)Oc2ccccc2N(Cc2cccc3n(c(cc23)C#N)-c2ccccc2C#N)C1=O InChI=1S/C31H28N6O3/c1-19(34-3)30(38)35-29-20(2)40-28-14-7-6-12-27(28)36(31(29)39)18-22-10-8-13-26-24(22)15-23(17-33)37(26)25-11-5-4-9-21(25)16-32/h4-15,19-20,29,34H,18H2,1-3H3,(H,35,38)/t19-,20-,29-/m0/s1 KHKFKZNJPUHKFA-SGHJWQDXSA-N 237663 US9394263, 76 E3 ubiquitin-protein ligase XIAP [124-240] 31 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237663&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060662 340131132 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414155 CCN[C@@H](C)C(=O)N[C@H]1[C@H](C)Oc2ccccc2N(Cc2cccc3n(c(cc23)C#N)-c2ccccc2C#N)C1=O InChI=1S/C32H30N6O3/c1-4-35-20(2)31(39)36-30-21(3)41-29-15-8-7-13-28(29)37(32(30)40)19-23-11-9-14-27-25(23)16-24(18-34)38(27)26-12-6-5-10-22(26)17-33/h5-16,20-21,30,35H,4,19H2,1-3H3,(H,36,39)/t20-,21-,30-/m0/s1 INAYPXBFUPXVKY-LPBFERMMSA-N 237664 US9394263, 77 E3 ubiquitin-protein ligase XIAP [124-240] 107 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237664&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060675 340131133 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414156 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2cccc3n(ncc23)-c2ccccc2C#N)c2ccc(Br)cc2OC11CCOCC1 InChI=1S/C32H31BrN6O4/c1-20(35-2)30(40)37-29-31(41)38(27-11-10-23(33)16-28(27)43-32(29)12-14-42-15-13-32)19-22-7-5-9-26-24(22)18-36-39(26)25-8-4-3-6-21(25)17-34/h3-11,16,18,20,29,35H,12-15,19H2,1-2H3,(H,37,40)/t20-,29+/m0/s1 WLCBYDQXWPRQBT-AFJIDDCJSA-N 237665 US9394263, 78 E3 ubiquitin-protein ligase XIAP [124-240] 67 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237665&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060676 340131134 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414157 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2nn(-c3ccccc3C#N)c3ccccc23)c2ccc(cc2OC11CCOCC1)C#N InChI=1S/C33H31N7O4/c1-21(36-2)31(41)37-30-32(42)39(28-12-11-22(18-34)17-29(28)44-33(30)13-15-43-16-14-33)20-25-24-8-4-6-10-27(24)40(38-25)26-9-5-3-7-23(26)19-35/h3-12,17,21,30,36H,13-16,20H2,1-2H3,(H,37,41)/t21-,30+/m0/s1 VHZOTCUSUQHZSC-URAOTHONSA-N 237666 US9394263, 79 E3 ubiquitin-protein ligase XIAP [124-240] 151 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237666&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73056597 340131135 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414158 CN[C@@H](C)C(=O)N[C@H]1[C@H](C)Oc2ccccc2N(Cc2cccc3n(ncc23)-c2ccc(cc2C#N)C(O)=O)C1=O InChI=1S/C30H28N6O5/c1-17(32-3)28(37)34-27-18(2)41-26-10-5-4-8-25(26)35(29(27)38)16-20-7-6-9-24-22(20)15-33-36(24)23-12-11-19(30(39)40)13-21(23)14-31/h4-13,15,17-18,27,32H,16H2,1-3H3,(H,34,37)(H,39,40)/t17-,18-,27-/m0/s1 UABHKXRZUPPGRI-VFUKXHBFSA-N 237667 US9394263, 80 E3 ubiquitin-protein ligase XIAP [124-240] 118 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237667&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060674 340131136 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414159 CCNC(=O)c1ccc(c(c1)C#N)-n1ncc2c(CN3c4ccccc4O[C@@H](C)[C@H](NC(=O)[C@H](C)NC)C3=O)cccc12 InChI=1S/C32H33N7O4/c1-5-35-31(41)21-13-14-25(23(15-21)16-33)39-26-11-8-9-22(24(26)17-36-39)18-38-27-10-6-7-12-28(27)43-20(3)29(32(38)42)37-30(40)19(2)34-4/h6-15,17,19-20,29,34H,5,18H2,1-4H3,(H,35,41)(H,37,40)/t19-,20-,29-/m0/s1 OICHJWNMJNGMBK-SGHJWQDXSA-N 237668 US9394263, 81 E3 ubiquitin-protein ligase XIAP [124-240] 132 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237668&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060740 340131137 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414160 CC[C@H](NC)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C26H28BrN3O4/c1-4-20(28-2)25(31)29-21-15-34-24-8-6-5-7-22(24)30(26(21)32)14-19-18-11-10-17(27)13-16(18)9-12-23(19)33-3/h5-13,20-21,28H,4,14-15H2,1-3H3,(H,29,31)/t20-,21-/m0/s1 ZABPEKQABCBHGI-SFTDATJTSA-N 237669 US9394263, 82 E3 ubiquitin-protein ligase XIAP [124-240] 14 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237669&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 72943442 340131138 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414161 CC[C@H](NCCO)C(=O)N[C@H]1COc2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C27H30BrN3O5/c1-3-21(29-12-13-32)26(33)30-22-16-36-25-7-5-4-6-23(25)31(27(22)34)15-20-19-10-9-18(28)14-17(19)8-11-24(20)35-2/h4-11,14,21-22,29,32H,3,12-13,15-16H2,1-2H3,(H,30,33)/t21-,22-/m0/s1 QQUFUPCYPJPULX-VXKWHMMOSA-N 237670 US9394263, 83 E3 ubiquitin-protein ligase XIAP [124-240] 44 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237670&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73056601 340131139 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414162 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2noc3ccccc23)c2ccccc2OC11CCOCC1 InChI=1S/C25H28N4O5/c1-16(26-2)23(30)27-22-24(31)29(15-18-17-7-3-5-9-20(17)34-28-18)19-8-4-6-10-21(19)33-25(22)11-13-32-14-12-25/h3-10,16,22,26H,11-15H2,1-2H3,(H,27,30)/t16-,22+/m0/s1 RJNKRXWCPPRDRL-KSFYIVLOSA-N 50441336 CHEMBL2431753::US9394263, 84 E3 ubiquitin-protein ligase XIAP [124-240] 569 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50441336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50441336&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 72713169 175453653 CHEMBL2431753 ZINC96285022 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414163 CN[C@@H](C)C(=O)N[C@@H]1C(=O)N(Cc2c(OC(F)F)ccc3ccccc23)c2ccccc2OC11CCOCC1 InChI=1S/C29H31F2N3O5/c1-18(32-2)26(35)33-25-27(36)34(22-9-5-6-10-24(22)39-29(25)13-15-37-16-14-29)17-21-20-8-4-3-7-19(20)11-12-23(21)38-28(30)31/h3-12,18,25,28,32H,13-17H2,1-2H3,(H,33,35)/t18-,25+/m0/s1 GKZPMFPKQMBXTM-AVRWGWEMSA-N 50441339 CHEMBL2431750::US9394263, 85 E3 ubiquitin-protein ligase XIAP [124-240] 410 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50441339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50441339&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 72712973 175453656 CHEMBL2431750 ZINC96285025 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414164 CN[C@@H](C)C(=O)N[C@H]1C(=O)N(Cc2c(OC(F)F)ccc3ccccc23)c2ccccc2OC11CCOCC1 InChI=1S/C29H31F2N3O5/c1-18(32-2)26(35)33-25-27(36)34(22-9-5-6-10-24(22)39-29(25)13-15-37-16-14-29)17-21-20-8-4-3-7-19(20)11-12-23(21)38-28(30)31/h3-12,18,25,28,32H,13-17H2,1-2H3,(H,33,35)/t18-,25-/m0/s1 GKZPMFPKQMBXTM-BVZFJXPGSA-N 237671 US9394263, 86 E3 ubiquitin-protein ligase XIAP [124-240] 6406 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237671 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237671&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060686 340131140 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414165 CN[C@@H](C)C(=O)N[C@H]1COc2c(F)cccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C25H25BrFN3O4/c1-14(28-2)24(31)29-20-13-34-23-19(27)5-4-6-21(23)30(25(20)32)12-18-17-9-8-16(26)11-15(17)7-10-22(18)33-3/h4-11,14,20,28H,12-13H2,1-3H3,(H,29,31)/t14-,20-/m0/s1 RYQCPRFEDWNNIO-XOBRGWDASA-N 237672 US9394263, 87 E3 ubiquitin-protein ligase XIAP [124-240] 42 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237672 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237672&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73056909 340131141 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414166 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(F)(F)F)N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C26H25BrF3N3O4/c1-14(31-2)24(34)32-20-13-37-23-19(26(28,29)30)5-4-6-21(23)33(25(20)35)12-18-17-9-8-16(27)11-15(17)7-10-22(18)36-3/h4-11,14,20,31H,12-13H2,1-3H3,(H,32,34)/t14-,20-/m0/s1 YBXQKLWFRGIZLS-XOBRGWDASA-N 237673 US9394263, 88 E3 ubiquitin-protein ligase XIAP [124-240] 50 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237673&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73056911 340131142 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414167 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(F)(F)F)N(Cc2c(C)ccc3ccccc23)C1=O InChI=1S/C26H26F3N3O3/c1-15-11-12-17-7-4-5-8-18(17)19(15)13-32-22-10-6-9-20(26(27,28)29)23(22)35-14-21(25(32)34)31-24(33)16(2)30-3/h4-12,16,21,30H,13-14H2,1-3H3,(H,31,33)/t16-,21-/m0/s1 KRNCBQUHOCAEBO-KKSFZXQISA-N 237674 US9394263, 89 E3 ubiquitin-protein ligase XIAP [124-240] 142 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237674 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237674&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73056913 340131143 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414168 CN[C@@H](C)C(=O)N[C@H]1COc2c(cccc2C(F)(F)F)N(Cc2noc3ccccc23)C1=O InChI=1S/C22H21F3N4O4/c1-12(26-2)20(30)27-16-11-32-19-14(22(23,24)25)7-5-8-17(19)29(21(16)31)10-15-13-6-3-4-9-18(13)33-28-15/h3-9,12,16,26H,10-11H2,1-2H3,(H,27,30)/t12-,16-/m0/s1 SXPQQRPNTHDMSC-LRDDRELGSA-N 237675 US9394263, 90 E3 ubiquitin-protein ligase XIAP [124-240] 490 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237675 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237675&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73056915 340131144 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414169 CN[C@@H](C)C(=O)N[C@H]1COc2c(Br)cccc2N(Cc2c(C)ccc3ccccc23)C1=O InChI=1S/C25H26BrN3O3/c1-15-11-12-17-7-4-5-8-18(17)19(15)13-29-22-10-6-9-20(26)23(22)32-14-21(25(29)31)28-24(30)16(2)27-3/h4-12,16,21,27H,13-14H2,1-3H3,(H,28,30)/t16-,21-/m0/s1 XPHDLVAVZMWLKT-KKSFZXQISA-N 237676 US9394263, 91 E3 ubiquitin-protein ligase XIAP [124-240] 124 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237676 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237676&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73056917 340131145 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 414170 CN[C@@H](C)C(=O)N[C@H]1COc2c(C)cccc2N(Cc2c(OC)ccc3cc(C)ccc23)C1=O InChI=1S/C27H31N3O4/c1-16-9-11-20-19(13-16)10-12-24(33-5)21(20)14-30-23-8-6-7-17(2)25(23)34-15-22(27(30)32)29-26(31)18(3)28-4/h6-13,18,22,28H,14-15H2,1-5H3,(H,29,31)/t18-,22-/m0/s1 NTYSUSITGAPTCH-AVRDEDQJSA-N 237677 US9394263, 92 E3 ubiquitin-protein ligase XIAP [124-240] 27 7.5 25.00 C US Patent 10.7270/Q2X92968 aid1803159 US9394263 Donnell, AF; Han, X; Kester, RF; Kong, N; Le, K; Lou, Y; Michoud, C; Moliterni, JA; Remiszewski, S; Rupert, KC; Yun, W F. Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=237677 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=237677&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90060683 340131146 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420353 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(cc2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C58H56Br2N8O8/c1-33(61-3)53(69)63-45-31-67(49-13-9-7-11-47(49)65(57(45)73)29-43-41-23-21-39(59)27-37(41)19-25-51(43)75-5)55(71)35-15-17-36(18-16-35)56(72)68-32-46(64-54(70)34(2)62-4)58(74)66(48-12-8-10-14-50(48)68)30-44-42-24-22-40(60)28-38(42)20-26-52(44)76-6/h7-28,33-34,45-46,61-62H,29-32H2,1-6H3,(H,63,69)(H,64,70)/t33-,34-,45-,46-/m0/s1 PBGWEJJBQUBSJN-MLLHAFNLSA-N 240879 US9409888, 28 E3 ubiquitin-protein ligase XIAP [124-240] 0.289 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240879&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76283048 341093201 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420354 CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N1C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc12 InChI=1S/C60H70BrN9O8/c1-35(62-3)54(71)66-48-34-70(50-21-12-11-20-49(50)69(59(48)76)33-46-44-28-27-42(61)30-41(44)26-29-52(46)78-5)58(75)40-24-22-39(23-25-40)56(73)64-43-31-51(57(74)65-47-19-13-17-37-14-9-10-18-45(37)47)68(32-43)60(77)53(38-15-7-6-8-16-38)67-55(72)36(2)63-4/h9-12,14,18,20-30,35-36,38,43,47-48,51,53,62-63H,6-8,13,15-17,19,31-34H2,1-5H3,(H,64,73)(H,65,74)(H,66,71)(H,67,72)/t35-,36-,43-,47+,48-,51-,53-/m0/s1 OVCDDAXIBKWFRB-SFDZCEMOSA-N 240880 US9409888, 2 E3 ubiquitin-protein ligase XIAP [124-240] 3.11 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240880&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76282560 341093202 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420355 CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@@H](C[C@@H]1C(=O)NCc1ccccc1)NC(=O)c1ccc(cc1)C(=O)N1C[C@H](NC(=O)[C@@H](C)NC)C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc12 InChI=1S/C57H66BrN9O8/c1-34(59-3)51(68)63-45-33-67(47-19-13-12-18-46(47)66(56(45)73)32-44-43-26-25-41(58)28-40(43)24-27-49(44)75-5)55(72)39-22-20-38(21-23-39)53(70)62-42-29-48(54(71)61-30-36-14-8-6-9-15-36)65(31-42)57(74)50(37-16-10-7-11-17-37)64-52(69)35(2)60-4/h6,8-9,12-15,18-28,34-35,37,42,45,48,50,59-60H,7,10-11,16-17,29-33H2,1-5H3,(H,61,71)(H,62,70)(H,63,68)(H,64,69)/t34-,35+,42-,45+,48-,50+/m1/s1 YDWVAMSAICGKJN-BOPKTTDVSA-N 240881 US9409888, 1 E3 ubiquitin-protein ligase XIAP [124-240] 1.25 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240881&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 129625737 341093203 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420356 CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@H](C[C@H]1C(=O)N[C@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N1C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc12 InChI=1S/C60H70BrN9O8/c1-35(62-3)54(71)66-48-34-70(50-21-12-11-20-49(50)69(59(48)76)33-46-44-28-27-42(61)30-41(44)26-29-52(46)78-5)58(75)40-24-22-39(23-25-40)56(73)64-43-31-51(57(74)65-47-19-13-17-37-14-9-10-18-45(37)47)68(32-43)60(77)53(38-15-7-6-8-16-38)67-55(72)36(2)63-4/h9-12,14,18,20-30,35-36,38,43,47-48,51,53,62-63H,6-8,13,15-17,19,31-34H2,1-5H3,(H,64,73)(H,65,74)(H,66,71)(H,67,72)/t35-,36-,43-,47-,48-,51-,53-/m0/s1 OVCDDAXIBKWFRB-QNQROPCWSA-N 240882 US9409888, 3 E3 ubiquitin-protein ligase XIAP [124-240] 1.705 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240882&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76282561 341093204 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420357 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(cc2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(C)ccc4ccccc34)c3ccccc23)c2ccccc2N(Cc2c(C)ccc3ccccc23)C1=O InChI=1S/C58H58N8O6/c1-35-23-25-39-15-7-9-17-43(39)45(35)31-63-49-19-11-13-21-51(49)65(33-47(57(63)71)61-53(67)37(3)59-5)55(69)41-27-29-42(30-28-41)56(70)66-34-48(62-54(68)38(4)60-6)58(72)64(50-20-12-14-22-52(50)66)32-46-36(2)24-26-40-16-8-10-18-44(40)46/h7-30,37-38,47-48,59-60H,31-34H2,1-6H3,(H,61,67)(H,62,68)/t37-,38-,47-,48-/m0/s1 AAUBAAFAPIUNRC-IFXHEYSUSA-N 240883 US9409888, 23 E3 ubiquitin-protein ligase XIAP [124-240] 0.429 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240883 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240883&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76280748 341093205 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420358 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(cc2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4c(Br)cccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3c(Br)cccc23)C1=O InChI=1S/C58H56Br2N8O8/c1-33(61-3)53(69)63-45-31-67(49-19-9-7-17-47(49)65(57(45)73)29-41-37-13-11-15-43(59)39(37)25-27-51(41)75-5)55(71)35-21-23-36(24-22-35)56(72)68-32-46(64-54(70)34(2)62-4)58(74)66(48-18-8-10-20-50(48)68)30-42-38-14-12-16-44(60)40(38)26-28-52(42)76-6/h7-28,33-34,45-46,61-62H,29-32H2,1-6H3,(H,63,69)(H,64,70)/t33-,34-,45-,46-/m0/s1 YUIVBVLBUVLINM-MLLHAFNLSA-N 240884 US9409888, 22 E3 ubiquitin-protein ligase XIAP [124-240] 0.32 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240884 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240884&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76281540 341093206 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420359 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc3cc(ccc3c2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C62H58Br2N8O8/c1-35(65-3)57(73)67-49-33-71(53-13-9-7-11-51(53)69(61(49)77)31-47-45-23-21-43(63)29-39(45)19-25-55(47)79-5)59(75)41-17-15-38-28-42(18-16-37(38)27-41)60(76)72-34-50(68-58(74)36(2)66-4)62(78)70(52-12-8-10-14-54(52)72)32-48-46-24-22-44(64)30-40(46)20-26-56(48)80-6/h7-30,35-36,49-50,65-66H,31-34H2,1-6H3,(H,67,73)(H,68,74)/t35-,36-,49-,50-/m0/s1 JPGPASNCUPFQRJ-HLGNEWOLSA-N 240885 US9409888, 9 E3 ubiquitin-protein ligase XIAP [124-240] <0.051 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240885 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240885&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76283293 341093207 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420360 CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCCC1)NC(=O)c1ccc(cc1)C(=O)N1C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc12 InChI=1S/C56H70BrN9O8/c1-33(58-3)50(67)62-44-32-66(46-19-13-12-18-45(46)65(55(44)72)31-43-42-26-25-39(57)28-38(42)24-27-48(43)74-5)54(71)37-22-20-36(21-23-37)52(69)61-41-29-47(53(70)60-40-16-10-7-11-17-40)64(30-41)56(73)49(35-14-8-6-9-15-35)63-51(68)34(2)59-4/h12-13,18-28,33-35,40-41,44,47,49,58-59H,6-11,14-17,29-32H2,1-5H3,(H,60,70)(H,61,69)(H,62,67)(H,63,68)/t33-,34-,41-,44-,47-,49-/m0/s1 DUMCUFNHQURVRM-MUUCLWMVSA-N 240886 US9409888, 4 E3 ubiquitin-protein ligase XIAP [124-240] 4.585 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240886 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240886&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76282802 341093208 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420361 CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1C[C@H](C[C@H]1C(=O)NC(C)C)NC(=O)c1ccc(cc1)C(=O)N1C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc2c(OC)ccc3cc(Br)ccc23)c2ccccc12 InChI=1S/C53H66BrN9O8/c1-30(2)57-50(67)44-26-38(27-61(44)53(70)46(33-13-9-8-10-14-33)60-48(65)32(4)56-6)58-49(66)34-17-19-35(20-18-34)51(68)63-29-41(59-47(64)31(3)55-5)52(69)62(42-15-11-12-16-43(42)63)28-40-39-23-22-37(54)25-36(39)21-24-45(40)71-7/h11-12,15-25,30-33,38,41,44,46,55-56H,8-10,13-14,26-29H2,1-7H3,(H,57,67)(H,58,66)(H,59,64)(H,60,65)/t31-,32-,38-,41-,44-,46-/m0/s1 ZVTMZUQOSGTDGQ-OSHGBQKNSA-N 240887 US9409888, 5 E3 ubiquitin-protein ligase XIAP [124-240] 2.98 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240887 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240887&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76282803 341093209 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420362 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCC(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C54H56Br2N8O8/c1-31(57-3)51(67)59-41-29-61(43-11-7-9-13-45(43)63(53(41)69)27-39-37-19-17-35(55)25-33(37)15-21-47(39)71-5)49(65)23-24-50(66)62-30-42(60-52(68)32(2)58-4)54(70)64(46-14-10-8-12-44(46)62)28-40-38-20-18-36(56)26-34(38)16-22-48(40)72-6/h7-22,25-26,31-32,41-42,57-58H,23-24,27-30H2,1-6H3,(H,59,67)(H,60,68)/t31-,32-,41-,42-/m0/s1 ALIUHKXJZCMAAV-YDSDICBNSA-N 240888 US9409888, 15 E3 ubiquitin-protein ligase XIAP [124-240] 1.02 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240888 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240888&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76284044 341093210 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420363 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCCCC(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C56H60Br2N8O8/c1-33(59-3)53(69)61-43-31-63(45-13-7-9-15-47(45)65(55(43)71)29-41-39-23-21-37(57)27-35(39)19-25-49(41)73-5)51(67)17-11-12-18-52(68)64-32-44(62-54(70)34(2)60-4)56(72)66(48-16-10-8-14-46(48)64)30-42-40-24-22-38(58)28-36(40)20-26-50(42)74-6/h7-10,13-16,19-28,33-34,43-44,59-60H,11-12,17-18,29-32H2,1-6H3,(H,61,69)(H,62,70)/t33-,34-,43-,44-/m0/s1 XEUPNOJSSNQTHX-DYGKRUFJSA-N 240889 US9409888, 16 E3 ubiquitin-protein ligase XIAP [124-240] 0.375 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240889&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76284045 341093211 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420364 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(cc2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3nn(-c4ccccc4C#N)c4ccccc34)c3ccccc23)c2ccccc2N(Cc2nn(-c3ccccc3C#N)c3ccccc23)C1=O InChI=1S/C64H56N14O6/c1-39(67-3)59(79)69-49-37-73(55-25-13-15-27-57(55)75(63(49)83)35-47-45-19-7-11-23-53(45)77(71-47)51-21-9-5-17-43(51)33-65)61(81)41-29-31-42(32-30-41)62(82)74-38-50(70-60(80)40(2)68-4)64(84)76(58-28-16-14-26-56(58)74)36-48-46-20-8-12-24-54(46)78(72-48)52-22-10-6-18-44(52)34-66/h5-32,39-40,49-50,67-68H,35-38H2,1-4H3,(H,69,79)(H,70,80)/t39-,40-,49-,50-/m0/s1 SQXNCAKESJTANY-UCUXQBEDSA-N 240890 US9409888, 24 E3 ubiquitin-protein ligase XIAP [124-240] 1.58 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240890 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240890&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76281014 341093212 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420365 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2cnc(cn2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C56H54Br2N10O8/c1-31(59-3)51(69)63-43-29-67(47-13-9-7-11-45(47)65(55(43)73)27-39-37-19-17-35(57)23-33(37)15-21-49(39)75-5)53(71)41-25-62-42(26-61-41)54(72)68-30-44(64-52(70)32(2)60-4)56(74)66(46-12-8-10-14-48(46)68)28-40-38-20-18-36(58)24-34(38)16-22-50(40)76-6/h7-26,31-32,43-44,59-60H,27-30H2,1-6H3,(H,63,69)(H,64,70)/t31-,32-,43-,44-/m0/s1 GXFYCRZLAIFTMD-XAGGQHATSA-N 240892 US9409888, 19 E3 ubiquitin-protein ligase XIAP [124-240] 0.325 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240892&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76284571 341093214 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420366 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(cc2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(C)ccc4ccccc34)c3ccc(cc23)C#N)c2cc(ccc2N(Cc2c(C)ccc3ccccc23)C1=O)C#N InChI=1S/C60H56N10O6/c1-35-15-19-41-11-7-9-13-45(41)47(35)31-67-51-25-17-39(29-61)27-53(51)69(33-49(59(67)75)65-55(71)37(3)63-5)57(73)43-21-23-44(24-22-43)58(74)70-34-50(66-56(72)38(4)64-6)60(76)68(52-26-18-40(30-62)28-54(52)70)32-48-36(2)16-20-42-12-8-10-14-46(42)48/h7-28,37-38,49-50,63-64H,31-34H2,1-6H3,(H,65,71)(H,66,72)/t37-,38-,49-,50-/m0/s1 ABEWHESMNXBBBX-FJWUGETPSA-N 240893 US9409888, 26 E3 ubiquitin-protein ligase XIAP [124-240] 0.815 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240893 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240893&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90220954 341093215 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420367 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CC(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C53H54Br2N8O8/c1-30(56-3)50(66)58-40-28-60(42-11-7-9-13-44(42)62(52(40)68)26-38-36-19-17-34(54)23-32(36)15-21-46(38)70-5)48(64)25-49(65)61-29-41(59-51(67)31(2)57-4)53(69)63(45-14-10-8-12-43(45)61)27-39-37-20-18-35(55)24-33(37)16-22-47(39)71-6/h7-24,30-31,40-41,56-57H,25-29H2,1-6H3,(H,58,66)(H,59,67)/t30-,31-,40-,41-/m0/s1 USJKJTRCBBJPHQ-GCRRAVDUSA-N 240894 US9409888, 14 E3 ubiquitin-protein ligase XIAP [124-240] 1.43 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240894 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240894&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76284043 341093216 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420368 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCCCCC(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C57H62Br2N8O8/c1-34(60-3)54(70)62-44-32-64(46-14-10-12-16-48(46)66(56(44)72)30-42-40-24-22-38(58)28-36(40)20-26-50(42)74-5)52(68)18-8-7-9-19-53(69)65-33-45(63-55(71)35(2)61-4)57(73)67(49-17-13-11-15-47(49)65)31-43-41-25-23-39(59)29-37(41)21-27-51(43)75-6/h10-17,20-29,34-35,44-45,60-61H,7-9,18-19,30-33H2,1-6H3,(H,62,70)(H,63,71)/t34-,35-,44-,45-/m0/s1 UOOVZPYCEUOIRH-JXJQUFNJSA-N 240895 US9409888, 17 E3 ubiquitin-protein ligase XIAP [124-240] 0.307 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240895 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240895&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76284309 341093217 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420369 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2cccc(n2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C57H55Br2N9O8/c1-32(60-3)52(69)63-44-30-67(48-16-9-7-14-46(48)65(56(44)73)28-40-38-22-20-36(58)26-34(38)18-24-50(40)75-5)54(71)42-12-11-13-43(62-42)55(72)68-31-45(64-53(70)33(2)61-4)57(74)66(47-15-8-10-17-49(47)68)29-41-39-23-21-37(59)27-35(39)19-25-51(41)76-6/h7-27,32-33,44-45,60-61H,28-31H2,1-6H3,(H,63,69)(H,64,70)/t32-,33-,44-,45-/m0/s1 BYEWOHNSGVZTKI-GQZZGPPCSA-N 240896 US9409888, 7 E3 ubiquitin-protein ligase XIAP [124-240] 0.87 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240896 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240896&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76283049 341093218 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420370 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)CCCCCCC(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C58H64Br2N8O8/c1-35(61-3)55(71)63-45-33-65(47-15-11-13-17-49(47)67(57(45)73)31-43-41-25-23-39(59)29-37(41)21-27-51(43)75-5)53(69)19-9-7-8-10-20-54(70)66-34-46(64-56(72)36(2)62-4)58(74)68(50-18-14-12-16-48(50)66)32-44-42-26-24-40(60)30-38(42)22-28-52(44)76-6/h11-18,21-30,35-36,45-46,61-62H,7-10,19-20,31-34H2,1-6H3,(H,63,71)(H,64,72)/t35-,36-,45-,46-/m0/s1 BHKFQSLHSMCXAC-AQALWICOSA-N 240897 US9409888, 18 E3 ubiquitin-protein ligase XIAP [124-240] 0.8715 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240897 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240897&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76284310 341093219 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420371 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc3ccc(cc3c2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C62H58Br2N8O8/c1-35(65-3)57(73)67-49-33-71(53-13-9-7-11-51(53)69(61(49)77)31-47-45-23-21-43(63)29-38(45)19-25-55(47)79-5)59(75)40-17-15-37-16-18-41(28-42(37)27-40)60(76)72-34-50(68-58(74)36(2)66-4)62(78)70(52-12-8-10-14-54(52)72)32-48-46-24-22-44(64)30-39(46)20-26-56(48)80-6/h7-30,35-36,49-50,65-66H,31-34H2,1-6H3,(H,67,73)(H,68,74)/t35-,36-,49-,50-/m0/s1 DVCZULJQUBIBRA-HLGNEWOLSA-N 240898 US9409888, 20 E3 ubiquitin-protein ligase XIAP [124-240] 1.23 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240898 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240898&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76284572 341093220 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420372 CN[C@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(Oc3ccc(cc3)C(=O)N3C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc4c(OC)ccc5cc(Br)ccc45)c4ccccc34)cc2)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C64H60Br2N8O9/c1-37(67-3)59(75)69-51-35-73(55-13-9-7-11-53(55)71(63(51)79)33-49-47-27-21-43(65)31-41(47)19-29-57(49)81-5)61(77)39-15-23-45(24-16-39)83-46-25-17-40(18-26-46)62(78)74-36-52(70-60(76)38(2)68-4)64(80)72(54-12-8-10-14-56(54)74)34-50-48-28-22-44(66)32-42(48)20-30-58(50)82-6/h7-32,37-38,51-52,67-68H,33-36H2,1-6H3,(H,69,75)(H,70,76)/t37-,38+,51-,52-/m0/s1 XGUNLKVECPOSEU-YSFKWEKFSA-N 240899 US9409888, 11 E3 ubiquitin-protein ligase XIAP [124-240] 1.2 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240899 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240899&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 129625738 341093221 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420373 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(cc2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4ccccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3ccccc23)C1=O InChI=1S/C58H58N8O8/c1-35(59-3)53(67)61-45-33-65(49-21-13-11-19-47(49)63(57(45)71)31-43-41-17-9-7-15-37(41)27-29-51(43)73-5)55(69)39-23-25-40(26-24-39)56(70)66-34-46(62-54(68)36(2)60-4)58(72)64(48-20-12-14-22-50(48)66)32-44-42-18-10-8-16-38(42)28-30-52(44)74-6/h7-30,35-36,45-46,59-60H,31-34H2,1-6H3,(H,61,67)(H,62,68)/t35-,36-,45-,46-/m0/s1 JHXQJXZMVVMYBN-AQALWICOSA-N 240900 US9409888, 25 E3 ubiquitin-protein ligase XIAP [124-240] 0.452 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240900 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240900&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76281015 341093222 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420374 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(C(=O)N3C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc4c(OC)ccc5cc(Br)ccc45)c4ccccc34)c(C)c2)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C59H58Br2N8O8/c1-33-26-38(56(72)68-31-46(64-54(70)34(2)62-4)58(74)66(48-12-8-10-14-50(48)68)29-44-42-22-19-39(60)27-36(42)17-24-52(44)76-6)16-21-41(33)57(73)69-32-47(65-55(71)35(3)63-5)59(75)67(49-13-9-11-15-51(49)69)30-45-43-23-20-40(61)28-37(43)18-25-53(45)77-7/h8-28,34-35,46-47,62-63H,29-32H2,1-7H3,(H,64,70)(H,65,71)/t34-,35-,46-,47-/m0/s1 PJTRCKWNFSSWCE-CLBURSBNSA-N 240901 US9409888, 10 E3 ubiquitin-protein ligase XIAP [124-240] 1.375 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240901 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240901&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76283534 341093223 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420375 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2cc(C)c(cc2C)C(=O)N2C[C@H](NC(=O)[C@H](C)N)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C59H58Br2N8O8/c1-32-25-43(57(73)69-31-47(65-55(71)35(4)63-5)59(75)67(49-13-9-11-15-51(49)69)29-45-41-21-19-39(61)27-37(41)17-23-53(45)77-7)33(2)24-42(32)56(72)68-30-46(64-54(70)34(3)62)58(74)66(48-12-8-10-14-50(48)68)28-44-40-20-18-38(60)26-36(40)16-22-52(44)76-6/h8-27,34-35,46-47,63H,28-31,62H2,1-7H3,(H,64,70)(H,65,71)/t34-,35-,46-,47-/m0/s1 WHHWXTAPRGBQGN-CLBURSBNSA-N 240902 US9409888, 13 E3 ubiquitin-protein ligase XIAP [124-240] 0.801 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240902 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240902&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90221060 341093224 C03803 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420376 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2cccc(c2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C58H56Br2N8O8/c1-33(61-3)53(69)63-45-31-67(49-16-9-7-14-47(49)65(57(45)73)29-43-41-22-20-39(59)27-35(41)18-24-51(43)75-5)55(71)37-12-11-13-38(26-37)56(72)68-32-46(64-54(70)34(2)62-4)58(74)66(48-15-8-10-17-50(48)68)30-44-42-23-21-40(60)28-36(42)19-25-52(44)76-6/h7-28,33-34,45-46,61-62H,29-32H2,1-6H3,(H,63,69)(H,64,70)/t33-,34-,45-,46-/m0/s1 PQGPVQQEGIDVFM-MLLHAFNLSA-N 240903 US9409888, 6 E3 ubiquitin-protein ligase XIAP [124-240] 0.8995 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240903 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240903&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76281539 341093225 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420377 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2cncc(c2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccccc23)c2ccccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O InChI=1S/C57H55Br2N9O8/c1-32(60-3)52(69)63-44-30-67(48-13-9-7-11-46(48)65(56(44)73)28-42-40-19-17-38(58)24-34(40)15-21-50(42)75-5)54(71)36-23-37(27-62-26-36)55(72)68-31-45(64-53(70)33(2)61-4)57(74)66(47-12-8-10-14-49(47)68)29-43-41-20-18-39(59)25-35(41)16-22-51(43)76-6/h7-27,32-33,44-45,60-61H,28-31H2,1-6H3,(H,63,69)(H,64,70)/t32-,33-,44-,45-/m0/s1 QFQACUKMMOURCC-GQZZGPPCSA-N 240904 US9409888, 8 E3 ubiquitin-protein ligase XIAP [124-240] 1.325 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240904 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240904&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 76283292 341093226 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 420378 CN[C@@H](C)C(=O)N[C@H]1CN(C(=O)c2ccc(cc2)C(=O)N2C[C@H](NC(=O)[C@H](C)NC)C(=O)N(Cc3c(OC)ccc4cc(Br)ccc34)c3ccc(cc23)C#N)c2cc(ccc2N(Cc2c(OC)ccc3cc(Br)ccc23)C1=O)C#N InChI=1S/C60H54Br2N10O8/c1-33(65-3)55(73)67-47-31-71(51-23-35(27-63)7-19-49(51)69(59(47)77)29-45-43-17-15-41(61)25-39(43)13-21-53(45)79-5)57(75)37-9-11-38(12-10-37)58(76)72-32-48(68-56(74)34(2)66-4)60(78)70(50-20-8-36(28-64)24-52(50)72)30-46-44-18-16-42(62)26-40(44)14-22-54(46)80-6/h7-26,33-34,47-48,65-66H,29-32H2,1-6H3,(H,67,73)(H,68,74)/t33-,34-,47-,48-/m0/s1 HTOSWKJYDYFOEH-KUFAWANDSA-N 240905 US9409888, 27 E3 ubiquitin-protein ligase XIAP [124-240] 1.165 7.5 25.00 C US Patent 10.7270/Q2R78D4N aid1803266 US9409888 Mischke, SG Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=240905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=240905&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90231685 341093227 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416937 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@H](C(=O)Nc2c(F)cccc2F)C(C)(C)c2ccccc12 InChI=1S/C26H32F2N4O3/c1-14(2)20(30-23(33)15(3)29-6)25(35)32-19-13-8-7-10-16(19)26(4,5)22(32)24(34)31-21-17(27)11-9-12-18(21)28/h7-15,20,22,29H,1-6H3,(H,30,33)(H,31,34)/t15-,20-,22+/m0/s1 JVKFCLCUILQTAK-GJULWVSJSA-N 238829 US9403768, 1 E3 ubiquitin-protein ligase XIAP [124-240] 21.2 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238829&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73442923 340132167 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416938 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc12)C(N)=O InChI=1S/C18H26N4O3/c1-10(2)15(21-17(24)11(3)20-4)18(25)22-13-8-6-5-7-12(13)9-14(22)16(19)23/h5-8,10-11,14-15,20H,9H2,1-4H3,(H2,19,23)(H,21,24)/t11-,14-,15-/m0/s1 DQGJEZPERGYKQV-CQDKDKBSSA-N 238830 US9403768, 2 E3 ubiquitin-protein ligase XIAP [124-240] 2179 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238830&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117871469 340132168 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416939 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc12)C(=O)NCc1ccccc1 InChI=1S/C25H32N4O3/c1-16(2)22(28-23(30)17(3)26-4)25(32)29-20-13-9-8-12-19(20)14-21(29)24(31)27-15-18-10-6-5-7-11-18/h5-13,16-17,21-22,26H,14-15H2,1-4H3,(H,27,31)(H,28,30)/t17-,21-,22-/m0/s1 BRAIPJPEKYOWOF-HSQYWUDLSA-N 238831 US9403768, 3 E3 ubiquitin-protein ligase XIAP [124-240] 11186.67 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238831&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117870989 340132169 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416940 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc12)C(=O)NCc1cc(F)ccc1C InChI=1S/C26H33FN4O3/c1-15(2)23(30-24(32)17(4)28-5)26(34)31-21-9-7-6-8-18(21)13-22(31)25(33)29-14-19-12-20(27)11-10-16(19)3/h6-12,15,17,22-23,28H,13-14H2,1-5H3,(H,29,33)(H,30,32)/t17-,22-,23-/m0/s1 BUAAXJYLVOUDGL-RTFZILSDSA-N 238832 US9403768, 4 E3 ubiquitin-protein ligase XIAP [124-240] 883.5 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238832&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117872371 340132170 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416941 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc12)C(=O)Nc1ccccc1C(=O)c1ccccc1 InChI=1S/C31H34N4O4/c1-19(2)27(34-29(37)20(3)32-4)31(39)35-25-17-11-8-14-22(25)18-26(35)30(38)33-24-16-10-9-15-23(24)28(36)21-12-6-5-7-13-21/h5-17,19-20,26-27,32H,18H2,1-4H3,(H,33,38)(H,34,37)/t20-,26-,27-/m0/s1 MQXBWRKEJIVKQK-RZDWPUGNSA-N 238833 US9403768, 5 E3 ubiquitin-protein ligase XIAP [124-240] 1483.5 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238833&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117886634 340132171 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416942 CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)NCc1cc(F)ccc1C)c1ccccc1 InChI=1S/C29H31FN4O3/c1-18-13-14-23(30)15-22(18)17-32-28(36)25-16-21-11-7-8-12-24(21)34(25)29(37)26(20-9-5-4-6-10-20)33-27(35)19(2)31-3/h4-15,19,25-26,31H,16-17H2,1-3H3,(H,32,36)(H,33,35)/t19-,25-,26-/m0/s1 GQUQVPSQPADHBH-CNVLFFCLSA-N 238834 US9403768, 6 E3 ubiquitin-protein ligase XIAP [124-240] 190 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238834&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117871180 340132172 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416943 CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(N)=O)c1ccccc1 InChI=1S/C21H24N4O3/c1-13(23-2)20(27)24-18(14-8-4-3-5-9-14)21(28)25-16-11-7-6-10-15(16)12-17(25)19(22)26/h3-11,13,17-18,23H,12H2,1-2H3,(H2,22,26)(H,24,27)/t13-,17-,18-/m0/s1 KKAYVCMQRFGAAY-KKXDTOCCSA-N 238835 US9403768, 7 E3 ubiquitin-protein ligase XIAP [124-240] 368 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238835&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117870970 340132173 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416944 CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)Nc1ccccc1)c1ccccc1 InChI=1S/C27H28N4O3/c1-18(28-2)25(32)30-24(19-11-5-3-6-12-19)27(34)31-22-16-10-9-13-20(22)17-23(31)26(33)29-21-14-7-4-8-15-21/h3-16,18,23-24,28H,17H2,1-2H3,(H,29,33)(H,30,32)/t18-,23-,24-/m0/s1 SXGUMECDXUJBHY-NWVWQQAFSA-N 238836 US9403768, 8 E3 ubiquitin-protein ligase XIAP [124-240] 226 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238836&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117872174 340132174 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416945 CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)Nc1ccccc1-c1ccccc1)c1ccccc1 InChI=1S/C33H32N4O3/c1-22(34-2)31(38)36-30(24-15-7-4-8-16-24)33(40)37-28-20-12-9-17-25(28)21-29(37)32(39)35-27-19-11-10-18-26(27)23-13-5-3-6-14-23/h3-20,22,29-30,34H,21H2,1-2H3,(H,35,39)(H,36,38)/t22-,29-,30-/m0/s1 CZIYTJPCQLULDO-AXRGIPJOSA-N 238837 US9403768, 9 E3 ubiquitin-protein ligase XIAP [124-240] 135 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238837&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117872952 340132175 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416946 CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)Nc1ccccc1OC)c1ccccc1 InChI=1S/C28H30N4O4/c1-18(29-2)26(33)31-25(19-11-5-4-6-12-19)28(35)32-22-15-9-7-13-20(22)17-23(32)27(34)30-21-14-8-10-16-24(21)36-3/h4-16,18,23,25,29H,17H2,1-3H3,(H,30,34)(H,31,33)/t18-,23-,25-/m0/s1 JUXJGXGRLAAUNQ-WYRQLCSISA-N 238838 US9403768, 10 E3 ubiquitin-protein ligase XIAP [124-240] 174 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238838&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117886657 340132176 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416947 CN[C@@H](C)C(=O)N[C@H](C(=O)N1[C@@H](Cc2ccccc12)C(=O)NCc1ccccc1)c1ccccc1 InChI=1S/C28H30N4O3/c1-19(29-2)26(33)31-25(21-13-7-4-8-14-21)28(35)32-23-16-10-9-15-22(23)17-24(32)27(34)30-18-20-11-5-3-6-12-20/h3-16,19,24-25,29H,17-18H2,1-2H3,(H,30,34)(H,31,33)/t19-,24-,25-/m0/s1 CQOHSROJVMHERP-LQGLAIQGSA-N 238839 US9403768, 11 E3 ubiquitin-protein ligase XIAP [124-240] 723 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238839&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117886658 340132177 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 416948 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](Cc2ccccc12)C(=O)Nc1c(F)cccc1F InChI=1S/C24H28F2N4O3/c1-13(2)20(28-22(31)14(3)27-4)24(33)30-18-11-6-5-8-15(18)12-19(30)23(32)29-21-16(25)9-7-10-17(21)26/h5-11,13-14,19-20,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,20-/m0/s1 MIGUACSHWHEKTK-GKCIPKSASA-N 238840 US9403768, 12 E3 ubiquitin-protein ligase XIAP [124-240] 53 7.5 37.00 C US Patent 10.7270/Q2BC3XG3 aid1803190 US9403768 Hogg, JH; Remiszewski, S; Yun, W Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=238840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=238840&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 117887617 340132178 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423600 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C24H28F2N4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21-/m0/s1 YNOFZLZJYPZEQY-JBYOLUDKSA-N 242826 US9422332, 1 E3 ubiquitin-protein ligase XIAP [124-240] 12 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242826 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242826&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296814 341094965 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423601 CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C27H32F2N4O3/c1-16(30-2)25(34)31-22(17-9-4-3-5-10-17)27(36)33-15-18-11-6-7-12-19(18)24(33)26(35)32-23-20(28)13-8-14-21(23)29/h6-8,11-14,16-17,22,24,30H,3-5,9-10,15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1 DDWIMXPIGZMOPL-DQLWACAZSA-N 242827 US9422332, 2 E3 ubiquitin-protein ligase XIAP [124-240] 9 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242827&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295232 341094966 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423602 CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C28H34F2N4O3/c1-17(31-2)26(35)32-23(19-10-4-3-5-11-19)28(37)34-16-15-18-9-6-7-12-20(18)25(34)27(36)33-24-21(29)13-8-14-22(24)30/h6-9,12-14,17,19,23,25,31H,3-5,10-11,15-16H2,1-2H3,(H,32,35)(H,33,36)/t17-,23-,25-/m0/s1 OGFVMPVCWFREMI-XPEQFSOGSA-N 242828 US9422332, 3 E3 ubiquitin-protein ligase XIAP [124-240] 26 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242828&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295402 341094967 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423603 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1Cl InChI=1S/C25H30ClFN4O3/c1-14(2)20(29-23(32)15(3)28-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1 HDSUEMVVBHXAFF-LVWPNOBMSA-N 242829 US9422332, 4 E3 ubiquitin-protein ligase XIAP [124-240] 6 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242829&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73294891 341094968 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423604 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(Cl)ccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1 GAFFUNZAQFRLEV-FSJXIACGSA-N 242830 US9422332, 5 E3 ubiquitin-protein ligase XIAP [124-240] 21 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242830&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070321 341094969 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423605 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(F)ccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1 BWSRUACPTLNELP-FSJXIACGSA-N 242831 US9422332, 6 E3 ubiquitin-protein ligase XIAP [124-240] 25 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242831&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070333 341094970 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423606 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(Cl)cccc1Cl InChI=1S/C24H28Cl2N4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21-/m0/s1 UXSNKCGXQFHARH-JBYOLUDKSA-N 242832 US9422332, 7 E3 ubiquitin-protein ligase XIAP [124-240] 9 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242832&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296816 341094971 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423607 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1Cl InChI=1S/C24H28ClFN4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21-/m0/s1 ZBEWQVCPZWVINP-JBYOLUDKSA-N 242833 US9422332, 8 E3 ubiquitin-protein ligase XIAP [124-240] 10 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242833&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296818 341094972 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423608 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2sccc12 InChI=1S/C26H30N4O3S/c1-15(2)22(29-24(31)16(3)27-4)26(33)30-14-17-8-5-6-9-18(17)23(30)25(32)28-20-10-7-11-21-19(20)12-13-34-21/h5-13,15-16,22-23,27H,14H2,1-4H3,(H,28,32)(H,29,31)/t16-,22-,23-/m0/s1 RSDRESUMVABCOP-GMWOSMDTSA-N 242834 US9422332, 9 E3 ubiquitin-protein ligase XIAP [124-240] 43 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242834&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296820 341094973 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423609 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H30F2N4O3/c1-5-14(2)20(29-23(32)15(3)28-4)25(34)31-13-16-9-6-7-10-17(16)22(31)24(33)30-21-18(26)11-8-12-19(21)27/h6-12,14-15,20,22,28H,5,13H2,1-4H3,(H,29,32)(H,30,33)/t14-,15-,20-,22-/m0/s1 LCTFKLDICVAVFH-AAOZFHDLSA-N 242850 US9422332, 10 E3 ubiquitin-protein ligase XIAP [124-240] 6 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242850&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296822 341094989 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423610 CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C InChI=1S/C25H30F2N4O3/c1-14(28-5)22(32)30-21(25(2,3)4)24(34)31-13-15-9-6-7-10-16(15)20(31)23(33)29-19-17(26)11-8-12-18(19)27/h6-12,14,20-21,28H,13H2,1-5H3,(H,29,33)(H,30,32)/t14-,20-,21+/m0/s1 YVSLGVHZPIUKJU-SZFUDVHCSA-N 242851 US9422332, 11 E3 ubiquitin-protein ligase XIAP [124-240] 13 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242851&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296970 341094990 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423611 CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C26H30F2N4O4/c1-15(29-2)24(33)30-21(16-10-12-36-13-11-16)26(35)32-14-17-6-3-4-7-18(17)23(32)25(34)31-22-19(27)8-5-9-20(22)28/h3-9,15-16,21,23,29H,10-14H2,1-2H3,(H,30,33)(H,31,34)/t15-,21-,23-/m0/s1 SNFXXGKTSGDKDJ-GNOCETLISA-N 242852 US9422332, 12 E3 ubiquitin-protein ligase XIAP [124-240] 14 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242852&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295406 341094991 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423612 CN[C@@H](C)C(=O)N[C@@H](C1CCCC1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C26H30F2N4O3/c1-15(29-2)24(33)30-21(16-8-3-4-9-16)26(35)32-14-17-10-5-6-11-18(17)23(32)25(34)31-22-19(27)12-7-13-20(22)28/h5-7,10-13,15-16,21,23,29H,3-4,8-9,14H2,1-2H3,(H,30,33)(H,31,34)/t15-,21-,23-/m0/s1 CVWDCEZKVJVZSZ-GNOCETLISA-N 242853 US9422332, 13 E3 ubiquitin-protein ligase XIAP [124-240] 23 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242853&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295234 341094992 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423613 CN[C@@H](C)C(=O)N[C@@H](C1CCOCC1)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C27H32F2N4O4/c1-16(30-2)25(34)31-22(18-11-14-37-15-12-18)27(36)33-13-10-17-6-3-4-7-19(17)24(33)26(35)32-23-20(28)8-5-9-21(23)29/h3-9,16,18,22,24,30H,10-15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1 ZJGSFXWNPAPPLS-DQLWACAZSA-N 242859 US9422332, 14 E3 ubiquitin-protein ligase XIAP [124-240] 16 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242859&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295408 341094998 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423614 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C26H32F2N4O3/c1-5-15(2)21(30-24(33)16(3)29-4)26(35)32-14-13-17-9-6-7-10-18(17)23(32)25(34)31-22-19(27)11-8-12-20(22)28/h6-12,15-16,21,23,29H,5,13-14H2,1-4H3,(H,30,33)(H,31,34)/t15-,16-,21-,23-/m0/s1 KSBNQYOCBLBSQW-BAHGIXHPSA-N 242860 US9422332, 15 E3 ubiquitin-protein ligase XIAP [124-240] 13 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242860&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295053 341094999 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423615 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)Nc1ccccc1 InChI=1S/C24H30N4O3/c1-15(2)20(27-22(29)16(3)25-4)24(31)28-14-17-10-8-9-13-19(17)21(28)23(30)26-18-11-6-5-7-12-18/h5-13,15-16,20-21,25H,14H2,1-4H3,(H,26,30)(H,27,29)/t16-,20-,21?/m0/s1 WHPNYQNVPSVJRI-SQWITBJMSA-N 242845 US9422332, 16 E3 ubiquitin-protein ligase XIAP [124-240] 233 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242845&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296972 341094984 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423616 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)Nc1ccccc1OC InChI=1S/C25H32N4O4/c1-15(2)21(28-23(30)16(3)26-4)25(32)29-14-17-10-6-7-11-18(17)22(29)24(31)27-19-12-8-9-13-20(19)33-5/h6-13,15-16,21-22,26H,14H2,1-5H3,(H,27,31)(H,28,30)/t16-,21-,22?/m0/s1 WQEZIDJTMZKOID-HYAAYGGESA-N 242846 US9422332, 17 E3 ubiquitin-protein ligase XIAP [124-240] 177 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242846&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296974 341094985 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423617 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C24H28F2N4O3/c1-13(2)19(28-22(31)14(3)27-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t14-,19-,21+/m0/s1 YNOFZLZJYPZEQY-ONTRVFCTSA-N 242835 US9422332, 18 E3 ubiquitin-protein ligase XIAP [124-240] 139 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242835&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070352 341094974 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423618 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)NCc1ccccc1 InChI=1S/C25H32N4O3/c1-16(2)21(28-23(30)17(3)26-4)25(32)29-15-19-12-8-9-13-20(19)22(29)24(31)27-14-18-10-6-5-7-11-18/h5-13,16-17,21-22,26H,14-15H2,1-4H3,(H,27,31)(H,28,30)/t17-,21-,22?/m0/s1 DWYXOSQSORZHMJ-MNDAUZPPSA-N 242847 US9422332, 19 E3 ubiquitin-protein ligase XIAP [124-240] 210 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242847&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296976 341094986 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423619 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)NCCc1ccccc1 InChI=1S/C26H34N4O3/c1-17(2)22(29-24(31)18(3)27-4)26(33)30-16-20-12-8-9-13-21(20)23(30)25(32)28-15-14-19-10-6-5-7-11-19/h5-13,17-18,22-23,27H,14-16H2,1-4H3,(H,28,32)(H,29,31)/t18-,22-,23?/m0/s1 SQPRJACUIDCUAT-OFSKKJKASA-N 242848 US9422332, 20 E3 ubiquitin-protein ligase XIAP [124-240] 810 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242848&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73296978 341094987 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423620 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2ccccc12 InChI=1S/C28H32N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-20-11-6-8-14-22(20)25(32)27(34)30-23-15-9-12-19-10-5-7-13-21(19)23/h5-15,17-18,24-25,29H,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25-/m0/s1 OIIRWWPXPNYPLG-WDNCENIBSA-N 242836 US9422332, 21 E3 ubiquitin-protein ligase XIAP [124-240] 5 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242836&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 72943566 341094975 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423621 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@@H]1C(=O)Nc1cccc2ccccc12 InChI=1S/C28H32N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-20-11-6-8-14-22(20)25(32)27(34)30-23-15-9-12-19-10-5-7-13-21(19)23/h5-15,17-18,24-25,29H,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25+/m0/s1 OIIRWWPXPNYPLG-RIEVBORMSA-N 242837 US9422332, 22 E3 ubiquitin-protein ligase XIAP [124-240] 2794 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242837&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73297144 341094976 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423622 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1ccc2ccccc2c1 InChI=1S/C28H32N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-21-11-7-8-12-23(21)25(32)27(34)30-22-14-13-19-9-5-6-10-20(19)15-22/h5-15,17-18,24-25,29H,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25-/m0/s1 OVLLGRFMIOPPBS-WDNCENIBSA-N 242838 US9422332, 23 E3 ubiquitin-protein ligase XIAP [124-240] 117 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242838&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73297146 341094977 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423623 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1ccccc1F InChI=1S/C24H29FN4O3/c1-14(2)20(28-22(30)15(3)26-4)24(32)29-13-16-9-5-6-10-17(16)21(29)23(31)27-19-12-8-7-11-18(19)25/h5-12,14-15,20-21,26H,13H2,1-4H3,(H,27,31)(H,28,30)/t15-,20-,21-/m0/s1 AGSUIXQXNBZLKY-JHVJFLLYSA-N 242839 US9422332, 24 E3 ubiquitin-protein ligase XIAP [124-240] 22 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242839&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73297148 341094978 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423624 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H30F2N4O3/c1-14(2)20(29-23(32)15(3)28-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1 PZXNEDCIDKOIEV-LVWPNOBMSA-N 242861 US9422332, 25 E3 ubiquitin-protein ligase XIAP [124-240] 27 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242861&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295055 341095000 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423625 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1ccccc1Cl InChI=1S/C24H29ClN4O3/c1-14(2)20(28-22(30)15(3)26-4)24(32)29-13-16-9-5-6-10-17(16)21(29)23(31)27-19-12-8-7-11-18(19)25/h5-12,14-15,20-21,26H,13H2,1-4H3,(H,27,31)(H,28,30)/t15-,20-,21-/m0/s1 GRROBYAGJCKXGO-JHVJFLLYSA-N 242840 US9422332, 26 E3 ubiquitin-protein ligase XIAP [124-240] 21 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242840&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73297150 341094979 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423626 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2CCCCc12 InChI=1S/C28H36N4O3/c1-17(2)24(31-26(33)18(3)29-4)28(35)32-16-20-11-6-8-14-22(20)25(32)27(34)30-23-15-9-12-19-10-5-7-13-21(19)23/h6,8-9,11-12,14-15,17-18,24-25,29H,5,7,10,13,16H2,1-4H3,(H,30,34)(H,31,33)/t18-,24-,25-/m0/s1 NMRBTFZYRNGDEW-WDNCENIBSA-N 242841 US9422332, 27 E3 ubiquitin-protein ligase XIAP [124-240] 106 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242841&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73294743 341094980 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423627 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2cccnc12 InChI=1S/C27H31N5O3/c1-16(2)22(31-25(33)17(3)28-4)27(35)32-15-19-9-5-6-12-20(19)24(32)26(34)30-21-13-7-10-18-11-8-14-29-23(18)21/h5-14,16-17,22,24,28H,15H2,1-4H3,(H,30,34)(H,31,33)/t17-,22-,24-/m0/s1 FIYCTXVMDAYJKR-OWSXEPHWSA-N 242842 US9422332, 28 E3 ubiquitin-protein ligase XIAP [124-240] 6589 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242842&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73297152 341094981 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423628 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C1C(=O)Nc1nccc2ccccc12 InChI=1S/C27H31N5O3/c1-16(2)22(30-25(33)17(3)28-4)27(35)32-15-19-10-6-7-11-20(19)23(32)26(34)31-24-21-12-8-5-9-18(21)13-14-29-24/h5-14,16-17,22-23,28H,15H2,1-4H3,(H,30,33)(H,29,31,34)/t17-,22-,23?/m0/s1 KPUZPIFZJIWBBD-QPTFRZOZSA-N 242849 US9422332, 29 E3 ubiquitin-protein ligase XIAP [124-240] 345 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242849&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73294724 341094988 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423629 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1cccc2n(C)ccc12 InChI=1S/C27H33N5O3/c1-16(2)23(30-25(33)17(3)28-4)27(35)32-15-18-9-6-7-10-19(18)24(32)26(34)29-21-11-8-12-22-20(21)13-14-31(22)5/h6-14,16-17,23-24,28H,15H2,1-5H3,(H,29,34)(H,30,33)/t17-,23-,24-/m0/s1 UPXIKBFAEMLHBX-DPSWKAHMSA-N 242843 US9422332, 30 E3 ubiquitin-protein ligase XIAP [124-240] 40 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242843&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73294726 341094982 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423630 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H30F2N4O3/c1-14(2)21(29-23(32)15(3)28-4)25(34)31-13-17-9-6-5-8-16(17)12-20(31)24(33)30-22-18(26)10-7-11-19(22)27/h5-11,14-15,20-21,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,21-/m0/s1 ARPGUODPOBQTIF-JHVJFLLYSA-N 242872 US9422332, 31 E3 ubiquitin-protein ligase XIAP [124-240] 37 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242872&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295229 341095011 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423631 CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)OC)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C24H28F2N4O4/c1-13(27-3)22(31)28-19(14(2)34-4)24(33)30-12-15-8-5-6-9-16(15)21(30)23(32)29-20-17(25)10-7-11-18(20)26/h5-11,13-14,19,21,27H,12H2,1-4H3,(H,28,31)(H,29,32)/t13-,14+,19-,21-/m0/s1 SMBHIHDNUDHLPT-AAJFEFCHSA-N 242854 US9422332, 32 E3 ubiquitin-protein ligase XIAP [124-240] 24 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242854&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070334 341094993 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423632 CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C23H26F2N4O4/c1-12(26-3)21(31)27-18(13(2)30)23(33)29-11-14-7-4-5-8-15(14)20(29)22(32)28-19-16(24)9-6-10-17(19)25/h4-10,12-13,18,20,26,30H,11H2,1-3H3,(H,27,31)(H,28,32)/t12-,13+,18-,20-/m0/s1 BMBPIAUFAXALLP-QLBVAGGCSA-N 242855 US9422332, 33 E3 ubiquitin-protein ligase XIAP [124-240] 16 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242855&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73294730 341094994 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423633 CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)c1ccccc1 InChI=1S/C27H26F2N4O3/c1-16(30-2)25(34)31-22(17-9-4-3-5-10-17)27(36)33-15-18-11-6-7-12-19(18)24(33)26(35)32-23-20(28)13-8-14-21(23)29/h3-14,16,22,24,30H,15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1 HZMOZYKHYCWNAX-DQLWACAZSA-N 242856 US9422332, 34 E3 ubiquitin-protein ligase XIAP [124-240] 32 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242856&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90041005 341094995 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423634 CN[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H30F2N4O3/c1-14(2)12-20(29-23(32)15(3)28-4)25(34)31-13-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1 OHOQSMXCQQKXFR-LVWPNOBMSA-N 242857 US9422332, 35 E3 ubiquitin-protein ligase XIAP [124-240] 27 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242857&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73294732 341094996 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423635 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(Cl)cccc1Cl InChI=1S/C25H30Cl2N4O3/c1-14(2)20(29-23(32)15(3)28-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t15-,20-,22-/m0/s1 ZKKNQUVNTNADDY-LVWPNOBMSA-N 242865 US9422332, 36 E3 ubiquitin-protein ligase XIAP [124-240] 25 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242865&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295057 341095004 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423636 CN[C@@H](C)C(=O)N[C@@H](C1CCCC1)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C27H32F2N4O3/c1-16(30-2)25(34)31-22(18-9-3-4-10-18)27(36)33-15-14-17-8-5-6-11-19(17)24(33)26(35)32-23-20(28)12-7-13-21(23)29/h5-8,11-13,16,18,22,24,30H,3-4,9-10,14-15H2,1-2H3,(H,31,34)(H,32,35)/t16-,22-,24-/m0/s1 BRPHOGJVARBKFY-DQLWACAZSA-N 242862 US9422332, 37 E3 ubiquitin-protein ligase XIAP [124-240] 34 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242862&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295404 341095001 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423637 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F)C(C)(C)C InChI=1S/C26H32F2N4O3/c1-15(29-5)23(33)31-22(26(2,3)4)25(35)32-14-13-16-9-6-7-10-17(16)21(32)24(34)30-20-18(27)11-8-12-19(20)28/h6-12,15,21-22,29H,13-14H2,1-5H3,(H,30,34)(H,31,33)/t15-,21-,22+/m0/s1 CQIGUCGAGPNYFD-UZQPLGKSSA-N 242863 US9422332, 38 E3 ubiquitin-protein ligase XIAP [124-240] 62 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242863&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295060 341095002 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423638 CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)OC)C(=O)N1CCc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H30F2N4O4/c1-14(28-3)23(32)29-20(15(2)35-4)25(34)31-13-12-16-8-5-6-9-17(16)22(31)24(33)30-21-18(26)10-7-11-19(21)27/h5-11,14-15,20,22,28H,12-13H2,1-4H3,(H,29,32)(H,30,33)/t14-,15+,20-,22-/m0/s1 QGADRPOVIYDVNE-AUKWGBGVSA-N 242864 US9422332, 39 E3 ubiquitin-protein ligase XIAP [124-240] 93 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242864&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73295228 341095003 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423639 CN[C@@H](C)C(=O)N[C@@H]([C@@H](C)c1ccccc1)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C29H30F2N4O3/c1-17(19-10-5-4-6-11-19)24(33-27(36)18(2)32-3)29(38)35-16-20-12-7-8-13-21(20)26(35)28(37)34-25-22(30)14-9-15-23(25)31/h4-15,17-18,24,26,32H,16H2,1-3H3,(H,33,36)(H,34,37)/t17-,18-,24-,26-/m0/s1 WBUURMCHXPBGHE-VHCMOQRASA-N 242858 US9422332, 40 E3 ubiquitin-protein ligase XIAP [124-240] 117 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242858&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73294887 341094997 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423640 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(F)cc2[C@@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1 RRQHSAJDWNSTCR-PRPYNDMISA-N 242869 US9422332, 41 E3 ubiquitin-protein ligase XIAP [124-240] 2353 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242869&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070335 341095008 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423641 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(F)cc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1 RRQHSAJDWNSTCR-FSJXIACGSA-N 242870 US9422332, 42 E3 ubiquitin-protein ligase XIAP [124-240] 27 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242870&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070337 341095009 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423642 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(F)ccc2[C@@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H29F3N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1 BWSRUACPTLNELP-PRPYNDMISA-N 242871 US9422332, 43 E3 ubiquitin-protein ligase XIAP [124-240] 3483 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242871&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070354 341095010 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423643 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(Cl)cc2[C@@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1 WGBUPYUICPSVDW-PRPYNDMISA-N 242866 US9422332, 44 E3 ubiquitin-protein ligase XIAP [124-240] 4706 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242866&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070358 341095005 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423644 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2ccc(Cl)cc2[C@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-8-9-16(26)12-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22-/m0/s1 WGBUPYUICPSVDW-FSJXIACGSA-N 242867 US9422332, 45 E3 ubiquitin-protein ligase XIAP [124-240] 47 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242867&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070353 341095006 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423645 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCc2cc(Cl)ccc2[C@@H]1C(=O)Nc1c(F)cccc1F InChI=1S/C25H29ClF2N4O3/c1-13(2)20(30-23(33)14(3)29-4)25(35)32-11-10-15-12-16(26)8-9-17(15)22(32)24(34)31-21-18(27)6-5-7-19(21)28/h5-9,12-14,20,22,29H,10-11H2,1-4H3,(H,30,33)(H,31,34)/t14-,20-,22+/m0/s1 GAFFUNZAQFRLEV-PRPYNDMISA-N 242868 US9422332, 46 E3 ubiquitin-protein ligase XIAP [124-240] 3995 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242868&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 90070355 341095007 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 423646 CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1Cc2ccccc2[C@H]1C(=O)Nc1c(C)cccc1F InChI=1S/C25H31FN4O3/c1-14(2)20(28-23(31)16(4)27-5)25(33)30-13-17-10-6-7-11-18(17)22(30)24(32)29-21-15(3)9-8-12-19(21)26/h6-12,14,16,20,22,27H,13H2,1-5H3,(H,28,31)(H,29,32)/t16-,20-,22-/m0/s1 DSXLSZKLOAGXRS-BUKVSMQUSA-N 242844 US9422332, 47 E3 ubiquitin-protein ligase XIAP [124-240] 19 7.5 37.00 C US Patent 10.7270/Q23F4NJK aid1803318 US9422332 Hogg, JH; Le, K; Lou, Y; Mischke, SG; Remiszewski, S Hoffmann-La Roche Inc http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=242844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10395&target=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=242844&enzyme=E3+ubiquitin-protein+ligase+XIAP+%5B124-240%5D&column=ki&startPg=0&Increment=50&submit=Search 73294889 341094983 1 RDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFACGGKLKNWEPGDRAWSEHRRHFPNCFFVLGRNLNIRSE 1C9Q,1I3O,4J3Y,4J44,4J45,4J46,4J47,4J48,4KJU,4KJV E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14